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To evaluate the impact of selected clinical parameters on the mid-/long-term visual outcome of patients with acute retinal necrosis (ARN) A retrospective cohort study Two University Hospitals (Parma, Italy; Lausanne, Switzerland). Thirty-nine non-HIV patients (39 eyes) with ARN, as confirmed by polymerase chain reaction on intraocular samples. The following potential predictors were tested using linear regression models: age, sex, etiology, best-corrected visual acuity (BCVA) on admission, delay between ARN symptom onset and treatment initiation, and surgery (performed or not). BCVA at the final follow up Thirty-nine of 39 non-HIV patients (22 men and 17 women; mean age, 50 years) diagnosed with ARN were enrolled in the study. Etiologies were: varicella-zoster virus in 25 eyes (64%), herpes simplex viruses in the remaining 14 eyes. The average follow-up duration was 19 ± 13 months. All patients had undergone systemic antivirals; surgery was performed in 16 eyes. The mean delay between onset of visual symptoms and antiviral treatment initiation was 15 ± 31 days (range, 1–180 days). The mean BCVA at baseline was 0.83 ± 0.75 logMAR, while the mean final BCVA was 0.75 ± 0.81 logMAR. Both initial BCVA and treatment delay (TD) were significantly correlated with the final BCVA (p

Supplemental material, sj-docx-3-ejo-10.1177_11206721211034649 for Non-infectious uveitis burden on quality of life and work impairment assessed through different psychometric questionnaires by Luca Cimino, Piergiorgio Neri, Elisabetta Miserocchi, Maria Pia Paroli, Lorenzo Vannozzi, Leonardo Mastropasqua, Caterina Gagliano, Maria Vadalà, Michele Figus, Francesca Romana Florio, Barbara Iaccheri, Paolo Mora, Maurizio Fossarello, Paola Balestrieri, Giuliana Gualberti, Francesca Marando and Massimo Accorinti in European Journal of Ophthalmology

Supplemental material, sj-pdf-4-ejo-10.1177_11206721211034649 for Non-infectious uveitis burden on quality of life and work impairment assessed through different psychometric questionnaires by Luca Cimino, Piergiorgio Neri, Elisabetta Miserocchi, Maria Pia Paroli, Lorenzo Vannozzi, Leonardo Mastropasqua, Caterina Gagliano, Maria Vadalà, Michele Figus, Francesca Romana Florio, Barbara Iaccheri, Paolo Mora, Maurizio Fossarello, Paola Balestrieri, Giuliana Gualberti, Francesca Marando and Massimo Accorinti in European Journal of Ophthalmology

Supplemental material, sj-docx-3-ejo-10.1177_11206721211034649 for Non-infectious uveitis burden on quality of life and work impairment assessed through different psychometric questionnaires by Luca Cimino, Piergiorgio Neri, Elisabetta Miserocchi, Maria Pia Paroli, Lorenzo Vannozzi, Leonardo Mastropasqua, Caterina Gagliano, Maria Vadalà, Michele Figus, Francesca Romana Florio, Barbara Iaccheri, Paolo Mora, Maurizio Fossarello, Paola Balestrieri, Giuliana Gualberti, Francesca Marando and Massimo Accorinti in European Journal of Ophthalmology

Supplemental material, sj-docx-1-ejo-10.1177_11206721211034649 for Non-infectious uveitis burden on quality of life and work impairment assessed through different psychometric questionnaires by Luca Cimino, Piergiorgio Neri, Elisabetta Miserocchi, Maria Pia Paroli, Lorenzo Vannozzi, Leonardo Mastropasqua, Caterina Gagliano, Maria Vadalà, Michele Figus, Francesca Romana Florio, Barbara Iaccheri, Paolo Mora, Maurizio Fossarello, Paola Balestrieri, Giuliana Gualberti, Francesca Marando and Massimo Accorinti in European Journal of Ophthalmology

Supplemental material, sj-docx-2-ejo-10.1177_11206721211034649 for Non-infectious uveitis burden on quality of life and work impairment assessed through different psychometric questionnaires by Luca Cimino, Piergiorgio Neri, Elisabetta Miserocchi, Maria Pia Paroli, Lorenzo Vannozzi, Leonardo Mastropasqua, Caterina Gagliano, Maria Vadalà, Michele Figus, Francesca Romana Florio, Barbara Iaccheri, Paolo Mora, Maurizio Fossarello, Paola Balestrieri, Giuliana Gualberti, Francesca Marando and Massimo Accorinti in European Journal of Ophthalmology

Supplemental material, sj-pdf-4-ejo-10.1177_11206721211034649 for Non-infectious uveitis burden on quality of life and work impairment assessed through different psychometric questionnaires by Luca Cimino, Piergiorgio Neri, Elisabetta Miserocchi, Maria Pia Paroli, Lorenzo Vannozzi, Leonardo Mastropasqua, Caterina Gagliano, Maria Vadalà, Michele Figus, Francesca Romana Florio, Barbara Iaccheri, Paolo Mora, Maurizio Fossarello, Paola Balestrieri, Giuliana Gualberti, Francesca Marando and Massimo Accorinti in European Journal of Ophthalmology

Supplemental material, sj-docx-2-ejo-10.1177_11206721211034649 for Non-infectious uveitis burden on quality of life and work impairment assessed through different psychometric questionnaires by Luca Cimino, Piergiorgio Neri, Elisabetta Miserocchi, Maria Pia Paroli, Lorenzo Vannozzi, Leonardo Mastropasqua, Caterina Gagliano, Maria Vadalà, Michele Figus, Francesca Romana Florio, Barbara Iaccheri, Paolo Mora, Maurizio Fossarello, Paola Balestrieri, Giuliana Gualberti, Francesca Marando and Massimo Accorinti in European Journal of Ophthalmology

Supplemental material, sj-pdf-5-ejo-10.1177_11206721211034649 for Non-infectious uveitis burden on quality of life and work impairment assessed through different psychometric questionnaires by Luca Cimino, Piergiorgio Neri, Elisabetta Miserocchi, Maria Pia Paroli, Lorenzo Vannozzi, Leonardo Mastropasqua, Caterina Gagliano, Maria Vadalà, Michele Figus, Francesca Romana Florio, Barbara Iaccheri, Paolo Mora, Maurizio Fossarello, Paola Balestrieri, Giuliana Gualberti, Francesca Marando and Massimo Accorinti in European Journal of Ophthalmology

Supplemental material, sj-pdf-5-ejo-10.1177_11206721211034649 for Non-infectious uveitis burden on quality of life and work impairment assessed through different psychometric questionnaires by Luca Cimino, Piergiorgio Neri, Elisabetta Miserocchi, Maria Pia Paroli, Lorenzo Vannozzi, Leonardo Mastropasqua, Caterina Gagliano, Maria Vadalà, Michele Figus, Francesca Romana Florio, Barbara Iaccheri, Paolo Mora, Maurizio Fossarello, Paola Balestrieri, Giuliana Gualberti, Francesca Marando and Massimo Accorinti in European Journal of Ophthalmology

Cogan's syndrome (CS) is a rare autoimmune vasculitis characterized by ocular inflammation and sensorineural hearing loss. CS is divided into a "typical" form with non-syphilitic interstitial keratitis and audiovestibular symptoms, and an "atypical" form with ocular involvement affecting structures other than the cornea. Anti-Hsp70 antibodies were found at variable levels in patients presenting with various forms of autoimmune sensorineural hearing loss (ASNHL).To assess the correlation between anti-Hsp70 antibodies and specific ASNHL subgroups.We divided 112 subjects into four groups: 14 subjects with typical CS, 24 with atypical CS, 55 with ASNHL, and 19 control subjects (healthy subjects and patients with systemic autoimmune diseases but no sensorineural hearing or audiovestibular alterations). Patients were tested for serological autoimmunity markers including anti-Hsp70.Positivity of the anti-Hsp70 antibody test was highest in the typical CS group (92.9%) and lowest in the control group (5.2%). The test was positive in 52.7% of patients in the ASNHL group and 16.6% in the atypical CS group. The paired comparison analysis between groups showed that sensitivity of anti-Hsp70 in the typical CS group was significantly higher, as compared to the other three study groups.Anti-Hsp70 antibodies can be considered a serological marker of "typical" CS. "Atypical" CS is conceivably a sort of "melting pot" of different forms of autoimmune diseases still characterized by ocular inflammation and sensorineural hearing loss but whose antigenic characteristics need to be further defined.

The aim of this study was to investigate the chemical and physical surface properties of a hybrid nano-hydroxyapatite/collagen/polycaprolactone (nHA/Coll/PCL) material, and to test its in vitro biocompatibility and in vivo osteointegration. Mineralized collagen fibers with nHA were admixed with PCL at a weight proportion of 50:50. The material was characterized by transmission X-ray diffraction (XRD), electron microscopy (TEM), atomic force microscopy (AFM), force spectroscopy, X-ray Photoemission Spectroscopy (XPS), and biocompatibility testing using human mesenchymal stem cells (MSCs), and Hepatocyte carcinoma (HePG2) and primary osteogenic sarcoma (SAOS-2) cells as complementary tests. In addition, the ability of this material to fill three-wall bony defects was tested in the mandible of a sheep. The material had confirmed the relative low crystallinity of the HA having a nano-sized dimension, which was composed of only oxygen, carbon, calcium and phosphorus, without no residual cytotoxic element. Human MSCs on the surface scaffold showed high metabolic activity and a high rate of viability. Biocompatibility complementary testing using HePG2 and SAOS-2 cells showed good metabolic activity, and the lactate dehydrogenase assay using HePG2 cells demonstrated no significant cytotoxicity. Histological analysis of the in-vivo experimentation showed osteointegration of the material and the absence of inflammatory cells at the bone–scaffold interface. Some areas showed bone-cell seeding and isolated agglomerates of bone cells were evident in the inner scaffold.