1. Human Dermal CD14+ Cells Are a Transient Population of Monocyte-Derived Macrophages
- Author
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McGovern, Naomi, Schlitzer, Andreas, Gunawan, Merry, Jardine, Laura, Shin, Amanda, Poyner, Elizabeth, Green, Kile, Dickinson, Rachel, Wang, Xiao-Nong, Low, Donovan, Best, Katie, Covins, Samuel, Milne, Paul, Pagan, Sarah, Aljefri, Khadija, Windebank, Martin, Miranda-Saavedra, Diego, Larbi, Anis, Wasan, Pavandip Singh, Duan, Kaibo, Poidinger, Michael, Bigley, Venetia, Ginhoux, Florent, Collin, Matthew, Haniffa, Muzlifah, McGovern, Naomi [0000-0001-5200-2698], and Apollo - University of Cambridge Repository
- Subjects
CD11b Antigen ,Macrophages ,T-Lymphocytes ,Receptors, IgG ,Immunology ,Lipopolysaccharide Receptors ,hemic and immune systems ,chemical and pharmacologic phenomena ,Cell Differentiation ,Mice, Transgenic ,Dendritic Cells ,Article ,Mice ,Infectious Diseases ,Cell Movement ,Animals ,Humans ,Immunology and Allergy ,Cell Lineage ,Female ,Immunologic Memory ,Cells, Cultured ,Skin - Abstract
Dendritic cells (DCs), monocytes, and macrophages are leukocytes with critical roles in immunity and tolerance. The DC network is evolutionarily conserved; the homologs of human tissue CD141(hi)XCR1⁺ CLEC9A⁺ DCs and CD1c⁺ DCs are murine CD103⁺ DCs and CD64⁻ CD11b⁺ DCs. In addition, human tissues also contain CD14⁺ cells, currently designated as DCs, with an as-yet unknown murine counterpart. Here we have demonstrated that human dermal CD14⁺ cells are a tissue-resident population of monocyte-derived macrophages with a short half-life of
- Published
- 2014
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