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LAY SUMMARY Research has shown time and time again that war has an impact on the mental well-being of Veterans and their families. But what does that impact look like when a mission is characterized by severe violations of norms and values (in other words, moral injury)? In this study, family members of Dutch Veterans talked about the impact on their lives of a mission gone bad in the former Yugoslavia, 25 years after it happened. Although most of the families were doing well, all of the families felt left alone in taking care of their Veterans after they returned and in dealing with negative press coverage. For the well-being of all, they expressed the need for more appreciation for and acknowledgement of Veterans and their families.

What happens to people who are accused of atrocity crimes at the bar of public opinion, are publicly indicted, prosecuted, tried, acquitted of criminal charges and then released? Does the mud stick? Or can the dirt also turn into gold, after legal exoneration and possible compensation? This article seeks to trigger a conversation on the international justice community’s stance on condemnation, compensation and convalescence. Through several versatile histories and stories, it gauges how exonerated persons have been navigating life after acquittal. To what extent have they managed to reverse, or recover from, their previous scandalizations, and if so: how? In thinking about this question, we problematize international justice community protagonists and prosecution services’ modus operandi (and effects) of scandalizing first and prosecuting alleged atrocitaires later. We observe that under the International Criminal Court (ICC)’s current circumstances (operating like a cage in search of birds) more suspects have been scandalized than convicted, but that often the scandal lingers. We conclude that for most acquitted persons requesting post-trial compensation is a dead end, and that doing so for some might further increase reputational damage. While several acquitted people ultimately remained defamed, some exonerated persons fully recovered from the human rights scandal by redefining compensation, and by turning the table and scandalizing the ICC.

Objective: Depression and anxiety cause a high burden of disease and have high relapse rates (39%-72%). This meta-analysis systematically examined effectiveness of relapse prevention strategies on risk of and time to relapse in youth who remitted. Method: PubMed, PsycInfo, Embase, Cochrane, and ERIC databases were searched up to June 15, 2021. Eligible studies compared relapse prevention strategies to control conditions among youth (mean age 13-25 years) who were previously depressed or anxious or with ≥30% improvement in symptoms. Two reviewers independently assessed titles, abstracts, and full texts; extracted study data; and assessed risk of bias and overall strength of evidence. Random-effects models were used to pool results, and mixed-effects models were used for subgroup analyses. Main outcome was relapse rate at last follow-up (PROSPERO ID: CRD42020149326). Results: Of 10 randomized controlled trials (RCTs) that examined depression, 9 were eligible for analysis: 4 included psychological interventions (n = 370), 3 included antidepressants (n = 80), and 2 included combinations (n = 132). No RCTs for anxiety were identified. Over 6 to 75 months, relapse was half as likely following psychological treatment compared with care as usual conditions (k = 6; odds ratio 0.56, 95% CI 0.31 to 1.00). Sensitivity analyses including only studies with ≥50 participants (k = 3), showed similar results. Over 6 to 12 months, relapse was less likely in youth receiving antidepressants compared with youth receiving pill placebo (k = 3; OR 0.29, 95% CI 0.10 to 0.82). Quality of studies was suboptimal. Conclusion: Relapse prevention strategies for youth depression reduce risk of relapse, although adequately powered, high-quality RCTs are needed. This finding, together with the lack of RCTs on anxiety, underscores the need to examine relapse prevention in youth facing these common mental health conditions.

Voice Activity Detection (VAD) is a technique used to identify the presence of human voice in an audio signal. It is implemented as an always-on component in most speech processing applications. As speech is absent most of the time, this component typically dominates the overall average power consumption of the system (excluding microphone). The widespread usage in speech applications and the need for ultra low power VAD have led to a plethora of algorithms and implementations in the hardware domain, necessitating a comprehensive study and analysis to understand (real-time) requirements, different design parameters, testing strategies, but also to identify design trends, challenges and guidelines for future implementations and testing of VAD devices. A scoping review was conducted to identify the articles for hardware implementations of VAD from January 2010 -December 2021, the results of which are presented in this article. The results highlight a big design space being used for VAD along with a lack of standard testing methodology and usage of application-dependent performance metrics. An increased usage of filter-based feature extractors along with neural-network-based classifiers is observed. Due to lack of standardisation, no other trends can be established from the results. A set of rules and guidelines are therefore provided to facilitate the future development and benchmarking of VADs.

In 2014, the European Medicines Agency (EMA) set out requirements for an enhanced safety surveillance for seasonal influenza vaccines. This paper presents data from the yearly Enhanced Passive Safety Surveillance (EPSS) implemented for Influvac® since season 2014/15 and continued for Influvac® Tetra from season 2018/19 onwards.In seven consecutive seasons, an EPSS, aiming for at least 1,000 vaccinees (additional target of 100 vaccinees per five predefined age groups), was conducted in Germany, where market characteristics were expected to allow for a quick generation of representative data. Reactogenicity data in terms of reporting rates, severity and duration of pre-specified local and systemic adverse events of interest (AEI) were collected using response cards, which were completed by vaccinees and returned seven days after vaccination via regular mail. In addition, response cards contained a call center number to enhance reporting of other than pre-specified adverse events.The primary target of at least 1,000 vaccinees was surpassed in all seasons, as was the additional target of 100 adults and elderly. Reactogenicity data were in line with known safety profile of Influvac® and Influvac® Tetra. In children, the target was mostly met in seasons when the EPSS was conducted for Influvac®, but not in seasons when it was conducted for Influvac® Tetra. Although the data for Influvac® Tetra are based on a low number of paediatric vaccinees, they do not indicate a different reactogenicity profile of Influvac® Tetra compared with Influvac®. No signals were identified.The EPSS set up for Influvac® and Influvac® Tetra proved a robust and effective methodology to comply with the objectives of EMÁ's guidance on enhanced safety surveillance of seasonal influenza vaccines. Safety data from seven consecutive seasons confirmed the favourable safety profile of both vaccines.

This article presents a frequency reference system that combines high frequency accuracy and low power consumption using a single-point temperature trim and batch calibration. The system is intended as a low-cost fully integrated crystal oscillator replacement. In this system, the oscillation frequency of a power-efficient, but process, voltage, temperature (PVT) and lifetime (L)-sensitive current-controlled ring oscillator (CCO) is periodically (re)calibrated by the well-behaved frequency stability of an untuned LC –based Colpitts oscillator (LCO), which is optimized for stability over PVT variations and lifetime (PVTL). During the single-point room temperature factory trim, the frequency of the LCO is determined and the result is digitally stored. An on-chip calibration engine tunes the CCO to the target frequency based on the LCO frequency, temperature sensor information, and digitally stored trimming information, thus effectively improving the frequency stability of the ring oscillator. The relatively high-power LCO is heavily duty-cycled to minimize the overall power consumption. A prototype fabricated in a 0.13- μ m CMOS SOI process and assembled in a plastic package demonstrates an inaccuracy lower than ± 93 ppm over a temperature range from − 63 ∘ C to 165 ∘ C across samples. The presented frequency reference system, including on-chip voltage regulators and a temperature sensor, occupies a chip area of 0.69 mm 2 and consumes about 64 μ A from a single 3.3-V supply. The frequency error due to supply variation is roughly 92 ppm/V. The mean frequency shift due to aging, measured before and after a six-day storage bake at 175 ∘ C, is only 52 ppm.

Following the 2021 integrated plastic surgery match, we found a significant increase in home match rates and decrease in match rate for students without a home plastic surgery program with the elimination of visiting sub-internships and the initiation of virtual interviewing. With the return of visiting sub-internships in the 2022 match cycle, we hypothesize that these rates will approach values more consistent with historical controls.Program match data was obtained from posts to residency program Instagram pages and posts associated with the hashtag #PRSMatch2022. Data on visiting sub-internship matches was obtained from a publicly available Google Sheet with applicant contributors. The Chi square test was used to assess for differences.Medical schools and plastic surgery programs were categorized into west, midwest, south, and northeast regions.Matched applicants to integrated plastic surgery residency programs.In total, 192 of 194 (99%) of applicants matched to integrated plastic surgery residency positions were identified. The match rate for applicants without an affiliated plastic surgery program (31.3%) increased from 2021 (p = 0.03) and returned to a level consistent with historical controls (p = 0.38). Similarly, the home program match rate (15.1%) and match rate for applicants from Top 40 medical schools (34.2%) decreased from 2021, returning to pre-pandemic levels (p = 0.63, p = 0.12). Finally, regional match preferences remained generally consistent with historical controls, apart from a higher proportion of northeast applicants matching to programs in the northeast (72.5%, p = 0.04), and a lower proportion of west applicants matching to programs in the west (26.3%, p = 0.002).The 2022 integrated plastic surgery match cycle saw a reversal of many of the changes to match rates seen in the 2021 cycle. These changes may be due to the reintroduction of visiting sub-internships following updates in COVID-19 policies.

In the era of precision measurements of the neutrino oscillation parameters, upcoming neutrino experiments will also be sensitive to physics beyond the Standard Model. KM3NeT/ORCA is a neutrino detector optimised for measuring atmospheric neutrinos from a few GeV to around 100 GeV. In this paper, the sensitivity of the KM3NeT/ORCA detector to neutrino decay has been explored. A three-flavour neutrino oscillation scenario, where the third neutrino mass state $\nu_3$ decays into an invisible state, e.g. a sterile neutrino, is considered. We find that KM3NeT/ORCA would be sensitive to invisible neutrino decays with $1/\alpha_3=\tau_3/m_3 < 180$~$\mathrm{ps/eV}$ at $90\%$ confidence level, assuming true normal ordering. Finally, the impact of neutrino decay on the precision of KM3NeT/ORCA measurements for $\theta_{23}$, $\Delta m^2_{31}$ and mass ordering have been studied. No significant effect of neutrino decay on the sensitivity to these measurements has been found., Comment: 27 pages, 14 figures, bibliography updated, typos corrected

Penicillin-binding proteins (PBPs) make up an essential class of bacterial enzymes that carry out the final steps of peptidoglycan synthesis and regulate the recycling of this polymeric structure. PBPs are an excellent drug target and have been the most clinically relevant antibacterial target since the 1940s with the introduction of β-lactams. Despite this, a large gap in knowledge remains regarding the individual function and regulation of each PBP homologue in most bacteria. This can be attributed to a lack of chemical tools and methods that enable the study of individual PBPs in an activity-dependent manner and in their native environment. The development of such methods in Gram-negative bacteria has been particularly challenging due to the presence of an outer membrane and numerous resistance mechanisms. To address this, we have developed an optimized live-cell assay for screening inhibitors of the PBPs in Escherichia coli MG1655. We utilized EDTA to permeabilize Gram-negative cells, enabling increased penetration of our readout probe, Bocillin-FL, and subsequent analysis of PBP-inhibition profiles. To identify scaffolds for future development of PBP-selective activity-based probes, we screened ten β-lactams, one diazabicyclooctane, and one monobactam for their PBP-selectivity profiles in E. coli MG1655. These results demonstrate the utility of our assay for the screening of inhibitors in live, non-hypersusceptible Gram-negative organisms.

The transmission of antimicrobial resistance (AMR) between food-producing animals (poultry, cattle and pigs) during short journeys ( 8 h) directed to other farms or to the slaughterhouse lairage (directly or with intermediate stops at assembly centres or control posts, mainly transported by road) was assessed. Among the identified risk factors contributing to the probability of transmission of antimicrobial-resistant bacteria (ARB) and antimicrobial resistance genes (ARGs), the ones considered more important are the resistance status (presence of ARB/ARGs) of the animals pre-transport, increased faecal shedding, hygiene of the areas and vehicles, exposure to other animals carrying and/or shedding ARB/ARGs (especially between animals of different AMR loads and/or ARB/ARG types), exposure to contaminated lairage areas and duration of transport. There are nevertheless no data whereby differences between journeys shorter or longer than 8 h can be assessed. Strategies that would reduce the probability of AMR transmission, for all animal categories include minimising the duration of transport, proper cleaning and disinfection, appropriate transport planning, organising the transport in relation to AMR criteria (transport logistics), improving animal health and welfare and/or biosecurity immediately prior to and during transport, ensuring the thermal comfort of the animals and animal segregation. Most of the aforementioned measures have similar validity if applied at lairage, assembly centres and control posts. Data gaps relating to the risk factors and the effectiveness of mitigation measures have been identified, with consequent research needs in both the short and longer term listed. Quantification of the impact of animal transportation compared to the contribution of other stages of the food-production chain, and the interplay of duration with all risk factors on the transmission of ARB/ARGs during transport and journey breaks, were identified as urgent research needs. info:eu-repo/semantics/publishedVersion

Children are an important target group for influenza vaccination, but few studies have prospectively evaluated influenza vaccine efficacy (VE) in children under 3 years of age. This was a randomized Phase III trial to assess the efficacy, immunogenicity, and safety of an inactivated quadrivalent influenza vaccine (QIV) in young children (EudraCT: 2016-004904-74).Influenza-naïve children aged 6-35 months were randomized during three influenza seasons to receive vaccination with QIV or a non-influenza control vaccine. One group of participants was revaccinated with QIV in the subsequent influenza season. The primary efficacy endpoint was the absolute VE of QIV against influenza caused by any circulating strain. Key secondary efficacy endpoints included the absolute VE of QIV against influenza due to antigenically matching strains and immunogenicity. Safety and reactogenicity were also evaluated.In total, 1005 children received QIV and 995 received control vaccine. Influenza A/B infection due to any circulating influenza strain occurred less frequently in children who received QIV versus children receiving a control vaccine. The absolute VE of QIV against any circulating influenza strain was 54% (95% confidence interval [CI]: 37%, 66%). The absolute VE of QIV against antigenically matching influenza strains was 68% (95% CI: 45%, 81%). Mean hemagglutination inhibition titers for all influenza strains in the QIV group increased post-vaccination, whereas increases were minimal in the control vaccine group; results from virus neutralization and neuraminidase-inhibition assays were generally consistent with the hemagglutination inhibition assay findings. Approximately 12 months after primary vaccination with QIV, antibody titers remained higher than pre-vaccination titers for most strains. In participants who were revaccinated, QIV elicited strong antibody responses. The overall safety profile and reactogenicity of QIV was comparable with control vaccine.Primary vaccination with QIV was well tolerated and effective in protecting children aged 6-35 months against influenza.

A novel algorithm is presented that can resolve frequency ambiguity that arises from sampling a set of signals spanning more than a single Nyquist zone. The method uses two samplers, each sampling the same input signal with different (non-integer multiple) sampling rates. The algorithm is able to resolve frequency ambiguity and reconstruct signals with an orthogonal frequency basis spanning multiple Nyquist zones, provided that the aggregate information-bearing bandwidth of the signals is less than half the cumulative data converter sampling rates. This manuscript describes the theoretical background for the algorithm and validates it through measurements performed on a test-board comprising of two 10 bit analog-to-digital converters clocked at two different (non-integer multiple) sample rates. Measurements show that even in the presence of aliasing, an orthogonal signal spanning multiple Nyquist zones can be fully reconstructed.

Antibiotic exposure disturbs the developing infant gut microbiota. The capacity of the gut microbiota to recover from this disturbance (resilience) depends on the type of antibiotic. In this study, infant gut microbiota was exposed to a combination of amoxicillin and clavulanate (amoxicillin/clavulanate) in an in vitro colon model (TIM-2) with fecal-derived microbiota from 1-month-old (1-M; a mixed-taxa community type) as well as 3-month-old (3-M; Bifidobacterium dominated community type) breastfed infants. We investigated the effect of two common infant prebiotics, 2′-fucosyllactose (2’-FL) or galacto-oligosaccharides (GOS), on the resilience of infant gut microbiota to amoxicillin/clavulanate-induced changes in microbiota composition and activity. Amoxicillin/clavulanate treatment decreased alpha diversity and induced a temporary shift of microbiota to a community dominated by enterobacteria. Moreover, antibiotic treatment increased succinate and lactate in both 1- and 3-M colon models, while decreasing the production of short-chain (SCFA) and branched-chain fatty acids (BFCA). The prebiotic effect on the microbiota recovery depended on the fermenting capacity of antibiotic-exposed microbiota. In the 1-M colon model, the supplementation of 2’-FL supported the recovery of microbiota and restored the production of propionate and butyrate. In the 3-M colon model, GOS supplementation supported the recovery of microbiota and increased the production of acetate and butyrate.

Weather and Climate Information Services (WCIS) for agriculture provide weatherand climate forecasts on various timescales, but soil moisture information that is crucial for plantgrowth and optimizing the agricultural yield is still missing. We, therefore, have developed DROPapp, a WCIS with a soil moisture module. This app was designed with and for smallholder farmersworking on rainfed agriculture in northern Ghana and has three main features: 1) information onlocation-specific scientific weather forecasts (SF), 2) local weather forecasts (LF) from smallholderfarmers, and 3) the soil moisture forecasts. The forecasts generate a high probability of raindetection (POD), with a minimum value of 0.7 obtained from LF. The hybrid forecast (HF) thatintegrates the SF and LF yields the highest POD value of 0.9. However, the hybrid system alsohas a high number of false alarms which results in an overall lower forecast performance of HFcompared to SF. More than half of the farmers (58%) perceived that soil moisture forecasts havegood performance. After the implementation of the app, farmers involved in the study were mostlysatisfied with the use and the features of the app. By using the app, they were able to adjust theirfarming activities, such as sowing, planting and weeding dates, fertilizer and herbicide application,and harvesting. Although some limitations exist, the DROP app has potential to be used worldwidein order to deliver actionable knowledge on WCIS for climate-smart farm decision-making.

As contractor and sub-contractor for C3S, SMHI and WU-DES have set up a multi-model operational service for hydrological seasonal forecasts. The service currently produces forecasts of monthly mean river discharge for a pan-European domain using several hydrological models, namely E-HYPEcatch, on irregular catchment delineations, and E-HYPEgrid and VIC-WUR on regular 5km gridded drainage network of EFAS. Also, the EFAS-Lisflood forecasts from the separate ECMWF production line are included in the final data set. All forecasts use the SEAS5 meteorological forecasts with 51 ensemble members. The data from all models are available from the CDS data portal for a re-forecast (https://doi.org/10.24381/cds.13c18212) and a forecast period (https://doi.org/10.24381/cds.52f45864). Further, the most probable forecast is displayed in an online application (https://cds.climate.copernicus.eu/cdsapp#!/software/app-hydrology-seasonal-forecast-explorer?tab=app).Ongoing work is aimed at introducing a second meteorological forecasting system, and adding more output variables at a higher daily temporal resolution. The quality of the forecasts is at this point mainly addressed by working on the input data and statistical downscaling and bias adjustment. The new system is expected to be operational in mid-2024.

[EN] Searches for dark matter (DM) have not provided any solid evidence for the existence of weakly interacting massive particles in the GeV-TeV mass range. Coincidentally, the scale of new physics is being pushed by collider searches well beyond the TeV domain. This situation strongly motivates the exploration of DM masses much larger than a TeV. Secluded scenarios contain a natural way around the unitarity bound on the DM mass, via the early matter domination induced by the mediator of its interactions with the Standard Model. High-energy neutrinos constitute one of the very few direct accesses to energy scales above a few TeV. An indirect search for secluded DM signals has been performed with the ANTARES neutrino telescope using data from 2007 to 2015. Upper limits on the DM annihilation cross section for DM masses up to 6 PeV are presented and discussed, The authors acknowledge the financial support of the funding agencies: Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Commission Européenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), LabEx UnivEarthS (ANR-10-LABX-0023 and ANR-18-IDEX0001), Région Île-de-France (DIM-ACAV), Région Alsace (contrat CPER), Région ProvenceAlpes-Côte d¿Azur, Département du Var and Ville de La Seyne-sur-Mer, France; Bundesministerium für Bildung und Forschung (BMBF), Germany; Istituto Nazionale di Fisica Nucleare (INFN), Italy; Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), The Netherlands; Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI), Romania; Ministerio de Ciencia, Innovación, Investigación y Universidades (MCIU): Programa Estatal de Generación de Conocimiento (refs. PGC2018- 096663-B-C41, -A-C42, -B-C43, -B-C44) (MCIU/FEDER), Generalitat Valenciana: Prometeo (PROMETEO/2020/019), Grisolía (refs. GRISOLIA/2018/119, /2021/192) and GenT (refs. CIDEGENT/2018/034, /2019/043, /2020/049, /2021/023) programs, Junta de Andalucía (ref. A-FQM-053-UGR18), La Caixa Foundation (ref. LCF/BQ/IN17/ 11620019), EU: MSC program (ref. 101025085), Spain; Ministry of Higher Education, Scientific Research and Innovation, Morocco, and the Arab Fund for Economic and Social Development, Kuwait. We also acknowledge the technical support of Ifremer, AIM and Foselev Marine for the sea operation and the CC-IN2P3 for the computing facilities. F. Sala acknowledges funding support from the Initiative Physique des Infinis (IPI), a research training program of the Idex SUPER at Sorbonne Université.

Left atrial (LA) structure and function in heart failure with reduced (HFrEF) versus preserved ejection fraction (HFpEF) is only established in small studies. Therefore, we conducted a systematic review of LA structure and function in order to find differences between patients with HFrEF and HFpEF. English literature on LA structure and function using echocardiography was reviewed to calculate pooled prevalence and weighted mean differences (WMD). A total of 61 studies, comprising 8806 patients with HFrEF and 9928 patients with HFpEF, were included. The pooled prevalence of atrial fibrillation (AF) was 34.4% versus 42.8% in the acute inpatient setting, and 20.1% versus 33.1% in the chronic outpatient setting when comparing between HFrEF and HFpEF. LA volume index (LAVi), LA reservoir global longitudinal strain (LAGLSR), and E/e’ was 59.7 versus 52.7 ml/m2, 9.0% versus 18.9%, and 18.5 versus 14.0 in the acute inpatient setting, and 48.3 versus 38.2 ml/m2, 12.8% versus 23.4%, and 16.9 versus 13.5 in the chronic outpatient setting when comparing HFrEF versus HFpEF, respectively. The relationship between LAVi and LAGLSR was significant in HFpEF, but not in HFrEF. Also, in those studies that directly compared patients with HFrEF versus HFpEF, those with HFrEF had worse LAGLSR [WMD = 16.3% (22.05,8.61); p p

The qualified presumption of safety (QPS) approach was developed to provide a regularly updated generic pre-evaluation of the safety of microorganisms, intended for use in the food or feed chains, to support the work of EFSA's Scientific Panels. The QPS approach is based on an assessment of published data for each agent, with respect to its taxonomic identity, the body of relevant knowledge, safety concerns and occurrence of antimicrobial resistance. Safety concerns identified for a taxonomic unit (TU) are, where possible, confirmed at the species/strain or product level and reflected by ‘qualifications’. In the period covered by this statement, no new information was found that would change the status of previously recommended QPS TUs. Of the 50 microorganisms notified to EFSA in October 2021 to March 2022 (inclusive), 41 were not evaluated: 10 filamentous fungi, 1 Enterococcus faecium, 1 Clostridium butyricum, 3 Escherichia coli and 1 Streptomyces spp. because are excluded from QPS evaluation, and 25 TUs that have already a QPS status. Nine notifications, corresponding to seven TUs were evaluated: four of these, Streptococcus salivarius, Companilactobacillus formosensis, Pseudonocardia autotrophica and Papiliotrema terrestris, being evaluated for the first time. The other three, Microbacterium foliorum, Pseudomonas fluorescens and Ensifer adhaerens were re-assessed. None of these TUs were recommended for QPS status: Ensifer adhaerens, Microbacterium foliorum, Companilactobacillus formosensis and Papiliotrema terrestris due to a limited body of knowledge, Streptococcus salivarius due to its ability to cause bacteraemia and systemic infection that results in a variety of morbidities, Pseudonocardia autotrophica due to lack of body of knowledge and uncertainty on the safety of biologically active compounds which can be produced, and Pseudomonas fluorescens due to possible safety concerns. info:eu-repo/semantics/publishedVersion

Polycyclic aromatic hydrocarbons (PAHs) are intermediates in the formation of soot particles and interstellar grains. However, their formation mechanisms in combustion and interstellar environments are not fully understood. The production of tricyclic PAHs and, in particular, the conversion of a PAH containing a five-membered ring to one with a six-membered ring are of interest to explain PAH abundances in combustion processes. In the present work, resonant ionization mass spectrometry in conjunction with isotopic labeling is used to investigate the formation of the phenalenyl radical from acenaphthylene and methane in an electrical discharge. We show that in this environment the CH cycloaddition mechanism converts a five-membered ring to a six-membered ring. This mechanism can occur in tandem with other PAH formation mechanisms such as hydrogen abstraction/acetylene addition (HACA) to produce larger PAHs in flames and the interstellar medium.

The JFDA applies border control for Salmonella Typhimurium and Salmonella Enteritidis in frozen poultry products. A QMRA model was developed to evaluate the effectiveness of this system in controlling the risk for consumers. The model consists of three modules; consumer phase, risk estimation, and risk reduction. The model inputs were the occurrence of Salmonella in different types of imported poultry products, the LOD of the Rapid'Salmonella, the number of tested samples of each batch, and the criteria for rejection. The model outputs were public health impact as the Minimum Relative Residual Risk (MRRR) given the batches' refusal and the percentage of Batches that are Not-compliant with the Microbiological Criteria (BNMC) of rejection. To estimate the overall MRRR of the border control, the estimated country and product-specific MRRR were summarized and weighted by the total imports of each product from each country. The current border control based on one sample per batch gives an overall MRRR value of 27%. The alternative scenarios based on three and five samples per batch are 12% and 8%, respectively. Overall, the higher the prevalence and/or concentration of Salmonella in imported products, the more the likelihood that batches will be rejected. For products with up-to-date data of occurrence, the estimated BNMC was similar to the observed proportion of rejected batches. The lack of data on the Salmonella concentrations in poultry products from different countries is the major source of the uncertainties in the model. It reduces our opportunities to obtain valid estimates of the absolute risk.

Supplemental material, sj-pdf-5-msj-10.1177_13524585231159817 for Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis by Shira Simon, Ilse M Nauta, Arjan Hillebrand, Menno M Schoonheim, Bernard MJ Uitdehaag, Maureen van Dam, Hanneke E Hulst, Martin Klein, Cornelis J Stam, Brigit A de Jong and Eva MM Strijbis in Multiple Sclerosis Journal

Supplemental material, sj-docx-4-sph-10.1177_19417381231178534 for Sports-Related Health Problems in Para-Sports: A Systematic Review With Quality Assessment by Sietske C.M. Luijten, Leonie M. te Loo, Joske Nauta, Thomas W.J. Janssen, Jasmijn F.M. Holla, René H.J. Otten, Ingrid Vriend and Evert Verhagen in Sports Health

Supplemental material, sj-docx-5-sph-10.1177_19417381231178534 for Sports-Related Health Problems in Para-Sports: A Systematic Review With Quality Assessment by Sietske C.M. Luijten, Leonie M. te Loo, Joske Nauta, Thomas W.J. Janssen, Jasmijn F.M. Holla, René H.J. Otten, Ingrid Vriend and Evert Verhagen in Sports Health

Since 2015 the LIGO and Virgo interferometers have detected gravitational waves from almost one hundred coalescences of compact objects (black holes and neutron stars). This article presents the results of a search performed with data from the ANTARES telescope to identify neutrino counterparts to the gravitational wave sources detected during the third LIGO/Virgo observing run and reported in the catalogues GWTC-2, GWTC-2.1, and GWTC-3. This search is sensitive to all-sky neutrinos of all flavours and of energies $>100$ GeV, thanks to the inclusion of both track-like events (mainly induced by $\nu_\mu$ charged-current interactions) and shower-like events (induced by other interaction types). Neutrinos are selected if they are detected within $\pm 500$ s from the GW merger and with a reconstructed direction compatible with its sky localisation. No significant excess is found for any of the 80 analysed GW events, and upper limits on the neutrino emission are derived. Using the information from the GW catalogues and assuming isotropic emission, upper limits on the total energy $E_{\rm tot, \nu}$ emitted as neutrinos of all flavours and on the ratio $f_\nu = E_{\rm tot, \nu}/E_{\rm GW}$ between neutrino and GW emissions are also computed. Finally, a stacked analysis of all the 72 binary black hole mergers (respectively the 7 neutron star - black hole merger candidates) has been performed to constrain the typical neutrino emission within this population, leading to the limits: $E_{\rm tot, \nu} < 4.0 \times 10^{53}$ erg and $f_\nu < 0.15$ (respectively, $E_{\rm tot, \nu} < 3.2 \times 10^{53}$ erg and $f_\nu < 0.88$) for $E^{-2}$ spectrum and isotropic emission. Other assumptions including softer spectra and non-isotropic scenarios have also been tested., Comment: 13 pages, 4 figures

Supplemental material, sj-pdf-5-msj-10.1177_13524585231159817 for Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis by Shira Simon, Ilse M Nauta, Arjan Hillebrand, Menno M Schoonheim, Bernard MJ Uitdehaag, Maureen van Dam, Hanneke E Hulst, Martin Klein, Cornelis J Stam, Brigit A de Jong and Eva MM Strijbis in Multiple Sclerosis Journal

Supplemental material, sj-docx-4-sph-10.1177_19417381231178534 for Sports-Related Health Problems in Para-Sports: A Systematic Review With Quality Assessment by Sietske C.M. Luijten, Leonie M. te Loo, Joske Nauta, Thomas W.J. Janssen, Jasmijn F.M. Holla, René H.J. Otten, Ingrid Vriend and Evert Verhagen in Sports Health

Supplemental material, sj-docx-3-msj-10.1177_13524585231159817 for Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis by Shira Simon, Ilse M Nauta, Arjan Hillebrand, Menno M Schoonheim, Bernard MJ Uitdehaag, Maureen van Dam, Hanneke E Hulst, Martin Klein, Cornelis J Stam, Brigit A de Jong and Eva MM Strijbis in Multiple Sclerosis Journal

Supplemental material, sj-docx-6-sph-10.1177_19417381231178534 for Sports-Related Health Problems in Para-Sports: A Systematic Review With Quality Assessment by Sietske C.M. Luijten, Leonie M. te Loo, Joske Nauta, Thomas W.J. Janssen, Jasmijn F.M. Holla, René H.J. Otten, Ingrid Vriend and Evert Verhagen in Sports Health

Contains fulltext : 290087.pdf (Publisher’s version ) (Open Access) Background: Cognitive problems, both complaints and objective impairments, are frequent and disabling in patients with multiple sclerosis (MS) and profoundly affect daily living. However, intervention studies that focus on cognitive problems that patients experience in their daily lives are limited. This study therefore aimed to investigate the effectiveness of cognitive rehabilitation therapy (CRT) and mindfulness-based cognitive therapy (MBCT) on patient-reported cognitive complaints in MS. Methods: In this randomized-controlled trial, MS patients with cognitive complaints completed questionnaires and underwent neuropsychological assessments at baseline, post-treatment and 6-month follow-up. Patient-reported cognitive complaints were primarily investigated. Secondary outcomes included personalized cognitive goals and objective cognitive function. CRT and MBCT were compared to enhanced treatment as usual (ETAU) using linear mixed models. Results: Patients were randomized into CRT (n = 37), MBCT (n = 36) or ETAU (n = 37), of whom 100 completed the study. Both CRT and MBCT positively affected patient-reported cognitive complaints compared to ETAU at post-treatment (p

Supplemental material, sj-docx-2-sph-10.1177_19417381231178534 for Sports-Related Health Problems in Para-Sports: A Systematic Review With Quality Assessment by Sietske C.M. Luijten, Leonie M. te Loo, Joske Nauta, Thomas W.J. Janssen, Jasmijn F.M. Holla, René H.J. Otten, Ingrid Vriend and Evert Verhagen in Sports Health

Supplemental material, sj-docx-1-msj-10.1177_13524585231159817 for Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis by Shira Simon, Ilse M Nauta, Arjan Hillebrand, Menno M Schoonheim, Bernard MJ Uitdehaag, Maureen van Dam, Hanneke E Hulst, Martin Klein, Cornelis J Stam, Brigit A de Jong and Eva MM Strijbis in Multiple Sclerosis Journal

Supplemental material, sj-docx-3-sph-10.1177_19417381231178534 for Sports-Related Health Problems in Para-Sports: A Systematic Review With Quality Assessment by Sietske C.M. Luijten, Leonie M. te Loo, Joske Nauta, Thomas W.J. Janssen, Jasmijn F.M. Holla, René H.J. Otten, Ingrid Vriend and Evert Verhagen in Sports Health

Supplemental material, sj-docx-3-sph-10.1177_19417381231178534 for Sports-Related Health Problems in Para-Sports: A Systematic Review With Quality Assessment by Sietske C.M. Luijten, Leonie M. te Loo, Joske Nauta, Thomas W.J. Janssen, Jasmijn F.M. Holla, René H.J. Otten, Ingrid Vriend and Evert Verhagen in Sports Health

Supplemental material, sj-docx-1-sph-10.1177_19417381231178534 for Sports-Related Health Problems in Para-Sports: A Systematic Review With Quality Assessment by Sietske C.M. Luijten, Leonie M. te Loo, Joske Nauta, Thomas W.J. Janssen, Jasmijn F.M. Holla, René H.J. Otten, Ingrid Vriend and Evert Verhagen in Sports Health

Supplemental material, sj-docx-2-sph-10.1177_19417381231178534 for Sports-Related Health Problems in Para-Sports: A Systematic Review With Quality Assessment by Sietske C.M. Luijten, Leonie M. te Loo, Joske Nauta, Thomas W.J. Janssen, Jasmijn F.M. Holla, René H.J. Otten, Ingrid Vriend and Evert Verhagen in Sports Health

Supplemental material, sj-docx-3-msj-10.1177_13524585231159817 for Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis by Shira Simon, Ilse M Nauta, Arjan Hillebrand, Menno M Schoonheim, Bernard MJ Uitdehaag, Maureen van Dam, Hanneke E Hulst, Martin Klein, Cornelis J Stam, Brigit A de Jong and Eva MM Strijbis in Multiple Sclerosis Journal