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1. Does endoscopic retrograde cholangiopancreatography reduce the risk of local pancreatic complications in acute pancreatitis? A systematic review and metaanalysis

Author

Maxim S. Petrov, Mikhail V. Kukosh, and Antonina F. Uchugina

Subjects
Cholangiopancreatography, Endoscopic Retrograde, Risk, medicine.medical_specialty, Endoscopic retrograde cholangiopancreatography, Pancreatic disease, medicine.diagnostic_test, business.industry, medicine.disease, Gastroenterology, law.invention, Postoperative Complications, Pancreatitis, Randomized controlled trial, law, Relative risk, Internal medicine, Meta-analysis, medicine, Humans, Acute pancreatitis, Surgery, Risk factor, business, Randomized Controlled Trials as Topic
Abstract

Recent studies have added to the controversy regarding the role of endoscopic retrograde cholangiopancreatography (ERCP) in the management of patients with acute biliary pancreatitis. This debate is due in part to a marked difference between the trials regarding the definition of “complication” as an outcome. This study sought to determine the effect of early ERCP versus conservative treatment on local pancreatic complications (defined by the current classification) experienced by patients with acute biliary pancreatitis. Electronic databases (Cochrane Central Register of Controlled Trials, MEDLINE, Science Citation Index) and conference proceedings were searched for relevant randomized controlled trials up to December 2007. The effect of both treatment strategies on local pancreatic complications was calculated with random-effects models. Five trials involving 717 patients were included in this systematic review. Pooled analysis of all the patients with acute pancreatitis did not demonstrate a statistically significant difference between the two treatment strategies (relative risk [RR], 0.94; 95% confidence interval [CI], 0.63–1.40; p = 0.62). Similar results were observed after subgroup analysis based on the severity of disease as follows: mild acute pancreatitis (RR, 0.79; 95% CI, 0.26–2.47; p = 0.69); severe acute pancreatitis (RR, 0.77; 95% CI, 0.30–1.98; p = 0.59). The early use of ERCP did not result in a significantly reduced risk of local pancreatic complications for either patients with mild acute pancreatitis or those with severe form of the disease.

Published
2008
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2. Contents Vol. 7, 2007

Author

Maxim S. Petrov, Alexander S. Gordetzov, J. A. Murphy, György M. Buzás, Timothy A. Woodward, Werner Van Steenbergen, Ru F. Chen, H. Oettle, Valerio Di Carlo, Zhi H. Li, Osman Yüksel, Quan B. Zhou, H. Riess, Eduardo Moreno-Osset, Marco Del Chiaro, Lorenzo Fantini, Gwen Lomberk, John A. Dumot, Daniel H. Palmer, Maria A. Caligo, Michelle A. Anderson, Fen Y. Yu, Mark J. Truty, Massimo Falconi, Silvano Presciuttini, Gulsen Yilmaz, David N. Criddle, Roberto Salvia, Ömer Başar, Fernando Gómez, Antonio López, Giorgio Casari, Emre Yıldırım, Jia J. Zhou, Maria Schipper, R.K. Vasishta, Martin E. Fernandez-Zapico, Mansour A. Parsi, María Jesús Martínez, R. Sopena, Pankaj Jain, Robert Sutton, J.D. Wig, Daniel D. Billadeau, Surakit Pungpapong, Jie Wang, Raffaele Pezzilli, P. Neuhaus, Alvaro Pascual-Leone, Euan McLaughlin, Hein G. Gooszen, S.K. Arora, Ji S. Chen, Steven D. Freedman, James M. Scheiman, J. Krysa, Karel J. van Erpecum, Mehmet Ibis, L. Bertacca, Laura Seynaeve, Qi B. Tang, Alessandro Zerbi, Raul Urrutia, Franco Mosca, Madhusudhan R. Sanaka, Nora Sartori, Kyung W. Noh, Paolo Pederzoli, Ricardo A. Cruciani, A. Steger, Ole H. Petersen, S. Majumdar, Leticia de la Cueva, Mikhail V. Kukosh, Fatma Meric Yilmaz, Zeynel Abidin Öztürk, Felipe Fregni, Antonio Maria Morselli-Labate, Philip R. Fischer, D.K. Bakshi, Tomás Ripollés, L. Singh, Biancamaria Longoni, Marco Polese, Matthew J. DiMagno, Erik Buskens, Ugo Boggi, Joel H. Rubenstein, Annemarie C. de Vries, Sandeep Nijhawan, Massimo Raimondo, Seyfettin Köklü, Qiu H. Pan, Marc G. Besselink, Michael B. Wallace, Mohammad A. Al-Haddad, and Ben U. Ridwan

Subjects
Hepatology, Traditional medicine, business.industry, Endocrinology, Diabetes and Metabolism, Gastroenterology, Medicine, business
Published
2007
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3. Early Prediction of Severity in Acute Pancreatitis Using Infrared Spectroscopy of Serum

Author

Maxim S. Petrov, Alexander S. Gordetzov, and Mikhail V. Kukosh

Subjects
medicine.medical_specialty, Hepatology, Minimal risk, business.industry, Endocrinology, Diabetes and Metabolism, Incidence (epidemiology), General surgery, Gastroenterology, Normal population, Inflammation, medicine.disease, Cystic fibrosis, medicine.anatomical_structure, Pancreatic cancer, Internal medicine, medicine, Pancreatitis, medicine.symptom, Pancreas, business
Abstract

Pancreatitis affects 0.5% people with cystic fibrosis (CF) in the UK and 0.01% of the normal population. Why do some with CF get pancreatitis and some not? And does pancreatitis in neonates result in pancreatic failure with no further inflammation or risk of pancreatic cancer? Review of the literature would suggest that 85% of those with CF have pancreatic destruction as children with minimal risk of further inflammatory or neoplastic changes. Those with a functioning pancreas are at risk of developing pancreatitis. There are several case series of pancreatic cancer reported in CF patients, but overall the risk is unknown. As patients with CF and pancreatic sufficiency are living longer, further studies to assess the risk of developing pancreatic cancer in this subgroup should be considered.

Published
2007
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4. Contents Vol. 23, 2006

Author

Gregor Vetter, C.D. Johnson, G. Srikanth, Koroush S. Haghighi, Dalibor Antolovic, Nikolay V. Emelyanov, Kazuhisa Yoshimoto, E.C.J. Consten, Marino Murazio, A. Kumar, L.S.F. Yo, Gennaro Clemente, R. Saxena, B. Pottakkat, Dirk J. Gouma, Dinesh Singhal, Katsuhiko Yanaga, Mikhail V. Kukosh, Hidejiro Kawahara, Abraham R. John, Ivo Giovannini, Shin Kon Kim, P.A. Yannopoulos, M. Gagner, Carlo Chiarla, Katsuya Hirai, Neerav Goyal, C. Fox, Dirk T. Ubbink, Yu Meng Tan, Maxim S. Petrov, Willem A. Bemelman, Kentaro Chochi, M. Emad Esmat, Christos Dervenis, Phillippe Taniere, Thomas M. van Gulik, G.R. Sagor, I.E. Katsoulis, J.I. Livingstone, Young Kyu Park, Bernard Launois, Young Jin Kim, Jörg Köninger, P. Basnyat, Arash Choudhry, G. Kouraklis, George Tzovaras, Jürgen Weitz, Arianeb Mehrabi, A. Arif, Gennaro Nuzzo, S. Singh, Jan Wind, S.S. Sikora, Khoon Hean Tay, Dong Yi Kim, Beat P. Müller-Stich, Salleh Ibrahim, H.M.E. Quarles van Ufford, Takashi Ichikura, Carsten N. Gutt, Jae Kyoon Joo, Felice Giuliante, V.K. Kapoor, Simon R. Bramhall, Hidekazu Sugasawa, Hideyuki Kashiwagi, Hidetaka Mochizuki, Ngian Chye Tan, A. Chaudhary, Seong Yeob Ryu, Markus W. Büchler, Steve M. M. de Castro, Susumu Kobayashi, H.G. Gooszen, J.F. Robotis, S. W. Polle, and Daan W. Hommes

Subjects
Traditional medicine, business.industry, Gastroenterology, Medicine, Surgery, business
Published
2006
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5. Early prediction of severity in acute pancreatitis using infrared spectroscopy of serum

Author

Maxim S, Petrov, Alexander S, Gordetzov, and Mikhail V, Kukosh

Subjects
Adult, Male, Spectrophotometry, Infrared, Middle Aged, Prognosis, Sensitivity and Specificity, Severity of Illness Index, Blood, C-Reactive Protein, Pancreatitis, Predictive Value of Tests, Acute Disease, Humans, Female, Prospective Studies, APACHE, Aged
Abstract

One of the main problems in the management of acute pancreatitis (AP) is the scarcity of accurate predictors of disease severity.In a prospective design, we compared APACHE II score, C-reactive protein (CRP) level, and infrared (IR) spectral absorption of serum (wavelength 940 nm) in 167 consecutive patients with AP, 34 with predicted severe and 133 with mild form.The IR spectral absorption levels on admission and at 24 h after admission were significantly (p0.05) lower in patients with severe AP. On admission, the sensitivity was 74, 56, and 44%; the specificity was 82, 83, and 81%; the positive predictive value was 51, 45, and 37%, and the negative predictive value was 92, 88, and 85%, for IR spectroscopy, APACHE II, and CRP, respectively. At 24 h, the sensitivity, specificity, positive predictive value, and negative predictive value was 82, 74, 44, and 94%; 65, 72, 37, and 89%; 68, 73, 39, and 90%, for IR spectroscopy, CRP, and APACHE II, respectively.IR spectroscopy seems to be useful for early detection of severe AP and, in turn, for identifying patients requiring treatment in the intensive care unit and who can benefit from novel therapies.

Published
2006

6. A randomized controlled trial of enteral versus parenteral feeding in patients with predicted severe acute pancreatitis shows a significant reduction in mortality and in infected pancreatic complications with total enteral nutrition

Author

Nikolay V. Emelyanov, Mikhail V. Kukosh, and Maxim S. Petrov

Subjects
Prophylactic antibiotic, Adult, Male, medicine.medical_specialty, Parenteral Nutrition, Necrosis, macromolecular substances, Infections, Enteral administration, Gastroenterology, law.invention, Enteral Nutrition, Randomized controlled trial, law, Internal medicine, medicine, Humans, Pancreatitis complications, In patient, APACHE, Aged, Analysis of Variance, business.industry, Middle Aged, medicine.disease, Prognosis, Abscess, Surgery, Parenteral nutrition, C-Reactive Protein, Treatment Outcome, Pancreatitis, Acute Disease, Acute pancreatitis, Female, medicine.symptom, business
Abstract

Background: Infectious complications are the main cause of late death in patients with acute pancreatitis. Routine prophylactic antibiotic use following a severe attack has been proposed but remains controversial. On the other hand, nutritional support has recently yielded promising clinical results. The aim of study was to compare enteral vs. parenteral feeding for prevention of infectious complications in patients with predicted severe acute pancreatitis. Methods: We screened 466 consecutive patients with acute pancreatitis. A total of 70 patients with objectively graded severe acute pancreatitis were randomly allocated to receive either total enteral nutrition (TEN) or total parenteral nutrition (TPN), within 72 h of onset of symptoms. Baseline characteristics were well matched in the two groups. Results: The incidence of pancreatic infectious complications (infected pancreatic necrosis, pancreatic abscess) was significantly lower in the enterally fed group (7 vs. 16, p = 0.02). In the TEN group, 7 patients developed multiple organ failure whereas 17 parenterally fed patients developed multiple organ failure (p = 0.02). Overall mortality was 20% with two deaths in the TEN group and twelve in the TPN group (p < 0.01). Conclusion: Early TEN could be used as prophylactic therapy for infected pancreatic necrosis since it significantly decreased the incidence of pancreatic infectious complications as well as the frequency of multiple organ failure and mortality.

Published
2006

7. Subject Index Vol. 7, 2007

Author

R.K. Vasishta, L. Bertacca, Daniel H. Palmer, Maria A. Caligo, Jie Wang, Alessandro Zerbi, Martin E. Fernandez-Zapico, Marco Del Chiaro, Hein G. Gooszen, David N. Criddle, Nora Sartori, Roberto Salvia, Fen Y. Yu, Gwen Lomberk, Giorgio Casari, Gulsen Yilmaz, Leticia de la Cueva, Philip R. Fischer, Valerio Di Carlo, Laura Seynaeve, James M. Scheiman, Osman Yüksel, Quan B. Zhou, H. Riess, John A. Dumot, Michelle A. Anderson, Daniel D. Billadeau, Timothy A. Woodward, H. Oettle, P. Neuhaus, Raffaele Pezzilli, Raul Urrutia, Kyung W. Noh, Ömer Başar, Silvano Presciuttini, Massimo Falconi, María Jesús Martínez, Fernando Gómez, Alexander S. Gordetzov, Franco Mosca, Marc G. Besselink, Jia J. Zhou, Marco Polese, Mehmet Ibis, Ji S. Chen, J. Krysa, Steven D. Freedman, Fatma Meric Yilmaz, Sandeep Nijhawan, Massimo Raimondo, R. Sopena, Euan McLaughlin, Qi B. Tang, Maxim S. Petrov, Ole H. Petersen, Matthew J. DiMagno, Eduardo Moreno-Osset, Lorenzo Fantini, D.K. Bakshi, A. Steger, Mikhail V. Kukosh, Paolo Pederzoli, J. A. Murphy, Zeynel Abidin Öztürk, Tomás Ripollés, L. Singh, S. Majumdar, Werner Van Steenbergen, Mark J. Truty, Felipe Fregni, Seyfettin Köklü, Ru F. Chen, Joel H. Rubenstein, Ricardo A. Cruciani, Surakit Pungpapong, Qiu H. Pan, Michael B. Wallace, Annemarie C. de Vries, Maria Schipper, Biancamaria Longoni, Mohammad A. Al-Haddad, György M. Buzás, Zhi H. Li, S.K. Arora, Ben U. Ridwan, Pankaj Jain, Robert Sutton, J.D. Wig, Alvaro Pascual-Leone, Karel J. van Erpecum, Erik Buskens, Ugo Boggi, Antonio López, Emre Yıldırım, Mansour A. Parsi, Madhusudhan R. Sanaka, and Antonio Maria Morselli-Labate

Subjects
Index (economics), Hepatology, business.industry, Endocrinology, Diabetes and Metabolism, Statistics, Gastroenterology, Medicine, Subject (documents), business
Published
2007
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8. Subject Index Vol. 23, 2006

Author

G. Kouraklis, Maxim S. Petrov, I.E. Katsoulis, Bernard Launois, Yu Meng Tan, Young Kyu Park, Ivo Giovannini, Jae Kyoon Joo, G. Srikanth, M. Emad Esmat, Carsten N. Gutt, Phillippe Taniere, Jürgen Weitz, L.S.F. Yo, Markus W. Büchler, Marino Murazio, A. Kumar, Khoon Hean Tay, P.A. Yannopoulos, Koroush S. Haghighi, Hidekazu Sugasawa, B. Pottakkat, Hidetaka Mochizuki, R. Saxena, Daan W. Hommes, Abraham R. John, Dinesh Singhal, Katsuhiko Yanaga, Neerav Goyal, Gregor Vetter, A. Arif, Thomas M. van Gulik, Gennaro Clemente, Arash Choudhry, M. Gagner, Felice Giuliante, Young Jin Kim, Kentaro Chochi, Carlo Chiarla, V.K. Kapoor, J.I. Livingstone, G.R. Sagor, Hidejiro Kawahara, A. Chaudhary, Seong Yeob Ryu, C. Fox, Nikolay V. Emelyanov, Simon R. Bramhall, Kazuhisa Yoshimoto, Steve M. M. de Castro, Jörg Köninger, S. W. Polle, Hideyuki Kashiwagi, Shin Kon Kim, H.M.E. Quarles van Ufford, Takashi Ichikura, Gennaro Nuzzo, P. Basnyat, George Tzovaras, Arianeb Mehrabi, Dirk J. Gouma, E.C.J. Consten, Ngian Chye Tan, Susumu Kobayashi, H.G. Gooszen, J.F. Robotis, Mikhail V. Kukosh, C.D. Johnson, Dalibor Antolovic, S.S. Sikora, Dong Yi Kim, S. Singh, Jan Wind, Dirk T. Ubbink, Willem A. Bemelman, Beat P. Müller-Stich, Salleh Ibrahim, Christos Dervenis, and Katsuya Hirai

Subjects
Index (economics), business.industry, Statistics, Gastroenterology, Medicine, Surgery, Subject (documents), business
Published
2006
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