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2. TOMOGRAPHIC PATTERNS IN THE DIAGNOSTIC APPROACH TO COVID 19

Author

María Belén Alvarado Mora, Darwin Daniel Campos González, Luis Alonso Arciniega Jácome, María Fernanda Alvarado Mora, Melanie Doménica Jordán Torres, Rossi Dayana Ramírez Apolo, Karla Vanessa Soto Paucar, Rene Adolfo Salinas Paucar, Karen Elizabeth Guamán Medina, Kenia Noemí Loayza Peñaranda, Gloria Anabel Ortíz Cruz, and Stefi Milena Soto Rodríguez

Published
2023
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3. Nocardiosis pulmonar y del sistema nervioso central: el alcoholismo como factor de inmunocompromiso

Author

Adriana Isabel Márquez, Eduardo Mora, Andrés Felipe Bernal, Andrés Felipe Salazar, Diana Patricia Mora, and Ledmar Jovanny Vargas

Subjects
General Biochemistry, Genetics and Molecular Biology
Abstract

La nocardiosis es una enfermedad de distribución mundial; de forma habitual se encuentra en zonas tropicales y afecta principalmente a pacientes inmunocomprometidos, sin embargo, también existen casos reportados de infección en personas inmunocompetentes. Esta infección es causada por actinomicetos del género Nocardia spp. que son bacterias Gram positivas, saprófitos ambientales. Aunque la exposición a Nocardia spp. es casi universal, solo una pequeña fracción de las personas expuestas desarrollan la enfermedad.Se presenta el caso de un hombre de 47 años, sin dato de inmunosupresión, procedente de un área rural de Boyacá, que consultó por un cuadro clínico de cefalea intensa e intermitente, con parestesias y, finalmente, alteración del estado de conciencia. Se practicó una resonancia magnética cerebral, en la que se evidenció una lesión que ocupaba espacio de localización córtico-subcortical en la región fronto-témporo-parietal izquierda, con efecto compresivo y desplazamiento de las cavidades del sistema ventricular. Se sospechó, inicialmente, una lesión neoplásica o un absceso cerebral. El paciente fue sometido a una resección quirúrgica, y el cultivo de la lesión documentó Nocardia africana/nova; en estudios posteriores, se evidenció un posible foco pulmonar primario. Como único factor de riesgo en el paciente, se documentó alcoholismo. Completó seis semanas de tratamiento antibiótico intrahospitalario con evolución clínica y radiológica, y egresó con plan de un año de terapia antibiótica ambulatoria. Aunque la enfermedad por Nocardia spp. afecta principalmente a pacientes inmunocomprometidos, la “evidencia” clínica demuestra que este microorganismo también puede ser una amenaza para individuos sin los factores de riesgo tradicionales para inmunosupresión.

Published
2023
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4. Grado de conocimiento de las familias del cantón Chimbo, sobre la tenencia responsable de mascotas

Author

Edison Raúl Mora García, Edy Paul Castillo Hidalgo, Karina Gabriela Calapaqui Gaibor, and Kleber Estuardo Espinoza Mora

Abstract

En nuestro entorno los estudios del grado de conocimiento de las familias del cantón Chimbo, sobre la tenencia responsable de las mascotas es nulo, por lo que vimos propicio evaluar de cierta manera esta problemática que está latente y en aumento alrededor del mundo. Objetivo: El objetivo de este trabajo investigativo fue analizar el Grado de conocimiento de las familias del cantón Chimbo, sobre la tenencia responsable de mascotas en sus hogares, investigación realizada en los meses de julio-septiembre de 2022. Metodología: Se utilizó una estadística no experimental, donde se obtuvo información a través de un cuestionario de preguntas donde pudimos conocer cuál es la calidad de vida de los caninos con hogar, su hábitat y cuidados. En esta investigación utilizamos la entrevista (cuestionario y encuesta) en formato digital como método para poder recolectar la información y los datos necesarios. Resultados: Los resultados que se obtuvieron en esta investigación determinan que la mayoría de los encuestados tiene un alto grado de conocimiento sobre la tenencia responsable de mascotas. Conclusiones: Pudimos apreciar que hay un alto grado de responsabilidad de la mayoría de los tutores encuestados en los diversos ámbitos para que una mascota pueda gozar de una vida plena. Área de la ciencia: Medicina veterinaria

Published
2023
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5. TPMT gene polymorphisms (c.238G>C, c.460G>A and c.719A>G) in a healthy Venezuelan population

Author

Yuselin Mora, Cecilia Villegas, Yamile M Mora, and Nancy Moreno

Subjects
Pharmacology, Genetics, Molecular Medicine
Abstract

Background: The presence of polymorphisms in the TPMT gene is associated with adverse effects in patients treated with standard doses of thiopurine drugs. Scientific evidence recognizes significant ethnic differences in their frequencies and how their early identification can prevent clinical complications. Methods: 150 healthy residents of Aragua, Venezuela were enrolled. The SNPs c.460G>A and c.719A>G were detected by PCR–restriction fragment length polymorphism assay and c.238G>C by allele-specific PCR. Results: All genotype polymorphisms were heterozygous. TPMT*1/*3A, TPMT*1/*3C and TPMT*1/*2 genotypes were found in 4.0, 2.0 and 0.7%, respectively. Conclusion: 6.7% of individuals have an intermediate TPMT activity. These findings support the importance of prior genotyping of TPMT in Venezuelan patients who require thiopurine drug therapy.

Published
2023
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6. Association of Time of Day With Outcomes Among Patients Triaged for a Suspected Severe Stroke in Nonurban Catalonia

Author

Álvaro García-Tornel, Alan Flores, Mikel Terceño, Pedro Cardona, Sergi Amaro, Meritxell Gomis, Josep Zaragoza, Jerzy Krupinski, Manuel Gómez-Choco, Natalia Mas, Dolores Cocho, Esther Catena, Francesc Purroy, Matias Deck, Marta Rubiera, Jorge Pagola, David Rodriguez-Luna, Jesús Juega, Noelia Rodríguez-Villatoro, Carlos A. Molina, Cristina Soro, Xavier Jimenez, Mercè Salvat-Plana, Antoni Dávalos, Tudor G Jovin, Sonia Abilleira, Natalia Pérez de la Ossa, Marc Ribó, Estela Sanjuan, Katherine Santana, Olga Maisterra, Estevo Santamarina, Marian Muchada, Sandra Boned, Antonio Palasi Franco, Marta Olivé Gadea, Matías Deck, Manuel Requena, Victoria Sala, Lucía Muñoz, Mónica Millán, Elena López-Cancio, Laura Dorado, María Hernández-Pérez, Jordi Ciurans, Daniela Samaniego, Tamara Canento, Lorena Martin, Anna Planas, Joaquin Broto, Agustín Sorrentino, Martí Paré, Nuole Zhu, Alicia Garrido, Laia Grau, Ane Miren Crespo, Silvia Presas, Miriam Almendrote, Alba Ramos, Giuseppe Lucente, Lourdes Ispierto, Manuel Lozano, Juan Luis Becerra, Marta Jiménez, Dolores Vilas Rolán, Nicolas Guanyabens, Josep Sanchez-Ojanguren, Alicia Martínez-Piñeiro, Sara Forcén, Mireia Gea, Marta Álvarez, Anna Ramos, Manuel Domínguez Lizarbe, Rubio Guerra, Irene Bragado, Andrea Arbex, Luis Rodríguez, Alejandro Bustamante, Pere Cardona Portela, Helena Quesada García, Blanca Lara Rodríguez, Nuria Cayuela, Julia Miró, Clara Marzal, Andrés Paipa, Sergio Campoy, Ana Núñez, Pablo Arroyo, Sarah Besora, Vanessa Adell, Jaume Campdelacreu, Montse Alemany Martí, Belén González, Laura Bau Vila, Marta Fiter Crespo, Anna Berbel, Ma. Cristina Villaescusa Urbaneja, Núria Guillen, Nuria Vidal, Patricia Valentina Vérez Santamaria, Diego Herrero Navarro, Marta Simó, Mercedes Falip, Elisabeth Matas, Neus Mongay Ochoa, Ariadna Gifreu, Albert Muñoz, Lucía Romero, Eduard Portell, Guillermo Hernández Perez, F. Ruiz Esteve, Silvia Teixidor, Augusto Salazar Talavera, Roser Gómez, Xabier Urra Nuin, Martha Vargas, Ángel Chamorro, Laura Llull, Arturo Renú, Salvatore Rudilosso, Raquel Sánchez del Valle, Helena Ariño, Nuria Solà, Delón la Puma, Francisco Gil, Juan Bernardo Gómez, Nuria Matos, Neus Falgàs, Sergi Borrego, Almudena Sánchez, Mircea Balasa, Carmen Montejo, Mar Guasp, David Reyes, Pablo Sánchez Cervilla, Jose Miguel Contador, Victor Augusto Vera Monge, Oscar Ramos, Alejandro Rodríguez, Ana Rodríguez Campello, Gemma Romeral Ballester, Mireia Llop Trujillano, Eva Giralt Steinhauer, Elisa Cuadrado Godia, Angel Javier Ois Santiago, Jordi Jimenez Conde, Joan Martí Fábregas, Daniel Guisado, Luís Prats, Pol Camps, Raquel Delgado, Alejandro Martínez Domeño, Rebeca Marín, David Cànovas, Jordi Estela, Marta Ros, Sonsoles Aranceta, Jordi Espinosa, Marta Rubio, Cristina Lafuente, Oriol Barrachina, Alicia Anguita, Anna Reverter, Carmen García, Gemma Sansa, Mariona Hervas, Monica Crosas, Tania Delgado, Dra Sonia Huertas Folch, Gemma Muñoz Gamito, Josep Trenado Alvarez, Teresa Subirana, Jessica Molina, Laura Comes Romero, Gemma Guardia Valls, Miriam Jover, Javier Joaquín Sotova, Sonia Mª García Sánchez, Sebastian Valenzuela, Juan José Mengual, M. Àngels Font, Mª Isabel Gómez Ruiz, Irati Zubizarreta, Susana Fernández González, Laura Gubieras, Carmen E. Cobos, Luis Mena Romo, Nuria Caballol, Luis Cano, Joaquín Serena Leal, Yolanda Silva Blas, Irene Bragado Trigo, Saima Bashir Viturro, Laura Pardo Albiñana, Montserrat Reina Garrido, Carla Marco Cazcarra, Karol Enrique Uscamaita, Fabian Márquez, Cristina Coll, Mar Irida Lloret Villlas, Berta Solano Vila, Berta Alemany Perna, Daniel López Domínguezl, Mercedes de Lera, Anna Cots Foraster, Urszula Bojaryn, Ikram Benabdelhak, Gerard Mauri Capdevila, Jordi Sanahuja Montesinos, Daniel Vázquez, José Vicente Hervás, Cristina González, Alejandro Quílez, Mikel Vicente Pascual, María Ruiz, Yolanda Riba, M. Pilar Gil Villar, Cristina García, Xavier Ustrell Roig, Mònica Baldrich Mora, Anna Pellisé Guinjoan, Judit Borras, Alba Mañé Martínez, Rafael Marés, Jaume Viñas i Gaya, Laia Seró, Paula Rodríguez, Gislaine Castilho, Angela Monterde Ortega, Silvia Reverté, Joan Josep Baiges, Gisela Martín Ozaeta, Sonia Escalante, Patricia Esteve Belloch, Iago Payo, Júlia Saura Salvado, Josep M Soler Insa, Ester Tio Vilamala, Josep Abos Navarro, Héctor Cruz Tabuenca, Tamara Canento Sánchez, Elisabet Roldán, Elsa Puiggrós Rubiol, Elisabet Franquet, Lidia Fuentes, Javier Donaire, Elena Martí, Laura Giménez, Junior Gil Vázquez, Eloisa Nieto Clara Gris Ambrós, Puri Rodríguez, José Félix Oletta, Pilar Pons Mellado, Bárbara Gómez, Vergilin Raileau, Oscar Pardina, Jordi Mercadal, María López-Diéguez, Pilar Pérez, Lourdes Gabarró, María Orriols, José Carlos Molina, Joan Josep Canet, Mireia Roca, Muriel Álvaro, Francesc Boneu, Georgina Giménez, Jaume Albà, Francesc Gibert, Jéssica Garcia, Patricia Barragan, Gustavo Jurado, Vanesa Pascual_Medicina Interna, Josep Sabaté Ortega, Joan Amaurys Martínez Solano, Víctor Fernández, Mónica Torres, Ana Belén Montero Alvaredo, Laura Redondo Parejo, Josep Maria Aragonés, Anna Bullón, Cora Loste, Paula González, Neker Bejarano, Francisco Sanchez, Gianni Lucchetti, Xavier Pla, Dr Javier Gimeno, Esteban Reynaga, Montse Barcons, Gabriel Celedón, Juan Ortiz, Dr Goran Anastasovski, Dr Oscar Mascaró, Dr Javier Diez de los Ríos, Meritxell Feliu, Anna Ribera, Cristhian Ruiz, Gerard Corominas, Dra Daniella Nunes, Claudia Roca, Nadina Latorre, Lizbeth Yataco, Maricelys Cruz, Nerea Blanco, Santiago Castejón, Claustre Pont Sunyer, Jordi Espinosa Garcia, Rodrigo Paz Martin, Albert de Luis Sanchez, Dolores Espinosa Vivas, Juan Valencia Molina, Planels Palome, Laia Tomas Chaume, Ares Villagrasa Vilella, Marco Bustamante, Anunciación Boltes, Fernando Rodríguez, Itziar Arrieta, Jordi Ciurans Molist, Barnés Andreu, Ernest Palomeras Soler, Nicolau Guanyabens Buscà, Manuel Daza López, Jordi Bigas Farreres, Virginia Casado Ruiz, Desiree Muriana Batiste, Mª Pilar Sanz Cartagena, Eulalia Cabot de Vega, Josep Bassa Real, Hector Pelaez Roman, César Socolich, Josep Mª Alonso Camp, Antonio Tomás Cano Orgaz, Mª Pilar Fossas Felip, Nicolás Morón, Sandra Bacca, Mauricio Molina, Francesc Casarramona, Lorena Elias, Muhammad Zidane Bukaei, Jose Antonio Martos Gutierrez, Judith Lopez Escuin, Cristina Olaizola, Yolexis López Vargas, Juan Jiménez Oyonarte, Rashida Soultana, Eduardo Sanjurjo Golpe, Esther Salvador, Guillem Vila, Marcos Serrano, Matilde Nuria López Claverol, Marian Lamolla, Miquel Amate, Adriana Rodriguez, Ruth Romero, Montgomery del Carpio, Ana Isabel Hernandez, Julián Martín, M Carmen Rosas, Antonio Nogueroles, Sorilandy Encarnación, Augusto Robles, Jose Antonio Herrera, Roger Gavilán, Toghrol Mameghani, Gastón Araujo, M.Angeles Garrido Morales, Enric Ramon Albert Segui, Eva Fernandez Climent, Francesc Paris Pujol, Mireia Judit Garrofé Seira, Lucía Gómez Pía, Fernando Salleres Nuñez, Cristina Aguar Peñalver, Cristina Vaz Lopes, Elisenda Ribera Tasa, Carmen Repullo Vilchez, Modesto Sánchez Zambrana, Beatriu Suescun Ribas, Inés Vilà Panés, Montserrat Vila Planavila, Alicia Vaqueiro Lorenzo, Meritxell Sabartés Guixes, Jorge Medina, David Sambrano, Javi Zamarreño, Carmen Pirela, Paola Vélez, Luis Cajamarca, Honey Pérez, Yarles Martínez, Jesus Alexander Gonçalves, Carles Regordosa, Claudia Mormeneo, Laura Griu, Maria Francia Colina, Enric Farik, Dolors Carrión Duch, Carles Badenas, Oscar Bernal, Núria Agramunt, Shyrlei Morales, Victoria Reynoso, Miguel Guerrero, Primitivo Romera Cid, Mònica Folqué, Claudia Pedroza, Adnan Hachem, Íñigo Soteras Martínez, Xavier Verdera García, Mercè López Amorós, Xavier Costa Subirós, Marta Cufí Benet, Cecile Van Eendenburg, Teresa Osuna, Dra Gina Santos, Dra Mireia Pallisera, Dr Lluís Gonzalo Oliva, Dra Gemma Sanchez, Dr Xavier Basurto, Dr Ludgi Vivoda, Dr Richard Van der Kleyn, Dra Laura Robles, Ana Cabanelas Barranco, Mª Cruz Almendros, Marc Pérez Oliveras, Amelia Fernández Álvarez, Maria Rybyeva, Antoni Viñas, Maria Barcons, Joaquim Danès Alberto Tavera, Pablo Burbano, Cintie López, David Cruz, Paula Bisbe, Nora Fernández, Juan Carlos Palacio, Eduardo Fraiz, Oriol Aguiló, Rollmy Amorodjo, John Velázquez, Elena Sánchez, Jaume Español, Judit Perez de Celis, Anna Coll, Glòria Díaz, Margarida Vergés i Sala, Mª Ángels Casas Capdevila, Yosmairy Yoselin Ferrini, Aitor Gorriz, Diego-Javier Cucurell Navarro, Dulce Velásquez, Jaume Pla Soler, Josep González, Julian David Higuera, Lina Cuellar, Liza Margarita Miniello, Lluis Pujol, Sorin Cracan, Mora Vives, M Angela, Lopez Lopez, Montse Gorchs Molist, Delofeu Anna, Silvia Solà Muñoz, Ferreres Yolanda, Carol Pujalte, Elisabeth Téllez Marín, Yolanda Font Casas, Sara Hernández Luque, Joaquim Mejias Sendra, Francesca Mellado Valero, Campos Escala, Galup De Lacanal, Lopez Diaz, Castillo Paramio, Català Estopà, Español Moreda, Calafell Majo, Carballo Almeida, Castro Naval, M Elena, Cregut Ruiz, Pere Lluis, Deulofeu Font, Fabregat Sanjuan, Joan Pere, Fontquerni Gorchs, Forés Bellés, Joan Antoni, Gomez Herrera, Juan Carlos, Hijazo Prades, Itzaina Torvisco, Marti Rovira, Obiols Gonzalez, Olive Cavero, Querol Gil, M Soledad, Rico Rodriguez, Rios Sambernardo, Ropero Molina, Jose Ramon, Sanchez Valero, Santos Arevalo, Maria Jose, Soto Garcia, Maria Angeles, Tebar Escribano, Torres Garcia, Pedro José, Verdes Carrion, M Isabel, Verge Lopez, Juan Jose, Lopez Canela, M Angeles, Lucas Guarque, Morales Alvarez, Jorge Arnulfo, Morell Fornieles, Subirats Gomez, Maria Teresa, Torello Masa, Miquel, Val Lopez, Maria Mercedes, Palmero Reyes, Juan Manuel, Rodriguez Forne, Ruana Turiel, Sanchez Gonzalez, Sebastia Gornals, Abrio Rico, Albert Gual Falip, Aznar Oliveros, Brugues Perotti, Calvet Molinero, Catells Franco, Corrales Medina, Daroca Miro, Duran Marquez, Feliu Pradas, Figueras Casanova, Garcia Tortajada, Grajera Gallego, Azahara del Mar, Las Arroyo, Dulcenombre de Jesus, Laserreta Sanz, Llambrich Vidal, Monllao Corral, Morales de la Cruz, Moreno Blanco, Orejuela Orgaz, Piñana Suazo, Pons Minguillon, Rodríguez Gómez, José Carlos, Rodriguez Pereira, Sedo Porcel, Anna, Sevil Villar, Sierra Lopez, Torres Romero, Trepat Calveres, Anna, Ventura Arnella, Acera Gil, M Teresa, Biesot Vico, Castro Galea, Rosa Maria, Escorcia Chafer, Juan Antonio, Gil Faure, Hernandez Luque, Jimenez Delgado, Mallafre Gay, M. Angel, Olivares Sanzo, Pubill Fondevila, Sabate Fort, Segovia Agámez, Antonio Carlos, Turata Longaretti, Valle Hernandez, Trayner Guixens, Aguilar Valor, Aguirre Alvarez, Alastrue Naval, Alferez Baquero, Alonso Marne, Aloy Orozco, Alvarez Colino, Alvarez Peñuela, Ameller Cirilo, Maria Vanessa, Andujar Guerrero, Estefania Remedios, Auladell Sillero, Azcarate Sorbet, Basany Genesca, Benavent Barduena, Benito Tudela, Blanch Pardo, Boluda Pla, Bonilla Gonzalez, Bru Serramalera, Burnat Andreu, Caballero Calvo-Rayo, Calvo Casellas, Camps Mombiela, Cano Bresme, Carcelen Fernandez, Caro Solà, Casasas Matavacas, Castanedo Bolado, Cerdeña Cortina, Abella Jane, Laia Collado Borrego, Colom Orri, Comellas Vilanova, Conillera Sole, Cots Torres, Cuchi Estepa, Marc de Sostoa Graell, Laura del Rio Lopez, Delgado Compte, Diaz Bueno, Diaz Maneiro, Andrea Lucia, Domenech Palau, M. Carme, Duran Carasso, Pablo Javier, El Abidi, Escoda Martin, Esteve Casanovas, Fernandez Perez, Ferre Quintero, Flores Escobar, Fontcuberta Abad, Fortes del Valle, Mª Luisa, Franco Quesada, Sara Maria, Franco Romero, Gallego Francisco, Gamiz Gala, Garcia Castañeda, Garcia Rodriguez, Casajuana Gemma, Gomez Arroyo, Gomez Girbau, Gonzalez Fernandez, Gonzalez Gonzalez, Gonzalez Lopez, Gual Obeso, Guerrero Blanco, Guillemas Roca, Guillermo Eudaldo, Sebastia Hernandez, Homar Covas, Hostench Alvarez, Huerta Royo, Ibañez Barcelo, Izquiero Cruz, Jaione Urdangarin Etxetxikia, Juárez Gimenez, Khlifi Alami, Laparra Gasco, Lara Moreales, Lasaosa Medina, Maria Lourdes, Lazaro Cava, Leon Berrar, López Maturana, Lopez Ramirez, López Romero, Lorente Marco, Lorenzo Martin, Lozano Casals, Lujan Nicola, Madrid Diaz, Jose Antonio, Maria Teresa Peris Morales, Marti Clemente, Martinez Castaño, David Natanael, Martinez Gamez, Martinez Gonzalez, Martinez Quesada, Maria de la Cabeza, Marzà Fusté, Melendo Lasheras, Miralles Mestre, Montserrat Puig Pastalle, Montserrate Vidal, Mora Mellado, Morales Ponce, Morera Cabre, Morera Vivet, Mundi Souza, Muñoz Quiles, Navea Rosa, Neira Iglesias, M Asuncion, Nuñez Manrique, Mª Pilar, Obiols Martinez, Pallares Reig, Partegas Torres, Pascual Berengueras, Perez Gamez, Perez Oset, Perez Restrepo, Maria Alejandra, Planas Yeste, Planells Mangado, Puertas Carbonell, Quinteiro Blanco, Rebollar Benavente, Recasens Fernandez, Reyes Gomez, Maria del Carmen, Roca Pou, Rodriguez Ferrer, Rodriguez Franco, Rodriguez Fuertes, Rodriguez Muñoz, Rodriguez Navarro, Roig Iniesta, Romero Gracia, Rovira Brunet, Rovira de Eugenio, Rubio Baena, Ruiz Llorens, Sala Llamazares, San Juan Alaez, Sanchez Segura, Santasusana Soldevilla, Sanz Salmeron, Segura Perez, Serra Balcells, Sorina Dumitras, Teixidor Montoya, Tena Vicente, Tierno Salinas, Ester Ines, Toledo Testa, Tomàs Figueras, Tomas Ruperez, Torrano Garcia-Penche, Torres Esparza, Vazquez Blanco, Vazquez De la Paz, Vazquez Gil, Vazquez Gonzalez, Vidal Meler, Vilalta Cots, Vilches Jimenez, Visser Fernandez, Viu Gavin, Vives Vives, Carmona Jimenez, Francisco Jose, Galobardes Vilches, Gonzalez Gomez, Jodar Manzanera, Marimon Cortes, Marrodan Orive, Martin Bosch, Martorell Lopez, Millares Roca, M Jesus, Miralles Guri, Muliterno Hernandez, Muñoz Oliva, Pons Pujol, Postius Conde, Prieto Arruñada, Quintana Mathé, Rosell Mata, Alvarin Alvarez, Arrufat Flores, Bañuelos Pago, Campo Vilar, Cardus Hidalgo, Castello Gil, Maria Gloria, Castrillo Montsesinos, Clave Garces, Comes Sanroma, Descalzo Sequi, Errando Ricol, Escudero Campillo, Maria del Mar, Fernandez Alvarez, Fernandez Gomez, Franch Espinosa, Freixes Graells, Garcia Plaza, Garcia-Marron Gallego, Hernandez Simancas, Jaraba Armas, Jimenez Ramos, Lopez Oganissian, Madrona Romero, M Rosa, Martinez Millan, Martínez Morón, Merchan Encinas, Moreno Jimenez, Muñoz Rico, Navarro Rodriguez, Nogales Ibañez, Rita Maria, Novillo Viera, Parella Torrabadella, Mari Alba, Pera Villar, Carla Montserrat, Rabella Miralles, Ramis Trilles, Ribera Ortiz, Sastre Perez, Soro Borrega, Tapia Fores, Tellez Bernad, Trenado Alvarez, Felix Martin, Herrero Perez, Lanau Fuster, Lopez Gomariz, Pardo Lozano, Quintana Altimiras, Ventosa Lopez, Almodovar Damian, Alvarez Monterroso, Arambudo Comas, Boullon Garzon, Burgos Capella, Campuzano Garcia, Maria Del Mar, Capdevila Olivas, Carre Marti, Clara Isabel, Carretero Bacaicoa, Cazorla Calderon, Chacon Osuna, Cortes Planas, Cortit Olio, Delhomme Estany, Fructuos Martinez, Garcia Lopez, Pascual Luis, Genis Amill Vallve, Gonzalez Muñoz, Hernaez Ventura, Lavernia Gimenez, Martin Rojo, Martínez Medina, Mayol Barrera, Mercader Pi, Merino Dalmau, Miguel Campodarbe, Moreno Sanchez, Francisco Javier, Penela Barrameda, Prieto Ajenjo, Rodriguez Pareja, Rodríguez Piñar, Rodriguez Tello, Romero Pereda, Sainz Saborido, Santacana Martin, Santos Martinez, Sierra Chavez, Turbau Torres, Vicente Domenech, Villena Esteo, Vives Pertegaz, Baena Gonzalez, Bagaria Pont, Beltran Sanchez, Bonet Alarcon, Borch Ballescà, Buhils Clanchet, Closa Garcia, Colomina Carril, Cristina Fernandez Sanchez, Edurne Judith Fernandez Toledo, Espases Rodriguez, Espert Resa, F Xavier, Fernández Sol, Gonzalez Lugo, Gracia Llesera, Herrada Lendinez, Juliench Liesa, Sandra Alicia, Lopez Ortega, Lopez Yuste, Lozano Villanueva, Lucia Sola Soto, Madrid Castellano, Megias Cano, Daniel Jesus, Montasell Ponce, Montesinos Sospedra, Moya Martinez, Muñoz Herrera, Ocaña Fernandez, Palau Bernal, Perez Sole, Ramon Carbonell, Ribas Lop, Rubio López, Rueda Lopez, Sabat Castaño, Sabata Lara, Salmerón Ramírez, Serra Creus, Serrano Dalmau, Sumasi Mainero, Gonzalo Gabriel, Torello Masa, Valencia Primo, Ana Maria Viñuales Muñoz, Josep Roig, and Verònica Hidalgo

Subjects
Advanced and Specialized Nursing, Neurology (clinical), Cardiology and Cardiovascular Medicine
Abstract

Background: We aim to assess whether time of day modified the treatment effect in the RACECAT trial (Direct Transfer to an Endovascular Center Compared to Transfer to the Closest Stroke Center in Acute Stroke Patients With Suspected Large Vessel Occlusion Trial), a cluster-randomized trial that did not demonstrate the benefit of direct transportation to a thrombectomy-capable center versus nearest local stroke center for patients with a suspected large vessel stroke triaged in nonurban Catalonia between March 2017 and June 2020. Methods: We performed a post hoc analysis of RACECAT to evaluate if the association between initial transport routing and functional outcome differed according to trial enrollment time: daytime (8:00 am –8:59 pm ) and nighttime (9:00 pm –7:59 am ). Primary outcome was disability at 90 days, as assessed by the shift analysis on the modified Rankin Scale score, in patients with ischemic stroke. Subgroup analyses according to stroke subtype were evaluated. Results: We included 949 patients with an ischemic stroke, of whom 258 patients(27%) were enrolled during nighttime. Among patients enrolled during nighttime, direct transport to a thrombectomy-capable center was associated with lower degrees of disability at 90 days (adjusted common odds ratio [acOR], 1.620 [95% CI, 1.020–2.551]); no significant difference between trial groups was present during daytime (acOR, 0.890 [95% CI, 0.680–1.163]; P interaction =0.014). Influence of nighttime on the treatment effect was only evident in patients with large vessel occlusion(daytime, acOR 0.766 [95% CI, 0.548–1.072]; nighttime, acOR, 1.785 [95% CI, 1.024–3.112] ; P interaction P interaction >0.1 for all comparisons). We observed longer delays in alteplase administration, interhospital transfers, and mechanical thrombectomy initiation during nighttime in patients allocated to local stroke centers. Conclusions: Among patients evaluated during nighttime for a suspected acute severe stroke in non-urban areas of Catalonia, direct transport to a thrombectomy-capable center was associated with lower degrees of disability at 90 days. This association was only evident in patients with confirmed large vessel occlusion on vascular imaging. Time delays in alteplase administration and interhospital transfers might mediate the observed differences in clinical outcome. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02795962.

Published
2023
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7. Identification of Usutu Virus Africa 3 Lineage in a Survey of Mosquitoes and Birds from Urban Areas of Western Spain

Author

Bravo-Barriga, Daniel, Ferraguti, Martina, Magallanes, Sergio, Aguilera-Sepúlveda, Pilar, Llorente, Francisco, Pérez-Ramírez, Elisa, Vázquez, Ana, Guerrero-Carvajal, Fátima, Sánchez-Seco, María Paz, Jiménez-Clavero, Miguel Ángel, Mora-Rubio, Carlos, Marzal, Alfonso, Frontera, Eva, de Lope, Florentino, Fundación BBVA, Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Junta de Extremadura, European Commission, Ministerio de Universidades (España), Bravo-Barriga, Daniel, Ferraguti, Martina, Magallanes, Sergio, Aguilera-Sepúlveda, Pilar, Llorente, Francisco, Pérez-Ramírez, E., Vázquez, Ana, Guerrero-Carvajal, Fátima, Sánchez-Seco, María Paz, Jiménez-Clavero, Miguel Ángel, Mora-Rubio, Carlos, Marzal, Alfonso, and Frontera, Eva

Subjects
Article Subject, General Veterinary, General Immunology and Microbiology, General Medicine
Abstract

10 Pág., Usutu virus (USUV) is an emerging zoonotic arbovirus that has caused an increasing number of animal and human cases in Europe in recent years. Understanding the vector species and avian hosts involved in the USUV enzootic cycle in an area of active circulation is vital to anticipate potential outbreaks. Mosquitoes were captured in 2020, while wild birds were sampled in both 2020 and 2021 in Extremadura, southwestern Spain. The presence of USUV in the mosquito vectors was assessed by a real-time reverse transcription-polymerase chain reaction (rRT-PCR) assay and confirmed by sequencing amplicons from two generic RT-PCR sets for flaviviruses. Sequences were analysed phylogenetically. Bird sera were screened for flavivirus antibodies with a blocking ELISA kit and subsequently tested for virus-specific antibodies with a micro-virus-neutralization test. Overall, 6,004 mosquitoes belonging to 13 species were captured, including some well-known flavivirus vectors (Culex pipiens, Cx. perexiguus, and Cx. univittatus). Of the 438 pools tested, USUV was detected in two pools of Cx. pipiens. Phylogenetic analysis using a fragment of the NS5 gene assigned the USUV detected the Africa 3 lineage. Out of 1,413 wild birds tested, USUV-specific antibodies were detected in 17 birds (1.2%, 10 males and 7 females) from eight species. The first detection of USUV Africa 3 lineage in mosquitoes from Spain, together with serologically positive resident wild birds in urban and rural areas, indicates active circulation and a possible risk of exposure for the human population, with necessity to establish specific surveillance plans., This study was funded from Ayudas Fundación BBVA a Equipos de Investigación Científica 2019 (PR (19_ECO_0070)), Research State Agency Project (PID2020-116768RR-C21/C22), Instituto de Salud Carlos III (PI19CIII_00014), Consejería de Economía e Infraestructura of the Junta de Extremadura, and the European Regional Development Fund, a Way to Make Europe, through the research project under grant numbers IB20089, GR21122, and GR21084. MF was supported by a Juan de la Cierva 2017 Formación contract (FJCI-2017-34394) from the Spanish Ministry of Science, Innovation and Universities, and she is currently funded by the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie grant agreement no. 844285, “EpiEcoMod.” CMR was funded by a FPU grant from the Ministry of Universities of Spain (reference: FPU20/01039). FGC was supported by “Ayudas a la Formación Investigador Predoctoral 2018” Formative contract (PD18056) from the Extremadura Regional Government.

Published
2023
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8. POSIBLE DEPREDACIÓN DE Liolaemus torresi (IGUANIA: LIOLAEMIDAE) SOBRE LA POLILLA NATIVA Hyles annei (LEPIDOPTERA: SPHINGIDAE)

Author

Marta Mora Espinoza, Bernardo Segura Silva, Felipe Mora Esquivel, and Antonieta Labra Lillo

Subjects
Animal Science and Zoology, Ecology, Evolution, Behavior and Systematics
Abstract

Reportamos la primera evidencia que sugiere que el lagarto Liolaemus torresi podría consumir al insecto nativo, la polilla esfinge Hyles annei.

Published
2023
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10. FOCUSED EVALUATION WITH ULTRASOUND IN THORACOABDOMINAL TRAUMA

Author

Darwin Daniel Campos González, Luis Alonso Arciniega Jácome, Alexander Oswaldo Ojeda Crespo, María Belén Alvarado Mora, María Fernanda Alvarado Mora, Dayan Leiner Zambrano Cabrera, Selena Belén Romero Macías, Rossi Dayana Ramírez Apolo, Karla Vanessa Soto Paucar, Rene Adolfo Salinas Paucar, Gloria Anabel Ortíz Cruz, and Karen Selena Sánchez Valladolid

Published
2023
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11. Search for photons above 1019 eV with the surface detector of the Pierre Auger Observatory

Author

Abreu, P., Aglietta, M., Allekotte, I., Almeida Cheminant, K., Almela, A., Alvarez-Muñiz, J., Ammerman Yebra, J., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Araújo Ferreira, P. R., Arnone, E., Arteaga Velázquez, J. C., Asorey, H., Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Balaceanu, A., Barbato, F., Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Bonneau Arbeletche, L., Borodai, N., Brack, J., Bretz, T., Brichetto Orchera, P. G., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Caccianiga, L., Caracas, I., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cobos Cerutti, A. C., Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Contreras, F., Convenga, F., Correia Dos Santos, D., Covault, C. E., Cristinziani, M., Dasso, S., Daumiller, K., Dawson, B. R., De Almeida, R. M., De Jesús, J., De Jong, S. J., De Mello Neto, J. R. T., De Mitri, I., De Oliveira, J., De Oliveira Franco, D., De Palma, F., De Souza, V., De Vito, E., Del Popolo, A., Deligny, O., Deval, L., Di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Domingues Mendes, L. M., Dos Anjos, R. C., Ebr, J., Eman, M., Engel, R., Epicoco, I., Erdmann, M., Escobar, C. O., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Gómez Berisso, M., Gómez Vitale, P. F., Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kääpä, A., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Kizakke Covilakam, V. V., Klages, H. O., Kleifges, M., Kleinfeller, J., Knapp, F., Krohm, N., Kunka, N., Lago, B. L., Langner, N., Leigui De Oliveira, M. A., Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Lo Presti, D., Lopes, L., López, R., Lu, L., Luce, Q., Lundquist, J. P., Machado Payeras, A., Mancarella, G., Mandat, D., Manning, B. C., Manshanden, J., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Martínez Bravo, O., Martins, M. A., Mastrodicasa, M., Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Melo, D., Menshikov, A., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Müller, A. L., Mulrey, K., Mussa, R., Muzio, M., Namasaka, W. M., Nasr-Esfahani, A., Nellen, L., Nicora, G., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Norwood, I., Nosek, D., Novotny, V., Nožka, L., Nucita, A., Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Pawlowsky, J., Pech, M., Pȩkala, J., Pelayo, R., Pereira Martins, E. E., Perez Armand, J., Pérez Bertolli, C., Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Pourmohammad Shavar, M., Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., Rodrigues De Carvalho, W., Rodriguez Rojo, J., Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Sanabria Gomez, J. D., Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schlüter, F., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Straub, M., Streich, A., Suárez-Durán, M., Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Szadkowski, Z., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Todero Peixoto, C. J., Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Ulrich, R., Unger, M., Vaclavek, L., Vacula, M., Valdés Galicia, J. F., Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Vergara Quispe, I. D., Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., Zavrtanik, M., Zehrer, L., Abreu, P., Aglietta, M., Allekotte, I., Almeida Cheminant, K., Almela, A., Alvarez-Muniz, J., Ammerman Yebra, J., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Araujo Ferreira, P. R., Arnone, E., Arteaga Velazquez, J. C., Asorey, H., Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Balaceanu, A., Barbato, F., Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blumer, J., Bohacova, M., Boncioli, D., Bonifazi, C., Bonneau Arbeletche, L., Borodai, N., Brack, J., Bretz, T., Brichetto Orchera, P. G., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Busken, M., Bwembya, A., Caballero-Mora, K. S., Caccianiga, L., Caracas, I., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cobos Cerutti, A. C., Colalillo, R., Coleman, A., Coluccia, M. R., Conceicao, R., Condorelli, A., Consolati, G., Contreras, F., Convenga, F., Correia Dos Santos, D., Covault, C. E., Cristinziani, M., Dasso, S., Daumiller, K., Dawson, B. R., De Almeida, R. M., De Jesus, J., De Jong, S. J., De Mello Neto, J. R. T., De Mitri, I., De Oliveira, J., De Oliveira Franco, D., De Palma, F., De Souza, V., De Vito, E., Del Popolo, A., Deligny, O., Deval, L., Di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Domingues Mendes, L. M., Dos Anjos, R. C., Ebr, J., Eman, M., Engel, R., Epicoco, I., Erdmann, M., Escobar, C. O., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fick, B., Figueira, J. M., Filipcic, A., Fitoussi, T., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., Garcia, B., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Gomez Berisso, M., Gomez Vitale, P. F., Gongora, J. P., Gonzalez, J. M., Gonzalez, N., Goos, I., Gora, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Hojvat, C., Horandel, J. R., Horvath, P., Hrabovsky, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kaapa, A., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Kizakke Covilakam, V. V., Klages, H. O., Kleifges, M., Kleinfeller, J., Knapp, F., Krohm, N., Kunka, N., Lago, B. L., Langner, N., Leigui De Oliveira, M. A., Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Lo Presti, D., Lopes, L., Lopez, R., Lu, L., Luce, Q., Lundquist, J. P., Machado Payeras, A., Mancarella, G., Mandat, D., Manning, B. C., Manshanden, J., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Maris, I. C., Marsella, G., Martello, D., Martinelli, S., Martinez Bravo, O., Martins, M. A., Mastrodicasa, M., Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Melo, D., Menshikov, A., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Muller, A. L., Mulrey, K., Mussa, R., Muzio, M., Namasaka, W. M., Nasr-Esfahani, A., Nellen, L., Nicora, G., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Norwood, I., Nosek, D., Novotny, V., Noa3/4ka, L., Nucita, A., Nunez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Pawlowsky, J., Pech, M., Pekala, J., Pelayo, R., Pereira Martins, E. E., Perez Armand, J., Perez Bertolli, C., Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Pourmohammad Shavar, M., Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., Rodrigues De Carvalho, W., Rodriguez Rojo, J., Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Sanabria Gomez, J. D., Sanchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schafer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schluter, F., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovanek, P., Schroder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Smau, R., Smida, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanca, D., Stanic, S., Stasielak, J., Stassi, P., Straub, M., Streich, A., Suarez-Duran, M., Sudholz, T., Suomijarvi, T., Supanitsky, A. D., Szadkowski, Z., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Todero Peixoto, C. J., Tome, B., Torres, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Ulrich, R., Unger, M., Vaclavek, L., Vacula, M., Valdes Galicia, J. F., Valore, L., Varela, E., Vasquez-Ramirez, A., Veberic, D., Ventura, C., Vergara Quispe, I. D., Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczynski, H., Wittkowski, D., Wundheiler, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., Zavrtanik, M., and Zehrer, L.

Subjects
Astronomy, Experimental High Energy Physics, Astronomy and Astrophysics, High Energy Physics, ddc:620, cosmic ray experiments, gamma ray detectors, ultra high energy cosmic rays, ultra high energy photons and neutrinos, Engineering & allied operations
Abstract

We use the surface detector of the Pierre Auger Observatory to search for air showers initiated by photons with an energy above 1019 eV. Photons in the zenith angle range from 30∘ to 60∘ can be identified in the overwhelming background of showers initiated by charged cosmic rays through the broader time structure of the signals induced in the water-Cherenkov detectors of the array and the steeper lateral distribution of shower particles reaching ground. Applying the search method to data collected between January 2004 and June 2020, upper limits at 95% CL are set to an E-2 diffuse flux of ultra-high energy photons above 1019 eV, 2 × 1019 eV and 4 × 1019 eV amounting to 2.11 × 10-3, 3.12 × 10-4 and 1.72 × 10-4 km-2 sr-1 yr-1, respectively. While the sensitivity of the present search around 2 × 1019 eV approaches expectations of cosmogenic photon fluxes in the case of a pure-proton composition, it is one order of magnitude above those from more realistic mixed-composition models. The inferred limits have also implications for the search of super-heavy dark matter that are discussed and illustrated.

Published
2023

12. Road users’ behaviour in the '30 km/h zones'. The case study of Bologna

Author

Pazzini, Margherita, Lantieri, Claudio, Vignali, Valeria, Dondi, Giulio, Giovannini, Alice, Mora, Andrea, Pazzini, Margherita, Lantieri, Claudio, Vignali, Valeria, Dondi, Giulio, Giovannini, Alice, and Mora, Andrea

Subjects
General Medicine, 30 km/h zones, vulnerable road users, traffic calming measures, excessive vehicle speeds
Abstract

Excessive vehicle speeds in urban areas have resulted to be a major cause of road accidents involving pedestrians, cyclists, and motorcyclists, identified as "vulnerable road users" (VRU). A possible useful strategy to overcome this problem, both reducing speed and safeguarding vulnerable road users (VRU), is the introduction of "30 km/h zones". As traffic calming measures, they allow a maximum speed for drivers of 30km/h. The purpose of this study is to monitor the behaviour of drivers in the “30 km/h zones” of the centre of Bologna. With the close collaboration of Bologna Municipality, the study has provided for the monitoring of speed and type of transport in specific points within a selected circuit. Data collected showed that, although in most of the selected zones, speeds are below 30 km/h, in the areas where traffic is heavier, drivers exceed the permitted limit.

Published
2023
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13. Phylogenetic analysis reveals that the H5N1 avian influenza A outbreak in poultry in Ecuador in November 2022 is associated with the highly pathogenic clade 2.3.4.4b

Author

Alfredo Bruno, Alonzo Alfaro-Núñez, Doménica de Mora, Rubén Armas, Maritza Olmedo, Jimmy Garcés, María Sol Vaca, Euclides De la Torre, David Jarrin, Lidia Burbano, Johanna Salas, Cristian Imbacuan, José Chanatasig, Margoth Barrionuevo, María Cristina Galante, Veronica Salas, Natalia Goñi, Juan Cristina, Christian Steffe Domingues, Lucas Oliveira Montesino, Fernanda Gomes Cardoso, Dilmara Reischak, and Miguel Angel Garcia-Bereguiain

Subjects
Microbiology (medical), Infectious Diseases, General Medicine
Published
2023
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18. Relation of serum BDNF to major depression and exploration of mechanistic roles of serum BDNF in a study of vitamin D3 and omega-3 supplements for late-life depression prevention

Author

Chirag M. Vyas, David Mischoulon, Grace Chang, Charles F. Reynolds, Nancy R. Cook, Alison Weinberg, Trisha Copeland, Vadim Bubes, Gary Bradwin, I-Min Lee, Julie E. Buring, Samia Mora, Nader Rifai, JoAnn E. Manson, and Olivia I. Okereke

Subjects
Psychiatry and Mental health, Biological Psychiatry
Published
2023
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21. Case-controlled field study of the ICD-11 clinical descriptions and diagnostic requirements for Bodily Distress Disorders

Author

Jared Keeley, Geoffrey M. Reed, Tahilia Rebello, Julia Brechbiel, Jose Angel Garcia-Pacheco, Kazeem Adebayo, Oluyomi Esan, Oluyinka Majekodunmi, Akin Ojagbemi, Lucky Onofa, Rebeca Robles, Chihiro Matsumoto, Maria Elena Medina-Mora, Cary S. Kogan, Maya Kulygina, Wolfgang Gaebel, Min Zhao, Michael C. Roberts, Pratap Sharan, Jose Luis Ayuso-Mateos, Brigitte Khoury, Dan J. Stein, Anne M. Lovell, Kathleen Pike, Francis Creed, and Oye Gureje

Subjects
Psychiatry and Mental health, Clinical Psychology
Published
2023
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26. Sequential oral antibiotic in uncomplicated Staphylococcus aureus bacteraemia: a propensity-matched cohort analysis

Author

Itziar Diego-Yagüe, Alberto Mora-Vargas, Jose Manuel Vázquez-Comendador, Beatriz Santamarina-Alcantud, Ana Fernández-Cruz, Elena Múñez-Rubio, Andrea Gutiérrez-Villanueva, Isabel Sanchez-Romero, Victor Moreno-Torres, Antonio Ramos-Martínez, and Jorge Calderón-Parra

Subjects
Microbiology (medical), Infectious Diseases, General Medicine
Published
2023
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27. Use of cidofovir in a patient with severe mpox and uncontrolled HIV infection

Author

Adam Stafford, Stephanie Rimmer, Mark Gilchrist, Kristi Sun, Ella P Davies, Claire S Waddington, Christopher Chiu, Darius Armstrong-James, Thomas Swaine, Frances Davies, Carlos H M Gómez, Vagish Kumar, Ahmad ElHaddad, Zaid Awad, Christopher Smart, Borja Mora-Peris, David Muir, Paul Randell, Joanna Peters, Meera Chand, Clare E Warrell, Tommy Rampling, Graham Cooke, Sara Dhanji, Vivienne Campbell, Carys Davies, Sana Osman, and Aula Abbara

Subjects
Infectious Diseases
Published
2023
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28. Whole genome analysis of Gram-negative bacteria using the EPISEQ CS application and other bioinformatic platforms

Author

Ulises Garza-Ramos, Nadia Rodríguez-Medina, Carlos Córdova-Fletes, Daira Rubio-Mendoza, Christopher J. Alonso-Hernández, Luis Esaú López-Jácome, Rao Morfín-Otero, Eduardo Rodríguez-Noriega, Fabián Rojas-Larios, María del Rosario Vázquez-Larios, Alfredo Ponce-de-Leon, Elena Victoria Choy-Chang, Rafael Franco-Cendejas, Bernardo Alfonso Martinez-Guerra, Cecilia Teresita Morales-de-La-Peña, Juan Pablo Mena-Ramírez, Eduardo López-Gutiérrez, Ricardo García-Romo, Bertha Ballesteros-Silva, Alejandro Valadez-Quiroz, Laura Karina Avilés-Benítez, José Manuel Feliciano-Guzmán, Talia Pérez-Vicelis, María del Consuelo Velázquez-Acosta, Cecilia Padilla-Ibarra, Laura Isabel López-Moreno, Reyna Edith Corte-Rojas, Carlos Antonio Couoh-May, María Angelina Quevedo-Ramos, Maribel López-García, Gabriela Chio-Ortiz, Mariana Gil-Veloz, Alejandro Molina-Chavarria, Javier Paul Mora-Domínguez, Daniel Romero-Romero, Francisco Javier May-Tec, and Elvira Garza-González

Subjects
Microbiology (medical), Immunology, Immunology and Allergy, Microbiology
Published
2023
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29. Registros documentados de la Tórtola Orejuda (Zenaida auriculata Des Murs, 1847; Aves: Columbidae) en Loreto – Perú

Author

Arturo Acosta Díaz, Rommel Roberto Rojas Zamora, Esteban Fong Rengifo, Walter Leonardo Vásquez Mora, and Gonzalo Hernández Mora

Subjects
General Medicine
Abstract

La Tórtola Orejuda Zenaida auriculata está ampliamente distribuida en las tierras bajas de la costa peruana y en los valles interandinos que van hasta los 4000 msnm frecuentemente asociados a ciudades o zonas agrícolas que favorecen el desarrollo de sus poblaciones. Los reportes en la Amazonía peruana son escasos y no documentados. En esta nota documentamos el registro de Z. auriculata en la ciudad de Iquitos.

Published
2022
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30. Salutogénesis y su relación con hábitos de alimentación, estilo de vida y condiciones ambientales en espacios laborales

Author

Melissa Salas Mora, Yorleni Chacón Sandi, and Sergio Mora Mora

Subjects
General Medicine
Abstract

Objetivo: Determinar el sentido de coherencia y estilo de vida de los colaboradores de una entidad bancaria en San José Costa Rica. Materiales y Métodos: Enfoque cuantitativo; estudio correlacional (analítico). Participaron 63 colaboradores (35 mujeres y 28 hombres) con edades entre los 19 y 41 años. Se aplicó una encuesta digital desde la aplicación de Google forms y se envió vía WhatsApp a diferentes departamentos del banco incluyendo la totalidad de trabajadores de la sucursal. Instrumentos: Se utilizó el Cuestionario de Orientación a la Vida (OLQ-13) o Escala del SOC: Instrumento propuesto como herramienta válida para aplicar medidas promotoras de salud, mide el sentido de coherencia interna, se aplicó un cuestionario de elaboración propia para evaluar el estilo de vida de los colaboradores, así como las condiciones ambientales laborales. Resultados: La prueba estadística aplicada confirma relación estadísticamente significativa entre la salutogénesis y las variables bajo estudio con los siguientes valores: Referente a estilo de vida, quienes realizan ejercicio físico, (P=0.002), tipo de ejercicio (P=0.039), y frecuencia (P=0.015). El consumo de agua, (P=0.01), tiempos de comida (P=0,016), y suplementación (P=0.032). En las molestias percibidas en el área de trabajo (P=0.016). Conclusiones: Se confirma que existe una relación entre la salutogénesis, el estilo de vida y las condiciones ambientales en espacios laborales.

Published
2022
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32. Workflows and Outcomes in Patients With Suspected Large Vessel Occlusion Stroke Triaged in Urban and Nonurban Areas

Author

Alvaro Garcia-Tornel, Monica Millan, Marta Rubiera, Alejandro Bustamante, Manuel Requena, Laura Dorado, Marta Olivé-Gadea, Xavier Jiménez, Angels Soto, Marisol Querol, Maria Hernández-Pérez, Meritxell Gomis, Pere Cardona, Xabier Urra, Francesc Purroy, Yolanda Silva, Xavier Ustrell, Patricia Esteve, Mercè Salvat-Plana, Miquel Gallofré, Carlos Molina, Antoni Dávalos, Tudor Jovin, Sonia Abilleira, Marc Ribo, Natalia Pérez de la Ossa, Marc Ribó Jacobi, Estela Sanjuan, Katherine Santana, Noelia Rodríguez, Jorge Pagola, David Rodriguez-Luna, Olga Maisterra, Estevo Santamarina, Marian Muchada, Jesús Juega, Sandra Boned, Antonio Palasi Franco, Álvaro García -Tornel, Matías Deck, Victoria Sala, Lucía Muñoz, Mónica Millán, Elena López-Cancio, María Hernández-Pérez, Jordi Ciurans, Daniela Samaniego, Tamara Canento, Lorena Martin, Anna Planas, Joaquin Broto, Agustín Sorrentino, Martí Paré, Nuole Zhu, Alicia Garrido, Laia Grau, Ane Miren Crespo, Silvia Presas, Miriam Almendrote, Alba Ramos, Giuseppe Lucente, Lourdes Ispierto, Manuel Lozano, Juan Luis Becerra, Marta Jiménez, Dolores Vilas Rolán, Nicolas Guanyabens, Josep Sanchez-Ojanguren, Alicia Martínez-Piñeiro, Sara Forcén, Mireia Gea, Marta Álvarez, Anna Ramos, Manuel Domínguez Lizarbe, Sara, Rubio Guerra, Irene Bragado, Andrea Arbex, Luis Rodríguez, Pere Cardona Portela, Helena Quesada García, Blanca Lara Rodríguez, Nuria Cayuela, Julia Miró, Clara Marzal, Andrés Paipa, Sergio Campoy, Ana Núñez, Pablo Arroyo, Sarah Besora, Vanessa Adell, Jaume Campdelacreu, Montse Alemany Martí, Belén González, Laura Bau Vila, Marta Fiter Crespo, Anna Berbel, Ma. Cristina Villaescusa Urbaneja, Núria Guillen, Nuria Vidal, Patricia Valentina Vérez Santamaria, Diego Herrero Navarro, Marta Simó, Mercedes Falip, Elisabeth Matas, Neus Mongay Ochoa, Ariadna Gifreu, Albert Muñoz, Lucía Romero, Eduard Portell, Guillermo Hernández Perez, F. Ruiz Esteve, Silvia Teixidor, Augusto Salazar Talavera, Roser Gómez, Xabier Urra Nuin, Martha Vargas, Ángel Chamorro, Sergio Amaro, Laura Llull, Arturo Renú, Salvatore Rudilosso, Raquel Sánchez del Valle, Helena Ariño, Nuria Solà, Delón la Puma, Francisco Gil, Juan Bernardo Gómez, Nuria Matos, Neus Falgàs, Sergi Borrego, Almudena Sánchez, Mircea Balasa, Carmen Montejo, Mar Guasp, David Reyes, Pablo Sánchez Cervilla, Jose Miguel Contador, Victor Augusto Vera Monge, Oscar Ramos, Alejandro Rodríguez, Ana Rodríguez Campello, Gemma Romeral Ballester, Mireia Llop Trujillano, Eva Giralt Steinhauer, Elisa Cuadrado Godia, Angel Javier Ois Santiago, Jordi Jimenez Conde, Joan Martí Fábregas, Daniel Guisado, Luís Prats, Pol Camps, Raquel Delgado, Alejandro Martínez Domeño, Rebeca Marín, David Cànovas, Jordi Estela, Marta Ros, Sonsoles Aranceta, Jordi Espinosa, Marta Rubio, Cristina Lafuente, Oriol Barrachina, Alicia Anguita, Anna Reverter, Carmen García, Gemma Sansa, Mariona Hervas, Monica Crosas, Tania Delgado, Jerzy Krupinski, Sonia Huertas Folch, Gemma Muñoz Gamito, Josep Trenado Alvarez, Teresa Subirana, Jessica Molina, Laura Comes Romero, Gemma Guardia Valls, Miriam Jover, Javier Joaquín Sotova, Sonia Mª García Sánchez, Sebastian Valenzuela (intensivista), Manuel Gómez-Choco, Juan José Mengual, M. Àngels Font, Mª Isabel Gómez Ruiz, Irati Zubizarreta, Susana Fernández González, Laura Gubieras, Carmen E. Cobos, Luis Mena Romo, Nuria Caballol, Luis Cano, Joaquín Serena Leal, Mikel Terceño Izarra, Irene Bragado Trigo, Saima Bashir Viturro, Laura Pardo Albiñana, Montserrat Reina Garrido, Carla Marco Cazcarra, Karol Enrique Uscamaita, Fabian Márquez, Cristina Coll, Mar Irida Lloret Villlas, Berta Solano Vila, Berta Alemany Perna, Daniel López Domínguezl, Mercedes de Lera, Anna Cots Foraster, Urszula Bojaryn, Ikram Benabdelhak, Gerard Mauri Capdevila, Jordi Sanahuja Montesinos, Daniel Vázquez, José Vicente Hervás, Cristina González, Alejandro Quílez, Mikel Vicente Pascual, María Ruiz, Yolanda Riba, M. Pilar Gil Villar, Cristina García, Xavier Ustrell Roig, Mònica Baldrich Mora, Anna Pellisé Guinjoan, Judit Borras, Alba Mañé Martínez, Rafael Marés, Jaume Viñas i Gaya, Laia Seró, Alan Flores, Paula Rodríguez, Gislaine Castilho, Angela Monterde Ortega, Silvia Reverté, Josep Zaragoza, Joan Josep Baiges, Gisela Martín Ozaeta, Sonia Escalante, Iago Payo, Júlia Saura Salvado, Natalia Mas Sala, Josep M Soler Insa, Ester Tio Vilamala, Josep Abos Navarro, Héctor Cruz Tabuenca, Tamara Canento Sánchez, Elisabet Roldán, Elsa Puiggrós Rubiol, Elisabet Franquet, Lidia Fuentes, Javier Donaire, Elena Martí, Laura Giménez, Junior Gil Vázquez, Eloisa Nieto Clara Gris Ambrós, Puri Rodríguez, José Félix Oletta, Pilar Pons Mellado, Catena, Bárbara Gómez, Vergilin Raileau, Esther Catena Ruíz, Oscar Pardina, Jordi Mercadal, María López-Diéguez, Pilar Pérez, Lourdes Gabarró, María Orriols, Joan Josep Canet, Mireia Roca, Muriel Álvaro, Francesc Boneu, Georgina Giménez, Jaume Albà, Francesc Gibert, Jéssica Garcia, Patricia Barragan, Gustavo Jurado, Josep Sabaté Ortega, Joan Amaurys Martínez Solano, Víctor Fernández, Mónica Torres, Ana Belén Montero Alvaredo, Laura Redondo Parejo, Josep Maria Aragonés, Anna Bullón, Cora Loste, Paula González, Neker Bejarano, Francisco Sanchez, Gianni Lucchetti, Xavier Pla, Javier Gimeno, Esteban Reynaga, Montse Barcons, Gabriel Celedón, Juan Ortiz, Goran Anastasovski, Oscar Mascaró, Javier Diez de los Ríos, Meritxell Feliu, Anna Ribera, Cristhian Ruiz, Gerard Corominas, Daniella Nunes, Claudia Roca, Nadina Latorre, Lizbeth Yataco, Maricelys Cruz, Nerea Blanco, Santiago Castejón, Dolores Cocho Calderón, Claustre Pont Sunyer, Jordi Espinosa Garcia, Rodrigo Paz Martin, Albert de Luis Sanchez, Dolores Espinosa Vivas, Juan Valencia Molina, Gemma, Planels Palome, Laia Tomas Chaume, Ares Villagrasa Vilella, Marco Bustamante, Anunciación Boltes, Fernando Rodríguez, Itziar Arrieta, Jordi Ciurans Molist, Barnés Andreu, Ernest Palomeras Soler, Nicolau Guanyabens Buscà, Manuel Daza López, Jordi Bigas Farreres, Virginia Casado Ruiz, Desiree Muriana Batiste, Mª Pilar Sanz Cartagena, Eulalia Cabot de Vega, Josep Bassa Real, Hector Pelaez Roman, César Socolich, Josep Mª Alonso Camp, Antonio Tomás Cano Orgaz, Mª Pilar Fossas Felip, Nicolás Morón, Sandra Bacca, Mauricio Molina, Francesc Casarramona, Lorena Elias, Muhammad Zidane Bukaei, Jose Antonio Martos Gutierrez, Judith Lopez Escuin, Cristina Olaizola, Yolexis López Vargas, Juan Jiménez Oyonarte, Rashida Soultana, Eduardo Sanjurjo Golpe, Esther Salvador, Guillem Vila, Marcos Serrano, Matilde Nuria López Claverol, Marian Lamolla, Miquel Amate, Adriana Rodriguez, Ruth Romero, Montgomery del Carpio, Ana Isabel Hernandez, Julián Martín, M Carmen Rosas, Antonio Nogueroles, Sorilandy Encarnación, Augusto Robles, Jose Antonio Herrera, Roger Gavilán, Toghrol Mameghani, Gastón Araujo, M.Angeles Garrido Morales, Enric Ramon Albert Segui, Eva Fernandez Climent, Francesc Paris Pujol, Mireia Judit Garrofé Seira, Lucía Gómez Pía, Fernando Salleres Nuñez, Cristina Aguar Peñalver, Cristina Vaz Lopes, Elisenda Ribera Tasa, Carmen Repullo Vilchez, Modesto Sánchez Zambrana, Beatriu Suescun Ribas, Inés Vilà Panés, Montserrat Vila Planavila, Alicia Vaqueiro Lorenzo, Meritxell Sabartés Guixes, Jorge Medina, David Sambrano, Javi Zamarreño, Carmen Pirela, Paola Vélez, Luis Cajamarca, Honey Pérez, Yarles Martínez, Jesus Alexander Gonçalves, Carles Regordosa, Claudia Mormeneo, Laura Griu, Maria Francia Colina, Enric Farik, Dolors Carrión Duch, Carles Badenas, Oscar Bernal, Núria Agramunt, Shyrlei Morales, Victoria Reynoso, Miguel Guerrero, Primitivo Romera Cid, Mònica Folqué, Claudia Pedroza, Adnan Hachem, Íñigo Soteras Martínez, Xavier Verdera García, Mercè López Amorós, Xavier Costa Subirós, Marta Cufí Benet, Cecile Van Eendenburg, Teresa Osuna, Dra Gina Santos, Mireia Pallisera, Lluís Gonzalo Oliva, Gemma Sanchez, Xavier Basurto, Ludgi Vivoda, Richard Van der Kleyn, Laura Robles, Ana Cabanelas Barranco, Mª Cruz Almendros, Marc Pérez Oliveras, Amelia Fernández Álvarez, Maria Rybyeva, Antoni Viñas, Maria Barcons, Joaquim Danès Alberto Tavera, Pablo Burbano, Cintie López, David Cruz, Paula Bisbe, Nora Fernández, Juan Carlos Palacio, Eduardo Fraiz, Oriol Aguiló, Rollmy Amorodjo, John Velázquez, Elena Sánchez, Jaume Español, Judit Perez de Celis, Anna Coll, Glòria Díaz, Margarida Vergés i Sala, Mª Ángels Casas Capdevila, Yosmairy Yoselin Ferrini, Aitor Gorriz, Diego-Javier Cucurell Navarro, Dulce Velásquez, Jaume Pla Soler, Josep González, Julian David Higuera, Lina Cuellar, Liza Margarita Miniello, Lluis Pujol, Sorin Cracan, Mora Vives, M Angela, Lopez Lopez, null Anabel, Montse Gorchs Molist, Delofeu Anna, Silvia Solà Muñoz, Ferreres Yolanda, Carol Pujalte, Elisabeth Téllez Marín, Yolanda Font Casas, Sara Hernández Luque, Joaquim Mejias Sendra, Francesca Mellado Valero, Campos Escala, Galup De Lacanal, Lopez Diaz, Castillo Paramio, Català Estopà, Español Moreda, Calafell Majo, Carballo Almeida, Castro Naval, M Elena, Cregut Ruiz, Pere Lluis, Deulofeu Font, Fabregat Sanjuan, Joan Pere, Fontquerni Gorchs, Forés Bellés, Joan Antoni, Gomez Herrera, Juan Carlos, Hijazo Prades, Itzaina Torvisco, Marti Rovira, Obiols Gonzalez, Olive Cavero, Querol Gil, M Soledad, Rico Rodriguez, Rios Sambernardo, Ropero Molina, Jose Ramon, Sanchez Valero, Santos Arevalo, Maria Jose, Soto Garcia, Maria Angeles, Tebar Escribano, Torres Garcia, Pedro José, Verdes Carrion, M Isabel, Verge Lopez, Juan Jose, Lopez Canela, M Angeles, Lucas Guarque, Morales Alvarez, Jorge Arnulfo, Morell Fornieles, Subirats Gomez, Maria Teresa, Torello Masa, Val Lopez, Maria Mercedes, Palmero Reyes, Juan Manuel, Rodriguez Forne, Ruana Turiel, Sanchez Gonzalez, Sebastia Gornals, Abrio Rico, Albert Gual Falip, Aznar Oliveros, Brugues Perotti, Calvet Molinero, Catells Franco, Corrales Medina, Daroca Miro, Duran Marquez, Feliu Pradas, Figueras Casanova, Garcia Tortajada, Grajera Gallego, Azahara del Mar, Las Arroyo, Dulcenombre de Jesus, Laserreta Sanz, Llambrich Vidal, Monllao Corral, Morales de la Cruz, Moreno Blanco, Orejuela Orgaz, Piñana Suazo, Pons Minguillon, Rodríguez Gómez, José Carlos, Rodriguez Pereira, Sedo Porcel, Sevil Villar, Sierra Lopez, Torres Romero, Trepat Calveres, Ventura Arnella, Acera Gil, M Teresa, Biesot Vico, Castro Galea, Rosa Maria, Escorcia Chafer, Juan Antonio, Gil Faure, Hernandez Luque, Jimenez Delgado, Mallafre Gay, M. Angel, Olivares Sanzo, Pubill Fondevila, Sabate Fort, Segovia Agámez, Antonio Carlos, Turata Longaretti, Valle Hernandez, Trayner Guixens, Aguilar Valor, Aguirre Alvarez, Alastrue Naval, Alferez Baquero, Alonso Marne, Cristina, Aloy Orozco, Alvarez Colino, Alvarez Peñuela, Ameller Cirilo, Maria Vanessa, Andujar Guerrero, Estefania Remedios, Auladell Sillero, Azcarate Sorbet, Basany Genesca, Benavent Barduena, Benito Tudela, Blanch Pardo, Boluda Pla, Bonilla Gonzalez, Bru Serramalera, Burnat Andreu, Caballero Calvo-Rayo, Calvo Casellas, Camps Mombiela, Cano Bresme, Carcelen Fernandez, Caro Solà, Casasas Matavacas, Castanedo Bolado, Cerdeña Cortina, Abella Jane, Laia Collado Borrego, Colom Orri, Comellas Vilanova, Conillera Sole, Cots Torres, Cuchi Estepa, de Sostoa Graell, del Rio Lopez, Delgado Compte, Diaz Bueno, Diaz Maneiro, Andrea Lucia, Domenech Palau, M. Carme, Duran Carasso, Pablo Javier, El Abidi, Escoda Martin, Esteve Casanovas, Fernandez Perez, Ferre Quintero, Flores Escobar, Fontcuberta Abad, Fortes del Valle, Mª Luisa, Franco Quesada, Sara Maria, Franco Romero, Gallego Francisco, Gamiz Gala, Alicia, Garcia Castañeda, Garcia Rodriguez, Casajuana Gemma, Gomez Arroyo, Gomez Girbau, Gonzalez Fernandez, Gonzalez Gonzalez, Gonzalez Lopez, Gual Obeso, Guerrero Blanco, Guillemas Roca, Guillermo Eudaldo, Hernandez Sebastia, Homar Covas, Hostench Alvarez, Huerta Royo, Ibañez Barcelo, Izquiero Cruz, Jaione Urdangarin Etxetxikia, Juárez Gimenez, Khlifi Alami, Laparra Gasco, Lara Moreales, Lasaosa Medina, Maria Lourdes, Lazaro Cava, Leon Berrar, López Maturana, Lopez Ramirez, López Romero, Lorente Marco, Lorenzo Martin, Lozano Casals, Lujan Nicola, Madrid Diaz, Jose Antonio, Maria Teresa Peris Morales, Marti Clemente, Martinez Castaño, David Natanael, Martinez Gamez, Martinez Gonzalez, Martinez Quesada, Maria de la Cabeza, Marzà Fusté, Mireia, M Conillera, Melendo Lasheras, Miralles Mestre, Montserrat Puig Pastalle, Montserrate Vidal, Mora Mellado, Morales Ponce, Morera Cabre, Morera Vivet, Mundi Souza, Muñoz Quiles, Navea Rosa, Neira Iglesias, M Asuncion, Nuñez Manrique, Mª Pilar, Obiols Martinez, Pallares Reig, Partegas Torres, Pascual Berengueras, Perez Gamez, Perez Oset, Perez Restrepo, Maria Alejandra, Planas Yeste, Planells Mangado, Puertas Carbonell, Quinteiro Blanco, Rebollar Benavente, Recasens Fernandez, Reyes Gomez, Maria del Carmen, Roca Pou, Rodriguez Ferrer, Rodriguez Franco, Rodriguez Fuertes, Rodriguez Muñoz, Rodriguez Navarro, Roig Iniesta, Romero Gracia, Rovira Brunet, Rovira de Eugenio, Rubio Baena, Ruiz Llorens, Sala Llamazares, San Juan Alaez, Sanchez Segura, Santasusana Soldevilla, Sanz Salmeron, Segura Perez, Serra Balcells, Sorina Dumitras, Teixidor Montoya, Tena Vicente, Tierno Salinas, Ester Ines, Toledo Testa, Tomàs Figueras, Tomas Ruperez, Torrano Garcia-Penche, Torres Esparza, Florenc Uku, Vazquez Blanco, Vazquez De la Paz, Vazquez Gil, Vazquez Gonzalez, Vidal Meler, Vilalta Cots, Vilches Jimenez, Visser Fernandez, Viu Gavin, Vives Vives, Carmona Jimenez, Francisco Jose, Galobardes Vilches, Gonzalez Gomez, Jodar Manzanera, Marimon Cortes, Marrodan Orive, Martin Bosch, Martorell Lopez, Millares Roca, M Jesus, Miralles Guri, Muliterno Hernandez, Muñoz Oliva, Pons Pujol, Postius Conde, Prieto Arruñada, Quintana Mathé, Rosell Mata, Alvarin Alvarez, Arrufat Flores, Bañuelos Pago, Campo Vilar, Cardus Hidalgo, Castello Gil, Maria Gloria, Castrillo Montsesinos, Clave Garces, Comes Sanroma, Descalzo Sequi, Errando Ricol, Escudero Campillo, Maria del Mar, Fernandez Alvarez, Fernandez Gomez, Franch Espinosa, Freixes Graells, Garcia Plaza, Garcia-Marron Gallego, Hernandez Simancas, Jaraba Armas, Jimenez Ramos, Lopez Oganissian, Madrona Romero, M Rosa, Martinez Millan, Martínez Morón, Merchan Encinas, Moreno Jimenez, Muñoz Rico, Navarro Rodriguez, Nogales Ibañez, Rita Maria, Novillo Viera, Parella Torrabadella, Mari Alba, Pera Villar, Carla Montserrat, Rabella Miralles, Ramis Trilles, Ribera Ortiz, Sastre Perez, Soro Borrega, Tapia Fores, Tellez Bernad, Trenado Alvarez, Felix Martin, Herrero Perez, Lanau Fuster, Lopez Gomariz, Pardo Lozano, Quintana Altimiras, Ventosa Lopez, Almodovar Damian, Alvarez Monterroso, Arambudo Comas, Boullon Garzon, Burgos Capella, Campuzano Garcia, Maria Del Mar, Capdevila Olivas, Carre Marti, Clara Isabel, Carretero Bacaicoa, Cazorla Calderon, Chacon Osuna, Cortes Planas, Cortit Olio, Delhomme Estany, Fructuos Martinez, Garcia Lopez, Pascual Luis, Genis Amill Vallve, Gonzalez Muñoz, Hernaez Ventura, Lavernia Gimenez, Martin Rojo, Martínez Medina, Mayol Barrera, Mercader Pi, Merino Dalmau, Miguel Campodarbe, Moreno Sanchez, Francisco Javier, Alba Mari, Penela Barrameda, Prieto Ajenjo, Rodriguez Pareja, Rodríguez Piñar, Javier Francisco, Rodriguez Tello, Romero Pereda, Sainz Saborido, Santacana Martin, Santos Martinez, Sierra Chavez, Turbau Torres, Vicente Domenech, Villena Esteo, Vives Pertegaz, Baena Gonzalez, Bagaria Pont, Beltran Sanchez, Bonet Alarcon, Borch Ballescà, Buhils Clanchet, Closa Garcia, Colomina Carril, Cristina Fernandez Sanchez, Fernandez Toledo Edurne Judith, Espases Rodriguez, Espert Resa, F Xavier, Fernández Sol, Gonzalez Lugo, Gracia Llesera, Herrada Lendinez, Juliench Liesa, Sandra Alicia, Lopez Ortega, Lopez Yuste, Lozano Villanueva, Lucia Sola Soto, Madrid Castellano, Megias Cano, Daniel Jesus, Montasell Ponce, Montesinos Sospedra, Moya Martinez, Muñoz Herrera, Ocaña Fernandez, Palau Bernal, Perez Sole, Ramon Carbonell, Ribas Lop, Rubio López, Rueda Lopez, Sabat Castaño, Sabata Lara, Salmerón Ramírez, Serra Creus, Serrano Dalmau, Sumasi Mainero, Gonzalo Gabriel, Valencia Primo, Ana Maria Viñuales Muñoz, Josep Roig, and Verònica Hidalgo.

Subjects
Stroke, Advanced and Specialized Nursing, Treatment Outcome, Endovascular Procedures, Humans, Neurology (clinical), Cardiology and Cardiovascular Medicine, Brain Ischemia, Ischemic Stroke, Thrombectomy, Workflow
Abstract

Background: We aim to compare the outcome of patients from urban areas, where the referral center is able to perform thrombectomy, with patients from nonurban areas enrolled in the RACECAT trial (Direct Transfer to an Endovascular Center Compared to Transfer to the Closest Stroke Center in Acute Stroke Patients With Suspected Large Vessel Occlusion). Methods: Patients with suspected large vessel occlusion stroke, as evaluated by a Rapid Arterial Occlusion Evaluation score of ≥5, from urban catchment areas of thrombectomy-capable centers during RACECAT trial enrollment period were included in the Stroke Code Registry of Catalonia. Primary outcome was disability at 90 days, as assessed by the shift analysis on the modified Rankin Scale score, in patients with an ischemic stroke. Secondary outcomes included mortality at 90 days, rate of thrombolysis and thrombectomy, time from onset to thrombolysis, and thrombectomy initiation. Propensity score matching was used to assemble a cohort of patients with similar characteristics. Results: The analysis included 1369 patients from nonurban areas and 2502 patients from urban areas. We matched 920 patients with an ischemic stroke from urban areas and nonurban areas based on their propensity scores. Patients with ischemic stroke from nonurban areas had higher degrees of disability at 90 days (median [interquartle range] modified Rankin Scale score, 3 [2–5] versus 3 [1–5], common odds ratio, 1.25 [95% CI, 1.06–1.48]); the observed average effect was only significant in patients with large vessel stroke (common odds ratio, 1.36 [95% CI, 1.08–1.65]). Mortality rate was similar between groups(odds ratio, 1.02 [95% CI, 0.81–1.28]). Patients from nonurban areas had higher odds of receiving thrombolysis (odds ratio, 1.36 [95% CI, 1.16–1.67]), lower odds of receiving thrombectomy(odds ratio, 0.61 [95% CI, 0.51–0.75]), and longer time from stroke onset to thrombolysis (mean difference 38 minutes [95% CI, 25–52]) and thrombectomy(mean difference 66 minutes [95% CI, 37–95]). Conclusions: In Catalonia, Spain, patients with large vessel occlusion stroke triaged in nonurban areas had worse neurological outcomes than patients from urban areas, where the referral center was able to perform thrombectomy. Interventions aimed at improving organizational practices and the development of thrombectomy capabilities in centers located in remote areas should be pursued. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02795962.

Published
2022
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33. Back home full in oxygen after Antalya: A report of the European Airway Conference 2023

Author

M. Sorbello, K.T. Saracoglu, G. Cortese, Xavier Onrubia, Ana Isabel Pereira, Özgur Canbay, Ayten Saracoglu, Pavel Michalek, Pedro Charco Mora, Arnd Timmermann, Greif Robert, and Sorbello M., Saracoglu K., Cortese G., Onrubia X., Pereira A. I. , CANBAY Ö., SARAÇOĞLU A., Michalek P., Mora P. C. , Timmermann A., et al.

Subjects
Internal Diseases, Internal Medicine Sciences, Klinik Tıp, Anesteziyoloji ve Ağrı Tıbbı, Yoğun Bakım Tıbbı, Intensive Care, ANESTEZİYOLOJİ, Dahili Tıp Bilimleri, CLINICAL MEDICINE, Yoğun Bakım, Sağlık Bilimleri, Critical Care and Intensive Care Medicine, İç Hastalıkları, Clinical Medicine (MED), Tıp, Anesthesiology and Pain Medicine, Anesteziyoloji, YOĞUN BAKIM, Anesthesiology, Surgery Medicine Sciences, Cerrahi Tıp Bilimleri, Health Sciences, Medicine, Klinik Tıp (MED), CRITICAL CARE MEDICINE
Published
2022
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34. First steps to study the demography of vascular epiphytes in cities

Author

D. Mondragón and M. P. Mora-Flores

Subjects
General Agricultural and Biological Sciences
Abstract

Urban ecosystems could jeopardize the existence of vascular epiphytes (VE) given that their occurrence is linked to phorophyte availability and particular climatic conditions. Despite reports of VE in cities, nothing is known about their demography. A first step in this direction is to describe their population structures (PS). We established the PS of VE present in urban parks in Oaxaca City (Mexico), addressing the following questions: 1) what is their demographic status? and 2) are there differences in the structure of populations growing in native versus exotic phorophytes? During 2021, we censused all the trees in six urban parks, recording their origin (native or exotic), the epiphytic species found on them and the development stages present in each VE population. Overall, five VE species were documented: Tillandsia ionantha, T. makoyana, T. sp., T. schiedeana and T. recurvata (Bromeliaceae); the first three with only one individual and the latter two with 95 and 5,694, respectively. A MANOVA test indicated significant differences in PS between T. recurvata (type I structure, suggesting a growing population) and T. schiedeana (type III structure, suggesting a senile population) (Wilkes' λ= 0.821, F-Radio= 11.96 P

Published
2024
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35. Contributors

Author

Ali M. Agha, Lydia C. Alexander, Christie M. Ballantyne, Harold Bays, Deepak L. Bhatt, Roger S. Blumenthal, Michael B. Boffa, Rachel M. Bond, Julia M. Brandts, Eliot A. Brinton, Julie A. Brothers, Alberico L. Catapano, Dick C. Chan, Laura Chiavaroli, Laura Browning Cho, Leslie Cho, Danielle Cummings, Stephen R. Daniels, Matthew R. Deshotels, Erik Dove, David I. Feldman, Bengt Fellström, Keith C. Ferdinand, Carl J. Fichtenbaum, Angela Fitch, Daniel Gaudet, Henry N. Ginsberg, Ty J. Gluckman, Robert A. Hegele, Ron C. Hoogeveen, Aliza Hussain, Alan G. Jardine, David J.A. Jenkins, Peter H. Jones, Peter Jones, Sergey M. Kachur, Cyril W.C. Kendall, Joshua W. Knowles, Jon A. Kobashigawa, Marlys L. Koschinsky, Penny M. Kris-Etherton, Carl J. Lavie, Peter Libby, Santica M. Marcovina, Patrick B. Mark, Nicholas A. Marston, Seth Shay Martin, Erin D. Michos, Arash Mirrahimi, Samia Mora, Patrick M. Moriarty, Vijay Nambi, Adam J. Nelson, Stephen J. Nicholls, Steven E. Nissen, Børge Grønne Nordestgaard, Giuseppe Danilo Norata, Carl Orringer, Brian T. Palmisano, Darshna Patel, Rajan K. Patel, Vishnu Priya Pulipati, Frederick J. Raal, Daniel J. Rader, Kausik K. Ray, Chesney Richter, Paul M. Ridker, Marc S. Sabatine, Maya S. Safarova, Raul D. Santos, Joseph J. Saseen, Gregory G. Schwartz, Rachel J. Shustak, John L. Sievenpiper, Nickpreet Singh, Ann C. Skulas-Ray, Kristie Srichaikul, Neil J. Stone, Lale Tokgözoğlu, Anne Tybjærg-Hansen, Salim S. Virani, Karol Watson, Gerald F. Watts, Nanette K. Wenger, and Julia M.W. Wong

Published
2024
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39. Colombia: avances y desafíos frente a la delincuencia organizada transnacional

Author

Sergio Stany Maldonado-Morales, Francisco Hersan González-Chavarro, Cristian David Ibáñez-Cano, Fabian Camilo Vargas-González, Edwin Andrés Rondón-Narváez, Cesar Enrique Ramos-Hinestrosa, Sandra Patricia Naizaque-Borda, Davinson Argemiro Mora-Carreño, and Mauro Andrés Martínez-Castillo

Abstract

A partir de la importancia que ha tomado la Delincuencia Organizada Transnacional actualmente, que se favorece por el proceso de globalización internacional, este libro busca abordar aquellas amenazas que en el marco de la seguridad multidimensional se categorizan en esta tipología criminal. En este sentido, el objetivo de esta investigación es analizar la incidencia de la Delincuencia Organizada Transnacional, tanto en la región como en Colombia. Esta investigación es un avance en la exploración de las amenazas a la seguridad que enfrentan las fronteras colombianas y trata temas de la coyuntura nacional e internacional, esperándose que sea un insumo de futuras investigaciones y proyecciones estatales en el abordaje de las amenazas de la Delincuencia Organizada Transnacional.

Published
2023
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41. On the dimension and structure of the square of the dual of a Goppa code

Author

Rocco Mora, Jean-Pierre Tillich, Sorbonne Université (SU), Cryptologie symétrique, cryptologie fondée sur les codes et information quantique (COSMIQ), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), ANR-17-CE39-0007,CBCRYPT,Cryptographie basée sur les codes(2017), ANR-21-CE39-0009,BARRACUDA,Algèbre, preuves, protocoles, algorithmes, courbes, et surfaces pour les codes et leurs applications(2021), Mora, Rocco, Cryptographie basée sur les codes - - CBCRYPT2017 - ANR-17-CE39-0007 - AAPG2017 - VALID, and Algèbre, preuves, protocoles, algorithmes, courbes, et surfaces pour les codes et leurs applications - - BARRACUDA2021 - ANR-21-CE39-0009 - AAPG2021 - VALID

Subjects
FOS: Computer and information sciences, Computer Science - Cryptography and Security, Information Theory (cs.IT), Computer Science - Information Theory, Algebraic codes, Applied Mathematics, Distinguisher of Goppa codes, Computer Science Applications, [INFO.INFO-CR]Computer Science [cs]/Cryptography and Security [cs.CR], [INFO.INFO-IT]Computer Science [cs]/Information Theory [cs.IT], Square codes, Goppa codes, [INFO.INFO-IT] Computer Science [cs]/Information Theory [cs.IT], Alternant codes, Code-based Cryptography, Cryptography and Security (cs.CR), Computer Science::Information Theory, Computer Science::Cryptography and Security, [INFO.INFO-CR] Computer Science [cs]/Cryptography and Security [cs.CR]
Abstract

International audience; The Goppa Code Distinguishing (GD) problem asks to distinguish efficiently a generator matrix of a Goppa code from a randomly drawn one. We revisit a distinguisher for alternant and Goppa codes through a new approach, namely by studying the dimension of square codes. We provide here a rigorous upper bound for the dimension of the square of the dual of an alternant or Goppa code, while the previous approach only provided algebraic explanations based on heuristics. Moreover, for Goppa codes, our proof extends to the non-binary case as well, thus providing an algebraic explanation for the distinguisher which was missing up to now. All the upper bounds are tight and match experimental evidence. Our work also introduces new algebraic results about products of trace codes in general and of dual of alternant and Goppa codes in particular, clarifying their square code structure. This might be of interest for cryptanalysis purposes.

Published
2022
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42. Conceptual and Analytical Diversity of Environmental Governance in Latin America: A Systematic Review

Author

GABRIELA DE LA MORA-DE LA MORA

Subjects
Global and Planetary Change, Ecology, Pollution
Abstract

The analysis of environmental governance and the analytical frameworks used to study this concept in Latin America show that the term is diffuse and polysemic. The term governance refers to democratic societies that theoretically encourage the plural participation of actors in decision-making to solve public or collective socioenvironmental problems. However, in Latin America, there is a broad social perception of a democratic deficit that affects the socioenvironmental sphere. The objective of this work is to determine the main trends in studies on environmental governance in Latin America, the most commonly used analytical frameworks and the predominant approaches in order to characterize the scientific and political uses of the concept. A systematic literature review is carried out on databases in English and Spanish, and 140 articles that consider environmental governance using various analytical frameworks are analyzed. The main finding is the predominance of a critical perspective on the effectiveness of environmental governance, as well as the associated institutional components and social organizations, because the democratic practices that should support it are questionable.

Published
2022
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43. Changes in perinatal management and outcomes in infants born at 23 weeks of gestational age during the last decade in Spain

Author

Roser Porta, Paula Sol Ventura, Gemma Ginovart, Fermín García-Muñoz, Alejandro Ávila-Alvarez, Montserrat Izquierdo, Josep Figueras, Alberto Pérez, Ramon Aguilera, Ana María Campos, Sandra Terroba, Tomás Sánchez-Tamayo, M. Dolores Elorza, Araceli Corredera, Belén Fernández, Pilar Adelaida Crespo, M. Isabel De Las Cuevas, Miguel Ángel Cortajarena, Carmen Macias, Pedro Fuster, Segundo Rite, M. Purificación Ventura, M. Isabel Izquierdo, Ana Belén Escobar, M. Luz Couce, Elena Pilar Gutierrez, Dorotea. Blanco, M. Yolanda Ruiz, Lourdes Urquía, Rafael Garcia, M. Pilar Jaraba, Cristina De Frutos, Sílvia Martínez-Nadal, Martin Iriondo, Amaya Rodriguez, María Gonzalez, Maria Fernanda Moreno, Joan Badia, M. Mar Montejo, Aintzane Euba, Mar Albújar, Irene Cuadrado, Paula Serrano, Andres Martinez, Elisenda Moliner, Elena María Márquez, Maria Arroyas, María Suárez, Víctor Manuel Marugán, María Victoria Ramos, Gerardo Romera, Carolina Vizcaíno, David Mora, Laura Acosta, Eduard Soler, Mercedes Granero, Javier Estañ, Miguel Angel García, Luísa López, Alberto Trujillo, Israel Anquela, Almudena Alonso, Carmen Rosa Pallás, Sabina Romero, Carmen González, Jose María Lloreda, Laura Domingo, Laura Castells, Concepción Goñi, M. Dolores Muro, Elena García, Teresa Prada, Isabel Llana, Manuela López, María González, Manuel Baca, Paula Martín-Mora, Alicia Sardina, Emilia María Martínez, David Lozano, Lorena Patricia Peña, Ana Filgueira, and Ana Martinez

Subjects
Pediatrics, Perinatology and Child Health, Obstetrics and Gynecology
Abstract

The 2021-updated guidelines of the Spanish Society of Neonatology Guidelines have moved the zone of parental discretion to 23 + 0-23 + 6 weeks. The objective of this study was to describe the changes in perinatal management at this gestational age along the last decade and to determine if a more active perinatal management has contributed to improved outcomes.Retrospective analysis of prospectively collected data from the 23-week infants included in the Spanish SEN 1500 neonatal network during the period 2010-2019. The main study outcomes were survival at discharge and survival without major morbidity of actively managed infants. Two periods were compared: 2010-2014 (Period 1) and 2015-2019 (Period 2). NICUs were classified into low activity NICUs (less than 50 admissions of very low birth weight infants per year) and high activity NICUs (50 or more admissions).A total of 381 infants were included, 182 in Period 1 and 199 in Period 2. In Period 2 an increase in the use of intrapartum magnesium sulfate (21.5% vs 39.9%,A change to a more active intention to treat infants born at 23 weeks is taking place in Spain. But the survival rate of the actively-managed infants has remained stable around 25-30% during the study period. A multidisciplinary effort is needed to improve outcomes in this population.

Published
2022
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44. Follow‐up of intraocular retinoblastoma through the quantitative analysis of conserved nuclear <scp>DNA</scp> sequences in aqueous humor from patients

Author

Maria Cuadrado‐Vilanova, Victor Burgueño, Leire Balaguer‐Lluna, Rosario Aschero, Helena Castillo‐Ecija, Jing Liu, Sara Perez‐Jaume, Guillem Pascual‐Pasto, Nagore G Olaciregui, Soledad Gomez‐Gonzalez, Genoveva Correa, Mariona Suñol, Paula Schaiquevich, François Radvanyi, Cinzia Lavarino, Jaume Mora, Jaume Catala‐Mora, Guillermo L Chantada, and Angel M Carcaboso

Subjects
Pathology and Forensic Medicine
Abstract

Fundoscopy is the standard method for diagnosis and follow-up of intraocular retinoblastoma, but it is sometimes insufficient to discern whether tumors are inactivated following treatments. In this work, we hypothesized that the amount of conserved nuclear DNA sequences in the cell-free DNA (cfDNA) fraction of the aqueous humor (AH) might complement fundoscopy for retinoblastoma follow-up. To address our hypothesis, we developed highly sensitive droplet digital polymerase chain reaction (ddPCR) methods to quantify highly conserved DNA sequences of nucleus-encoded genes (GAPDH and B4GALNT1) and of a mitochondrial gene, MT-ATP6. We obtained AH samples during intravitreal treatments. We analyzed 42 AH samples from 25 patients with intraocular retinoblastoma and 11 AH from controls (non-cancer patients). According to clinical criteria, we grouped patients as having progression-free or progressive retinoblastoma. cfDNA concentration in the AH was similar in both retinoblastoma groups. Copy counts for nucleus-derived sequences of GAPDH and B4GALNT1 were significantly higher in the AH from patients with progressive disease, compared to the AH from progression-free patients and control non-cancer patients. The presence of mitochondrial DNA in the AH explained that both retinoblastoma groups had similar cfDNA concentration in AH. The optimal cut-off point for discriminating between progressive and progression-free retinoblastomas was 108 GAPDH copies per reaction. Among patients having serial AH samples analyzed during their intravitreal chemotherapy, GAPDH copies were high and decreased below the cut-off point in those patients responding to chemotherapy. In contrast, one non-responder patient remained with values above the cut-off during follow-up, until enucleation. We conclude that the measurement of conserved nuclear gene sequences in AH allows follow-up of intraocular retinoblastoma during intravitreal treatment. The method is applicable to all patients and could be relevant for those in which fundoscopy evaluation is inconclusive.

Published
2022
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45. Poor timing and failure of source control are risk factors for mortality in critically ill patients with secondary peritonitis

Author

De Pascale, Gennaro, Antonelli, Massimo, Deschepper, Mieke, Arvaniti, Kostoula, Blot, Koen, Brown, Ben Creagh, de Lange, Dylan, De Waele, Jan, Dikmen, Yalim, Dimopoulos, George, Eckmann, Christian, Francois, Guy, Girardis, Massimo, Koulenti, Despoina, Labeau, Sonia, Lipman, Jeffrey, Lipovetsky, Fernando, Maseda, Emilio, Montravers, Philippe, Mikstacki, Adam, Paiva, José-Artur, Pereyra, Cecilia, Rello, Jordi, Timsit, Jean-Francois, Vogelaers, Dirk, Blot, Stijn, Lamrous, Amin, Lipovestky, Fernando, Rezende-Neto, Joao, Vymazal, Tomas, Fjeldsoee-Nielsen, Hans, Kott, Matthias, Kostoula, Arvaniti, Javeri, Yash, Einav, Sharon, Makikado, Luis Daniel Umezawa, Tomescu, Dana, Gritsan, Alexey, Jovanovic, Bojan, Venkatesan, Kumaresh, Mirkovic, Tomislav, Creagh-Brown, Benedict, Emmerich, Monica, Canale, Mariana, Dietz, Lorena Silvina, Ilutovich, Santiago, Miñope, John Thomas Sanchez, Silva, Ramona Baldomera, Montenegro, Martin Alexis, Martin, Patricio, Saul, Pablo, Chediack, Viviana, Sutton, Giselle, Couce, Rocio, Balasini, Carina, Gonzalez, Susana, Lascar, Florencia Maria, Descotte, Emiliano Jorge, Gumiela, Natalia Soledad, Pino, Carina Alejandra, Cesio, Cristian, Valgolio, Emanuel, Cunto, Eleonora, Dominguez, Cecilia, Nelson, Nydia Funes, Abegao, Esteban Martin, Pozo, Norberto Christian, Bianchi, Luciana, Correger, Enrique, Pastorino, Maria Laura, Miyazaki, Erica Aurora, Grubissich, Nicolas, Garcia, Mariel, Bonetto, Natalia, Quevedo, Noelia Elizabeth, Gomez, Cristina Delia, Queti, Felipe, Estevarena, Luis Gonzalez, Fernandez, Ruben, Santolaya, Ignacio, Grangeat, Sergio Hugo, Doglia, Juan, Zakalik, Graciela, Pellegrini, Carlos, Lloria, Maria Monserrat, Chacon, Mercedes Esteban, Fumale, Mariela, Leguizamon, Mariela, Hidalgo, Irene Beatriz, Tiranti, Roberto Juli an, Capponi, Paola, Tita, Agustin, Cardonnet, Luis, Bettini, Lisandro, Ramos, Agñel, Lovesio, Luciano, Miranda, Edith Miriam, Farfan, Angelica Beatriz, Tolosa, Carina, Segura, Lise, Bellocchio, Adelina, Alvarez, Brian, Manzur, Adriana, Lujan, Rodolfo, Fernandez, Natalia, Scarone, Nahuel, Zazu, Alan, Groh, Carina, Fletcher, Jason, Smith, Julie, Azad, Raman, Chavan, Nitin, Kol, Mark, Campbell, Lewis, Starr, Therese, Roberts, Brigit, Wibrow, Bradley, Warhurst, Timothy, Chinthamuneedi, Meher, Ferney, Bernal Buitrago, Simon, Marc, De Backer, Daniel, Wittebole, Xavier, De Bels, David, Collin, Vincent, Dams, Karolien, Jorens, Philippe, Dubois, Jasperina, Gunst, Jan, Haentjens, Lionel, De Schryver, Nicolas, Dugernier, Thierry, Rizoli, Sandro, Santillan, Paul, Han, Yi, Biskup, Ewelina, Qu, Changjing, Li, Xinyu, Yu, Tao, Weihua, Lu, Molano-Franco, Daniel, Rojas, José, Oviedo, Juan Mauricio Pardo, Pinilla, Dario, Cardenas, Yenny, Celis, Edgar, Arias, Mario, Vukovic, Anita, Vudrag, Maja, Belavic, Matija, Zunic, Josip, Kuharic, Janja, Kricka, Irena Bozanic, Filipovic-Grcic, Ina, Tomasevic, Boris, Obraz, Melanija, Bodulica, Bruna, Dohnal, Martin, Malaska, Jan, Kratochvil, Milan, Satinsky, Igor, Schwarz, Peter, Kos, Zdenek, Blahut, Ladislav, Maca, Jan, Protus, Marek, Kieslichová, Eva, Nielsen, Louise Gramstrup, Krogh, Birgitte Marianne, Rivadeneira, Francisco, Morales, Freddy, Mora, José, Orozco, Alexandra Saraguro, MorochoTutillo, Diego Rolando, Vargas, Nelson Remache, Yepez, Estuardo Salgado, Villamagua, Boris, Alsisi, Adel, Fahmy, Abdelraouf, Dupont, Hervé, Lasocki, Sigismond, Paugam-Burtz, Catherine, Foucrier, Arnaud, Nica, Alexandru, Barjon, Geneviève, Mallat, Jihad, Marcotte, Guillaume, Leone, Marc, Duclos, Gary, Burtin, Philippe, Atchade, Enora, Mahjoub, Yazine, Misset, Benoît, Timsit, Jean-François, Dupuis, Claire, Veber, Benoît, Debarre, Matthieu, Collange, Oliver, Pottecher, Julien, Hecketsweiler, Stephane, Fromentin, Mélanie, Tesnière, Antoine, Koch, Christian, Sander, Michael, Elke, Gunnar, Wrigge, Hermann, Simon, Philipp, Chalkiadaki, Anthoula, Tzanidakis, Charalampos, Pneumatikos, Ioannis, Sertaridou, Eleni, Mastora, Zafiria, Pantazopoulos, Ioannis, Papanikolaou, Metaxia, Papavasilopoulou, Theonymfi, Floros, John, Diakaki, Chryssa, Rallis, Michael, Paridou, Alexandra, Kalogeromitros, Alexandros, Romanou, Vasiliki, Nikolaou, Charikleia, Kounougeri, Katerina, Tsigou, Evdoxia, Psallida, Vasiliki, Karampela, Niki, Mandragos, Konstantinos, Kontoudaki, Eftychia, Pentheroudaki, Alexandra, Farazi-Chongouki, Christos, Karakosta, Agathi, Chouris, Isaac, Radu, Vasiliki, Malliotakis, Polychronis, Kokkini, Sofia, Charalambous, Eliana, Kyritsi, Aikaterini, Koulouras, Vasilios, Papathanakos, Georgios, Nagky, Eva, Lampiri, Clairi, Tsimpoukas, Fotios, Sarakatsanos, Ioannis, Georgakopoulos, Panagiotis, Ravani, Ifigeneia, Prekates, Athanasios, Sakellaridis, Konstantinos, Christopoulos, Christos, Vrettou, Efstratia, Stokkos, Konstantinos, Pentari, Anastasia, Marmanidou, Kyriaki, Kydona, Christina, Tsoumaropoulos, Georgios, Bitzani, Militisa, Kontou, Paschalina, Voudouris, Antonios, Flioni, Elli-Nikki, Antypa, Elli, Chasou, Eleftheria, Anisoglou, Souzana, Papageorgiou, Eirini, Paraforou, Theoniki, Tsioka, Agoritsa, Karathanou, Antigoni, Vakalos, Aristeidis, Shah, Bhagyesh, Thakkar, Chirag, Jain, Nikhilesh, Gurjar, Mohan, Baronia, Arvind, Sathe, Prachee, Kulkarni, Shilpa, Paul, Cherish, Paul, John, Masjedi, Mansoor, Nikandish, Reza, Zand, Farid, Sabetian, Golnar, Mahmoodpoor, Ata, Hashemian, Seyed Mohammadreza, Bala, Miklosh, Flocco, Romeo, Torrente, Sergio, Pota, Vincenzo, Spadaro, Savino, Volta, Carlo, Serafini, Giulia, Boraso, Sabrina, Tiberio, Ivo, Cortegiani, Andrea, Misseri, Giovanni, Barbagallo, Maria, Nicolotti, Davide, Forfori, Francesco, Corradi, Francesco, Pelagalli, Lorella, Brazzi, Luca, Vittone, Ferdinando Giorgio, Russo, Alessandro, Simion, Davide, Cotoia, Antonella, Toppin, Gilda Cinnella Patrick, Johnson-Jackson, Roxanne, Hayashi, Yoshiro, Yamamoto, Ryohei, Yasuda, Hideto, Kishihara, Yuki, Shiotsuka, Junji, Sanchez-Hurtado, Luis Alejandro, Tejeda-Huezo, Brigitte, Gorordo, Luis, Ñamendys-Silva, Silvio A, Garcia-Guillen, Francisco J, Martinez, Manuel, Romero-Meja, Erick, Colorado-Dominguez, Ever, van den Oever, Huub, Kalff, Karel Martijn, Vermeijden, Wytze, Cornet, Alexander Daniel, Beck, Oliver, Cimic, Nedim, Dormans, Tom, Bormans, Laura, Bakker, Jan, Van Duijn, Ditty, Bosman, Gerrit, Vos, Piet, Kesecioglu, Jozef, Haas, Lenneke, Henein, Akram, Miranda, Ariel M, Malca, Gonzalo Ernesto Gianella, Arroyo-Sanchez, Abel, Misiewska-Kaczur, Agnieszka, Akinyi, Frisch, Czuczwar, Miroslaw, Luczak, Karolina, Sulkowski, Wiktor, Tamowicz, Barbara, Swit, Beata, Baranowski, Bronisław, Smuszkiewicz, Piotr, Trojanowska, Iwona, Rzymski, Stanislaw, Sawinski, Mariusz, Trosiak, Marta, Mikaszewska-Sokolewicz, Malgorzata, Alves, Ricardo, Leal, Dina, Krystopchuk, Andriy, Mendonca, Pedro Muguel Hilario, Pereira, Rui Antunes, de Carvalho, Maria Raquel Lopes Marques, Candeias, Carlos, Molinos, Elena, Ferreira, Amélia, Castro, Guiomar, Pereira, José-Manuel, Santos, Lurdes, Ferreira, Alcina, Pascoalinho, Dulce, Ribeiro, Rosa, Domingos, Guilherme, Gomes, Pedro, Nora, David, Costa, Rui Pedro, Santos, Anabela, Alsheikhly, Ahmed Subhy, Popescu, Mihai, Grigoras, Ioana, Patrascanu, Emilia, Zabolotskikh, Igor, Musaeva, Tatiana, Gaigolnik, Denis, Kulabukhov, Vladimir, Belskiy, Vladislav, Zubareva, Nadezhda, Tribulev, Maxim, Abdelsalam, Ahmed, Aldarsani, Ayman, Al-Khalid, Muhammad, Almekhlafi, Ghaleb, Mandourah, Yasser, Doklestic, Krstina, Velickovic, Jelena, Velickovic, Dejan, Jankovic, Radmilo, Skoric-Jokic, Svetlana, Radovanovic, Dragana, Richards, Guy, Alli, Ahmad, Cordoba Nielfa, del Carmen, Iniesta, Rafael Sánchez, Martínez, Adela Benítez-Cano, Bernedo, Carlos Garcia, Gil, Santiago Alberto Picos, Nuvials, Xavier, Garcia, Joseba Gonzalez, Peña, Jose Manuel Garcia, Jimenez, Roberto, Herrera, Luis, Barrachina, Laura Galarza, Monzon, Ignacio Catalan, Redondo, Francisco Javier, Villazala, Ruben, Zapata, Diego Fernando Matallana, Lopez, Isabel Maria Villa, Moreno-Gonzalez, Gabriel, Lopez-Delgado, Juan Carlos, Marin, Jorge Solera, Sanchez-Zamora, Purificacion, Vidal, Montserrat Vallverdú, González, Jesús Flores, Salinas, Irene, Hermosa, Cecilia, Martinez-Sagasti, Fernando, Domingo-Marín, Sara, Victorino, Johanna Abril, Garcia-Alvarez, Raquel, Calleja, Pablo López-Arcas, de la Torre-Prados, Maria Victoria, Vidal-Cortes, Pablo, del Río-Carbajo, Lorena, Izura, Javier, Minguez, Victoria, Alvarez, Josep Trenado, Prous, Anna Parera, Paz, Daniel, Roche-Campo, Ferran, Aguilar, Gerardo, Belda, Javier, Rico-Feijoo, Jesus, Aldecoa, Cesat, Zalba-Etayo, Begoña, Dullenkopf, Alexander, Trongtrakul, Konlawij, Chtsomkasem, Anusang, Akbaş, Türkay, Unal, Mustafa Necmettin, Gumus, Ayca, Ramazanoglu, Atilla, Memis, Dilek, Mehmet, Inal, Urkmez, Seval, Ozgultekin, Asu, Demirkiran, Oktay, Aslan, Nesrin Ahu, Kizilaslan, Deniz, Kahveci, Ferda, Ünlü, Nurdan, Ozkan, Zeynep, Kaye, Callum, Jansen, Jan, O’Neill, Orla, Nutt, Christopher, Jha, Rajeev, Hooker, Nicolas, Grecu, Irina, Petridou, Christina, Shyamsundar, Murali, McNamee, Lia, Trinder, John, Hagan, Samantha, Kelly, Catriona, Silversides, Jonathon, Groba, Casiano Barrera, Boyd, Owen, Bhowmick, Kaushik, Humphreys, Sally, Summers, Charlotte, Polgarova, Petra, Margarson, Michael, Dickens, Justin, Pearson, Suzanne, Chinery, Elaine, Hemmings, Noel, O’Kane, Sinead, Austin, Pauline, Cole, Stephen, Plowright, Catherine, Box, Roberta, Wright, Christopher, Young, Lorna, Creagh-Brown, Ben, Montague, Laura, Parker, Robert, Morton, Ben, Ostermann, Marlies, Bilinska, Julia, Rose, Bernd Oliver, Reece-Anthony, Rosie, Ryan, Christine, Hamilton, Mark, Hopkins, Philip, Wendon, Julia, Brescia, Giovanni, Ijaz, Nazia, Wood, James, George, Michelle, Toth-Tarsoly, Piroska, Yates, Bryan, Armstrong, Maureen, Scott, Carmen, Boyd, Christine, Szakmany, Tamas, Rees, David, Pulak, Paul, Coggon, Mandy, Saha, Bhaskar, Kent, Linda, Gibson, Bethan, Camsooksai, Julie, Reschreiter, Henrik, Morgan, Pat, Sangaralingham, Sivatharshini, Lowe, Alastair, Vondras, Petr, Jamadarkhana, Sunil, Cruz, Carina, Bhandary, Rakesh, Hersey, Peter, Furneval, Julie, Innes, Richard, Doble, Patricia, Attwood, Ben, Parsons, Penny, Page, Valerie, Zhao, Xiaobei, Dalton, Julian, Hegazy, Mohammed, Awad, Yasser, Naylor, Douglas, Naylor, Amanda, Lee, Sarah, Brevard, Sidney, Davis, Noelle, De Pascale, Gennaro, Antonelli, Massimo, Deschepper, Mieke, Arvaniti, Kostoula, Blot, Koen, Brown, Ben Creagh, de Lange, Dylan, De Waele, Jan, Dikmen, Yalim, Dimopoulos, George, Eckmann, Christian, Francois, Guy, Girardis, Massimo, Koulenti, Despoina, Labeau, Sonia, Lipman, Jeffrey, Lipovetsky, Fernando, Maseda, Emilio, Montravers, Philippe, Mikstacki, Adam, Paiva, José-Artur, Pereyra, Cecilia, Rello, Jordi, Timsit, Jean-Francoi, Vogelaers, Dirk, Blot, Stijn, Lamrous, Amin, Lipovestky, Fernando, Rezende-Neto, Joao, Vymazal, Toma, Fjeldsoee-Nielsen, Han, Kott, Matthia, Kostoula, Arvaniti, Javeri, Yash, Einav, Sharon, Makikado, Luis Daniel Umezawa, Tomescu, Dana, Gritsan, Alexey, Jovanovic, Bojan, Venkatesan, Kumaresh, Mirkovic, Tomislav, Creagh-Brown, Benedict, Emmerich, Monica, Canale, Mariana, Dietz, Lorena Silvina, Ilutovich, Santiago, Miñope, John Thomas Sanchez, Silva, Ramona Baldomera, Montenegro, Martin Alexi, Martin, Patricio, Saul, Pablo, Chediack, Viviana, Sutton, Giselle, Couce, Rocio, Balasini, Carina, Gonzalez, Susana, Lascar, Florencia Maria, Descotte, Emiliano Jorge, Gumiela, Natalia Soledad, Pino, Carina Alejandra, Cesio, Cristian, Valgolio, Emanuel, Cunto, Eleonora, Dominguez, Cecilia, Nelson, Nydia Fune, Abegao, Esteban Martin, Pozo, Norberto Christian, Bianchi, Luciana, Correger, Enrique, Pastorino, Maria Laura, Miyazaki, Erica Aurora, Grubissich, Nicola, Garcia, Mariel, Bonetto, Natalia, Quevedo, Noelia Elizabeth, Gomez, Cristina Delia, Queti, Felipe, Estevarena, Luis Gonzalez, Fernandez, Ruben, Santolaya, Ignacio, Grangeat, Sergio Hugo, Doglia, Juan, Zakalik, Graciela, Pellegrini, Carlo, Lloria, Maria Monserrat, Chacon, Mercedes Esteban, Fumale, Mariela, Leguizamon, Mariela, Hidalgo, Irene Beatriz, Tiranti, Roberto Juli an, Capponi, Paola, Tita, Agustin, Cardonnet, Lui, Bettini, Lisandro, Ramos, Agñel, Lovesio, Luciano, Miranda, Edith Miriam, Farfan, Angelica Beatriz, Tolosa, Carina, Segura, Lise, Bellocchio, Adelina, Alvarez, Brian, Manzur, Adriana, Lujan, Rodolfo, Fernandez, Natalia, Scarone, Nahuel, Zazu, Alan, Groh, Carina, Fletcher, Jason, Smith, Julie, Azad, Raman, Chavan, Nitin, Kol, Mark, Campbell, Lewi, Starr, Therese, Roberts, Brigit, Wibrow, Bradley, Warhurst, Timothy, Chinthamuneedi, Meher, Ferney, Bernal Buitrago, Simon, Marc, De Backer, Daniel, Wittebole, Xavier, De Bels, David, Collin, Vincent, Dams, Karolien, Jorens, Philippe, Dubois, Jasperina, Gunst, Jan, Haentjens, Lionel, De Schryver, Nicola, Dugernier, Thierry, Rizoli, Sandro, Santillan, Paul, Han, Yi, Biskup, Ewelina, Qu, Changjing, Li, Xinyu, Yu, Tao, Weihua, Lu, Molano-Franco, Daniel, Rojas, José, Oviedo, Juan Mauricio Pardo, Pinilla, Dario, Cardenas, Yenny, Celis, Edgar, Arias, Mario, Vukovic, Anita, Vudrag, Maja, Belavic, Matija, Zunic, Josip, Kuharic, Janja, Kricka, Irena Bozanic, Filipovic-Grcic, Ina, Tomasevic, Bori, Obraz, Melanija, Bodulica, Bruna, Dohnal, Martin, Malaska, Jan, Kratochvil, Milan, Satinsky, Igor, Schwarz, Peter, Kos, Zdenek, Blahut, Ladislav, Maca, Jan, Protus, Marek, Kieslichová, Eva, Nielsen, Louise Gramstrup, Krogh, Birgitte Marianne, Rivadeneira, Francisco, Morales, Freddy, Mora, José, Orozco, Alexandra Saraguro, MorochoTutillo, Diego Rolando, Vargas, Nelson Remache, Yepez, Estuardo Salgado, Villamagua, Bori, Alsisi, Adel, Fahmy, Abdelraouf, Dupont, Hervé, Lasocki, Sigismond, Paugam-Burtz, Catherine, Foucrier, Arnaud, Nica, Alexandru, Barjon, Geneviève, Mallat, Jihad, Marcotte, Guillaume, Leone, Marc, Duclos, Gary, Burtin, Philippe, Atchade, Enora, Mahjoub, Yazine, Misset, Benoît, Timsit, Jean-Françoi, Dupuis, Claire, Veber, Benoît, Debarre, Matthieu, Collange, Oliver, Pottecher, Julien, Hecketsweiler, Stephane, Fromentin, Mélanie, Tesnière, Antoine, Koch, Christian, Sander, Michael, Elke, Gunnar, Wrigge, Hermann, Simon, Philipp, Chalkiadaki, Anthoula, Tzanidakis, Charalampo, Pneumatikos, Ioanni, Sertaridou, Eleni, Mastora, Zafiria, Pantazopoulos, Ioanni, Papanikolaou, Metaxia, Papavasilopoulou, Theonymfi, Floros, John, Diakaki, Chryssa, Rallis, Michael, Paridou, Alexandra, Kalogeromitros, Alexandro, Romanou, Vasiliki, Nikolaou, Charikleia, Kounougeri, Katerina, Tsigou, Evdoxia, Psallida, Vasiliki, Karampela, Niki, Mandragos, Konstantino, Kontoudaki, Eftychia, Pentheroudaki, Alexandra, Farazi-Chongouki, Christo, Karakosta, Agathi, Chouris, Isaac, Radu, Vasiliki, Malliotakis, Polychroni, Kokkini, Sofia, Charalambous, Eliana, Kyritsi, Aikaterini, Koulouras, Vasilio, Papathanakos, Georgio, Nagky, Eva, Lampiri, Clairi, Tsimpoukas, Fotio, Sarakatsanos, Ioanni, Georgakopoulos, Panagioti, Ravani, Ifigeneia, Prekates, Athanasio, Sakellaridis, Konstantino, Christopoulos, Christo, Vrettou, Efstratia, Stokkos, Konstantino, Pentari, Anastasia, Marmanidou, Kyriaki, Kydona, Christina, Tsoumaropoulos, Georgio, Bitzani, Militisa, Kontou, Paschalina, Voudouris, Antonio, Flioni, Elli-Nikki, Antypa, Elli, Chasou, Eleftheria, Anisoglou, Souzana, Papageorgiou, Eirini, Paraforou, Theoniki, Tsioka, Agoritsa, Karathanou, Antigoni, Vakalos, Aristeidi, Shah, Bhagyesh, Thakkar, Chirag, Jain, Nikhilesh, Gurjar, Mohan, Baronia, Arvind, Sathe, Prachee, Kulkarni, Shilpa, Paul, Cherish, Paul, John, Masjedi, Mansoor, Nikandish, Reza, Zand, Farid, Sabetian, Golnar, Mahmoodpoor, Ata, Hashemian, Seyed Mohammadreza, Bala, Miklosh, Flocco, Romeo, Torrente, Sergio, Pota, Vincenzo, Spadaro, Savino, Volta, Carlo, Serafini, Giulia, Boraso, Sabrina, Tiberio, Ivo, Cortegiani, Andrea, Misseri, Giovanni, Barbagallo, Maria, Nicolotti, Davide, Forfori, Francesco, Corradi, Francesco, Pelagalli, Lorella, Brazzi, Luca, Vittone, Ferdinando Giorgio, Russo, Alessandro, Simion, Davide, Cotoia, Antonella, Toppin, Gilda Cinnella Patrick, Johnson-Jackson, Roxanne, Hayashi, Yoshiro, Yamamoto, Ryohei, Yasuda, Hideto, Kishihara, Yuki, Shiotsuka, Junji, Sanchez-Hurtado, Luis Alejandro, Tejeda-Huezo, Brigitte, Gorordo, Lui, Ñamendys-Silva, Silvio A, Garcia-Guillen, Francisco J, Martinez, Manuel, Romero-Meja, Erick, Colorado-Dominguez, Ever, van den Oever, Huub, Kalff, Karel Martijn, Vermeijden, Wytze, Cornet, Alexander Daniel, Beck, Oliver, Cimic, Nedim, Dormans, Tom, Bormans, Laura, Bakker, Jan, Van Duijn, Ditty, Bosman, Gerrit, Vos, Piet, Kesecioglu, Jozef, Haas, Lenneke, Henein, Akram, Miranda, Ariel M, Malca, Gonzalo Ernesto Gianella, Arroyo-Sanchez, Abel, Misiewska-Kaczur, Agnieszka, Akinyi, Frisch, Czuczwar, Miroslaw, Luczak, Karolina, Sulkowski, Wiktor, Tamowicz, Barbara, Swit, Beata, Baranowski, Bronisław, Smuszkiewicz, Piotr, Trojanowska, Iwona, Rzymski, Stanislaw, Sawinski, Mariusz, Trosiak, Marta, Mikaszewska-Sokolewicz, Malgorzata, Alves, Ricardo, Leal, Dina, Krystopchuk, Andriy, Mendonca, Pedro Muguel Hilario, Pereira, Rui Antune, de Carvalho, Maria Raquel Lopes Marque, Candeias, Carlo, Molinos, Elena, Ferreira, Amélia, Castro, Guiomar, Pereira, José-Manuel, Santos, Lurde, Ferreira, Alcina, Pascoalinho, Dulce, Ribeiro, Rosa, Domingos, Guilherme, Gomes, Pedro, Nora, David, Costa, Rui Pedro, Santos, Anabela, Alsheikhly, Ahmed Subhy, Popescu, Mihai, Grigoras, Ioana, Patrascanu, Emilia, Zabolotskikh, Igor, Musaeva, Tatiana, Gaigolnik, Deni, Kulabukhov, Vladimir, Belskiy, Vladislav, Zubareva, Nadezhda, Tribulev, Maxim, Abdelsalam, Ahmed, Aldarsani, Ayman, Al-Khalid, Muhammad, Almekhlafi, Ghaleb, Mandourah, Yasser, Doklestic, Krstina, Velickovic, Jelena, Velickovic, Dejan, Jankovic, Radmilo, Skoric-Jokic, Svetlana, Radovanovic, Dragana, Richards, Guy, Alli, Ahmad, Cordoba Nielfa, del Carmen, Iniesta, Rafael Sánchez, Martínez, Adela Benítez-Cano, Bernedo, Carlos Garcia, Gil, Santiago Alberto Pico, Nuvials, Xavier, Garcia, Joseba Gonzalez, Peña, Jose Manuel Garcia, Jimenez, Roberto, Herrera, Lui, Barrachina, Laura Galarza, Monzon, Ignacio Catalan, Redondo, Francisco Javier, Villazala, Ruben, Zapata, Diego Fernando Matallana, Lopez, Isabel Maria Villa, Moreno-Gonzalez, Gabriel, Lopez-Delgado, Juan Carlo, Marin, Jorge Solera, Sanchez-Zamora, Purificacion, Vidal, Montserrat Vallverdú, González, Jesús Flore, Salinas, Irene, Hermosa, Cecilia, Martinez-Sagasti, Fernando, Domingo-Marín, Sara, Victorino, Johanna Abril, Garcia-Alvarez, Raquel, Calleja, Pablo López-Arca, de la Torre-Prados, Maria Victoria, Vidal-Cortes, Pablo, del Río-Carbajo, Lorena, Izura, Javier, Minguez, Victoria, Alvarez, Josep Trenado, Prous, Anna Parera, Paz, Daniel, Roche-Campo, Ferran, Aguilar, Gerardo, Belda, Javier, Rico-Feijoo, Jesu, Aldecoa, Cesat, Zalba-Etayo, Begoña, Dullenkopf, Alexander, Trongtrakul, Konlawij, Chtsomkasem, Anusang, Akbaş, Türkay, Unal, Mustafa Necmettin, Gumus, Ayca, Ramazanoglu, Atilla, Memis, Dilek, Mehmet, Inal, Urkmez, Seval, Ozgultekin, Asu, Demirkiran, Oktay, Aslan, Nesrin Ahu, Kizilaslan, Deniz, Kahveci, Ferda, Ünlü, Nurdan, Ozkan, Zeynep, Kaye, Callum, Jansen, Jan, O’Neill, Orla, Nutt, Christopher, Jha, Rajeev, Hooker, Nicola, Grecu, Irina, Petridou, Christina, Shyamsundar, Murali, McNamee, Lia, Trinder, John, Hagan, Samantha, Kelly, Catriona, Silversides, Jonathon, Groba, Casiano Barrera, Boyd, Owen, Bhowmick, Kaushik, Humphreys, Sally, Summers, Charlotte, Polgarova, Petra, Margarson, Michael, Dickens, Justin, Pearson, Suzanne, Chinery, Elaine, Hemmings, Noel, O’Kane, Sinead, Austin, Pauline, Cole, Stephen, Plowright, Catherine, Box, Roberta, Wright, Christopher, Young, Lorna, Creagh-Brown, Ben, Montague, Laura, Parker, Robert, Morton, Ben, Ostermann, Marlie, Bilinska, Julia, Rose, Bernd Oliver, Reece-Anthony, Rosie, Ryan, Christine, Hamilton, Mark, Hopkins, Philip, Wendon, Julia, Brescia, Giovanni, Ijaz, Nazia, Wood, Jame, George, Michelle, Toth-Tarsoly, Piroska, Yates, Bryan, Armstrong, Maureen, Scott, Carmen, Boyd, Christine, Szakmany, Tama, Rees, David, Pulak, Paul, Coggon, Mandy, Saha, Bhaskar, Kent, Linda, Gibson, Bethan, Camsooksai, Julie, Reschreiter, Henrik, Morgan, Pat, Sangaralingham, Sivatharshini, Lowe, Alastair, Vondras, Petr, Jamadarkhana, Sunil, Cruz, Carina, Bhandary, Rakesh, Hersey, Peter, Furneval, Julie, Innes, Richard, Doble, Patricia, Attwood, Ben, Parsons, Penny, Page, Valerie, Zhao, Xiaobei, Dalton, Julian, Hegazy, Mohammed, Awad, Yasser, Naylor, Dougla, Naylor, Amanda, Lee, Sarah, Brevard, Sidney, Davis, Noelle, Morochotutillo, Diego Rolando, Baranowski, Bronislaw, Akbas, Türkay, Mcnamee, Lia, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, and UCL - (SLuc) Service de soins intensifs

Subjects
Adult, Secondary peritoniti, Critical Illness, Peritonitis, Critical Care and Intensive Care Medicine, Anti-Bacterial Agents, Antimicrobial therapy, Intensive Care Units, Secondary peritonitis, Intra-abdominal infection, Anti-Infective Agents, Risk Factors, Source control, Sepsis, Medicine and Health Sciences, Humans, Intraabdominal Infections, Mortality, Retrospective Studies
Abstract

PURPOSE: To describe data on epidemiology, microbiology, clinical characteristics and outcome of adult patients admitted in the intensive care unit (ICU) with secondary peritonitis, with special emphasis on antimicrobial therapy and source control. METHODS: Post hoc analysis of a multicenter observational study (Abdominal Sepsis Study, AbSeS) including 2621 adult ICU patients with intra-abdominal infection in 306 ICUs from 42 countries. Time-till-source control intervention was calculated as from time of diagnosis and classified into 'emergency' (< 2 h), 'urgent' (2-6 h), and 'delayed' (> 6 h). Relationships were assessed by logistic regression analysis and reported as odds ratios (OR) and 95% confidence interval (CI). RESULTS: The cohort included 1077 cases of microbiologically confirmed secondary peritonitis. Mortality was 29.7%. The rate of appropriate empiric therapy showed no difference between survivors and non-survivors (66.4% vs. 61.3%, p = 0.1). A stepwise increase in mortality was observed with increasing Sequential Organ Failure Assessment (SOFA) scores (19.6% for a value ≤ 4-55.4% for a value > 12, p < 0.001). The highest odds of death were associated with septic shock (OR 3.08 [1.42-7.00]), late-onset hospital-acquired peritonitis (OR 1.71 [1.16-2.52]) and failed source control evidenced by persistent inflammation at day 7 (OR 5.71 [3.99-8.18]). Compared with 'emergency' source control intervention (< 2 h of diagnosis), 'urgent' source control was the only modifiable covariate associated with lower odds of mortality (OR 0.50 [0.34-0.73]). CONCLUSION: 'Urgent' and successful source control was associated with improved odds of survival. Appropriateness of empirical antimicrobial treatment did not significantly affect survival suggesting that source control is more determinative for outcome. TRIAL REGISTRATION: ClinicalTrials.gov NCT03270345.

Published
2022
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46. Gestión del mercadeo y la reputación corporativa en universidades acreditadas, privadas y públicas: Una mirada a partir del docente

Author

GUSTAVO ADOLFO MORENO LOPEZ, Jessica Maria Rojas Mora, Ledy Torcoroma Gómez Bayona, Jaime A. Orozco-Toro, and Jessica María Rojas Mora

Subjects
General Materials Science
Abstract

El objetivo de este artículo es identificar de qué manera se realizan estrategias que apoyen el mercadeo educativo y la reputación corporativa desde el docente, en siete universidades acreditadas, privadas y públicas de Medellín-Colombia. Se utilizó una metodología mixta, con entrevistas a profundidad a los directores de mercadeo de las universidades acreditadas y 231 encuestas a docentes internos de los departamentos de administración de las mismas universidades, teniendo como base para su intervención el modelo AFC (análisis factorial confirmatorio) y el modelo de ecuaciones estructurales. Se evidenció dentro de los resultados que la gestión del mercadeo ha ganado importancia en la planeación estratégica de las universidades y que de esta manera se han logrado incluir algunos stakeholders para generar más confianza, satisfacción y lealtad, con el fin de construir una mejor reputación corporativa al interior y exterior de la comunidad académica. Se concluye que los docentes, en su mayoría, se sienten satisfechos con las funciones que realizan, y que esto les permite una mayor motivación al momento de interactuar con los públicos. Sin embargo, se evidencia que pocos se sienten incorporados con las estrategias de mercadeo que se desarrollan en las universidades, lo cual puede afectar la identidad, imagen y posicionamiento de estas.

Published
2022
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47. Evidence that cervical cancer cells cultured as tumorspheres maintain high CD73 expression and increase their protumor characteristics through TGF‐β production

Author

Rosario García‐Rocha, Alberto Monroy‐García, Monserrat Carrera‐Martínez, Jorge Hernández‐Montes, Christian Azucena Don‐López, Benny Weiss‐Steider, Katia Alhelí Monroy‐Mora, María de los Ángeles Ponce‐Chavero, Juan José Montesinos‐Montesinos, María Luisa Escobar‐Sánchez, Gabriela Molina Castillo, Rommel Chacón‐Salinas, Luis Vallejo‐Castillo, Sonia Mayra Pérez‐Tapia, and María de Lourdes Mora‐García

Subjects
Clinical Biochemistry, Cell Biology, General Medicine, Biochemistry
Published
2022
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48. Palatabilidad relativa de leñosas forrajeras representativas del bosque seco tropical utilizando un método de cafetería

Author

Nelson Pérez-Almario, Jairo Mora-Delgado, Dagoberto Criollo-Cruz, Christian Thomas Carvajal-Bazurto, Jorge Mario Moreno-Turriago, and Oscar Eduardo Orjuela-Franco

Subjects
Plant Science, Agronomy and Crop Science, Ecology, Evolution, Behavior and Systematics
Abstract

Para la selección de las especies leñosas forrajeras a ser consideradas en sistemas de ganadería practicados en el ecosistema de bosque seco tropical de Colombia, se propuso utilizar como criterio la palatabilidad relativa del forraje. Para ese fin se evaluaron 20 especies que poseen características nutricionales distintas. Las especies seleccionadas se manejaron bajo podas en parcelas establecidas en el Centro de Investigación Nataima de Agrosavia. Los forrajes de esas especies fueron ofrecidos durante 19 días a cinco bovinos Blanco Orejinegro (BON) adultos, utilizando un método de cafetería con pruebas cortas de tres minutos de duración. Las especies se asignaron en pares, con un total de 190 combinaciones por animal, producto de la combinación de 20 especies tomando dos a la vez, sin repetición. La palatabilidad relativa de los forrajes se definió en función del grado de ingesta por los animales. Los resultados de las pruebas de palatabilidad identificaron nueve especies de palatabilidad muy alta y alta, las que se ordenaron así en orden descendente: Albizia niopoides, Leucaena leucocephala, Erythrina fusca, Guazuma ulmifolia, Gliricidia sepium, Tithonia diversifolia, Clitoria fairchildiana, Spondias purpurea y Spondias mombin. El par de especies que mostró la palatabilidad más alta fue la combinación A. niopoides-L. leucocephala, y la especie que se mostró con mayor frecuencia en combinaciones con ingesta alta fue A. niopoides. Se concluye que existen varias especies nativas con alta palatabilidad relativa, cuyo potencial forrajero era desconocido por técnicos y ganaderos hasta ahora, y se ratificó la palatabilidad alta para algunas especies ya conocidas.

Published
2023
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49. De las configuraciones semióticas a las configuraciones epistémicas de una tarea de dibujo geométrico: lo que se espera y lo que se implementa

Author

Elvira Garci Mora and Francisco Javier Díez Palomar

Subjects
Applied Mathematics, General Mathematics
Abstract

El uso del constructo configuración epistémica permite reflexionar sobre los objetos matemáticos movilizados en una tarea y ayuda en la identificación de conflictos cognitivos y semióticos. Lo anterior es posible al reconocer términos verbales, simbólicos y gráficos (lenguaje matemático), ejercicios y ejemplos (situaciones-problema), las definiciones, los procedimientos, las proposiciones y los argumentos utilizados en un episodio dentro del aula . El profesor en activo es consciente de las variaciones que sufre una tarea al momento de su implementación en el aula. En una implementación exitosa, los alumnos reaccionen más o menos según lo diseñado. Al utilizar herramientas de análisis didáctico, como la configuración epistémica, el profesor observa que en un episodio de clase exitoso se presentan los seis objetos primarios según se tenía previsto al momento del diseño. Cuando la implementación de la tarea no muestra las evidencias de aprendizaje previstas, el profesor puede identificar las variaciones en los objetos primarios previstos al contrastar la configuración epistémica hipotética o esperada con la configuración epistémica real o de la implementación. El objetivo de esta comunicación es valorar el nivel de éxito de la implementación de una tarea de dibujo geométrico, dirigida a alumnos de secundaria, al contrastar sus estados hipotético e implementado. De acuerdo con los resultados, la implementación fallida de la tarea se debió a desfases en los seis objetos primarios de la configuración epistémica.

Published
2023
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50. COURAGE-ALS: a randomized, double-blind phase 3 study designed to improve participant experience and increase the probability of success

Author

Jeremy M. Shefner, Ammar Al-Chalabi, Jinsy A. Andrews, Adriano Chio, Mamede De Carvalho, Bettina M. Cockroft, Philippe Corcia, Philippe Couratier, Merit E. Cudkowicz, Angela Genge, Orla Hardiman, Terry Heiman-Patterson, Robert D. Henderson, Caroline Ingre, Carlayne E. Jackson, Wendy Johnston, Noah Lechtzin, Albert Ludolph, Nicholas J. Maragakis, Timothy M. Miller, Jesus S. Mora Pardina, Susanne Petri, Zachary Simmons, Leonard H. Van Den Berg, Lorne Zinman, Stuart Kupfer, Fady I. Malik, Lisa Meng, Tyrell J. Simkins, Jenny Wei, Andrew A. Wolff, and Stacy A. Rudnicki

Subjects
Neurology, Neurology (clinical)
Published
2023
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