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Globally, science curricula have been described as outdated, and students perceive school science as lacking in relevance. Declines in senior secondary and tertiary student participation in science indicate an urgent need for change if we are to sustain future scientific research and development, and perhaps more importantly, to equip students with the knowledge and skills to make informed decisions related to scientific research. This paper argues that a good starting point would be the inclusion of more contemporary areas of science in middle school curricula. One such area with continually emerging developments is biotechnology. This paper further argues the need for research into the impact of biotechnology education that would allow students to go beyond learning about biotechnological processes and products to explore their benefits and risks through an integrated approach, where biotechnology education were extended to include subject areas beyond science, such as social sciences, health education, and English. Such an approach is important, in light of research that suggests that the general public has a limited understanding of biotechnology and that public dissemination of information is insufficient to allow individuals to make informed decisions about or to develop attitudes towards, the varied applications of biotechnology. If we are to educate students to be tomorrow's informed decision-makers, we must start by addressing their understanding of and attitudes towards emerging sciences. Further research is needed to broaden our understanding of how to achieve these goals. © 2011 The Australian Association for Research in Education, Inc.

Optimal T cell activation and expansion require engagement of the TCR plus costimulatory signals delivered through accessory molecules. SLAM (signaling lymphocytic activation molecule), a 70-kDa costimulatory molecule belonging to the Ig superfamily, was defined as a human cell surface molecule that mediated CD28-independent proliferation of human T cells and IFN-γ production by human Th1 and Th2 clones. In this study, we describe the cloning of mouse SLAM and the production of mAb against it which reveal its expression on primary mouse T and B cells. Mouse SLAM is expressed on highly polarized Th1 and Th2 populations, and is maintained on Th1, but not on Th2 clones. Anti-mouse SLAM mAb augmented IFN-γ production by Th1 cells and Th1 clones stimulated through the TCR, but did not induce IFN-γ production by Th2 cells, nor their production of IL-4 or their proliferation. Mouse SLAM is a 75-kDa glycoprotein that upon tyrosine phosphorylation associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, but not SHP-1. Mouse SLAM also associates with the recently described human SLAM-associated protein. These studies may provide new insights into the regulation of Th1 responses.1 DNAX is supported by the Schering Plough Research Institute. T.M.H. was initially funded by fellowships from the Swiss National Science Foundation and from the Roche Research Foundation, Switzerland. Abbreviations used in this paper: SLAM, signaling lymphocytic activation molecule; AP, alkaline phosphatase; h, human; m, mouse; SAP, SLAM-associated protein; SH2, Src homology 2; SHP, SH2 domain-bearing protein tyrosine phosphatase; XLP, X-linked lymphoproliferative disease; PIG, phosphatidylinositol glycan.