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Background : The COVID-19 pandemic has been described to have significant effects on the mental health and emotional well-being of people all over the world generally. This study aimed at describing the set up and functions of the psychosocial support service for the COVID-19 response in Lagos South West Nigeria.Methods: A retrospective and descriptive overview of the psychosocial support for covid-19 patients supported in Lagos, Nigeria over a four-month period. Remote interventions given included Psychological first aid, counselling, psycho pharmacology, and virtual support group sessions. Results: The Psychosocial care provided was a part of the Covid-19 outbreak response strategy in Lagos State, Nigeria. Over 43,000 support calls were made to Covid-19 positive persons; 1,316 hospitalised patients were supported remotely during isolation and more than half declined admission, opting to self-isolate at home instead. Psychosocial home care support group sessions and discharge support groups held. Liaison with all other thematic pillars of the response was key. Conclusion: A comprehensive multidisciplinary mental health and psychosocial support service is an integral part of the management strategy during the pandemic response. The Psychosocial support by the Lagos Covid-19 response presents a practical reproducible approach.