27 results on '"Mikhailidis D"'
Search Results
2. Ghrelin, obesity and atherosclerosis
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Sudar, E., Sanja Soskić, Zaric, B. L., Rasic-Milutinovic, Z., Smiljanic, K., Radak, D., Mikhailidis, D. P., Rizzo, M., and Isenovic, E. R.
3. Time for new indications for statins?
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Banach, M., Mikhailidis, D. P., Kjeldsen, S. E., and Jacek Rysz
4. The role of polyphenols in cardiovascular disease
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Michalska, M., Gluba, A., Mikhailidis, D. P., Piotr Nowak, Bielecka-Dabrowa, A., Rysz, J., and Banach, M.
5. Awareness, treatment and control of the metabolic syndrome and its components: A multicentre Greek study
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Vasilios Athyros, Ganotakis, E. S., Bathianaki, M., Monedas, I., Goudevenos, I. A., Papageorgiou, A. A., Papathanasiou, A., Kakafika, A. I., Mikhailidis, D. P., and Elisaf, M.
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Adult ,Male ,Cross-Sectional Studies ,Prevalence ,Greece/epidemiology ,Humans ,Female ,Metabolic Syndrome X/blood/diagnosis/*epidemiology/therapy ,Middle Aged ,Health Education - Abstract
INTRODUCTION: There are no data concerning the degree of awareness, treatment and control of the metabolic syndrome (MetS) and its components or associated vascular risk in the general population. METHODS: A cross-sectional analysis was made of a representative sample of Greek adults (n=9669, 49% men and 51% women), living in urban, semi-urban and rural areas (55%, 23% and 22%, respectively). The National Cholesterol Education Program (NCEP-ATP III) and the International Diabetes Federation (IDF) definitions for the MetS were used. RESULTS: The age-standardised prevalence of the MetS in the general population was 24.5% [95% CI 23.4-25.7%] (n=2369). This was similar in men and women and increased with age. Among subjects with the NCEP MetS the prevalence of hypertension was 71%, elevated blood glucose 55%, low high-density lipoprotein cholesterol 58%, high triglycerides 63% and abdominal obesity 82%. Only one third of subjects were aware of the MetS component conditions, less than one quarter were on treatment, and very few (< or =10%) were controlled for MetS components. Awareness of MetS individual component conditions (e.g. arterial hypertension), and consequently effective control, was lower than that reported in other cohorts, including subjects without MetS. Only 5% of subjects were aware of MetS as an entity, 2% were treated for all component conditions and only 1% were controlled. Using the IDF definition, the prevalence of MetS was higher (43.4%) and awareness, treatment and control of MetS and its components were significantly lower. CONCLUSIONS: The prevalence of MetS is high in Greece but is not recognised among the general population. Therefore, treatment and control of MetS and component conditions are extremely low. If the situation does not improve soon, MetS will cause a further increase in the vascular disease epidemic in the years to come. This calls for urgent education of the public and the medical community. Hellenic J Cardiol
6. Recent advances in the diagnosis and treatment of interstitial lung disease in systemic sclerosis (scleroderma): A review
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Tan, A., Denton, C. P., Mikhailidis, D. P., and Alexander seifalian
7. Intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 at the early stages of atherosclerosis in a rat model
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Fotis, L., Agrogiannis, G., Ioannis Vlachos, Pantopoulou, A., Margoni, A., Kostaki, M., Verikokos, C., Tzivras, D., Mikhailidis, D. P., and Perrea, D.
8. Increased risk of vascular events in systemic lupus erythematosus: Is arterial stiffness a predictor of vascular risk?
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Tziomalos, K., Sivanadarajah, N., Mikhailidis, D. P., Boumpas, D. T., and Alexander seifalian
9. Prothrombotic and lipoprotein variables in patients attending a cardiovascular risk management clinic: Response to ciprofibrate or lifestyle advice
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Mikhailidis, D. P., EMMANUEL GANOTAKIS, Spyropoulos, K. A., Jagroop, I. A., Byrne, D. J., and Winder, A. F.
10. Genetic determinants of cardiovascular disease: The renin-angiotensin- aldosterone system, paraoxonases, endothelin-1, nitric oxide synthase and adrenergic receptors
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Gluba, A., Banach, M., Mikhailidis, D. P., and Jacek Rysz
11. Regional differences in the expression of nitric oxide synthase and specific receptors in the vascular tissues of control and diabetic rabbits: A pilot study
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Alnaeb, M. E., Thompson, C. S., Alexander seifalian, Hamilton, G., and Mikhailidis, D. P.
12. European Society of Vascular Surgery (ESVS) guidelines. Invasive treatment for carotid stenosis: Indications, techniques | Wytyczne Europejskiego Towarzystwa Chirurgii Naczyniowej (ESVS). Leczenie inwazyjne zwȩżenia tȩtnicy szyjnej: Wskazania, metody postȩpowania
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Liapis, C. D., Bell, P. R. F., Mikhailidis, D., Sivenius, J., Nicolaides, A., Jose Fernandes e Fernandes, Biasi, G., and Norgren, L.
13. Natural products as the integral part of the therapy?
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Maciej Banach, Mikhailidis, D. P., Serban, M. -C, and Sahebkar, A.
14. Use of statins (multiple letters) [6]
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Enoch, P., Akehurst, R. L., Sheridan, P., Savege, P., Silverman, S., Bennett, W., Mcnee, W., Metcalfe, S., Wright, J. M., Wierzbicki, A. S., Reynolds, T. M., Maryon Davis, A., Mikhailidis, D. P., Winder, A. F., Mcmurray, J., Mcguire, A., Raikou, M., Morrison, C., Wakeman, A. P., Leach, R. H., Lewis, D., Wallis, E. J., Ramsay, L. E., Wilfred Yeo, Jackson, P. R., Pickin, M., Haq, I. U., Betteridge, J., Shepherd, J., Thompson, G., Kjekshus, J., and Pedersen, T. R.
15. Low-molecular-weight heparin during instability in coronary artery disease [14]
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Mikhailidis, D. P., Jagroop, I. A., Ganotakis, E., Knight, C. J., and Alison Goodall
16. Why the United States Center for Medicare and Medicaid Services (CMS) should not extend reimbursement indications for carotid artery angioplasty/stenting (International Angiology 31, 1 (85-89))
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Abbott, A. L., Adelman, M. A., Alexandrov, A. V., Barnett, H. J. M., Beard, J., Bell, P., Björck, M., Blacker, D., Buckley, C. J., Cambria, R. P., Comerota, A. J., Connolly, E. S., Davies, A. H., Eckstein, H. -H, Faruqi, R., Fraedrich, G., Gloviczki, P., Hankey, G. J., Harbaugh, R. E., Heldenberg, E., Kittner, S. J., Kleinig, T. J., Mikhailidis, D. P., Moore, W. S., Naylor, R., Nicolaides, A., Kosmas I. Paraskevas, Pelz, D. M., Prichard, J. W., Purdie, G., Ricco, J. -B, Riles, T., Rothwell, P., Sandercock, P., Sillesen, H., Spence, J. D., Spinelli, F., Tan, A., Thapar, A., Veith, F. J., and Zhou, W.
17. Atrial fibrillation as a nonpsychiatric predictor of delirium after cardiac surgery: A pilot study
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Maciej Banach, Kazmierski, J., Kowman, M., Okonski, P., Sobow, T., Kloszewska, I., Mikhailidis, D. P., Goch, A., Banys, A., Rysz, J., Goch, J. H., and Jaszewski, R.
18. Chronic hind limb ischemia reduces myocardial ischemia-reperfusion injury in the rabbit heart by promoting coronary angiogenesis/arteriogenesis
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Varnavas, V. C., Kosmas I. Paraskevas, Iliodromitis, E. K., Zoga, A., Glava, I., Kaklamanis, L., Spartinos, J., Lyras, T., Kremastinos, D. T., Mikhailidis, D. P., and Kyriakides, Z. S.
19. The significance of statin use in patients subjected to surgical coronary revascularization
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Maciej Banach, Mikhailidis, D. P., Ugurlucan, M., Barylski, M., Banyś, A., Goch, A., and Goch, J. H.
20. 40 EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004
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Veitenhansl, M., Stegner, K., Hierl, F-X, Dieterle, C., Feldmeier, H., Gutt, B., Landgraf, R., Garrow, A. P., Vileikyte, L., Findlow, A., Waterman, C., Boulton, A. J. M., Shankhdhar, K., Shankhdhar, L., Shankhdhar, U., Petrova, N. L., Foster, A. V. M., Edmonds, M. E., Ferraresi, R., Caravaggi, C., Giglio, R., Cavaiani, P., Pogliaghi, I., Sommariva, E., Katz, I. A., Harlan, A., Miranda-Palma, B., Prieto-Sanchez, L., Armstrong, D. G., Bowker, J. H., Mizel, M. S., Cernea, S., Wohlgelernter, J., Kidron, M., Modi, P., Raz, I., Arbit, E., Nosek, L., Kapitza, C., Beckett, P., Gelfand, R., Goldberg, M., Heise, T., Testa, M. A., Turner, R. R., Hayes, J. F., Scranton, R. E., Simonson, D. C., Yang, Y-W, Hsu, Y-J, Naujok, O., Francini, F., Jorns, A., Tiedge, M., Lenzen, S., Abdel-Wahab, Y. H. A., Marenah, L., Orr, D. F., Shaw, C., Flatt, P. R., Chokkalingam, K., Mansell, P. I., Clausen, P., Ekbom, P., Damm, P., Feldt-Rasmussen, U., Nielsen, B., Mathiesen, E. R., Feldt-Rasmussen, B., Dewan, S., Da Silva, N., Ternan, P. Mc, Leong, K. S., Wilding, J. P. H., Asatiani, N., Kurashvili, R., Dundua, M., Shelestova, E., Pagava, K., Ramazashvili, M., Hod, M., Smirnov, S., Petersen, J. L. A., Justesen, T. I., Ringholm Nielsen, L., Muller, C., Hojlund, K., Wensaas, A., Kase, E. T., Aas, V., Rustan, A. C., Thoresen, G. H., Levin, K., Beck-Nielsen, H., Gaster, M., Im, S-S, Kang, S-Y, Kim, S-Y, Ahn, Y-H, Lihn, A. S., Schmoll, D., Werner, T., Kienitz, A., Meyer, M., Barthel, A., Ailett, F., Sutherland, C., Walther, R., Grempler, R., Sasson, S., Reich, R., Tenenbaum, T., Alpert, E., Anfossi, G., Russo, I., Traversa, M., Massucco, P., Mattiello, L., Doronzo, G., Trovati, M., Lally, S., Tan, C. Y., Owens, D., Tomkin, G. H., Porchay, I., Pean, F., Bellili, N., Betoulle, D., Balkau, B., Tichet, J., Marre, M., Fumeron, F., Group D.E.S.I.R., Chatellier, G., Alhenc-Gelas, F., Diabhycar, Study Group, Nichols, G. A., Brown, J. B., Hayes, R. P., Bowman, L., Drexel, H., Saely, C. H., Marte, T., Benzer, W., Langer, P., Hoefle, G., Moll, W., Aczel, S., Karagiannis, E., Lubben, G., Urquhart, R., Edwards, G., Bruce, S., Howlett, H. S. C., Cugnardey, N., Turner, K. C., Park, J-S, Fiedorek, F. T., Avogaro, A., Gallo, A., Pinton, P., Rizzuto, R., Murphy, E., Ceolotto, G., Caterson, I., Guy-Grand, B., Hill, J., Barone, M., Aiello, A., Allochis, G., Borzi, V., Cannata, F., Caronna, S., D Avanzo, A., Elli, R., Formoso, G., Paroli, A., Scardapane, R., Sorichetti, P., Tatti, P., Viviani, G., Santeusanio, F., Italian Repaglinide Study Group, Manzella, D., Grella, R., Abbatecola, A. M., Paolisso, G., Sondergaard, L. G., Monster, T. B. M., Johnsen, S. P., Olsen, M. L., Mclaughlin, J. K., Sorensen, H. T., Lervang, H. H., Rungby, J., Lyssenko, V., Fredriksson, J., Almgren, P., Anevski, D., Orho-Melander, M., Sjogren, M., Tuomi, T., Groop, L., Jaziri, R., Aubert, R., Tuomilehto, J., Hu, G., Jousilahti, P., Peltonen, M., Lindstrom, J., Laina, A., Alevizaki, M., Philippou, G., Souvatzoglou, A., Anastasiou, E., Alba, S., Metcalf, B. S., Voss, L. D., Jeffery, A. N., Wilkin, T. J., Gluimer, C., Colagiuri, S., Vistisen, D., Borch-Johnsen, K., Haynes, A., Bower, C., Bulsara, M. K., Jones, T. W., Davis, E. A., Mortensen, H. B., Hougaard, P., Holl, R., Swift, P., Pociot, F., Knip, M., Hansen, L., Szadkowska, A., Pietrzak, I., Zmyslowska, A., Wyka, K., Bodalski, J., Holl, R. W., Swift, R., Hougaard, R., Gerstl, E-M, Engelsberger, I., Rabl, W., Rosenbauer, J., Grobe, H., Hofer, S. E., Krause, U., DPV-Wiss-Study Group, Dabelea, D., Morgan, T., Pettitt, D. J., Dolan, L., Mayer-Davis, E. J., Pihoker, C., Hillier, T. A., Imperatore, G., Ruggiero, A., Hamman, R. E., Stylianou, A., Tentolouris, N., Perrea, D., Tselepis, A. D., Lourida, E., Kitsou, E., Katsilambros, N., Vedovato, M., Dodesini, A. R., Lepore, G., Tiengo, A., Trevisan, R., Penno, G., Miccoli, R., Pucci, L., Lucchesi, D., Bandinelli, S., Fotino, C., Triscornia, S., Baldassari, E., Del Prato, S., Reboldi, P., Santeusanio, E., Fuller, J., Langham, R. G., Gow, R. M., Zhang, Y., Kelly, D. J., Christensen, P. K., Parving, H-H, Gilbert, R. E., Chibalin, A. V., Zhong, Z., Kotova, O., Davidescu, A., Ehren, I., Ekberg, K., Wahren, J., Wassef, L., Buckley, A. J., Rooney, K. B., Briody, J., Thompson, M., Ozanne, S. E., Thompson, C. H., Chamson-Reig, A., Summers, K., Arany, E. J. R., Hill, D. J., Solerte, S. B., Gazzaruso, C., Locatelli, E., Precerutti, S., Schifino, N., Ferrari, E., Fioravanti, M., Phenekos, C. V., Ginis, A., Fragaki, I., Chalkiadaki, M., Tzioras, C., Powell, L. A., Mcguire, G. M., Jewhurst, V., Trimble, E. R., Rasmussen, B. M., Vessby, B., Uusitupa, M., Berglund, L., Pedersen, E., Riccardi, G., Rivellese, A. A., Tapsell, L., Hermansen, K., Kanwu, Study Group, Da Silva Xavier, G., Rutter, J., Rutter, G. A., Briaud, I. M., Lingohr, M. K., Dickson, L. M., Mccuaig, J. R., Lawrence, J. C., Rhodes, C. J., Wikstrom, J. D., Katzman, S. M., Shirihai, O. S., Yang, J., Deng, S., Wang, X., Hessner, M. J., Wu, J., Wong, R. K., Sukumvanich, S., Markman, J. F., Naji, A., Wolf, B. A., Gao, Z., Rubi, B., Del Arco, A., Satrustegui, J., Maechler, P., Del Guerra, S., Lupi, R., Bugliani, M., Sbrana, S., Torri, S., Boggi, U., Vistoli, F., Mosca, F., Marchetti, P., Rennings, A. J. M., Smits, P., Stewart, M. W., Tack, C. J. J., Li, L., Nystrom, T., Gutniak, M., Ahren, B., Holst, J., Sjoholm, A., Gomes, M. B., Cailleaux, S., Tibirica, E., Albertini, J-P, Chen, H., Mather, R., Valensi, P. E., Chisalita, S. I., Arnqvist, H. J., Kraenkel, N., Adams, V., Linke, A., Gielen, S., Schuler, G., Humbrecht, R., Cipollone, F., Iezzi, A., Fazia, M., Pini, B., Cucurullo, C., Cesare, D., Schmidt, A. M., Mazurek, T., Zang, L. F., Mannion, J., Diehl, J., Martin, J., Martella, A., Zalewski, A., Shi, Y., Otter, W., Winter, M., Doering, W., Standi, E., Schnell, O., Kragelund, C., Kober, L., Faber, J., Hildebrandt, P., Steffensen, R., Pankowska, E., Szypowska, A., Lipka, M., Herwig, J., Scholl-Schilling, G., Bohles, H., Robertson, K. J., Schonle, E., Gucev, Z., Mordhorst, L., Tamer, S. C., Gall, M-A, Ludvigsson, J., Hoogma, R. P. L., Hammond, P. J., Gomis, R., Kerr, D., Bruttomesso, D., Bouter, P., Wiefels, K. J., La Calle, H., Schweitzer, D. H., Pfohl, M., Torlone, E., Krinelke, L. G., 205-Nations Study Group, Conget, I., Storms, F., Rodriguez, J., Leperlier, C., Davies, M., At Lantus, Study Group, Peter, R., Luzio, S. D., Dunseath, G., Miles, A., Hare, B., Backx, K., Pauvaday, V., Owens, D. R., Caselli, A., Marfia, G. A., Battista, C., Veves, A., Spallone, V., Uccioli, L., Gonzalez, J. S., Peyrot, M. F., Rubin, R. R., Leventhal, H., Scheffler, N., Ulbrecht, J. S., Cavanagh, P. R., Boulton, A. J., Perrin, N. A., Oglesby, A., Bastyr, E. J., Ziegler, D., Siekierka-Kleiser, E., Meyer, B., Schweers, M., Selvarajah, D., Wilkinson, I. D., Emery, C. J., Shaw, P. J., Griffiths, P. D., Tesfaye, S., Obrosova, I. G., Arezzo, J., Phillips, K., Fidarestat Study Group, Gribble, F. M., Williams, L., Reimann, F., Iakoubov, R., Whiteside, C., Brubaker, P. L., Acitores, A., Gonzalez, N., Sancho, V., Valverde, I., Villanueva-Penacarrillo, M. L., Martin-Duce, A., Trigo, M. V., Arnes, L., Burkart, V., Ichino, N., Ohashi, A., Klein, B. S., Paxian, S., Schmid, R., Karlsen, A. E., Heding, P. E., Frobose, H., Ronn, S. G., Kruhoffer, M., Orntoft, T. F., Nerup, J., Mandrup-Poulsen, T., Billestrup, N., Cardozo, A. K., Ortis, F., Feng, Y-M, Rasschaert, J., Eylen, F., Storling, J., Herchuelz, A., Eizirik, D. L., Wang, H., Kouri, G., Wollheim, C. B., Ribaux, P., Hammar, E., Parnaud, G., Rouiller, D., Bosco, D., Halban, P., Midthjell, K., Carlsson, S., Grill, V., Lau, C., Farch, K., Glumer, C., Tetens, I., Jorgensen, T., Tillin, T., Forouhi, N., Mckeigue, P., Chaturvedi, N., Zethelius, B., Hales, C. N., Berne, C., Coleman, R. L., Stevens, R. J., Holman, R. R., Christensen, J. O., Sandbak, A., Lauritzen, T., Irwin, N., Gault, V. A., Green, B. D., Harriott, P., O Harte, F. P. M., Bouman, S. D., Urso, B., Brand, C. L., Rolin, B., Ribel, U., Schaffer, L., Maggs, D. G., Ceriello, A., Frias, J. P., Wang, Y., Ruggles, J. A., Kolterman, O. G., Piconi, L., Weyer, C., Want, L. L., Ratner, R. E., Uwaifo, G. I., Thornberry, N. A., Eiermann, G., Kim, D., Lankas, G., Leiting, B., Li, Z., Lyons, K., Petrov, A., Sinha Roy, R., Woods, A., Woods, J., Zhang, B. B., Fisher, M., Moller, D. E., Weber, A. E., Dreyer, M., Bellin, C., Schmitz, V., Roesen, R., Nescheret, A. P., Bose, A. K., Mocanu, M. M., Carr, R. D., Yellon, D. M., Manolopoulos, K., Born, S., Wagner, A., Jeziorska, M., Ben Drief, A., Bashir, M., Tomlinson, D., Malik, R. A., Zeymer, U., Schwarzmaier-D Assie, A., Petzinna, D., Chiasson, J-L, Stratton, I. M., Af Bjorkesten, C-G, Fagerudd, J., Rosengard-Barlund, M., Forsblom, C., Pettersson-Fernholm, K., Waden, J., Saraheimo, M., Ronnback, M., Thorn, L., Groop, P-H, Mollsten, A., Svensson, M., Kockum, I., Rudberg, S., Brismar, K., Dahlquist, G., Hovind, P., Hansen, T. K., Tarnow, L., Thiel, S., Jensen, B. R., Flyvbjerg, A., Kankova, K., Hertlova, M., Krusova, D., Schwenke, S., Ott, J., Thom, S. A. M., Mistry, P., Sjolie, A., Larsen, B., Witt, N., Hughes, A. D., Samira, H. H., Lahiry, S., Howlader, S. R., Parveen, S., Azad Khan, A. K., Clarke, P. M., Gray, A., Stevens, R., Holman, R., Phillips, L., Phillips, P. J., Chittleborough, C., Baldock, K., Taylor, A., North West Adelaide Health Study Team, Davis, W. A., Davis, T. M. E., Knuiman, M. W., Hendrie, D., Worthley, D., Nicolucci, A., Pellegrini, F., Berardis, G., Franciosi, M., Belfiglio, M., Rossi, M. C. E., Sacco, M., Valentini, M., Richardson, C. C., Jones, P., Persaud, S., Hussain, K., Clark, A., Christie, M. R., Gniuli, D., Hribal, M. L., Accili, D., Khan, M., Zervou, S., Cheung, L., Abouna, S., Ifandi, V., Pelengaris, S., Luco, R. F., Ferrer, J., Ma, D., Shield, J. P. H., Dean, W., Leclerc, I., Knauf, C., Burcelin, R., Kelsey, G., Powers, A. C., Shostak, A., Ferrara, N., Poffenberger, G., Jerome, W. G., Brissova, M., Geloneze, S. R., Tambascia, M. A., Pareja, J. C., Chaim, E., Silveira, H. V., Geloneze, B., Ravikumar, B., Carey, P. E., Snaar, J. E., Dheelchand, D., Cook, D. B., Neely, D., Taylor, G., Morris, P. G., Taylor, R., Stears, A. J., Masding, M. G., Wootton, S. A., Sandeman, D. D., Klimes, I., Wein, S., Gasperikova, D., Ukropec, J., Wiernsperger, N., Sebokova, E., Manco, M., Mingrone, G., Granato, L., Greco, A. V., Nanni, G., Castagneto, M., Vidal, H., Calvani, M., Ferrannini, E., Alvarsson, M., Sundkvist, G., Lager, I., Henricsson, M., Berntorp, K., Fernqvist-Forbes, E., Steen, L., Orn, T., Shutler, S., Bianchi-Biscay, M., Rosenstock, J., Sugimoto, D., Strange, P., Stewart, J., Soltes Rak, E., Dailey, G., Kloos, C., Muller, U., Samann, A., Femerling, M., Risse, A., Jecht, M., Haak, T., Garg, R., Lawrence, I. G., Akinsola, M. O., Davies, M. J., Mcnally, P. G., Garber, A. J., Kim, H., Draeger, E., Aydin, L., Sengul, A., Kurklu, A., Ucak, S., Basat, O., Seber, S., Altuntas, Y., Jin, J., Yu, Y., Yu, H., Zhang, X., Mattoo, V., Eckland, D., Widel, M., Duran, S., Fajardo, C., Strand, J., Knight, D., Oakley, D., Tan, M., Sato, A., Nagao, M., Aki, N., Nakagami, T., Iwamoto, Y., Zhou, Z., Li, X., Huang, G., Yan, X., Yang, L., Peng, J., Wang, J., Tan, S., Tang, W., Furnsinn, C., Brunmair, B., Wagner, L., Gras, F., Artwohl, M., Zierhut, B., Waldhausl, W., Shine, B. L., Hopkins, D., Anand, V., Lim, E., Raval, U., Sharp, P., Corder, R., Lipkin, D., Lahiri, A., Bartnik, M., Ryden, L., Ferrari, R., Malmberg, K., Pyorala, K., Simoons, M. L., Standl, E., Soler-Soler, J., Ohrvik, J., Euro Heart Survey Investigators, Bruce, D. G., Starkstein, S. E., Schauer, U. J. W., Astrup, A. S., Pietraszek, L., Nielsen, F. S., Rossing, P., Ali, S., Smidt, U. M., Yokoyama, H., Pavkov, M. E., Knowler, W. C., Bennett, P. H., Nelson, R. G., Lopez-Alba, A., Morcillo, L., Caballero, A., Montoya, L., Jimenez, A., Maceira, B., Lewis, J. B., Ravid, M., Wajman, A., Tadgell, C., Remuzzi, G., Hunsicker, L. G., Wessman, M., Taskinen, M-R, FinnDiane Study Group, Pugliese, G., Amadio, L., Menini, S., Oddi, G., Ricci, C., Iacobini, C., Pricci, F., Sorcini, M., Pesce, C., Migliaccio, E., Giorgio, M., Pelicci, P., Di Mario, U., Lassila, M., Jandeleit-Dahm, K., Seah, K. K., Calkin, A. C., Allen, T. J., Cooper, M. E., Lopes Faria, J. M., Cavakcanti, T. C., Silva, K. C., Ferrari, A. 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21. Targets for low-density lipoprotein cholesterol levels in patients with stable coronary heart disease: Where are we now after the 'treating to new targets' (TNT) trial?
- Author
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Liberopoulos, E. N., Vasilios Athyros, Elisaf, M. S., and Mikhailidis, D. P.
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Treatment Outcome ,Coronary Disease/*blood/prevention & control ,Pyrroles/therapeutic use ,Lipoproteins, LDL/*blood/drug effects ,Anticholesteremic Agents/*therapeutic use ,Humans ,Drug Therapy, Combination ,Randomized Controlled Trials as Topic/methods ,Heptanoic Acids/therapeutic use ,Azetidines/therapeutic use - Abstract
Hellenic J Cardiol
22. The in vitro effect of a low molecular weight heparin, nadroparin (Fraxiparine), on leukocytes obtained from patients with vascular disease
- Author
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Monica Neagu, Manda, G., Constantin, C., Tanaseanu, C., and Mikhailidis, D. P.
- Subjects
Peripheral Vascular Diseases ,Dose-Response Relationship, Drug ,Neutrophils ,Romania ,Leukocytes ,Myocardial Infarction ,Anticoagulants ,Humans ,Nadroparin ,Lymphocytes ,Aged ,Aortic Aneurysm, Abdominal - Abstract
Both lymphocytes and granulocytes may play a role in the immune system-mediated inflammatory response associated with non-Q wave infarction and aortic aneurysms.The purpose of this study was to establish the in vitro effects of a low molecular weight heparin (LMWH), nadroparin (Fraxiparine), on some functional parameters of peripheral granulocytes and lymphocytes isolated from control subjects and patients with aortic aneurysm or non-Q wave infarction.Nadroparin (0.06-600 AXaU/ml) exerted different in vitro effects on granulocytes and lymphocytes isolated from normal subjects and the patient groups. The following indices were assessed: superoxide anion release, lymphocyte proliferation, phagocytic activity and the cellular respiratory burst. The effects of nadroparin varied according to the patient group and the index of lymphocyte/granulocyte assessed.Since peripheral granulocytes isolated from these patients are activated, the observed inhibition exerted by nadroparin on superoxide anion release may be beneficial. LMWHs have additional effects that are independent of their anticoagulant activity. These effects may influence the "inflammatory component" of the atherosclerotic process.
23. The effect of bergamot on dyslipidemia
- Author
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Dimitri P. Mikhailidis, Angelo Maria Patti, Giuseppe Montalto, Rosaria Vincenza Giglio, Khalid Al-Rasadi, Niki Katsiki, Ekaterina A. Ivanova, Alexander N. Orekhov, Dragana Nikolic, Manfredi Rizzo, Giovanni Li Volti, Giglio, R., Patti, A., Nikolic, D., Li Volti, G., Al-Rasadi, K., Katsiki, N., Mikhailidis, D., Montalto, G., Ivanova, E., Orekhov, A., and Rizzo, M.
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Citrus ,Future studies ,Bergamot ,Pharmaceutical Science ,030204 cardiovascular system & hematology ,Bioinformatics ,01 natural sciences ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Nutraceutical ,Drug Discovery ,medicine ,Animals ,Humans ,Adverse effect ,Dyslipidemias ,Hypolipidemic Agents ,Flavonoids ,Pharmacology ,Plant Extracts ,Chemistry ,Cholesterol ,Medicine (all) ,Drug Discovery3003 Pharmaceutical Science ,Cardiovascular risk ,Complementary and Alternative Medicine2708 Dermatology ,medicine.disease ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Dyslipidemia ,Complementary and alternative medicine ,Biochemistry ,LDL cholesterol ,Citrus bergamia ,Molecular Medicine ,Narrative review ,Lipid lowering - Abstract
Background Statins are the most common used lipid lowering drugs but they may cause adverse effects and despite their well-established therapeutic benefits residual cardiovascular (CV) risk remains. The use of other lipid lowering drugs and nutraceuticals alone or as add-on lipid-modifying therapy can be an option in such cases. Several studies have reported health-related properties of the Citrus fruits, among which bergamot (Citrus bergamia Risso) differs from others by particularly high content of certain compounds. Purpose This narrative review summarizes the current evidence on the effects of bergamot on lipid parameters based on studies involving animals and humans. Main evidence This natural supplement may lead to effective lipid-lowering treatment. Its lipid-lowering activity is attributed to different flavonoids. However, the exact mechanisms involved remain unclear. Conclusion It is expected that ongoing and future studies will confirm the benefit of bergamot in dyslipidemic and other cardiometabolic disorders, potentially leading to reduced overall CV risk.
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- 2016
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24. An evaluation of RVX-208 for the treatment of atherosclerosis
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Dimitri P. Mikhailidis, Maciej Banach, Manfredi Rizzo, Norman C.W. Wong, Dragana Nikolic, Nikolic, D., Rizzo, M., Mikhailidis, D., Wong, N., and Banach, M.
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medicine.medical_specialty ,Apolipoprotein B ,apolipoprotein A-I ,RVX 208 ,high-density lipoprotein ,Pharmacology ,Epigenesis, Genetic ,chemistry.chemical_compound ,atherosclerosi ,High-density lipoprotein ,Metabolic Diseases ,Internal medicine ,medicine ,Animals ,Humans ,Pharmacology (medical) ,Quinazolinones ,biology ,Animal ,Cholesterol ,Medicine (all) ,Cholesterol, HDL ,Reverse cholesterol transport ,RVX-208 ,Quinazoline ,General Medicine ,Atherosclerosis ,Plaque, Atherosclerotic ,Metabolic Disease ,Bromodomain ,Orally active ,Endocrinology ,high-density lipoprotein particle ,chemistry ,Quinazolines ,biology.protein ,lipids (amino acids, peptides, and proteins) ,Human ,Lipoprotein - Abstract
Introduction: RVX-208 is a first-in-class, orally active, novel small molecule in development by Resverlogix Corporation (Calgary, AB, Canada). It acts through an epigenetic mechanism by inhibiting the bromodomain and extraterminal (BET) family of proteins, increasing apolipoprotein A-I (apoA-I) and targeting high-density lipoprotein (HDL) metabolism, including generating of nascent HDL and increased larger HDL particles, resulting in the stimulation of reverse cholesterol transport. RVX-208 also has a beneficial effect on inflammatory factors known to be involved in atherosclerosis and plaque stability. New therapeutic strategies are needed for patients with atherosclerosis.Areas covered: In this review, the authors evaluate the use of RVX-208 as an agent for the treatment of atherosclerosis. The article is based on a literature search considering both animal and human studies available on PubMed as well as Media Releases from the Resverlogix Corporation.Expert opinion: The current evidence suggests promising beneficial effects of this novel drug in the prevention and treatment of atherosclerosis and other metabolic disorders. Its unique mechanism of action is encouraging; it affects several pathways and has a modest effect on HDL levels. There is also a shift in particle size to larger HDL particles, which may have potent atheroprotective effects. Future clinical development is needed, including safety assessment.
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- 2015
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25. Peroxisome Proliferator-Activated Receptors and Atherosclerosis
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Božidarka L. Zarić, Srđjan Đ Stojanović, Dimitri P. Mikhailidis, Dragana Nikolic, Esma R. Isenovic, Sanja Soskic, Branislava Dobutovic, Edita Stokic, Milan Obradovic, Emina Sudar, Soskić, S., Dobutović, B., Sudar, E., Obradović, M., Nikolić, D., Zarić, B., Stojanović, S., Stokić, E., Mikhailidis, D., and Isenović, E.
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peroxisome proliferator-activated receptors gamma ,Peroxisome proliferator-activated receptor gamma ,medicine.medical_specialty ,Peroxisome Proliferator-Activated Receptors ,peroxisome proliferator-activated receptors alpha ,Inflammation ,atherosclerotic plaque ,030204 cardiovascular system & hematology ,03 medical and health sciences ,atherosclerosi ,0302 clinical medicine ,Internal medicine ,Humans ,Medicine ,Receptor ,Hypolipidemic Agents ,030304 developmental biology ,0303 health sciences ,business.industry ,Fibric Acids ,peroxisome proliferator-activated receptors γ ,Lipid metabolism ,Peroxisome ,Atherosclerosis ,Lipid Metabolism ,peroxisome proliferator-activated receptors α ,3. Good health ,Endocrinology ,Nuclear receptor ,Cancer research ,lipids (amino acids, peptides, and proteins) ,Peroxisome proliferator-activated receptor alpha ,atherosclerosis ,medicine.symptom ,Signal transduction ,Cardiology and Cardiovascular Medicine ,business ,Signal Transduction - Abstract
The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPARα, -γ, and -δ/β, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, which might present new approaches involved in the antiatherosclerotic effects revealed in this review. In addition, in this review we are presenting latest data from recent performed clinical studies which have focus on novel approach to PPARs agonists as potential therapeutic agents in the treatment of complex disease such as atherosclerosis. © SAGE Publications 2011.
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- 2011
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26. ESVS Guidelines: Section A--prevention in patients with carotid stenosis
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Liapis, CD, Bell, PF, Mikhailidis, DP, Sivenius, J, Nicolaides, A, Fernandes e. Fernandes, J, Norgren, L, Avgerinos, ED, Becker, F, Benedetti Valentini, F, Bequemin, JP, Diener, HC, Gaines, PA, Gensini, G, Gerotziafas, G, Griffin, M, Hacke, W, Heikkinen, MA, Norrving, B, Powell, J, Kakisis, J, Karkos, C, Konstantinidis, K, Kotsis, T, Mätzsch, T, Parsson, H, Pedro, LM, Salenius, JP, Schachter, M, Sillesen, H, Thomas, DJ, BIASI, GIORGIO MARIA, FROIO, ALBERTO, LAVITRANO, MARIALUISA, Liapis, C, Bell, P, Mikhailidis, D, Sivenius, J, Nicolaides, A, Fernandes e. Fernandes, J, Biasi, G, Norgren, L, Avgerinos, E, Becker, F, Benedetti Valentini, F, Bequemin, J, Diener, H, Froio, A, Gaines, P, Gensini, G, Gerotziafas, G, Griffin, M, Hacke, W, Heikkinen, M, Norrving, B, Powell, J, Kakisis, J, Karkos, C, Konstantinidis, K, Kotsis, T, Lavitrano, M, Mätzsch, T, Parsson, H, Pedro, L, Salenius, J, Schachter, M, Sillesen, H, and Thomas, D
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Adult ,medicine.medical_specialty ,Placebo-controlled study ,Carotid Stenosi ,law.invention ,Randomized controlled trial ,law ,Risk Factors ,Carotid artery disease ,Internal medicine ,medicine ,Humans ,Carotid Stenosis ,cardiovascular diseases ,Antihypertensive Agents ,Hypolipidemic Agents ,Pharmacology ,Hypolipidemic Agent ,biology ,business.industry ,Platelet Aggregation Inhibitor ,Risk Factor ,Contraindications ,C-reactive protein ,Cholesterol, LDL ,Vascular surgery ,medicine.disease ,Clinical trial ,Stenosis ,Antihypertensive Agent ,Cerebrovascular Disorders ,Cerebrovascular Disorder ,Cardiology ,biology.protein ,Platelet aggregation inhibitor ,Drug Therapy, Combination ,Drug Monitoring ,Cardiology and Cardiovascular Medicine ,business ,Platelet Aggregation Inhibitors - Abstract
Herein, we present the European Society for Vascular Surgery Guidelines pertinent to the secondary prevention of cerebrovascular events in patients with carotid artery stenosis including lipid lowering therapy, antiplatelet therapy and other risk factor modification. These recommendations are based on current evidence from clinical trials. There is a need for aggressive prevention treatment in patients with carotid artery disease. We also discuss the diagnosis and grading of carotid artery stenosis.
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- 2010
27. ESVS Guidelines: Section B - diagnosis and investigation of patients with carotid stenosis
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Liapis, CD, Bell, PF, Mikhailidis, DP, Sivenius, J, Nicolaides, A, Fernandes e. Fernandes, J, Norgren, L, Avgerinos, ED, Becker, F, Benedetti Valentini, F, Bequemin, JP, Diener, HC, Gaines, PA, Gensini, G, Gerotziafas, G, Griffin, M, Hacke, W, Heikkinen, MA, Norrving, B, Powell, J, Kakisis, J, Karkos, C, Konstantinidis, K, Kotsis, T, Mätzsch, T, Parsson, H, Pedro, LM, Salenius, JP, Schachter, M, Sillesen, H, Thomas, DJ, BIASI, GIORGIO MARIA, FROIO, ALBERTO, LAVITRANO, MARIALUISA, Liapis, C, Bell, P, Mikhailidis, D, Sivenius, J, Nicolaides, A, Fernandes e. Fernandes, J, Biasi, G, Norgren, L, Avgerinos, E, Becker, F, Benedetti Valentini, F, Bequemin, J, Diener, H, Froio, A, Gaines, P, Gensini, G, Gerotziafas, G, Griffin, M, Hacke, W, Heikkinen, M, Norrving, B, Powell, J, Kakisis, J, Karkos, C, Konstantinidis, K, Kotsis, T, Lavitrano, M, Mätzsch, T, Parsson, H, Pedro, L, Salenius, J, Schachter, M, Sillesen, H, and Thomas, D
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medicine.medical_specialty ,Ultrasonography, Doppler, Transcranial ,Carotid Stenosi ,Embolism, Fat ,Severity of Illness Index ,Diagnosis, Differential ,Internal medicine ,Carotid artery disease ,medicine ,Humans ,Carotid Stenosis ,cardiovascular diseases ,Pharmacology ,medicine.diagnostic_test ,business.industry ,Angiography ,Digital subtraction angiography ,Vascular surgery ,medicine.disease ,Plaque, Atherosclerotic ,Clinical trial ,Stenosis ,Embolism ,Research Design ,Cardiology ,Radiology ,Differential diagnosis ,Cardiology and Cardiovascular Medicine ,business - Abstract
Herein, we present the European Society for Vascular Surgery Guidelines pertinent to the secondary prevention of cerebrovascular events in patients with carotid artery stenosis including lipid lowering therapy, antiplatelet therapy and other risk factor modification. These recommendations are based on current evidence from clinical trials. There is a need for aggressive prevention treatment in patients with carotid artery disease. We also discuss the diagnosis and grading of carotid artery stenosis.
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- 2010
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