1. Late gestation predictors of a postnatal biventricular circulation after fetal aortic valvuloplasty
- Author
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Lynn A. Sleeper, Meaghan J Beattie, Louise Wilkins-Haug, Kevin G. Friedman, Ryan Callahan, Carol B. Benson, Minmin Lu, Monika Drogosz, Aaron R. Prosnitz, Terra Lafranchi, Audrey C. Marshall, and Wayne Tworetzky
- Subjects
Balloon Valvuloplasty ,Male ,0301 basic medicine ,Aortic arch ,medicine.medical_specialty ,medicine.medical_treatment ,Hemodynamics ,Gestational Age ,030105 genetics & heredity ,Hypoplastic left heart syndrome ,Cohort Studies ,03 medical and health sciences ,Fetus ,0302 clinical medicine ,Pregnancy ,medicine.artery ,Internal medicine ,medicine ,Humans ,Genetics (clinical) ,Retrospective Studies ,Foramen ovale (heart) ,030219 obstetrics & reproductive medicine ,Ejection fraction ,business.industry ,Obstetrics and Gynecology ,Aortic Valve Stenosis ,medicine.disease ,Aortic valvuloplasty ,Stenosis ,Logistic Models ,medicine.anatomical_structure ,Blood Circulation ,Cardiology ,Female ,business - Abstract
OBJECTIVES Fetal aortic valvuloplasty (FAV) for severe aortic stenosis (AS) has shown promise in averting progression to hypoplastic left heart syndrome. After FAV, predicting which fetuses will achieve a biventricular (BiV) circulation after birth remains challenging. Identifying predictors of postnatal circulation on late gestation echocardiography will improve parental counseling. METHODS Liveborn patients who underwent FAV and had late gestation echocardiography available were included (2000-2017, n = 96). Multivariable logistic regression and classification and regression tree analysis were utilized to identify independent predictors of BiV circulation. RESULTS Among 96 fetuses, 50 (52.1%) had BiV circulation at the time of neonatal discharge. In multivariable analysis, independent predictors of biventricular circulation included left ventricular (LV) long axis z-score (OR 3.2, 95% CI 1.8-5.7, p
- Published
- 2021
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