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Your search keyword '"Nelemans P"' showing total 3 results
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3 results on '"Nelemans P"'

1. Eleventh Meeting of the European Venous Forum: Antwerp, Belgium, 24–26 June 2010

Author

Deatrick, K., Baker, N., Deroo, S., Elfline, M. A., Sood, V., Stabler, S., Blackburn, S. A., Luke, C. E., Wakefield, T. W., Henke, P. K., Pannucci, C. J., Bailey, S., Fisher, C., Clavijo-Alvarez, J., Hamill, J., Hume, K., Wakefield, T., Rubin, J., Wilkins, E., Hoxworth, R., Sfyroeras, G. S., Rubio, V., Ravi, R. D., Pittaluga, P., Chastanet, S., Locret, T., Rousset, O., Kordowicz, A., Ferguson, G., Salaman, R., Onwudike, M., Gauw, S. A., Fens, N., Knobel, H. H., de Bokx, P. K., Pronk, P., van Vlijmen-van Keulen, C. J., Gaastra, M. T. W., Mooij, M. C., Sterk, P. J., Sapelkin, S. V., Dan, V. N., Vetyugova, L. V., Broholm, R., Jensen, L. P., Sillesen, H., Kreiner, S., Bækgaard, N., Qureshi, M. I., McDonald, A., Wing, L., Lim, C. S., Gohel, M., Ellis, M., Franklin, I. J., Davies, A. H., Pierce, I., Kalodiki, E., Lattimer, C., Geroulakos, G., Gatehouse, P. D., Firmin, D. N., Gemayel, G., Christenson, J. T., van den Bos, R. R., Milleret, R., Neumann, M., Nijsten, T., Wiszniewski, A., Szopinski, P., Bilski, R., Proniewski, J., Ratajczak, J., Romera-Villegas, A., Cairols, M. A., Martí-Mestre, X., Riera-Batalla, S., Martinez-Rico, C., Ahmad, A., Saha, P., Rolph, R., Patel, A. S., Modarai, B., Sabharwal, T., Waltham, M., Lauwers, K., Hertoghs, M., van Schil, P., de Maeseneer, M., Rosales, A., Sandbæk, G., Jørgensen, J. J., Uhl, Jean-François, Gillot, Claude, Lawson, J. A., Vuylsteke, M., Th, De Bo, Dompe, G., di Crisci, D., Miquel Abbab, C., Mordon, S., Shepherd, A. C., Gohel, M. S., Brown, L. C., Ragg, J. C., Martel, L., Wolschner, J., Nagy, J., Shadid, N., Nelemans, P., Sommer, A., Lawaetz, M., Rasmussen, L. H., Bjoern, L., Blemings, A., Eklöf, B., Neffendorf, J. E., Soobrah, R., Grewal, P., Gibson, K., Wright, D., Rush, J., Suplick, G., Evans, E., Nelzén, O., Reeder, S. W. I., de Roos, K.-P., Neumann, H. A. M., King, T., Walshe, T. M., Browne, A. M., O'Riordan, C., O'Sullivan, G. J., Pulmonology, and Amsterdam institute for Infection and Immunity

Subjects
General Medicine, Cardiology and Cardiovascular Medicine
Published
2010

3. Is roxithromycin better than amoxicillin in the treatment of acute lower respiratory tract infections in primary care? A double-blind randomized controlled trial

Author

Rm, Hopstaken, Nelemans P, Ee, Stobberingh, Jean Muris, Pe, Rinkens, and Gj, Dinant

Subjects
Adult, Aged, 80 and over, Male, Roxithromycin, Age Factors, Amoxicillin, Penicillins, Pneumonia, Middle Aged, Anti-Bacterial Agents, Logistic Models, Double-Blind Method, Odds Ratio, Humans, Female, Bronchitis, Family Practice, Respiratory Tract Infections, Aged, Netherlands
Abstract

To assess the efficacy of roxithromycin relative to amoxicillin.We conducted a double-blind randomized controlled trial of oral 500 mg amoxicillin 3 times per day vs oral 300 mg roxithromycin once a day for 10 days.We included 196 adults who had presented to a general practitioner with lower respiratory tract infection (LRTI) and, in the physician's opinion, needed antibiotic treatment.We measured clinical response after 10 and 28 days, defined in 4 ways: (1) decrease in LRTI symptoms; (2) complete absence of symptoms; (3) decrease in signs; and (4) complete absence of signs. Self-reported response included the decrease in symptoms and the time until resumption of impaired or abandoned daily activities on days 1 through 10, 21, and 27.Clinical cure rates after the completion of antibiotic treatment (10 days) were not significantly different for the 2 groups. After 28 days, the roxithromycin group showed no increase in cure rate as evidenced by the decrease in symptoms, indicating a significantly lower cure rate. However, this difference did not alter physicians' overall conclusion after complete follow-up that 90% of patients, regardless of age, had been effectively treated with either amoxicillin or roxithromycin.The surplus value of roxithromycin was not confirmed. Amoxicillin remains a reliable first-choice antibiotic in the treatment of LRTI in general practice.

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