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1. Milk and Dairy Products Intake Is Related to Cognitive Impairment at Baseline in Predimed Plus Trial

Author

Garach AM, Cornejo-Pareja I, Martínez-González MÁ, Bulló M, Corella D, Castañer O, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Bernal-López MR, Lapetra J, Pintó X, Tur JA, López-Miranda J, Bueno-Cavanillas A, Delgado-Rodríguez M, Matía-Martín P, Daimiel L, Sánchez VM, Vidal J, Prieto L, Ros E, Fernández-Aranda F, Camacho-Barcia L, Ortega-Azorin C, Soria M, Fiol M, Compañ-Gabucio L, Goicolea-Güemez L, Pérez-López J, Goñi N, Pérez-Cabrera J, Sacanella E, Fernández-García JC, Miró-Moriano L, Gimenez-Gracia M, Razquin C, Paz-Graniel I, Guillem P, Zomeño MD, Moñino M, Oncina-Canovas A, Salaverria-Lete I, Toledo E, Salas-Salvadó J, Schröder H, Tinahones FJ, and Predimed-Plus Investigators

Subjects
cognition, milk, consumption, dairy products, cognitive decline
Abstract

Scope To examine the association between milk and dairy products intake and the prevalence of cognitive decline among Spanish individuals at high cardiovascular risk. Methods and results Cross-sectional analyses are performed on baseline data from 6744 adults (aged 55-75 years old). Intake of milk and dairy products is estimated using a food frequency questionnaire grouped into quartiles. The risk of developing cognitive impairment is based on the Mini-Mental State Examination (MMSE). A higher prevalence of cognitive decline was found in subjects who consumed more grams. Patients with worse MMSE score (10-24) consumed a mean of 395.14 +/- 12.21 g, while patients with better MMSE score (27-30) consumed a mean of 341.23 +/- 2.73 g (p < 0.05). Those subjects with the lower milk consumption (

Published
2021

2. Health-related quality of life in individuals with metabolic syndrome: A cross-sectional study

Author

Marcos-Delgado A, López-García E, Martínez-González MA, Salas-Salvadó J, Corella D, Fitó M, Romaguera D, Vioque J, Alonso-Gómez AM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Fernández-García JC, Lapetra J, Pintó X, Tur JA, López-Miranda J, Cano-Ibañez N, Delgado-Rodríguez M, Matía-Martín P, Daimiel L, Carriedo E, Vidal J, Vázquez C, Ros E, Lozano-Oloriz E, Bulló M, Sorlí JV, Zomeño MD, Fiol M, González-Palacios S, Sorto-Sánchez C, Pérez-Farinós N, Goñi-Ruiz N, Sanchez-Villegas A, Muñoz-Garach A, Santos-Lozano JM, Galera A, Bouzas C, Toledo E, Babio N, González JI, Del Val-García JL, Moñino M, Martínez-Vergaran MC, Goicolea-Güemez L, Galilea-Zabalza I, Basora J, Muñoz MA, Builf P, Fernández-Villa T, and PREDIMED-Plus investigators

Subjects
Metabolic Syndrome, Health-Related, Well-being, Quality of Life, PREDIMED-Plus, Obesity, Weight-lass
Abstract

Introduction and objectives: Metabolic syndrome (MetS) is a combination of various cardiovascular risk factors with a major impact on morbidity and premature mortality. However, the impact of MetS on self-reported health-related quality of life (HRQoL) is unknown. This study evaluated the HRQoL in a Spanish adult population aged 55 years and older with MetS. Method: A cross-sectional analysis was performed with baseline data from the PREDIMED-Plus multicentre randomized trial. The participants were 6430 men and women aged 55-75 years with overweight/obesity (body mass index >= 27 and

Published
2020

3. Health-related quality of life in individuals with metabolic syndrome: A cross-sectional study

Author

Marcos-Delgado A, López-García E, Martínez-González MA, Salas-Salvadó J, Corella D, Fitó M, Romaguera D, Vioque J, Alonso-Gómez AM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Fernández-García JC, Lapetra J, Pintó X, Tur JA, López-Miranda J, Cano-Ibañez N, Delgado-Rodríguez M, Matía-Martín P, Daimiel L, Carriedo E, Vidal J, Vázquez C, Ros E, Lozano-Oloriz E, Bulló M, Sorlí JV, Zomeño MD, Fiol M, González-Palacios S, Sorto-Sánchez C, Pérez-Farinós N, Goñi-Ruiz N, Sanchez-Villegas A, Muñoz-Garach A, Santos-Lozano JM, Galera A, Bouzas C, Toledo E, Babio N, González JI, Del Val-García JL, Moñino M, Martínez-Vergaran MC, Goicolea-Güemez L, Galilea-Zabalza I, Basora J, Muñoz MA, Builf P, Fernández-Villa T, and PREDIMED-Plus investigators

Subjects
Metabolic Syndrome, Health-Related Quality of Life, Weight-loss, Obesidad, PREDIMED-Plus, Obesity, Bienestar, Pérdida de peso, Calidad de vida relacionada con la salud, Well-being
Abstract

INTRODUCTION AND OBJECTIVES: Metabolic syndrome (MetS) is a combination of various cardiovascular risk factors with a major impact on morbidity and premature mortality. However, the impact of MetS on self-reported health-related quality of life (HRQoL) is unknown. This study evaluated the HRQoL in a Spanish adult population aged 55 years and older with MetS. METHOD: A cross-sectional analysis was performed with baseline data from the PREDIMED-Plus multicentre randomized trial. The participants were 6430 men and women aged 55-75 years with overweight/obesity (body mass index =27 and =40kg/m(2)) and MetS. The SF-36 questionnaire was used as a tool to measure HRQoL. Scores were calculated on each scale of the SF-36 by gender and age. RESULTS: Participants showed higher scores in the social function (mean 85.9, 95% CI; 85.4-86.4) and emotional role scales (mean 86.8, 95% CI; 86.0-87.5). By contrast, the worst scores were obtained in the aggregated physical dimensions. In addition, men obtained higher scores than women on all scales. Among men, the worst score was obtained in general health (mean 65.6, 95% CI; 65.0-66.2), and among women, in body pain (mean 54.3, 95%CI; 53.4-55.2). A significant decrease was found in the aggregated physical dimensions score among participants 70-75 years old, but an increased one in the aggregated mental dimensions, compared to younger participants. CONCLUSIONS: Our results reflect that the MetS may negatively affect HRQoL in the aggregated physical dimensions, body pain in women, and general health in men. However, this adverse association was absent for the psychological dimensions of HRQoL, which were less affected.

Published
2020

4. Health-related quality of life in individuals with metabolic syndrome: A cross-sectional study

Author

Marcos-Delgado A, López-García E, Martínez-González MA, Salas-Salvadó J, Corella D, Fitó M, Romaguera D, Vioque J, Alonso-Gómez AM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Fernández-García JC, Lapetra J, Pintó X, Tur JA, López-Miranda J, Cano-Ibañez N, Delgado-Rodríguez M, Matía-Martín P, Daimiel L, Carriedo E, Vidal J, Vázquez C, Ros E, Lozano-Oloriz E, Bulló M, Sorlí JV, Zomeño MD, Fiol M, González-Palacios S, Sorto-Sánchez C, Pérez-Farinós N, Goñi-Ruiz N, Sanchez-Villegas A, Muñoz-Garach A, Santos-Lozano JM, Galera A, Bouzas C, Toledo E, Babio N, González JI, Del Val-García JL, Moñino M, Martínez-Vergaran MC, Goicolea-Güemez L, Galilea-Zabalza I, Basora J, Muñoz MA, Builf P, Fernández-Villa T, and PREDIMED-Plus investigators

Subjects
Metabolic Syndrome, Health-Related, Well-being, Quality of Life, PREDIMED-Plus, Obesity, Weight-lass
Abstract

Introduction and objectives: Metabolic syndrome (MetS) is a combination of various cardiovascular risk factors with a major impact on morbidity and premature mortality. However, the impact of MetS on self-reported health-related quality of life (HRQoL) is unknown. This study evaluated the HRQoL in a Spanish adult population aged 55 years and older with MetS. Method: A cross-sectional analysis was performed with baseline data from the PREDIMED-Plus multicentre randomized trial. The participants were 6430 men and women aged 55-75 years with overweight/obesity (body mass index >= 27 and

Published
2020

6. Recommended domestic handling of fruits and vegetables to preserve their nutritional value,Recomendaciones de manipulación doméstica de frutas y hortalizas para preservar su valor nutritivo

Author

Basulto, J., Moñino, M., Farran, A., Eduard Baladia, Manera, M., Cervera, P., Romero-De-Ávila, M. D., Miret, F., Astiasarán, I., Bonany, J., Gelabert, V., Ballesteros, J. M., Martínez, A., Palou, A., Labrador, J., Marques-Lopes, I., Russolillo, G., Alonso, M., Riquelme, F., Polanco, I., Rodríguez-Artalejo, F., and Martínez, N.

7. Dietary α-Linolenic Acid, Marine ω-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study

Author

Sala-Vila, A., Guasch-Ferré, Marta, Hu, F.B., Sánchez-Tainta, A., Bulló, M., Serra-Mir, M., López-Sabater, C., Sorlí, J.V., Arós, F., Fiol, M., Muñoz, M.A., Riera, C., Francés, F., Vinyoles, E., Guarner, A., Márquez, F., Guillén, M., Rovira, M.A., Piñol, J.L., Sacanella, E., Basora, T., García, Y., Rovira, A., Santamaría, M.I., Mata, M., de Juan, C., Ruiz-Gutiérrez, Valentina, Pages, M.A., Brau, A., Urtasun-Samper, A., Ruano, C., Tresserra-Rimbau, A., de Santamaría, L., Llopis-Osorio, E., Marti, A., Chiva, G., Moñino, M., Mitjavila, M.T., Valderas, P., Arranz, S., Carrasco, P., Alonso Gómez, A., Galera, A., Alonso, A., Baena, J.M., Basterra-Gortari, F. Javier, Carratalá-Calvo, A., Gil Zarzosa, J., García, M., Pérez-Heras, A., Frontera, G., Oller, M., Benavent, J., Gea, A., Ginard, M., Amat, J., Gueto Rubio, M.V., Diaz-López, A., Clos, J., Pla, I., Amorós, M., Bonet, M.T., Baby, P., de la Torre, Rafael, Martín, M.T., Lapetra, José, Lamuela-Raventós, Rosa M., García-Valdueza, M., Sánchez, M.S., Martin, F., Macías-Gutiérrez, B., Altirriba, J., Tort, R., Isach, A., Fitó, Montserrat, Sarmiendo De La Fe, F., Romero, S., Costa, B., Elosúa, R., García, L., Cabré, J.J., Babio, N., Santana-Santana, A.J., Fernández-Ballart, J., Hernández, J.M., García García, M., Ibarrola-Jurado, Nuria, San Vicente, J., Toledo, E., Buil-Cosiales, P., Ruiz-Canela, M., Vargas López, E., Simón, C., de Diego Salas, J., Sanjulián, B., Felipe, I., Falcón-Sanabria, I., Serra-Majem, L., Trias, F., Díez-Espino, Javier, Viñas, C., Martínez, E., Extremera-Urabayen, V., Núñez-Córdoba, J.M., Proenza, A., Santos, J.M., García-Arellano, A., Marrugat, J., González, J.I., Ferrer, M., Arroyo-Azpa, C., García-Pérez, L., Villanueva-Tellería, J., Cortés-Ugalde, F., Gilabert, R., de la Cruz, E., Sagredo-Arce, T., Ros, E., Duaso, I., Jurado-Ruíz, Enrique, Sarasa, I., De La Noceda-Montoy, M.D.G., Saiz, C., Mengual, L., Vigata-López, M.D., Portolés, O., Giménez, F.J., Montero Romero, Emilio, Verdú, J.M., Martínez, P., Coltell, O., Ortiz, A.P., Soler, Y., Cofán, M., Guillem-Saiz, P., Osma, R., Yuste, M.C., Quiles, L., Ruiz-Baixauli, J., Estruch, R., Pascual, V., Baca Osorio, A., Fiol, F., Bertolín-Muñoz, A., Salaverría, I., del Hierro, T., Corella, D., Razquin, C., Portillo, M.P., Algorta, J., Sánchez Luque, J.J., Ramos, A., Francisco, S., Jover, A., Parra, L., García, J., Covas, María Isabel, Medina-Remón, Alexander, Iglesias, C., Tello, S., Sáez, G., Zazpe, I., Salas-Salvadó, J., Prieto, R., Liroz, M., Vila, J., Álvarez-Pérez, J., Molina, C., Schröder, H., Díaz Benítez, E., Bautista-Castaño, Inmaculada, Martínez-González, M.A., Doménech, M., Godoy, D., Manzano, E., Maldonado-Díaz, I., Flores, G., Quinzavos, L., Churio-Beraza, B., Sánchez-Villegas, A., Barragán, R., Sorli, M., Castro, I., Gómez-Gracia, Enrique, Roura, P., García Roselló, J., Henríquez, P., Tur, J., Ortega-Calvo, M., Fernández-Crehuet, Joaquín, Benítez Pont, R., Bianchi Alba, M., Wärnberg, J., Loma-Osorio, A., Alegret, C., Gómez-Huelgas, R., Asensio, E.M., Alfredo Martínez, J., Bargalló, N., Martínez-González, J., Román, P., Bes-Rastrollo, M., Velasco García, V., García, F.José, Iglesias, P., González, R., Goñi, E., Muñoz-Aguayo, Daniel, Corchado, Y., Millán, S., Sanz, E., Mayoral, E., Leal, M., Martínez-Lapiscina, E.H., Lama, C., Padres, E., Ortega-Azorín, C., Pintó, Xavier, Altés, A., Figueras, R., Solanich, X., Pujol, R., Castellote-Bargalló, A. I., Simón-García, C., Arceiz Campo, M.T., Corbella, E., Valls-Pedret, C., Serrano-Martínez, M., Casas, R., Martín-Rillo, M.J., Cabezas, C., Universitat de Barcelona, Instituto de Salud Carlos III, Centro Nacional de Investigaciones Cardiovasculares (España), and Ministerio de Ciencia e Innovación (España)

Subjects
Male, Gerontology, Time Factors, Epidemiology, modelos de riesgos proporcionales, humanos, 030204 cardiovascular system & hematology, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, estudios prospectivos, evaluación de riesgos, Medicine, Nuts, Sudden cardian death, 030212 general & internal medicine, Food science, Longitudinal Studies, Prospective Studies, mediana edad, Original Research, Diet and Nutrition, Aged, 80 and over, chemistry.chemical_classification, education.field_of_study, anciano, alpha-Linolenic acid, dieta, Factors de risc en les malalties, Hàbits alimentaris, Fatty Acids, ω-3 fatty acids, Fatty acids in human nutrition, alpha-Linolenic Acid, distribución de la ji al cuadrado, Middle Aged, Cardiovascular system, nutrition, Cardiovascular Diseases, Female, Dieta, Cardiology and Cardiovascular Medicine, Nutritive Value, conducta de reducción del riesgo, Risk factors in diseases, Food habits, Population, enfermedades cardiovasculares, 030209 endocrinology & metabolism, Juglans, Risk Assessment, sudden cardiac death, 03 medical and health sciences, alimentos del mar, factores de tiempo, Mediterranean cooking, Àcids grassos en la nutrició, Fatty Acids, Omega-3, Cuina mediterrània, Peix com a aliment, Humans, factores de riesgo, análisis multifactorial, education, Olive Oil, Dieta -- Mediterrània, Regió de la, Dieta mediterranea, ácidos grasos, α-linolenic acid, Aged, Proportional Hazards Models, Sistema cardiovascular, Chi-Square Distribution, business.industry, Correction, Fatty acid, Hàbits alimentaris -- Mediterrània, Regió de la, Protective Factors, Fish consumption, Predimed, Diet, nueces, chemistry, Seafood, Spain, Multivariate Analysis, valor nutritivo, estudios longitudinales, fatty acid, business, Risk Reduction Behavior, ácido alfa-linolénico
Abstract

12 Páginas.-- 6 Tablas.-- 1 Figura, Background-Epidemiological evidence suggests a cardioprotective role of α-linolenic acid (ALA), a plant-derived ω-3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω-3 fatty acids (long-chain n-3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0.7% of total energy) at baseline was related to all-cause and cardiovascular disease mortality. We also examined the effect of meeting the society's recommendation for long-chain n-3 polyunsaturated fatty acids (≥500 mg/day). Methods and Results-We longitudinally evaluated 7202 participants in the PREvención con DIeta MEDiterránea (PREDIMED) trial. Multivariable-adjusted Cox regressionmodels were fitted to estimate hazard ratios. ALA intake correlated towalnut consumption (r=0.94). During a 5.9-y follow-up, 431 deaths occurred (104 cardiovascular disease, 55 coronary heart disease, 32 sudden cardiac death, 25 stroke). The hazard ratios formeeting ALArecommendation (n=1615, 22.4%) were 0.72 (95% CI 0.56-0.92) for all-causemortality and 0.95 (95% CI 0.58-1.57) for fatal cardiovascular disease. The hazard ratios formeeting the recommendation for long-chain n-3 polyunsaturated fatty acids (n=5452, 75.7%) were 0.84 (95% CI 0.67-1.05) for all-causemortality, 0.61 (95% CI 0.39-0.96) for fatal cardiovascular disease, 0.54 (95% CI 0.29-0.99) for fatal coronary heart disease, and 0.49 (95% CI 0.22-1.01) for sudden cardiac death. The highest reduction in all-cause mortality occurred in participants meeting both recommendations (hazard ratio 0.63 [95% CI 0.45-0.87]). Conclusions-In participants without prior cardiovascular disease and high fish consumption, dietary ALA, supplied mainly by walnuts and olive oil, relates inversely to all-cause mortality, whereas protection from cardiac mortality is limited to fish-derived long-chain n-3 polyunsaturated fatty acids., This study was funded in part by Instituto de Salud Carlos III (ISCIII) (Spanish Ministry of Economy) through grants RTIC G03/140, RTIC RD 06/0045, Centro Nacional de Investigaciones Cardiovasculares CNIC 06/2007, ISCIII FIS PS09/01292, the Spanish Ministry of Science and Innovation (MICINN) AGL2010‐22319‐C03‐02 and AGL2009‐13906‐C02‐02, and an unrestricted grant from the California Walnut Commission. Sala‐Vila holds a Miguel Servet I fellowship from the Ministry of Economy and Competitiveness through the ISCIII.

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