1. Effect of NaFeEDTA-Fortified Soy Sauce on Anemia Prevalence in China: A Systematic Review and Meta-analysis of Randomized Controlled Trials
- Author
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Moench-Pfanner Regina, Zhen Xin Lu, Jun Shi Chen, Jing Sun, Chunming Chen, Ji Yong Yin, Jian Huang, and Jun Sheng Huo
- Subjects
China ,medicine.medical_specialty ,Anemia ,Health, Toxicology and Mutagenesis ,Population ,Cochrane Library ,Hematocrit ,Ferric Compounds ,law.invention ,Randomized controlled trial ,law ,Internal medicine ,Prevalence ,medicine ,Humans ,education ,Edetic Acid ,Randomized Controlled Trials as Topic ,education.field_of_study ,Anemia, Iron-Deficiency ,Traditional medicine ,medicine.diagnostic_test ,business.industry ,Age Factors ,Public Health, Environmental and Occupational Health ,Soy Foods ,Odds ratio ,medicine.disease ,Meta-analysis ,Food, Fortified ,Hemoglobin ,business - Abstract
Objective To assess the effect of sodium iron ethylenediaminetetraacetate (NaFeEDTA)-fortified soy sauce on anemia prevalence in the Chinese population. Methods A systematic review was performed to identify potential studies by searching the electronic databases of PubMed, Cochrane Library, WHO Library, HighWire, CNKI, and other sources. The selection criteria included randomized controlled trials that compared the efficacy of NaFeEDTA-fortified soy sauce with that of non-fortified soy sauce. Anemia rates and hemoglobin levels were the outcomes of interest. Inclusion decisions, quality assessment, and data extraction were performed by two reviewers independently. A total of 16 studies met the inclusion criteria for anemia rate analysis, of which 12 studies met the inclusion criteria for hemoglobin analysis. All included studies assessed the effect of NaFeEDTA-fortified soy sauce on anemia rates and hemoglobin concentrations. Results After the intervention, the hemoglobin concentration increased and anemia rates decreased significantly as compared with the non-fortified soy sauce groups. For anemia rates, data from 16 studies could be pooled, and the pooled estimate odds ratio was 0.25 (95% CI 0.19-0.35). For hemoglobin concentrations, data from 12 studies could be pooled, and the pooled weighted mean difference was 8.81 g/L (95% CI 5.96-11.67). Conclusion NaFeEDTA-fortified soy sauce has a positive effect on anemia control and prevention in the at-risk population.
- Published
- 2015