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The strong interaction is not well understood at low energy, or for interactions with low momentum transfer $Q^2$, but one of the clearest insights we have comes from Chiral Perturbation Theory ($\chi$PT). This effective treatment gives testable predictions for the nucleonic generalized polarizabilities -- fundamental quantities describing the nucleon's response to an external field. We have measured the proton's generalized spin polarizabilities in the region where $\chi$PT is expected to be valid. Our results include the first ever data for the transverse-longitudinal spin polarizability $\delta_{LT}$, and also extend the coverage of the polarizability $\bar{d_2}$ to very low $Q^2$ for the first time. These results were extracted from moments of the structure function $g_2$, a quantity which characterizes the internal spin structure of the proton. Our experiment ran at Jefferson Lab using a polarized electron beam and a polarized solid ammonia (NH$_3$) target. The $\delta_{LT}$ polarizability has remained a challenging quantity for $\chi$PT to reproduce, despite its reduced sensitivity to higher resonance contributions; recent competing calculations still disagree with each other and also diverge from the measured neutron data at very low $Q^2$. Our proton results provide discriminating power between existing calculations, and will help provide a better understanding of this strong QCD regime.

Human error contributes to information system losses. Exposure to significant risk will continue and is not effectively addressed with conventional training. Broader strategy that addresses the social system is recommended. Such strategies have been successfully developed in industrial settings to deal with workplace hazards that are functionally similar to cyber loss. Four of these strategies are reviewed and found to be relevant to the needs of the IT-enabled organization in mitigating cyber security risks. These strategies are not consistent with each other or uniformly applicable, however, and would need to be adapted to contemporary knowledge work settings and used cautiously. Long-term institutionalization and development of organizational practices pose further challenges. While a holistic, sociotechnical systems (STS) approach to cyber security requires significant effort, IT-enabled organizations, as industrial organizations before them, will realize the effort is justified.

The Patient Protection and Affordable Care Act (PPACA, 2010) and the Institute of Medicine's (IOM, 2011) Future of Nursing report have prompted changes in the U.S. health care system. This has also stimulated a new direction of thinking for the profession of nursing. New payment and priority structures, where value is placed ahead of volume in care, will start to define our health system in new and unknown ways for years. One thing we all know for sure: we cannot afford the same inefficient models and systems of care of yesterday any longer. The Data-Driven Model for Excellence in Staffing was created as the organizing framework to lead the development of best practices for nurse staffing across the continuum through research and innovation. Regardless of the setting, nurses must integrate multiple concepts with the value of professional nursing to create new care and staffing models. Traditional models demonstrate that nurses are a commodity. If the profession is to make any significant changes in nurse staffing, it is through the articulation of the value of our professional practice within the overall health care environment. This position paper is organized around the concepts from the Data-Driven Model for Excellence in Staffing. The main concepts are: Core Concept 1: Users and Patients of Health Care, Core Concept 2: Providers of Health Care, Core Concept 3: Environment of Care, Core Concept 4: Delivery of Care, Core Concept 5: Quality, Safety, and Outcomes of Care. This position paper provides a comprehensive view of those concepts and components, why those concepts and components are important in this new era of nurse staffing, and a 3-year challenge that will push the nursing profession forward in all settings across the care continuum. There are decades of research supporting various changes to nurse staffing. Yet little has been done to move that research into practice and operations. While the primary goal of this position paper is to generate research and innovative thinking about nurse staffing across all health care settings, a second goal is to stimulate additional publications. This includes a goal of at least 20 articles in Nursing Economic$ on best practices in staffing and care models from across the continuum over the next 3 years.

The aim of this document is to provide a clear and concise account of the evidence regarding efficacy or harm for various methods available to prevent and manage venous thromboembolism (VTE).

The physics case and an experimental overview of the MOLLER (Measurement Of a Lepton Lepton Electroweak Reaction) experiment at the 12 GeV upgraded Jefferson Lab are presented. A highlight of the Fundamental Symmetries subfield of the 2007 NSAC Long Range Plan was the SLAC E158 measurement of the parity-violating asymmetry $A_{PV}$ in polarized electron-electron (M��ller) scattering. The proposed MOLLER experiment will improve on this result by a factor of five, yielding the most precise measurement of the weak mixing angle at low or high energy anticipated over the next decade. This new result would be sensitive to the interference of the electromagnetic amplitude with new neutral current amplitudes as weak as $\sim 10^{-3}\cdot G_F$ from as yet undiscovered dynamics beyond the Standard Model. The resulting discovery reach is unmatched by any proposed experiment measuring a flavor- and CP-conserving process over the next decade, and yields a unique window to new physics at MeV and multi-TeV scales, complementary to direct searches at high energy colliders such as the Large Hadron Collider (LHC). The experiment takes advantage of the unique opportunity provided by the upgraded electron beam energy, luminosity, and stability at Jefferson Laboratory and the extensive experience accumulated in the community after a round of recent successfully completed parity-violating electron scattering experiments

Tests for peripheral vascular diseases tests for cerebrovascular diseases renal artery stenosis intestinal ischaemia aneurysms venous diseases other vascular problems, malformations and tumours surveillance vascular screening other applications of noninvasive vascular investigations other nonvascular applications points to consider in noninvasive investigations.

Objectives: To estimate the economic efficiency of tight blood pressure control, with angiotensin converting enzyme inhibitors or beta blockers, compared with less tight control in hypertensive patients with type 2 diabetes. Design: Cost effectiveness analysis incorporating within trial analysis and estimation of impact on life expectancy through use of the within trial hazards of reaching a defined clinical end point. Use of resources driven by trial protocol and use of resources in standard clinical practice were both considered. Setting: 20 hospital based clinics in England, Scotland, and Northern Ireland. Subjects: 1148 hypertensive patients with type 2 diabetes from UK prospective diabetes study randomised to tight control of blood pressure (n=758) or less tight control (n=390). Main outcome measure: Cost effectiveness ratios based on (a) use of healthcare resources associated with tight control and less tight control and treatment of complications and (b) within trial time free from diabetes related end points, and life years gained. Results: Based on use of resources driven by trial protocol, the incremental cost effectiveness of tight control compared with less tight control was cost saving. Based on use of resources in standard clinical practice, incremental cost per extra year free from end points amounted to £1049 (costs and effects discounted at 6% per year) and £434 (costs discounted at 6% per year and effects not discounted). The incremental cost per life year gained was £720 (costs and effects discounted at 6% per year) and £291 (costs discounted at 6% per year and effects not discounted). Conclusions: Tight control of blood pressure in hypertensive patients with type 2 diabetes substantially reduced the cost of complications, increased the interval without complications and survival, and had a cost effectiveness ratio that compares favourably with many accepted healthcare programmes.

The Proton Radius Puzzle is the inconsistency between the proton radius determined from muonic hydrogen and the proton radius determined from atomic hydrogen level transitions and ep elastic scattering. No generally accepted resolution to the Puzzle has been found. Possible solutions generally fall into one of three categories: the two radii are different due to novel beyond-standard-model physics, the two radii are different due to novel aspects of nucleon structure, and the two radii are the same, but there are underestimated uncertainties or other issues in the ep experiments. The MUon proton Scattering Experiment (MUSE) at the Paul Scherrer Institut is a simultaneous measurement of ��^+ p and e^+ p elastic scattering, as well as ��^- p and e^- p elastic scattering, which will allow a determination of the consistency of the ��p and the ep interactions. The differences between + and - charge scattering are sensitive to two-photon exchange effects, higher-order corrections to the scattering process. The slopes of the cross sections as Q^2 -> 0 determine the proton "radius". We plan to measure relative cross sections at a typical level of a few tenths of a percent, which should allow the proton radius to be determined at the level of ~0.01 fm, similar to previous ep measurements. The measurements will test several possible explanations of the proton radius puzzle, including some models of beyond-standard-model physics, some models of novel hadronic physics, and some issues in the radius extraction from scattering data., 22 pages, 3 figures. This is a "White Paper" on the Paul Scherrer Institut MUSE experiment. Fixed references in version 2. Author list corrections

We propose a new precision measurement of parity-violating electron scattering on the proton at very low Q^2 and forward angles to challenge predictions of the Standard Model and search for new physics. A unique opportunity exists to carry out the first precision measurement of the proton's weak charge, $Q_W =1 - 4\sin^2\theta_W$. A 2200 hour measurement of the parity violating asymmetry in elastic ep scattering at Q^2=0.03 (GeV/c)^2 employing 180 $\mu$A of 85% polarized beam on a 35 cm liquid Hydrogen target will determine the proton's weak charge with approximately 4% combined statistical and systematic errors. The Standard Model makes a firm prediction of $Q_W$, based on the running of the weak mixing angle from the Z0 pole down to low energies, corresponding to a 10 sigma effect in this experiment., Comment: Proposal to Jefferson Lab Program Advisory Committee, December 2007. 93 pages, 44 figures. Uploaded here so a permanent copy is available, and for other papers to use arXiv version as reference First four authors are the spokespersons

Thrombophilia is the term now used to describe predisposition to increased risk of venous and occasionally arterial thromboembolism due to hematological abnormalities. It can be a multifactorial disorder where congenital defects of anticoagulant or procoagulant factors may be combined with acquired hematological abnormalities. It should be considered in patients with a documented unexplained thrombotic episode or a positive family history. The aim of this document is to provide guidelines for investigation and management of patients with thrombophilia in the presence or absence of venous thromboembolism (VTE).

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Urothelial cell carcinoma of the bladder (UCC) is a common disease often\ud characterized by FGFR3 dysregulation. Whilst upregulation of this oncogene occurs\ud most frequently in low-grade non-invasive tumors, recent data reveal increased\ud FGFR3 expression characterizes a common sub-type of invasive UCC sharing molecular\ud similarities with breast cancer. These similarities include upregulation of the FOXA1\ud transcription factor and reduced expression of microRNAs-99a/100. We have\ud previously identified direct regulation of FGFR3 by these two microRNAs and now\ud search for further targets. Using a microarray meta-database we find potential FOXA1\ud regulation by microRNAs-99a/100. We confirm direct targeting of the FOXA1 3’UTR\ud by microRNAs-99a/100 and also potential indirect regulation through microRNA-485-\ud 5p/SOX5/JUN-D/FOXL1 and microRNA-486/FOXO1a. In 292 benign and malignant\ud urothelial samples, we find an inverse correlation between the expression of FOXA1\ud and microRNAs-99a/100 (r=-0.33 to -0.43, p

There are excellent guidelines for clinicians to manage venous diseases but few reviews to assess their hemodynamic background. Hemodynamic concepts that evolved in the past have largely remained unchallenged in recent decades, perhaps due to their often complicated nature and in part due to emergence of new diagnostic techniques. Duplex ultrasound scanning and other imaging techniques which evolved in the latter part of the 20th century have dominated investigation. They have greatly improved our understanding of the anatomical patterns of venous reflux and obstruction. However, they do not provide the physiological basis for understanding the hemodynamics of flow, pressure, compliance and resistance. Hemodynamic investigations appear to provide a better correlation with post-treatment clinical outcome and quality of life than ultrasound findings. There is a far better prospect for understanding the complete picture of the patient's disability and response to management by combining ultrasound with hemodynamic studies. Accordingly, at the instigation of Dr Angelo Scuderi, the Union Internationale de Phlebologie (UIP) executive board commissioned a large number of experts to assess all aspects of management for venous disease by evidence-based principles. These included experts from various member societies including the European Venous Forum (EVF), American Venous Forum (AVF), American College of Phlebology (ACP) and Cardiovascular Disease Educational and Research Trust (CDERT). Their aim was to confirm or dispel long-held hemodynamic principles and to provide a comprehensive review of venous hemodynamic concepts underlying the pathophysiology of lower limb venous disorders, their usefulness for investigating patients and the relevant hemodynamic changes associated with various forms of treatment. Chapter 1 is devoted to basic hemodynamic concepts and normal venous physiology. Chapter 2 presents the mechanism and magnitude of hemodynamic changes in acute deep vein thrombosis indicating their pathophysiological and clinical significance. Chapter 3 describes the hemodynamic changes that occur in different classes of chronic venous disease and their relation to the anatomic extent of disease in the macrocirculation and microcirculation. The next four chapters (Chapters 4-7) describe the hemodynamic changes resulting from treatment by compression using different materials, intermittent compression devices, pharmacological agents and finally surgical or endovenous ablation. Chapter 8 discusses the unique hemodynamic features associated with alternative treatment techniques used by the CHIVA and ASVAL. Chapter 9 describes the hemodynamic effects following treatment to relieve pelvic reflux and obstruction. Finally, Chapter 10 demonstrates that contrary to general belief there is a moderate to good correlation between certain hemodynamic measurements and clinical severity of chronic venous disease. The authors believe that this document will be a timely asset to both clinicians and researchers alike. It is directed towards surgeons and physicians who are anxious to incorporate the conclusions of research into their daily practice. It is also directed to postgraduate trainees, vascular technologists and bioengineers, particularly to help them understand the hemodynamic background to pathophysiology, investigations and treatment of patients with venous disorders. Hopefully it will be a platform for those who would like to embark on new research in the field of venous disease.

A method for the laboratory culture of the Queensland fruit-fly (Dacus tryoni (Frogg.� is described.