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In order to graft β-cyclodextrin onto chitosan fibers as more as possible, amino group of chitosan fibers should be protected by benzaldehyde firstly. Based on the similar structure of chitosan and cellulose fibers, different experimental programs were employed to discuss the possibility of β-cyclodextrin grafted onto chitosan fibers in the similar method. By infrared spectral and UV–visible spectroscopy analysis, the results showed although benzaldehyde could be grafted to chitosan fibers successfully to protect amino group, β-cyclodextrin could not be grafted further.

A novel functional material was fabricated by combining levofloxacin microspheres with viscose nonwoven fabrics. The complex microspheres were made by w/o emulsion crosslinking technique. The morphologies of both microspheres and fabric composite were investigated by SEM. The drug release property was evaluated by UV. The antibacterial activity and cytotoxicity were tested by spread plate and cell culture method. The results showed that the microspheres had spherical shape and could be embedded into the viscose fabrics. The levofloxacin was released gradually within 168 hours and its release kinetics corresponded to diffusion-relaxation model. In addition, the antibacterial activity of the fabric was increased with prolonged drug releasing time and the complex fabrics had no obvious cytotoxicity. The functional material has great potential to be used as a wound dressing with antibacterial property.

The aim of the study was to investigate the grafting process of β-cyclodextrin onto chitosan fibers via epichlorohydrin as a crosslinking agent. The parameters influencing the efficiency of the grafting reaction were studied by L9 (34) orthogonal test. The amounts of β-cyclodextrin grafting onto the treated fibers were estimated in terms of levofloxacin content. The optimum process was found to be epichlorohydrin 0.64 ml, temperature25°C, post-reaction time 48h, pre-reaction time 4.5h when chitosan fibers were 0.48g. In the case, the inclusion amount of levofloxacin was 1.792mg/g, and the releasing amount was 0.845mg/g at 35°C. The modified and unmodified fibers were characterized by FTIR Spectroscopy , which indicated that β-CD grafted with chitosan fibers were prepared successfully.