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Over the last fifteen years, genomics has become fully integrated into prokaryotic systematics. The genomes of most type strains have been sequenced, genome sequence similarity is widely used for delineation of species, and phylogenomic methods are commonly used for classification of higher taxonomic ranks. Additionally, environmental genomics has revealed a vast diversity of as-yet-uncultivated taxa. In response to these developments, a new code of nomenclature, the Code of Nomenclature of Prokaryotes Described from Sequence Data (SeqCode), has been developed over the last two years to allow naming of Archaea and Bacteria using DNA sequences as the nomenclatural types. The SeqCode also allows naming of cultured organisms, including fastidious prokaryotes that cannot be deposited into culture collections. Several simplifications relative to the International Code of Nomenclature of Prokaryotes (ICNP) are implemented to make nomenclature more accessible, easier to apply and more readily communicated. By simplifying nomenclature with the goal of a unified classification, inclusive of both cultured and uncultured taxa, the SeqCode will facilitate the naming of taxa in every biome on Earth, encourage the isolation and characterization of as-yet-uncultivated taxa, and promote synergies between the ecological, environmental, physiological, biochemical, and molecular biological disciplines to more fully describe prokaryotes., Funding was provided by the US National Science Foundation (DEB 1841658 and EAR 1516680), the US National Institute of General Medical Sciences (P20 GM103440) from the National Institutes of Health, the Spanish Ministry of Science, Innovation and Universities (PID2021-126114NB-C42), the Australian Research Council (FL150100038), the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation, SFB 1439/1 2021 – 426547801) also supported with European Regional Development Funds (FEDER), and the International Society for Microbial Ecology (ISME)