Search

Aims. We produce a clean and well-characterised catalogue of objects within 100 pc of the Sun from the Gaia Early Data Release 3. We characterise the catalogue through comparisons to the full data release, external catalogues, and simulations. We carry out a first analysis of the science that is possible with this sample to demonstrate its potential and best practices for its use., Methods. Theselection of objects within 100 pc from the full catalogue used selected training sets, machine-learning procedures, astrometric quantities, and solution quality indicators to determine a probability that the astrometric solution is reliable. The training set construction exploited the astrometric data, quality flags, and external photometry. For all candidates we calculated distance posterior probability densities using Bayesian procedures and mock catalogues to define priors. Any object with reliable astrometry and a non-zero probability of being within 100 pc is included in the catalogue., Results. We have produced a catalogue of 331 312 objects that we estimate contains at least 92% of stars of stellar type M9 within 100 pc of the Sun. We estimate that 9% of the stars in this catalogue probably lie outside 100 pc, but when the distance probability function is used, a correct treatment of this contamination is possible. We produced luminosity functions with a high signal-to-noise ratio for the main-sequence stars, giants, and white dwarfs. We examined in detail the Hyades cluster, the white dwarf population, and wide-binary systems and produced candidate lists for all three samples. We detected local manifestations of several streams, superclusters, and halo objects, in which we identified 12 members of Gaia Enceladus. We present the first direct parallaxes of five objects in multiple systems within 10 pc of the Sun., Conclusions. We provide the community with a large, well-characterised catalogue of objects in the solar neighbourhood. This is a primary benchmark for measuring and understanding fundamental parameters and descriptive functions in astronomy.

Aims Despite few good-quality studies on the subject, total hip arthroplasty (THA) is increasingly being performed for displaced intracapsular fractures of the neck of femur. We compared outcomes of all patients with displacement of these fractures treated surgically over a ten-year period in one institution. Methods A total of 2,721 patients with intracapsular fractures of the femoral neck treated with either a cemented hemiarthroplasty or a THA at a single centre were retrospectively reviewed. The primary outcomes analyzed were readmission for any reason and revision surgery. We secondarily looked at mortality rates. Results We found no difference in the overall revision rate or rate of infection. However, the rates of readmission due to dislocation, pain, and trochanteric bursitis were significantly higher in the THA group (p = 0.001, p < 0.001, p < 0.001, and p = 0.001, respectively). Conclusion Our study, comparing the outcomes of neck of femur fractures treated with a cemented hemiarthroplasty and THA, revealed the perceived superiority of THA was not borne out by our results. This should be carefully considered before any radical change in practice regarding the use of THA for displaced intracapsular fractures of the femoral neck. Cite this article: Bone Joint J 2020;102-B(6):693–698.

Full list of authors: Gilmore, G.; Randich, S.; Worley, C. C.; Hourihane, A.; Gonneau, A.; Sacco, G. G.; Lewis, J. R.; Magrini, L.; Francois, P.; Jeffries, R. D.; Koposov, S. E.; Bragaglia, A.; Alfaro, E. J.; Allende Prieto, C.; Blomme, R.; Korn, A. J.; Lanzafame, A. C.; Pancino, E.; Recio-Blanco, A.; Smiljanic, R.; Van Eck, S.; Zwitter, T.; Bensby, T.; Flaccomio, E.; Irwin, M. J.; Franciosini, E.; Morbidelli, L.; Damiani, F.; Bonito, R.; Friel, E. D.; Vink, J. S.; Prisinzano, L.; Abbas, U.; Hatzidimitriou, D.; Held, E., V; Jordi, C.; Paunzen, E.; Spagna, A.; Jackson, R. J.; Maiz Apellaniz, J.; Asplund, M.; Bonifacio, P.; Feltzing, S.; Binney, J.; Drew, J.; Ferguson, A. M. N.; Micela, G.; Negueruela, I; Prusti, T.; Rix, H-W; Vallenari, A.; Bergemann, M.; Casey, A. R.; de Laverny, P.; Frasca, A.; Hill, V; Lind, K.; Sbordone, L.; Sousa, S. G.; Adibekyan, V; Caffau, E.; Daflon, S.; Feuillet, D. K.; Gebran, M.; Gonzalez Hernandez, J., I; Guiglion, G.; Herrero, A.; Lobel, A.; Montes, D.; Morel, T.; Ruchti, G.; Soubiran, C.; Tabernero, H. M.; Tautvaisiene, G.; Traven, G.; Valentini, M.; Van der Swaelmen, M.; Villanova, S.; Vazquez, C. Viscasillas; Bayo, A.; Biazzo, K.; Carraro, G.; Edvardsson, B.; Heiter, U.; Jofre, P.; Marconi, G.; Martayan, C.; Masseron, T.; Monaco, L.; Walton, N. A.; Zaggia, S.; Borsen-Koch, V. Aguirre; Alves, J.; Balaguer-Nunez, L.; Barklem, P. S.; Barrado, D.; Bellazzini, M.; Berlanas, S. R.; Binks, A. S.; Bressan, A.; Capuzzo-Dolcetta, R.; Casagrande, L.; Casamiquela, L.; Collins, R. S.; D'Orazi, V; Dantas, M. L. L.; Debattista, V. P.; Delgado-Mena, E.; Di Marcantonio, P.; Drazdauskas, A.; Evans, N. W.; Famaey, B.; Franchini, M.; Fremat, Y.; Fu, X.; Geisler, D.; Gerhard, O.; Solares, E. A. Gonzalez; Grebel, E. K.; Gutierrez Albarran, M. L.; Jimenez-Esteban, F.; Jonsson, H.; Khachaturyants, T.; Kordopatis, G.; Kos, J.; Lagarde, N.; Ludwig, H-G; Mahy, L.; Mapelli, M.; Marfil, E.; Martell, S. L.; Messina, S.; Miglio, A.; Minchev, I; Moitinho, A.; Montalban, J.; Monteiro, M. J. P. F. G.; Morossi, C.; Mowlavi, N.; Mucciarelli, A.; Murphy, D. N. A.; Nardetto, N.; Ortolani, S.; Paletou, F.; Palous, J.; Pickering, J. C.; Quirrenbach, A.; Fiorentin, P. Re; Read, J., I; Romano, D.; Ryde, N.; Sanna, N.; Santos, W.; Seabroke, G. M.; Spina, L.; Steinmetz, M.; Stonkute, E.; Sutorius, E.; Thevenin, F.; Tosi, M.; Tsantaki, M.; Wright, N.; Wyse, R. F. G.; Zoccali, M.; Zorec, J.; Zucker, D. B.-- This is an Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited., Context. The Gaia-ESO Public Spectroscopic Survey is an ambitious project designed to obtain astrophysical parameters and elemental abundances for 100 000 stars, including large representative samples of the stellar populations in the Galaxy, and a well-defined sample of 60 (plus 20 archive) open clusters. We provide internally consistent results calibrated on benchmark stars and star clusters, extending across a very wide range of abundances and ages. This provides a legacy data set of intrinsic value, and equally a large wide-ranging dataset that is of value for the homogenisation of other and future stellar surveys and Gaia's astrophysical parameters. Aims. This article provides an overview of the survey methodology, the scientific aims, and the implementation, including a description of the data processing for the GIRAFFE spectra. A companion paper introduces the survey results. Methods. Gaia-ESO aspires to quantify both random and systematic contributions to measurement uncertainties. Thus, all available spectroscopic analysis techniques are utilised, each spectrum being analysed by up to several different analysis pipelines, with considerable effort being made to homogenise and calibrate the resulting parameters. We describe here the sequence of activities up to delivery of processed data products to the ESO Science Archive Facility for open use. Results. The Gaia-ESO Survey obtained 202 000 spectra of 115 000 stars using 340 allocated VLT nights between December 2011 and January 2018 from GIRAFFE and UVES. © G. Gilmore et al. 2022. Conclusions. The full consistently reduced final data set of spectra was released through the ESO Science Archive Facility in late 2020, with the full astrophysical parameters sets following in 2022. A companion article reviews the survey implementation, scientific highlights, the open cluster survey, and data products., Based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under programme ID 188.B-3002. These data products have been processed by the Cambridge Astronomy Survey Unit (CASU) at the Institute of Astronomy, University of Cambridge, and by the FLAMES/UVES reduction team at INAF/Osservatorio Astrofisico di Arcetri. Public access to the data products is via the ESO SAF, and the Gaia-ESO Survey Data Archive, prepared and hosted by the Wide Field Astronomy Unit, Institute for Astronomy, University of Edinburgh, which is funded by the UK Science and Technology Facilities Council. This work was partly supported by the European Union FP7 programme through ERC grant number 320360 and by the Leverhulme Trust through grant RPG-2012-541. We acknowledge the support from INAF and Ministero dell’ Istruzione, dell’ Università’ e della Ricerca (MIUR) in the form of the grant “Premiale VLT 2012”. The project presented here benefited in development from discussions held during the Gaia-ESO workshops and conferences supported by the ESF (European Science Foundation) through the GREAT Research Network Programme. This research has made use of the SIMBAD database, operated at CDS, Strasbourg, France. R.S. acknowledges support from the National Science Centre, Poland (2014/15/B/ST9/03981). This work was partly supported by the INAF grant for mainstream projects: “Enhancing the legacy of the Gaia-ESO Survey for open cluster science”. F.J.E. acknowledges financial support from the Spanish MINECO/FEDER through the grant AYA2017-84089 and MDM-2017-0737 at Centro de Astrobiología (CSIC-INTA), Unidad de Excelencia María de Maeztu, and from the European Union’s Horizon 2020 research and innovation programme under Grant Agreement no. 824064 through the ESCAPE – the European Science Cluster of Astronomy and Particle Physics ESFRI Research Infrastructures project. T.B. was funded by the “The New Milky Way” project grant from the Knut and Alice Wallenberg Foundation. S.R.B. acknowledges support by the Spanish Government under grants AYA2015-68012-C2-2-P and PGC2018-093741-B-C21/C22 (MICIU/AEI/FEDER, UE). W.J.S. acknowledges CAPES for a PhD studentship. J.M.A. acknowledges support from the Spanish Government Ministerio de Ciencia e Innovación through grants AYA2013-40611-P, AYA2016-75931-C2-2-P, and PGC2018-095049-B-C22. T.M. and others from STAR institute, Liege, Belgium are grateful to Belgian F.R.S.-FNRS for support, and are also indebted for an ESA/PRODEX Belspo contract related to the Gaia Data Processing and Analysis Consortium and for support through an ARC grant for Concerted Research Actions financed by the Federation Wallonie-Brussels.. This research has been partially supported by the following grants: MIUR Premiale “Gaia-ESO survey” (PI S. Randich), MIUR Premiale “MiTiC: Mining the Cosmos” (PI B. Garilli), the ASI-INAF contract 2014-049-R.O: “Realizzazione attività tecniche/scientifiche presso ASDC” (PI Angelo Antonelli), Fondazione Cassa di Risparmio di Firenze, progetto: “Know the star, know the planet” (PI E. Pancino), and Progetto Main Stream INAF: “Chemo-dynamics of globular clusters: the Gaia revolution” (PI E. Pancino). V.A. acknowledges the support from Fundação para a Ciência e Tecnologia (FCT) through Investigador FCT contract nr. IF/00650/2015/CP1273/CT0001. A.J.K. acknowledges support by the Swedish National Space Agency (SNSA). A.B. acknowledges support by ANID, – Millennium Science Initiative Program – NCN19_171, and FONDECYT regular 1190748. E.M. acknowledges financial support from the Spanish State Research Agency (AEI) through project MDM-2017-0737 Unidad de Excelencia “María de Maeztu” – Centro de Astrobiología (CSIC-INTA). T.Z. acknowledges financial support of the Slovenian Research Agency (research core funding no. P1-0188) and the European Space Agency (Prodex Experiment Arrangement No. C4000127986). P.J. acknowledges support FONDECYT Regular 1200703. The work of I.N. is partially supported by the Spanish Government Ministerio de Ciencia, Innovación y Universidades under grant PGC2018-093741-B-C21 (MICIU/AEI/FEDER, UE). Funding for this work has been provided by the ARC Future Fellowship FT160100402. C.A.P. acknowledges financial support from the Spanish Government through research grants MINECO AYA 2014-56359-P, MINECO AYA2017-86389-P, and MICINN PID2020-117493GB-I00. S.F. was supported by the grants 2011-5042 and 2016-03412 from the Swedish Research Council and the project grant “The New Milky Way” from the Knut and Alice Wallenberg Foundation. C.A.S.U. is supported through STFC grants: ST/H004157/1, ST/J00541X/1, ST/M007626/1, ST/N005805/1, ST/T003081/1. Work reported here benefited from support through the GREAT-ITN FP7 project Grant agreement ID: 264895. D.K.F. acknowledges funds from the Alexander von Humboldt Foundation in the framework of the Sofja Kovalevskaja Award endowed by the Federal Ministry of Education and Research and the grant 2016-03412 from the Swedish Research Council. A.H. acknowledges support from the Spanish Government Ministerio de Ciencia e Innovación and ERD Funds through grants PGC-2018-091 3741-B-C22 and CEX2019-000920-S. X.F. acknowledges the support of China Postdoctoral Science Foundation 2020M670023. M.L.L.D. acknowledges the Polish NCN grant number 2019/34/E/ST9/00133. Part of this work was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – Project-ID 138713538 – SFB 881 (“The Milky Way System”, subproject A09). M.Z. acknowledges support from the National Agency for Research and Development (ANID) grants: FONDECYT Regular 1191505, Millennium Institute of Astrophysics ICN12-009, BASAL Center for Astrophysics and Associated Technologies AFB-170002. R.B. acknowledges support from the project PRIN-INAF 2019 “Spectroscopically Tracing the Disk Dispersal Evolution”. H.M.T. acknowledges financial support from the Agencia Estatal de Investigación of the Ministerio de Ciencia, Innovación y Universidades through projects PID2019-109522GB-C51,54/AEI/10.13039/501100011033, and the Centre of Excellence “María de Maeztu” award to Centro de Astrobiología (MDM-2017-0737). J.I.G.H. acknowledges financial support from the Spanish Ministry of Science and Innovation (MICINN) project AYA2017-86389-P, and also from the Spanish MICINN under 2013 Ramѳn y Cajal program RYC-2013-14875. V.P.D. is supported by STFC Consolidated grant ST/R000786/1. N.L. acknowledges financial support from “Programme National de Physique Stellaire” (PNPS) and the “Programme National Cosmology et Galaxies (PNCG)” of CNRS/INSU, France. A.R.C. is supported in part by the Australian Research Council through a Discovery Early Career Researcher Award (DE190100656). Parts of this research were supported by the Australian Research Council Centre of Excellence for All Sky Astrophysics in 3 Dimensions (ASTRO 3D), through project number CE170100013. P.S.B. is supported by the Swedish Research Council through individual project grants with contract Nos. 2016-03765 and 2020-03404. A.M. acknowledges funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 772293 – project ASTEROCHRONOMETRY). J.P. was supported by the project RVO: 67985815. E.D.M. acknowledges the support from FCT through the research grants UIDB/04434/2020 & UIDP/04434/2020 and through Investigador FCT contract IF/00849/2015/CP1273/CT0003. This work was (partially) supported by the Spanish Ministry of Science, Innovation and University (MICIU/FEDER, UE) through grant RTI2018-095076-B-C21, and the Institute of Cosmos Sciences University of Barcelona (ICCUB, Unidad de Excelencia 'María de Maeztu’) through grant CEX2019-000918-M. S.L.M. acknowledges the support of the UNSW Scientia Fellowship program and the Australian Research Council through Discovery Project grant DP180101791. GT acknowledges financial support of the Slovenian Research Agency (research core funding No. P1-0188) and the European Space Agency (Prodex Experiment Arrangement No. C4000127986). S.G.S acknowledges the support from FCT through Investigador FCT contract nr. CEECIND/00826/2018 and POPH/FSE (EC). H.G.L. acknowledges financial support by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – Project-ID 138713538 – SFB 881 (“The Milky Way System”, subproject A04). This work was (partially) supported by the Spanish Ministry of Science, Innovation and University (MICIU/FEDER, UE) through grant RTI2018-095076-B-C21, and the Institute of Cosmos Sciences University of Barcelona (ICCUB, Unidad de Excelencia ’María de Maeztu’) through grant CEX2019-000918-M. T.K. is supported by STFC Consolidated grant ST/R000786/1. M.V. acknowledges the support of the Deutsche Forschungsgemeinschaft (DFG, project number: 428473034). T.M. is supported by a grant from the Fondation ULB. We acknowledge financial support from the Universidad Complutense de Madrid (UCM) and by the Spanish Ministerio de Ciencia, Innovación y Universidades, Ministerio de Economía y Competitividad, from project AYA2016-79425-C3-1-P and PID2019-109522GB-C5[4]/AEI/10.13039/501100011033. U.H. acknowledges support from the Swedish National Space Agency (SNSA/Rymdstyrelsen). D.G. gratefully acknowledges support from the Chilean Centro de Excelencia en Astrofísica y Tecnologías Afines (CATA) BASAL grant AFB-170002. D.G. also acknowledges financial support from the Dirección de Investigación y Desarrollo de la Universidad de La Serena through the Programa de Incentivo a la Investigación de Académicos (PIA-DIDULS). A. Lobel acknowledges support in part by the Belgian Federal Science Policy Office under contract No. BR/143/A2/BRASS. We acknowledge financial support from the Universidad Complutense de Madrid (UCM) and by the Spanish Ministerio de Ciencia, Innovación y Universidades, Ministerio de Economía y Competitividad, from project AYA2016-79425-C3-1-P and PID2019-109522GB-C5[4]/AEI/10.13039/501100011033. A.M. acknowledges the support from the Portuguese Fundação para a Ciência e a Tecnologia (FCT) through the Portuguese Strategic Programme UID/FIS/00099/2019 for CENTRA. T.M. acknowledges financial support from the Spanish Ministry of Science and Innovation (MICINN) through the Spanish State Research Agency, under the Severo Ochoa Program 2020-2023 (CEX2019-000920-S). E.J.A. acknowledges funding from the State Agency for Research of the Spanish MCIU through the “Center of Excellence Severo Ochoa” award to the Instituto de Astrofísica de An- dalucía (SEV-2017-0709).

Even among the most irradiated gas giants, so-called ultra-hot Jupiters, KELT-9b stands out as the hottest planet thus far discovered with a dayside temperature of over 4500K. At these extreme irradiation levels, we expect an increase in heat redistribution efficiency and a low Bond albedo owed to an extended atmosphere with molecular hydrogen dissociation occurring on the planetary dayside. We present new photometric observations of the KELT-9 system throughout 4 full orbits and 9 separate occultations obtained by the 30cm space telescope CHEOPS. The CHEOPS bandpass, located at optical wavelengths, captures the peak of the thermal emission spectrum of KELT-9b. In this work we simultaneously analyse CHEOPS phase curves along with public phase curves from TESS and Spitzer to infer joint constraints on the phase curve variation, gravity-darkened transits, and occultation depth in three bandpasses, as well as derive 2D temperature maps of the atmosphere at three different depths. We find a day-night heat redistribution efficiency of $\sim$0.3 which confirms expectations of enhanced energy transfer to the planetary nightside due to dissociation and recombination of molecular hydrogen. We also calculate a Bond albedo consistent with zero. We find no evidence of variability of the brightness temperature of the planet, excluding variability greater than 1% (1$\sigma$)., Comment: 21 pages, 9 figures, accepted for publication in A&A

Full list of authors: Hodgkin, S. T.; Harrison, D. L.; Breedt, E.; Wevers, T.; Rixon, G.; Delgado, A.; Yoldas, A.; Kostrzewa-Rutkowska, Z.; Wyrzykowski, Ł.; van Leeuwen, M.; Blagorodnova, N.; Campbell, H.; Eappachen, D.; Fraser, M.; Ihanec, N.; Koposov, S. E.; Kruszyńska, K.; Marton, G.; Rybicki, K. A.; Brown, A. G. A.; Burgess, P. W.; Busso, G.; Cowell, S.; De Angeli, F.; Diener, C.; Evans, D. W.; Gilmore, G.; Holland, G.; Jonker, P. G.; van Leeuwen, F.; Mignard, F.; Osborne, P. J.; Portell, J.; Prusti, T.; Richards, P. J.; Riello, M.; Seabroke, G. M.; Walton, N. A.; Ábrahám, P.; Altavilla, G.; Baker, S. G.; Bastian, U.; O'Brien, P.; de Bruijne, J.; Butterley, T.; Carrasco, J. M.; Castañeda, J.; Clark, J. S.; Clementini, G.; Copperwheat, C. M.; Cropper, M.; Damljanovic, G.; Davidson, M.; Davis, C. J.; Dennefeld, M.; Dhillon, V. S.; Dolding, C.; Dominik, M.; Esquej, P.; Eyer, L.; Fabricius, C.; Fridman, M.; Froebrich, D.; Garralda, N.; Gomboc, A.; González-Vidal, J. J.; Guerra, R.; Hambly, N. C.; Hardy, L. K.; Holl, B.; Hourihane, A.; Japelj, J.; Kann, D. A.; Kiss, C.; Knigge, C.; Kolb, U.; Komossa, S.; Kóspál, Á.; Kovács, G.; Kun, M.; Leto, G.; Lewis, F.; Littlefair, S. P.; Mahabal, A. A.; Mundell, C. G.; Nagy, Z.; Padeletti, D.; Palaversa, L.; Pigulski, A.; Pretorius, M. L.; van Reeven, W.; Ribeiro, V. A. R. M.; Roelens, M.; Rowell, N.; Schartel, N.; Scholz, A.; Schwope, A.; Sipőcz, B. M.; Smartt, S. J.; Smith, M. D.; Serraller, I.; Steeghs, D.; Sullivan, M.; Szabados, L.; Szegedi-Elek, E.; Tisserand, P.; Tomasella, L.; van Velzen, S.; Whitelock, P. A.; Wilson, R. W.; Young, D. R.-- This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited., Context. Since July 2014, the Gaia mission has been engaged in a high-spatial-resolution, time-resolved, precise, accurate astrometric, and photometric survey of the entire sky. Aims. We present the Gaia Science Alerts project, which has been in operation since 1 June 2016. We describe the system which has been developed to enable the discovery and publication of transient photometric events as seen by Gaia. Methods. We outline the data handling, timings, and performances, and we describe the transient detection algorithms and filtering procedures needed to manage the high false alarm rate. We identify two classes of events: (1) sources which are new to Gaia and (2) Gaia sources which have undergone a significant brightening or fading. Validation of the Gaia transit astrometry and photometry was performed, followed by testing of the source environment to minimise contamination from Solar System objects, bright stars, and fainter near-neighbours. Results. We show that the Gaia Science Alerts project suffers from very low contamination, that is there are very few false-positives. We find that the external completeness for supernovae, CE = 0.46, is dominated by the Gaia scanning law and the requirement of detections from both fields-of-view. Where we have two or more scans the internal completeness is CI = 0.79 at 3 arcsec or larger from the centres of galaxies, but it drops closer in, especially within 1 arcsec. Conclusions. The per-Transit photometry for Gaia transients is precise to 1% at G = 13, and 3% at G = 19. The per-Transit astrometry is accurate to 55 mas when compared to Gaia DR2. The Gaia Science Alerts project is one of the most homogeneous and productive transient surveys in operation, and it is the only survey which covers the whole sky at high spatial resolution (subarcsecond), including the Galactic plane and bulge. © S. T. Hodgkin et al. 2021., This work has made use of data from the European Space Agency (ESA) mission Gaia (https://www.cosmos.esa.int/gaia), processed by the Gaia Data Processing and Analysis Consortium (DPAC, https://www.cosmos.esa.int/web/gaia/dpac/consortium). Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement. Further details of funding authorities and individuals contributing to the success of the mission is shown at https://gea.esac.esa.int/archive/documentation/GEDR3/Miscellaneous/sec_acknowl/. We thank the United Kingdom Particle Physics and Astronomy Research Council (PPARC), the United Kingdom Science and Technology Facilities Council (STFC), and the United Kingdom Space Agency (UKSA) through the following grants to the University of Bristol, the University of Cambridge, the University of Edinburgh, the University of Leicester, the Mullard Space Sciences Laboratory of University College London, and the United Kingdom Rutherford Appleton Laboratory (RAL): PP/D006511/1, PP/D006546/1, PP/D006570/1, ST/I000852/1, ST/J005045/1, ST/K00056X/1, ST/K000209/1, ST/K000756/1, ST/L006561/1, ST/N000595/1, ST/S000623/1, ST/N000641/1, ST/N000978/1, ST/N001117/1, ST/S000089/1, ST/S000976/1, ST/S001123/1, ST/S001948/1, ST/S002103/1, and ST/V000969/1. This paper made use of the Whole Sky Database (WSDB) created by Sergey Koposov and maintained at the Institute of Astronomy, Cambridge with financial support from the Science and Technology Facilities Council (STFC) and the European Research Council (ERC). We thank the William Herschel and Isaac Newton Telescopes on the Roque de los Muchachos Observatory, La Palma, Spain, as well as the Optical Infrared Coordination Network for Astronomy (OPTICON) for their support of this project through telescope time, especially during the commissioning and verification phases. We thank the Copernico 1.82 m telescope (Mt. Ekar, Asiago Italy) operated by INAF Padova for supporting the project through telescope time (under the Large Programme Tomasella-SNe) during the verification phases. We acknowledge observations taken as part of the PESSTO project collected at the European Organisation for Astronomical Research in the Southern Hemisphere under ESO programme 199.D-0143. Authors at the ICCUB were supported by the Spanish Ministry of Science, Innovation and University (MICIU/FEDER, UE) through grant RTI2018-095076-B-C21, and the Institute of Cosmos Sciences University of Barcelona (ICCUB, Unidad de Excelencia ’María de Maeztu’) through grant CEX2019-000918-M. This work is supported by Polish NCN grants: Daina No. 2017/27/L/ST9/03221, Harmonia No. 2018/30/M/ST9/00311, Preludium No. 2017/25/N/ST9/01253 and MNiSW grant DIR/WK/2018/12 as well as the European Commission’s Horizon2020 OPTICON grant No. 730890. The Authors would like to thank the Warsaw University OGLE project for their continuous support in this work. AB acknowledges financial support from the Netherlands Research School for Astronomy (NOVA). AG acknowledges the financial support from the Slovenian Research Agency (grants P1-0031, I0-0033, J1-8136, J1-2460). AH was funded in part by the Leverhulme Trust through grant RPG-2012-541 and by the European Research Council grant 320360. AP acknowledges support from the NCN grant no. 2016/21/B/ST9/01126. CM acknowledges support from Jim and Hiroko Sherwin. DAK acknowledges support from the Spanish research projects AYA 2014-58381-P, AYA2017-89384-P, from Juan de la Cierva Incorporación fellowship IJCI-2015-26153, and from Spanish National Research Project RTI2018-098104-J-I00 (GRBPhot). EB and STH are funded by the Science and Technology Facilities Council grant ST/S000623/1. TW was funded in part by European Research Council grant 320360 and by European Commission grant 730980. GC acknowledges the Agenzia Spaziale Italiana (ASI) for its continuing support through contract 2018-24-HH.0 to the Italian Istituto Nazionale di Astrofisica (INAF). GD acknowledges the observing grant support from the Institute of Astronomy and Rozhen NAO BAS through the bilateral joint research project “Gaia Celestial Reference Frame (CRF) and fast variable astronomical objects” (during 2020-2022, leader is G. Damljanovic), and support by the Ministry of Education, Science and Technological Development of the Republic of Serbia (contract no. 451-03-68/2020-14/200002). G. Marton acknowledges support from the EC Horizon 2020 project OPTICON (730890) and the ESA PRODEX contract no. 4000129910. MF is supported by a Royal Society - Science Foundation Ireland University Research Fellowship NB acknowledges support from the research programme VENI, with project number 016.192.277, which is (partly) financed by the Netherlands Organisation for Scientific Research (NWO). NI is partially supported by Polish NCN DAINA grant no. 2017/27/L/ST9/03221. PAW acknowledges research funding from the South African National Research Foundation. RWW was funded by the Science and Technology Facilities Council grant ST/P000541/1. V.A.R.M.R. acknowledges financial support from Radboud Excellence Initiative, the Fundação para a Ciência e a Tecnologia (FCT) in the form of an exploratory project of reference IF/00498/2015/CP1302/CT0001, FCT and the Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through national funds and when applicable co-funded EU funds under the project UIDB/EEA/50008/2020, and supported by Enabling Green E-science for the Square Kilometre Array Research Infrastructure (ENGAGE-SKA), POCI-01-0145-FEDER-022217, and PHOBOS, POCI-01-0145-FEDER-029932, funded by Programa Operacional Competitividade e Internacionalização (COMPETE 2020) and FCT, Portugal. ZKR acknowledges funding from the Netherlands Research School for Astronomy (NOVA). ZN acknowledges support from the ESA PRODEX contract nr. 4000129910., With funding from the Spanish government through the Severo Ochoa Centre of Excellence accreditation SEV-2017-0709.

Aims. We aim to demonstrate the scientific potential of the Gaia Early Data Release 3 (EDR3) for the study of different aspects of the Milky Way structure and evolution and we provide, at the same time, a description of several practical aspects of the data and examples of their usage., Methods. We used astrometric positions, proper motions, parallaxes, and photometry from EDR3 to select different populations and components and to calculate the distances and velocities in the direction of the anticentre. In this direction, the Gaia astrometric data alone enable the calculation of the vertical and azimuthal velocities; also, the extinction is relatively low compared to other directions in the Galactic plane. We then explore the disturbances of the current disc, the spatial and kinematical distributions of early accreted versus in situ stars, the structures in the outer parts of the disc, and the orbits of open clusters Berkeley 29 and Saurer 1., Results. With the improved astrometry and photometry of EDR3, we find that: (i) the dynamics of the Galactic disc are very complex with oscillations in the median rotation and vertical velocities as a function of radius, vertical asymmetries, and new correlations, including a bimodality with disc stars with large angular momentum moving vertically upwards from below the plane, and disc stars with slightly lower angular momentum moving preferentially downwards; (ii) we resolve the kinematic substructure (diagonal ridges) in the outer parts of the disc for the first time; (iii) the red sequence that has been associated with the proto-Galactic disc that was present at the time of the merger with Gaia-Enceladus-Sausage is currently radially concentrated up to around 14 kpc, while the blue sequence that has been associated with debris of the satellite extends beyond that; (iv) there are density structures in the outer disc, both above and below the plane, most probably related to Monoceros, the Anticentre Stream, and TriAnd, for which the Gaia data allow an exhaustive selection of candidate member stars and dynamical study; and (v) the open clusters Berkeley 29 and Saurer 1, despite being located at large distances from the Galactic centre, are on nearly circular disc-like orbits., Conclusions. Even with our simple preliminary exploration of the Gaia EDR3, we demonstrate how, once again, these data from the European Space Agency are crucial for our understanding of the different pieces of our Galaxy and their connection to its global structure and history.

We thank the anonymous referee for comments that improved the manuscript. The authors thank the Belgian Federal Science Policy Office (BELSPO) for the provision of financial support in the framework of the PRODEX Programme of the European Space Agency (ESA) under contract number PEA 4000131343. This work has been supported by the University of Liege through an ARC grant for Concerted Research Actions financed by the Wallonia-Brussels Federation. The authors acknowledge support from the Swiss NCCR PlanetS and the Swiss National Science Foundation. V.V.G. is a F.R.S.-FNRS Research Associate. M.G. is an F.R.S.-FNRS Senior Research Associate. St.C. acknowledges financial support from the Centre National d'Etudes Spatiales (CNES, France) and from the Agence Nationale de la Recherche (ANR, France) under grant ANR-17-CE31-0018. K.G.I. is the ESA CHEOPS Project Scientist and is responsible for the ESA CHEOPS Guest Observers Programme. She does not participate in, or contribute to, the definition of the Guaranteed Time Programme of the CHEOPS mission through which observations described in this paper have been taken, nor to any aspect of target selection for the programme. D.E. has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (project FOUR ACES; grant agreement No 724427). This project has been carried out in the frame of the National Centre for Competence in Research PlanetS supported by the Swiss National Science Foundation (SNSF). G.B. acknowledges support from CHEOPS ASI-INAF agreement n. 2019-29-HH.0. A.J.M. acknowledges funding from the Swedish Research Council (starting grant 2017-04945) and the Swedish National Space Agency (career grant 120/19C). A.C.C. and T.G.W. acknowledge support from STFC consolidated grant number ST/M001296/1. A.B. was supported by the SNSA. M.F. gratefully acknowledge the support of the Swedish National Space Agency (DNR 65/19, 174/18). S.H. acknowledges CNES funding through the grant 837319. S.C.C.B. acknowledges support from FCT through FCT contracts nr. IF/01312/2014/CP1215/CT0004. S.G.S. acknowledge support from FCT through FCT contract nr. CEECIND/00826/2018 and POPH/FSE (EC). This work was supported by FCT -Fundacao para a Ciencia e a Tecnologia through national funds and by FEDER through COMPETE2020 -Programa Operacional Competitividade e Internacionalizacao by these grants: UID/FIS/04434/2019; UIDB/04434/2020; UIDP/04434/2020; PTDC/FIS-AST/32113/2017 & POCI-01-0145-FEDER032113; PTDC/FIS-AST/28953/2017 & POCI-01-0145-FEDER-028953; PTDC/FIS-AST/28987/2017 & POCI-01-0145-FEDER-028987. O.D.S.D. is supported in the form of work contract (DL 57/2016/CP1364/CT0004) funded by national funds through FCT. B.-O.D. acknowledges support from the Swiss National Science Foundation (PP00P2-190080). B.N.B. acknowledges funding through the TESS Guest Investigator Program Grant 80NSSC21K0364. We acknowledge support from the Spanish Ministry of Science and Innovation and the European Regional Development Fund through grants ESP2016-80435-C2-1-R, ESP2016-80435-C2-2-R, PGC2018-098153-B-C33, PGC2018-098153-B-C31, ESP2017-87676-C5-1-R, MDM-2017-0737 Unidad de Excelencia "Maria de Maeztu"-Centro de Astrobiologia (INTA-CSIC), as well as the support of the Generalitat de Catalunya/CERCA programme. The MOC activities have been supported by the ESA contract No. 4000124370. I.R. acknowledges support from the Spanish Ministry of Science and Innovation and the European Regional Development Fund through grant PGC2018-098153-BC33, as well as the support of the Generalitat de Catalunya/CERCA programme. X.B., Se.C., D.G., M.F. and J.L. acknowledge their role as ESA-appointed CHEOPS science team members. D.G. gratefully acknowledges financial support from the CRT foundation under Grant No. 2018.2323 "Gaseous or rocky? Unveiling the nature of small worlds". P.F.L.M. acknowledges support from STFC research grant number ST/M001040/1. This project has been supported by the Hungarian National Research, Development and Innovation Office (NKFIH) grants GINOP-2.3.2-15-2016-00003, K-119517, K-125015, and the City of Szombathely under Agreement No. 67.177-21/2016. This paper includes data collected by the TESS mission. Funding for the TESS mission is provided by the NASA Explorer Program. Funding for the TESS Asteroseismic Science Operations Centre is provided by the Danish National Research Foundation (Grant agreement no.: DNRF106), ESA PRODEX (PEA 4000119301) and Stellar Astrophysics Centre (SAC) at Aarhus University. We thank the TESS team and staff and TASC/TASOC for their support of the present work. This work has made use of data from the ESA mission Gaia (https://www.cosmos.esa.int/gaia), processed by the Gaia Data Processing and Analysis Consortium (DPAC, https://www.cosmos.esa.int/web/gaia/dpac/consortium).Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement., Context. Hot subdwarfs experienced strong mass loss on the red giant branch (RGB) and are now hot and small He-burning objects. These stars constitute excellent opportunities for addressing the question of the evolution of exoplanetary systems directly after the RGB phase of evolution. Aims. In this project we aim to perform a transit survey in all available light curves of hot subdwarfs from space-based telescopes (Kepler, K2, TESS, and CHEOPS) with our custom-made pipeline SHERLOCK in order to determine the occurrence rate of planets around these stars as a function of orbital period and planetary radius. We also aim to determine whether planets that were previously engulfed in the envelope of their red giant host star can survive, even partially, as a planetary remnant. Methods. For this first paper, we performed injection-and-recovery tests of synthetic transits for a selection of representative Kepler, K2, and TESS light curves to determine which transiting bodies in terms of object radius and orbital period we will be able to detect with our tools. We also provide estimates for CHEOPS data, which we analyzed with the pycheops package. Results. Transiting objects with a radius less than or similar to 1.0 R-circle times can be detected in most of the Kepler, K2, and CHEOPS targets for the shortest orbital periods (1 d and shorter), reaching values as low as similar to 0.3 R-circle times in the best cases. Sub-Earth-sized bodies are only reached for the brightest TESS targets and for those that were observed in a significant number of sectors. We also give a series of representative results for larger planets at greater distances, which strongly depend on the target magnitude and on the length and quality of the data. Conclusions. The TESS sample will provide the most important statistics for the global aim of measuring the planet occurrence rate around hot subdwarfs. The Kepler, K2, and CHEOPS data will allow us to search for planetary remnants, that is, very close and small (possibly disintegrating) objects., European Space Agency European Commission PEA 4000131343, University of Liege through an ARC grant for Concerted Research Actions - Wallonia-Brussels Federation, Swiss NCCR PlanetS, Swiss National Science Foundation (SNSF) European Commission, Centre National D'etudes Spatiales, French National Research Agency (ANR) ANR-17-CE31-0018, European Research Council (ERC) 724427, Swiss National Science Foundation (SNSF), CHEOPS ASI-INAF 2019-29-HH.0, Swedish Research Council European Commission 2017-04945, Swedish National Space Agency 120/19C - DNR 65/19 - 174/18, UK Research & Innovation (UKRI) Science & Technology Facilities Council (STFC) ST/M001296/1- ST/M001040/1, SNSA, Centre National D'etudes Spatiales 837319, European Commission European Commission Joint Research Centre European Social Fund (ESF), Portuguese Foundation for Science and Technology DL 57/2016/CP1364/CT0004 - IF/01312/2014/CP1215/CT0004 - CEECIND/00826/2018, European Commission UID/FIS/04434/2019 - UIDB/04434/2020 - UIDP/04434/2020 - PTDC/FIS-AST/32113/2017 - POCI-01-0145-FEDER032113 - PTDC/FIS-AST/28953/2017 - POCI-01-0145-FEDER-028953 - PTDC/FIS-AST/28987/2017 - POCI-01-0145-FEDER-028987, Swiss National Science Foundation (SNSF) European Commission PP00P2-190080, TESS Guest Investigator Program Grant 80NSSC21K0364, Spanish Government, European Commission ESP2016-80435-C2-1-R - ESP2016-80435-C2-2-R - PGC2018-098153-B-C33 - PGC2018-098153-B-C31 - ESP2017-87676-C5-1-R - MDM-2017-0737 - PGC2018-098153-BC33, Generalitat de Catalunya/CERCA programme, European Space Agency 4000124370, CRT foundation 2018.2323, National Research, Development & Innovation Office (NRDIO) - Hungary GINOP-2.3.2-15-2016-00003 - K-119517 - K-125015, City of Szombathely 67.177-21/2016, National Aeronautics & Space Administration (NASA), Danmarks Grundforskningsfond DNRF106, European Space Agency PEA 4000119301, Stellar Astrophysics Centre (SAC) at Aarhus University, TASC/TASOC, Gaia Multilateral Agreement, DPAC

Full author list: Lendl, M., Csizmadia, S., Deline, A., Fossati, L., Kitzmann, D., Heng, K., Hoyer, S., Salmon, S., Benz, W., Broeg, C., Ehrenreich, D., Fortier, A., Queloz, D., Bonfanti, A., Brandeker, A., Collier Cameron, A., Delrez, L.a,g,l, Garcia Muñoz, A.m, Hooton, M.J.f, Maxted, P.F.L.i, Morris, B.M., Van Grootel, V., Wilson, T.G., Alibert, Y., Alonso, R., Asquier, J., Bandy, T.f, Bárczy, T.q, Barrado, D.r, Barros, S.C.C.s,t, Baumjohann, W.b, Beck, M., Beck, T., Bekkelien, A., Bergomi, M., Billot, N., Biondi, F., Bonfils, X., Bourrier, V., Busch, M.-D., Cabrera, J., Cessa, V., Charnoz, S., Chazelas, B., Corral Van Damme, C., Davies, M.B., Deleuil, M., Demangeon, O.D.S., Demory, B.-O., Erikson, A., Farinato, J., Fridlund, M., Futyan, D., Gandolfi, D., Gillon, M.l, Guterman, P., Hasiba, J., Hernandez, E., Isaak, K., Kiss, L., Kuntzer, T., Lecavelier Des Etangs, A., Lüftinger, T., Laskar, J., Lovis, C., Magrin, D., Malvasio, L., Marafatto, L., Michaelis, H., Munari, M., Nascimbeni, V., Olofsson, G., Ottacher, H., Ottensamer, R., Pagano, I., Pallé, E., Peter, G., Piazza, D., Piotto, G., Pollacco, D., Ratti, F., Rauer, H., Ragazzoni, R., Rando, N., Ribas, I., Rieder, M., Rohlfs, R., Safa, F., Santos, N.C., Scandariato, G., Ségransan, D., Simon, A.E., Singh, V., Smith, A.M.S., Sordet, M., Sousa, S.G., Steller, M., Szabó, G.M., Thomas, N., Tschentscher, M., Udry, S., Viotto, V., Walter, I., Walton, N.A., Wildi, F., Wolter, D., The CHEOPS space mission dedicated to exoplanet follow-up was launched in December 2019, equipped with the capacity to perform photometric measurements at the 20 ppm level. As CHEOPS carries out its observations in a broad optical passband, it can provide insights into the reflected light from exoplanets and constrain the short-wavelength thermal emission for the hottest of planets by observing occultations and phase curves. Here, we report the first CHEOPS observation of an occultation, namely, that of the hot Jupiter WASP-189 b, a MP ≈ 2MJ planet orbiting an A-type star. We detected the occultation of WASP-189 b at high significance in individual measurements and derived an occultation depth of dF = 87.9 ± 4.3 ppm based on four occultations. We compared these measurements to model predictions and we find that they are consistent with an unreflective atmosphere heated to a temperature of 3435 ± 27 K, when assuming inefficient heat redistribution. Furthermore, we present two transits of WASP-189 b observed by CHEOPS. These transits have an asymmetric shape that we attribute to gravity darkening of the host star caused by its high rotation rate. We used these measurements to refine the planetary parameters, finding a ~25% deeper transit compared to the discovery paper and updating the radius of WASP-189 b to 1.619 ± 0.021RJ. We further measured the projected orbital obliquity to be λ = 86.4-4.4+2.9°, a value that is in good agreement with a previous measurement from spectroscopic observations, and derived a true obliquity of ψ = 85.4 ± 4.3°. Finally, we provide reference values for the photometric precision attained by the CHEOPS satellite: for the V = 6.6 mag star, and using a 1-h binning, we obtain a residual RMS between 10 and 17 ppm on the individual light curves, and 5.7 ppm when combining the four visits., with important contributions to the payload and the ground segment from Austria, Belgium, France, Germany, Hungary, Italy, Portugal, Spain, Sweden, and the United Kingdom. The Swiss participation to CHEOPS has been supported by the Swiss Space Office (SSO) in the framework of the Prodex Programme and the Activités Nationales Complémentaires (ANC), the Universities of Bern and Geneva as well as well as of the NCCR PlanetS and the Swiss National Science Foundation. M.L.E. acknowledges support from the Austrian Research Promotion Agency (FFG) under project 859724 “GRAPPA”. Sz. Cs. thanks DFG Research Unit 2440: ‘Matter Under Planetary Interior Conditions: High Pressure, Planetary, and Plasma Physics’ for support. Sz. Cs. acknowledges support by DFG grants RA 714/14-1 within the DFG Schwerpunkt SPP 1992: “Exploring the Diversity of Extrasolar Planets”. A.D.E. and D.E.H. acknowledge support from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (project FOUR ACES; grant agreement no. 724427). M.J.H. acknowledges the support of the Swiss National Fund under grant 200020_172746. The Spanish scientific participation in CHEOPS has been supported by the Spanish Ministry of Science and Innovation and the European Regional Development Fund through grants ESP2016-80435-C2-1-R, ESP2016-80435-C2-2-R, ESP2017-87676-C5-1-R, PGC2018-098153-B-C31, PGC2018-098153-B-C33, and MDM-2017-0737 Unidad de Excelencia María de Maeztu–Centro de Astrobiología (INTA-CSIC), as well as by the Generalitat de Catalunya/CERCA programme. The MOC activities have been supported by the ESA contract No. 4000124370. This work was supported by FCT – Fundação para a Ciência e a Tecnologia through national funds and by FEDER through COMPETE2020 – Programa Operacional Competitividade e Internacionalização by these grants: UID/FIS/04434/2019; UIDB/04434/2020; UIDP/04434/2020; PTDC/FIS-AST/32113/2017 & POCI-01-0145-FEDER-032113; PTDC/FIS-AST/28953/2017 & POCI-01-0145-FEDER-028953; PTDC/FIS-AST/28987/2017 & POCI-01-0145-FEDER-028987. S.C.C.B. and S.G.S. acknowledge support from FCT through FCT contracts nr. IF/01312/2014/CP1215/CT0004, IF/00028/2014/CP1215/CT0002. O.D.S.D. is supported in the form of work contract (DL 57/2016/CP1364/CT0004) funded by national funds through Fundação para a Ciência e Tecnologia (FCT). The Belgian participation to CHEOPS has been supported by the Belgian Federal Science Policy Office (BELSPO) in the framework of the PRODEX Program, and by the University of Liege through an ARC grant for Concerted Research Actions financed by the Wallonia-Brussels Federation. M.G. is F.R.S.-FNRS Senior Research Associate. S.S. has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 833925, project STAREX). Gy.S. acknowledges funding from the Hungarian National Research, Development and Innovation Office (NKFIH) grant GINOP-2.3.2-15-2016-00003 and K-119517. For Italy, CHEOPS activities have been supported by the Italian Space Agency, under the programs: ASI-INAF n. 2013-016-R.0 and ASI-INAF n. 2019-29-HH.0. The team at LAM acknowledges CNES funding for the development of the CHEOPS DRP, including grants 124378 for O.D. and 837319 for S.H. X.B., S.C., D.G., M.F. and J.L. acknowledge their role as an ESA-appointed CHEOPS science team members.

Context. Gaia Early Data Release 3 (Gaia EDR3) provides accurate astrometry for about 1.6 million compact (QSO-like) extragalactic sources, 1.2 million of which have the best-quality five-parameter astrometric solutions., Aims. The proper motions of QSO-like sources are used to reveal a systematic pattern due to the acceleration of the solar systembarycentre with respect to the rest frame of the Universe. Apart from being an important scientific result by itself, the acceleration measured in this way is a good quality indicator of the Gaia astrometric solution., Methods. Theeffect of the acceleration was obtained as a part of the general expansion of the vector field of proper motions in vector spherical harmonics (VSH). Various versions of the VSH fit and various subsets of the sources were tried and compared to get the most consistent result and a realistic estimate of its uncertainty. Additional tests with the Gaia astrometric solution were used to get a better idea of the possible systematic errors in the estimate., Results. Our best estimate of the acceleration based on Gaia EDR3 is (2.32 +/- 0.16) x 10(-10) m s(-2) (or 7.33 +/- 0.51 km s(-1) Myr-1) towards alpha = 269.1 degrees +/- 5.4 degrees, delta = -31.6 degrees +/- 4.1 degrees, corresponding to a proper motion amplitude of 5.05 +/- 0.35 mu as yr(-1). This is in good agreement with the acceleration expected from current models of the Galactic gravitational potential. We expect that future Gaia data releases will provide estimates of the acceleration with uncertainties substantially below 0.1 mu as yr(-1).

Szabó, Gy. M., et al., AU Mic is a young planetary system with a resolved debris disc showing signs of planet formation and two transiting warm Neptunes near mean-motion resonances. Here we analyse three transits of AU Mic b observed with the CHaracterising ExOPlanet Satellite (CHEOPS), supplemented with sector 1 and 27 Transiting Exoplanet Survey Satellite (TESS) photometry, and the All-Sky Automated Survey from the ground. The refined orbital period of AU Mic b is 8.462995 ± 0.000003 d, whereas the stellar rotational period is Prot = 4.8367 ± 0.0006 d. The two periods indicate a 7:4 spin-orbit commensurability at a precision of 0.1%. Therefore, all transits are observed in front of one of the four possible stellar central longitudes. This is strongly supported by the observation that the same complex star-spot pattern is seen in the second and third CHEOPS visits that were separated by four orbits (and seven stellar rotations). Using a bootstrap analysis we find that flares and star spots reduce the accuracy of transit parameters by up to 10% in the planet-to-star radius ratio and the accuracy on transit time by 3-4 min. Nevertheless, occulted stellar spot features independently confirm the presence of transit timing variations (TTVs) with an amplitude of at least 4 min. We find that the outer companion, AU Mic c, may cause the observed TTVs.

Binge drinking is short-term drinking that achieves blood alcohol levels of 0.08 g/dl or above. It exhibits well-established sex differences in GABAergic inhibitory neurotransmission, including extrasynaptic δ subunit-containing GABAA receptors (δ-GABAARs) that mediate tonic inhibition, or synaptic γ2-containing GABAARs which underlie fast, synaptic, phasic inhibition have been implicated in sex differences in binge drinking. Ovarian hormones regulate δ-GABAARs, further implicating these receptors in potential sex differences. Here, we explored the contribution of extrasynaptic δ-GABAARs to male and female binge-like drinking in a critical area of mesolimbic circuitry—the ventral tegmental area (VTA). Quantitative PCR revealed higher Gabrd transcript levels and larger tonic currents in the VTA of females compared to males. In contrast, male and female Gabrg2 transcript levels and measures of phasic inhibition were equivalent. Intra-VTA infusion of AAV-Cre-GFP in floxed Gabrd mice downregulated δ-GABAARs and decreased binge-like drinking in females. There was no significant difference in either male or female mice after GABAAR γ2 subunit reduction in the VTA following AAV-Cre-GFP infusion in floxed Gabrg2 mice. Collectively, these findings suggest sex differences and GABAAR subunit specificity in alcohol intake.

0, info:eu-repo/semantics/published

Aims. We describe the photometric content of the second data release of the Gaia project (Gaia DR2) and its validation along with the quality of the data. Methods. The validation was mainly carried out using an internal analysis of the photometry. External comparisons were also made, but were limited by the precision and systematics that may be present in the external catalogues used. Results. In addition to the photometric quality assessment, we present the best estimates of the three photometric passbands. Various colour-colour transformations are also derived to enable the users to convert between the Gaia and commonly used passbands. Conclusions. The internal analysis of the data shows that the photometric calibrations can reach a precision as low as 2 mmag on individual CCD measurements. Other tests show that systematic effects are present in the data at the 10 mmag level., Comment: This version has corrections to Appendix A. All the SDSS transformations have been corrected. Tables A.1 and A.2 have changed for the SDSS relationships. Three of the subfigures in Figure A.1 have changed. The author list has been expanded

Deciphering the assembly history of the Milky Way is a formidable task, which becomes possible only if one can produce high-resolution chrono-chemo-kinematical maps of the Galaxy. Data from large-scale astrometric and spectroscopic surveys will soon provide us with a well-defined view of the current chemo-kinematical structure of the Milky Way, but will only enable a blurred view on the temporal sequence that led to the present-day Galaxy. As demonstrated by the (ongoing) exploitation of data from the pioneering photometric missions CoRoT, Kepler, and K2, asteroseismology provides the way forward: solar-like oscillating giants are excellent evolutionary clocks thanks to the availability of seismic constraints on their mass and to the tight age-initial-mass relation they adhere to. In this paper we identify five key outstanding questions relating to the formation and evolution of the Milky Way that will need precise and accurate ages for large samples of stars to be addressed, and we identify the requirements in terms of number of targets and the precision on the stellar properties that are needed to tackle such questions. By quantifying the asteroseismic yields expected from PLATO for red-giant stars, we demonstrate that these requirements are within the capabilities of the current instrument design, provided that observations are sufficiently long to identify the evolutionary state and allow robust and precise determination of acoustic-mode frequencies. This will allow us to harvest data of sufficient quality to reach a 10% precision in age. This is a fundamental pre-requisite to then reach the more ambitious goal of a similar level of accuracy, which will only be possible if we have to hand a careful appraisal of systematic uncertainties on age deriving from our limited understanding of stellar physics, a goal which conveniently falls within the main aims of PLATO's core science., 17 pages, 9 figures, accepted for publication in Astronomical Notes

The Gaia Photometric Science Alerts (GSA) group is the Gaia Data Processing and Analysis Consortium (DPAC) unit responsible for releasing alerts on Gaia transient candidates from a daily flow of initially reduced data. In preparation for obtaining the rates for different transient families with Gaia , one of the main goals of GSA is to reliably identify and characterize the candidates. In this article, we describe the simulations used to understand and predict possible selection effects and the techniques used to identify the nature of the transient alerts provided by Gaia.

The Gaia Science Alerts project (GSA) aims to augment a precision survey of the Milky Way with a controlled, precision survey of all classes of transient phenomena. While onboard BP/RP spectra from Gaia will ultimately allow us to classify many Gaia Alerts based on Gaia data alone, in the initial phases of the GSA project it is necessary to verify and classify discoveries with ground-based spectroscopic followup. In this article, we describe a subset of the ongoing Gaia Alerts followup programmes, and some of the initial science results from this work.

This paper gives a brief overview of the Gaia Research for European Astronomy Training (GREAT) network activity plan for the period 2015–2020, aiming to support the maximisation of scientific exploitation of the data from Gaia.

The Gaia-ESO Survey is obtaining high-quality spectroscopic data for about 10^5 stars using FLAMES at the VLT. UVES high-resolution spectra are being collected for about 5000 FGK-type stars. These UVES spectra are analyzed in parallel by several state-of-the-art methodologies. Our aim is to present how these analyses were implemented, to discuss their results, and to describe how a final recommended parameter scale is defined. We also discuss the precision (method-to-method dispersion) and accuracy (biases with respect to the reference values) of the final parameters. These results are part of the Gaia-ESO 2nd internal release and will be part of its 1st public release of advanced data products. The final parameter scale is tied to the one defined by the Gaia benchmark stars, a set of stars with fundamental atmospheric parameters. A set of open and globular clusters is used to evaluate the physical soundness of the results. Each methodology is judged against the benchmark stars to define weights in three different regions of the parameter space. The final recommended results are the weighted-medians of those from the individual methods. The recommended results successfully reproduce the benchmark stars atmospheric parameters and the expected Teff-log g relation of the calibrating clusters. Atmospheric parameters and abundances have been determined for 1301 FGK-type stars observed with UVES. The median of the method-to-method dispersion of the atmospheric parameters is 55 K for Teff, 0.13 dex for log g, and 0.07 dex for [Fe/H]. Systematic biases are estimated to be between 50-100 K for Teff, 0.10-0.25 dex for log g, and 0.05-0.10 dex for [Fe/H]. Abundances for 24 elements were derived: C, N, O, Na, Mg, Al, Si, Ca, Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Y, Zr, Mo, Ba, Nd, and Eu. The typical method-to-method dispersion of the abundances varies between 0.10 and 0.20 dex., Comment: 39 pages, A&A accepted

Purpose: Radiological measurement scores are used by orthopaedic physiotherapists in triage and surveillance of patients with degenerative changes of the tibiofemoral and patellofemoral joints. The purpose of this study was to estimate the intra- and inter-observer reliability of a radiological measurement score to assess patellofemoral joint osteoarthritis, the Jones Patellofemoral Osteoarthritis Score (JPOS), with an orthopaedic physiotherapist and three grades of junior surgeons/doctors. Methods: A total of 390 skyline X-rays of the patellofemoral joint were reviewed on 2 occasions, 4 weeks apart, by an orthopaedic physiotherapist, 2 orthopaedic surgeons, and an orthopaedic doctor. Intra- and inter-observer reliability of the JPOS was calculated using a weighted kappa analysis. Results: The results indicated that while there was good overall intra-observer agreement for this measurement score for all assessors, inter-observer reliability was generally poor between the orthopaedic physiotherapist and the orthopaedic surgeons/doctor. Conclusion: Our findings call into question the use of the JPOS by orthopaedic physiotherapists working in triage or orthopaedic surveillance programmes with other orthopaedic clinicians.

The Oxford unicompartmental knee replacement gives good results in patients with symptomatic osteoarthritis of the medial compartment. Previous studies have suggested that the presence of radiolucent lines (RLLs) does not reflect a poor outcome in such patients. However, the reliability and validity of this assessment have not been determined. Our aim was to assess the intra- and interobserver reliability and the sensitivity and specificity of the assessment of RLLs around both tibial and femoral components using standard radiographs. Two reviewers assessed the radiographs of 45 patients who had loosening of the tibial or femoral component confirmed at revision surgery and compared them with those of a series of 45 asymptomatic patients matched for age and gender. The results suggested that, using standard radiographs, tibial RLLs were 63.6% sensitive and 94.4% specific and femoral RLLs 63.9% sensitive and 72.7% specific for loosening. Overall intra- and interobserver reliability was highly variable, but zonal analysis showed that lucency at the tip of the femoral peg was significantly associated with loosening of the femoral component. Fluoroscopically guided radiographs may improve the zonal reliability of the assessment of RLLs, but further independent and comparative studies are required. In the meantime, the innocence of the physiological RLLs detected by standard radiographs should be viewed with caution.

In the version of this Article originally published, the authors Pablo Huijse and Pablo Huentelemu were mistakenly affiliated with the University of California, Berkeley, and their affiliation to the University of Chile was omitted. Pablo Huijse’s affiliation to the Universidad Austral de Chile was also omitted.

We report the follow-up at 12 years of the use of the Elite Plus total hip replacement (THR). We have previously reported the results at a mean of 6.4 years. Of the 217 patients (234 THRs), 83 had died and nine had been lost to follow-up. The patients were reviewed radiologically and clinically using the Oxford hip score. Of the 234 THRs, 19 (8.1%) had required a revision by the final follow-up in all but one for aseptic loosening. Survivorship analysis for revision showed a survival of 93.9% (95% confidence interval (CI) 89.2 to 96.5) at ten years, and of 88.0% (95% CI 81.8 to 92.3) at 12 years. At the final follow-up survival analysis showed that 37% (95% CI 37.3 to 44.7) of the prostheses had either failed radiologically or had been revised. Patients with a radiologically loose femoral component had a significantly poorer Oxford hip score than those with a well-fixed component (p = 0.03). Radiological loosening at 6.4 years was predictive of failure at 12 years. Medium-term radiographs and clinical scores should be included in the surveillance of THR to give an early indication of the performance of specific implants.

We present a study of the detectability of transient events associated with galaxies for the Gaia European Space Agency astrometric mission. We simulated the on-board detections, and on-ground processing for a mock galaxy catalogue to establish the properties required for the discovery of transient events by Gaia, specifically tidal disruption events (TDEs) and supernovae (SNe). Transients may either be discovered by the on-board detection of a new source or by the brightening of a previously known source. We show that Gaia transients can be identified as new detections on-board for offsets from the host galaxy nucleus of 0.1--0.5,arcsec, depending on magnitude and scanning angle. The Gaia detection system shows no significant loss of SNe at close radial distances to the nucleus. We used the detection efficiencies to predict the number of transients events discovered by Gaia. For a limiting magnitude of 19, we expect around 1300 SNe per year: 65% SN Ia, 28% SN II and 7% SN Ibc, and ~20 TDEs per year., Comment: 17 pages, 10 figures, accepted by MNRAS

We reviewed 150 patients (183 knees) who underwent mini-incision unicompartmental knee arthroplasty (Oxford). Mean age was 71.5 (36–92) years. Review was conducted at least 12 months following surgery. To assess results, we used the Oxford knee questionnaire, modified Grimby score, return to sport and work, knee “normality” and patient general health. The mean Oxford knee score was 22.17 (range 12–54). Kneeling scored worse than other activities. No significant age or gender difference was found. Mean modified Grimby score was 3.89, equating to moderate exercise less than 2 h a week. Patients with “artificial-feeling” knees had significantly worse scores than patients with normal/near-normal-feeling knees. Patients who returned to/increased sporting activity had better Oxford scores than those who did not. Ninety-four percent of patients working pre-operatively returned to work. Sixty-seven percent continued at the same level of or increased sporting activity. Oxford knee scores and return to sport compared well to published data. Results regarding modified Grimby score, return to work and pain relief were encouraging. The best results were achieved in active patients who felt their health was good and their knee felt normal or near normal following surgery.

There has been debate about the role of unicompartmental knee replacement in the presence of radiologically identifiable degenerative changes of the patellofemoral joint. We studied 195 knees in 163 patients in whom an Oxford unicompartmental knee replacement had been performed for medial osteoarthritis between January 2004 and July 2007. The mean age of the patients was 66 years (51 to 93). The degree of degenerative change of the patellofemoral joint was assessed using Jones’ criteria. Functional outcome was assessed at a mean of 3.4 years (2 to 7) post-operatively, using the Oxford knee score and the Short-form 12 score. Degenerative changes of the patellofemoral joint were seen pre-operatively in 125 knees (64%) on the skyline radiographs. There was no statistically significant difference in the Oxford knee or Short-form 12 scores between those patients who had patellofemoral osteoarthritis pre-operatively and those who did not (p = 0.22 and 0.54, respectively). These results support the opinion expressed at the designer’s hospital that degenerative changes of the patellofemoral joint in isolation should not be considered to be a contraindication to medial Oxford unicompartmental knee replacement.

The INT/WFC Photometric H-Alpha Survey of the Northern Galactic Plane (IPHAS) is a 1800 square degrees imaging survey covering Galactic latitudes |b| < 5 deg and longitudes l = 30 to 215 deg in the r, i and H-alpha filters using the Wide Field Camera (WFC) on the 2.5-metre Isaac Newton Telescope (INT) in La Palma. We present the first quality-controlled and globally-calibrated source catalogue derived from the survey, providing single-epoch photometry for 219 million unique sources across 92% of the footprint. The observations were carried out between 2003 and 2012 at a median seeing of 1.1 arcsec (sampled at 0.33 arcsec/pixel) and to a mean 5\sigma-depth of 21.2 (r), 20.0 (i) and 20.3 (H-alpha) in the Vega magnitude system. We explain the data reduction and quality control procedures, describe and test the global re-calibration, and detail the construction of the new catalogue. We show that the new calibration is accurate to 0.03 mag (rms) and recommend a series of quality criteria to select the most reliable data from the catalogue. Finally, we demonstrate the ability of the catalogue's unique (r-Halpha, r-i) diagram to (1) characterise stellar populations and extinction regimes towards different Galactic sightlines and (2) select H-alpha emission-line objects. IPHAS is the first survey to offer comprehensive CCD photometry of point sources across the Galactic Plane at visible wavelengths, providing the much-needed counterpart to recent infrared surveys., Comment: Accepted for publication in MNRAS. The catalogue is available in full from the survey website at http://www.iphas.org and has been submitted to Vizier

Displaced distal radial fractures with extensive dorsal comminution and plastic cancellous deformation are unstable and frequently cause treatment problems since there is no single, reliable method of treatment, notably in osteoporotic bone. We present a method of holding unstable distal radial fractures with blunt ended K-wires via intrafocal and intramedullary insertion, so modifying the Kapandji technique. Wires were placed dorsally, radially and when necessary from the volar direction depending on fracture configuration. Over a 7-year period (1992-1999) we treated 102 patients with unstable distal radial fractures in this way. Of these, 80 were followed up for 6-42 weeks according to clinical need and scored radiologically and functionally using modified Lidstrom scoring system. Results showed that 92 and 95% of these patients achieved good or excellent results in these scoring systems, respectively. We present this as a useful and reliable method of treating these common fractures, particularly in osteoporotic bone.

Werner’s syndrome is a rare condition usually presenting as premature ageing in adults. Over a period of 30 years we have followed two siblings with extensive musculoskeletal manifestations including a soft-tissue tumour, insufficiency fractures, nonunion and tendonitis, with associated problems of management. The literature is reviewed.

Background and Methods Although generalized convulsive status epilepticus is a life-threatening emergency, the best initial drug treatment is uncertain. We conducted a five-year randomized, double-blind, multicenter trial of four intravenous regimens: diazepam (0.15 mg per kilogram of body weight) followed by phenytoin (18 mg per kilogram), lorazepam (0.1 mg per kilogram), phenobarbital (15 mg per kilogram), and phenytoin (18 mg per kilogram). Patients were classified as having either overt generalized status epilepticus (defined as easily visible generalized convulsions) or subtle status epilepticus (indicated by coma and ictal discharges on the electroencephalogram, with or without subtle convulsive movements such as rhythmic muscle twitches or tonic eye deviation). Treatment was considered successful when all motor and electroencephalographic seizure activity ceased within 20 minutes after the beginning of the drug infusion and there was no return of seizure activity during the next 40 minutes. Analyse...

Changes in residual ATP concentrations were investigated following subcellular fractionation of rat brain cortex after a prolonged period of status epilepticus induced by sequential administration of lithium and pilocarpine. After 2 h of continuous high-amplitude rapid spiking on EEG, we found significantly decreased levels of residual ATP in the homogenate and mitochondria fractions from status epilepticus rat brains compared to matched controls. No difference in residual ATP level was observed in the synaptosomal preparations of status epilepticus animals compared to controls. Inorganic phosphate concentration in the status animals was higher than controls in the cytosolic fraction only. F1-ATPase activity, an enzymatic indicator of mitochondrial ATP synthesis rate, was significantly higher in the status brains, whereas other mitochondrial enzymes were not different in the status and control rat groups. These findings, together with our earlier report of reduced synaptosomal ecto-ATPase activity, suggest that either the corresponding in vivo ATP concentrations were reduced as a result of status epilepticus or other biochemical changes had occurred that facilitated the hydrolysis of ATP following decapitation. Controls for and measurement of such other changes failed to provide an explanation for the observed changes in residual ATP.

We present a case of an ipsilateral tibial shaft fracture and a distal tibial triplane fracture with an intact fibula in a 14-year-old boy. Computed tomography revealed the distal tibial triplane fracture with a 2.6-mm displaced Tillaux fragment and a posterior malleolar shear fragment. Open reduction and internal fixation was performed to optimise healing and outcome. This is a rare injury, for which a high index of suspicion is needed for diagnosis. Missing the intra-articular distal tibial triplane fracture could result in a disabling angular deformity (mostly varus) or limb-length discrepancy secondary to premature partial closure of the distal physis.

Unicompartmental knee replacement (UKR) is an option for the treatment of isolated medial compartment osteoarthritis. A commonly perceived potential advantage is that revision of a UKR is straightforward. The purpose of this study was to determine the early outcomes and the level of complexity of revisions of Oxford UKRs performed at our hospital. A retrospective review of a prospective database of all phase III Oxford UKRs was undertaken. This identified 89 Oxford UKRs which were revised at our institution between 2002 and 2008. The median time from the primary procedure to revision was 19 months (interquartile range 2–73 months). Nine were revised to another UKR. Eighty were revised to a total knee replacement (TKR). Fifty-three were revised with primary TKR components. Twenty-seven were revised using stems and/or augments. The median overall tibial component thickness (including augments) was 15 mm. Forty-five knees had an overall tibial component thickness greater than 15 mm. A primary Oxford UKR bearing thickness of greater than 6 mm was associated with an increased likelihood of requiring revision components. On the basis of this review, tibial bone defects were commonly encountered when revising UKRs. Reconstruction with either an augment and a stem, or thick polyethylene component was often required. We recommend that the potential complexity of revision for UKR failure should be borne in mind when considering a primary Oxford UKR.

Wide-field multi-object spectroscopy is a high priority for European astronomy over the next decade. Most 8-10m telescopes have a small field of view, making 4-m class telescopes a particularly attractive option for wide-field instruments. We present a science case and design drivers for a wide-field multi-object spectrograph (MOS) with integral field units for the 4.2-m William Herschel Telescope (WHT) on La Palma. The instrument intends to take advantage of a future prime-focus corrector and atmospheric-dispersion corrector that will deliver a field of view 2 deg in diameter, with good throughput from 370 to 1,000 nm. The science programs cluster into three groups needing three different resolving powers R: (1) high-precision radial-velocities for Gaia-related Milky Way dynamics, cosmological redshift surveys, and galaxy evolution studies (R = 5,000), (2) galaxy disk velocity dispersions (R = 10,000) and (3) high-precision stellar element abundances for Milky Way archaeology (R = 20,000). The multiplex requirements of the different science cases range from a few hundred to a few thousand, and a range of fibre-positioner technologies are considered. Several options for the spectrograph are discussed, building in part on published design studies for E-ELT spectrographs. Indeed, a WHT MOS will not only efficiently deliver data for exploitation of important imaging surveys planned for the coming decade, but will also serve as a test-bed to optimize the design of MOS instruments for the future E-ELT., Comment: 15 pages, 4 figures, submitted to SPIE Astronomical Telescopes and Instrumentation 2010

We retrospectively studied the major complications occurring after one- and two-stage bilateral unicompartmental knee replacements (UKR). Between 1999 and 2008, 911 patients underwent 1150 UKRs through a minimally invasive approach in our unit. Of these, 159 patients (318 UKRs) had one-stage and 80 patients (160 UKRs) had two-stage bilateral UKRs. The bilateral UKR groups were comparable in age and American Society of Anaesthesiology grade, but more women were in the two-stage group (p = 0.019). Mechanical thromboprophylaxis was used in all cases. Major complications were recorded as death, pulmonary embolus, proximal deep-vein thrombosis and adverse cardiac events within 30 days of surgery. No statistical differences between the groups were found regarding the operating surgeon, the tourniquet time or minor complications except for distal deep-vein thrombosis. The anaesthetic times were longer for the two-stage group (p = 0.0001). Major complications were seen in 13 patients (8.2%) with one-stage operations but none were encountered in the two-stage group (p = 0.005). Distal deep-vein thrombosis was more frequent in the two-stage group (p = 0.036). Because of the significantly higher risk of major complications associated with one-stage bilateral UKR we advocate caution before undertaking such a procedure.

Nova V458 Vul erupted on 2007 August 8th and reached a visual magnitude of 8.1 a few days later. H$\alpha$ images obtained six weeks before the outburst as part of the IPHAS galactic plane survey reveal an 18th magnitude progenitor surrounded by an extended nebula. Subsequent images and spectroscopy of the nebula reveal an inner nebular knot increasing rapidly in brightness due to flash ionization by the nova event. We derive a distance of 13 kpc based on light travel time considerations, which is supported by two other distance estimation methods. The nebula has an ionized mass of 0.2 M$_{\odot}$ and a low expansion velocity: this rules it out as ejecta from a previous nova eruption, and is consistent with it being a ~14,000 year old planetary nebula, probably the product of a prior common envelope (CE) phase of evolution of the binary system. The large derived distance means that the mass of the erupting WD component of the binary is high. We identify two possible evolutionary scenarios, in at least one of which the system is massive enough to produce a Type Ia supernova on merging., Comment: 5 pages, 2 figures. Accepted for publication in ApJL

The INT/WFC Photometric H-alpha Survey of the Northern Galactic Plane (IPHAS) is an imaging survey being carried out in H-alpha, r' and i' filters, with the Wide Field Camera (WFC) on the 2.5-metre Isaac Newton Telescope (INT) to a depth of r'=20 (10 sigma). The survey is aimed at revealing large scale structure in our local galaxy, and also the properties of key early and late populations making up the Milky Way. Mapping emission line objects enables a particular focus on objects in the young and old stages of stellar evolution ranging from early T-Tauri stars to late planetary nebulae. In this paper we present the IPHAS Initial Data Release, primarily a photometric catalogue of about 200 million unique objects, coupled with associated image data covering about 1600 square degrees in three passbands. We note how access to the primary data products has been implemented through use of standard virtual observatory publishing interfaces. Simple traditional web access is provided to the main IPHAS photometric catalogue, in addition to a number of common catalogues (such as 2MASS) which are of immediate relevance. Access through the AstroGrid VO Desktop opens up the full range of analysis options, and allows full integration with the wider range of data and services available through the Virtual Observatory. The IDR represents the largest dataset published primarily through VO interfaces to date, and so stands as an examplar of the future of survey data mining. Examples of data access are given, including a cross-matching of IPHAS photometry with sources in the UKIDSS Galactic Plane Survey that validates the existing calibration of the best data., Comment: 17 pages, 23 figures, MNRAS in press. Version with full-resolution figures can be found at http://casu.ast.cam.ac.uk/surveys-projects/iphas

This study describes the chemometric treatment of vanillin fingerprint chromatograms to distinguish vanillin from different sources. Prior to principal component analysis, which is used to discriminate vanillin from different origins, the fingerprints are aligned. Three alignment algorithms are tested, correlation optimized warping (COW), target peak alignment (TPA) and semi-parametric time warping (STW). The performance of the three algorithms is evaluated and the effect of the different alignments on the PCA score plots is investigated. The alignment obtained with STW differs somewhat from that with COW and TPA. However, equivalent score plots were obtained regarding the different vanillin groups.

We prospectively studied 217 patients who underwent 234 Elite Plus total hip arthroplasties. At a mean of 6.4 (SD 0.7) years post-operatively, 39 patients had died and 22 were either lost to follow-up or had no radiographs available. Clinical (Oxford hip score) and radiological assessments were performed on 156 patients (168 hip arthroplasties) who had a mean age of 67.7 (SD 9.7) years at operation. In the assessed group, 26 of 159 (16.4%) of femoral stems which had not already been revised and 19 of 159 (11.9%) of acetabular cups were definitely loose. In total, 52 of 168 (31%) of hips had either been revised or had definite evidence of loosening of a component. We could not establish any relationship between clinical and radiological outcomes. Despite the fact that the clinical outcome and rate of revision for the Elite Plus appeared to meet international standards, our findings give us cause for concern. We believe that joint registries should include radiological surveillance in order to provide reliable information about medium-term outcomes for hip prostheses.

Arthrofibrosis following total knee replacement (TKR) is a relatively common complication which results in a reduction in knee range of movement and patient dissatisfaction. A retrospective study examined the relationship between anticoagulation with therapeutic warfarin and rates of arthrofibrosis following TKR. Arthrofibrosis was defined as less than 80 degrees of knee flexion 6-8 weeks post-TKR. Patients were warfarinised if they had a history of thrombophilic tendencies or medical conditions necessitating anti-coagulation, rather than as routine thromboprophylaxis. All other patients received thromboprophylaxis using low molecular weight heparin. A total of 728 patients underwent 874 primary TKR between 1993 and 2002 in one centre, performed by four surgeons. Mean age was 68 years (range 48-89 years) and there were 483 female and 391 male knees. Eighty cases were warfarinised post-operatively (53 female, 27 male). Overall, 83 of 874 TKRs (9%) had arthrofibrosis (57 female, 26 male) requiring manipulation under anaesthetic (MUA). In the warfarinised group, 21 knees (26%) had an MUA (15 female, 6 male). This compared to 62 cases (8%) requiring MUA in the non-warfarinised group (42 female, 20 male). There was a statistically significant difference on Fisher's exact testing (P

An otherwise fit and well 40-year-old left-handed male computer operator presented with a minimally symptomatic lump of 2 years duration in his non-dominant anatomical snuffbox. There was no history of trauma. This was pulsatile and did not transilluminate despite being referred as a ganglion. MRI scan confirmed the presence of a 1.5 cm radial artery aneurysm fed by the radial artery and draining to the second digital artery. In view of his lack of symptoms the patient declined surgical intervention. Literature review reveals radial artery aneurysms to be very rare and usually traumatic in origin. Iatrogenic pseudoaneurysms are widely reported following cannulation. We are unaware of previous descriptions of an idiopathic, isolated radial artery aneurysm.

We compare the intra- and interobserver reproducibility of classifications of tibial plateau fractures most commonly used in our clinical practice. These were the AO and Schatzker classifications.Agreement was measured using kappa coefficients on the data obtained from three observers reviewing 30 fractures and these values were interpreted according to Landis and Koch.It was found that both classifications were substantially reliable with regards to intraobserver reliability but that the Schatzker system was only fairly reliable and the AO classification moderately reliable with regards to interobserver reliability. Breaking down the AO classification, with regards to intraobserver reliability, the AO group was substantially reliable and the type excellently reliable. For interobserver reliability, the AO group was moderately reliable while the AO type was substantially reliable.For tibial plateau fractures seen on plain x-ray, the AO classification is more reliable between observers than the Schatzker classification.

Werner's syndrome is a rare condition usually presenting as premature ageing in adults. Over a period of 30 years we have followed two siblings with extensive musculoskeletal manifestations including a soft-tissue tumour, insufficiency fractures, nonunion and tendonitis, with associated problems of management. The literature is reviewed.

Changes in residual ATP concentrations were investigated following subcellular fractionation of rat brain cortex after a prolonged period of status epilepticus induced by sequential administration of lithium and pilocarpine. After 2 h of continuous high-amplitude rapid spiking on EEG, we found significantly decreased levels of residual ATP in the homogenate and mitochondria fractions from status epilepticus rat brains compared to matched controls. No difference in residual ATP level was observed in the synaptosomal preparations of status epilepticus animals compared to controls. Inorganic phosphate concentration in the status animals was higher than controls in the cytosolic fraction only. F1-ATPase activity, an enzymatic indicator of mitochondrial ATP synthesis rate, was significantly higher in the status brains, whereas other mitochondrial enzymes were not different in the status and control rat groups. These findings, together with our earlier report of reduced synaptosomal ecto-ATPase activity, suggest that either the corresponding in vivo ATP concentrations were reduced as a result of status epilepticus or other biochemical changes had occurred that facilitated the hydrolysis of ATP following decapitation. Controls for and measurement of such other changes failed to provide an explanation for the observed changes in residual ATP.

Classes and functions of secondary products from plants, J.B. Harborne characterization and control of secondary metabolism, A.J. Paar et al agricultural production and extraction, S.G. Deans and K.P. Svoboda modern methods of secondary product separation and analysis, T.A. van Beek structure elucidation of plant secondary products, G. Massiot et al plant drug discovery and development, M. Simmonds et al conservation of plant resources, M. Simmonds and M. Maunder disease prevention and plant dietary substances, G.R. Williamson et al manipulation of plant chemical production by genetic engineering, C.R. Martin and A.J. Michael production of biologically-active proteins in plants, G. Lomonossoff biotransformations, M.C.R. Franssen et al biotechnology and plant secondary products - the future, V. De Luca.

Purpose This study was designed to measure the brain penetration of phenytoin (PHT) after intravenous (i.v.) administration of either standard PHT or fosphenytoin (FPHT), a PHT prodrug. The study was formulated to answer the question whether the time required for FPHT to be converted to PHT in the bloodstream would delay the accumulation of PHT in brain. Methods Four rats were sampled at various times after intravenous infusion of 30 mg/kg PHT i.v. or 30 mg/kg PHT equivalents of FPHT i.v. PHT was measured in serum, protein-free ultrafiltrate, and in brain, by using high-performance liquid chromatography. Results Although the initial PHT-free fraction was significantly higher for FPHT-treated rats than it was for PHT-treated rats, brain PHT levels were significantly reduced after infusion of FPHT. Conclusions When FPHT is used for treatment of generalized status epilepticus, it should be anticipated that lower initial brain PHT levels will be achieved than are typically found with standard PHT.

Although generalized convulsive status epilepticus is a life-threatening emergency, the best initial drug treatment is uncertain. We conducted a five-year randomized, double-blind, multicenter trial of four intravenous regimens: diazepam (0.15 mg per kilogram of body weight) followed by phenytoin (18 mg per kilogram), lorazepam (0.1 mg per kilogram), phenobarbital (15 mg per kilogram), and phenytoin (18 mg per kilogram). Patients were classified as having either overt generalized status epilepticus (defined as easily visible generalized convulsions) or subtle status epilepticus (indicated by coma and ictal discharges on the electroencephalogram, with or without subtle convulsive movements such as rhythmic muscle twitches or tonic eye deviation). Treatment was considered successful when all motor and electroencephalographic seizure activity ceased within 20 minutes after the beginning of the drug infusion and there was no return of seizure activity during the next 40 minutes. Analyses were performed with data on only the 518 patients with verified generalized convulsive status epilepticus as well as with data on all 570 patients who were enrolled.Three hundred eighty-four patients had a verified diagnosis of overt generalized convulsive status epilepticus. In this group, lorazepam was successful in 64.9 percent of those assigned to receive it, phenobarbital in 58.2 percent, diazepam plus phenytoin in 55.8 percent, and phenytoin in 43.6 percent (P=0.02 for the overall comparison among the four groups). Lorazepam was significantly superior to phenytoin in a pairwise comparison (P=0.002). Among the 134 patients with a verified diagnosis of subtle generalized convulsive status epilepticus, no significant differences among the treatments were detected (range of success rates, 7.7 to 24.2 percent). In an intention-to-treat analysis, the differences among treatment groups were not significant, either among the patients with overt status epilepticus (P=0.12) or among those with subtle status epilepticus (P=0.91). There were no differences among the treatments with respect to recurrence during the 12-hour study period, the incidence of adverse reactions, or the outcome at 30 days.As initial intravenous treatment for overt generalized convulsive status epilepticus, lorazepam is more effective than phenytoin. Although lorazepam is no more efficacious than phenobarbital or diazepam plus phenytoin, it is easier to use.