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This contribution aims at an understanding, at a molecular scale, of the state of CO2 molecules absorbed in glassy poly(ether imide) (PEI). This issue has been challenged by combining different approaches that tackle the problem from both the experimental and the theoretical viewpoints and providing a comprehensive physicochemical picture. In situ FTIR spectroscopy and gravimetry were exploited to gather relevant experimental information, while molecular dynamics (MD), density functional theory (DFT), and statistical thermodynamics approaches were used to model the behavior of the binary system at different scales. Based on the findings of FTIR spectroscopy and on DFT and MD calculations, it was determined that, among the possible interaction configurations, some are prevailing. In particular, the carbon atom of carbon dioxide molecules establishes relatively weak interactions prevalently with the carbonyl groups of PEI. A quantitative estimate of such interaction has been provided by MD calculations. The system was also analyzed using a lattice fluid model, specifically developed to deal with sorption of low molecular weight compounds in glassy polymers, that is rooted on statistical thermodynamics, determining the values of the isosteric heat of sorption and carbon-dioxide-polymer interaction energy. Finally, experimental data of CO2-PEI mutual diffusivity have been interpreted using a semiempirical theoretical model accounting for the effects of the penetrant concentration, of energy barriers associated with the occurrence of an effective diffusive jump, and of a thermodynamic factor.

The degradation of performances for solar thermal collectors is linked to the decrease of the absorber efficiency caused by diffusion process, strongly dependent on temperature. The Standard procedure for qualification of solar absorbers surface durability defines the absorber temperature frequency function as one of the necessary parameters to estimate the failure time for collectors, but it only refers to applications at low temperatures like domestic hot water production (DHW). Because of this deficiency of the Standard, in order to make aging predictions for selective solar absorbers mounted on Evacuated Flat Plate Collectors (EFPCs) used for Mid-Temperature applications (with stagnation temperature over 573 K), in this paper a procedure to reconstruct their specific temperature frequency function, considering the high thermal efficiency and stagnation temperature, is provided. A dynamic simulation model of a small plant with a TVP-Solar EFPC is implemented in Simulink environment to obtain the yearly absorber temperature history in operating conditions and experimental data are collected to obtain the temperature trend of the EFPC under stagnation. The absorber temperature frequency function valid for EFPCs is presented for different operating temperatures considering that stagnation occurs for 30 days every year, as the Standard prescribes. 30 days of stagnation in a year is an unrealistic assumption for thermal collectors used for industrial application and, in order to give an indication in this sense, the variation of aging parameters for different stagnation periods (fallowing periods) is also presented. Using the simulation model for service-time, experimental data for stagnation and assuming the exact fallowing period for the solar plant, a greater accuracy of EFPC failure time evaluation can be obtained.

Background: For children with inflammatory bowel disease (IBD), understanding their condition may lead to better outcomes. Knowledge assessment is imperative to identify where education may be required. An IBD knowledge assessment tool (IBD-KID2) is available in English; the aim of this study was to translate IBD-KID2 in to Italian and assess its validity/reliability among children with IBD. Methods: IBD-KID2 has fifteen items, scoring one point per correct answer. IBD-KID2 items were assessed for cultural comprehension/relevance by Italian gastroenterologists using a content validity index; those items with a maximum score proportion

Small-grain farming systems in Mediterranean climatic regions are characterized by poor quality soils, high climate variability, and resulting heavy agrochemical reliance. The adoption of Conservation Agriculture, based on minimum tillage, permanent soil cover, and crop rotations, has improved soil quality, enhanced crop productivity, and help mitigate financial risk. However, emerging issues that threaten sustainability, such as herbicide resistance, inputs costs rising disproportionately to product prices, and increasing climate variability and unpredictability, drive the need for innovation in small-grain Mediterranean-based CA systems. The aim of the review was to evaluate a set of agroecological practices which constitute a Regenerative Agriculture (RA) concept, for their potential to address these challenges from a soil quality, crop productivity and whole-farm economics perspective. Organic soil amendments derived from agro-wastes, offer promising perspectives for supplying appropriate quantities of nutrients to reduce or replace mineral fertilisers and offset their economic and agroecological costs. Although the viability of microbial bioeffectors in small-grain agroecosystems was largely under question, non-microbial bioeffectors and certain combination options represent more efficient and cost-effective uses of this technology. Their widely reported abiotic stress priming functions and crop productivity enhancement under poor growing conditions may improve yield stability and financial resilience in small-grain Mediterranean CA systems. Finally, multi-species cover crops subjected to adaptive multi-paddock (AMP) grazing as a phase within the crop rotation may reduce weed pressure, enhance soil multi-functionality, and resilience against environmental stresses. To validate the potential of these technologies in Mediterranean small-grain systems, more long-term and context-specific research is called for.

The combination of elotuzumab, lenalidomide, and dexamethasone (EloRd) enhanced the clinical benefit over Rd with a manageable toxicity profile in the ELOQUENT-2 trial, leading to its approval in relapsed/refractory multiple myeloma (RRMM). The present study is a 3-year follow-up update of a previously published Italian real-life RRMM cohort of patients treated with EloRd. This revised analysis entered 319 RRMM patients accrued in 41 Italian centers. After a median follow-up of 36 months (range 6-55), 236 patients experienced disease progression or died. Median progression-free survival (PFS) and overall survival (OS) were 18.4 and 34 months, respectively. The updated multivariate analyses showed a significant reduction of PFS and OS benefit magnitude only in cases with ISS stage III. Major adverse events included grade 3/4 neutropenia (18.5%), anemia (15.4%), lymphocytopenia (12.5%), and thrombocytopenia (10.7%), while infection rates and pneumonia were 33.9% and 18.9%, respectively. No new safety signals with longer follow-up have been observed. Of 319 patients, 245 (76.7%) reached at least a partial remission. A significantly lower response rate was found in patients previously exposed to lenalidomide. In conclusion, our study confirms that EloRd is a safe and effective regimen for RRMM patients, maintaining benefits across multiple unfavorable subgroups. This article is protected by copyright. All rights reserved.

We report data on survival and complications for a longitudinal cohort of 709 transfusion-dependent β-thalassemia major patients (51.1% males) born between 1970 and 1997 and followed through 2020 at seven major centers in Italy. Overall survival probability at 30 years was 83.6% (95%CI: 78.5-89.1) in the oldest birth cohort (1970-1974) compared with 93.3% (95%CI: 88.6-98.3) in the youngest birth cohort (1985-1997) (p = 0.073). Females showed better survival than males (p = 0.022). There were a total of 93 deaths at a median age of 23.2 years with the most frequent disease-related causes being heart disease (n = 53), bone marrow transplant (BMT) complication (n = 10), infection (n = 8), liver disease (n = 4), cancer (n = 3), thromboembolism (n = 2) and severe anemia (n = 1). There was a steady decline in the number of deaths due to heart disease from the year 2000 onwards and no death from BMT was observed after the year 2010. A progressive decrease in the median age of BMT was observed in younger birth cohorts (p 0.001). A total of 480 (67.7%) patients developed ≥1 complication. Patients in younger birth cohorts demonstrated better complication-free survival (p 0.001) which was comparable between sexes (p = 0.230). Independent risk factors for death in multivariate analysis included heart disease (HR: 4.63, 95%CI: 1.78-12.1, p = 0.002), serum ferritin1000 ng/mL (HR: 15.5, 95%CI: 3.52-68.2, p 0.001), male sex (HR: 2.75, 95%CI: 0.89-8.45, p = 0.078), and splenectomy (HR: 6.97, 95%CI: 0.90-54.0, p 0.063). Survival in patients with β-thalassemia major continues to improve with adequate access to care, best practice sharing, continued research, and collaboration between centers.

Introduction: Interferon regulatory factor 4 (IRF4) is a transcriptional factor with a key role in the modulation of inflammation and immune surveillance. The IRF4 gene is downregulated in Philadelphia-negative myeloproliferative neoplasms, and its expression is associated with prognosis and response to treatment. Methods: We evaluated the IRF4 expression kinetics during tyrosine kinase inhibitor (TKI) treatment in a cohort of 116 chronic myeloid leukemia (CML) patients to elucidate its role in the disease course. Results: A relationship between the IRF4 expression and the disease burden was observed at various disease stages. A correlation analysis between the International Scale (IS) and IRF4 values confirmed this close association. A significant increase is detected after 3 months of TKI treatment. Patients achieving an early molecular response (EMR) had higher IRF4 values at both diagnosis and after 3 months of therapy as compared to those failing the EMR target. Patients achieving treatment-free remission did not show IRF4 fluctuations during monitoring, while a decreased IRF4 expression emerged at the time of molecular relapse. Conclusion: Our data seem to confirm the relevance of IRF4 in the pathogenesis of CML, suggesting a pivotal role at the disease onset and a predictive value during the CML course.

This paper uses an intersectional framework to account for the degree to which race, when intersecting gender, relates to teachers’ evaluations of US elementary school children over time. Drawing on longitudinal data from the 2011 Early Childhood Longitudinal Study-Kindergarten cohort, we employ growth curve modeling to study descriptive trends in teacher perceptions of student behavior from kindergarten through fifth grade. We find that educators’ perceptions of White, Asian American, and Latinx girls increase over time, while their perceptions of Black girls remain flat. Meanwhile, a different longitudinal trend emerges among boys. Although teachers’ views of Black boys decrease over time, their views of other boys increase to the levels of Black girls, or higher, by the end of fifth grade. This analysis reveals how teachers’ perceptions coalesce into an emerging hierarchy that—by the end of fifth grade—most sharply contrasts the behavior of Asian American girls and Black boys. Our intersectional approach and the theoretical framework informing it underscore the limits to considering how educators distinguish students by gender or race alone. Together, gender and race more fully account for differences in how educators perceive student behavior over time.

The metachronic onset of diffuse large B-cell lymphoma (DLBCL) after classic Hodgkin lymphoma (cHL) is a rare event affecting patients’ outcomes. However, although several studies have investigated the prognostic role of this event, little is known about a hypothetical common origin of the two different neoplastic cells. Aims: To investigate a possible relationship between DLBCL and cHL, in this retrospective study of 269 patients with newly diagnosed cHL treated at Bari University Hospital (Italy) between 2007 and 2020, we analyzed data from 4 patients (3 male and 1 female) with cHL who subsequently developed DLBCL. Methods: Gene expression profile analysis, assessed by NanoString Lymphoma Subtype Assay, was performed to identify the cell of origin in the DLBCL cases, in addition to Hans’s algorithm. Results: Using Hans’s algorithm, all DLBCL cases showed a germinal center-B-Cell subtype. The gene expression profile evaluated by the NanoString Lymphoma Subtype Assay revealed two cases of the GCB molecular subtype, while the others were unclassified. After first-line chemotherapy, 1 patient achieved complete remission, 3 were non-responders (2 died of lymphoma within 6 months, whereas the other achieved complete remission after autologous and allogeneic stem cell transplantation and is still alive). Conclusions: The origin of the second neoplastic cell in patients with DLBCL with a previous history of cHL remains controversial, although the different immunophenotypic characteristics suggest that it may mainly arise de novo in a subject with a possible individual predisposition to develop lymphoid neoplasms.

Lymphoproliferative diseases arise when the physiological mechanisms that control the proliferation of T and B lymphocytes are disrupted, resulting in an uncontrolled and autonomous increase in immune cells leading to lymphocytosis and lymphadenopathy, and often to the involvement of extranodal sites. The differential diagnosis of malignant T cell tumors involves other neoplasms and non-clonal T cell proliferations. Immunological markers are essential, as a first step, to distinguish between T-cell and non-T-cell disorders. It must be established based on the configuration of the genes of the TCR chain to rule out that the picture is not reactive to other underlying diseases. This clinical review and accompanying case reports highlight the diagnostic challenges associated with indolent lymphoproliferative T-cell disorders, which in many cases may represent the clinical manifestation of a single disease. Particularly we focus on gastrointestinal manifestations that could be expression either of lymphoproliferative disorder either of autoimmune disease either of both. The correct interpretation of the different clinical situations can help in the diagnostic and therapeutic process.

Introduction The NHS Abdominal Aortic Aneurysm Screening Programme (NAAASP) was established nationally to reduce the number of deaths caused by ruptured AAA. NAAASP invites all men in their 65th year for a simple abdominal ultrasound scan. Across the country uptake to the programme varies greatly. The aim of this study is to determine the impact of deprivation on local screening programme attendance. Methods The attendance for patients invited to screening within the Leicester, Leicestershire and Rutland screening NAAASP programme between the years 2016 and 2021 was compared to indices of multiple deprivation (IMD) (derived from their Lower Layer Super Output Area (LSOA) for each patient). Multiple logistic regression was used to determine the most significant component contributing to the IMD score. Results 28,730 men in total were invited to attend. Mean IMD for those that attended screening was 15.6 versus 20.6 for non-attenders (P value Conclusion In line with the contemporary medical literature, social deprivation affects the uptake of the local National Abdominal Aortic Aneurysm Screening Programme (NAAASP). Health deprivation and disability, Outdoor living environment and adult education domains are most contributory to non-attendance.

Background Current data on dual biologic or small molecules therapy in children are limited. The aim of the study was to evaluate the effectiveness and safety of dual therapy in paediatric patients with IBD. Methods This was a retrospective multicenter study from 14 centers affiliated with the IBD interest and Porto groups of ESPGHAN. We included children with IBD who were treated with combination of biologic agents or biologic and small molecule, with at least 3 months of follow-up under this therapy. Demographic, clinical, laboratory, endoscopic and imaging data were collected. Adverse events were recorded. All analyses were done in the intention-to-treat population. Children that discontinued therapy were considered treatment failures and were imputed for non-response, while missing data was imputed according to the last observation carried forward method. Results Sixty-two children [35 Crohn's disease (CD), 27 ulcerative colitis (UC)], with a median age of 15.5 (IQR 13.1-16.8) years and disease duration of 3.8 (IQR 2.5-6.1) years were included. All children failed previous biologics and 47 (76%) failed at least two biologic agents. The dual therapy included anti-TNF agent and vedolizumab in 30 children (48%), anti-TNF and ustekinumab in 21 children (34%), vedolizumab and ustekinumab in 8 children (13%), and tofacitinib and other biologics in 3 children (5%). Clinical remission was observed in 21 (35%), 30 (50%) and 38 (63%) children at 3, 6 and 12 months, respectively. Of 27 children who were treated with corticosteroids at baseline, 20 (74.1%) were weaned within 3 months after the initiation of dual therapy. At 12 months of follow up, normalization of C-reactive protein and decrease in fecal calprotectin to < 250 mcg/g were achieved in 75% and 64%, respectively. Endoscopic and transmural healing were observed in 2/23 (9%) and 5/16 (31%) children, respectively. Male sex and diagnosis of UC were associated with higher likelihood of clinical remission (p=0.017 and p=0.020, respectively). Adverse events were reported in 29 (47%) children. While most adverse event were mild, 8 were regarded as serious and 6 (10%) led to discontinuation of dual therapy. The serious adverse events included infusion reaction to infliximab, fatigue and headache following vedolizumab infusion, severe skin eruptions (3 patients), cellulitis and skin abscess, elevated liver enzymes and deep vein thrombosis. Conclusion Dual biologic or small molecules therapy may be effective in children with otherwise refractory IBD. The risk of serious adverse events should be considered before recommending dual therapy.

In this article we will discuss the first Coronavirus (Covid-19) lockdown and its immediate aftermath on the lives of migrant sex workers living and working in France, drawing on original interviews gathered between May and July 2020. Since 2016 in France, sex workers have worked under the so-called Swedish model legal framework criminalising the demand of sexual services. This has meant that sex workers, both migrant and non-migrant, have had to find various strategies to continue working within a criminalised environment infringing upon their rights and safety. Research in the French context has largely shown that the introduction of the Swedish model increased the financial precarity and impacted in significant, detrimental ways the physical and mental health of sex workers (Le Bail & Giametta 2018). In the context of the existing hardship to which migrant sex workers were exposed under this repressive regime in France, this article investigates if and how the law enforcement and emergency measures around the Covid-19 crisis aggravated their already precarious living conditions. Our analysis here demonstrates that both institutional racism (e.g., government policies and law enforcement targeting racialized migrants) and interpersonal stigmatisation (e.g., poor treatment and stereotyping by clients and civil society) must be combated to reduce the discrimination against migrant sex workers that is amplified in times of crisis.

While political science has probed the ideological, political, economic and even psychological motivations behind the drive to war, socialist theory has made a unique contribution by highlighting the relationship between the development of capitalism and war. There’s a long and rich tradition of the Left’s opposition to militarism that dates back to the International Working Men’s Association. It is an excellent resource for understanding the origins of war under capitalism and helping leftists maintain our clear opposition to it. In this article, the author examines the position of all the main currents (socialist, socialdemocratic, communist, anarchist and feminist) intellectuals (Engels, Kropotkin, Malatesta, Jaurès, Luxemburg, Lenin, Mao and Khrushchev) of the Left on the war and its different declinations (‘war of defence’, ‘just war’, ‘revolutionary war’).

Not available.

Pembuatan Charger Station dengan mengimplementasikan Buck-Boost Converter dengan sumber energi yang dihasilkan panel surya bertujuan untuk memudahkan masyarakat pada saat berwisata ke suatu tempat, terutama wisata outdoor karena kurang tersedianya tempat untuk pengisian baterai pada Handphone. Dalam artikel ini akan dibahas suatu perancangan dan Simulasi Sistem Charging Station Dengan mempertimbangkan Tegangan Masuk pada Buck-Boost Converter. Pada perancangan sistem ini memperhatikan buck-boost converter untuk dapat memberikan tegangan yang masuk kedalam Aki agar bisa mengecas dan bisa mengeluarkan tegangan yang diinginkan. Sistem ini dirancang dan disimulasikan dengan program proteus dengan tegangan paling rendah sebesar 9.5 Volt sampai tegangan paling tinggi sebesar 18 Volt. Tegangan yang diinginkan dari makalah ini sebesar 13.6 Volt. Hasil dari penelitian ini menunjukkan bahwa berapapun nilai tegangan masuk pada rangkaian dalam rentang 9.5 - 18 Volt bisa mengeluarkan tegangan sebesar 13.6 Volt dengan nilai rata-rata error sebesar 0.021 Volt.

The understanding of clonal hematopoiesis (CH) and its features is rapidly evolving in step with the spread of sequencing techniques. Indeed, CH detection is now an emerging aspect in clinical practice. The awareness of CH intersects with consolidated diagnostic paths, thus exposing 'grey zone' circumstances under the magnifying lens of clinicians. The interpretation of genomic data poses, in some cases, a true clinical challenge, sometimes further complicating the route to diagnosis. The line separating different entities is thin. The present work aims to review some of these challenging situations to help clinicians keep their balance along this tightrope.

Background: Uruguay was the first country in the world to explicitly authorize the personal cultivation of cannabis in 2013 within a comprehensive market regulation model. This policy development provides a unique opportunity to gauge the first impact of cannabis regulation on domestic cannabis growing and to have a more accurate picture of the characteristics of cannabis growers, a topic largely neglected by previous research in the country. Method: The Survey on Regulated Cannabis in Uruguay was conducted between October and December of 2017 to a random sample of the population between 15 and 65 years of age ( n = 2,181). Using face-to-face interviews, the survey asked about the use of cannabis (forms, amounts, access, motivations, etc.) and other drugs, included a sociodemographic module, and a specific section on domestic cultivation ( n = 213). The questions were formulated to ensure comparability with previous international surveys (ICCQ-GCCRC) conducted in 13 industrialized countries. Results: After regulation, the type of product consumed in Uruguay changed completely, with a significant increase in the preference for domestically grown cannabis. Most growers are experienced and frequent cannabis users. In the comparison with other countries, important similarities appear, as the quantity produced or the ages of growers, as well as relevant differences. While there is a predominance of men, a higher number of women got involved in growing after the law was adopted. Most cannabis is produced outdoors and with low costs per harvest. Conclusions: In a context of scarcity of legally sold cannabis, both registered and unregistered cannabis personal growing increased in Uruguay, though mostly through “experimental” attempts and motivations.

Na primeira parte da década de 1860, o interesse jornalístico e escolar de Marx na diplomacia e na política internacional o levaram a voltar sua atenção para dois importantes eventos históricos. O primeiro foi o estouro da guerra civil americana, quando sete estados escravocratas declararam sua secessão dos EUA. O segundo foi o levante do povo polonês contra a ocupação pela Rússia. A análise de Marx desses eventos históricos também influenciou seu compromisso político através da Associação Internacional dos Trabalhadores. Este artigo examina como os estudos de Marx sobre a guerra civil nos EUA e a luta por independência da Polônia foram relevantes tanto para seu desenvolvimento teórico quanto para seu engajamento político. Através dessas investigações Marx compreendeu dinâmicas matizadas em funcionamento, permitindo a ele sugerir intervenções internacionalistas funcionais para as organizações da classe trabalhadora.

Background Current data on dual biologic therapy in children are limited. This multicenter study aimed to evaluate the effectiveness and safety of dual therapy in pediatric patients with inflammatory bowel disease (IBD). Methods A retrospective study from 14 centers affiliated with the Pediatric IBD Interest and Porto Groups of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition. Included were children with IBD who underwent combinations of biologic agents or biologic and small molecule therapy for at least 3 months. Demographic, clinical, laboratory, endoscopic, and imaging data were collected. Adverse events were recorded. Results Sixty-two children (35 Crohn’s disease, 27 ulcerative colitis; median age 15.5 [interquartile range, 13.1-16.8] years) were included. They had all failed previous biologic therapies, and 47 (76%) failed at least 2 biologic agents. The dual therapy included an anti-tumor necrosis factor agent and vedolizumab in 30 children (48%), anti-tumor necrosis factor and ustekinumab in 21 (34%) children, vedolizumab and ustekinumab in 8 (13%) children, and tofacitinib with a biologic in 3 (5%) children. Clinical remission was observed in 21 (35%), 30 (50%), and 38 (63%) children at 3, 6, and 12 months, respectively. Normalization of C-reactive protein and decrease in fecal calprotectin to Conclusions Dual biologic therapy may be effective in children with refractory IBD. The potential efficacy should be weighed against the risk of serious adverse events.

Supplementary Figures S1 to S11. Supplementary Figure S1: Schematic illustration of the approach used to create trastuzumab-maytansinoid ADC resistant cell lines. Supplementary Figure S2: Structures of payloads and ADCs. Supplementary Figure S3: 361-TM-resistant cells show differential responses to ADCs with modified linkers, payloads, and antibodies. Supplementary Figure S4: Ectoptic expression of Her2 in JIMT1-TM cells rescues sensitivity to TM-ADC. Supplementary Figure S5: Cell surface proteomic profiling of 361-TM resistant cells, with evidence of increased ABCC1. Supplementary Figure S6: Knockdown of ABCC1 (MRP1) in 361-TM cells sensitizes to ADCs. Supplementary Figure S7: Endosomal and lysosomal proteins altered in JIMT1-TM resistant cells as determined by proteomic profiling. Supplementary Figure S8: Immunoblot verification of elevated surface-associated proteins in JIMT1-TM resistant cells. Supplementary Figure S9: Co-localization analyses of ADC and lysosome via live-cell imaging. Supplementary Figure S10: Altered trafficking in JIMT1-TM cells are specific to TM-ADC and not transferrin receptor antibody. Supplementary Figure S11: LC-MRM analyses of released products from ADCs incubated with parental and resistant cell lines.

Supplementary Methods, Table S1 S2, and Figure Legends. Supplementary Table S1: Properties of cell lines made resistant to TM-conjugate. Supplementary Table S2: Relative resistance of selected free payloads and Cys-capped-released species in H69 (no ABCC1) and H69AR (high ABCC1 expressing) cell lines.

PDF file - 59K, Forty-seven genes differentially expressed in t(11;14), t(4;14) and MAF-associated translocations group.

Figure S4. Landmark analysis (landmark point at 18 months) of OS (A, C) and PFS2 (B, D) in patients with multiple myeloma stratified according to ER18

Figure S5. OS from relapse (A) and 2nd PFS (B) in patients with ER18 vs. late relapse (LR)

PDF file - 395K, Expression plots and functional annotations charts of miRNAs identified as differentially expressed between pPCL and MM patients.

Supplementary Methods, Table S1, and Figure S1