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1. The Effect of Anti TNF-Alpha Therapy in Nutritional Status and Serum Leptin Levels in Patients with Ankylosing Spondylitis

Author

Kadayifci Fatma Zehra, Onat Ahmet Mesut, and Gezmen Karadag Makbule

Subjects
medicine.medical_specialty, Ankylosing spondylitis, business.industry, Leptin, Nutritional status, Anthropometry, medicine.disease, Anti-TNF-alpha therapy, Endocrinology, Internal medicine, Serum leptin, Medicine, In patient, Tumor necrosis factor alpha, business
Abstract

The objective of this study was to investigate the effect of anti TNF-α therapy on nutritional status and serum leptin levels in patients with ankylosing spondylitis. This study was conducted on two groups of AS patients. First group included 48 patients receiving anti TNF-α treatment together with NSAID. Second group included 48 patients receiving only NSAID treatment. Descriptive information, food consumption and physical activity about patients collected with a survey. Anthropometric measurements were measured with body analysis scale and serum leptin was also assessed. As results, there was significant difference in daily energy consumption between both men and women with and without anti TNF-α treatment (2399 kcal and 2069 kcal p=0,036, 2102 kcal and 1659 kcal p=0,001). There was no significant difference of serum leptin levels between patients receiving anti TNF-α and only NSAID treatment (p>0,05). However, the women's leptin levels (12,4±8,2 ng/mL) were significantly higher compared to men (3,7±3,02 ng/mL). There was positive correlation of serum leptin levels, BMI and body fat mass between men and women with and without anti TNF-α treatment. The anthropometric measurements between both men and women groups were not significant (p>0,05). No statistical difference was found between the physical activity assessments of the groups (p>0,05). In conclusion, there was no significant effect of anti-TNF-α treatment in AS patients on serum leptin levels, physical activity, and anthropometric measurements. However, anti TNF-α therapy receiving patients’ daily energy and nutrient consumption were higher. This study showed anti TNF-α therapy has been effective on food consumption of patients with ankylosing spondylitis.

Published
2017
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2. Familial Mediterranean Fever and Glomerulonrphritis: A Case Report

Author

ZENGİN, Orhan, TÜRKBEYLER, İbrahim Halil, BABACAN, Taner, PEHLİVAN, Yavuz, and ONAT, Ahmet Mesut

Subjects
Familial Mediterranean fever,kidney involvement,glomerulonephritis
Abstract

Familial mediterranean fever is characterized by recurrent attacks of fever and polyserositis. Familial mediterranean fever is an autosomal recessive disease. Familial mediterranean fever is commonly seen in Jewish, Arab, Turkish and Armenian. The most important and prognosis-determining complication is kidney involvement. The most common cause of kidney involvement is AA type amyloidosis. Effective ad common use of colchicine decreased amyloidosis frequency when compared to before. It has been reported that frequency of amyloidosis in patients who don't use colchicine is around 20-25% in our country. During the course of familial mediterranean fever, renal pathologies such as glomerulonephritis can be seen other than amyloidosis. Here we present a patient with familial mediterranean fever and membranoproliferative glomerulonephritis.

Published
2012

3. Diagnosis of Systemic Lupus Erythematosus in a Patient with Generalized Lymphadenopathy: A Case Report

Author

TÜRKBEYLER, İbrahim Halil, PEHLİVAN, Yavuz, ÇÖMEZ, Gazi, ZENGİN, Orhan, GÖKTEPE, Fatih, and ONAT, Ahmet Mesut

Subjects
Lymphadenopathy,systemic lupus erythematosus, Lenfadenopati,sistemik lupus eritematozis,başlangıç semptom, skin and connective tissue diseases
Abstract

Lymphadenopathy (LAP) is defined as abnormality in the size and character of lymph node. Lymphadenopathy emerges due to increase of inflammatory cells in lymph node or invasion of these cells in the lymph node. Lymphadenopathy can occur in any age group, in symptomatic or asymptomatic patients, and in a single site or at multiple sites. Causes of generalized lymphadenopathy include infections, autoimmune diseases, malignancies, histiocytoses, storage diseases, benign hyperplasia, and drug reactions. In LAP etiology, collagen tissue diseases hold an important place. The most common autoimmune causes of LAP are rheumatoid arthritis, systemic lupus erythematosus (SLE) and Sjogren syndrome. In this case, we presented a case who was researched for generalized lymphadenopathy and diagnosed with SLE. SLE diagnosis should be considered in patients researched for lymphadenopathy etiology., Lenfadenopati (LAP), lenf düğümünün boyut ve karakterindeki anormallik olarak tanımlanır. Lenfadenopatineoplastik veya inflamatuar hücrelerin lenf nodunda çoğalması veya lenf nodunu invazyonu sonucu oluşabilir.Lenfadenopati geniş bir hastalık tablosu sonucunda gelişebilir. Yaygın lenfadenopati sebepleri arasındaenfeksiyonlar, otoimmun hastalıklar, malignensiler, histiyositozlar, depo hastalıkları, hiperplaziler ve ilaçetkileşimleri sayılabilir. Lenfadenopati etyolojisinde kollajen doku hastalıkları önemli yer tutmaktadır. En sıklenfadenopatiye neden olan otoimmun hastalıklar romatoid artrit, sistemik lupus eritematozis (SLE) ve Sjögrensendromudur. Bu olguda yaygın lenfadenopati nedeni ile araştırılan ve SLE tanısı alan bir olguyu sunduk.Lenfadenopati nedeniyle tetkik edilen hastalarda kollajen doku hastalıklarını ve özellikle de SLE'u göz önündebulundurmamız gerektiğini bu yazıda vurgulamak istedik

Published
2011

4. Validation of New 2012 EULAR/ACR Classification Criteria for Polymyalgia Rheumatica: Comparison with the Previous Criteria in a Prospective Multi-Center Study

Author

Ozen, Gulsen, Bas, Seda, Unal, Ali Ugur, Kimyon, Gezmis, Onat, Ahmet Mesut, Can, Meryem, Mengi, Alperen, ALI SAHIN, Yilmaz, Sema, Keskin, Havva, Murat, Sadiye, Balkarli, Ayse, Cobankara, Veli, Pamuk, Omer Nuri, Cagatay, Yonca, Yilmaz, Neslihan, Yagci, Ilker, Atagunduz, Pamir, Aydin, Sibel Z., Inanc, Nevsun, Direskeneli, Haner, [Ozen, Gulsen -- Bas, Seda -- Unal, Ali Ugur -- Yagci, Ilker -- Atagunduz, Pamir -- Inanc, Nevsun -- Direskeneli, Haner] Marmara Univ, Sch Med, Istanbul, Turkey -- [Kimyon, Gezmis -- Onat, Ahmet Mesut] Gaziantep Univ, Sch Med, Gaziantep, Turkey -- [Can, Meryem -- Mengi, Alperen] Fatih Sultan Mehmet Educ & Res Hosp, Istanbul, Turkey -- [Sahin, Ali] Cumhuriyet Univ, Fac Med, Sivas, Turkey -- [Yilmaz, Sema] Selcuk Univ, Sch Med, Konya, Turkey -- [Keskin, Havva -- Murat, Sadiye] Goztepe Medeniyet Univ, Fac Med, Istanbul, Turkey -- [Balkarli, Ayse -- Cobankara, Veli] Pamukkale Univ, Sch Med, Denizli, Turkey -- [Pamuk, Omer Nuri] Trakya Univ, Sch Med, Edirne, Turkey -- [Cagatay, Yonca -- Yilmaz, Neslihan] Bilim Univ, Fac Med, Istanbul, Turkey -- [Aydin, Sibel Z.] Koc Univ, Fac Med, Istanbul, Turkey, and Ozen, Gulsen -- 0000-0002-5423-393X

Abstract

WOS: 000344384906005, …

5. Dapsa-28 May be Used Instead of Dapsa-66/68 in Psoriatic Arthritis

Author

Kalyoncu, Umut, Bayndir, Ozun, Oksuz, Mustafa Ferhat, Kimyon, Gezmis, Erden, Abdulsaniet, Yavuz, Sule, Cetin, Gozde, Kucuksahin, Orhan, Kilic, Levent, Omma, Ahmet, Ozisler, Cem, Solmaz, Dilek, Onat, Ahmet Mesut, Kisacik, Bunyamin, Bakirli, Duygu Ersozlu, Cinar, Muhammet, Tufan, Abdurrahman, Yildiz, Fatih, Mercan, Ridvan, Kasifoglu, Timucin, Yilmazer, Bark, Yilmaz, Sema, Aksu, Kenan, Erten, Sukran, Sayarlioglu, Mehmet, Dalkilic, Ediz, Akar, Servet, Acikel, Cengizhan, Muge Aydin Tufan, Balkarli, Ayse, Kasapoglu-Gunal, Esen, Senel, Soner, Kobak, Senol, Duruoz, M. Tuneay, Dopru, Atalay, Tarhan, E. Figen, Can, Meryem, Akyol, Lutfi, Pehlevan, Seval, Erhasan, Funda, Arslan, Fatos, Kucuk, Adem, Gonullu, Emel, Kahasakal, Yasemin, Sahin, Mehmet, Atakan, Nilgun, and Aydin, Sihel Z.

6. A Nationwide Experience with the Off Label Use of Interleukin 1 Targeting Treatment in Familial Mediterranean Fever Patients

Author

Akar, Servet, Cetin, Pinar, Kalyoncu, Umut, Karadag, Omer, Sari, Ismail, Cinar, Muhammed, Yilmaz, Sedat, Onat, Ahmet Mesut, Kisacik, Bunyamin, Erden, Abdulsamet, Balkarli, Ayse, Kucuksahin, Orhan, Oner, Sibel Yilmaz, Senel, Soner, Tufan, Abdurrahman, Direskeneli, Haner, Oksuz, Mustafa Ferhat, Pehlivan, Yavuz, Bayndir, Ozun, Keser, Gokhan, kenan aksu, Omma, Ahmet, Kasifoglu, Timucin, Unal, Ali Ugur, Yildiz, Fatih, Balci, Mehmet Ali, Yavuz, Sule, Erten, Sukran, Ozgen, Metin, Sayarlioglu, Mehmet, Dogru, Atalay, Cetin, Gozde Yildirim, Alibaz-Oner, Fatma, Tezcan, Mehmet Engin, Pamuk, Omer Nuri, and Onen, Fatos

7. Items of Yamaguchi Criteria Might be Associated with Disease Severity and Prognosis in Adult-Onset Still's Disease

Author

Kalyoncu, Umut, Solmaz, Dilek, Emmungil, Hakan, Yazici, Ayten, Kasifoglu, Timucin, Kimyon, Gezmis, Balkarli, Ayse, Bes, Cemal, Ozmen, Mustafa, Alibaz-Oner, Fatma, Erten, Sukran, Cagatay, Yonca, Cetin, Gozde, Yilmaz, Sedat, Yildiz, Fatih, Pamuk, Omer Nuri, Kucuksahin, Orhan, Kilic, Levent, Erden, Abdulsamet, Yazisiz, Veli, Karadag, Omer, Koca, Suleyman Serdar, Hayran, Mutlu, Akar, Servet, Aksu, Kenan, Akkoc, Nurullah, Keser, Gokhan, Emel Gönüllü, Kisacik, Bunyamin, Onat, Ahmet Mesut, Soy, Mehmet, Inanc, Nevsun, Direskeneli, Haner, Sayarlioglu, Mehmet, Erken, Eren, Turgay, Murat, Cefle, Ayse, Ertenli, Ihsan, and Pay, Salih

8. Is It Possible to Identify Psoriasis Patients Who Will Develop Axial Disease? Real Life Data from Psart (Psoriatic Arthritis Registry of Turkey)

Author

Aydin, Sibel Z., Bayndaer, Ozun, Yilmazer, Baris, Aksu, Kenan, Dalkilic, Ediz, Oksuz, Mustafa Ferhat, Tarhan, E. Figen, Can, Meryem, Kucuksahin, Orhan, Kimyon, Gezmis, Akyol, Lutfi, Onat, Ahmet Mesut, Kisacik, Bunyamin, Erden, Abdulsamet, Omma, Ahmet, Bakirli, Duygu Ersozlu, Ozisler, Cem, Gonullu, Emel, Pehlevan, Seval, Solmaz, Dilek, Cinar, Muhammet, Cetin, Gozde, Tufan, Abdurrahman, Tufan, Muge Aydin, Kilic, Levent, Erten, Sukran, Kasifoglu, Timucin, Kobak, Senol, Senel, Soner, Akar, Servet, Ozgen, Metin, Kasapoglu-Gunal, Esen, Yazisiz, Veli, Yilmaz, Sedat, Donmez, Salim, Dogan, Aesmail, Koseoglu, Hamide Kart, Erbasan, Funda, Yildiz, Fatih, Bes, Cemal, Balkarli, Ayse, Sahin, Ali, ridvan mercan, Arslan, Fatos, Dogru, Atalay, Pay, Salih, Yavuz, Sule, Cakir, Necati, Kabasakal, Yasemin, and Kalyoncu, Umut

10. Disease Activity Indices and Body Mass Index: Cross-Sectional Analysis of a Large Psoriatic Arthritis Cohort

Author

Kalyoncu, Umut, Bayndar, Ozun, Yilmazer, Baris, Dalkilic, Ediz, Aksu, Kenan, Oksuz, Mustafa Ferhat, Tarhan, E. Figen, Can, Meryem, Kucuksahin, Orhan, Kimyon, Gezmis, Akyol, Lutfi, Onat, Ahmet Mesut, Kisacik, Bunyamin, Erden, Abdulsamet, Omma, Ahmet, Bakirli, Duygu Ersozlu, Ozisler, Cem, Gonullu, Emel, Pehlevan, Seval, Solmaz, Dilek, Cinar, Muhammet, Cetin, Gozde, Tufan, Abdurrahman, Tufan, Muge Aydin, Kilic, Levent, Erten, Sukran, Kasifoglu, Timucin, Kobak, Senol, Senel, Soner, Akar, Servet, Ozgen, Metin, Kasapoglu-Gunal, Esen, Yazisiz, Veli, Yilmaz, Sedat, Donmez, Salim, Dogan, Asmail, Koseoglu, Hamide Kart, Erbasan, Funda, Yildiz, Fatih, Bes, Cemal, Balkarli, Ayse, ALI SAHIN, Mercan, Ridvan, Arslan, Fatos, Dogru, Atalay, Pay, Salih, Yavuz, Sule, Cakir, Necati, Kabasakal, Yasemin, and Aydin, Sibel Z.

11. Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study

Author

Sharon A. Chung, Gökhan Keser, Ayten Yazici, Zeynep Ozbalkan, R. Maughan, Servet Akar, Fatma Alibaz-Oner, Nurullah Akkoc, Kathleen McKinnon-Maksimowicz, Patrick Coit, Güher Saruhan-Direskeneli, Chris Wallace, Omer Karadag, Muge Bicakcigil, Antoine G. Sreih, Ahmet Mesut Onat, Paul A. Monach, Ying Sun, Kenan Aksu, Carol A. Langford, Mehmet Akif Ozturk, Izzet Fresko, Eren Erken, Lindsay Lally, Lindsy J. Forbess, Christian Pagnoux, Ayse Cefle, Ediz Dalkilic, Timothy J. Vyse, Veli Cobankara, Peter C. Grayson, Guillermo Reales, David Cuthbertson, Philip Seo, Gozde Yildirim Cetin, Curry L. Koening, Sibel P. Yentür, Yaşar Karaaslan, Lourdes Ortiz-Fernández, Nilufer Alpay-Kanitez, Bunyamin Kisacik, Xiufang Kong, Sibel Zehra Aydin, Enrico Tombetti, Sule Yavuz, Lindi Jiang, Fatos Onen, Allan P. Kiprianos, Nurşen Düzgün, Nader Khalidi, Justin C. Mason, Huiyong Chen, Aşkın Ateş, Angelo A. Manfredi, Murat Inanc, Sevil Kamali, Sema Kaymaz-Tahra, Steven R. Ytterberg, Timuçin Kaşifoğlu, Emire Seyahi, Elena Baldissera, Deborah S. Cunninghame-Graham, Sedat Kiraz, Jason M. Springer, Peter A. Merkel, Haner Direskeneli, Jonathan D. Wren, Kenneth J. Warrington, Carol A. McAlear, Amr H. Sawalha, Huseyin T. E. Ozer, Wallace, Chris [0000-0001-9755-1703], Apollo - University of Cambridge Repository, Ortiz-Fernandez, Lourdes, Saruhan-Direskeneli, Guher, Alibaz-Oner, Fatma, Kaymaz-Tahra, Sema, Coit, Patrick, Kong, Xiufang, Kiprianos, Allan P., Maughan, Robert T., Aydin, Sibel Z., Aksu, Kenan, Keser, Gokhan, Kamali, Sevil, Inanc, Murat, Springer, Jason, Akar, Servet, Onen, Fatos, Akkoc, Nurullah, Khalidi, Nader A., Koening, Curry, Karadag, Omer, Kiraz, Sedat, Forbess, Lindsy, Langford, Carol A., McAlear, Carol A., Ozbalkan, Zeynep, Yavuz, Sule, Cetin, Gozde Yildirim, Alpay-Kanitez, Nilufer, Chung, Sharon, Ates, Askin, Karaaslan, Yasar, McKinnon-Maksimowicz, Kathleen, Monach, Paul A., Ozer, Huseyin T. E., Seyahi, Emire, Fresko, Izzet, Cefle, Ayse, Seo, Philip, Warrington, Kenneth J., Ozturk, Mehmet A., Ytterberg, Steven R., Cobankara, Veli, Onat, Ahmet Mesut, Duzgun, Nursen, Bicakcigil, Muge, Yentur, Sibel P., Lally, Lindsay, Manfredi, Angelo A., Baldissera, Elena, Erken, Eren, Yazici, Ayten, Kisacik, Bunyamin, Kasifoglu, Timucin, Dalkilic, Ediz, Cuthbertson, David, Pagnoux, Christian, Sreih, Antoine, Reales, Guillermo, Wallace, Chris, Wren, Jonathan D., Cunninghame-Graham, Deborah S., Vyse, Timothy J., Sun, Ying, Chen, Huiyong, Grayson, Peter C., Tombetti, Enrico, Jiang, Lindi, Mason, Justin C., Merkel, Peter A., Direskeneli, Haner, Sawalha, Amr H., Ortiz-Fernandez, L., Saruhan-Direskeneli, G., Alibaz-Oner, F., Kaymaz-Tahra, S., Coit, P., Kong, X., Kiprianos, A. P., Maughan, R. T., Aydin, S. Z., Aksu, K., Keser, G., Kamali, S., Inanc, M., Springer, J., Akar, S., Onen, F., Akkoc, N., Khalidi, N. A., Koening, C., Karadag, O., Kiraz, S., Forbess, L., Langford, C. A., Mcalear, C. A., Ozbalkan, Z., Yavuz, S., Cetin, G. Y., Alpay-Kanitez, N., Chung, S., Ates, A., Karaaslan, Y., McKinnon-Maksimowicz, K., Monach, P. A., Ozer, H. T. E., Seyahi, E., Fresko, I., Cefle, A., Seo, P., Warrington, K. J., Ozturk, M. A., Ytterberg, S. R., Cobankara, V., Onat, A. M., Duzgun, N., Bicakcigil, M., Yentur, S. P., Lally, L., Manfredi, A. A., Baldissera, E., Erken, E., Yazici, A., Kisacik, B., Kasifoglu, T., Dalkilic, E., Cuthbertson, D., Pagnoux, C., Sreih, A., Reales, G., Wallace, C., Wren, J. D., Cunninghame-Graham, D. S., Vyse, T. J., Sun, Y., Chen, H., Grayson, P. C., Tombetti, E., Jiang, L., Mason, J. C., Merkel, P. A., Direskeneli, H., Sawalha, A. H., Ege Üniversitesi, [Belirlenecek], Imperial College Healthcare NHS Trust- BRC Funding, and İç Hastalıkları

Subjects
Male, 0301 basic medicine, genetic association, PROTEIN, Integrin, Genome-wide association study, Disease, DISEASE, vasculitis, Genetic Risk, ACTIVATION, 0302 clinical medicine, LEFLUNOMIDE, Polymorphism (computer science), CRITERIA, GWAS, skin and connective tissue diseases, 11 Medical and Health Sciences, Genetics (clinical), Genetics & Heredity, Genetics, PSORIASIS, genetic risk scroe, Classification, HLA, Polydom, Female, Vasculitis, Leflunomide, epigenetic, vasculitis genetic association, POLYDOM, Activation, GENETIC RISK, Human leukocyte antigen, Biology, eQTL, Polymorphism, Single Nucleotide, Article, CLASSIFICATION, 03 medical and health sciences, medicine, Psoriasis, Humans, Genetic Predisposition to Disease, cardiovascular diseases, Tıp uygulaması, Genetic association, 030203 arthritis & rheumatology, Protein, [No Keywords], Case-control study, 06 Biological Sciences, Inflammatory Bowel Diseases, medicine.disease, Criteria, Takayasu Arteritis, 030104 developmental biology, [No Keyword], Case-Control Studies, Expression quantitative trait loci, chromatin interaction, INTEGRIN, Genome-Wide Association Study
Abstract

Takayasu arteritis is a rare inflammatory disease of large arteries. We performed a genetic study in Takayasu arteritis comprising 6,670 individuals (1,226 affected individuals) from five different populations. We discovered HLA risk factors and four non-HLA susceptibility loci in VPS8, SVEP1, CFL2, and chr13q21 and reinforced IL12B, PTK2B, and chr21q22 as robust susceptibility loci shared across ancestries. Functional analysis proposed plausible underlying disease mechanisms and pinpointed ETS2 as a potential causal gene for chr21q22 association. We also identified >60 candidate loci with suggestive association (p < 5 x 10(-s)) and devised a genetic risk score for Takayasu arteritis. Takayasu arteritis was compared to hundreds of other traits, revealing the closest genetic relatedness to inflammatory bowel disease. Epigenetic patterns within risk loci suggest roles for monocytes and B cells in Takayasu arteritis. This work enhances understanding of the genetic basis and pathophysiology of Takayasu arteritis and provides clues for potential new therapeutic targets., National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) [R01 AR070148]; National Institute of Arthritis and Musculoskeletal and Skin DiseasesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) [U54 AR057319, U01 AR51874 04]; National Center for Research ResourcesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Research Resources (NCRR) [U54 RR019497]; Office of Rare Diseases Research of the National Center for Advancing Translational Sciences; Imperial College, National Institute for Health Research, Biomedical Research Centre; Wellcome TrustWellcome TrustEuropean Commission [WT107881]; Medical Research CouncilUK Research & Innovation (UKRI)Medical Research Council UK (MRC)European Commission [MC_UU_00002/4], This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health grant R01 AR070148 to A.H.S. The Vasculitis Clinical Research Consortium has received support from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319 and U01 AR51874 04), the National Center for Research Resources (U54 RR019497), and the Office of Rare Diseases Research of the National Center for Advancing Translational Sciences. J.C.M., A.P.K., and R.M.M. acknowledge support from the Imperial College, National Institute for Health Research, Biomedical Research Centre. C.W. and G.R. acknowledge support from The Wellcome Trust (WT107881) and the Medical Research Council (MC_UU_00002/4). This work was supported by the use of study data downloaded from the dbGaP website, under dbGaP: phs000272.v1.p1, phs000431.v2.p1, phs000583.v1.p1, and phs000444.v1.p1.

Published
2021
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12. Impaired quality of life, disability and mental health in Takayasu's arteritis

Author

Neslihan Yilmaz, Fatos Onen, Fatma Alibaz Öner, Sedat Kiraz, B. Kisacik, Meryem Can, Ahmet Mesut Onat, Eren Erken, Baris Yilmazer, Timuçin Kaşifoğlu, Birkan Ilhan, Veli Cobankara, Kenan Aksu, Fatih Yildiz, Vedat Gerdan, Hakan Emmungil, Gökhan Keser, Gezmiş Kimyon, Gonca Mumcu, Servet Akar, Şule Yaşar Bilge, Ayse Cefle, Haner Direskeneli, Melike Kalfa, Omer Karadag, İç Hastalıkları, Çukurova Üniversitesi, Yilmaz, Neslihan, Can, Meryem, Oner, Fatma Alibaz, Kalfa, Melike, Emmungil, Hakan, Karadag, Omer, Yildiz, Fatih, Kimyon, Gezmis, Yilmazer, Baris, Gerdan, Vedat, Bilge, Sule Yasar, Ilhan, Birkan, Cobankara, Veli, Kasifoglu, Timucin, Cefle, Ayse, Kisacik, Bunyamin, Onat, Ahmet Mesut, Akar, Servet, Onen, Fatos, Erken, Eren, Kiraz, Sedat, Aksu, Kenan, Keser, Gokhan, Mumcu, Gonca, Direskeneli, Haner, and Ege Üniversitesi

Subjects
Takayasu's arteritis, Turkey, PROGRESSION, Anxiety, Hospital Anxiety and Depression Scale, DISEASE-ACTIVITY, Disability Evaluation, Quality of life, VASCULITIS, anxiety disorder, Pharmacology (medical), Function, Depression (differential diagnoses), ANCA associated vasculitis, adult, aorta arch syndrome, article, Middle Aged, humanities, female, priority journal, depression, medicine.symptom, CLINICAL-TRIALS, mental health, medicine.medical_specialty, SF-36, Psychometrics, DISORDERS, SURVEY SF-36, HOSPITAL ANXIETY, WEGENERS-GRANULOMATOSIS, male, Rheumatology, Internal medicine, medicine, Humans, controlled study, Arteritis, human, outcome assessment, Psychiatric Status Rating Scales, business.industry, OUTCOME MEASURES, Mental status, medicine.disease, Mental health, Takayasu Arteritis, major clinical study, social status, Cross-Sectional Studies, disability, Short Form 36, Physical therapy, business, disease activity
Abstract

WOS: 000325997900026, PubMed ID: 23873821, Objective. Patient-reported outcomes (PROs) are increasingly accepted to be among the major tools for outcome assessment in rheumatic disorders. In this study we aimed to assess quality of life (QoL), disability, anxiety and depression in patients with Takayasu's arteritis (TAK). Methods. Patients followed with the diagnosis of TAK (n = 165) and healthy controls (HCs) (n = 109) were enrolled to the study. The 36-item Short Form Health Survey (SF-36) and hospital anxiety and depression scales (HADS) were used to assess QoL and mental status together with HAQ for disability. Results. In SF-36 subscale assessment, all items were observed to be statistically lower in TAK patients; similarly HAQ scores were also higher (P < 0.001) in this group. In mental assessment, anxiety was found to be more common in TAK patients [90 (54.5%) vs 38 (34.9%), P = 0.001]. Depression also tended to be higher in TAK patients [70 (66.7%) vs 35 (33.3%)], without reaching significance (P = 0.086). Most of the SF-36 subgroup parameters were lower in TAK patients with active disease. Patients having anxiety and depression or with high HAQ scores reported worse SF-36 scores. In multivariate analysis, HADS-A, HADS-D and HAQ were associated with most SF-36 subscales. Conclusion. PROs demonstrate that not only general health but also physical and social functioning with physical role limitations and mental health parameters were impaired in TAK. Our results, especially in active disease, suggest that PROs such as SF-36 can be core domains of disease assessment in TAK, similar to ANCA-associated vasculitides.

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