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2. Cross-correlation of DES Y3 lensing and ACT/Planck thermal Sunyaev Zel’dovich Effect I:Measurements, systematics tests, and feedback model constraints

Author

M. Gatti, S. Pandey, E. Baxter, J. C. Hill, E. Moser, M. Raveri, X. Fang, J. DeRose, G. Giannini, C. Doux, H. Huang, N. Battaglia, A. Alarcon, A. Amon, M. Becker, A. Campos, C. Chang, R. Chen, A. Choi, K. Eckert, J. Elvin-Poole, S. Everett, A. Ferte, I. Harrison, N. Maccrann, J. Mccullough, J. Myles, A. Navarro Alsina, J. Prat, R.P. Rollins, C. Sanchez, T. Shin, M. Troxel, I. Tutusaus, B. Yin, T.

Published
2022
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3. ANTARES upper limits on the multi-TeV neutrino emission from the GRBs detected by IACTs

Author

ANTARES Collaboration, Albert, A., Andr��, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J. -J., Aublin, J., Baret, B., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bissinger, M., Boumaaza, J., Bouta, M., Bouwhuis, M. C., Br��nza��, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Carretero, V., Celli, S., Chabab, M., Chau, T. N., Moursli, R. Cherkaoui El, Chiarusi, T., Circella, M., Coleiro, A., Colomer-Molla, M., Coniglione, R., Coyle, P., Creusot, A., D��az, A. F., de Wasseige, G., Deschamps, A., Distefano, C., Di Palma, I., Domi, A., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., Khayati, N. El, Enzenh��fer, A., Ettahiri, A., Fermani, P., Ferrara, G., Filippini, F., Fusco, L., Garc��a, R., Gay, P., Glotin, H., Gozzini, R., Graf, K., Guidi, C., Hallmann, S., van Haren, H., Heijboer, A. J., Hello, Y., Hern��ndez-Rey, J. J., H����l, J., Hofest��dt, J., Huang, F., Illuminati, G., James, C. W., Jisse-Jung, B., de Jong, M., de Jong, P., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Breton, R. Le, Lef��vre, D., Leonora, E., Levi, G., Lincetto, M., Lopez-Coto, D., Loucatos, S., Maderer, L., Manczak, J., Marcelin, M., Margiotta, A., Marinelli, A., Mart��nez-Mora, J. A., Mazzou, S., Melis, K., Migliozzi, P., Moser, M., Moussa, A., Muller, R., Nauta, L., Navas, S., Nezri, E., Nu��ez-Casti��eyra, A., O'Fearraigh, B., Organokov, M., P��v��la��, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Pieterse, C., Poir��, C., Popa, V., Pradier, T., Randazzo, N., Reck, S., Riccobene, G., S��nchez-Losa, A., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schnabel, J., Sch��ssler, F., Spurio, M., Stolarczyk, Th., Taiuti, M., Tayalati, Y., Thakore, T., Tingay, S. J., Vallage, B., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., Wilms, J., Zegarelli, A., Zornoza, J. D., Z����iga, J., Institut Pluridisciplinaire Hubert Curien (IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Laboratoire d'Informatique et Systèmes (LIS), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Institut méditerranéen d'océanologie (MIO), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, ANTARES, KM3NeT (IHEF, IoP, FNWI), ATLAS (IHEF, IoP, FNWI), IHEF (IoP, FNWI), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre Tecnològic de Vilanova i la Geltrú, Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques, Albert A., Andre M., Anghinolfi M., Anton G., Ardid M., Aubert J.-J., Aublin J., Baret B., Basa S., Belhorma B., Bertin V., Biagi S., Bissinger M., Boumaaza J., Bouta M., Bouwhuis M.C., Br nzas H., Bruijn R., Brunner J., Busto J., Capone A., Caramete L., Carr J., Carretero V., Celli S., Chabab M., Chau T.N., Cherkaoui El Moursli R., Chiarusi T., Circella M., Coleiro A., Colomer-Molla M., Coniglione R., Coyle P., Creusot A., Diaz A.F., De Wasseige G., Deschamps A., Distefano C., Di Palma I., Domi A., Donzaud C., Dornic D., Drouhin D., Eberl T., El Khayati N., Enzenhofer A., Ettahiri A., Fermani P., Ferrara G., Filippini F., Fusco L., Garcia R., Gay P., Glotin H., Gozzini R., Graf K., Guidi C., Hallmann S., Van Haren H., Heijboer A.J., Hello Y., Hernandez-Rey J.J., Hossl J., Hofest dt J., Huang F., Illuminati G., James C.W., Jisse-Jung B., De Jong M., De Jong P., Jongen M., Kadler M., Kalekin O., Katz U., Khan-Chowdhury N.R., Kouchner A., Kreykenbohm I., Kulikovskiy V., Lahmann R., Le Breton R., Lef vre D., Leonora E., Levi G., Lincetto M., Lopez-Coto D., Loucatos S., Maderer L., Manczak J., Marcelin M., Margiotta A., Marinelli A., Martinez-Mora J.A., Mazzou S., Melis K., Migliozzi P., Moser M., Moussa A., Muller R., Nauta L., Navas S., Nezri E., Nuez-Castieyra A., O'Fearraigh B., Organokov M., Pavalas G.E., Pellegrino C., Perrin-Terrin M., Piattelli P., Pieterse C., Poir C., Popa V., Pradier T., Randazzo N., Reck S., Riccobene G., Sanchez-Losa A., Samtleben D.F.E., Sanguineti M., Sapienza P., Schnabel J., Schussler F., Spurio M., Stolarczyk T., Taiuti M., Tayalati Y., Thakore T., Tingay S.J., Vallage B., Van Elewyck V., Versari F., Viola S., Vivolo D., Wilms J., Zegarelli A., Zornoza J.D., and Zuiga J.

Subjects
Astrofísica, electron, dimension: 3, Astrophysics, 01 natural sciences, neutrino: flux, IceCube, Raigs gamma, HESS, optical, MAGIC (telescope), Physics, High Energy Astrophysical Phenomena (astro-ph.HE), photomultiplier, ultra high energy photons and neutrinos, Astrophysics::Instrumentation and Methods for Astrophysics, imaging, gamma ray: emission, neutrino: detector, Neutrino detector, Neutrino astronomy, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, Photomultiplier, particle acceleration, Astrophysics::High Energy Astrophysical Phenomena, Particle acceleration, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, gamma ray: burst, GLAST, neutrino astronomy, X-ray, gamma ray bursts theory, 0103 physical sciences, Ultra high energy photons and neutrinos, Cherenkov radiation, ANTARES, Gamma ray bursts theory, Telescopis, 010308 nuclear & particles physics, Gamma rays, Astronomy and Astrophysics, MAGIC, Afterglow, Cherenkov counter, electromagnetic, gamma ray: VHE, 13. Climate action, FISICA APLICADA, Física::Astronomia i astrofísica [Àrees temàtiques de la UPC], correlation, ultra high energy photons and neutrino, Gamma-ray burst, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Telescopes
Abstract

[EN] The first gamma-ray burst detections by Imaging Atmospheric Cherenkov Telescopes have been recently announced: GRB 190114C, detected by MAGIC, GRB 180720B and GRB 190829A, observed by H.E.S.S. A dedicated search for neutrinos in space and time coincidence with the gamma-ray emission observed by IACTs has been performed using ANTARES data. The search covers both the prompt and afterglow phases, yielding no neutrinos in coincidence with the three GRBs studied. Upper limits on the energetics of the neutrino emission are inferred. The resulting upper limits are several orders of magnitude above the observed gamma-ray emission, and they do not allow to constrain the available models., The authors acknowledge the financial support of the funding agencies: Centre National de la Recherche Scientifique (CNRS), Commissariat a l'energie atomique et aux energies alternatives (CEA), Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), LabEx UnivEarthS (ANR-10-LABX-0023 and ANR18-IDEX-0001), Region Ile-de-France (DIM-ACAV), Region Alsace (contrat CPER), Region Provence-Alpes-Cote d'Azur, Departement du Var and Ville de La Seyne-sur-Mer, France; Bundesministerium fur Bildung und Forschung (BMBF), Germany; Istituto Nazionale di Fisica Nucleare (INFN), Italy; Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; Council of the President of the Russian Federation for young scientists and leading scientific schools supporting grants, Russia; Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI), Romania; Ministerio de Ciencia e Innovacion (MCI) and Agencia Estatal de Investigacion: Programa Estatal de Generacion de Conocimiento (refs. PGC2018-096663-B-C41, -A-C42, -B-C43, -BC44) (MCI/FEDER), Severo Ochoa Centre of Excellence and MultiDark Consolider, Junta de Andalucia (ref. SOMM17/6104/UGR and A-FQM-053-UGR18), Generalitat Valenciana: Grisolia (ref. GRISOLIA/2018/119), Spain; Ministry of Higher Education, Scientific Research and Professional Training, Morocco. We also acknowledge the technical support of Ifremer, AIM and Foselev Marine for the sea operation and the CC-IN2P3 for the computing facilities.

Published
2020
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4. Measurement of the atmospheric $��_e$ and $��_��$ energy spectra with the ANTARES neutrino telescope

Author

Albert, A., Alves, S., Andr��, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J. -J., Aublin, J., Baret, B., Basa, S., Belhorma, B., Bendahman, M., Bertin, V., Biagi, S., Bissinger, M., Boumaaza, J., Bouta, M., Bouwhuis, M. C., Br��nza��, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Carretero, V., Celli, S., Chabab, M., Chau, T. N., Moursli, R. Cherkaoui El, Chiarusi, T., Circella, M., Coleiro, A., Colomer-Molla, M., Coniglione, R., Coyle, P., Creusot, A., D��az, A. F., de Wasseige, G., Deschamps, A., Distefano, C., Di Palma, I., Domi, A., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., Khayati, N. El, Enzenh��fer, A., Fermani, P., Ferrara, G., Filippini, F., Fusco, L., Garc��a, R., Gatelet, Y., Gay, P., Glotin, H., Gozzini, R., Graf, K., Guidi, C., Hallmann, S., van Haren, H., Heijboer, A. J., Hello, Y., Hern��ndez-Rey, J. J., H����l, J., Hofest��dt, J., Huang, F., Illuminati, G., James, C. W., Jisse-Jung, B., de Jong, M., de Jong, P., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Breton, R. Le, Lef��vre, D., Leonora, E., Levi, G., Lincetto, M., Lopez-Coto, D., Loucatos, S., Maderer, L., Manczak, J., Marcelin, M., Margiotta, A., Marinelli, A., Mart��nez-Mora, J. A., Melis, K., Migliozzi, P., Moser, M., Moussa, A., Muller, R., Nauta, L., Navas, S., Nezri, E., Nunez-Castineyra, A., O'Fearraigh, B., Organokov, M., P��, G. E., V��, La��, Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Pieterse, C., Poir��, C., Popa, V., Pradier, T., Randazzo, N., Reck, S., Riccobene, G., Greus, F. Salesa, Samtleben, D. F. E., S��nchez-Losa, A., Sanguineti, M., Sapienza, P., Schnabel, J., Schumann, J., Sch��ssler, F., Spurio, M., Stolarczyk, Th., Taiuti, M., Tayalati, Y., Thakore, T., Tingay, S. J., Vallage, B., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., Wilms, J., Zegarelli, A., Zornoza, J. D., and Z��niga, J.

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), High Energy Physics - Experiment (hep-ex), Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, FOS: Physical sciences, High Energy Physics::Experiment
Abstract

This letter presents a combined measurement of the energy spectra of atmospheric $��_e$ and $��_��$ in the energy range between $\sim$100 GeV and $\sim$50 TeV with the ANTARES neutrino telescope. The analysis uses 3012 days of detector livetime in the period 2007--2017, and selects 1016 neutrinos interacting in (or close to) the instrumented volume of the detector, yielding shower-like events (mainly from $��_e+\overline ��_e$ charged current plus all neutrino neutral current interactions) and starting track events (mainly from $��_��+ \overline ��_��$ charged current interactions). The contamination by atmospheric muons in the final sample is suppressed at the level of a few per mill by different steps in the selection analysis, including a Boosted Decision Tree classifier. The distribution of reconstructed events is unfolded in terms of electron and muon neutrino fluxes. The derived energy spectra are compared with previous measurements that, above 100 GeV, are limited to experiments in polar ice and, for $��_��$, to Super-Kamiokande., Accepted to PLB

Published
2021
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5. Linking Glass-Transition Behavior to Photophysical and Charge Transport Properties of High-Mobility Conjugated Polymers

Author

Xiao, M, Sadhanala, A, Abdi-Jalebi, M, Thomas, TH, Ren, X, Zhang, T, Chen, H, Carey, RL, Wang, Q, Senanayak, SP, Jellett, C, Onwubiko, A, Moser, M, Liao, H, Yue, W, McCulloch, I, Nikolka, M, Sirringhaus, H, Sirringhaus, H [0000-0001-9827-6061], and Apollo - University of Cambridge Repository

Subjects
donor&#8211, dynamic mechanical analysis, conjugated polymers, glass transition, donor–, acceptor polymers, charge transport
Abstract

The measurement of the mechanical properties of conjugated polymers can reveal highly relevant information linking optoelectronic properties to underlying microstructures and the knowledge of the glass transition temperature ( Tg ) is paramount for informing the choice of processing conditions and for interpreting the thermal stability of devices. In this work, we use dynamical mechanical analysis (DMA) to determine Tg of a range of state-of-the-art conjugated polymers with different degrees of crystallinity that are widely studied for applications in organic field-effect transistors (OFETs). We compare our measured values for Tg to the theoretical value predicted by a recent work based on the concept of effective mobility ζ. The comparison shows that for conjugated polymers with a modest length of the monomer units, the Tg values agree well with theoretical predictions. However, for the near-amorphous, indacenodithiophene–benzothiadiazole (IDT-BT) family of polymers with more extended backbone units, values for Tg appear to be significantly higher predicted by theory. We find instead that values for Tg are correlated with the sub-bandgap optical absorption suggesting the possible role of the interchain short contacts within materials’ amorphous domains.

Published
2021

6. Combined search for neutrinos from dark matter self-annihilation in the Galactic Center with ANTARES and IceCube

Author

Albert, A, André, M, Anghinolfi, M, Ardid, M, Aubert, J-J, Aublin, J, Baret, B, Basa, S, Belhorma, B, Bertin, V, Biagi, S, Bissinger, M, Boumaaza, J, Bouta, M, Bouwhuis, MC, Brânzaş, H, Bruijn, R, Brunner, J, Busto, J, Capone, A, Caramete, L, Carr, J, Celli, S, Chabab, M, Chau, TN, Moursli, R Cherkaoui El, Chiarusi, T, Circella, M, Coleiro, A, Colomer, M, Coniglione, R, Coyle, P, Creusot, A, Díaz, AF, Deschamps, A, Distefano, C, Di Palma, I, Domi, A, Donzaud, C, Dornic, D, Drouhin, D, Eberl, T, Khayati, N El, Enzenhöfer, A, Ettahiri, A, Fermani, P, Ferrara, G, Filippini, F, Fusco, L, Gay, P, Glotin, H, Gozzini, R, Ruiz, R Gracia, Graf, K, Guidi, C, Hallmann, S, van Haren, H, Heijboer, AJ, Hello, Y, Hernández-Rey, JJ, Hößl, J, Hofestädt, J, Huang, F, Illuminati, G, James, CW, de Jong, M, de Jong, P, Jongen, M, Kadler, M, Kalekin, O, Katz, U, Khan-Chowdhury, NR, Kouchner, A, Kreykenbohm, I, Kulikovskiy, V, Lahmann, R, Le Breton, R, Lefèvre, D, Leonora, E, Levi, G, Lincetto, M, Lopez-Coto, D, Loucatos, S, Maggi, G, Manczak, J, Marcelin, M, Margiotta, A, Marinelli, A, Martínez-Mora, JA, Mele, R, Melis, K, Migliozzi, P, Moser, M, Moussa, A, Muller, R, Nauta, L, Navas, S, Nezri, E, Nielsen, C, and Nuñez-Castiñeyra, A

Subjects
astro-ph.HE, Quantum Physics, Particle and Plasma Physics, Astrophysics::High Energy Astrophysical Phenomena, Molecular, Nuclear, Astrophysics::Cosmology and Extragalactic Astrophysics, Atomic, Nuclear & Particles Physics, Astronomical and Space Sciences
Abstract

We present the results of the first combined dark matter search targeting the Galactic Centre using the ANTARES and IceCube neutrino telescopes. For dark matter particles with masses from 50 to 1000 GeV, the sensitivities on the self-annihilation cross section set by ANTARES and IceCube are comparable, making this mass range particularly interesting for a joint analysis. Dark matter self-annihilation through the $\tau^+\tau^-$, $\mu^+\mu^-$, $b\bar{b}$ and $W^+W^-$ channels is considered for both the Navarro-Frenk-White and Burkert halo profiles. In the combination of 2,101.6 days of ANTARES data and 1,007 days of IceCube data, no excess over the expected background is observed. Limits on the thermally-averaged dark matter annihilation cross section $\langle\sigma_A\upsilon\rangle$ are set. These limits present an improvement of up to a factor of two in the studied dark matter mass range with respect to the individual limits published by both collaborations. When considering dark matter particles with a mass of 200 GeV annihilating through the $\tau^+\tau^-$ channel, the value obtained for the limit is $7.44 \times 10^{-24} \text{cm}^{3}\text{s}^{-1}$ for the Navarro-Frenk-White halo profile. For the purpose of this joint analysis, the model parameters and the likelihood are unified, providing a benchmark for forthcoming dark matter searches performed by neutrino telescopes.

Published
2020

7. ANTARES and IceCube Combined Search for Neutrino Point-like and Extended Sources in the Southern Sky

Author

Albert, A, André, M, Anghinolfi, M, Anton, G, Ardid, M, Aubert, JJ, Aublin, J, Baret, B, Basa, S, Belhorma, B, Bertin, V, Biagi, S, Bissinger, M, Boumaaza, J, Bourret, S, Bouta, M, Bouwhuis, MC, Brânzaş, H, Bruijn, R, Brunner, J, Busto, J, Capone, A, Caramete, L, Carr, J, Celli, S, Chabab, M, Chau, TN, El Moursli, RC, Chiarusi, T, Circella, M, Coleiro, A, Colomer, M, Coniglione, R, Costantini, H, Coyle, P, Creusot, A, Diáz, AF, Wasseige, GD, Deschamps, A, Distefano, C, Palma, ID, Domi, A, Donzaud, C, Dornic, D, Drouhin, D, Eberl, T, Bojaddaini, IE, Khayati, NE, Elsässer, D, Enzenhöfer, A, Ettahiri, A, Fassi, F, Fermani, P, Ferrara, G, Filippini, F, Fusco, L, Gay, P, Glotin, H, Gozzini, R, Ruiz, RG, Graf, K, Guidi, C, Hallmann, S, Van Haren, H, Heijboer, AJ, Hello, Y, Hernández-Rey, JJ, Hößl, J, Hofestädt, J, Illuminati, G, James, CW, Jong, MD, Jong, PD, Jongen, M, Kadler, M, Kalekin, O, Katz, U, Khan-Chowdhury, NR, Kouchner, A, Kreter, M, Kreykenbohm, I, Kulikovskiy, V, Lahmann, R, Breton, RL, Lefèvre, D, Leonora, E, Levi, G, Lincetto, M, Lopez-Coto, D, Loucatos, S, Maggi, G, Manczak, J, Marcelin, M, Margiotta, A, Marinelli, A, Martínez-Mora, JA, Mele, R, Melis, K, Migliozzi, P, and Moser, M

Subjects
astro-ph.HE, Particle and Plasma Physics, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, Molecular, Nuclear, Astronomy & Astrophysics, Physical Chemistry, Atomic, Astrophysics::Galaxy Astrophysics, Astronomical and Space Sciences, Physical Chemistry (incl. Structural)
Abstract

A search for point-like and extended sources of cosmic neutrinos using data collected by the ANTARES and IceCube neutrino telescopes is presented. The data set consists of all the track-like and shower-like events pointing in the direction of the Southern Sky included in the nine-year ANTARES point-source analysis, combined with the throughgoing track-like events used in the seven-year IceCube point-source search. The advantageous field of view of ANTARES and the large size of IceCube are exploited to improve the sensitivity in the Southern Sky by a factor of ∼2 compared to both individual analyses. In this work, the Southern Sky is scanned for possible excesses of spatial clustering, and the positions of preselected candidate sources are investigated. In addition, special focus is given to the region around the Galactic Center, whereby a dedicated search at the location of SgrA∗ is performed, and to the location of the supernova remnant RXJ 1713.7-3946. No significant evidence for cosmic neutrino sources is found, and upper limits on the flux from the various searches are presented.

Published
2020

8. The energy calibration system for CANDLES using (n, ��) reaction

Author

Iida, T., Mizukoshi, K., Ohata, T., Uehara, T., Batpurev, T., Chan, W. M., Fushimi, K., Hazama, R., Ishikawa, M., Kakubata, H., Kanagawa, K., Katagiri, S., Khai, B. T., Kishimoto, T., Li, X., Maeda, T., Matsuoka, K., Morishita, K., Moser, M., Nakajima, K., Nomachi, M., Ogawa, I., Shokati, M., Suzuki, K., Takemoto, Y., Takihira, Y., Tamagawa, Y., Tetsuno, K., Trang, V. T. T., Umehara, S., and Yoshida, S.

Subjects
High Energy Physics - Experiment (hep-ex), Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), Nuclear Experiment (nucl-ex)
Abstract

CAlcium fluoride for the study of Neutrinos and Dark matters by Low-energy Spectrometer (CANDLES) searches for neutrino-less double beta decay of $^{48}$Ca using a CaF$_2$ scintillator array. A high Q-value of $^{48}$Ca at 4,272 keV enabled us to achieve very low background condition, however, at the same it causes difficulties in calibrating the detector's Q-value region because of the absence of a standard high-energy $��$-ray source. Therefore, we have developed a novel calibration system based on $��$-ray emission by neutron capture on $^{28}$Si, $^{56}$Fe and $^{58}$Ni nuclei. In the paper, we report the development of the new calibration system as well as the results of energy calibration in CANDLES up to 9 MeV., 6 pages, 7 figures

Published
2020
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9. MOG Antibody Pathogenicity

Author

Spadaro, M., Winklmeier, S., Beltrán, E., Macrini, C., Höftberger, R., Schuh, E., Thaler, F.S., Gerdes, L.A., Laurent, S.A., Gerhards, R., Brändle, S., Dornmair, K., Breithaupt, C., Krumbholz, M., Moser, M., Kirshnamoorthy, G., Kamp, F., Jenne, D., Hohlfeld, R., Kümpfel, T., Lassmann, H., Kawakami, N., and Meinl, E.

Subjects
Adult, Inflammation, Male, Encephalomyelitis, Autoimmune, Experimental, Guinea Pigs, Brain, Middle Aged, nervous system diseases, Rats, Young Adult, nervous system, immune system diseases, Rats, Inbred Lew, Animals, Humans, Female, Myelin-Oligodendrocyte Glycoprotein, Aged, Autoantibodies
Abstract

ObjectiveAutoantibodies against myelin oligodendrocyte glycoprotein (MOG) occur in a proportion of patients with inflammatory demyelinating diseases of the central nervous system (CNS). We analyzed their pathogenic activity by affinity-purifying these antibodies (Abs) from patients and transferring them to experimental animals.MethodsPatients with Abs to MOG were identified by cell-based assay. We determined the cross-reactivity to rodent MOG and the recognized MOG epitopes. We produced the correctly folded extracellular domain of MOG and affinity-purified MOG-specific Abs from the blood of patients. These purified Abs were used to stain CNS tissue and transferred in 2 models of experimental autoimmune encephalomyelitis. Animals were analyzed histopathologically.ResultsWe identified 17 patients with MOG Abs from our outpatient clinic and selected 2 with a cross-reactivity to rodent MOG; both had recurrent optic neuritis. Affinity-purified Abs recognized MOG on transfected cells and stained myelin in tissue sections. The Abs from the 2 patients recognized different epitopes on MOG, the CC and the FG loop. In both patients, these Abs persisted during our observation period of 2 to 3 years. The anti-MOG Abs from both patients were pathogenic upon intrathecal injection in 2 different rat models. Together with cognate MOG-specific T cells, these Abs enhanced T-cell infiltration; together with myelin basic protein-specific T cells, they induced demyelination associated with deposition of C9neo, resembling a multiple sclerosis type II pathology.InterpretationMOG-specific Abs affinity purified from patients with inflammatory demyelinating disease induce pathological changes in vivo upon cotransfer with myelin-reactive T cells, suggesting that these Abs are similarly pathogenic in patients. Ann Neurol 2018;84:315-328

Published
2018

10. Incidence and trends of childhood Type 1 diabetes worldwide 1990–1999

Author

THE DIAMOND PROJECT GROUP, BESSAOUD K, BOUDRAA G, DE ROPOLO MM, DE SEREDAY M, MARTI ML, MOSER M, LAPERTOSA S, DAMIANO M, VERGE C, HOWARD N, SCHOBER E, JORDAN O, WEETS I, GORUS F, COECKELBERGHS M, ROOMAN R, VAN GAAL L, FRANCO LJ, FERREIRA SRG, LISBOA HPK, KURTZ LA, GRAEBIN R, KUTZKE L, RODRIGES C, SAVOVA R, CHRISTOV V, IOTOVA V, TZANEVA V, PACAUD D, TOTH E, TAN MH, CARRASCO E, PEREZ F, ZE Y, BO Y, CHEN S, FU L, DENG L, SHEN S, TENG K, WANG C, JIAN H, JU J, YAN C, DENG Y, LI C, ZHANG Y, LIU Y, LONG X, ZHEN Z, SUN Z, WANG B, WONG G, ORREGO OV, ASCHNER P, DIAZ DIAZ O, DE ACOSTA OM, CINEK O, VAVRINEC J, OLSEN BS, SVENDSEN AJ, KREUTZFELDT J, LUND E, TULL ES, SELMAN GEARA A, ALMONTE AS, PODAR T, TUOMILEHTO J, KARVONEN M, NOTKOLA IL, MOLTCHANOVA E, TASKINEN O, LEVY MARCHAL C, CZERNICHOW P, KOCAVA M, NEU A, EHEHALT S, ROSENBAUER J, GIANI G, ICKS A, BARTSOCAS C, VAZEOU A, SOLTESZ G, LARON Z, GORDON O, ALBAG Y, SHAMIS I, PURRELLO F, ARPI M, FICHERA G, MANCUSO M, LUCENTI C, CHIUMELLO G, BRUNO G, PAGANO G, SONGINI M, CASU A, MARINARO A, FRONGIA P, ZEDDA MA, MILIA A, TENCONI MT, POZZILLI P, VISALLI N, SEBASTIANI L, MARIETTI G, BUZZETTI R, CHERUBINI V, OKUNO A, HARADA S, MATSUURA N, MIKI E, MIYAMOTO S, SASAKI N, MIMURA G, SHALTOUT A, QABAZRD M, AL KHAWARI M, BRIGIS G, DZIVITE I, KADIKI O, URBONAITE B, DE BEAUFORT C, GAREEBOO H, RUEDA OA, REESER M, ELLIOTT R, SCOTT R, WILLIS J, DARLOW B, JONER G, RAFIQUE G, JAWAD F, JIMENEZ J, PALACIOS CM, CANETE F, VERA J, ALMIRON R, BENITEZ GE, ESPINOLA CS, SECLEN S, WOZNICKA D, SZYBINSKI Z, PLACZKIEWICZ E, JAROSZ CHOBOT P, MENEZES C, PINA EA, RUAS MMA, RODRIGUES FJC, ABREU S, IONESCU TIRGOVISTE C, SHUBNIKOV E, MICHALKOVA D, BARK L, HLAVA P, MIKULECKY M, KRZISNIK C, BATTELINO T, URSIC NB, KOTNIK P, KO KW, CASTELL C, GODAY A, MAGZOUB M, DAHLQUIST G, SCHOENLE E, NAGATI K, KHALIFA FB, BURDEN A, RAYMOND N, MILLWARD BA, ZHAO H, PATTERSON CC, CARSON D, HADDEN D, SMAIL P, MCSPORRAN B, WAUGH N, BINGLEY P, MCKINNEY PA, FELTBOWER RG, BODANSKY HJ, CAMPBELL F, LAPORTE RE, LIBMAN I, ROSEMAN J, RAHMAN SMA, DE LLADO TF, LIPTON R, JORGE AM, GUNCZLER P, LANES R., DEVOTI, Gabriele, THE DIAMOND PROJECT, Group, Bessaoud, K, Boudraa, G, DE ROPOLO, Mm, DE SEREDAY, M, Marti, Ml, Moser, M, Lapertosa, S, Damiano, M, Verge, C, Howard, N, Schober, E, Jordan, O, Weets, I, Gorus, F, Coeckelberghs, M, Rooman, R, VAN GAAL, L, Franco, Lj, Ferreira, Srg, Lisboa, Hpk, Kurtz, La, Graebin, R, Kutzke, L, Rodriges, C, Savova, R, Christov, V, Iotova, V, Tzaneva, V, Pacaud, D, Toth, E, Tan, Mh, Carrasco, E, Perez, F, Ze, Y, Bo, Y, Chen, S, Fu, L, Deng, L, Shen, S, Teng, K, Wang, C, Jian, H, Ju, J, Yan, C, Deng, Y, Li, C, Zhang, Y, Liu, Y, Long, X, Zhen, Z, Sun, Z, Wang, B, Wong, G, Orrego, Ov, Aschner, P, DIAZ DIAZ, O, DE ACOSTA, Om, Cinek, O, Vavrinec, J, Olsen, B, Svendsen, Aj, Kreutzfeldt, J, Lund, E, Tull, E, SELMAN GEARA, A, Almonte, A, Podar, T, Tuomilehto, J, Karvonen, M, Notkola, Il, Moltchanova, E, Taskinen, O, LEVY MARCHAL, C, Czernichow, P, Kocava, M, Neu, A, Ehehalt, S, Rosenbauer, J, Giani, G, Icks, A, Bartsocas, C, Vazeou, A, Soltesz, G, Laron, Z, Gordon, O, Albag, Y, Shamis, I, Purrello, F, Arpi, M, Fichera, G, Mancuso, M, Lucenti, C, Chiumello, G, Bruno, G, Pagano, G, Songini, M, Casu, A, Marinaro, A, Frongia, P, Zedda, Ma, Milia, A, Tenconi, Mt, Devoti, Gabriele, Pozzilli, P, Visalli, N, Sebastiani, L, Marietti, G, Buzzetti, R, Cherubini, V, Okuno, A, Harada, S, Matsuura, N, Miki, E, Miyamoto, S, Sasaki, N, Mimura, G, Shaltout, A, Qabazrd, M, AL KHAWARI, M, Brigis, G, Dzivite, I, Kadiki, O, Urbonaite, B, DE BEAUFORT, C, Gareeboo, H, Rueda, Oa, Reeser, M, Elliott, R, Scott, R, Willis, J, Darlow, B, Joner, G, Rafique, G, Jawad, F, Jimenez, J, Palacios, Cm, Canete, F, Vera, J, Almiron, R, Benitez, Ge, Espinola, C, Seclen, S, Woznicka, D, Szybinski, Z, Placzkiewicz, E, JAROSZ CHOBOT, P, Menezes, C, Pina, Ea, Ruas, Mma, Rodrigues, Fjc, Abreu, S, IONESCU TIRGOVISTE, C, Shubnikov, E, Michalkova, D, Bark, L, Hlava, P, Mikulecky, M, Krzisnik, C, Battelino, T, Ursic, Nb, Kotnik, P, Ko, Kw, Castell, C, Goday, A, Magzoub, M, Dahlquist, G, Schoenle, E, Nagati, K, Khalifa, Fb, Burden, A, Raymond, N, Millward, Ba, Zhao, H, Patterson, Cc, Carson, D, Hadden, D, Smail, P, Mcsporran, B, Waugh, N, Bingley, P, Mckinney, Pa, Feltbower, Rg, Bodansky, Hj, Campbell, F, Laporte, Re, Libman, I, Roseman, J, Rahman, Sma, DE LLADO, Tf, Lipton, R, Jorge, Am, Gunczler, P, and Lanes, R.

Subjects
Male, Adolescent, type 1 diabetes, Incidence, Endocrinology, Diabetes and Metabolism, Infant, Newborn, Infant, Global Health, World Health Organization, trend, Diabetes Mellitus, Type 1, Endocrinology, Child, Preschool, geographical distribution, incidence, Internal Medicine, Humans, epidemiology, Female, Child
Abstract

Aims. To examine incidence and trends of Type 1 diabetes worldwide for the period 1990–1999. Methods. The incidence of Type 1 diabetes (per 100000/year) was analysed in children aged ≤ 14 years from 114 populations in 112 centres in 57 countries. Trends in the incidence of Type 1 diabetes were analysed by fitting Poisson regression models to the dataset. Results. A total of 43013 cases were diagnosed in the study populations of 84 million children. The age-adjusted incidence of Type 1 diabetes among 112 centres (114 populations) varied from 0.1 per 100000/year in China and Venezuela to 40.9 per 100000/year in Finland. The average annual increase in incidence calculated from 103 centres was 2.8% (95% CI 2.4–3.2%). During the years 1990–1994, this increase was 2.4% (95% CI 1.3–3.4%) and during the second study period of 1995–1999 it was slightly higher at 3.4% (95% CI 2.7– 4.3%). The trends estimated for continents showed statistically significant increases all over the world (4.0% in Asia, 3.2% in Europe and 5.3% in North America), except in Central America and the West Indies where the trend was a decrease of 3.6%. Only among the European populations did the trend in incidence diminish with age. Conclusions. The rising incidence of Type 1 diabetes globally suggests the need for continuous monitoring of incidence by using standardized methods in order to plan or assess prevention strategies.

Published
2006

11. Antikoagulation bei Vorhofflimmern

Author

Bode C and Moser M

Subjects
medicine.medical_specialty, Rivaroxaban, business.industry, Standard treatment, Atrial fibrillation, Thromboembolism Prophylaxis, Vitamin k, medicine.disease, Dabigatran, Internal medicine, Internal Medicine, medicine, Cardiology, Apixaban, Intensive care medicine, business, medicine.drug
Abstract

According to new criteria based on the CHAD(2)DS(2)-VASc score, the threshold for administering anticoagulation therapy for atrial fibrillation patients is being increasingly lowered. With the development of new anticoagulants, more therapy options are available. Currently, vitamin K antagonists are still the standard treatment. However, this therapy is problematic for some patients. Because of the increased bleeding risk and need for continuous blood tests to monitor coagulation, many patients needing anticoagulation therapy are not treated. The new anticoagulants apixaban, rivaroxaban and dabigatran were developed with the goal of avoiding these problems. Dabigatran has already been approved for thromboembolism prophylaxis for patients with atrial fibrillation. All three substances do not require routine control blood tests. Whether the costs saved by this together with the prevention of ischemic and bleeding events justify the higher price of these drugs compared to vitamin K antagonists needs to be examined by socioeconomic studies.

Published
2011

12. Ultrafast ytterbium-doped bulk lasers and laser amplifiers

Author

Hönninger, C., Paschotta, R., Graf, M., Morier-Genoud, F., Zhang, G., Moser, M., Biswal, S., Nees, J., Mourou, G.A., Johannsen, I., Giesen, Adolf, Seeber, W., Keller, U., IQE, ETH Zürich, and IFSW, Uni Stuttgart

Subjects
Physics and Astronomy (miscellaneous), General Engineering, General Physics and Astronomy
Published
1999

13. Retrovirally Transduced Bone Marrow-Derived Dendritic Cells Require CD4+ T Cell Help to Elicit Protective and Therapeutic Antitumor Immunity

Author

De Veerman, Marijke, Heirman, Carlo, Van Meirvenne, Sonja, Devos, Sophie, Corthals, Jurgen, Moser, M., Thielemans, Kris, Physiology, Laboratory of Molecullar and Cellular Therapy, and Vrije Universiteit Brussel

Subjects
CD4-Positive T-Lymphocytes, Antigen Presentation, Mice, Inbred BALB C, Ovalbumin, Genetic Vectors, Histocompatibility Antigens Class I, Immunology, Histocompatibility Antigens Class II, Epitopes, T-Lymphocyte, Bone Marrow Cells, Cell Separation, Dendritic Cells, Lymphocyte Activation, Immunotherapy, Adoptive, Mice, Inbred C57BL, Mice, Animals, Immunology and Allergy, Female, Lymphocyte Culture Test, Mixed, Moloney murine leukemia virus, Peptides, Cells, Cultured, Bone Marrow Transplantation, T-Lymphocytes, Cytotoxic
Abstract

It has been extensively documented that murine dendritic cells loaded with tumor-associated Ag (TAA)-derived peptides or protein can prime Ag-specific CD8+ cytotoxic T cells in vivo and can elicit Ag-specific immunity. Optimal presentation of TAA might be achieved by retroviral transduction of DCs allowing long term and stable expression of the TAA-peptides as well as the presentation of multiple epitopes in the context of MHC class I and/or class II molecules. Here we show that retroviral transduction of bone marrow-derived dendritic cells (DCs) with chicken OVA cDNA or the reporter gene green fluorescent protein retained their potent stimulatory capacity and that the transduced DCs could process and present the endogenously expressed OVA protein. The DCs transduced with cDNA encoding native OVA protein presented OVA-derived peptides in the context of MHC class I as well as MHC class II and induced a strong Ag-specific CTL response. DCs expressing a cytosolic form of OVA presented OVA peptides only in the context of MHC class I and failed to induce an OVA-specific CTL response in vivo when they had been cultured in the absence of exogenous protein. Immunization with retrovirally transduced DCs resulted in an Ag-specific immunity and rejection of a tumor cell challenge and a significant survival advantage in tumor-bearing mice. These results obtained in this rapidly lethal tumor model suggest that DCs transduced with TAA may be useful for tumor immunotherapy and underscore the importance of the simultaneous delivery of T cell help in the development of Ag-specific cytotoxic T-cells.

Published
1999

16. Cardiotoxicity and diuretics: much speculation ??? little substance

Author

McInnes Gt, Ramsay Le, Yeo Ww, and Moser M

Subjects
medicine.medical_specialty, Physiology, Sodium Chloride Symporter Inhibitors, medicine.medical_treatment, Myocardial Infarction, Hyperlipidemias, Benzothiadiazines, Metabolic Diseases, Risk Factors, Internal medicine, Internal Medicine, medicine, Humans, Diuretics, Potassium Deficiency, Thiazide, Clinical Trials as Topic, Chemotherapy, Cardiotoxicity, business.industry, Metabolic disorder, Arrhythmias, Cardiac, medicine.disease, Coronary heart disease, Endocrinology, Hypertension, Toxicity, Cardiology, Diuretic, Cardiology and Cardiovascular Medicine, business, Magnesium Deficiency, medicine.drug
Published
1992

19. Treatment of mice bearing BCL1 lymphoma with bispecific antibodies

Author

Brissinck, Jan, Demanet, Christian, Moser, M., Leo, O., Thielemans, Kris, Physiology, Laboratory of Molecullar and Cellular Therapy, Hematology, and Pathology/molecular and cellular medicine

Subjects
Cytotoxicity, Immunologic, Lymphoma, B-Cell, mice, Antibodies, Neoplasm, T-Lymphocytes, Immunology, Antibody-Dependent Cell Cytotoxicity, Mice, Inbred Strains, Flow Cytometry, Lymphocyte Activation, Survival Analysis, Antibodies, Anti-Idiotypic, Animals, Immunology and Allergy, immunotherapy
Abstract

Bispecific antibodies with specificity for the CD3/TCR complex of CTL and a target cell Ag can bridge both cell types and trigger cellular cytoxicity. We have produced bispecific antibodies, directed against the surface-expressed Id of the mouse BCL1 lymphoma and the mouse CD3 complex, by hybrid-hybridoma fusion. Two recombination Ig were purified to homogeneity: B1 X 7D6F, which is univalent for Id and CD3 binding and B1 X 7D6M, which is univalent for Id binding but has lost the CD3 binding because of association of the anti-CD3 H chain with the inappropriate L chain. In vitro studies indicate that bridging the TCR/CD3 complex of resting T cells with tumor IgM Id and the appropriate bispecific antibody induced proliferation and secretion of IL-2. Furthermore, in cytotoxicity assays using 51Cr-labeled tumor cells, preactivated T cells could be targeted with the bispecific antibody to give complete lysis of the Ag+ tumor. Finally, the activity of the bispecific antibody was confirmed in vivo. Animals treated i.v. with 5 micrograms of bispecific antibody 9 days after receiving BCL1 cells were cured. Furthermore, when these animals were checked at 150 days for dormant or variant tumors, as have been reported after other forms of immunotherapy in this model, none could be found. Immunotherapy experiments comparing a mixture of control antibodies with the bispecific antibody demonstrate that tumor cell-T cell bridging is established in vivo and is required for therapeutic success. These results indicate the importance of bispecific antibodies as a novel form of treatment for cancer.

Published
1991

20. The growth of multispecialty medical groups 1982–1989

Author

Moser M

Subjects
Attitude of Health Personnel, business.industry, Health Policy, Health Maintenance Organizations, California, Economics, Medical, Group Practice, Prepaid, Physicians, Income, Medicine, Capitation Fee, business, Specialization
Published
1991

21. Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction

Author

Ussar, S., Moser, M., Widmaier, M., Rognoni, E., Harrer, C., Genzel-Boroviczeny, O., and Fässler, R.

Subjects
lcsh:QH426-470, Dermatology/Pediatric Skin Diseases, including Genetic Diseases, Biochemistry, Epithelium, Cell Line, Gene Knockout Techniques, Mice, Dermatology/Photodermatology and Skin Aging, Cell Adhesion, Animals, Humans, Intestinal Mucosa, Genetics and Genomics/Genetics of Disease, Skin, Mice, Knockout, Gastroenterology and Hepatology/Inflammatory Bowel Disease, integumentary system, Skin Diseases, Genetic, Intestines, lcsh:Genetics, Cell Biology/Cell Adhesion, Animals, Newborn, Genetics and Genomics/Disease Models, Immunology/Immune Response, Colitis, Ulcerative, Atrophy, Carrier Proteins, Research Article
Abstract

Kindler Syndrome (KS), characterized by transient skin blistering followed by abnormal pigmentation, skin atrophy, and skin cancer, is caused by mutations in the FERMT1 gene. Although a few KS patients have been reported to also develop ulcerative colitis (UC), a causal link to the FERMT1 gene mutation is unknown. The FERMT1 gene product belongs to a family of focal adhesion proteins (Kindlin-1, -2, -3) that bind several β integrin cytoplasmic domains. Here, we show that deleting Kindlin-1 in mice gives rise to skin atrophy and an intestinal epithelial dysfunction with similarities to human UC. This intestinal dysfunction results in perinatal lethality and is triggered by defective intestinal epithelial cell integrin activation, leading to detachment of this barrier followed by a destructive inflammatory response., Author Summary Mutations in FERMT1, coding for the Kindlin-1 protein, cause Kindler Syndrome in humans, characterized by skin blistering, atrophy, and cancer. Recent reports showed that some Kindler Syndrome patients additionally suffer from ulcerative colitis. However, it is unknown whether this is caused by loss of Kindlin-1 or by unrelated abnormalities such as infections or additional mutations. We ablated the Fermt1 gene in mice to directly analyze the pathological consequences and the molecular mode of action of Kindlin-1. Kindlin-1–deficient mice develop a severe epidermal atrophy, but lack blisters. All mutant mice die shortly after birth from a dramatic, shear force-induced detachment of intestinal epithelial cells followed by a profound inflammation and organ destruction. The intestinal phenotype is very similar to, although more severe than, the one observed in Kindler Syndrome patients. In vitro studies revealed that impaired integrin activation, and thus impaired adhesion, to the extracellular matrix of the intestinal wall causes intestinal epithelial cell detachment. Therefore, we demonstrate that intestinal epithelial cells require adhesive function of integrins to resist the shear force applied by the stool. Furthermore, we provide evidence that the colitis associated with Kindler Syndrome is caused by a dysfunction of Kindlin-1 rather than by a Kindlin-1–independent event.

Published
2008

25. Anti-CD3 antibodies induce T cells from unprimed animals to secrete IL-4 both in vitro and in vivo

Author

Véronique Flamand, Abramowicz, D., Goldman, M., Biernaux, C., Huez, G., Urbain, J., Moser, M., and Leo, O.

Subjects
Immunology, Immunology and Allergy
Abstract

Recently, functional heterogeneity among Th cells has been recognized. Based on pattern of lymphokine secretion, two mutually exclusive subsets of CD4+ cells have been defined and designated Th1 (secreting IL-2 and IFN-gamma) and Th2 (secreting IL-4 and IL-5). Identification of these subsets was mostly based on the study of long term cultured T cell lines and clones, and little is known about the Th heterogeneity in vivo. In particular, it has been suggested that IL-4 producing cells cannot be detected in vivo or in primary stimulations in vitro unless responder cells had been previously primed. Our data however, indicate that anti-CD3 mediated stimulation can induce T cells isolated from unprimed animals to IL-4 production. An assay system based on the ability of IL-4 to increase Ia expression of B cells present in the environment of activated T cells was found to be more sensitive than detection of secreted IL-4 in the supernatant by conventional bioassays and was used to study IL-4 production by unprimed lymphocytes polyclonally stimulated in vivo and in vitro by anti-CD3 mAb. The results obtained indicate that CD4+ CD8- T cells able to produce IL-4 upon receptor-specific stimulation exist in the preimmune pool of adult animals. Remarkably, these cells can also be stimulated in vivo by treating animals with anti-CD3 mAb, as indicated by the in vivo induction of IL-4 specific mRNA and hyper-Ia expression on B cells. These results indicate that the inability to detect IL-4 in primary cultures is not due to different activation requirements of Th2 cells but may simply result from their lower frequency in unprimed animals.

Published
1990

26. DIS-ALP Disaster Information System of alpine Regions

Author

Berger E., Grisotto S., Hübl J., Kienholz H., Kollariots S., Leber D., Loipersberger A., Marchi L., Mazzorana B., Moser M., Nössing T., Riedler W., Scheidl C., Schmid F., Schnetzer I., Siegel H., and Volk G.

Subjects
landslide, field surveys, debris flow, documentation
Published
2007

27. Spiral phases and two-particle bound states from a systematic low-energy effective theory for magnons, electrons, and holes in an antiferromagnet

Author

Brügger, C., Hofmann, C. P., Kämpfer, F., Moser, M., Pepe, M., and Wiese, U. -J.

Subjects
Physics, Condensed matter physics, Strongly Correlated Electrons (cond-mat.str-el), Magnon, FOS: Physical sciences, Position and momentum space, Electron, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, Schrödinger equation, symbols.namesake, Condensed Matter - Strongly Correlated Electrons, Bound state, symbols, Quasiparticle, Effective field theory, Condensed Matter::Strongly Correlated Electrons, Electrical and Electronic Engineering, Wave function
Abstract

We have constructed a systematic low-energy effective theory for hole- and electron-doped antiferromagnets, where holes reside in momentum space pockets centered at $(\pm\frac{\pi}{2a},\pm\frac{\pi}{2a})$ and where electrons live in pockets centered at $(\frac{\pi}{a},0)$ or $(0,\frac{\pi}{a})$. The effective theory is used to investigate the magnon-mediated binding between two holes or two electrons in an otherwise undoped system. We derive the one-magnon exchange potential from the effective theory and then solve the corresponding two-quasiparticle Schr\"odinger equation. As a result, we find bound state wave functions that resemble $d_{x^2-y^2}$-like or $d_{xy}$-like symmetry. We also study possible ground states of lightly doped antiferromagnets., Comment: 2 Pages; Proc. of SCES'07, Houston

Published
2007
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29. Faulty EPCs in the SAP Reference Model

Author

Mendling, J., Moser, M., Neumann, G., Verbeek, H.M.W., Dongen, van, B.F., Aalst, van der, W.M.P., Dustdar, S., Fiadeiro, J.L., Sheth, A., and Information Systems IE&IS

Subjects
Process modeling, Computer science, Process (engineering), business.industry, Data mining, Artificial intelligence, Petri net, computer.software_genre, business, Reference model, computer
Abstract

Little is known about error probability in enterprise models as they are usually kept private. The SAP reference model is a publically available model that contains more than 600 non-trivial process models expressed in terms of Event-driven Process Chains (EPCs). We have automatically translated these EPCs into YAWL models and analyzed these models using WofYAWL, a verification tool based on Petri nets, in order to acquire knowledge about errors in large enterprise models. We discovered that at least 34 of these EPCs contain errors (i.e., at least 5.6% is flawed) and analyzed which parts of the SAP reference model contain most errors. This systematic analysis of the SAP reference model illustrates the need for verification tools such as WofYAWL.

Published
2006

35. Triple-Therapie bei Stent und Vorhofflimmern - contra

Author

Moser M and Bode C

Subjects
medicine.medical_specialty, Text mining, business.industry, Internal medicine, medicine.medical_treatment, Cardiology, Medicine, Stent, Atrial fibrillation, General Medicine, business, medicine.disease
Published
2013

36. The national dose registry for radiation workers in Switzerland

Author

Moser M

Subjects
Male, medicine.medical_specialty, Databases, Factual, Epidemiology, Special solution, Health, Toxicology and Mutagenesis, Guidelines as Topic, Radiation Dosage, Government Agencies, Radiation Protection, Pregnancy, Radiation Monitoring, medicine, Dosimetry, Humans, Radiology, Nuclear Medicine and imaging, Medical physics, Registries, Occupational Health, business.industry, Public health, Regulatory control, Database structure, Internal dose, Total dose, Female, Radiation protection, business, Health Physics, Switzerland
Abstract

The national dose registry began operation in Swit-zerland in 1990. It is a database maintained by the Federal Office of Public Health. It contains personal, employment, and dosimetric data for all the radiation workers in the country. The data for about 60,000 currently employed radiation workers are transferred from ten external dosimetry services to the registry every month or every three months. The registry was initiated to assist national authorities in controlling and safekeeping of the occupational doses and to allow statistical evaluations. In autumn 1994 the new Radiation Protection Regulations came into effect. Based on the ICRP recommendations, the Regulations introduced lower limits for the annual dose, for the average dose over five years, and for pregnant women and defined the internal dose as an additive component to the total dose. All these items require a high quality registration of occupational doses. This can hardly be achieved without a central registry. This paper describes the design of the Swiss national dose registry in the frame of the particular organization of the personal dosimetry in this country. The database structure and the information content are presented. Special solutions for the data transfer have been found, as the registry is running completely decoupled from the dosimetry services. Applications of the registry for regulatory control, particularly in connection with the new Regulations are described. Some results of statistical analyses are presented. The possibilities and the limitations of using the registry for radioepidemiological studies are discussed.

Published
1995

37. Do different hemodynamic effects of antihypertensive drugs translate into different safety profiles?

Author

Moser M

Subjects
Pharmacology, business.industry, medicine.medical_treatment, Vasodilator Agents, Hemodynamics, Vasodilation, General Medicine, Exercise intolerance, Renal artery stenosis, medicine.disease, Blood pressure, Anesthesia, medicine, Sympatholytics, Animals, Humans, Pharmacology (medical), Diuretic, medicine.symptom, Adverse effect, Hyponatremia, business, Diuretics, Antihypertensive Agents
Abstract

Various antihypertensive drugs reduce blood pressure by different mechanisms. In some instances, adverse reactions occur because of specific hemodynamic effects. Examples include syncope with alpha-blockade or vasodilator therapy; fatigue or exercise intolerance with the reduction in cardiac output following the use of beta-adrenergic inhibitors; edema, headaches, or dizziness with the use of vasodilators such as calcium entry blockers; renal failure in patients with renal artery stenosis or renal insufficiency following the use of ACE inhibitors; and marked hyponatremia with volume depletion following the use of diuretics, especially in elderly patients. In the majority of patients, however, blood pressure lowering can be achieved without significant adverse effects. Combining small doses of different agents with different hemodynamic actions often results in good blood pressure control and minimal reactions. Examples of these include diuretics and beta-adrenergic inhibitors, diuretics and ACE inhibitors, and beta-blockers and vasodilators.

Published
1990

38. Experimentelle Vestibulometrie

Author

Moser M

Subjects
Vestibular system, Angular acceleration, Nuclear magnetic resonance, Amplitude, Otorhinolaryngology, business.industry, Medicine, General Medicine, Habituation, Slow component, business, Degree (music)
Abstract

25 rabbits are investigated by the pendular test. By an angular acceleration of 90 degrees/s2 the averaged values of the nystagmic parameters are: the amplitude 12 mm, the frequency 8 beats in a half periode, the angle velocity of the slow component 50--60 mm/s and the threshold for the pendular test 2--5 degrees/s2 and the rotationstest 1 degree/s2. There is no vestibular habituation and no fatigue. Always the nystagmic reaction is clear and reproducible.

Published
1978

39. Search for neutrinos from the tidal disruption events AT2019dsg and AT2019fdr with the ANTARES telescope

Author

ANTARES Collaboration, Albert, A., Alves, S., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J. -J., Aublin, J., Baret, B., Basa, S., Belhorma, B., Bendahman, M., Benfenati, F., Bertin, V., Biagi, S., Bissinger, M., Boumaaza, J., Bouta, M., Bouwhuis, M. C., Brânzaş, H., Bruijn, R., Brunner, J., Busto, J., Caiffi, B., Capone, A., Caramete, L., Carr, J., Carretero, V., Celli, S., Chabab, M., Chau, T. N., Moursli, R. Cherkaoui El, Chiarusi, T., Circella, M., Coleiro, A., Colomer-Molla, M., Coniglione, R., Coyle, P., Creusot, A., Díaz, A. F., de Wasseige, G., Deschamps, A., Distefano, C., Di Palma, I., Domi, A., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., van Eeden, T., Khayati, N. El, Enzenhöfer, A., Fermani, P., Ferrara, G., Filippini, F., Fusco, L., García, R., Gatelet, Y., Gay, P., Glotin, H., Gozzini, R., Graf, K., Guidi, C., Hallmann, S., van Haren, H., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Hößl, J., Hofestädt, J., Huang, F., Illuminati, G., James, C. W., Jisse-Jung, B., de Jong, M., de Jong, P., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Breton, R. Le, Lefèvre, D., Leonora, E., Levi, G., Lincetto, M., Lopez-Coto, D., Loucatos, S., Maderer, L., Manczak, J., Marcelin, M., Margiotta, A., Marinelli, A., Martínez-Mora, J. A., Melis, K., Migliozzi, P., Moser, M., Moussa, A., Muller, R., Nauta, L., Navas, S., Nezri, E., Fearraigh, B. Ó, Organokov, M., Păvălaş, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Pieterse, C., Poirè, C., Popa, V., Pradier, T., Randazzo, N., Reck, S., Riccobene, G., Romanov, A., Greus, F. Salesa, Samtleben, D. F. E., Sánchez-Losa, A., Sanguineti, M., Sapienza, P., Schnabel, J., Schumann, J., Schüssler, F., Spurio, M., Stolarczyk, Th., Taiuti, M., Tayalati, Y., Tingay, S. J., Vallage, B., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., Wilms, J., Zavatarelli, S., Zegarelli, A., Zornoza, J. D., Zúñiga, J., Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Laboratoire d'Informatique et Systèmes (LIS), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Institut méditerranéen d'océanologie (MIO), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), ANTARES, ANR-18-IDEX-0001,Université de Paris,Université de Paris(2018), KM3NeT (IHEF, IoP, FNWI), Astroparticle Physics (IHEF, IoP, FNWI), ATLAS (IHEF, IoP, FNWI), IHEF (IoP, FNWI), Albert, A., Alves, S., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J.-J., Aublin, J., Baret, B., Basa, S., Belhorma, B., Bendahman, M., Benfenati, F., Bertin, V., Biagi, S., Bissinger, M., Boumaaza, J., Bouta, M., Bouwhuis, M. C., Brânzaş, H., Bruijn, R., Brunner, J., Busto, J., Caiffi, B., Capone, A., Caramete, L., Carr, J., Carretero, V., Celli, S., Chabab, M., Chau, T. N., El Moursli, R. Cherkaoui, Chiarusi, T., Circella, M., Coleiro, A., Colomer-Molla, M., Coniglione, R., Coyle, P., Creusot, A., Díaz, A. F., Wasseige, G. de, Deschamps, A., Distefano, C., Palma, I. Di, Domi, A., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., Eeden, T. van, Khayati, N. El, Enzenhöfer, A., Fermani, P., Ferrara, G., Filippini, F., Fusco, L., García, R., Gatelet, Y., Gay, P., Glotin, H., Gozzini, R., Graf, K., Guidi, C., Hallmann, S., Haren, H. van, Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Hößl, J., Hofestädt, J., Huang, F., Illuminati, G., James, C. W., Jisse-Jung, B., Jong, M. de, Jong, P. de, Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Le Breton, R., Lefèvre, D., Leonora, E., Levi, G., Lincetto, M., Lopez-Coto, D., Loucatos, S., Maderer, L., Manczak, J., Marcelin, M., Margiotta, A., Marinelli, A., Martínez-Mora, J. A., Melis, K., Migliozzi, P., Moser, M., Moussa, A., Muller, R., Nauta, L., Navas, S., Nezri, E., Fearraigh, B. Ó, Organokov, M., Păvălaş, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Pieterse, C., Poirè, C., Popa, V., Pradier, T., Randazzo, N., Reck, S., Riccobene, G., Romanov, A., Greus, F. Salesa, Samtleben, D. F. E., Sánchez-Losa, A., Sanguineti, M., Sapienza, P., Schnabel, J., Schumann, J., Schüssler, F., Spurio, M., Stolarczyk, Th., Taiuti, M., Tayalati, Y., Tingay, S. J., Vallage, B., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., Wilms, J., Zavatarelli, S., Zegarelli, A., Zornoza, J. D., Zúñiga, J., Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Andre, M., Aubert, J. -J., Brnzas, H., El Moursli, R. C., Diaz, A. F., Wasseige, G. D., Palma, I. D., Eeden, T. V., Khayati, N. E., Enzenhofer, A., Garcia, R., Haren, H. V., Hernandez-Rey, J. J., Hossl, J., Hofestdt, J., Jong, M. D., Jong, P. D., Lefevre, D., Martinez-Mora, J. A., Fearraigh, B., Pavalas, G. E., Poir, C., Greus, F. S., Sanchez-Losa, A., Schussler, F., Stolarczyk, T., Zuniga, J., Centre Tecnològic de Vilanova i la Geltrú, and Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques

Subjects
Astrofísica, Flux, FOS: Physical sciences, Neutrino telescope, 030226 pharmacology & pharmacy, 01 natural sciences, neutrino: flux, law.invention, IceCube, blazar, Tidal disruption event, Telescope, 03 medical and health sciences, neutrino, 0302 clinical medicine, muon: tracks, law, 0103 physical sciences, Neutrins, Neutrinos, Blazar, 010303 astronomy & astrophysics, detectors, High probability, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Muon, ANTARES, neutrino, astrophysical neutrinos, detectors, Astronomy, Astronomy and Astrophysics, astrophysical neutrinos, Neutrino astrophysics, 13. Climate action, Space and Planetary Science, Neutrino astronomy, FISICA APLICADA, neutrino: flavor, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Telescopes
Abstract

[EN] On 2019 October 1, the IceCube Collaboration detected a muon track neutrino with a high probability of being of astrophysical origin, IC191001A. After a few hours, the tidal disruption event (TDE) AT2019dsg, observed by the Zwicky Transient Facility (ZTF), was indicated as the most likely counterpart of the IceCube track. More recently, the follow-up campaign of the IceCube alerts by ZTF suggested a second TDE, AT2019fdr, as a promising counterpart of another IceCube muon track candidate, IC200530A, detected on 2020 May 30. Here, these intriguing associations are followed-up by searching for neutrinos in the ANTARES detector from the directions of AT2019dsg and AT2019fdr using a time-integrated approach. As no significant evidence for space clustering is found in the ANTARES data, upper limits on the one-flavor neutrino flux and fluence are set., The authors acknowledge the financial support of the funding agencies: Centre National de la Recherche Scientifique (CNRS), Commissariat a l'energie atomique et aux energies alternatives (CEA), Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), LabEx UnivEarthS (ANR-10-LABX-0023 and ANR-18-IDEX-0001), Region Ile-de-France (DIM-ACAV), Region Alsace (contrat CPER), Region Provence-Alpes-Cote d'Azur, Departement du Var and Ville de La Seyne-sur-Mer, France; Bundesministerium fur Bildung und Forschung (BMBF), Germany; Istituto Nazionale di Fisica Nucleare (INFN), Italy; Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; Council of the President of the Russian Federation for young scientists and leading scientific schools supporting grants, Russia; Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI), Romania; Ministerio de Ciencia e Innovacion (MCI) and Agencia Estatal de Investigacion: Programa Estatal de Generacion de Conocimiento (refs. PGC2018-096663-B-C41, -A-C42, -B-C43, -B-C44) (MCI/FEDER), Severo Ochoa Centre of Excellence and MultiDark Consolider, Junta de Andalucia (ref. SOMM17/6104/UGR and A-FQM-053-UGR18), Generalitat Valenciana: Grisolia (ref. GRISOLIA/2018/119) and GenT (ref. CIDEGENT/2018/034) programs, Spain; Ministry of Higher Education, Scientific Research and Professional Training, Morocco. We also acknowledge the technical support of Ifremer, AIM and Foselev Marine for the sea operation and the CC-IN2P3 for the computing facilities.

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