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6 results on '"Nagahama H"'

1. BASE - Progress Report 2015

Author

Ulmer, S, Smorra, C, Mooser, A, Sellner, S, Nagahama, H, Higuchi, T, Borchert, M, Schneider, G, Tanaka, T, Blaum, K, Matsuda, Y, Ospelkaus, C, Quint, W, Walz, J, and Yamazaki, Y

Subjects
Physics::Accelerator Physics, High Energy Physics::Experiment, Detectors and Experimental Techniques, Nuclear Experiment
Abstract

The BASE collaboration aims at high-precision comparisons of the fundamental properties of the proton and the antiproton, namely, the magnetic g-factors as well as the charge-to-mass ratios of the particles. This annual report summarizes the achievements made in CERN's 2015 antiproton run.

Published
2016

2. Annual Report 2014 - BASE Collaboration

Author

Ulmer, S, Smorra, C, Mooser, A, Franke, K, Nagahama, H, Higuchi, T, Schneider, G, Van Gorp, S, Blaum, K, Matsuda, Y, Ospelkaus, C, Quint, W, Walz, J, and Yamazaki, Y

Subjects
Physics::Accelerator Physics, Physics::Atomic Physics, Detectors and Experimental Techniques, Nuclear Experiment
Abstract

BASE aims at direct high-precision measurements of the magnetic moments of the proton and the antiproton. This document reports on recent progress of BASE. Highlights are the first direct and most precise measurement of the magnetic moment of a single trapped proton, performed at our experiment at Mainz, as well as trapping and preparation of a single antiproton with the recently built experiment at CERN.

Published
2015

4. Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

Author

Takai, H., Tominaga, K., Motoyama, N., Yoji Andrew Minamishima, Nagahama, H., Tsukiyama, T., Ikeda, K., Nakayama, K., Nakanishi, M., and Nakayama, K. -I

Subjects
G2 Phase, animal structures, Genotype, Immunoblotting, Apoptosis, Mice, Transgenic, environment and public health, Mice, In Situ Nick-End Labeling, Animals, Humans, Alleles, Cells, Cultured, Crosses, Genetic, Cell Nucleus, Mice, Inbred ICR, Models, Genetic, Stem Cells, DNA, Fibroblasts, Embryo, Mammalian, Immunohistochemistry, Mice, Inbred C57BL, enzymes and coenzymes (carbohydrates), Blastocyst, Animals, Newborn, Mutagenesis, embryonic structures, Checkpoint Kinase 1, biological phenomena, cell phenomena, and immunity, Protein Kinases, Cell Division, Research Paper, DNA Damage
Abstract

The recent discovery of checkpoint kinases has suggested the conservation of checkpoint mechanisms between yeast and mammals. In yeast, the protein kinase Chk1 is thought to mediate signaling associated with the DNA damage checkpoint of the cell cycle. However, the function of Chk1 in mammals has remained unknown. Targeted disruption of Chk1 in mice showed that Chk1(-/-) embryos exhibit gross morphologic abnormalities in nuclei as early as the blastocyst stage. In culture, Chk1(-/-) blastocysts showed a severe defect in outgrowth of the inner cell mass and died of apoptosis. DNA replication block and DNA damage failed to arrest the cell cycle before initiation of mitosis in Chk1(-/-) embryos. These results may indicate that Chk1 is indispensable for cell proliferation and survival through maintaining the G(2) checkpoint in mammals.

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