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Additional file 6: Figure S2. Structural organisation of pfhrp2 amino acid repeats types. Type 1, when is present, appeared always at the beginning of the sequence with 1 to 5 consecutives repeats following by various consecutive type 2 repeats. In the middle of the sequences, there were different numbers of consecutive type 2 repeats usually mixed with type 4, type 5, type 6, type 7 and type 8, but there was not any clear pattern. At the end of the sequence, usually appeared a unique type 12 repeat, preceded by type 10 repeat.

Additional file 2. Custom code used in Python for analysis of aminoacidic repetition types.

Additional file 1: Table S1. Origin of homologous sequences included for phylogenetic analysis.

Additional file 5: Table S4. Occurrence and number of variations of Baker’s amino acid repeats types in pfhrp2 and pfhrp3 sequences. *Amino acid repeats types described by Nderu et al. [61]. ^New amino acid repeats types

Additional file 4: Table S3. Haplotypes frequency of not—unique samples in pfhrp2 and pfhrp3 by sampling located in Ahmara region. Figure S1. Haplotype networks of pfhpr2 (a) and pfhrp3 (b). Colour represents different sample The size of the circles are proportional to the number of sequences include in each haplotype.

Additional file 3: Table S2. Frequencies of deletion patterns of exon 2 of pfhrp2 and pfhrp3 genes by location.

Additional file 8: Figure S4. Tertiary protein structure models according to template-based prediction.

Additional file 7: Figure S3. Structural organisation of pfhrp3 amino acid repeats types. The most common organisation of repeats started with one repeat type 1 followed by one repeat type 15 and around 10 consecutive repeats of type 16 ending with one repeat of type 7. Then, after a space of 33 aa without classified repeats, there were interspersed repeats of type 17, more abundant, and type 18. It ends with two repeats of type 4.

Additional file 1: Table S1. The PRISMA checklist.

Additional file 8: Figure S6. Assessment of inter-study heterogeneity for the pfhrp2 & pfhrp3 double deletion analysis.

Additional file 2: Table S2. Pooled prevalence of pfhrp2, pfhrp3 and pfhrp2/3 deletions among all P. falciparum cases by WHO region, population symptomatology, age of population and collection season.

Additional file 6: Figure S4. Assessment of inter-study heterogeneity for the pfhrp2 deletion analysis.