Search

Your search keyword '"O'Kane A"' showing total 3,045 results
Start Over Author "O'Kane A" Language undetermined
3,045 results on '"O'Kane A"'

3. Explanation before Adoption: Supporting Informed Consent for Complex Machine Learning and IoT Health Platforms

Author

Rachel Eardley, Emma L. Tonkin, Ewan Soubutts, Amid Ayobi, Gregory J. L. Tourte, Rachael Gooberman-Hill, Ian Craddock, and Aisling Ann O'Kane

Subjects
Human-Computer Interaction, Computer Networks and Communications, Social Sciences (miscellaneous)
Abstract

Explaining health technology platforms to non-technical members of the public is an important part of the process of informed consent. Complex technology platforms that deal with safety-critical areas are particularly challenging, often operating within private domains (e.g. health services within the home) and used by individuals with various understandings of hardware, software, and algorithmic design. Through two studies, the first an interview and the second an observational study, we questioned how experts (e.g. those who designed, built, and installed a technology platform) supported provision of informed consent by participants. We identify a wide range of tools, techniques, and adaptations used by experts to explain the complex SPHERE sensor-based home health platform, provide implications for the design of tools to aid explanations, suggest opportunities for interactive explanations, present the range of information needed, and indicate future research possibilities in communicating technology platforms.

Published
2023
Full Text
View/download PDF

4. A palliative nursing strategy to enhance communication and support for patients and families in intensive care units

Author

Marie O'Kane, Kevin Gormley, and Jolly Isaac

Subjects
Advanced and Specialized Nursing
Abstract

Aim: There have been significant advancements in palliative nursing in health services, but less so in intensive care units (ICUs). The purpose of this literature review was to examine palliative nursing care in ICUs and consider how a nursing strategy could improve communication and support for patients and their families. Method: An exploratory literature review was conducted to evaluate and compare ICU care strategies with palliative support. The search was conducted using CINAHL Plus and Medline All databases and was limited to a 6-year period. Eight publications were selected for review and a full text review was undertaken using the Critical Appraisal Skills Programme systematic review checklist. Results: Two themes emerged around the use of palliative nursing strategies. These were: improving communication between health professionals and patients; and providing support for patients and families. Conclusions: Palliative nursing has the potential to improve the quality of communication in ICU settings and support for patients and families. Further training and preparation of nurses in palliative care would improve the patient and family experience during a critical and emotional period of health service provision.

Published
2023
Full Text
View/download PDF

7. Poor timing and failure of source control are risk factors for mortality in critically ill patients with secondary peritonitis

Author

De Pascale, Gennaro, Antonelli, Massimo, Deschepper, Mieke, Arvaniti, Kostoula, Blot, Koen, Brown, Ben Creagh, de Lange, Dylan, De Waele, Jan, Dikmen, Yalim, Dimopoulos, George, Eckmann, Christian, Francois, Guy, Girardis, Massimo, Koulenti, Despoina, Labeau, Sonia, Lipman, Jeffrey, Lipovetsky, Fernando, Maseda, Emilio, Montravers, Philippe, Mikstacki, Adam, Paiva, José-Artur, Pereyra, Cecilia, Rello, Jordi, Timsit, Jean-Francois, Vogelaers, Dirk, Blot, Stijn, Lamrous, Amin, Lipovestky, Fernando, Rezende-Neto, Joao, Vymazal, Tomas, Fjeldsoee-Nielsen, Hans, Kott, Matthias, Kostoula, Arvaniti, Javeri, Yash, Einav, Sharon, Makikado, Luis Daniel Umezawa, Tomescu, Dana, Gritsan, Alexey, Jovanovic, Bojan, Venkatesan, Kumaresh, Mirkovic, Tomislav, Creagh-Brown, Benedict, Emmerich, Monica, Canale, Mariana, Dietz, Lorena Silvina, Ilutovich, Santiago, Miñope, John Thomas Sanchez, Silva, Ramona Baldomera, Montenegro, Martin Alexis, Martin, Patricio, Saul, Pablo, Chediack, Viviana, Sutton, Giselle, Couce, Rocio, Balasini, Carina, Gonzalez, Susana, Lascar, Florencia Maria, Descotte, Emiliano Jorge, Gumiela, Natalia Soledad, Pino, Carina Alejandra, Cesio, Cristian, Valgolio, Emanuel, Cunto, Eleonora, Dominguez, Cecilia, Nelson, Nydia Funes, Abegao, Esteban Martin, Pozo, Norberto Christian, Bianchi, Luciana, Correger, Enrique, Pastorino, Maria Laura, Miyazaki, Erica Aurora, Grubissich, Nicolas, Garcia, Mariel, Bonetto, Natalia, Quevedo, Noelia Elizabeth, Gomez, Cristina Delia, Queti, Felipe, Estevarena, Luis Gonzalez, Fernandez, Ruben, Santolaya, Ignacio, Grangeat, Sergio Hugo, Doglia, Juan, Zakalik, Graciela, Pellegrini, Carlos, Lloria, Maria Monserrat, Chacon, Mercedes Esteban, Fumale, Mariela, Leguizamon, Mariela, Hidalgo, Irene Beatriz, Tiranti, Roberto Juli an, Capponi, Paola, Tita, Agustin, Cardonnet, Luis, Bettini, Lisandro, Ramos, Agñel, Lovesio, Luciano, Miranda, Edith Miriam, Farfan, Angelica Beatriz, Tolosa, Carina, Segura, Lise, Bellocchio, Adelina, Alvarez, Brian, Manzur, Adriana, Lujan, Rodolfo, Fernandez, Natalia, Scarone, Nahuel, Zazu, Alan, Groh, Carina, Fletcher, Jason, Smith, Julie, Azad, Raman, Chavan, Nitin, Kol, Mark, Campbell, Lewis, Starr, Therese, Roberts, Brigit, Wibrow, Bradley, Warhurst, Timothy, Chinthamuneedi, Meher, Ferney, Bernal Buitrago, Simon, Marc, De Backer, Daniel, Wittebole, Xavier, De Bels, David, Collin, Vincent, Dams, Karolien, Jorens, Philippe, Dubois, Jasperina, Gunst, Jan, Haentjens, Lionel, De Schryver, Nicolas, Dugernier, Thierry, Rizoli, Sandro, Santillan, Paul, Han, Yi, Biskup, Ewelina, Qu, Changjing, Li, Xinyu, Yu, Tao, Weihua, Lu, Molano-Franco, Daniel, Rojas, José, Oviedo, Juan Mauricio Pardo, Pinilla, Dario, Cardenas, Yenny, Celis, Edgar, Arias, Mario, Vukovic, Anita, Vudrag, Maja, Belavic, Matija, Zunic, Josip, Kuharic, Janja, Kricka, Irena Bozanic, Filipovic-Grcic, Ina, Tomasevic, Boris, Obraz, Melanija, Bodulica, Bruna, Dohnal, Martin, Malaska, Jan, Kratochvil, Milan, Satinsky, Igor, Schwarz, Peter, Kos, Zdenek, Blahut, Ladislav, Maca, Jan, Protus, Marek, Kieslichová, Eva, Nielsen, Louise Gramstrup, Krogh, Birgitte Marianne, Rivadeneira, Francisco, Morales, Freddy, Mora, José, Orozco, Alexandra Saraguro, MorochoTutillo, Diego Rolando, Vargas, Nelson Remache, Yepez, Estuardo Salgado, Villamagua, Boris, Alsisi, Adel, Fahmy, Abdelraouf, Dupont, Hervé, Lasocki, Sigismond, Paugam-Burtz, Catherine, Foucrier, Arnaud, Nica, Alexandru, Barjon, Geneviève, Mallat, Jihad, Marcotte, Guillaume, Leone, Marc, Duclos, Gary, Burtin, Philippe, Atchade, Enora, Mahjoub, Yazine, Misset, Benoît, Timsit, Jean-François, Dupuis, Claire, Veber, Benoît, Debarre, Matthieu, Collange, Oliver, Pottecher, Julien, Hecketsweiler, Stephane, Fromentin, Mélanie, Tesnière, Antoine, Koch, Christian, Sander, Michael, Elke, Gunnar, Wrigge, Hermann, Simon, Philipp, Chalkiadaki, Anthoula, Tzanidakis, Charalampos, Pneumatikos, Ioannis, Sertaridou, Eleni, Mastora, Zafiria, Pantazopoulos, Ioannis, Papanikolaou, Metaxia, Papavasilopoulou, Theonymfi, Floros, John, Diakaki, Chryssa, Rallis, Michael, Paridou, Alexandra, Kalogeromitros, Alexandros, Romanou, Vasiliki, Nikolaou, Charikleia, Kounougeri, Katerina, Tsigou, Evdoxia, Psallida, Vasiliki, Karampela, Niki, Mandragos, Konstantinos, Kontoudaki, Eftychia, Pentheroudaki, Alexandra, Farazi-Chongouki, Christos, Karakosta, Agathi, Chouris, Isaac, Radu, Vasiliki, Malliotakis, Polychronis, Kokkini, Sofia, Charalambous, Eliana, Kyritsi, Aikaterini, Koulouras, Vasilios, Papathanakos, Georgios, Nagky, Eva, Lampiri, Clairi, Tsimpoukas, Fotios, Sarakatsanos, Ioannis, Georgakopoulos, Panagiotis, Ravani, Ifigeneia, Prekates, Athanasios, Sakellaridis, Konstantinos, Christopoulos, Christos, Vrettou, Efstratia, Stokkos, Konstantinos, Pentari, Anastasia, Marmanidou, Kyriaki, Kydona, Christina, Tsoumaropoulos, Georgios, Bitzani, Militisa, Kontou, Paschalina, Voudouris, Antonios, Flioni, Elli-Nikki, Antypa, Elli, Chasou, Eleftheria, Anisoglou, Souzana, Papageorgiou, Eirini, Paraforou, Theoniki, Tsioka, Agoritsa, Karathanou, Antigoni, Vakalos, Aristeidis, Shah, Bhagyesh, Thakkar, Chirag, Jain, Nikhilesh, Gurjar, Mohan, Baronia, Arvind, Sathe, Prachee, Kulkarni, Shilpa, Paul, Cherish, Paul, John, Masjedi, Mansoor, Nikandish, Reza, Zand, Farid, Sabetian, Golnar, Mahmoodpoor, Ata, Hashemian, Seyed Mohammadreza, Bala, Miklosh, Flocco, Romeo, Torrente, Sergio, Pota, Vincenzo, Spadaro, Savino, Volta, Carlo, Serafini, Giulia, Boraso, Sabrina, Tiberio, Ivo, Cortegiani, Andrea, Misseri, Giovanni, Barbagallo, Maria, Nicolotti, Davide, Forfori, Francesco, Corradi, Francesco, Pelagalli, Lorella, Brazzi, Luca, Vittone, Ferdinando Giorgio, Russo, Alessandro, Simion, Davide, Cotoia, Antonella, Toppin, Gilda Cinnella Patrick, Johnson-Jackson, Roxanne, Hayashi, Yoshiro, Yamamoto, Ryohei, Yasuda, Hideto, Kishihara, Yuki, Shiotsuka, Junji, Sanchez-Hurtado, Luis Alejandro, Tejeda-Huezo, Brigitte, Gorordo, Luis, Ñamendys-Silva, Silvio A, Garcia-Guillen, Francisco J, Martinez, Manuel, Romero-Meja, Erick, Colorado-Dominguez, Ever, van den Oever, Huub, Kalff, Karel Martijn, Vermeijden, Wytze, Cornet, Alexander Daniel, Beck, Oliver, Cimic, Nedim, Dormans, Tom, Bormans, Laura, Bakker, Jan, Van Duijn, Ditty, Bosman, Gerrit, Vos, Piet, Kesecioglu, Jozef, Haas, Lenneke, Henein, Akram, Miranda, Ariel M, Malca, Gonzalo Ernesto Gianella, Arroyo-Sanchez, Abel, Misiewska-Kaczur, Agnieszka, Akinyi, Frisch, Czuczwar, Miroslaw, Luczak, Karolina, Sulkowski, Wiktor, Tamowicz, Barbara, Swit, Beata, Baranowski, Bronisław, Smuszkiewicz, Piotr, Trojanowska, Iwona, Rzymski, Stanislaw, Sawinski, Mariusz, Trosiak, Marta, Mikaszewska-Sokolewicz, Malgorzata, Alves, Ricardo, Leal, Dina, Krystopchuk, Andriy, Mendonca, Pedro Muguel Hilario, Pereira, Rui Antunes, de Carvalho, Maria Raquel Lopes Marques, Candeias, Carlos, Molinos, Elena, Ferreira, Amélia, Castro, Guiomar, Pereira, José-Manuel, Santos, Lurdes, Ferreira, Alcina, Pascoalinho, Dulce, Ribeiro, Rosa, Domingos, Guilherme, Gomes, Pedro, Nora, David, Costa, Rui Pedro, Santos, Anabela, Alsheikhly, Ahmed Subhy, Popescu, Mihai, Grigoras, Ioana, Patrascanu, Emilia, Zabolotskikh, Igor, Musaeva, Tatiana, Gaigolnik, Denis, Kulabukhov, Vladimir, Belskiy, Vladislav, Zubareva, Nadezhda, Tribulev, Maxim, Abdelsalam, Ahmed, Aldarsani, Ayman, Al-Khalid, Muhammad, Almekhlafi, Ghaleb, Mandourah, Yasser, Doklestic, Krstina, Velickovic, Jelena, Velickovic, Dejan, Jankovic, Radmilo, Skoric-Jokic, Svetlana, Radovanovic, Dragana, Richards, Guy, Alli, Ahmad, Cordoba Nielfa, del Carmen, Iniesta, Rafael Sánchez, Martínez, Adela Benítez-Cano, Bernedo, Carlos Garcia, Gil, Santiago Alberto Picos, Nuvials, Xavier, Garcia, Joseba Gonzalez, Peña, Jose Manuel Garcia, Jimenez, Roberto, Herrera, Luis, Barrachina, Laura Galarza, Monzon, Ignacio Catalan, Redondo, Francisco Javier, Villazala, Ruben, Zapata, Diego Fernando Matallana, Lopez, Isabel Maria Villa, Moreno-Gonzalez, Gabriel, Lopez-Delgado, Juan Carlos, Marin, Jorge Solera, Sanchez-Zamora, Purificacion, Vidal, Montserrat Vallverdú, González, Jesús Flores, Salinas, Irene, Hermosa, Cecilia, Martinez-Sagasti, Fernando, Domingo-Marín, Sara, Victorino, Johanna Abril, Garcia-Alvarez, Raquel, Calleja, Pablo López-Arcas, de la Torre-Prados, Maria Victoria, Vidal-Cortes, Pablo, del Río-Carbajo, Lorena, Izura, Javier, Minguez, Victoria, Alvarez, Josep Trenado, Prous, Anna Parera, Paz, Daniel, Roche-Campo, Ferran, Aguilar, Gerardo, Belda, Javier, Rico-Feijoo, Jesus, Aldecoa, Cesat, Zalba-Etayo, Begoña, Dullenkopf, Alexander, Trongtrakul, Konlawij, Chtsomkasem, Anusang, Akbaş, Türkay, Unal, Mustafa Necmettin, Gumus, Ayca, Ramazanoglu, Atilla, Memis, Dilek, Mehmet, Inal, Urkmez, Seval, Ozgultekin, Asu, Demirkiran, Oktay, Aslan, Nesrin Ahu, Kizilaslan, Deniz, Kahveci, Ferda, Ünlü, Nurdan, Ozkan, Zeynep, Kaye, Callum, Jansen, Jan, O’Neill, Orla, Nutt, Christopher, Jha, Rajeev, Hooker, Nicolas, Grecu, Irina, Petridou, Christina, Shyamsundar, Murali, McNamee, Lia, Trinder, John, Hagan, Samantha, Kelly, Catriona, Silversides, Jonathon, Groba, Casiano Barrera, Boyd, Owen, Bhowmick, Kaushik, Humphreys, Sally, Summers, Charlotte, Polgarova, Petra, Margarson, Michael, Dickens, Justin, Pearson, Suzanne, Chinery, Elaine, Hemmings, Noel, O’Kane, Sinead, Austin, Pauline, Cole, Stephen, Plowright, Catherine, Box, Roberta, Wright, Christopher, Young, Lorna, Creagh-Brown, Ben, Montague, Laura, Parker, Robert, Morton, Ben, Ostermann, Marlies, Bilinska, Julia, Rose, Bernd Oliver, Reece-Anthony, Rosie, Ryan, Christine, Hamilton, Mark, Hopkins, Philip, Wendon, Julia, Brescia, Giovanni, Ijaz, Nazia, Wood, James, George, Michelle, Toth-Tarsoly, Piroska, Yates, Bryan, Armstrong, Maureen, Scott, Carmen, Boyd, Christine, Szakmany, Tamas, Rees, David, Pulak, Paul, Coggon, Mandy, Saha, Bhaskar, Kent, Linda, Gibson, Bethan, Camsooksai, Julie, Reschreiter, Henrik, Morgan, Pat, Sangaralingham, Sivatharshini, Lowe, Alastair, Vondras, Petr, Jamadarkhana, Sunil, Cruz, Carina, Bhandary, Rakesh, Hersey, Peter, Furneval, Julie, Innes, Richard, Doble, Patricia, Attwood, Ben, Parsons, Penny, Page, Valerie, Zhao, Xiaobei, Dalton, Julian, Hegazy, Mohammed, Awad, Yasser, Naylor, Douglas, Naylor, Amanda, Lee, Sarah, Brevard, Sidney, Davis, Noelle, De Pascale, Gennaro, Antonelli, Massimo, Deschepper, Mieke, Arvaniti, Kostoula, Blot, Koen, Brown, Ben Creagh, de Lange, Dylan, De Waele, Jan, Dikmen, Yalim, Dimopoulos, George, Eckmann, Christian, Francois, Guy, Girardis, Massimo, Koulenti, Despoina, Labeau, Sonia, Lipman, Jeffrey, Lipovetsky, Fernando, Maseda, Emilio, Montravers, Philippe, Mikstacki, Adam, Paiva, José-Artur, Pereyra, Cecilia, Rello, Jordi, Timsit, Jean-Francoi, Vogelaers, Dirk, Blot, Stijn, Lamrous, Amin, Lipovestky, Fernando, Rezende-Neto, Joao, Vymazal, Toma, Fjeldsoee-Nielsen, Han, Kott, Matthia, Kostoula, Arvaniti, Javeri, Yash, Einav, Sharon, Makikado, Luis Daniel Umezawa, Tomescu, Dana, Gritsan, Alexey, Jovanovic, Bojan, Venkatesan, Kumaresh, Mirkovic, Tomislav, Creagh-Brown, Benedict, Emmerich, Monica, Canale, Mariana, Dietz, Lorena Silvina, Ilutovich, Santiago, Miñope, John Thomas Sanchez, Silva, Ramona Baldomera, Montenegro, Martin Alexi, Martin, Patricio, Saul, Pablo, Chediack, Viviana, Sutton, Giselle, Couce, Rocio, Balasini, Carina, Gonzalez, Susana, Lascar, Florencia Maria, Descotte, Emiliano Jorge, Gumiela, Natalia Soledad, Pino, Carina Alejandra, Cesio, Cristian, Valgolio, Emanuel, Cunto, Eleonora, Dominguez, Cecilia, Nelson, Nydia Fune, Abegao, Esteban Martin, Pozo, Norberto Christian, Bianchi, Luciana, Correger, Enrique, Pastorino, Maria Laura, Miyazaki, Erica Aurora, Grubissich, Nicola, Garcia, Mariel, Bonetto, Natalia, Quevedo, Noelia Elizabeth, Gomez, Cristina Delia, Queti, Felipe, Estevarena, Luis Gonzalez, Fernandez, Ruben, Santolaya, Ignacio, Grangeat, Sergio Hugo, Doglia, Juan, Zakalik, Graciela, Pellegrini, Carlo, Lloria, Maria Monserrat, Chacon, Mercedes Esteban, Fumale, Mariela, Leguizamon, Mariela, Hidalgo, Irene Beatriz, Tiranti, Roberto Juli an, Capponi, Paola, Tita, Agustin, Cardonnet, Lui, Bettini, Lisandro, Ramos, Agñel, Lovesio, Luciano, Miranda, Edith Miriam, Farfan, Angelica Beatriz, Tolosa, Carina, Segura, Lise, Bellocchio, Adelina, Alvarez, Brian, Manzur, Adriana, Lujan, Rodolfo, Fernandez, Natalia, Scarone, Nahuel, Zazu, Alan, Groh, Carina, Fletcher, Jason, Smith, Julie, Azad, Raman, Chavan, Nitin, Kol, Mark, Campbell, Lewi, Starr, Therese, Roberts, Brigit, Wibrow, Bradley, Warhurst, Timothy, Chinthamuneedi, Meher, Ferney, Bernal Buitrago, Simon, Marc, De Backer, Daniel, Wittebole, Xavier, De Bels, David, Collin, Vincent, Dams, Karolien, Jorens, Philippe, Dubois, Jasperina, Gunst, Jan, Haentjens, Lionel, De Schryver, Nicola, Dugernier, Thierry, Rizoli, Sandro, Santillan, Paul, Han, Yi, Biskup, Ewelina, Qu, Changjing, Li, Xinyu, Yu, Tao, Weihua, Lu, Molano-Franco, Daniel, Rojas, José, Oviedo, Juan Mauricio Pardo, Pinilla, Dario, Cardenas, Yenny, Celis, Edgar, Arias, Mario, Vukovic, Anita, Vudrag, Maja, Belavic, Matija, Zunic, Josip, Kuharic, Janja, Kricka, Irena Bozanic, Filipovic-Grcic, Ina, Tomasevic, Bori, Obraz, Melanija, Bodulica, Bruna, Dohnal, Martin, Malaska, Jan, Kratochvil, Milan, Satinsky, Igor, Schwarz, Peter, Kos, Zdenek, Blahut, Ladislav, Maca, Jan, Protus, Marek, Kieslichová, Eva, Nielsen, Louise Gramstrup, Krogh, Birgitte Marianne, Rivadeneira, Francisco, Morales, Freddy, Mora, José, Orozco, Alexandra Saraguro, MorochoTutillo, Diego Rolando, Vargas, Nelson Remache, Yepez, Estuardo Salgado, Villamagua, Bori, Alsisi, Adel, Fahmy, Abdelraouf, Dupont, Hervé, Lasocki, Sigismond, Paugam-Burtz, Catherine, Foucrier, Arnaud, Nica, Alexandru, Barjon, Geneviève, Mallat, Jihad, Marcotte, Guillaume, Leone, Marc, Duclos, Gary, Burtin, Philippe, Atchade, Enora, Mahjoub, Yazine, Misset, Benoît, Timsit, Jean-Françoi, Dupuis, Claire, Veber, Benoît, Debarre, Matthieu, Collange, Oliver, Pottecher, Julien, Hecketsweiler, Stephane, Fromentin, Mélanie, Tesnière, Antoine, Koch, Christian, Sander, Michael, Elke, Gunnar, Wrigge, Hermann, Simon, Philipp, Chalkiadaki, Anthoula, Tzanidakis, Charalampo, Pneumatikos, Ioanni, Sertaridou, Eleni, Mastora, Zafiria, Pantazopoulos, Ioanni, Papanikolaou, Metaxia, Papavasilopoulou, Theonymfi, Floros, John, Diakaki, Chryssa, Rallis, Michael, Paridou, Alexandra, Kalogeromitros, Alexandro, Romanou, Vasiliki, Nikolaou, Charikleia, Kounougeri, Katerina, Tsigou, Evdoxia, Psallida, Vasiliki, Karampela, Niki, Mandragos, Konstantino, Kontoudaki, Eftychia, Pentheroudaki, Alexandra, Farazi-Chongouki, Christo, Karakosta, Agathi, Chouris, Isaac, Radu, Vasiliki, Malliotakis, Polychroni, Kokkini, Sofia, Charalambous, Eliana, Kyritsi, Aikaterini, Koulouras, Vasilio, Papathanakos, Georgio, Nagky, Eva, Lampiri, Clairi, Tsimpoukas, Fotio, Sarakatsanos, Ioanni, Georgakopoulos, Panagioti, Ravani, Ifigeneia, Prekates, Athanasio, Sakellaridis, Konstantino, Christopoulos, Christo, Vrettou, Efstratia, Stokkos, Konstantino, Pentari, Anastasia, Marmanidou, Kyriaki, Kydona, Christina, Tsoumaropoulos, Georgio, Bitzani, Militisa, Kontou, Paschalina, Voudouris, Antonio, Flioni, Elli-Nikki, Antypa, Elli, Chasou, Eleftheria, Anisoglou, Souzana, Papageorgiou, Eirini, Paraforou, Theoniki, Tsioka, Agoritsa, Karathanou, Antigoni, Vakalos, Aristeidi, Shah, Bhagyesh, Thakkar, Chirag, Jain, Nikhilesh, Gurjar, Mohan, Baronia, Arvind, Sathe, Prachee, Kulkarni, Shilpa, Paul, Cherish, Paul, John, Masjedi, Mansoor, Nikandish, Reza, Zand, Farid, Sabetian, Golnar, Mahmoodpoor, Ata, Hashemian, Seyed Mohammadreza, Bala, Miklosh, Flocco, Romeo, Torrente, Sergio, Pota, Vincenzo, Spadaro, Savino, Volta, Carlo, Serafini, Giulia, Boraso, Sabrina, Tiberio, Ivo, Cortegiani, Andrea, Misseri, Giovanni, Barbagallo, Maria, Nicolotti, Davide, Forfori, Francesco, Corradi, Francesco, Pelagalli, Lorella, Brazzi, Luca, Vittone, Ferdinando Giorgio, Russo, Alessandro, Simion, Davide, Cotoia, Antonella, Toppin, Gilda Cinnella Patrick, Johnson-Jackson, Roxanne, Hayashi, Yoshiro, Yamamoto, Ryohei, Yasuda, Hideto, Kishihara, Yuki, Shiotsuka, Junji, Sanchez-Hurtado, Luis Alejandro, Tejeda-Huezo, Brigitte, Gorordo, Lui, Ñamendys-Silva, Silvio A, Garcia-Guillen, Francisco J, Martinez, Manuel, Romero-Meja, Erick, Colorado-Dominguez, Ever, van den Oever, Huub, Kalff, Karel Martijn, Vermeijden, Wytze, Cornet, Alexander Daniel, Beck, Oliver, Cimic, Nedim, Dormans, Tom, Bormans, Laura, Bakker, Jan, Van Duijn, Ditty, Bosman, Gerrit, Vos, Piet, Kesecioglu, Jozef, Haas, Lenneke, Henein, Akram, Miranda, Ariel M, Malca, Gonzalo Ernesto Gianella, Arroyo-Sanchez, Abel, Misiewska-Kaczur, Agnieszka, Akinyi, Frisch, Czuczwar, Miroslaw, Luczak, Karolina, Sulkowski, Wiktor, Tamowicz, Barbara, Swit, Beata, Baranowski, Bronisław, Smuszkiewicz, Piotr, Trojanowska, Iwona, Rzymski, Stanislaw, Sawinski, Mariusz, Trosiak, Marta, Mikaszewska-Sokolewicz, Malgorzata, Alves, Ricardo, Leal, Dina, Krystopchuk, Andriy, Mendonca, Pedro Muguel Hilario, Pereira, Rui Antune, de Carvalho, Maria Raquel Lopes Marque, Candeias, Carlo, Molinos, Elena, Ferreira, Amélia, Castro, Guiomar, Pereira, José-Manuel, Santos, Lurde, Ferreira, Alcina, Pascoalinho, Dulce, Ribeiro, Rosa, Domingos, Guilherme, Gomes, Pedro, Nora, David, Costa, Rui Pedro, Santos, Anabela, Alsheikhly, Ahmed Subhy, Popescu, Mihai, Grigoras, Ioana, Patrascanu, Emilia, Zabolotskikh, Igor, Musaeva, Tatiana, Gaigolnik, Deni, Kulabukhov, Vladimir, Belskiy, Vladislav, Zubareva, Nadezhda, Tribulev, Maxim, Abdelsalam, Ahmed, Aldarsani, Ayman, Al-Khalid, Muhammad, Almekhlafi, Ghaleb, Mandourah, Yasser, Doklestic, Krstina, Velickovic, Jelena, Velickovic, Dejan, Jankovic, Radmilo, Skoric-Jokic, Svetlana, Radovanovic, Dragana, Richards, Guy, Alli, Ahmad, Cordoba Nielfa, del Carmen, Iniesta, Rafael Sánchez, Martínez, Adela Benítez-Cano, Bernedo, Carlos Garcia, Gil, Santiago Alberto Pico, Nuvials, Xavier, Garcia, Joseba Gonzalez, Peña, Jose Manuel Garcia, Jimenez, Roberto, Herrera, Lui, Barrachina, Laura Galarza, Monzon, Ignacio Catalan, Redondo, Francisco Javier, Villazala, Ruben, Zapata, Diego Fernando Matallana, Lopez, Isabel Maria Villa, Moreno-Gonzalez, Gabriel, Lopez-Delgado, Juan Carlo, Marin, Jorge Solera, Sanchez-Zamora, Purificacion, Vidal, Montserrat Vallverdú, González, Jesús Flore, Salinas, Irene, Hermosa, Cecilia, Martinez-Sagasti, Fernando, Domingo-Marín, Sara, Victorino, Johanna Abril, Garcia-Alvarez, Raquel, Calleja, Pablo López-Arca, de la Torre-Prados, Maria Victoria, Vidal-Cortes, Pablo, del Río-Carbajo, Lorena, Izura, Javier, Minguez, Victoria, Alvarez, Josep Trenado, Prous, Anna Parera, Paz, Daniel, Roche-Campo, Ferran, Aguilar, Gerardo, Belda, Javier, Rico-Feijoo, Jesu, Aldecoa, Cesat, Zalba-Etayo, Begoña, Dullenkopf, Alexander, Trongtrakul, Konlawij, Chtsomkasem, Anusang, Akbaş, Türkay, Unal, Mustafa Necmettin, Gumus, Ayca, Ramazanoglu, Atilla, Memis, Dilek, Mehmet, Inal, Urkmez, Seval, Ozgultekin, Asu, Demirkiran, Oktay, Aslan, Nesrin Ahu, Kizilaslan, Deniz, Kahveci, Ferda, Ünlü, Nurdan, Ozkan, Zeynep, Kaye, Callum, Jansen, Jan, O’Neill, Orla, Nutt, Christopher, Jha, Rajeev, Hooker, Nicola, Grecu, Irina, Petridou, Christina, Shyamsundar, Murali, McNamee, Lia, Trinder, John, Hagan, Samantha, Kelly, Catriona, Silversides, Jonathon, Groba, Casiano Barrera, Boyd, Owen, Bhowmick, Kaushik, Humphreys, Sally, Summers, Charlotte, Polgarova, Petra, Margarson, Michael, Dickens, Justin, Pearson, Suzanne, Chinery, Elaine, Hemmings, Noel, O’Kane, Sinead, Austin, Pauline, Cole, Stephen, Plowright, Catherine, Box, Roberta, Wright, Christopher, Young, Lorna, Creagh-Brown, Ben, Montague, Laura, Parker, Robert, Morton, Ben, Ostermann, Marlie, Bilinska, Julia, Rose, Bernd Oliver, Reece-Anthony, Rosie, Ryan, Christine, Hamilton, Mark, Hopkins, Philip, Wendon, Julia, Brescia, Giovanni, Ijaz, Nazia, Wood, Jame, George, Michelle, Toth-Tarsoly, Piroska, Yates, Bryan, Armstrong, Maureen, Scott, Carmen, Boyd, Christine, Szakmany, Tama, Rees, David, Pulak, Paul, Coggon, Mandy, Saha, Bhaskar, Kent, Linda, Gibson, Bethan, Camsooksai, Julie, Reschreiter, Henrik, Morgan, Pat, Sangaralingham, Sivatharshini, Lowe, Alastair, Vondras, Petr, Jamadarkhana, Sunil, Cruz, Carina, Bhandary, Rakesh, Hersey, Peter, Furneval, Julie, Innes, Richard, Doble, Patricia, Attwood, Ben, Parsons, Penny, Page, Valerie, Zhao, Xiaobei, Dalton, Julian, Hegazy, Mohammed, Awad, Yasser, Naylor, Dougla, Naylor, Amanda, Lee, Sarah, Brevard, Sidney, Davis, Noelle, Morochotutillo, Diego Rolando, Baranowski, Bronislaw, Akbas, Türkay, Mcnamee, Lia, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, and UCL - (SLuc) Service de soins intensifs

Subjects
Adult, Secondary peritoniti, Critical Illness, Peritonitis, Critical Care and Intensive Care Medicine, Anti-Bacterial Agents, Antimicrobial therapy, Intensive Care Units, Secondary peritonitis, Intra-abdominal infection, Anti-Infective Agents, Risk Factors, Source control, Sepsis, Medicine and Health Sciences, Humans, Intraabdominal Infections, Mortality, Retrospective Studies
Abstract

PURPOSE: To describe data on epidemiology, microbiology, clinical characteristics and outcome of adult patients admitted in the intensive care unit (ICU) with secondary peritonitis, with special emphasis on antimicrobial therapy and source control. METHODS: Post hoc analysis of a multicenter observational study (Abdominal Sepsis Study, AbSeS) including 2621 adult ICU patients with intra-abdominal infection in 306 ICUs from 42 countries. Time-till-source control intervention was calculated as from time of diagnosis and classified into 'emergency' (< 2 h), 'urgent' (2-6 h), and 'delayed' (> 6 h). Relationships were assessed by logistic regression analysis and reported as odds ratios (OR) and 95% confidence interval (CI). RESULTS: The cohort included 1077 cases of microbiologically confirmed secondary peritonitis. Mortality was 29.7%. The rate of appropriate empiric therapy showed no difference between survivors and non-survivors (66.4% vs. 61.3%, p = 0.1). A stepwise increase in mortality was observed with increasing Sequential Organ Failure Assessment (SOFA) scores (19.6% for a value ≤ 4-55.4% for a value > 12, p < 0.001). The highest odds of death were associated with septic shock (OR 3.08 [1.42-7.00]), late-onset hospital-acquired peritonitis (OR 1.71 [1.16-2.52]) and failed source control evidenced by persistent inflammation at day 7 (OR 5.71 [3.99-8.18]). Compared with 'emergency' source control intervention (< 2 h of diagnosis), 'urgent' source control was the only modifiable covariate associated with lower odds of mortality (OR 0.50 [0.34-0.73]). CONCLUSION: 'Urgent' and successful source control was associated with improved odds of survival. Appropriateness of empirical antimicrobial treatment did not significantly affect survival suggesting that source control is more determinative for outcome. TRIAL REGISTRATION: ClinicalTrials.gov NCT03270345.

Published
2022
Full Text
View/download PDF

8. The geometry of active shortening in the northwest Himalayas and the implications for seismic hazard

Author

O'kane, A, Copley, A, Mitra, S, Wimpenny, S, O'kane, A [0000-0001-7429-9103], Copley, A [0000-0003-0362-0494], Wimpenny, S [0000-0002-2937-7501], and Apollo - University of Cambridge Repository

Subjects
Computational seismology, Folds and folding, Geophysics, Geochemistry and Petrology, Geomorphology, Earthquake hazards, Earthquake ground motions, Seismicity and tectonics
Abstract

SUMMARYLarge thrust faults accommodate the convergence between India and Tibet along the southern margin of the Himalaya and have a history of producing great earthquakes that cause widespread damage. Along most parts of the Himalaya, there is geomorphological evidence that these thrusts can rupture to the surface in Mw >8 earthquakes. However, in the Himalayan state of Jammu & Kashmir (NW India), the thrust faults are blind and large-scale folding is the only expression of active deformation at the surface, making it difficult to assess the seismic hazard in this region. In this paper, we use field, satellite, and seismological observations to determine the fault geometry in Jammu & Kashmir. We then estimate the ground motions from potential earthquakes in the region using models of the seismic wavefield that would be generated if the thrust fault beneath Jammu & Kashmir were to rupture. We find that earthquakes that rupture the buried, shallow part of the locked Main Himalayan Thrust could generate peak ground velocities that are >3 times larger than earthquakes of the same magnitude on its deeper portions. We also model the ground motions that would result from the thrust fault geometries representative of different parts of the Himalayan arc. These simulations show that even seemingly minor variations in the shallow fault geometry can lead to large differences in the expected ground motions, highlighting the importance of accurately determining the shallow geometry of thrust faults along the margins of mountain ranges for estimating seismic hazard.

Published
2022
Full Text
View/download PDF

9. Systemic inflammatory prognostic scores in advanced pancreatic adenocarcinoma

Author

Lucy X. Ma, Yifan Wang, Osvaldo Espin-Garcia, Michael J. Allen, Gun Ho Jang, Amy Zhang, Anna Dodd, Stephanie Ramotar, Shawn Hutchinson, Mustapha Tehfe, Ravi Ramjeesingh, James Biagi, Julie M. Wilson, Faiyaz Notta, Sandra E. Fischer, George Zogopoulos, Steven Gallinger, Robert C. Grant, Rama Khokha, Nathan Chan, Barbara T. Grünwald, Jennifer J. Knox, and Grainne M. O’Kane

Subjects
Cancer Research, Oncology
Published
2023
Full Text
View/download PDF

10. Ocean Model Response to Stochastically Perturbed Momentum Fluxes

Author

Terence J. O’Kane, Russell Fiedler, Mark A. Collier, and Vassili Kitsios

Subjects
Atmospheric Science, Physics::Atmospheric and Oceanic Physics
Abstract

In climate model configurations, standard approaches to the representation of unresolved, or subgrid scales, via deterministic closure schemes are being challenged by stochastic approaches inspired by statistical dynamical theory. Despite gaining popularity, studies of various stochastic subgrid scale parameterizations applied to atmospheric climate and weather prediction systems have revealed a diversity of model responses, including degeneracy in the response to different forcings and compensating model errors, with little reduction in artificial damping of the small scales required for numerical stability. Due to the greater range of spatio-temporal scales involved, how to best sample subgrid fluctuations in a computationally inexpensive manner, with the aim of reduced model error and improvements to the simulated climatological state of the ocean, remains an open question. While previous studies have considered perturbations to the surface forcing or subsurface temperature tendencies, we implement an energetically consistent, simple, stochastic subgrid eddy parameterization of the momentum fluxes in regions of the three-dimensional ocean typically associated with high eddy variability. We consider the changes in the modelled energetics of low-resolution simulations in response to stochastically forced velocity tendencies whose perturbation statistics and amplitudes are calculated from an eddy resolving ocean configuration. Kinetic energy spectra from a triple-decomposition reveal a systematic redistribution from the seasonal (climatological minus mean) potential energy to preferentially generate small scale transient kinetic energy while the total energy spectra remains largely unchanged. We show that stochastic parameterization generally improves model biases, noticeably so for the simulated energetics of the Southern Oceans.

Published
2023
Full Text
View/download PDF

11. Understanding New Zealand firm innovation: exploring human resource factors by firm size and strength

Author

Jarrod Haar and Conor O’Kane

Subjects
Multidisciplinary
Abstract

Firm innovation is of vital importance to New Zealand’s economy, but we understand little about how different human resource (workforce) factors influence innovation approaches (product/services innovation, process innovation, and innovation speed). We explore three human resource (HR) factors: workforce knowledge, skills, and abilities (KSAs), workforce attraction, and workforce retention, using a sample of New Zealand private sector firms (n = 402). Regression analysis shows all HR factors are significant predictors of all innovation approaches. Further analysis shows workforce KSAs is dominant towards product/service innovation, workforce attraction is dominant towards process innovation, and workforce retention is dominant towards innovation speed. Moderating effects by firm size are found showing small-sized firms out innovate large-sized firms when workforce KSA are high, despite small-sized firms having, on average, weaker HR factors and innovation approaches than large-sized firms. We highlight the organisational implications across small – and large-sized firms.

Published
2023
Full Text
View/download PDF

12. The First Modified Delphi Consensus-Building Exercise on Surgical Ward Rounds in the United Kingdom National Health Service

Author

Bassem Amr, Islam Omar, Mohamed Abdelrahman, Muhammad Abdalkoddus, Yasmin Abou El Ella, Mohamed Abouelazayem, Mohammed O. A. Abubakr, Sian Andrews, Sherif Awad, David Bunting, Lindes Callejas-Diaz, William A. Cambridge, William Carr, Angela Chesworth, Michael J. Courtney, Jemma edge, Farid Froghi, Andrew Gilliam, Yitka graham, Sarah Harwood, Marianne Hollyman, Adam Kimble, Ahmed kotb, Ridhi Majithia, Sue Mallinson, Nicky Metcalfe, Mary O’Kane, Chetan Parmar, Saniya Saiyed, Mohamed Shaban, Rishi Singhal, Lisa Trewin, Himanshu Wadhawan, and Kamal Mahawar

Subjects
Surgery
Published
2023
Full Text
View/download PDF

14. International Forum on Transfusion Education for Healthcare Professionals Who Administer Blood to Patients in Hospitals and Health Services: Summary

Author

Arwa Z. Al‐Riyami, Linley Bielby, Rachel Moss, Naomi Rahimi‐Levene, Aine O'Kane, John R. Hess, Noor e Saba, Kyeong‐Hee Kim, Satyam Arora, Seema Dua, Claire L. Barrett, Carlos A. Gonzalez, David Martin Ferrari, Paula V. Cini, Midori Kumagawa, Claire O'Reilly, Liz Thrift, Silvano Wendel, Roberta Fachini, Lara Faria Souza Dias, Dung Tran, Christine T. Steinsvåg, and Nancy Dunbar

Subjects
Hematology, General Medicine
Published
2023
Full Text
View/download PDF

15. International Forum on Transfusion Education for Healthcare Professionals Who Administer Blood to Patients in Hospitals and Health Services: Responses

Author

Arwa Z. Al‐Riyami, Linley Bielby, Rachel Moss, Naomi Rahimi‐Levene, Aine O'Kane, John R. Hess, Noor e Saba, Kyeong‐Hee Kim, Satyam Arora, Seema Dua, Claire L. Barrett, Carlos A. Gonzalez, David Martin Ferrari, Paula V. Cini, Midori Kumagawa, Claire O'Reilly, Liz Thrift, Silvano Wendel, Roberta Fachini, Lara Faria Souza Dias, Dung Tran, Christine T. Steinsvåg, and Nancy Dunbar

Subjects
Hematology, General Medicine
Published
2023
Full Text
View/download PDF

17. Randomized comparison of chest pain evaluation with FFRCT or standard care: Factors determining US costs

Author

Mark A. Hlatky, Sam Wilding, Beth Stuart, Zoe Nicholas, James Shambrook, Zina Eminton, Kim Fox, Derek Connolly, Peter O'Kane, Alex Hobson, Anoop Chauhan, Neal Uren, Gerry P. Mccann, Colin Berry, Justin Carter, Carl Roobottom, Mamas Mamas, Ronak Rajani, Ian Ford, Pamela S. Douglas, and Nick Curzen

Subjects
Radiology, Nuclear Medicine and imaging, Cardiology and Cardiovascular Medicine
Published
2023
Full Text
View/download PDF

18. Drosophila SPG12 ortholog, reticulon-like 1, governs presynaptic ER organization and Ca2+ dynamics

Author

Pérez-Moreno, Juan José, Smith, Rebecca C, Oliva, Megan K, Gallo, Filomena, Ojha, Shainy, Müller, Karin H, O'Kane, Cahir J, Pérez-Moreno, Juan José [0000-0002-8497-3066], Smith, Rebecca C [0000-0001-8418-481X], Oliva, Megan K [0000-0003-0101-8985], Gallo, Filomena [0000-0002-8921-9919], Ojha, Shainy [0000-0002-5079-9928], Müller, Karin H [0000-0003-4693-8558], O'Kane, Cahir J [0000-0002-3488-2078], and Apollo - University of Cambridge Repository

Subjects
Spastic Paraplegia, Hereditary, Animals, Humans, Drosophila Proteins, Membrane Proteins, Calcium, Drosophila, Endoplasmic Reticulum
Abstract

Neuronal endoplasmic reticulum (ER) appears continuous throughout the cell. Its shape and continuity are influenced by ER-shaping proteins, mutations in which can cause distal axon degeneration in Hereditary Spastic Paraplegia (HSP). We therefore asked how loss of Rtnl1, a Drosophila ortholog of the human HSP gene RTN2 (SPG12), which encodes an ER-shaping protein, affects ER organization and the function of presynaptic terminals. Loss of Rtnl1 depleted ER membrane markers at Drosophila presynaptic motor terminals and appeared to deplete narrow tubular ER while leaving cisternae largely unaffected, thus suggesting little change in resting Ca2+ storage capacity. Nevertheless, these changes were accompanied by major reductions in activity-evoked Ca2+ fluxes in the cytosol, ER lumen, and mitochondria, as well as reduced evoked and spontaneous neurotransmission. We found that reduced STIM-mediated ER-plasma membrane contacts underlie presynaptic Ca2+ defects in Rtnl1 mutants. Our results show the importance of ER architecture in presynaptic physiology and function, which are therefore potential factors in the pathology of HSP.

Published
2023

19. Understanding Computer-Assisted Qualitative Data Analysis Software as a Tool to Enhance Systematic Literature Reviews in Human Resource Development

Author

Paula O’Kane, Dana L. Ott, Anne D. Smith, and Travor C. Brown

Subjects
General Medicine
Abstract

Using literature reviews to identify new research avenues and provide novel theoretical insights is increasing, with the Systematic Literature Review (SLR) recently gaining greater attention from human resource development scholarship. Analyzing and making sense of literature can be insightful, but also daunting as it involves organizing and analyzing vast amounts of articles and data. Computer-Aided/Assisted Qualitative Data Analysis (CAQDAS) software can be used to support this process by organizing the literature to enable more fine-grained analysis, support analytical coding, explore patterns in the literature, and check for coding consistency. In this instructor’s corner we explain and illustrate some of the CAQDAS analysis actions that can support researchers with their SLRs.

Published
2022
Full Text
View/download PDF

20. Novel application of intravascular lithotripsy in stent under‐expansion: A single‐center experience

Author

Jonathan Hinton, Mark Mariathas, Elizabeth Chan, Amit Patel, Satnam Singh, Klio Konstantinou, Jehangir Din, Vivek Kodoth, Terry Levy, Rosie Swallow, Suneel Talwar, and Peter O'Kane

Subjects
Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine
Abstract

Stent under-expansion due to calcification is associated with a less durable result. The development of intravascular lithotripsy (IVL) has provided clinicians with a readily available, simple-to-use treatment option for coronary calcification, but the use of IVL within a previously stented segment is currently off-license. There are, however, developing data suggesting that the use of IVL can be an effective treatment option for patients with calcific stent under-expansion.This was a single-center study of all patients treated with IVL for calcific stent under-expansion between January 2019 and June 2021. The impact of IVL on quantitative coronary angiography (QCA) stenosis and on the minimal stent area (MSA) derived from intracoronary imaging were recorded. The presence of periprocedural complications and adverse cardiovascular events was obtained from the clinical record during the study timeframe.Thirty-nine patients underwent IVL for calcific stent under-expansion during the study time frame with one patient treated with more than one lesion in the same session. In all lesions, there was an improvement in the QCA stenosis with 37 (92.5%) having a residual stenosis of ≤30%. The mean QCA stenosis pre-IVL was 68 ± 21% and following IVL the mean QCA was 18 ± 9% (p 0.001). In all lesions, there was an improvement in the MSA, with 26 (92.9%) achieving an MSA of more than 4.5 mmThis single-center study demonstrates that IVL is a safe and effective treatment for calcific stent under-expansion with good medium-term results.

Published
2022
Full Text
View/download PDF

22. Comparison of Four Clinical Prognostic Scores in Patients with Advanced Gastric and Esophageal Cancer

Author

Lucy X Ma, Osvaldo Espin-Garcia, Yvonne Bach, Hiroko Aoyama, Michael J Allen, Xin Wang, Gail E Darling, Jonathan Yeung, Carol J Swallow, Savtaj Brar, Patrick Veit-Haibach, Sangeetha Kalimuthu, Rebecca Wong, Eric X Chen, Grainne M O’Kane, Raymond W Jang, and Elena Elimova

Subjects
Cancer Research, Oncology
Abstract

4057 Background: While several clinical scoring systems exist to aid prognostication and patient (pt) selection for clinical trials in oncology, none are standardly used. We compared the ability of four prognostic scores to predict overall survival (OS) in pts with advanced gastric and esophageal (GE) cancer. Methods: Pts with advanced (unresectable or metastatic) GE cancer receiving first-line palliative-intent systemic therapy at the Princess Margaret Cancer Centre from 2007 to 2020 were included. High prognostic risk pts were identified using four scoring systems: Royal Marsden Hospital (RMH), MD Anderson Cancer Centre (MDACC), Gustave Roussy Immune Score (GRIm-S) and MD Anderson Immune Checkpoint Inhibitor (MDA-ICI) score. OS was estimated using the Kaplan-Meier method and compared between risk groups (high vs. not-high) for each scoring system using the log-rank test. Cox proportional hazards models were used to analyze the association between each prognostic score and OS, adjusting for baseline clinical factors. Harrell’s c-index was used to evaluate predictive discrimination of the models. Time-dependent AUCs were used to measure predictive ability for early death (within 90 days). Results: In total, 451 pts with advanced GE cancer were included. The median age was 59 years, 68% were male, 51% had ECOG status 0-1, 63% presented with de novo metastatic disease. The proportion of pts categorized as high risk was: RMH 25% (N=113), MDACC 13% (N=95), GRIm-S 24% (N=109), MDA-ICI 26% (N=117). In all scoring systems, high risk pts had significantly shorter OS (median OS 7.9 versus 12.2 months for RMH high vs. low risk, p

Published
2022
Full Text
View/download PDF

23. Digital Mental Health and Social Connectedness

Author

Amid Ayobi, Rachel Eardley, Ewan Soubutts, Rachael Gooberman-Hill, Ian Craddock, and Aisling Ann O'Kane

Subjects
Human-Computer Interaction, Computer Networks and Communications, Social Sciences (miscellaneous)
Abstract

A detailed understanding of the mental health needs of people from refugee backgrounds is crucial for the design of inclusive mental health technologies. We present a qualitative account of the digital mental health experiences of women from refugee backgrounds. Working with community members and community workers of a charitable organisation for refugee women in the UK, we identify social and structural challenges, including loneliness and access to mental health technologies. Participants' accounts document their collective agency in addressing these challenges and supporting social connectedness and personal wellbeing in daily life: participants reported taking part in community activities as volunteers, sharing technological expertise, and using a wide range of non-mental health-focused technologies to support their mental health, from playing games to supporting religious practices. Our findings suggest that, rather than focusing only on individual self-care, research also needs to leverage community-driven approaches to foster social mental health experiences, from altruism to connectedness and belonging.

Published
2022
Full Text
View/download PDF

25. Medieval Monuments of Central Asia: Qarakhanid Architecture of the 11th and 12th Centuries, Richard Piran Mcclary (2020)

Author

Bernard O’Kane

Subjects
Urban Studies, Visual Arts and Performing Arts, Architecture, Geography, Planning and Development
Abstract

Review of: Medieval Monuments of Central Asia: Qarakhanid Architecture of the 11th and 12th Centuries, Richard Piran Mcclary (2020) Edinburgh: Edinburgh University Press, 320 pp., 83 b&w and 161 colour illus., ISBN: 9781474423977, £95 (hardback)

Published
2023
Full Text
View/download PDF

26. Evaluation of Clinical Outcomes of Intravenous Drug Use-Related Infective Endocarditis in Buprenorphine-Treated Patients

Author

Cavan O'Kane, Kara Piechowski, Abigail Hoff, Wei Fang, Zebulun Mallow, Patrick Marshalak, and Sheena Burwell

Subjects
Adult, Pharmacology, Endocarditis, Humans, Pharmaceutical Science, Opioid-Related Disorders, Substance Abuse, Intravenous, Buprenorphine, Retrospective Studies
Abstract

Purpose: Intravenous drug use (IVDU) is an independent risk factor for infective endocarditis (IE). IVDU-related IE is associated with poor clinical outcomes, such as infection-related and drug abuse-related readmissions and mortality. Critical interventions to treat addiction, such as medication for opioid use disorder (MOUD) with buprenorphine, may prevent these unfavorable outcomes. This study aimed to establish the effectiveness of buprenorphine prescriptions at hospital discharge for patients admitted for IVDU-related IE. Methods: A single center, retrospective cohort study evaluated the effectiveness of discharge prescriptions of buprenorphine in adult patients (≥18 years of age) with OUD and IVDU-related IE. Outcomes of 30-day readmissions, 180-day readmissions, and mortality were compared to a cohort of patients who were not prescribed buprenorphine at hospital discharge. Results: The primary endpoint of all cause 30-day readmission was lower in patients who received buprenorphine (n=11/122, 9%) at hospital discharge for IVDU-related IE compared to those who did not (n=9/48, 19%), although not statistically significant (unadjusted OR 0.429, 95% CI 0.165-1.138, p=0.082). After accounting for intensive care admission, infusion unit admission, and psychiatry consultation, the odds of all cause 30-day readmission were statistically lower in patients prescribed buprenorphine (adjusted OR 0.337, 95% CI 0.125-0.909, p=0.029). Additionally, significantly more patients prescribed buprenorphine at discharge followed-up in an outpatient treatment program, 57% and 15% respectively (p

Published
2022
Full Text
View/download PDF

27. Introduction: Eritrea’s Uneasy Futures and their Historical Contingencies

Author

David O’Kane, Sabine Mohamed, and Magnus Treiber

Subjects
Cultural Studies, History, Sociology and Political Science, Anthropology, Development
Abstract

To introduce this special issue of Modern Africa, the editors review Eritrea’s current condition and consider its historical roots: they place this Horn of Africa state in a broader historical context, one where neither relevant comparative cases nor past precedents are limited to its region. Hopes that were once invested in Eritrea as a model developmental state have now, thirty years since its independence, been thoroughly disappointed. The human rights violations and persistent underdevelopment that make an Eritrean transition necessary are very real: equally real are the risks and dangers that would be involved in any such transition. Recent cases of failed transition are discussed here: so too are the possible routes Eritrea might take to a “developmental democracy.” This issue’s various contributions are then introduced and summarised.

Published
2022
Full Text
View/download PDF

28. Moving the Needle on Precision Medicine in Pancreatic Cancer

Author

Grainne M. O'Kane and Maeve A. Lowery

Subjects
Pancreatic Neoplasms, Proto-Oncogene Proteins p21(ras), Cancer Research, Oncology, Humans, Precision Medicine, Carcinoma, Pancreatic Ductal
Abstract

The management of pancreatic ductal adenocarcinoma (PDAC) has posed a considerable challenge for decades, with incidence and mortality rates almost mirroring each other. Despite this, a deeper understanding of the complex biology inherent to PDAC has provided a roadmap for a more precise approach to treatment. PDAC deficient in homologous recombination repair and mismatch repair is a subgroup that should be identified in the clinic for a targeted approach. In addition, KRAS wild-type PDAC, occurring in approximately 10% of patients, is enriched in highly actionable alterations including fusions, underscoring the importance of integrative germline and somatic sequencing. Comprehensive sequencing efforts over the past decade have documented genomic- and transcriptomic-based classifiers, with the latter emerging as two main subtypes: the classical and basal-like, which are now being evaluated in clinical trials. Together with promising, innovative strategies to target KRAS mutations and their pleotropic effects, a new era of precision medicine in PDAC is on the horizon.

Published
2022
Full Text
View/download PDF

30. Nonplanar Spray-Coated Perovskite Solar Cells

Author

Timothy Thornber, Onkar S. Game, Elena J. Cassella, Mary E. O’Kane, James E. Bishop, Thomas J. Routledge, Tarek I. Alanazi, Mustafa Togay, Patrick J. M. Isherwood, Luis C. Infante-Ortega, Deborah B. Hammond, John M. Walls, and David G. Lidzey

Subjects
General Materials Science
Abstract

Spray coating is an industrially mature technique used to deposit thin films that combines high throughput with the ability to coat nonplanar surfaces. Here, we explore the use of ultrasonic spray coating to fabricate perovskite solar cells (PSCs) over rigid, nonplanar surfaces without problems caused by solution dewetting and subsequent "run-off". Encouragingly, we find that PSCs can be spray-coated using our processes onto glass substrates held at angles of inclination up to 45° away from the horizontal, with such devices having comparable power conversion efficiencies (up to 18.3%) to those spray-cast onto horizontal substrates. Having established that our process can be used to create PSCs on surfaces that are not horizontal, we fabricate devices over a convex glass substrate, with devices having a maximum power conversion efficiency of 12.5%. To our best knowledge, this study represents the first demonstration of a rigid, curved perovskite solar cell. The integration of perovskite photovoltaics onto curved surfaces will likely find direct applications in the aerospace and automotive sectors.

Published
2022
Full Text
View/download PDF

31. Murine models of radiation cardiotoxicity: A systematic review and recommendations for future studies

Author

Gerard M. Walls, Reagan O'Kane, Mihaela Ghita, Refik Kuburas, Conor K. McGarry, Aidan J. Cole, Suneil Jain, and Karl T. Butterworth

Subjects
Disease Models, Animal, Mice, Oncology, Animals, Heart, Radiology, Nuclear Medicine and imaging, Dose Fractionation, Radiation, Hematology, Radiometry, Cardiotoxicity, Rats
Abstract

BACKGROUND AND PURPOSE: The effects of radiation on the heart are dependent on dose, fractionation, overall treatment time, and pre-existing cardiovascular pathology. Murine models have played a central role in improving our understanding of the radiation response of the heart yet a wide range of exposure parameters have been used. We evaluated the study design of published murine cardiac irradiation experiments to assess gaps in the literature and to suggest guidance for the harmonisation of future study reporting.METHODS AND MATERIALS: A systematic review of mouse/rat studies published 1981-2021 that examined the effect of radiation on the heart was performed. The protocol was published on PROSPERO (CRD42021238921) and the findings were reported in accordance with the PRISMA guidance. Risk of bias was assessed using the SYRCLE checklist.RESULTS: 159 relevant full-text original articles were reviewed. The heart only was the target volume in 67% of the studies and simulation details were unavailable for 44% studies. Dosimetry methods were reported in 31% studies. The pulmonary effects of whole and partial heart irradiation were reported in 13% studies. Seventy-eight unique dose-fractionation schedules were evaluated. Large heterogeneity was observed in the endpoints measured, and the reporting standards were highly variable.CONCLUSIONS: Current murine models of radiation cardiotoxicity cover a wide range of irradiation configurations and latency periods. There is a lack of evidence describing clinically relevant dose-fractionations, circulating biomarkers and radioprotectants. Recommendations for the consistent reporting of methods and results of in vivo cardiac irradiation studies are made to increase their suitability for informing the design of clinical studies.

Published
2022
Full Text
View/download PDF

32. A Case Study Investigating a User-Centred and Expert Informed 'Companion Guide' for a Complex Sensor-based Platform

Author

Rachel Eardley, Sue Mackinnon, Emma L. Tonkin, Ewan Soubutts, Amid Ayobi, Jess Linington, Gregory J. L. Tourte, Zoe Banks Gross, David J. Bailey, Russell Knights, Rachael Gooberman-Hill, Ian Craddock, and Aisling Ann O'Kane

Subjects
Human-Computer Interaction, Computer Networks and Communications, Hardware and Architecture
Abstract

We present a case study that informs the creation of a 'companion guide' providing transparency to potential non-expert users of a ubiquitous machine learning (ML) platform during the initial onboarding. Ubiquitous platforms (e.g., smart home systems, including smart meters and conversational agents) are increasingly commonplace and increasingly apply complex ML methods. Understanding how non-ML experts comprehend these platforms is important in supporting participants in making an informed choice about if and how they adopt these platforms. To aid this decision-making process, we created a companion guide for a home health platform through an iterative user-centred-design process, seeking additional input from platform experts at all stages of the process to ensure the accuracy of explanations. This user-centred and expert informed design process highlights the need to present the platform's entire ecosystem at an appropriate level for those with differing backgrounds to understand, in order to support informed consent and decision making.

Published
2022
Full Text
View/download PDF

35. Response of the Jovian radio emission to magnetospheric disturbances inferred from in situ Juno observations

Author

Corentin Louis, Caitriona Jackman, George Hospodarsky, Aoife O'Kane Hackett, Elliot Devon-Hurley, Philippe Zarka, William Kurth, Robert Ebert, Dale Weigt, Alexandra Fogg, James Waters, Seán McEntee, John Connerney, Philippe Louarn, Steven Levin, and Scott Bolton

Abstract

During its 53-day polar orbit around Jupiter, Juno often crosses the boundaries of the Jovian magnetosphere, namely the magnetopause and bow shock, as well as the plasma disc (located at the centrifugal equator). The positions of the magnetopause and bow shock allow us to determine the dynamic pressure of the solar wind (using both the updated model of Joy et al. 2002 by Ranquist et al., 2020 and/or in situ data) which allows us to infer magnetospheric compression or relaxation, while the observations of plasma disc perturbations allows us to infer magnetospheric reconfigurations.The aim of this study is to examine Jovian radio emissions during magnetospheric perturbations. We then use our analysis to determine the relationship between the solar wind and Jovian radio emissions (observed and emitted from different regions of the magnetosphere, from different mechanisms, and at different wavelengths from kilometers to decameters).In this presentation, we show case studies for each typical case (bow shock, magnetopause and plasma disk crossings) and show that the activation of new radio sources is related to magnetospheric disturbances. By performing a statistical study of these crossings, we show the relationship between the activation of new radio sources (emission intensity and extension, source positions) and the solar wind (dynamic pressure, magnetic intensity, …). The final aim is to be able to use observations of planetary radio emission as a proxy for the solar wind conditions.

Published
2023
Full Text
View/download PDF

37. The challenges of a randomised placebo-controlled trial of CTO PCI vs. placebo with optimal medical therapy: The ORBITA-CTO pilot study design and protocol

Author

Khan, Sarosh, Fawaz, Samer, Simpson, Rupert, Robertson, Craig, Kelly, Paul, Mohdnazri, Shah, Tang, Kare, Cook, Christopher M., Gallagher, Sean, O’Kane, Peter, Spratt, James, Brilakis, Emmanouil S., Karamasis, Grigoris V., Al-Lamee, Rasha, Keeble, Thomas R., and Davies, John R.

Subjects
Cardiology and Cardiovascular Medicine
Abstract

BackgroundPercutaneous coronary intervention (PCI) for coronary chronic total occlusion (CTO) has been performed for the improvement of symptoms and quality of life in patients with stable angina. The ORBITA study demonstrated the role of the placebo effect in contemporary PCI in non-CTO chronic coronary syndromes. However, the benefit of CTO PCI beyond that of a placebo has not been demonstrated.AimsThe ORBITA-CTO pilot study will be a double-blind, placebo-controlled study of CTO PCI randomising patients who have: (1) been accepted by a CTO operator for PCI; (2) experienced symptoms due to a CTO; (3) evidence of ischaemia; (4) evidence of viability within the CTO territory; and (5) a J-CTO score ≤3.MethodsPatients will undergo medication optimisation that will ensure they are on at least a minimum amount of anti-anginals and complete questionnaires. Patients will record their symptoms on an app daily throughout the study. Patients will undergo randomisation procedures, including an overnight stay, and be discharged the following day. All anti-anginals will be stopped after randomisation and re-initiated on a patient-led basis during the 6-month follow-up period. At follow-up, patients will undergo repeat questionnaires and unblinding, with a further 2-week unblinded follow-up.ResultsThe co-primary outcomes are feasibility (blinding) in this cohort and angina symptom score using an ordinal clinical outcome scale for angina. Secondary outcomes include changes in quality-of-life measures, Seattle Angina Questionnaire (SAQ), peak VO2, and anaerobic threshold on the cardiopulmonary exercise test.ConclusionThe feasibility of a placebo-controlled CTO PCI study will lead to future studies assessing efficacy. The impact of CTO PCI on angina measured using a novel daily symptom app may provide improved fidelity in assessing symptoms in patients with CTO's.

Published
2023
Full Text
View/download PDF

38. Regional variation in characteristics of patients with decompensated cirrhosis admitted to hospitals in the UK

Author

Oliver D Tavabie, Kushala WM Abeysekera, Paul N Brennan, Thomas Marjot, Victoria T Kronsten, Wenhao Li, Jeremy S Nayagam, Amritpal Dhaliwal, Tim Hardy, James B Maurice, Nekisa Zakeri, Nadir Abbas, Abdullah Abbasi, Jane Abbott, Rahman Abdul, Mohamed Abdulaziz, Duaa Abduljabbar, Robbie Adamson, Danielle Adebayo, Aditya Kumar Adhikarla, Maciej Adler, Mostafa Afifi, Salman Ahmad, Shayan Ahmed, Guruprasad Aithal, Ali Akram, Balqees Al Radhi, Ismaeel Al-Talib, Jolomi Alele, Alaa Mohammed Ali, Safa Almusai, Victoria Appleby, Huma Asmat, Sarah Astbury, Ali Atkinson, Fakhirah Badrulhisham, Vinay K Balachandrakumar, Alexandra Ball, Moses Banfa, Jeevan Barn, Shahnaz Begum, Katherine Belfield, Oliver Bendall, Kris Bennett, William Bernal, Rajan Bhandari, Prashan Bhatti, Meg Bradley, Edward Brown, Kathleen Bryce, Ryan Buchanan, Laura Burke, Roisin Campbell, Tamsin Cargill, Geraldine Carroll, James Cartledge, Devnandan Chatterjee, Rayan Chaundry, Zeshan Choudhry, Kathleen Clare, Jeremy Cobbold, Robert Coburn, Charlotte Cook, Fintan Corvan, Rebecca Cox, Darren Craig, John Creamer, Christopher Curran, Shanika De Silva, Laurence Dean, Jayne Dillon, John Dillon, Rebecca Dunn, Robert Eckersley, Gidveig Eike, Amul Elagib, Ayman Elkholi, Omar Elshaarawy, Sarah Faloon, Francis Fan, Mohammad Fazili, Denzil Fernandes, James Fox, Matthew Foxton, Waqas Gaba, Girish Gaikwad, Abishek Gairola, Vasileios Galanakis, Charles Gallaher, Nisham Gautam, Lewis Germain, Ben Giles, Ceri Gill, Ben Glover, John Glover, David Gomez, Michael Gomez, Victoria Gordon, Sarah Gormley, John Goulder, Simran Goyal, Olivia Greenham, Sarah Guthrie, Richard Hackett, Yazan Haddadin, Andreas Hadjinicolaou, Jonathan Hall, Mohammed Hamza, Tasnuma Haque, Rebecca Harris, Catherine Hart, Sundas Hasan, Syed Mujtaba Hasnain Nadir, James Hassall, George Hawker-Bond, Jake Hawkyard, Scott Healey, Brian Hogan, Catherine Hornby, MD Humayun, John Hutchison, Zahra Iftikhar, Asem Ismail, Joel James, Rebecca Jones, Laura Jopson, Dipal Juthani, Philippa Kaina, Aadil Karim, Syed Misbah Karim, Vaishnavi Kashyap, Mohamed Kassab, Dev Katarey, Lee Kenny, Georgina Kerry, Adnan Khan, Ayesha Khan, Azab Khan, Muhammad Taha Khan, Tahir Khan, Aseil Khatib, Mohammad Fawad Khattak, Ji Jade King, Emily Kooner, Mohammed Korani, Sreelakshmi Kotha, Wai Liam Lam, Mohammed Lateef, Jess Leighton, Damien Leith, Angela Liaros, James Liu Yin, Floyd Lourenco, Annabel Lyles, Lucia Macken, Ciaran Magee, Daniel Maggs, Aarani Mahalingam, Midusa Mahenthiran, Rizwan Mahmood, Mandour Omer Mandour, Namita Manocha, Dina Mansour, Daniella Marks, Ciara Martin, Harry Martin, Iana Martin, Katherine Martin, Sachan Maruthan, Rhys Masin, Denise Mason, Charmaine Matthews, Athina Mavrou, Ema Maxan, Dominic Maxfield, Emma McAvoy, Hannah McCaughan, Kirsty McColl, Roger McCorry, Stewart McDonald, Hannah McDowell, John McGoran, Stewart McIlwane, Stuart McPherson, Olivia Meakin, Leila Mebarek, Hannah Merrill, Stephanie Michail, Pedram Modarres, Alaa Mohamedali, Yaser Mohammed, Zakiuddin Mohammed, Jaiganesh Mohan, Chloe Monnier, Eilis Moran, Francesca Moroni, Gary Morrison, Anas Msaddi, Sarah Mutar, Ismail Nahed, Janardhan Navaratnam, Luis Neto-Pereira, Jennifer Ng, Chinonso Nwoguh, Rebecca O'Kane, Sohail Omar, Abosede Ososanya, Jessiya Veliyankodan Parambil, Jay Patel, Marinos Pericleous, Zeshan Pervais, Anju Phoolchund, Julian Pietrzycki, Lushen Pillay, Keith Pohl, Kiran Prabhu, Yesita Rizky F. Putri, Umang Qazi, Khizar Khalid Rafique, Arun Raghuraman, Krithivasan Raman, Vaishali Ranade, Francesca Rastelli, Elizabeth Ratcliffe, Deepa Rattehalli, Tufail Raza, Amir Razak, George Read, Anne Robins, Ian Rowe, Simon Rushbrook, Mohamed Salama, Ramasamy Saravan, Srishti Sarkar, Emma Saunsbury, Jennifer Scott, Solange Serna, Hassnain Shahzad, Mohammed Shamsaldeen, Mohammed Sharip, Jessica Shearer, Adam Sheikh, Giovanna Sheiybani, Michelle Sherwin, Abhishek Sheth, Nidhi Shintre, Saket Singhal, Rohit Sinha, Ricky Sinharay, Gloria Smith, Ria Smith, Victoria Snowdon, Joanne Spicer, Johannes Spoor, Shiva Sreenivasan, Amar Srinivasa, Ankur Srivastava, Louise St. Aimee, Georgia Stagg, Jatinder Stanley, Jason Stevenson, Daniel Stokes, Robert Stroud, Mohsan Subhani, Hiba Suliman, Marium Sultana, Nikki Summers, Chloe Sutherland, Rachael Swann, Lynne Sykes, Mostafa Taha, Kwei Eng Tan, Zohaib Tariq, Joshua Jun Ming Tay, Alison Taylor, Amit Thakor, James Tsang, Lucy Turner, Zaccharie Tyler, Esther Unitt, Edward Volcek, Iona Watson, Chris Watters, Gemma Wells, Helen White, Monika Widlak, Matthew Williams, Jack Wischhusen, Hazel Woodland, Louise Wren, Souzana Xyda, Julian Yeh, Alison Young, and Jack Shie Jie Yuan

Subjects
Hepatology, Gastroenterology
Published
2023
Full Text
View/download PDF

41. Transcriptomic Signatures of Lung Stretch

Author

P. Martín, C. López-Martínez, L. Amado-Rodríguez, I. López-Alonso, M. Fernández, A. González-López, P. Martínez-Camblor, A. Boyle, C. O'Kane, D. F McAuley, J. N Tsoporis, C. Dos Santos, and G.M. Albaiceta

Published
2023
Full Text
View/download PDF

43. Successful surgical management of a combined abdominal and thoracic penetrating injury: a case report

Author

Zamaan Hooda, Lisa O’kane, John Paul Bustamante, Bledi Zaku, Jideofor Aniukwu, Scott Wessner, and Luis Cerda

Subjects
Surgery
Abstract

Penetrating rebar injuries are extremely rare occurrences, but they are very life-threatening, particularly when involving the thoracic and abdominal cavities. The surgical approach to these traumatic injuries depends upon the length and diameter of the rebar as well as the path of penetration into the abdominal and thoracic regions. Due to the highly uncommon occurrence of penetrating rebar injuries, there is very limited information and studies pertaining to this topic in the literature. In this case report, we present a 43-year-old male patient sustaining a rebar penetrating injury, with the entry site being the left flank and the exit site being the anterior left chest. Upon arrival, the patient was emergently taken to the operating room and underwent simultaneous exploratory laparotomy and a left thoracotomy. The operation was successful in removing the rebar and the patient survived.

Published
2023
Full Text
View/download PDF

44. Pressure-Stress Evaluation of Wells Drilled at the Angore Field, Western Fold Belt, PNG

Author

Stephen Leslie Karner, Jonathan A Giddings, Tomas P O’Kane, Matt Durrant, Brian J Darby, and Karthikeyan G

Abstract

Objectives/Scope Thirteen ExxonMobil-operated gas development wells were drilled from 2012 to 2015 at the onshore Hides and Angore gas fields, Papua New Guinea (PNG), as part of the PNG LNG drilling program. Prior to drilling the PNG LNG wells, four wells had penetrated the Hides structure and one well had penetrated Angore. This paper focuses on pressure-stress interpretations at Angore, using drilling observations and data collected from the final three wells of the PNG LNG drilling program. Methods, Procedures, Process The pressure-stress analyses of the PNG LNG Angore wells incorporated data collected while drilling, post-drill geologic and structural interpretations, and utilized a variety of geomechanical concepts that were constrained by the well data. Post-drill formation pressures were either estimated (e.g. from petrophysical trends, mud-log data, cavings analysis, formation fluid influxes) or directly measured using downhole pressure tools (reservoir only). Rock stresses were estimated or inferred from geomechanical relationships that were constrained by wellbore data (e.g. leak-off tests, mud weights), wellbore geometry (e.g. ovalization related to breakout), cavings analysis, and drilling events (e.g. lost returns, ballooning). Results, Observations, Conclusions The Angore well pads were constructed on Miocene Darai Limestone. Below the Darai Limestone, the wells penetrated a clastic section consisting of Cretaceous Ieru Formation (Haito, Ubea, Giero, Bawia, Juha, Alene Members), early Cretaceous Toro sandstone reservoir, and Jurassic Imburu Formation. The initial exploration well (Angore 1A drilled by BP in 1990) encountered a complex pressure-stress depth profile that was comparable to nearby offset wells. Hydrostatic pressure occurs below the water table (in the Darai Limestone) and continues into the Ubea Member. The clay-rich lower Ubea Member supports the onset of a pressure ramp that reaches maximum excess pressure in the Giero Member. Elevated excess pressures persist to the lower Alene Member at which point a pressure regression occurs into the Toro Sandstone and upper Imburu Formation. The first Angore well of the PNG LNG program (Angore B1) encountered a level of structural complexity together with extreme pressures and stresses that were not anticipated prior to drilling. Due to these complexities, the target reservoir was not reached and the well was plugged and suspended. Two subsequent wells (Angore A1 and A2) encountered similar tectonic complexity, but successfully drilled through the extreme conditions to reach the reservoir. Novel/Additive Information The analyses from Angore support a geomechanical model that involves an interplay between structural history and mechanical stratigraphy, insofar as: 1) formation pressure and stress regime varies with depth and lithology; 2) stratigraphic mechanical properties and structural geometry allow for a non-Andersonian stress state (minimum stress exceeded overburden); 3) stress magnitude may be controlled by fault geometry/timing and formation excess pressure; and 4) parts of the structure may be presently close to Mohr-Coulomb failure.

Published
2023
Full Text
View/download PDF

46. Exploring the attitudes of general dental practitioners to providing dietary advice alongside oral rehabilitation for older adults

Author

Ruairí O’Kane, Sinead Watson, Jayne Woodside, and Gerald J. McKenna

Subjects
Geriatrics and Gerontology, General Dentistry
Abstract

ObjectiveWe aimed to capture General Dental Practitioners' (GDPs) views on delivering dietary advice to older adults in combination with treatment to replace missing teeth and identify solutions to help inform the development and implementation of future dietary interventions within primary dental care.BackgroundAs natural teeth are lost, older adults may need to choose softer, more manageable foods which might be of lower nutrient density. Previous research has indicated that prosthodontic rehabilitation can improve masticatory function but not the intake of nutrients, highlighting a potential need for a combined approach of oral rehabilitation and dietary counselling.Materials and MethodsSemi-structured telephone interviews were conducted with a purposive sampling strategy of 12 GDPs. Interviews were digitally recorded and transcribed verbatim. An iterative coding process using theme-analytic methods was used.ResultsTwelve interviews were conducted with GDPs in the United Kingdom. The themes that emerged from the interviews included: the awareness of the importance of dietary advice among GDPs; the concerns GDPs had on patients' adherence to dietary advice; uncertainty over roles and responsibilities in the provision of dietary advice; and the limited time and remuneration for dietary advice in dental practice. A minor theme identified was the motivation of GDPs to implement dietary advice alongside oral rehabilitation. All reported that they were already providing dietary advice to their patients but that this was limited to caries prevention.ConclusionThe GDPs interviewed expressed positive attitudes towards providing dietary advice alongside oral rehabilitation for older adults. However, a lack of confidence, awareness, time and remuneration are barriers to its provision in primary dental care. To facilitate the implementation of dietary advice alongside oral rehabilitation, clear guidance on and training in delivering dietary advice and multidisciplinary cooperation are required.

Published
2023
Full Text
View/download PDF

47. Supplementary table 1 and figures 1-4 from Endogenous Retrovirus Transcript Levels Are Associated with Immunogenic Signatures in Multiple Metastatic Cancer Types

Author

Daniel J. Renouf, David F. Schaeffer, Steven J.M. Jones, Marco A. Marra, Janessa Laskin, Dixie L. Mager, Jonathan M. Loree, Steven Gallinger, Jennifer J. Knox, Grainne M. O'Kane, Andrew J. Mungall, Richard A. Moore, Hui-Li Wong, Steve E. Kalloger, Gun-Ho Jang, Robert E. Denroche, Shehara Mendis, Michael K.C. Lee, Luka Culibrk, Joanna M. Karasinska, Laura M. Williamson, Erin D. Pleasance, Emma Titmuss, and James T. Topham

Abstract

Supplemental Table S1 lists clinical characteristics for the study cohort. Figure S1 depicts results of batch correction. Figures S2 and S3 show comparisons between ERV levels and tumor content. Figure S4 shows ERV levels across different biopsy sites.

Published
2023
Full Text
View/download PDF

48. Supplemental Figures from Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer

Author

David A. Tuveson, Steven Gallinger, Alexander Krasnitz, Jennifer Knox, Richard Moffitt, Julie M. Wilson, Sandra E. Fischer, Benjamin Hubert, Christopher R. Vakoc, Ellen Li, Kenneth H. Yu, Christopher L. Wolfgang, Allyson Ocean, Craig Devoe, James M. Crawford, Edward Kim, Faiyaz Notta, Grainne M. O'Kane, Michael A. Hollingsworth, Jonathan R. Brody, Paul M. Grandgenett, Jonathan M. Buscaglia, Dominick J. DiMaio, Jean L. Grem, Phyllis A. Gimotty, Jordan M. Winter, James D. Sullivan, William Nealon, Divyesh V. Sejpal, Peter Allen, Juan Carlos Bucobo, Maoxin Wu, Joseph Kim, Aaron Sasson, Brian M. Wolpin, Andrew J. Aguirre, Elizabeth Thompson, Ralph H. Hruban, Laura D. Wood, Hans Clevers, Christine A. Iacobuzio-Donahue, Gokce Askan, Nicolas LeComte, Else Driehuis, Laura Martello, Cinthya Y. Lowder, Austin B. Goetz, Rashesh Sanghvi, Minita Shah, Nicolas Robine, Kanika Arora, Molly Johnson, Jasmine C. Huynh, Ammar A. Javed, Randze Lerie D. Palmaira, Joseph F. LaComb, Michelle Ma, Hardik Patel, C. Megan Young, Koji Miyabayashi, Gun-Ho Jang, Robert E. Denroche, Richard A. Burkhart, Fieke E. M. Froeling, Tim D. D. Somerville, Astrid Deschênes, Dennis Plenker, Dannielle D. Engle, Pascal Belleau, and Hervé Tiriac

Abstract

Supplemental Figures

Published
2023
Full Text
View/download PDF

49. Table S3 from Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer

Author

David A. Tuveson, Steven Gallinger, Alexander Krasnitz, Jennifer Knox, Richard Moffitt, Julie M. Wilson, Sandra E. Fischer, Benjamin Hubert, Christopher R. Vakoc, Ellen Li, Kenneth H. Yu, Christopher L. Wolfgang, Allyson Ocean, Craig Devoe, James M. Crawford, Edward Kim, Faiyaz Notta, Grainne M. O'Kane, Michael A. Hollingsworth, Jonathan R. Brody, Paul M. Grandgenett, Jonathan M. Buscaglia, Dominick J. DiMaio, Jean L. Grem, Phyllis A. Gimotty, Jordan M. Winter, James D. Sullivan, William Nealon, Divyesh V. Sejpal, Peter Allen, Juan Carlos Bucobo, Maoxin Wu, Joseph Kim, Aaron Sasson, Brian M. Wolpin, Andrew J. Aguirre, Elizabeth Thompson, Ralph H. Hruban, Laura D. Wood, Hans Clevers, Christine A. Iacobuzio-Donahue, Gokce Askan, Nicolas LeComte, Else Driehuis, Laura Martello, Cinthya Y. Lowder, Austin B. Goetz, Rashesh Sanghvi, Minita Shah, Nicolas Robine, Kanika Arora, Molly Johnson, Jasmine C. Huynh, Ammar A. Javed, Randze Lerie D. Palmaira, Joseph F. LaComb, Michelle Ma, Hardik Patel, C. Megan Young, Koji Miyabayashi, Gun-Ho Jang, Robert E. Denroche, Richard A. Burkhart, Fieke E. M. Froeling, Tim D. D. Somerville, Astrid Deschênes, Dennis Plenker, Dannielle D. Engle, Pascal Belleau, and Hervé Tiriac

Abstract

Table S3

Published
2023
Full Text
View/download PDF

50. Supplementary Table 3 from Endogenous Retrovirus Transcript Levels Are Associated with Immunogenic Signatures in Multiple Metastatic Cancer Types

Author

Daniel J. Renouf, David F. Schaeffer, Steven J.M. Jones, Marco A. Marra, Janessa Laskin, Dixie L. Mager, Jonathan M. Loree, Steven Gallinger, Jennifer J. Knox, Grainne M. O'Kane, Andrew J. Mungall, Richard A. Moore, Hui-Li Wong, Steve E. Kalloger, Gun-Ho Jang, Robert E. Denroche, Shehara Mendis, Michael K.C. Lee, Luka Culibrk, Joanna M. Karasinska, Laura M. Williamson, Erin D. Pleasance, Emma Titmuss, and James T. Topham

Abstract

Supplemental Table S3 lists gene sets significantly enriched among genes up-regulated in VMP samples.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results