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We have developed a simple and rapid mix-and-read assay for the sensitive detection of O6-methylguanine DNA methyltransferase activity.

Background. Previous studies have suggested a link between Helicobacter pylori (H. pylori) infection and nonalcoholic fatty liver disease (NAFLD), yet long-term follow-up studies to elucidate this association are lacking. We aimed to identify the relationship between NAFLD and H. pylori in these people. Methods. A total of 2,934 adults between June 2013 and October 2017 were collected; among them, 675 people met the requirements. People were assessed for H. pylori infection diagnosis as detected by the carbon-13 urea breath test; they were also assessed for NAFLD diagnosis by ultrasound. Results. H. pylori infection was present in 206 patients (30.5%), and 469 (69.5%) participants were classified as controls. Participants with H. pylori infection had a higher rate of incident NAFLD than those who were uninfected (37/206; 18% versus 73/469; 15.6%) ( p < 0.001 ). Compared with the control group, the recovery rate of NAFLD in the H. pylori+ve group was low (6/206, 2.9% versus 33/469, 7.0%) ( p < 0.001 ). Besides, the incidence of uric acid, postprandial blood glucose, TG, LDL-C, HDL-C, and fasting plasma glucose was significantly different between the two groups ( p < 0.001 ), but no difference was found in alanine aminotransferase (ALT), liver-total protein, urea nitrogen, and cholesterol ( p > 0.05 ). Conclusion. H. pylori infection was a risk factor for NAFLD and affected the occurrence or reversal of NAFLD, indicating that H. pylori infection eradication might play a role in reducing the risk of NAFLD.

Ultrasound can accelerate and change the reaction process and is widely used in the field of hydrogen production and storage. In this study, ultrasound (US) and AlOOH suspension (AH) are used to promote hydrogen production from Al hydrolysis. The results indicate that both US and AH greatly shorten the induction time and enhance the hydrogen production rate and yield. The promoting effect of US and AH on Al hydrolysis originates from the acoustic cavitation effect and catalytic effect, respectively. When AH is used in combination with US, Al hydrolysis has the best hydrogen production performance and the hydrogen yield can reach 96.6 % within 1.2 h, because there is a synergistic effect on Al hydrolysis between AH and US. Mechanism analyses reveal that the micro-jets and local high temperature environment arising from acoustic cavitation improve the catalytic activity of AlOOH, while the suspended AlOOH particles enhance the cavitation effect of US. This work provides a novel and feasible method to promote hydrogen production from Al hydrolysis.

We have developed a simple and rapid mix-and-read assay for the sensitive detection of O

Chinese medicine (CM) has thousands of years of experience in prevention of diseases. As for CM, people's constitution is closely related to their health status, thus recognition of CM constitution is the fundamental and core content of research on constitution types. With development of technologies such as sensors, artificial intelligence and big data, objectification of the four diagnostic methods of CM has gradually matured, bringing changes in the mindset and innovations in technical means for recognition of CM constitution. This paper presents a systematic review of the latest research trends in constitution recognition based on objectification of diagnostic methods in CM.

Objectives. To investigate whether Helicobacter pylori (H. pylori) infection increases the risk of colorectal adenomatous polyp (CAP) in the context of age and gender. Methods. A total of 563 study subjects (male/female, 368/195) from Beijing, China, with higher nursing level who underwent colonoscopy were retrospectively collected. H. pylori and CAP were detected by carbon-13 urea breath test and colorectal colonoscopy. The correlations between the number, size, distribution, and pathological grade of CAP and H. pylori infection were analyzed. The population was further stratified by age and gender in order to examine the risk of H. pylori and CAP in the context of these variables. The influence of H. pylori on the risk of CAP was assessed by logistic regression model. Results. 315 participants were diagnosed with CAP, and 207 participants were classified as healthy controls. The prevalence of H. pylori in the CAP group was significantly higher than that in the healthy control group (119/315, 37.8% versus 44/207, 21.3%) (p<0.001). The proportion of H. pylori positive plus CAP in participants 50 years old (87/250; 34.8% versus 32/65; 49.2%) (p=0.033). Furthermore, H. pylori infection was identified as one of the major risk factors of CAP (OR=2.679; 95% CI: 1.717-4.179, p<0.001), independent of age, sex, and body mass index and was correlated with size, distribution, and pathological grading of CAP (p<0.001). Conclusions. H. pylori is a major risk factor for CAP. Further studies are needed to assess the effects of H. pylori treatment or persistent infection on the occurrence or recurrence of CAP.

A 38-year-old male patient was diagnosed as acute non-ST-segment elevation myocardial infarction on Apr 21st 2021 and he received percutaneous transluminal coronary angioplasty for RCA via transradial artery access. He sought for second percutaneous coronary intervention in our center for frequently exertional angina on Sep 13th 2021. Proximal right radial artery pulsation can not be touched in physical examination, indicating right radial artery occlusion (RAO). Distal transradial access was applied and RAO was confirmed via angiography. With balloon pre-dilation, the guidewire and guiding catheter crossed the occlusion and coronary intervention was successfully completed. A Reewarm 2.5 × 220 mm paclitaxel drug-coated balloon (Endovastec, China) was released at 12 atm in radial arterial lesion with 90 s. Pulsation of radial artery can be well palpated 24 h after PCI. No oral anticoagulant was added. The right radial artery remained patent after 8-month and 14-month follow-up and there was no abnormal sensation or obstacle of right hand.

Background Androgen has been implicated in aging-related cardiac remodeling, but its precise role in aging heart remains controversial. We aimed to investigate the role of testosterone in the development of aging-related cardiac remodeling and the mechanisms involved. Methods Wild type and Axl knockout mice (Axl−/−) were randomized into three groups: the young group (n = 30, 3 months old), the aging group (n = 30, 18 months old), the testosterone undecanoate treatment group (TU, n = 30, 18 months old). Mice in the TU group were given testosterone undecanoate (39 mg/kg) by subcutaneous injection on the back at fifteen-months-old, once a month, a total of three times. The old group received solvent reagent (corn oil) by the same method. Results The aging mice exhibited a decrease in serum testosterone, and Gas6 levels and an increase in apoptosis, and manifested cardiac fibrosis. Testosterone injection to wild type mice increased the levels of testosterone and Gas6 in serum and decreased cardiac apoptosis and fibrosis. Axl−/−mice receiving testosterone injection exhibited no obvious improvement in cardiac remodeling although the levels of testosterone and Gas6 in serum elevated. Conclusions These data indicated that testosterone replacement therapy (TRT) alleviates cardiac fibrosis and apoptosis, at least in part by enhancing Gas6 expression. Moreover, deletion of Axl disables testosterone, which indicated that Axl is an important downstream regulator of testosterone. TRT would improve aging-related cardiac remolding via Gas6/Axl signaling pathway, implicating its therapeutic potential to treat aging-related heart disease.

High-mobility graphene hosting massless charge carriers with linear dispersion provides a promising platform for electron optics phenomena. Inspired by the physics of dielectric optical micro-cavities where the photon emission characteristics can be efficiently tuned via the cavity shape, we study corresponding mechanisms for trapped Dirac fermionic resonant states in deformed micro-disk graphene billiards and directed emission from those. In such graphene devices a back-gate voltage provides an additional tunable parameter to mimic different effective refractive indices and thereby the corresponding Fresnel laws at the boundaries. Moreover, cavities based on single-layer and double-layer graphene exhibit Klein- and anti-Klein tunneling, respectively, leading to distinct differences with respect to dwell times and resulting emission profiles of the cavity states. Moreover, we find a variety of different emission characteristics depending on the position of the source where charge carriers are fed into the cavites. Combining quantum mechanical simulations with optical ray tracing and a corresponding phase-space analysis, we demonstrate strong confinement of the emitted charge carriers in the mid field of single-layer graphene systems and can relate this to a lensing effect. For bilayer graphene, trapping of the resonant states is more efficient and the emission characteristics do less depend on the source position., 12 pages, 12 figures

We study transport in twisted bilayer graphene and show that electrostatic barriers can act as valley splitters, where electrons from the $K$ ($K'$) valley are transmitted only to e.g.\ the top (bottom) layer, leading to valley-layer locked currents. We show that such a valley splitter is obtained when the barrier varies slowly on the moir\'e scale and induces a Lifshitz transition across the junction, i.e.\ a change in the Fermi surface topology. Furthermore, we show that for a given valley the reflected and transmitted current are transversely deflected, as time-reversal symmetry is effectively broken in each valley separately, resulting in valley-selective transverse focusing at zero magnetic field., Comment: 13 pages, 13 figures

Background: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries, and strongly associated with type 2 diabetes mellitus (T2DM). Several studies have shown that hypoglycemic agents are effective for NAFLD combined with T2DM. However, there is still controversy over which hypoglycemic agent is the best for NAFLD combined with T2DM patients. Objective: To systematically evaluate the efficacy and safety of hypoglycemic agents in NAFLD combined with T2DM patients. Methods: A comprehensive electronic search will be conducted by searching Web of Science, PubMed, EMBASE, Cochrane Central Register of Controlled Trials, Clinical Trials and Chinese Biomedical Medicine. All randomized controlled trials of hypoglycemic agents interventions for NAFLD combined with T2DM will be identified. Two reviewers independently screened and evaluated each included study and extracted the outcome indexes. ADDIS 1.16.8 software will be used for the network meta-analysis and STATA 14 software will be used for drawing network evidence plots and funnel plots. Conclusion: This network meta-analysis will provide stronger evidence for the efficacy and safety of hypoglycemic agents in the treatment of NAFLD combined with T2DM, and provide a reference for clinical application. Protocol registration number: INPLASY202070016.

The constituent particles of matter can arrange themselves in various ways, giving rise to emergent phenomena that can be surprisingly rich and often cannot be understood by studying only the individual constituents. Discovering and understanding the emergence of such phenomena in quantum materials-especially those in which multiple degrees of freedom or energy scales are delicately balanced-is of fundamental interest to condensed-matter research1,2. Here we report on the surprising observation of emergent ferroelectricity in graphene-based moire heterostructures. Ferroelectric materials show electrically switchable electric dipoles, which are usually formed by spatial separation between the average centres of positive and negative charge within the unit cell. On this basis, it is difficult to imagine graphene-a material composed of only carbon atoms-exhibiting ferroelectricity3. However, in this work we realize switchable ferroelectricity in Bernal-stacked bilayer graphene sandwiched between two hexagonal boron nitride layers. By introducing a moire superlattice potential (via aligning bilayer graphene with the top and/or bottom boron nitride crystals), we observe prominent and robust hysteretic behaviour of the graphene resistance with an externally applied out-of-plane displacement field. Our systematic transport measurements reveal a rich and striking response as a function of displacement field and electron filling, and beyond the framework of conventional ferroelectrics. We further directly probe the ferroelectric polarization through a non-local monolayer graphene sensor. Our results suggest an unconventional, odd-parity electronic ordering in the bilayer graphene/boron nitride moire system. This emergent moire ferroelectricity may enable ultrafast, programmable and atomically thin carbon-based memory devices.

When two dimensional crystals are atomically close, their finite thickness becomes relevant. Using transport measurements, we investigate the electrostatics of two graphene layers, twisted by θ = 22° such that the layers are decoupled by the huge momentum mismatch between the K and K′ points of the two layers. We observe a splitting of the zero-density lines of the two layers with increasing interlayer energy difference. This splitting is given by the ratio of single-layer quantum capacitance over interlayer capacitance Cm and is therefore suited to extract Cm. We explain the large observed value of Cm by considering the finite dielectric thickness dg of each graphene layer and determine dg ≈ 2.6 Å. In a second experiment, we map out the entire density range with a Fabry-Pérot resonator. We can precisely measure the Fermi wavelength λ in each layer, showing that the layers are decoupled. Our findings are reproduced using tight-binding calculations., Science Advances, 6 (11), ISSN:2375-2548

We consider graphene superlattice miniband fermions probed by electronic interferometry in magneto-transport experiments. By decoding the observed Fabry-P\'erot interference patterns together with our corresponding quantum transport simulations, we find that the Dirac quasiparticles originating from the superlattice minibands do not undergo conventional cyclotron motion but follow more subtle trajectories. In particular, dynamics at low magnetic fields is characterized by peculiar, straight trajectory segments. Our results provide new insights into superlattice miniband fermions and open up novel possibilities to use periodic potentials in electron optics experiments.

We report an efficient technique to induce gate-tunable two-dimensional superlattices in graphene by the combined action of a back gate and a few-layer graphene patterned bottom gate complementary to existing methods. The patterned gates in our approach can be easily fabricated and implemented in van der Waals stacking procedures allowing flexible use of superlattices with arbitrary geometry. In transport measurements on a superlattice with lattice constant $a=40$ nm well pronounced satellite Dirac points and signatures of the Hofstadter butterfly including a non-monotonic quantum Hall response are observed. Furthermore, the experimental results are accurately reproduced in transport simulations and show good agreement with features in the calculated band structure. Overall, we present a comprehensive picture of graphene-based superlattices, featuring a broad range of miniband effects, both in experiment and in theoretical modeling. The presented technique is suitable for studying more advanced geometries which are not accessible by other methods., Comment: This document is the unedited Author's version of a Submitted Work that was subsequently accepted for publication in Nano Letters, copyright American Chemical Society after peer review. To access the final edited and published work, as well as the Supporting Information, see the journal reference or DOI below

In this work, we analytically and experimentally present a perfect and broadband acoustic insulation waveguide composed of gradient impedance boundaries. With these designed impedance boundaries, the incident plane wave will be converted into the surface wave mode and be absorbed or reflected back. The transmission rate reaches nearly zero in a broadband (1800–7000 Hz, typically), and the bandwidth is adjustable to fit different noise spectra. Our results may contribute more possible designs for noise reduction challenges in the waveguide.

Ten-eleven translocation (TET) family proteins play key roles in multiple cellular processes by mediating the oxidation of 5-methylcytosine to directly participate in DNA demethylation, and often aberrantly expressed in various diseases. In this research, we develop a single-quantum-dot (QD)-mediated fluorescence resonance energy transfer (FRET) biosensor for amplification-free measurement of ten-eleven translocation 2 (TET2). When TET2 is present, it catalyzes the oxidation of 5-vinylcytosine in dsDNA to 5-formylmethylcytosine, and the subsequent labeling of dsDNA with Cy5 generates a biotinylated Cy5-dsDNA complex. Biotinylated Cy5-dsDNA complexes are conjugated to the streptavidin-coated 605QDs to obtain a Cy5-dsDNA-605QD nanostructures, inducing FRET from 605QD to Cy5. FRET signal can be simply measured by single-molecule counting. This biosensor enables homogeneous detection of TET2 with a limit of detection (LOD) of 0.042 ng/μL, and it can accurately measure cellular TET2 down to 1 cell. Moreover, this biosensor can be used to screen TET2 inhibitors, offering a new platform for TET2-related medical research and clinical diagnostics.

Background Atherosclerosis (AS) is the most common and serious complication of type 2 diabetes mellitus (T2DM) and is accelerated via chronic systemic inflammation rather than hyperglycemia. Adipose tissue is the major source of systemic inflammation in abnormal metabolic state. Pro-inflammatory CD4+T cells play pivotal role in promoting adipose inflammation. Adipose-derived stem cells (ADSCs) for fat regeneration have potent ability of immunosuppression and restricting CD4+T cells as well. Whether T2DM ADSCs are impaired in antagonizing CD4+T cell proliferation and polarization remains unclear. Methods We constructed type 2 diabetic ApoE−/− mouse models and tested infiltration and subgroups of CD4+T cell in stromal-vascular fraction (SVF) in vivo. Normal/T2DM ADSCs and normal splenocytes with or without CD4 sorting were separated and co-cultured at different scales ex vivo. Immune phenotypes of pro- and anti-inflammation of ADSCs were also investigated. Flow cytometry (FCM) and ELISA were applied in the experiments above. Results CD4+T cells performed a more pro-inflammatory phenotype in adipose tissue in T2DM ApoE−/− mice in vivo. Restriction to CD4+T cell proliferation and polarization was manifested obviously weakened after co-cultured with T2DM ADSCs ex vivo. No obvious distinctions were found in morphology and growth type of both ADSCs. However, T2DM ADSCs acquired a pro-inflammatory immune phenotype, with secreting less PGE2 and expressing higher MHC-II and co-stimulatory molecules (CD40, CD80). Normal ADSCs could also obtain the phenotypic change after cultured with T2DM SVF supernatant. Conclusion CD4+T cell infiltration and pro-inflammatory polarization exist in adipose tissue in type 2 diabetic ApoE−/− mice. T2DM ADSCs had impaired function in restricting CD4+T lymphocyte proliferation and pro-inflammatory polarization due to immune phenotypic changes.

The use of acoustic metamaterials with novel phenomena to design acoustic waveguides with special properties has obvious potential application value. Here, we propose a virtual soft boundary (VSB) model with high reflectivity and half cycle phase loss, which consists of an acoustic propagation layer and an acoustic metamaterial layer with tube arrays. Then the waveguide designed by the VSB is presented, and the numerical and experimental results show that it can separate acoustic waves at different frequencies without affecting the continuity and the flow of the medium in the space. The VSB waveguide can enrich the functions of acoustic waveguides and provide more application prospects.

An acoustic one-way device plays an important role in acoustic wave regulation. However, traditional one-way structures mainly discuss the unidirectional behavior of acoustic energy and often suffer from changes in mode or frequency. Here, we propose an acoustic one-way waveguide device with acoustic soft boundaries in which a special wave pattern filter is constructed. The numerical and experimental results show that acoustic waves can pass through the acoustic waveguide device efficiently in the positive direction without any wave pattern change and can be totally reflected back in the negative direction. The effective cascade of two one-way waveguide devices is also realized. Our work may provide a practical and efficient approach to the innovative design possibilities in the fields of acoustic wave regulation and computing devices.

The conductance enhancement of QH states propagating far from disordered edges is directly observed. Separate biasing of channels, and gate-controlled transmission to contacts is demonstrated., The formation of quantum Hall channels inside the bulk of graphene is studied using various contact and gate geometries. p–n junctions are created along the longitudinal direction of samples, and enhanced conductance is observed in the case of bipolar doping due to the new conducting channels formed in the bulk, whose position, propagating direction and, in one geometry, coupling to electrodes are determined by the gate-controlled filling factor across the device. This effect could be exploited to probe the behavior and interaction of quantum Hall channels protected against uncontrolled scattering at the edges.

We report the experimental observation of commensurability oscillations (COs) in 1D graphene superlattices. The widely tunable periodic potential modulation in hBN encapsulated graphene is generated via the interplay of nanopatterned few layer graphene acting as a local bottom gate and a global Si back gate. The longitudinal magneto-resistance shows pronounced COs, when the sample is tuned into the unipolar transport regime. We observe up to six CO minima, providing evidence for a long mean free path despite the potential modulation. Comparison to existing theories shows that small angle scattering is dominant in hBN/graphene/hBN heterostructures. We observe robust COs persisting to temperature exceeding $T=150$ K. At high temperatures, we find deviations from the predicted $T$-dependence, which we ascribe to electron-electron scattering., 6 pages, 4 figures + Supplemental Material. Accepted by PRL

Designing recycled concrete mixture proportion of different recycled coarse and fine aggregate replacement content by pulp content ,then testing compressive strength and splitting tensile strength. The text results show that: With the increasing of recycled aggregate content , the compressive strength and splitting tensile strength of recycled aggregate concrete trended to decrease. Compared to recycled coarse aggregate, recycled fine aggregate impact on the properties of recycled concrete is greater. Establishing the compressive strength and splitting tensile strength formula of recycled concrete based on a lot of experimental results.

ID3 algorithm is a classical algorithm in decision tree algorithm, commonly used in data mining. Owing to that spatial information data has the characteristics of large capacity and diversity, when ID3 algorithm does data mining for spatial information, in the process of generating decision tree, some nodes will appear special sample sets which the information gain of each classification attribute is 0 and values of result attribute are not unique in. Now, conventional implementation of ID3 algorithm can't ensure the generation of decision tree. Based on this, conventional implementation of ID3 algorithm is improved, and the fault tolerance of algorithm implementation is enhanced. Improved algorithm implementation can do data mining for spatial data set

Semaphorin-3E, provoking inflammation and insulin resistance which leads to metabolic syndrome, exerts obscure effects on carotid atherosclerosis in metabolic syndrome. The Tribbles 3 Q84R polymorphism is involved in insulin resistance. This study aims to investigate whether the Tribbles 3 Q84R polymorphism has profound effects on serum semaphorin 3E and what effect semaphorin 3E exerts on carotid atherosclerosis.A total of 518 unrelated Chinese subjects consisted of control (n=258) and metabolic syndrome (n=260) groups. Clinical and biochemical characteristics were collected. The level of serum semaphorin 3E was measured by enzyme-linked immunosorbent assay. Genotyping of the functional Tribbles 3 Q84R polymorphism was achieved by RFLP-PCR method. All subjects underwent carotid ultrasonography to determine carotid intima-media thickness (considered atherosclerosis if above 0.9 mm).Serum semaphorin 3E was significantly increased in metabolic syndrome (Individuals with metabolic syndrome demonstrated further increased serum semaphorin 3E, especially those with Tribbles 3 RR84 genotype. Increased serum semaphorin 3E may in part exacerbate insulin resistance and carotid atherosclerosis.

At high magnetic fields the conductance of graphene is governed by the half-integer quantum Hall effect. By local electrostatic gating a \textit{p-n} junction perpendicular to the graphene edges can be formed, along which quantum Hall channels co-propagate. It has been predicted by Tworzid\l{}o and co-workers that if only the lowest Landau level is filled on both sides of the junction, the conductance is determined by the valley (isospin) polarization at the edges and by the width of the flake. This effect remained hidden so far due to scattering between the channels co-propagating along the \textit{p-n} interface (equilibration). Here we investigate \textit{p-n} junctions in encapsulated graphene with a movable \textit{p-n} interface with which we are able to probe the edge-configuration of graphene flakes. We observe large quantum conductance oscillations on the order of \si{e^2/h} which solely depend on the \textit{p-n} junction position providing the first signature of isospin-defined conductance. Our experiments are underlined by quantum transport calculations., Comment: 5 pages, 4 figures

Objective: The objective of this study was to investigate the effects of Da-Cheng-Qi decoction (DCQD) on enteroparalysis and levels of the serum inflammatory cytokines C-C motif chemokine ligand 2 (CCL2) and interleukin-8 (IL-8) in patients with severe acute pancreatitis (SAP). Methods: A total of 48 patients diagnosed with SAP who hospitalized in First Affiliated Hospital of Henan Traditional Chinese Medicine University from May 1, 2016 to May 30, 2018 were randomly assigned to the control or treatment groups. Patients in the control group (n = 22) received conventional treatment and those in the treatment group (n = 26) received conventional treatment as well as additional DCQD for 10 days. The duration of abdominal pain and distension, the time when bowel sounds returned to normal, changes in the levels of serum amylase, lipase, C-reactive protein (CRP), CCL2 and IL-8, as well as acute physiology and chronic health evaluation (APACHE) II scores of patients on days 1 and 10 were recorded and compared. Results: The duration of abdominal pain and distension, the time when bowel sounds returned to normal, the levels of blood amylase, lipase and CRP, and APACHE II scores of patients in the treatment group decreased significantly compared with those of patients in the control group. Though there were no statistical differences in serum CCL2 and IL-8 concentrations on day 1 between patients in these two groups, the levels of serum CCL2 and IL-8 in the treatment group were lower than those in the control group on day 10. Conclusion: DCQD may decrease the levels of CCL2, CRP, and IL-8 in patients with SAP, quickly relieve enteroparalysis, and shorten hospitalization duration.

OBJECTIVES MiR-196a levels inversely correlated with survival in pancreatic adenocarcinoma patients. However, the functional contributions of miR-196a to pancreatic cancer remain unclear. METHODS Three lentiviral vectors encoding microRNA miR-196a precursor, inhibitor, and scrambled microRNA oligomer were transfected into Panc-1 cells, respectively. Then we explored the regulation of inhibitor of growth 5 (ING5) expression by miR-196a and its impact on apoptosis, invasion, and growth of pancreatic cancer cells. The lentiviral transfected Panc-1 cells were surgically implanted into the pancreas of mice. In vivo tumor growth and ING5 expression were measured. RESULTS Down-regulation of ING5 expression was detected in cells transfected with miR-196a precursor (P < 0.01), accompanied by less apoptosis, increased invasion, and proliferation compared with control cells (P < 0.05). Cells transfected with miR-196a inhibitor revealed an opposite trend. Smaller detectable tumors were found in only 60% of mice after implantation of Lenti.miR-196a inhibitor-transfected Panc-1 cells compared with controls (360.7 ± 303.6 mm vs 511.58 ± 365.9 mm in controls; P < 0.01). CONCLUSION Our results provide experimental evidence to support aberrant expression of miR-196a is associated with abnormal apoptosis, invasion, and proliferation of pancreatic cancer cells.

Atherosclerosis (AS) is the most common and serious complication of type 2 diabetes mellitus (T2DM) and is accelerated via chronic systemic inflammation rather than hyperglycemia. Adipose tissue is the major source of systemic inflammation in abnormal metabolic state. Pro-inflammatory CD4We constructed type 2 diabetic ApoECD4CD4

Cooperative games theory has been widely used in the solution of Multi-participant cost allocation problem. This paper reports on the application of Shapley Value to procedure of finding the optimal solution to cost allocation problem among local governments at various levels in China. Based on the analysis of relationship among vehicle flowrate in different segments of highway, we deduce the formula to find a stable solution and raise reasonable solutions to cost allocation of roll highway among various governments involved. Eventually we put forward proper proposals for central government considering its dominant function.

Effective control of the domain wall (DW) motion along the magnetic nanowires is of great importance for fundamental research and potential application in spintronic devices. In this work, a series of permalloy nanowires with an asymmetric notch in the middle were fabricated with only varying the width (d) of the right arm from 200 nm to 1000 nm. The detailed pinning and depinning processes of DWs in these nanowires have been studied by using focused magneto-optic Kerr effect (FMOKE) magnetometer, magnetic force microscopy (MFM) and micromagnetic simulation. The experimental results unambiguously exhibit the presence of a DW pinned at the notch in a typical sample with d equal to 500 nm. At a certain range of 200 nm d d dependences, which may be originated from different potential well/barrier generated by the asymmetric notch with varying d.

We report on the observation of magnetoresistance oscillations in graphene p-n junctions. The oscillations have been observed for six samples, consisting of single-layer and bilayer graphene, and persist up to temperatures of 30 K, where standard Shubnikov-de Haas oscillations are no longer discernible. The oscillatory magnetoresistance can be reproduced by tight-binding simulations. We attribute this phenomenon to the modulated densities of states in the n- and p-regions.

We report a broadband acoustic energy harvesting metasurface consisting of periodic arrangements of coupled Helmholtz resonators. Theoretical analysis and numerical and experimental results show that a high output voltage can be obtained at a wide band (460 Hz–680 Hz) under the push-pull effect on the piezoelectric composite sheet (PCS) between the two coupled cavities, which is because the acoustic pressure phases in the two coupled cavities are nearly opposite to each other. Each output can be directly connected in parallel without any rectification circuit because the output voltage from every PCS has the same phase on account of the symmetry of the proposed metasurface. The proposed design has an efficient and easy-to-integrate structure, and it can be used in broad applications for acoustic energy harvesting devices and acoustic insulators.

Software testing is an important technique to assure the quality of software systems, especially high-confidence systems. To automate the process of software testing, many automatic test-data generation techniques have been proposed. To generate effective test data, we propose a test-data generation technique guided by static defect detection in this paper. Using static defect detection analysis, our approach first identifies a set of suspicious statements which are likely to contain faults, then generates test data to cover these suspicious statements by converting the problem of test-data generation to the constraint satisfaction problem. We performed a case study to validate the effectiveness of our approach, and made a simple comparison with another test-data generation on-line tool, JUnit Factory. The results show that, compared with JUnit Factory, our approach generates fewer test data that are competitive on fault detection.

Artificial graphene consisting of honeycomb lattices other than the atomic layer of carbon has been shown to exhibit electronic properties similar to real graphene. Here, we reverse the argument to show that transport properties of real graphene can be captured by simulations using "theoretical artificial graphene." To prove this, we first derive a simple condition, along with its restrictions, to achieve band structure invariance for a scalable graphene lattice. We then present transport measurements for an ultraclean suspended single-layer graphene pn junction device, where ballistic transport features from complex Fabry-P\'erot interference (at zero magnetic field) to the quantum Hall effect (at unusually low field) are observed and are well reproduced by transport simulations based on properly scaled single-particle tight-binding models. Our findings indicate that transport simulations for graphene can be efficiently performed with a strongly reduced number of atomic sites, allowing for reliable predictions for electric properties of complex graphene devices. We demonstrate the capability of the model by applying it to predict so-far unexplored gate-defined conductance quantization in single-layer graphene., Comment: published version, with supplemental material

Chirality is one of the key features governing the electronic properties of single- and bilayer graphene: the basics of this concept and its consequences on transport are presented in this review. By breaking the inversion symmetry, a band gap can be opened in the band structures of both systems at the K-point. This leads to interesting consequences for the pseudospin and, therefore, for the chirality. These consequences can be accessed by investigating the evolution of the Berry phase in such systems. Experimental observations of Fabry-Perot interference in a dual-gated bilayer graphene device are finally presented and are used to illustrate the role played by the band gap on the evolution of the pseudospin. The presented results can be attributed to the breaking of the chirality in the energy range close to the gap., Comment: To be published in Physica Status Solidi (RRL) - Rapid Research Letters

This paper proposes a video retargeting method. The method makes multimedia more suitable for ubiquitous video access, including comfortable watching, interesting region detection and safety transmitting. Because of the rapid progress of electronic commercial product, video service needs to adapt different device. There are some challenges: First at all, the resolution, aspect ratio and size of display are different from the original video. Secondly, people do not have interesting on the whole movie. Based on face recognition, adaptive showing region function has been implemented. Some demonstrations are also presented.

This paper proposes an novel idea to develop application. Different from traditional programming methods, users can design their application without long term training. The tool prevents syntax and semantic errors during design the application. Based on the proposed idea a total solution to develop application for android system is established. The system includes a cloud system, user management system, web base development tool and an auto deploy system. By means of simply drag and drop, users can design and deploy their application. The architecture also provides flexibility to change the application target with modify the language layer.

We report on transport properties of monolayer graphene with a laterally modulated potential profile, employing striped top gate electrodes with spacings of 100 nm to 200 nm. Tuning of top and back gate voltages gives rise to local charge carrier density disparities, enabling the investigation of transport properties either in the unipolar (nn') or the bipolar (np') regime. In the latter pronounced single- and multibarrier Fabry-Perot (FP) resonances occur. We present measurements of different devices with different numbers of top gate stripes and spacings. The data are highly consistent with a phase coherent ballistic tight binding calculation and quantum capacitance model, whereas a superlattice effect and modification of band structure can be excluded., Comment: revised version

We report on the analysis of quantum transport through an Aharonov-Bohm ring with embedded double quantum dots. The normal metal leads are assumed to be weakly coupled to the two quantum dots. In the quantum dot region, Rashba spin-orbit coupling and electron-electron interaction are considered. The quantum transport is analyzed based on the Keldysh nonequilibrium Green's function formalism. A spin-polarized current emerges in this device due to the combined effect of a magnetic flux, threading through the AB ring, and the Rashba spin-orbit coupling. An interesting switching property of the spin polarization by turning on and off the gate within small voltage window is observed. This feature, however, does not exist in the Aharonov-Bohm ring structure with single quantum dot. We therefore propose a theoretical idea of a bipolar spin polarization switch