1. Immunity to Campylobacter: its role in risk assessment and epidemiology
- Author
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Havelaar, Arie H, van Pelt, Wilfrid, Ang, C Wim, Wagenaar, Jaap A, van Putten, Jos P M, Gross, Uwe, Newell, Diane G, LS IRAS VPH MBR (microbiol.risico sch.), LS Klinisch Onderzoek Wagenaar, LS Infectiebiologie (Bacteriologie), Medical Microbiology and Infection Prevention, CCA - Immuno-pathogenesis, LS IRAS VPH MBR (microbiol.risico sch.), LS Klinisch Onderzoek Wagenaar, and LS Infectiebiologie (Bacteriologie)
- Subjects
Biomedical Research ,Biomedical Research/methods ,medicine.disease_cause ,Applied Microbiology and Biotechnology ,Epidemiology ,Campylobacter Infections ,Medicine ,jejuni infection ,dose-response ,0303 health sciences ,outer-membrane proteins ,Incidence (epidemiology) ,Campylobacter ,guillain-barre-syndrome ,Incidence ,Age Factors ,General Medicine ,Acquired immune system ,3. Good health ,human-antibody response ,Risk assessment ,Risk analysis ,ID - Infectieziekten ,medicine.medical_specialty ,Coronacrisis-Taverne ,Campylobacteriosis ,reactive arthritis patients ,Microbiology ,Risk Assessment ,03 medical and health sciences ,Immunity ,Environmental health ,Humans ,Developing Countries ,030304 developmental biology ,Campylobacter/immunology ,inflammatory-bowel-disease ,030306 microbiology ,business.industry ,Infant, Newborn ,western-blot-analysis ,Infant ,Campylobacter Infections/epidemiology ,biochemical phenomena, metabolism, and nutrition ,Newborn ,medicine.disease ,Epidemiologic Research Design ,Immunology ,intestinal epithelial-cells ,business ,linked-immunosorbent-assay - Abstract
Acquired immunity is an important factor in the epidemiology of campylobacteriosis in the developing world, apparently limiting symptomatic infection to children of less than two years. However, also in developed countries the highest incidence is observed in children under five years and the majority of Campylobacter infections are asymptomatic, which may be related to the effects of immunity and/or the ingested doses. Not accounting for immunity in epidemiological studies may lead to biased results due to the misclassification of Campylobacter-exposed but apparently healthy persons as unexposed. In risk assessment studies, health risks may be overestimated when immunity is neglected.
- Published
- 2009