Search

The properties of the interface between Si(111) and 3C-SiC(111) grown by the method of coordinated substitution of atoms were studied by the density functional theory in spin-polarized approximation. The most favourable atomic configuration at the interface was found. It is shown that SiC faces Si with the carbon plane, and SiC separates 3 Si atoms out of 16 from the second layer of substrate atoms. As a result, the 3 Si atoms in the substrate each have 3 bonds instead of 4, and the 3 C atoms in the bottom layer of the SiC film also have 3 bonds. It is these atoms that have a magnetic moment due to the unpaired p-electrons. It was found that for the electron with spin "majority" this interface is an ordinary semiconductor, and for the electron with spin "minority" it is a two-dimensional ferromagnetic metal. Keywords: silicon carbide, ferromagnetic semi-metals, terahertz radiation, density functional theory, spintronics.

20th International Seminar on High Energy Physics, Quarks 2018, Valday, Russian Federation, 27 May 2018 - 2 Jun 2018; Physics of atomic nuclei 191(3), 362 - 367 (2018). doi:10.1134/S1063778821030078, The physics motivations and advantages of the hybrid detector complex TAIGA are presented. TAIGA aims to address gamma-ray astronomy at energies from a few TeV to several PeV units, as well as cosmic-ray physics from 100 TeV to several EeV units and astroparticle physics problems. In 2021 deployment and commissioning of the one square kilometer TAIGA setup in the Tunka valley $\sim$50 km West from Lake Baikal will be finished. The first experimental results with the TAIGA are presented., Published by AIP, New York, NY

The corrected dependence of the mean depth of the EAS maximum $X_{max}$ on the energy was obtained from the data of the Tunka-133 array for 7 years and the TAIGA-HiSCORE array for 2 years. The parameter $\langle\ln A\rangle$, characterizing the mean mass compositon was derived from these results. The differential energy spectrum of primary cosmic rays in the energy range of $2\cdot 10^{14}$ - $2\cdot 10^{16}$\,eV was reconstructed using the new parameter $Q_{100}$ the Cherenkov light flux at the core distance 100 m.}, Comment: 6 pages, 3 figures, Submitted to SciPost Phys.Proc

5th International Conference on Technology and Instrumentation in Particle Physics, TIPP 2021, Online, United States, 24 May 2021 - 28 May 2021; Journal of physics / Conference Series 2374(1), 012042 (2022). doi:10.1088/1742-6596/2374/1/012042, The TAIGA gamma observatory is continuing its deployment at the Tunka valley, close to lake Baikal. The new, original detectors, able to work under severe conditions of Siberia, were developed to increase the TAIGA sensitivity for the study of gamma-quanta at energies about 1 PeV and above. The distinguishing feature of the detectors is the use of the wavelength shifting light guides for scintillation light collection on a photodetector. Several designs of the counters have been tested: equipped with PMT or SiPM photo-detectors, acrylic or polystyrene based scintillators with thickness from 1 to 5 cm and detecting area from 0.75 to 1.0 m$^{2}$. The data on the amplitude of the signal from cosmic muons measured in different points within the counter are presented. The first 48 counters were produced and deployed in 2019 at the TAIGA experiment. They form 3 stations each with 8 surface detectors and 8 underground detectors buried at the depth of 1.7 m. After two winters, all counters are working., Published by IOP Publ., Bristol

37th International Cosmic Ray Conference, ICRC 2021, Berlin, online, Germany, 12 Jul 2021 - 23 Jul 2021; Proceedings of Science / International School for Advanced Studies (ICRC2021), 210 (2021). doi:10.22323/1.395.0210, The recent progress in the radio detection technique for air showers paves the path to future cosmic-ray radio detectors. Digital radio arrays allow for a measurement of the air-shower energy and depth of its maximum with a resolution comparable to those of the leading optical detection methods. One of the remaining challenges regarding cosmic-ray radio instrumentation is an accurate estimation of their efficiency and aperture. We present a probabilistic model to address this challenge. We use the model to estimate the efficiency and aperture of the Tunka-Rex radio array. The basis of the model is a parametrization of the radio footprint and a probabilistic treatment of the detection process on both the antenna and array levels. In this way, we can estimate the detection efficiency for air showers as function of their arrival direction, energy, and impact point on the ground. In addition, the transparent internal relationships between the different stages of the air-shower detection process in our probabilistic approach enable to estimate the uncertainty of the efficiency and, consequently, of the aperture of radio arrays. The details of the model will be presented in the contribution., Published by SISSA, Trieste

A wide-angle Cerenkov array TAIGA-HiSCORE (FOV $\sim$0.6 sr), was originally created as a part of TAIGA installation for high-energy gamma-ray astronomy and cosmic ray physics. Array now consist on nearly 100 optical stations on the area of 1 km$^2$. Due to high accuracy and stability ($\sim$1 ns) of time synchronization of the optical stations the accuracy of EAS arrival direction reconstruction is reached 0.1$^\mathrm{o}$. It was proven that the array can also be used to search for nanosecond events of the optical range. The report discusses the method of searching for optical transients using the HiSCORE array and demonstrates its performance on a real example of detecting signals from an artificial Earth satellite. The search for this short flares in the HiSCORE data of the winter season 2018--2019 is carried out. One candidate for double repeater has been detected, but the estimated probability of random simulation of such a transient by background EAS events is not less than 10%, which does not allow us to say that the detected candidate corresponds to a real astrophysical transient. An upper bound on the frequency of optical spikes with flux density of more than $10^{-4} \mathrm{erg/s/cm}^2$ and a duration of more than 5\,ns is established as $\sim 2 \times 10^{-3}$ events/sr/hour., Comment: 15 pages, 6 figures, reported at the conference ISCRA-2021, Accepted for publication in Physics of Atomic Nuclei

X-ray diffraction and total external reflection of X-rays (X-ray reflectometry) methods were used to study the successive stages of synthesis of epitaxial SiC films on Si (100) X-ray diffraction and total external X-ray reflection (XRD) methods were used to study successive stages of synthesis of epitaxial SiC films on Si (100) surfaces, (110) and (111) surfaces by the atom substitution method. The data on the transformation evolution of (100) surfaces were studied, (110) and (111) Si, into SiC surfaces. A comparative analysis of the X-ray structural quality of the SiC layers grown on Si by the atom substitution method with the quality of SiC layers grown by Advanced Epi by the standard CVD method. A modified technique for the total outer X-ray reflection method, based on measurements of the intensity of the reflected X-rays using a special parabolic mirror. It is shown that the method of total external reflection method makes it possible to obtain important information about the degree of surface roughness of SiC layers, the evolution of their crystal structure and plasmon energy in the process of Si to SiC conversion. Keywords: total external reflection, X-ray reflectometry, silicon carbide, plasmons.

36th International Cosmic Ray Conference, ICRC2019, Madison, USA, 24 Jul 2019 - 1 Aug 2019; PoS(ICRC2019)331 (2019)., Sparse digital antenna arrays constitute a promising detection technique for future large-scale cosmic-ray observatories. It has recently been shown that this kind of instrumentation can provide a resolution of the energy and of the shower maximum on the level of other cosmic-ray detection methods. Due to the dominant geomagnetic nature of the air-shower radio emission in the traditional frequency band of 30 to 80 MHz, the amplitude and polarization of the radio signal strongly depend on the azimuth and zenith angle of the arrival direction. Thus, the estimation of the efficiency and subsequently of the aperture of an antenna array is more complex than for particle or Cherenkov-light detectors. We have built a new efficiency model based on utilizing a lateral distribution function as a shower model, and a probabilistic treatment of the detection process. The model is compared to the data measured by the Tunka Radio Extension (Tunka-Rex), a digital antenna array with an area of about 1 km$^2$ located in Siberia at the Tunka Advanced Instrument for Cosmic rays and Gamma Ray Astronomy (TAIGA). Tunka-Rex detects radio emission of air showers using trigger from air-Cherenkov and particle detectors. The present study is an essential step towards the measurement of the cosmic-ray flux with Tunka-Rex, and is important for radio measurements of air showers in general.

The Advanced LIGO and Advanced Virgo observatories recently discovered gravitational waves from a binary neutron star inspiral. A short gamma-ray burst (GRB) that followed the merger of this binary was also recorded by Fermi-GBM and INTEGRAL, indicating particle acceleration by the source. The precise location of the event was determined by optical detections of emission following the merger. We searched for high-energy neutrinos from the merger in the TeV - 100 PeV energy range using Baikal-GVD. No neutrinos directionally coincident with the source were detected within $\pm$500 s around the merger time, as well as during a 14-day period after the GW detection. We derived 90% confidence level upper limits on the neutrino fluence from GW170817 during a $\pm$500 s window centered on the GW trigger time, and a 14-day window following the GW signal under the assumption of an $E^{-2}$ neutrino energy spectrum., Comment: 4 pages, 4 figures

Baikal-GVD is a next generation, kilometer-scale neutrino telescope under construction in Lake Baikal. It is designed to detect astrophysical neutrino fluxes at energies from a few TeV up to 100 PeV. GVD is formed by multi-megaton subarrays (clusters). The array construction started in 2015 by deployment of a reduced-size demonstration cluster named "Dubna". The first cluster in its baseline configuration was deployed in 2016, the second in 2017 and the third in 2018. The full scale GVD will be an array of ~10000 light sensors with an instrumented volume of about 2 cubic km. The first phase (GVD-1) is planned to be completed by 2020-2021. It will comprise 8 clusters with 2304 light sensors in total. We describe the design of Baikal-GVD and present selected results obtained in 2015-2017., Comment: 9 pages, 8 figures. Conference proceedings for QUARKS2018

© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim In the present study, we attempted to elucidate if the harmful phytopathogenic bacteria of Pectobacterium genus (P. atrosepticum) possess the enzymes for oxidation of phenolic compounds. Polyphenol oxidase (laccase) activity was revealed in P. atrosepticum cell lysates. Using bioinformatic analysis, an ORF encoding a putative copper-containing polyphenol oxidase of 241 amino acids with a predicted molecular mass of 25.9 kDa was found. This protein (named Pal1) shares significant level of identity with laccases of a new type described for several bacterial species. Cloning and expression of the pal1 gene and the analysis of corresponding recombinant protein confirmed that Pal1 possessed laccase activity. The recombinant Pal1 protein was characterized in terms of substrate specificity, kinetic parameters, pH and temperature optimum, sensitivity to inhibitors and metal content. Pal1 demonstrated alkali- and thermo-tolerance. The kinetic parameters K m and kcat for 2,6-dimethoxyphenol were 0.353 ± 0.062 mM and 98.79 ± 4.9 s −1 , respectively. The protein displayed high tolerance to sodium azide, sodium fluoride, NaCl, SDS and cinnamic acid. The transcript level of the pal1 gene in P. atrosepticum was shown to be induced by plant-derived phenolic compound (ferulic acid) and copper sulfate.

© 2017 Gorshkov et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.The ability to adapt to adverse conditions permits many bacterial species to be virtually ubiquitous and survive in a variety of ecological niches. This ability is of particular importance for many plant pathogenic bacteria that should be able to exist, except for their host plants, in different environments e.g. soil, water, insect-vectors etc. Under some of these conditions, bacteria encounter absence of nutrients and persist, acquiring new properties related to resistance to a variety of stress factors (cross-protection). Although many studies describe the phenomenon of cross-protection and several regulatory components that induce the formation of resistant cells were elucidated, the global comparison of the physiology of cross-protected phenotype and growing cells has not been performed. In our study, we took advantage of RNA-Seq technology to gain better insights into the physiology of cross-protected cells on the example of a harmful phytopathogen, Pectobacterium atrosepticum (Pba) that causes crop losses all over the world. The success of this bacterium in plant colonization is related to both its virulence potential and ability to persist effectively under various stress conditions (including nutrient deprivation) retaining the ability to infect plants afterwards. In our previous studies, we showed Pba to be advanced in applying different adaptive strategies that led to manifestation of cell resistance to multiple stress factors. In the present study, we determined the period necessary for the formation of cross-protected Pba phenotype under starvation conditions, and compare the transcriptome profiles of non-adapted growing cells and of adapted cells after the cross-protective effect has reached the maximal level. The obtained data were verified using qRT-PCR. Genes that were expressed differentially (DEGs) in two cell types were classified into functional groups and categories using different approaches. As a result, we portrayed physiological features that distinguish cross-protected phenotype from the growing cells.

The extensive air shower Cherenkov light array Tunka-133 collected data during 7 winter seasons from 2009 to 2017. From 2175 hours of data taking, we derived the differential energy spectrum of cosmic rays in the energy range 6 · 1015 2 · 1018 eV. The TAIGA-HiSCORE array is in the process of continuous expansion and modernization. Here we present the results obtained with 28 stations of the first HiSCORE stage from 35 clear moonless nights in the winter of 2017-2018. The combined spectrum of two arrays covers a range of 2 · 1014 – 2 · 1018 eV.

A new analysis of the data from the NT200 neutrino telescope based on the reconstruction of parameters for high-energy showers generated in neutrino interactions has yielded new upper limits on the diffuse neutrino fluxes predicted by a number of theoreticalmodels. The upper limit on the all-flavor neutrino flux with an energy spectrum E −2 is E 2Φ ν < 2.9 × 10−7 GeV cm−2 s−1 sr−1.

The Tunka-Radio extension (Tunka-Rex) is a radio detector for air showers in Siberia. From 2012 to 2014, Tunka-Rex operated exclusively together with its host experiment, the air-Cherenkov array Tunka-133, which provided trigger, data acquisition, and an independent air-shower reconstruction. It was shown that the air-shower energy can be reconstructed by Tunka-Rex with a precision of 15\% for events with signal in at least 3 antennas, using the radio amplitude at a distance of 120\,m from the shower axis as an energy estimator. Using the reconstruction from the host experiment Tunka-133 for the air-shower geometry (shower core and direction), the energy estimator can in principle already be obtained with measurements from a single antenna, close to the reference distance. We present a method for event selection and energy reconstruction, requiring only one antenna, and achieving a precision of about 20\%. This method increases the effective detector area and lowers thresholds for zenith angle and energy, resulting in three times more events than in the standard reconstruction.

The Tunka Radio Extension (Tunka-Rex) is a radio detector at the TAIGA facility located in Siberia nearby the southern tip of Lake Baikal. Tunka-Rex measures air-showers induced by high-energy cosmic rays, in particular, the lateral distribution of the radio pulses. The depth of the air-shower maximum, which statistically depends on the mass of the primary particle, is determined from the slope of the lateral distribution function (LDF). Using a model-independent approach, we have studied possible features of the one-dimensional slope method and tried to find improvements for the reconstruction of primary mass. To study the systematic uncertainties given by different primary particles, we have performed simulations using the CONEX and CoREAS software packages of the recently released CORSIKA v7.5 including the modern high-energy hadronic models QGSJet-II.04 and EPOS-LHC. The simulations have shown that the largest systematic uncertainty in the energy deposit is due to the unknown primary particle. Finally, we studied the relation between the polarization and the asymmetry of the LDF., Comment: ARENA proceedings, 4 pages, updated references

© 2015 Elsevier Ltd and INQUAComplex biostratigraphical methods and radiocarbon dates were used to reconstruct the Middle (late Middle Pleistocene) and Late Neopleistocene (Late Pleistocene) palaeoenvironments covering the Palaeolithic period in the western foreland of the Urals. The Gornovo Palaeolithic settlement is located on the lowest terrace of the Belaya River. From the base to the top, this terrace consists of fluvial and lacustrine deposits of the Belaya horizon (Middle Neopleistocene; 427–364 ka), alluvial and lacustrine deposits of the Larevka horizon (Middle Neopleistocene; 364–334 ka), fluvial and lacustrine deposits of the Tabulda horizon (Late Neopleistocene; 57–24 ka), water-slope deposits of the Kudashevo horizon (Late Neopleistocene; 24–11 ka) and chernozem soil of the Holocene. The small and large mammals, insects, molluscs, and ostracods discovered in the deposits complete the palaeoecological characteristics of these periods. A diverse herbaceous steppe vegetation dominated during the Belaya Interglacial (a mixed coniferous forests with broad-leaved trees occurred in wet areas). The ostracoda species clearly indicate a cooling at the end of this time span. Molluscs inhabited the rivers and shores of freshwater ponds. The large mammals belong to the Middle Pleistocene fauna complex. During Larevka time span vegetation and fauna indicate cold climate conditions. The cold steppe communities typical of the beginning of this period changed gradually into communities that show an increasing role of the taiga. The ostracoda species confirm these cold conditions. Forest-steppe landscapes dominated during the second part of the Tabulda time span. Numerous ostracods as well as molluscs populated the lakes and floodplain basins. Entomological data show that the palaeoenvironment conditions were somewhat cooler than modern environment existing in the Southern Ural foreland. The large mammals of the Gornovo site belong to the Late Palaeolithic complex with the specific presence of Camelus sp. The Gornovo forest-steppe small mammalian fauna developed in cool continental climate conditions when coniferous forests grew in the river valleys and when forest-steppe landscapes dominated in the water interfluves. The artefacts are characteristic of the beginning of the Late Palaeolithic (32–24 ka). The Kudashevo time is correlated with the late Valdai (late Late Pleistocene; 24–11 ka). The herbage-Artemisia-Chenopodiaceae grassland-steppe association covered most of the territory and a Picea forest with Betula and a small quantity of broad-leaved trees grew in wet depressions. The climate at the end of this period became colder. Freshwater and terrestrial molluscs were represented by rare widespread species while the ostracoda species indicate cold conditions.

© 2014 Elsevier Ltd and INQUA. A representative mollusc fauna attributed to the late phase of the Karginian Interstadial (MIS 3) has been found in the Bol'shoj Naryn Palaeolithic site (Fore-Baikal region). The general organization of the strata at the Bol'shoj Naryn site has been established through excavations realized during the previous field seasons. It shows a modern soil made of sandy loess deposits 1m thick, dated from the Sartan glacial stage, and underlined by a high viscosity paleosol layers which is up to 1m thick developed during the Karginian Interstadial. The "cultural layer" has been correlated with the upper Karginian soil contains numerous stone tools and animal fossils. This paper focus on the mollusc assemblage attributed to the upper Karginian sediment.The mollusc assemblage (2460 determined specimens) consists of six species and five genera of terrestrial molluscs. Succinella oblonga, Pupilla muscorum and Vallonia tenuilabris are the best represented species. The molluscs suggest the existence of landscapes corresponding with humid meadows and forests located in the relief depressions or along banks of the river. Molluscs of the Bol'shoj Naryn site have been compared with equivalent mollusc complexes from Siberian and Southern Fore-Uralian localities. They display a distinctive poverty in the species composition and show similarity with the complex of the Gornovo locality (Southern Fore-Urals region). Comparison of the mollusc complex from the Bol'shoj Naryn locality with molluscs from the last glacial period also showed similarity with the complex of the Gornovo locality (Kudashevo period in the Southern Urals - last phase of the Late Valdai equivalent MIS 2). The climatic conditions which prevailed in the surroundings of the Bol'shoj Naryn locality during the late phase of the Karginian interglacial period (32-25kaBP) of the Fore-Baikal region were cooler than those existing at the same time in Europe and Southern Urals. Correlation between the data obtained after malacological investigations and other paleontological data obtained from palynology and vertebrate records suggest a moderate cold and humid climate in the Fore-Baikal region during the second part of MIS 3, with predominance of open landscapes of steppes and relatively limited taiga forest, tundra, and wetlands.

Tunka-Rex, the Tunka Radio extension at the TAIGA facility (Tunka Advanced Instrument for cosmic ray physics and Gamma Astronomy) in Siberia, has recently been expanded to a total number of 63 SALLA antennas, most of them distributed on an area of one square kilometer. In the first years of operation, Tunka-Rex was solely triggered by the co-located air-Cherenkov array Tunka-133. The correlation of the measurements by both detectors has provided direct experimental proof that radio arrays can measure the position of the shower maximum. The precision achieved so far is 40 g/cm2 , and several methodical improvements are under study. Moreover, the cross-comparison of Tunka-Rex and Tunka-133 shows that the energy reconstruction of Tunka-Rex is precise to 15 %, with a total accuracy of 20 % including the absolute energy scale. By using exactly the same calibration source for Tunka-Rex and LOPES, the energy scale of their host experiments, Tunka-133 and KASCADE-Grande, respectively, can be compared even more accurately with a remaining uncertainty of about 10 %. The main goal of Tunka-Rex for the next years is a study of the cosmic-ray mass composition in the energy range above 100 PeV: For this purpose, Tunka-Rex now is triggered also during daytime by the particle detector array Tunka-Grande featuring surface and underground scintillators for electron and muon detection.

The Tunka Radio Extension (Tunka-Rex) is a radio detector at the TAIGA facility located in Siberia nearby the southern tip of Lake Baikal. Tunka-Rex measures air-showers induced by high-energy cosmic rays, in particular, the lateral distribution of the radio pulses. The depth of the air-shower maximum, statistically depends on the mass of the primary particle, is determined from the slope of the lateral distribution function (LDF). Using a model-independent approach, we have studied possible features of the one-dimensional slope method and tried to find improvements for the reconstruction of primary mass. To study the systematic uncertainties given by different primary particles, we have performed simulations using the CONEX and CoREAS software packages of the recently released CORSIKA v7.5 including the modern high-energy hadronic models QGSJet-II.04 and EPOS-LHC. The simulations have shown that the largest systematic uncertainty in the energy deposit is due to the unknown primary particle. Finally, we studied the relation between the polarization and the asymmetry of the LDF.

We review the present status of the Baikal Neutrino Project and present the results obtained with the deep underwater neutrino telescope NT-200., Comment: 4 pages, 3 figures. Presented at TAUP 2001 (7th international workshop on Topics in Astroparticle and Underground Physics), Sep. 2001, Laboratori Nazionali del Gran Sasso, Assergi, Itali

Mesenchymal stem cells (MSC) have been widely used in different areas of medicine because of their immunosupressive properties and influence on regeneration of the damaged tissues. The objective of this study was to examine the kinetics of growth (MSC from 4-3 passages had significantly higher proliferative activity compared with cultures of 10-12 passages), changes in immunophenotypic characteristics of human MSC in early (3-4) and late (10-12) passages when cultured in vitro as well as study of genetic stability. In the analyzed cultures of MSC was found normal karyotype (46, XY or 46, XX). In most of cultures studied MSC karyotype and the level of aneuploidy remained unchanged even after prolonged culturing. The author's experience of ex vivo expansion of MSC using both standard medium DMEM with the supplementation of fetal bovine serum (FBS) and serum-free medium MesenCult MSC Basal Medium (Human) (StemCell technologies Inc.) with addition of Mesenchymal Stem Cell Stimulatory Supplements (Human) is presented. The influence of the type of medium on the growth and immunophenotype of MSC is analyzed. The study found that when cultured in serum-free medium proliferative potential of MSCs was lower.

We rewiew the present status of the Baikal Neutrino Project and present the results of a search for high energy neutrinos with the detector intermediate stage NT-96., Comment: 3 pages, 2 figures, to appear in the Proceedings of Sixth International Workshop on Topics in Astroparticle and Underground Physics (TAUP99), September 6-10, 1999, Pais, France

We report theoretical and experimental results of on-going feasibility studies to detect cosmic neutrinos acoustically in Lake Baikal. In order to examine ambient noise conditions and to develop respective pulse detection techniques a prototype device was created. The device is operating at a depth of 150 m at the site of the Baikal Neutrino Telescope and is capable to detect and classify acoustic signals with different shapes, as well as signals from neutrino-induced showers., Comment: 4 pages, 6 figures, Proceedings of the 31st ICRC, Lodz, Poland, July 2009

Baikal-GVD will be a neutrino telescope at the cubic-kilometer scale in Lake Baikal. The first out of 10-12 clusters of the first phase of GVD has been deployed and commissioned in April 2015. This paper describes design and implementation of the dataacquisition system of GVD.

Neonatal screening for congenital hypothyroidism (CH) has proved its efficacy as a method of early diagnostics of the disorder. It helps to start treatment on time and prevent disability. The estimation of arrangement and efficacy of neonatal screening for CH in the scale of a region proved to be actual and determined the purpose of the research. Neonatal screening for CH in the Udmurt Republic (UR) has been carried out since 1995. By the beginning of 2011 twenty two thousand four hundred and ninety one children have been examined. The disease was revealed and confirmed in 63 newborns. The incidence of CH is 1:3532 neonates. Before 2005 only 64,3% of neonates underwent screening procedure, while since 2005 – 99,0% of them. From 1995 till 2004 (the first stage) seven cases of late (retarded) diagnostics of the CH were registered while since 2005 the diagnosis of CH has been made basing on the findings of screening in all cases. Nowadays general temporal characteristics of screening, the average terms of beginning the treatment for CH in the Udmurt Republic correspond to required indices. Seventy one patients with CH were included into the republican register. Prevalence of the disease made 22,9 per 100 000 children from 0 to17 years. Stable clinico-metabolic compensation was reached in 75% of patients. Physical, neuro(psychic and sexual development of them, as well as the indices of thyroid function corresponded to the age norms. In the majority of cases diagnosis was made according to the data of neonatal screening, which allowed to reach more optimal indices of medico(social adaptation in comparison with those patients whose diagnosis was made basing on clinical symptomatology and the treatment was taken up much later.

The Tunka Radio Extension (Tunka-Rex) is a digital antenna array located in the Tunka Valley in Siberia, which measures the radio emission of cosmic-ray air-showers with energies up to EeV. Tunka-Rex is externally triggered by the Tunka-133 air-Cherenkov timing array (during nights) and by the Tunka-Grande array of particle detectors (remaining time). These three arrays comprise the cosmic-ray extension of the Tunka Advanced Instrument for cosmic rays and Gamma Astronomy (TAIGA). The configuration and analysis pipeline of Tunka-Rex have significantly changed over its runtime. Density of the antennas was tripled and the pipeline has become more developed forming now sophisticated piece of reconstruction software. During its lifecycle Tunka-Rex has demonstrated that a cost-effective and full duty-cycle radio detector can reconstruct the energy and shower maximum with a precision comparable to optical detectors. Moreover, it was shown that cosmic-ray instruments, that use different detection techniques and are placed in different locations, can be cross-calibrated via their radio extensions. These results show the prospects of application of the radio technique for future large-scale experiments for cosmic-ray and neutrino detection. For the time being Tunka-Rex has ceased active measurements and focuses on the data analysis and publication of corresponding software and data in an open-access data center with online analysis features. In this report we present the current status of the array and give an overview of the results achieved during these years as well as discuss upcoming improvements in instrumentation and data analysis, which can be applied for the future radio arrays., Presented at the 36th International Cosmic Ray Conference (ICRC 2019)

Tunka-Rex (Tunka Radio Extension) is an antenna array for cosmic-ray detection located in Siberia. Previous studies of cosmic rays with Tunka-Rex have shown high precision in determining the energy of the primary particle and the possibility to reconstruct the depth of the shower maximum. The next step is the reconstruction of the mass composition and the energy spectrum of cosmic rays. One of the main problems appearing within this task is to estimate the detection efficiency of the instrument, and the exposure of the observations. The detection efficiency depends on properties of the primary cosmic rays, such as energy and arrival direction, as well as on many parameters of the instrument: density of the array, efficiency of the receiving antennas, signal-detection threshold, data-acquisition acceptance, and trigger properties. More than that, the configuration of detector changes with time. During the measurements some parts of the detector can provide corrupted data or sometimes do not operate. All these features should be taken into account for an estimation of the detection efficiency. For each energy and arrival direction we estimate the detection probability and effective area of the instrument. To estimate the detection probability of a shower we use a simple Monte Carlo model, which predicts the size of the footprint of the radio emission as function of the primary energy and arrival direction (taking into account the geometry of Earth's magnetic field). Combining these approaches we calculate the event statistics and exposure for each run. This is the first accurate study of the exposure for irregular large-scale radio arrays taking into account most important features of detection, which will be used for the measurement of primary cosmic-ray spectra with Tunka-Rex., Proceedings of the 35th ICRC 2017, Busan, Korea

The Tunka Radio Extension (Tunka-Rex) is a digital antennaarray (63 antennas distributed over≈1 km2) co-located with the TAIGAobservatory in Eastern Siberia. Tunka-Rex measures radio emission ofair-showers induced by ultra-high energy cosmic rays in the frequencyband of 30-80 MHz. Air-shower signal is a short (tens of nanoseconds)broadband pulse. Using time positions and amplitudes of these pulses,we reconstruct parameters of air showers and primary cosmic rays. Theamplitudes of low-energy event (E