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This study is aimed at determining the parameters and biomechanical analysis of their impact on the static arm strength in children with impaired posture as poor kyphotic posture, lordotic poor posture and children with flat feet. A transversal study included a sample of 67 children on the territory of the municipality of Subotica. The structure of the sample is as follows: 22 subjects with impaired kyphotic posture, 18 patients with impaired lordotic posture, and 27 subjects with flat feet. Measuring the level of static arm strength was done by the standardized "folding endurance" test. Observing the morphological development of children with kyphotic, lordotic poor posture and flat feet determined statistically significant differences in biomechanical variables.

We have identified a population of primitive cells in normal human (h) as well as murine (m) and rat (r), postnatal bone marrow (BM) that have, at the single cell level, multipotent differentiation and extensive proliferation potential, which we named Multipotent Adult Progenitor Cell or MAPC. MAPC differentiate in vitro into most mesodermal cell types (cells with characteristics of osteoblasts, chondroblasts, fibroblasts, adipocytes, skeletal, smooth and cardiac myoblasts, endothelial cells), as well as cells with neuroectodermal and with endodermal features. Using retroviral marking we have shown that multi-lineage differentiation is derived from single MAPC. MAPC express active telomerase and can undergo 100+ cell doublings without telomere shortening, suggesting that they do not senesce. MAPC express oct-4 mRNA. MAPC engraft in vivo and persist for 6+ months, differentiate into hematopoietic and epithelial cells in response to local “cues”, and contribute to all somatic cell types when injected in the blastocyst. The finding that stem cells exist in post-natal tissues with previously unknown proliferation and differentiation potential opens up the possibility of using autologous stem cells to treat a host of degenerative, traumatic or congenital diseases.

Mesenchymal stem cells were isolated and a subpopulation of cells--multipotent adult progenitor cells--were identified that have the potential for multilineage differentiation. Their ability to engraft and differentiate in vivo is under investigation. ispartof: pages:231-235 ispartof: Annals of the New York Academy of Sciences vol:938 pages:231-235 ispartof: 3rd International Conference on Hematopoietic Stem Cells: Genetics and Medicine location:GERMANY, TUBINGEN date:14 Sep - 16 Sep 2000 status: published