1. Adult-Onset Still’s Disease Complicated with Haemophagocytic Lymphohistiocytosis (HLH): A Case Report
- Author
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Muhammad Sohaib Asghar, Abubakar Tauseef, Warda Fatmi, Narmin Khan, Maryam Zafar, Uzma Rasheed, Nimra Shaikh, Mohammed Akram, Basmah Fayaz, and Zehra Iqbal
- Subjects
endocrine system ,lcsh:RC633-647.5 ,haemophagocytic lymphohistiocytosis (hlh) ,fungi ,rheumatology ,autoimmune ,lcsh:Diseases of the blood and blood-forming organs ,infectious diseases ,musculoskeletal system ,adult-onset still’s disease ,immunology ,hemic and lymphatic diseases ,haematology ,macrophage activation syndrome ,hormones, hormone substitutes, and hormone antagonists ,connective tissue - Abstract
Haemophagocytic lymphohistiocytosis (HLH) is a rare but potentially aggressive and life-threatening syndrome of overactive histiocytes and lymphocytes that commonly affects infants; it is also observed in children and adults of all ages. The disease is differentiated into either primary or secondary causes. Primary HLH tends to be of genetic origin, while secondary HLH results from either infection, autoimmune disorders, or malignancies. Secondary HLH is most commonly associated with viral infections in immunocompromised patients. This paper presents a case of HLH in a tertiary care hospital, associated with adult-onset Still’s disease, diagnosed on both biochemical criteria and histopathologic examination of bone marrow smear.
- Published
- 2020