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This chapter discusses strategies for designing selective excitation (or inversion) pulses, and the applications of such pulses to multidimensional experiments for assignment of resonances, derivation of coupling constants, and determination of relaxation rates. The development of sophisticated pulses for selective excitation and inversion has triggered an explosion in the development of techniques using selective manipulations. These techniques can aid at all stages in structure determination, from assignment to the determination of coupling constants and relaxation rates. The number of experiments and their relative efficiency are growing rapidly and are likely to become an indispensable tool in cases where a structure does not yield to routine nonselective approaches. The idea behind all nuclear magnetic resonance (NMR) experiments which utilize selective pulses is that more information can be obtained if the spectral region affected by the pulses in the experiment is reduced.