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Three mixed ligand complexes of copper(II) with adenine and dicarboxylic acids have been synthesized. The resulting complexes were characterized by their melting point, solubility, metal content analysis, FT-IR and UV-visible spectroscopy, magnetic measurement, thermal analysis, cyclic voltammetric measurement and X-ray powder diffraction study. The products are microcrystalline powder, slightly soluble in water and decompose at high temperature. Under experimental condition, the ligands adenine (Ade) behaves as a neutral ligand, whereas oxalic acid (OxH2), succinic acid (SucH2) and tartaric acid (TarH2) are doubly deprotonated to form dianionic ligands that are coordinated to the Cu(II) ion. The Cu(II) content analysis of the complexes confine to their stoichiometry [Cu(Ade)(L)(H2O)] (L = Ox, Suc, or Tar dianion). Electrochemical redox behavior of the complexes in their reaction medium was also examined. They exhibit quasi-reversible one-electron transfer processes. Dhaka Univ. J. Sci. 69(2): 76-81, 2021 (July)

There have been developed a novel synthetic method that allowed to obtain raw of mixed-ligand heterometallic binuclear complexes of Ge(IV)-M2+ (Mn, Fe, Co, Ni, Zn) with 1,3-diamino‑2-hydroxypropane N, N, N’, N’-tetraacetic acid (H5hpdta). Compounds have been characterized by the set of methods: elemental analysis, thermogravimetry, IR‑spectroscopy, spectrum of diffuse reflection, magnetic suspensibility. According to the elemental analysis, the molar ratio Ge: M: H5hpdta: bipy= 1:1:1:1 in the obtained compounds 1‑5 corresponds to the formula [(H2O)(OH)Ge(m-hpdta)M(bipy)]·nН2О (M=Mn n=3 (1), Fe n=2 (2), Co n=4 (3), Ni n=4 (4), Zn n=3 (5). Complexes have yellow (1), red (2), orange (3), violet (4) and pink (5) colors and are stable on air. Compounds 1‑5 exist in the form of crystal hydrates, that contain certain amount of water molecules, that are eliminated into the gas phase while heating in the wide range of temperatures (t=80‑250 °C), which is accompanied with the low-temperature endothermic effect. This indicates the presence of a system of stable hydrogen bonds in their crystal structure. Analysis of the IR‑spectra 1‑5 revealed that form and coordination of ligands is similar. Deprotonation of all carboxylic groups in the ligands (H5hpdta) and their bonding to germanium and d-metal is confirmed with the absence in the IR‑spectra 1‑5 absorption bands characteristic for the free СООН H5hpdta (1716 сm‑1) and nas(СОО-) і ns(СОО-) bands. Disappearance of the ν(С-OН)-1210 сm‑1 and appearance of the ν(С-O)alk., νas(Ge-O-M), νs(Ge-O- M) absorption band indicates that OH‑group of H5hpdta is deprotonated and performs bridging function. 2,2`-bipyridine bidentatly coordinates to the d-metal, binds to the O, N‑atoms of hpdta5- ligand and reaches coordination number 6. The last ligand plays the bringing role between Ge-dmetal, shows itself as ditopic, octadentate in total. According to the magnetic moments of 3, 4 and their diffuse reflection spectra, polyhedrons of Co (II), Ni (II) are octahedrons, which are realized due to the bidentate coordination of bipyridine and four bonds with nitrogen and oxygen of hpdta5-. Structure of heterometallic binuclear complexes 1‑5 is similar. Ligand hpdta5- shows itself as octadentate ditopic, all carboxylate groups monodentatly coordinate to metals, oxygen atom of the deprotonated OH‑group performs the bridging function.

In the present study, through employing the mixed ligands of tetrakis(4-carboxyphenyl)silane (H4TCS) and 1,4-bis(2-methylimidazol-1-yl)benzene (BMIB), we have triumphantly created two coordination polymers (CPs) [Co2(TCS)(BMIB)2](DMF)3(H2O)2 (1) and [Co2(H2TCS)2(BMIB)2] (2) with the reaction between the H4TCS ligand and BMIB ligand and Co(NO3)2·6H2O in distinct systems of solvent. Their application values on the acute myocardial infarction were assessed, and then their corresponding mechanism was investigated. Firstly, the ELISA detection assay was performed for the detection of the inflammatory cytokines levels released into plasma during acute myocardial infarction. In addition to this, the real-time RT-PCR was performed and the lncRNA-CAIF levels were determined.

Reactions of Zn(NO3)2·6H2O, 2-iodobenzoic acid (2-IBA), and 4-ethyl- or 3-chloropyridine result in the formation of binuclear neutral complexes [Zn2(2-IBA)4L2] (L = 3-ClPy (1), 4-EtPy (2)) whose structures are analyzed by X-ray crystallography. The structure of 2 has specific noncovalent I⋯I interactions.

Sulfamethoxazole and metronidazole are antibiotics use for the treatment of various bacterial infections. Their use as ligand is very prominent in formation of metal complexes. The transition metal complexes are synthesized by reaction of Sulfamethoxazole and metronidazole with metals such Mn(II), Cu(II), Fe(II) and Ni(II). The synthesized metal complexes are tested as antibacterial and antifungal. The antimicrobial activity of the complexes displays good potency against some microorganism such as Xanthomonas axonopodis, Streptococcus faecalia, Salmonella entrica, Claribacter michiganense, Xanthomonas phaseolin for bacteria and S.roofisii, M.phonoides, C.lindimuthianum for the fungi, it is revealed that all copper complexes show stronger antibacterial activity than the free drugs. The spectroscopic properties of the complexes were investigated using UV/visible and FT-IR which show metal-charge from 3d to 3s transition in which the transition state shows that they are octahedral geometry and their coordination site respectively. Their percentage yield was moderately high and producible. The complexes synthesized have higher inhibitory activities than the free ligand. The drug resistance in microbes is resulting in the incompetence of available drugs to care for the infections. The thermal analysis shows that the complexes are stable.

Through precisely adjusting the pH value of reaction system, two new mixed-ligand based coordination polymers, namely [Zn(ip)0.5(bta)]n (1) and [Zn3(Hip)4(bta)2]n (2) (H2ip = isophthalic acid, Hbta = benzotriazole), have been acquired through the self-assemble reaction of Zn(II) salts in combination with H2ip and Hbta. Both compounds have high thermal stability demonstrated by the thermogravimetric analysis (TGA) experiments, and exhibit strong luminescence emission at room temperature. Their application values on the children bone growth and development were evaluated and the specific mechanism was examined simultaneously. Above all, compound 1 was more outstanding than compound 2 against the children bone growth and development by regulating the Vitamin K receptor on the bone cell surface.

In the current study, by using the mixed ligand approach, a novel 2D metal–organic framework (MOF), [Zn(Hssa)(1,4-dtb)·H2O]n (H3ssa = 5-sulfosalicylic acid, dtb = 1,4-di(4H-1,2,4-triazol-4-yl)benzene) was synthesized with a high yield under solvothermal reaction conditions and through the elemental analysis and the single-crystal X-ray diffraction. Luminescence studies demonstrate that 1 is able to be utilized as a strongly sensitive luminescent sensor for Cr2O72− and CrO42− in H2O. Furthermore, the neuroprotective effect of the compound on CO poisoning patients was evaluated in biological research. The real-time RT-PCR was conducted to study the expression level of the ROS-related genes in the neurons. In addition to this, the activation of the superoxide dismutase (SOD) in the neurons was measured after treatment of the compound.

Dentate ligands 2-[(2,3-dimethylphenyl)amino]benzoic acid (Mefenamic acid ) and 2,5-diamino-5-oxopentanoic acid(glutamine) were used as bidentate Lewis base to prepare solid complexes with Molybdenum (V), Tungsten (V)) and Lanthanum(III). The Photo degradation study was achieved for the complexes solutions in methanol. The prepared complexes were characterized by using spectroscopy methods like FTIR, UV-visible, Melting points and flame atomic absorption spectroscopy were calculated for all complexes. Furthermore the molar conductance of 0.001 M solutions in acetonitrile and magnetic susceptibility were performed to elucidate the proposed geometry and structures of prepared complexes. Magnetic susceptibility displayed that complexes had not diamagnetic properties. Photo kinetic study was done for La and Mo Complexes to study the photo sensitivity of prepared complexes. Half time of the complexes` photo reaction were achieved and order of reactions were calculated which appear that photo reaction of LaIII complex was from the first order and constant of reaction was calculated (1.62x10-2) min-1 and half time of reaction was (62.112) min. Also, order reaction of Mo (III) complex was from first order too, the value of constant of reaction was (1.88 min-1) and half time of reaction was (26.6) min. TGA analysis of MoIII was done.

The effectiveness of the use of mixed ligand complexes of Zinc, Manganese and Cobalt in the diets of high-yielding cows in the final period of lactation, and their effect on productivity, nutrients digestibility and nitrogen metabolism in the animals’ body was studied in a scientific economic experiment conducted at the Terezyne Ltd. of Bila Tserkva district, Kyiv region. Five groups of highly productive cows of Holstein, Ukrainian red-spotted and Ukrainian black-spotted dairy breeds were selected on the principle of analogues. The difference in feeding cows of the groups was in the following: - the diet of the control 1st group was balanced to the norm only with trace elements of Selenium, Copper and Iodine. - cows of the 2nd and 3d experimental group were fed with the norm of all trace elements (for the 2nd experimental groupthe norm was provided due to introducing sulfates of Zinc, Manganese, Cobalt, Copper, Selenium Suplex and Potassium iodide; for the 3d experimental group , sulfates of Zinc, Manganese and Cobalt were substituted with their mixed ligand complexes). - for cows of 4th experimental group, the concentration of Zinc, Manganese and Cobalt in 1 kg of dry matter feed was reduced by 11% compared to the group 3. - for the 5thgroup it was 22% lower than in the group 3. The results of the studies show that the use different doses of mixed ligand complexes of Zinc, Manganese, Cobalt in cows feeding with the use of Selenium Suplex, Copper sulfate and Potassium iodide during the final 100 days of lactation did not affect milk productivity. Each cow of the control group in the final period of lactation yielded 2220 kg of natural milk, whereas the cows of the experimental groups 2-5 yielded 40-120 kg more. The difference in the average daily milk yield of 4% fat was 0.5–1.91 kg, and this difference was significant (p

No Abstract.

By the reaction of a rigid π-conjugated H4L linker (5,5′-(1,3,6,8-tetraoxobenzo[lmn][3],[8]phenanthroline-2-7-diyl)bis-1,3-benzenedicarboxylic acid), Cu(NO3)2, and N-donor auxiliary linkers, two new Cu-based coordination polymers (CPs), namely {[Cu(L)0.5(1,4-bib)(H2O)2]·0.5H2O}n (1) and {[Cu(H2L)(4,4′-bibp)(H2O)2]}n (2) {1,4-bib = 1,4-bis(1-imidazolyl)benzene, 4,4′-bibp = 4,4′-bis(imidazolyl)biphenyl} are synthesized under solvothermal conditions and characterized. Furthermore, the protective effect of compounds 1 and 2 on the sepsis mice model is evaluated and the related mechanism is explored. Firstly, the CFU counting assay is performed to detect the bactericidal effect of compounds 1 and 2 in vivo. Then, the ELISA assay is conducted to measure the release of interleukin-1β (IL-1β) and interleukin-6 (IL-6) into the plasma after treatment with the compounds.

The reactions of ReI3, Se, and KCN with Sb2O3 or Bi2O3 at elevated temperature led to the formation of two new tetrahedral clusters with mixed-ligand cluster cores {Re4Se3Sb}7+ and {Re4Se3Bi}7+. Th...

New mixed-ligand heteronuclear complexes of lanthanum and cobalt (nickel) with acetylacetone (НАА) and α,α'-dipyridyl were synthesized and investigated by physic-chemical methods of analysis (eleme...

The metal complexes {Ni (II), Co (II) and Mn (II)} of 3-(2-(aryl)hydrazono)acetylacetone with isatin were synthesized and screened for their in vitro antibacterial activity against four pathogenic microorganisms {two Gram‐positive and two Gram negative}. The results of antibacterial activities revealed that all the metal complexes 1-9 exhibited moderate activities. Also, Lipinski's rule of five (RO5) of the mixed ligand metal complexes were calculated by SwissADME website. KEY WORDS: Isatin, 3-(2-(Aryl)hydrazono)acetylacetone, Metal complexes, Antibacterial activities, Lipinski rules Bull. Chem. Soc. Ethiop. 2020, 34(3), 533-541. DOI: https://dx.doi.org/10.4314/bcse.v34i3.9

Transition metal carboxylates with O- and N-donor ligands are interesting for their structural features. Seven novel isonicotinamide(inic)-based metal complexes of [Cd(inic)2(L1)2(H2O)2] · 2H2O (1)...

A new Cu(II) coordination polymer (CP) of [Cu5(µ3-OH)2(bcpt)4(bib)2] (1, bib = 1,4-bis(1-imidazoly)benzene and H2bcpt = 3,5-bis(3′-carboxyphenyl)-1,2,4-triazole) was synthesized by reaction of Cu(N...

In this current experiment, by applying the mixed-ligand synthesis method, two coordination polymers (CPs) containing Co(II) were created triumphantly with reaction between 1,3-bis(1-imidazoly)benzene (mbib) and Co(II) salts with the aid of diverse carboxylic ligands, and their chemical formulae are [Co3(opda)3(mbib)4(H2O)4]·2H2O (1, H2opda is 1,2-phenylenediacetic acid) and [Co(mpda)(mbib)]·H2O (2, H2mpda is 1,3-phenylenediacetic acid). The two compounds’ magnetic performances suggest that between the adjacent metal ions, there present the antiferromagnetic coupling. The evaluation of their treatment activity against chronic subdural hematoma was carried out and the relevant mechanism was studied simultaneously. Firstly, before the treatment of compound, the chronic subdural hematoma was generated. Furthermore, the enzyme-linked immunosorbent assay detection kit was implemented and in hematoma capsule, the anti-inflammatory cytokines level and pro-inflammatory cytokines level was detected. Additionally, the cytotoxicity of compounds 1 and 2 on the normal human cells was determined with Cell Counting Kit-8 assay. Above all, we proved compound 1 decreased the pro-inflammatory cytokines content and increased the anti-inflammatory cytokines content in the hematoma capsule, which is much stronger than that of compound 2. Both compounds 1 and 2 showed no cytotoxicity on the normal human cells.

Metformin is one of the most effective drugs for the treatment of type II diabetes. Two new mixed ligand complexes of vanadyl(ii) and chromium(iii) ions with the general formula [VOL1L2]SO4 and [CrL1L2(Cl)2]Cl, respectively, where L1 is the metformin and L2 is the glycine amino acid, have been synthesized in MeOH solvent with 1:1:1 stoichiometry and characterized by several spectroscopic techniques. The spectroscopic data suggested that the [VOL1L2]SO4 complex possesses a square pyramidal geometry, where the [CrL1L2(Cl)2]Cl complex possesses an octahedral geometry. The L1 ligand coordinated to the VO(ii) and Cr(iii) ions via the N atoms of the imino (‒C═NH) groups, where the L2 ligand coordinated via the O atom of the carboxylate group (COO) and the N atom of the amino group (NH2). The interaction of ligands L1 and L2 with the metal ions leads to complexes that have organized nanoscale structures with a main diameter of ∼14 nm for the [CrL1L2(Cl)2]Cl complex and ∼40 nm for the [VOL1L2]SO4 complex.

A series of mixed ligand complexes with a Schiff base (HL1) (obtained from 2-hydrazinobenzimidazole and ohydroxyacetophenone) acts as primary ligand and 1,10-phenanthroline (secondary ligand, L2) have been synthesized and investigated by various physico-analytical techniques. The spectral results suggested the tridentate nature of the Schiff base with NNO donor type. The prepared complexes exhibited distorted octahedral geometry. Moreover, molecular docking studies have been carried out against the SARS-CoV-2 spike receptor-binding domain (PDB ID: 6M0J) and SARS-CoV spike receptor-binding domain (PDB ID: 2AJF).

By utilizing the mixed-ligand method, two novel metal-organic frameworks (MOFs) based on Zn(II) ions as nodes with the chemical formulae of {[Zn2.5(abta)(trz)2(H2O)]·3H2O}n (1, Htrz = 1H-1,2,4-triazole) and [Zn3(abta)2(bibb)2]n (2, bibb = 1,4-bis(benzimidazol-1-yl)-2-butene) were produced via Zn(NO3)2·6H2O reacting with the 1-aminobenzene-3,4,5-tricarboxylic acid (H3abta) in the existence of distinct nitrogen-donor co-ligands. The different N-donor ligands result in their distinct framework structures, and the compound 1 with higher solvent accessible void and large window size shows highly heterogeneous catalytic activities for Knoevenagel condensation. The treatment of Staphylococcus aureus biofilms formation during spine surgery incision infection and the related mechanism was explored at the same time. First of all, the S. aureus bacterial numbers in the infectious site was measured under compound 1 or 2 treatment. In addition to this, the relative expression levels of the genes related with S. aureus biofilms was determined with real time RT-PCR.

The coordination compounds of propanedioic acid with cobalt(II), nickel(II) and copper(II) ions were synthesized using metal:ligand 1:2. In addition to this, mixed ligand complexes using the same metal ions with propanedioic acid as the primary ligand and N,N'-dihydroxy-2,3-butanediimine as the secondary ligand were also synthesized using M:L1:L2 (1:1:1) where L1 = propanedioic acid, L2 = N,N'-dihydroxy-2,3-butanediimine and M = Cu(II), Ni(II) and Cu(II). The synthesized compounds were characterized using FTIR, UV-vis, magnetic susceptibility measurement and percentage metal composition. The ligand and its metal complexes were tested for their cytotoxic and antibacterial activities. Results indicated that a dimeric square planar geometry was assumed by the cobalt(II) and nickel(II) propanedioic acid complexes. Octahedral geometry was proposed for both cobalt(II) and copper(II) mixed ligand complexes. A dinuclear square pyramidal geometry was suggested for the copper(II) propanedioic acid complex and square planar/octahedral geometry for the nickel(II) mixed ligand complex. The copper(II) propanedioic acid complex elicited the best cytotoxic activity. On the other hand, the nickel(II) propanedioic acid complex showed the remarkable antimicrobial activity. The compounds exhibited good antimicrobial activity in most of the cases with the exception of the cobalt(II) propanedioic acid complex. It was concluded that coordination of the ligands to the metal ions lowered the toxicity of the ligands. It was further concluded that the antimicrobial activity of the compounds was partly dependent on the synergism/additive effect of the intrinsic therapeutic properties of the metal ion and the ligands within the coordination sphere of the complexes synthesized. And this is also in part a function of the geometry assumed by the complexes.

Based on 5-dimethylamino-isophthalic acid (H2dia) and 1,2-bis(4-pyridyl)ethylene (bpe) mixed linkers, a new Cu(II) coordination polymer material, [Cu(dia)(bpe)(H2O)]n (1), has been successfully pre...

By a bifunctional organic ligand 2-(benzimidazol-1-yl)terephthalic acid (H2bitp) featuring both imidazol-carboxylate groups, two new Cu(II)-containing coordination polymers (CPs) with the chemical ...

Among several strategies related to cancer therapy targeting the modulation of αβ-tubulin has shown encouraging findings, more specifically when this is achieved by inhibitors located at the colchicine binding site. In this work, we aim to fish new αβ-tubulin modulators through a diverse and rational VS study, and thus, exhibiting the development of two VS pipelines. This allowed us to identify two compounds 5 and 9 that showed IC50 values of 19.69 and 21.97 μM, respectively, towards possible modulation of αβ-tubulin, such as assessed by in vitro assays in C6 glioma and HEPG2 cell lines. We also evaluated possible mechanisms of action of obtained hits towards the colchicine binding site of αβ-tubulin by using docking approaches. In addition, assessment of the stability of the active (5 and 9) and inactive compounds (3 and 13) within the colchicine binding site was carried out by molecular dynamics (MD) simulations, highlighting the solvent effect and revealing the compound 5 as the most stable in the complex. At last, deep analysis of these results provided some valuable insights on the importance of using mixed ligand- and structure-based strategies in VS campaigns, in order to achieve higher chemical diversity and biological effect as well.

Four mixed-ligand metal(II) complexes with the molecular formulae [M(ofl)(bipy)]NO3�H2O and [M(ofl)(phen)]NO3�H2O were synthesized by the reaction of Co(II) and Ni(II) with ofloxacin (Hofl) in the presence of 1,10-phenanthroline (phen) / 2,2`-bipyridine (bipy) (1:1:1 molar ratio). The data obtained from elemental analysis, molar conductance, spectral infrared, reflectance spectra and magnetic studies gave information about the coordination of the ligands and the geometry of the metallic ion. The results suggest that Hofl is deprotonated and bidentately bound to the metal ion through the pyridone oxygen and the carboxylato oxygen while phen and bipy act as neutral bidentate ligands coordinated through the nitrogen atoms. Tetrahedral geometry is proposed for all complexes. Thermal analysis data led to useful information concerning the composition, dehydration and thermal behaviour of the complexes. Ofloxacin and the metal complexes were tested for antibacterial activity and also for antioxidant activity. The variations of physicochemical parameters were monitored, which explain the antibacterial behaviour of these compounds. The interactions between metal complexes and bacterial receptors have lower energy values compared to the ofloxacin ligand. The molecular docking studies allow the identification of the biological target and the predictions of the bonds between the studied compounds and the receptors of E. coli (3t88), S. aureus (3q8u) and P. aeruginosa (4lkd).

Two new mixed-ligand coordination polymers based on the Ni(II) ion as the metal center [Ni(L1)(DCTP)] n (1, L1 = 1,1′-(1,4-butanediyl)bis-1H-benzimidazole) and [Ni(L2)(DCTP)] n (2, L2 = 1,4-bis(5,6...

Two new mixed-ligand coordination polymers (CPs) with the chemical formulae of [Co(L)(phen)]n (1, phen = 1,10-phenanthroline and [Co(L)(4,4′-bipy)4·2H2O]n (2, 4,4′-bipy = 4,4′-bipyridine) have been...

By applying the mixed-ligand method, a new Co(II)-based coordination polymer with the chemical formula of {[Co2L(4,4′-bipy)0.5(H2O)] · 0.25H2O}n (1) have been successfully prepared by reaction of C...

The Co2+–triglycine–L-histidine system is studied in an aqueous solution at Т = 298.15 K (KNO3) via potentiometry and calorimetry. The formation of mixed-ligand CoL2Y− complex is established, and the standard thermodynamic characteristics (ΔrH°, ΔrG°, ΔrS°) of the complexation reaction are determined. A structure is proposed for this complex.

We report the synthesis of two isoreticular, mixed-ligand metal–organic frameworks (MOFs), [Cd(μ2-mia)(μ2-bpe)]n·n(DMF)0.5·n(H2O)0.5 (1) and [Cd(μ2-nia)(μ2-bpee)]n·nDMF (2), where mia = 5-methoxyis...

In the current study, two new transition metal-organic coordination polymers (CPs) with the chemical formula of [Cu(L)(OBA)(H2O)]n (1) and [Co(L)(OBA)]n (2) (H2OBA = 4,4(L)(OBA)]dy, two new traL = ...

Mixed-ligand Cu(I) complexes have attracted attention as alternatives to the noble- and/or rare-metal complexes, because of their remarkable photofunctions. To develop mixed-ligand Cu(I) complexes with rich photofunctions, an investigation of a suitable combination of ligands has captured more and more research interests. Herein, we report the first examples of emissive heteroleptic diphosphine-disulfide Cu(I) complexes combined with diphosphine ligands. The systematic study using a series of diphosphine ligands revealed that large π-conjugated bridging moieties between the two P atoms in the diphosphine ligands result in higher light-emission performance. When the diphosphine ligand was (

Two new mixed-ligand coordination polymers with the chemical formulae of {[Co(L1)(bdc)](H2O)}n (1, L1 = 1,4-bis((1H-benzo[d]imidazol-1-yl)methyl)benzene, H2bdc = terephthalic acid) and {[Co(L2)(bdc...

In the current study, a novel mixed-ligand coordination polymer, {[Co(L)(dpe)]·(ClO4)} (1) (H2LCl = 3-carboxy-1-(3-carboxybenzyl)pyridin-1-ium, dpe = (E)-1,2-di(pyridin-4-yl)ethene), was synthesize...

Two mixed-ligand coordination polymers with the chemical formulae {[Cu3(Hdpc)2(tib)2(H2O)2]·2H2O)}n (1, H3dpc = 2,6-di(4-carboxylphenyl)pyridine-4-carboxylic acid, tib = 1,3,5-tris(1-imidazolyl)benzene)) and [Cu(trans-chda)2(bimb)2·2H2O]n (2, H2chda = 1,4-cyclohexane(dicarboxylic)acid, bimb = 1,4-bis((1H-1,2,4-triazol-1-yl)methyl)benzene) are successfully prepared by the reaction of Cu(NO3)2·3H2O with different O-donor carboxylic acid and N-donor co-ligands under the solvothermal conditions. Furthermore, the treatment effect of the two compounds on the acute pancreatitis is evaluated in the biological experiment. Firstly, RT-PCR is performed to measure the relative expression level of the key genes of E. coli. Moreover, the inflammatory levels of the patients are evaluated by the ELISA detection of inflammatory cytokines, IL-1β, and TNF-α.

In the current study, two new Cu(II)-containing coordination polymers (CPs) with the chemical formula of {[Cu2(Py2TTz)(2-CH3-BDC)2]·2(DMF)·3(H2O)}n (1, 2-CH3-H2BDC = 2-methyl-1,4-benzenedicarboxyli...

Two Co(II)-containing coordination polymers, {Co(TDC)(TPB)0.5·H2O}n (1) and {[Co2(2,6-NDC)2(TPB)]·MeCN·3H2O}n (2) (TPB = 1,2,4,5-tetra(4-pyridyl)benzene, H2TDC = 2,5-thiophenedicarboxylic acid, 2,6...

A new 3D Cd(II) coordination polymer, {[Cd2(btc)(HL)(H2O)]·3H2O}n (1) (H2L= 3-(1H-pyrazol-4-yl)-5-(pyridin-2-yl)-1, 2, 4-triazole; H3btc = 1,3,5-benzenetricarboxylic acid), has been synthesized by ...

By using a mixed-ligand approach, two new coordination polymers with the chemical formula of {[Zn(L)(ip)·H2O]8}n (1, H2ip = isophthalic acid and L = 1,1’-(2-methylpropane-1,3-diyl)bis(1H-benzo[d]im...