71 results on '"Mi, Xiang"'
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2. Modified Linggui Zhugan Decoction protects against ventricular remodeling through ameliorating mitochondrial damage in post-myocardial infarction rats
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Mi Xiang, Xin Zhao, Yingdong Lu, Yang Zhang, Fan Ding, Lifei Lv, Yuling Wang, Zihuan Shen, Li Li, and Xiangning Cui
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Cardiology and Cardiovascular Medicine - Abstract
IntroductionModified Linggui Zhugan Decoction (MLZD) is a Traditional Chinese Medicine prescription developed from Linggui Zhugan Decoction (LZD) that has been used for the clinical treatment of ischemic cardiovascular diseases. However, the cardioprotective mechanism of MLZD against post-myocardial infarction (MI) ventricular remodeling remains unclear.MethodsWe explored the effects of MLZD on ventricular remodeling and their underlying mechanisms, respectively, in SD rats with MI models and in H9c2 cardiomyocytes with oxygen-glucose deprivation (OGD) models. The cardiac structure and function of rats were measured by echocardiography, HE staining, and Masson staining. Apoptosis, inflammation, mitochondrial structure and function, and sirtuin 3 (SIRT3) expression were additionally examined.ResultsMLZD treatment significantly ameliorated cardiac structure and function, and thus reversed ventricular remodeling, compared with the control. Further research showed that MLZD ameliorated mitochondrial structural disruption, protected against mitochondrial dynamics disorder, restored impaired mitochondrial function, inhibited inflammation, and thus inhibited apoptosis. Moreover, the decreased expression level of SIRT3 was enhanced after MLZD treatment. The protective effects of MLZD on SIRT3 and mitochondria, nevertheless, were blocked by 3-TYP, a selective inhibitor of SIRT3.DiscussionThese findings together revealed that MLZD could improve the ventricular remodeling of MI rats by ameliorating mitochondrial damage and its associated apoptosis, which might exert protective effects by targeting SIRT3.
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- 2023
3. Formal Social Support is Important to Quality of Life of Caregivers with Children with ASD: A Large-Scale Nationwide Survey
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Qingqing Ran, Liangzhi Tu, Yinghui Wu, Erliang Zhang, Huilun Li, Mi Xiang, and Ya Su
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- 2023
4. A DNA barcode library for woody plants in tropical and subtropical China
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Shi, Haoyou, Jin, Lu, Li, Ting, Zhao, Nan, Xu, Yong, Xiao, Tian-Wen, Ma, Chenxin, Li, Qiao-Ming, Lin, Luxiang, Shao, Xiao-Na, Li, Bu-Hang, Mi, Xiang-Cheng, Ren, Hai-Bao, Qiao, Xiu-Juan, Lian, Ju-Yu, Du, Hu, and Ge, Xue-Jun
- Abstract
A DNA barcode library for woody plants in tropical and subtropical China
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- 2023
- Full Text
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5. Beneficial effects of psyllium on the prevention and treatment of cardiometabolic diseases
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Chen Chen, Chang Shang, Laiyun Xin, Mi Xiang, Yuling Wang, Zihuan Shen, Linke Jiao, Fan Ding, and Xiangning Cui
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Dietary Fiber ,Cardiovascular Diseases ,Diabetes Mellitus ,Humans ,Obesity ,General Medicine ,Psyllium ,Food Science - Abstract
Cardiometabolic diseases are reaching epidemic proportions worldwide. Dietary fiber intake can improve the risk factors associated with CMD. Psyllium, especially its husk, is one of the most widely used dietary fiber supplements, which is often used to enrich cereals and other food products. Numerous pharmacological studies have investigated the active ingredients and therapeutic effects of psyllium and its extracts, including antioxidant, anti-tumor, antidiabetic, hypotensive, anti-inflammation, neuroprotection, antidiarrheal, and antiviral activities. In this review, we will summarize the available studies on the therapeutic potential and possible mechanisms of psyllium in treating CMDs, such as hyperlipidemia, diabetes mellitus, and its complications, hypertension, hyperuricemia and obesity, and its applications in food systems.
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- 2022
6. Regulatory mechanism of icariin in cardiovascular and neurological diseases
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Yuling Wang, Chang Shang, Yang Zhang, Laiyun Xin, Linke Jiao, Mi Xiang, Zihuan Shen, Chen Chen, Fan Ding, Yingdong Lu, and Xiangning Cui
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Pharmacology ,General Medicine - Abstract
Cardiovascular diseases (CVDs) and neurological diseases are widespread diseases with substantial rates of morbidity and mortality around the world. For the past few years, the preventive effects of Chinese herbal medicine on CVDs and neurological diseases have attracted a great deal of attention. Icariin (ICA), the main constituent of Epimedii Herba, is a flavonoid. It has been shown to provide neuroprotection, anti-tumor, anti-osteoporosis, and cardiovascular protection. The endothelial protection, anti-inflammatory, hypolipidemic, antioxidative stress, and anti-apoptosis properties of ICA can help stop the progression of CVDs and neurological diseases. Therefore, our review summarized the known mechanisms and related studies of ICA in the prevention and treatment of cardio-cerebrovascular diseases (CCVDs), to better understand its therapeutic potential.
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- 2022
7. Association of Changes of lifestyle behaviors before and during the COVID-19 pandemic with mental health: a longitudinal study in children and adolescents
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Mi Xiang, Yujie Liu, Shohei Yamamoto, Tetsuya Mizoue, and Keisuke Kuwahara
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China ,Nutrition and Dietetics ,Adolescent ,Depression ,COVID-19 ,Medicine (miscellaneous) ,Physical Therapy, Sports Therapy and Rehabilitation ,Anxiety ,Mental Health ,Humans ,Longitudinal Studies ,Child ,Life Style ,Pandemics - Abstract
Background We examined the prospective associations of changes in lifestyle behaviors before/during the COVID-19 pandemic, namely physical activity and screen time, with mental health. Furthermore, the impacts of physical activity and screen time on mental health during the pandemic were examined cross-sectionally. Methods A two-wave longitudinal study was conducted among 2423 children and adolescents in Shanghai, China. Lifestyle behavior variables (physical activity and screen time) and psychological variables (depressive symptoms, anxiety, and stress) were measured using a self-reported questionnaire in January and March 2020. A series of multivariable logistic regressions were performed to examine the associations between changes in lifestyle behaviors in two waves and psychological problems. The combined associations of physical activity and screen time with psychological problems were also explored using the second wave data. Results Compared to students with persistently short screen time before and during the COVID-19 pandemic, those with prolonged screen time (OR = 1·36 for depression, OR = 1·48 for anxiety) and those with persistently long screen time (OR = 1·70 for depression, OR = 2·13 for anxiety) reported a higher risk of psychological symptoms. The association between changes in physical activity and psychological symptoms was not statistically significant after adjustment for demographic factors, socioeconomic status, and screen time. During the COVID-19 pandemic, engaging in longer screen time (OR = 1·44 for depression, OR = 1·55 for anxiety) was associated with worsened psychological conditions, while engaging in increased physical activity (OR = 0·58 for depression, OR = 0·66 for anxiety) was associated with better psychological conditions. Conclusions Our study suggests that promoting physical activity and limiting leisure screen time during the COVID-19 pandemic are important to prevent and mitigate psychological problems in children and adolescents. Therefore, effective interventions targeting lifestyle behaviors are needed to protect children and adolescents’ physical and mental health.
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- 2022
8. 46‐2: Ultra‐Slim Direct‐Lit LCD Backlight Using Glass Light‐Guide Plate
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Allen Kirk Richard, Mi Xiang-Dong, Dmitri Vladislavovich Kuksenkov, Christopher M. Lynn, Songfeng Han, Byung Yun Joo, and Tokar Joshua Lee
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Liquid-crystal display ,Optics ,Materials science ,law ,business.industry ,Light guide ,Backlight ,business ,High dynamic range ,law.invention - Published
- 2021
9. 46‐1: Patterned Glass Diffuser (PGD) for MiniLED Backlights
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Hai-Wei Sun, Tzu-Ling Niu, David L Baker, Allen Kirk Richard, Guanglei Du, Ming Chen, Songfeng Han, Mi Xiang-Dong, Jen-Chieh Wu, Pamela Arlene Maurey, Josh Tokar, Michael X Ouyang, and Andrii Varanytsia
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Optics ,Materials science ,business.industry ,Backlight ,Diffuser (sewage) ,business ,High dynamic range - Published
- 2021
10. Qiliqiangxin Modulates the Gut Microbiota and NLRP3 Inflammasome to Protect Against Ventricular Remodeling in Heart Failure
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Yingdong, Lu, Mi, Xiang, Laiyun, Xin, Yang, Zhang, Yuling, Wang, Zihuan, Shen, Li, Li, and Xiangning, Cui
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Pharmacology ,Pharmacology (medical) - Abstract
Aims: Pathological left ventricular (LV) remodeling induced by multiple causes often triggers fatal cardiac dysfunction, heart failure (HF), and even cardiac death. This study is aimed to investigate whether qiliqiangxin (QL) could improve LV remodeling and protect against HF via modulating gut microbiota and inhibiting nod-like receptor pyrin domain 3 (NLRP3) inflammasome activation.Methods: Rats were respectively treated with QL (100 mg/kg/day) or valsartan (1.6 mg/kg/day) by oral gavage after transverse aortic constriction or sham surgery for 13 weeks. Cardiac functions and myocardial fibrosis were assessed. In addition, gut microbial composition was assessed by 16S rDNA sequencing. Furthermore, rats’ hearts were harvested for histopathological and molecular analyses including immunohistochemistry, immunofluorescence, terminal-deoxynucleotidyl transferase-mediated 2’-deoxyuridine 5’-triphosphated nick end labeling, and Western blot.Key findings: QL treatment preserved cardiac functions including LV ejection fractions and fractional shortening and markedly improved the LV remodeling. Moreover, HF was related to the gut microbial community reorganization like a reduction in Lactobacillus, while QL reversed it. Additionally, the protein expression levels like IL-1β, TNF-α, NF-κB, and NLRP3 were decreased in the QL treatment group compared to the model one.Conclusion: QL ameliorates ventricular remodeling to some extent in rats with HF by modulating the gut microbiota and NLRP3 inflammasome, which indicates the potential therapeutic effects of QL on those who suffer from HF.
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- 2022
11. Beneficial effects of cinnamon and its extracts in the management of cardiovascular diseases and diabetes
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Laiyun Xin, Zihuan Shen, Zhilin Jiang, Jialiang Gao, Chang Shang, Xuqin Fang, Yuling Wang, Mi Xiang, Hongchen Lin, Yingdong Lu, Yi Qu, and Xiangning Cui
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Cinnamomum zeylanicum ,Endothelium ,Anti-Inflammatory Agents ,Adipose tissue ,Blood lipids ,Inflammation ,Coronary Artery Disease ,Pharmacology ,Carbohydrate metabolism ,medicine.disease_cause ,Functional Food ,Diabetes mellitus ,medicine ,Humans ,Platelet activation ,Plant Extracts ,business.industry ,General Medicine ,medicine.disease ,medicine.anatomical_structure ,Diabetes Mellitus, Type 2 ,medicine.symptom ,business ,Oxidative stress ,Phytotherapy ,Food Science - Abstract
Cardiovascular diseases (CVDs) and diabetes are the leading causes of death worldwide, which underlines the urgent necessity to develop new pharmacotherapies. Cinnamon has been an eminent component of spice and traditional Chinese medicine for thousands of years. Numerous lines of findings have elucidated that cinnamon has beneficial effects against CVDs in various ways, including endothelium protection, regulation of immune response, lowering blood lipids, antioxidative properties, anti-inflammatory properties, suppression of vascular smooth muscle cell (VSMC) growth and mobilization, repression of platelet activity and thrombosis and inhibition of angiogenesis. Furthermore, emerging evidence has established that cinnamon improves diabetes, a crucial risk factor for CVDs, by enhancing insulin sensitivity and insulin secretion; regulating the enzyme activity involved in glucose; regulating glucose metabolism in the liver, adipose tissue and muscle; ameliorating oxidative stress and inflammation to protect islet cells; and improving diabetes complications. In this review, we summarized the mechanisms by which cinnamon regulates CVDs and diabetes in order to provide a theoretical basis for the further clinical application of cinnamon.
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- 2021
12. Mental health and its correlates among children and adolescents during COVID-19 school closure: The importance of parent-child discussion
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Teris Cheung, Suqin Tang, Mi Xiang, and Yu-Tao Xiang
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Male ,Parents ,China ,medicine.medical_specialty ,Adolescent ,Casual ,School closure ,media_common.quotation_subject ,education ,Anxiety ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,medicine ,Humans ,Parent-Child Relations ,Child ,Students ,Pandemics ,Depression (differential diagnoses) ,media_common ,Schools ,Depression ,SARS-CoV-2 ,Public health ,COVID-19 ,Life satisfaction ,Children and adolescent ,Mental health ,030227 psychiatry ,Psychiatry and Mental health ,Clinical Psychology ,Cross-Sectional Studies ,Mental Health ,Quarantine ,Female ,Parent-child discussion ,Psychological resilience ,medicine.symptom ,Psychology ,030217 neurology & neurosurgery ,Research Paper ,Clinical psychology ,Psychopathology - Abstract
Highlights • A representative sample of 4,342 primary and secondary school students were investigated. • The three most prevalent symptoms were: anxiety (24.9%), depression (19.7%), and stress (15.2%). • Students were generally satisfied with life and 21.4% became more satisfied with life. • Perceived benefit and parent-child discussion were protective factors of mental health. • Parent-child discussion was related to less symptoms even in students perceived no benefit from home quarantine., Background : School closures due to the COVID-19 outbreak have affected 87% of the world's students physically, socially, and psychologically, yet rigorous investigation into their mental health during this period is still lacking. Methods : A cross-sectional online survey of 4,342 primary and secondary school students from Shanghai, China was conducted during March 13–23, 2020. Besides demographic information, psychological distress (including depression, anxiety, and stress), life satisfaction, perceived impact of home quarantine, and parent-child discussions on COVID-19 were assessed. Results : The three most prevalent symptoms were: anxiety (24.9%), depression (19.7%), and stress (15.2%). Participants were generally satisfied with life and 21.4% became more satisfied with life during school closures. Senior grades were positively correlated with psychological symptoms and negatively associated with life satisfaction, whereas the perceived benefit from home quarantine and parent-child discussions on COVID-19 were negatively correlated with psychopathological symptoms and positively correlated with life satisfaction. Among participants who perceived no benefit from home quarantine, those who had discussions with their parents about COVID-19 experienced less depression, anxiety, and stress. Limitations Limitations included the inability to infer the casual relationship, no parental report for mental health of children aged 6 to 9, and the inadequate measurement of parent-child discussion. Conclusions : Mental health problems and resilience co-existed in children and adolescents during the COVID-19 outbreak. Given the important role of parent-child discussions, open communication between parents and children about the pandemic should be encouraged to help children and adolescents cope with mental health problems in public health crisis.
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- 2021
13. Nutrient supplementation among pregnant women in China: an observational study – ERRATUM
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Tao Han, Jingwen Dong, Jiangtao Zhang, Chenxiao Zhang, Yuxuan Wang, Zhiruo Zhang, and Mi Xiang
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Nutrition and Dietetics ,Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) - Published
- 2023
14. Poly- and perfluoroalkyl substances exposure during pregnancy and postpartum depression: Evidence from the Shanghai birth cohort
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Hui Wang, Tai Ren, Na Zhang, Weiping Xia, Mi Xiang, Jinjun Ran, and Jun Zhang
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Environmental Engineering ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,Environmental Chemistry ,General Medicine ,General Chemistry ,Pollution - Published
- 2023
15. Rotation of Polarization Angle in Gamma-Ray Burst Prompt Phase
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Hao-Bing Wang and Mi-Xiang Lan
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High Energy Astrophysical Phenomena (astro-ph.HE) ,Space and Planetary Science ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The rotations of the polarization angle (PA) with time (energy) can lead to the depolarization of the time-integrated (energy-integrated) polarization. However, we don't know how and when it will rotate. Here, we consider the magnetic reconnection model to investigate the polarizations, especially the PA rotations of GRB prompt emission. For the large-scale ordered aligned magnetic field configuration, we find that PAs will evolve with time (energy) for off-axis observations. Our studies show that the rotations of the PAs are due to the changes of the ``observed shape'' of the emitting region (before averaged). We apply our models to the single pulse burst of GRB 170101A and GRB 170114A with time-resolved PA observations. We find it can interpret the violent PA variation of GRB 170101A. The model could not predict the twice $90^{\circ}$ PA changes in GRB 170114A. Detailed model should be considered., Comment: 14 pages, 13 figures
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- 2023
16. Association between Sedentary Behavior during Leisure Time and Excessive Weight in Chinese Children, Adolescents, and Adults
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Ya Su, Xueyuan Li, Huilun Li, Jiawei Xu, and Mi Xiang
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Nutrition and Dietetics ,sedentary behavior ,leisure time ,excessive weight ,Chinese population ,Food Science - Abstract
(1) Background: Sedentary behavior is increasing in all age groups and is one of the most common lifestyles that is a risk factor for overweight and obesity; however, few studies have evaluated the impact of leisure-time sedentary behavior on overweight and obesity. This study aims to examine the distribution characteristics of different leisure-time sedentary behaviors and their effects on excessive weight in different age groups in the Chinese population to provide evidence for the development of behavioral interventions. (2) Methods: This study utilizes data from the 2004 to 2011 China Health and Nutrition Survey (CHNS). Participants ranged in age from 6 to 18 years or older and were from China. Weight and height were measured in the physical examination, and the sedentary behavior times during leisure periods were collected by using a questionnaire. Logistic regression models were performed for association analyses. (3) Results: A total of 36,169 participants were included in this study. The impact of screen-based sedentary leisure time on excessive weight is greater in middle-aged and older adults. For middle-aged adults, sedentary time periods spent on the Internet or video games were found to be significantly and positively associated with excessive weight (OR, 1.122, 95% CI, 1.005–1.253). In addition, for older adults, sedentary time periods spent watching television or videos were found to be significantly and positively associated with excessive weight (OR, 1.065, 95% CI, 1.035–1.095). (4) Conclusions: This study helps grasp the target population and provide evidence for the development of behavioral intervention guidelines.
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- 2023
17. Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke
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Zihuan Shen, Mi Xiang, Chen Chen, Fan Ding, Yuling Wang, Chang Shang, Laiyun Xin, Yang Zhang, and Xiangning Cui
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Pharmacology ,Stroke ,Neuroprotective Agents ,Glutamic Acid ,Humans ,General Medicine ,Receptors, N-Methyl-D-Aspartate ,Ischemic Stroke - Abstract
Glutamate-mediated excitotoxicity is an important mechanism leading to post ischemic stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most initially followed by ion transport protein dysfunction and disruption of ion homeostasis, which in turn leads to impaired glutamate release, reuptake, and excessive N-methyl-D-aspartate receptor (NMDAR) activation, promoting neuronal death. Despite extensive evidence from preclinical studies suggesting that excessive NMDAR stimulation during ischemic stroke is a central step in post-stroke damage, NMDAR blockers have failed to translate into clinical stroke treatment. Current treatment options for stroke are very limited, and there is therefore a great need to develop new targets for neuroprotective therapeutic agents in ischemic stroke to extend the therapeutic time window. In this review, we highlight recent findings on glutamate release, reuptake mechanisms, NMDAR and its downstream cellular signaling pathways in post-ischemic stroke damage, and review the pathological changes in each link to help develop viable new therapeutic targets. We then also summarize potential neuroprotective drugs and therapeutic approaches for these new targets in the treatment of ischemic stroke.
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- 2022
18. Blood lipid levels and all-cause mortality in older adults: the Chinese Longitudinal Healthy Longevity Survey 2008-2018
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Rongxi, Wang, Xiaoyue, Yu, Zhiqiang, Wang, Yujie, Liu, Hui, Chen, Shangbin, Liu, Chen, Xu, Yingjie, Chen, Xin, Ge, Danni, Xia, Ruijie, Chang, Gang, Xu, Mi, Xiang, Ying, Wang, Tian, Shen, Fan, Hu, and Yong, Cai
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Aged, 80 and over ,Male ,China ,Risk Factors ,Cholesterol, HDL ,Humans ,Female ,Cholesterol, LDL ,Longitudinal Studies ,Lipids ,Triglycerides ,Aged ,Retrospective Studies - Abstract
Proper blood lipid levels are essential for survival in older adults, but inconsistent relationships have been reported between blood lipids and all-cause mortality in the elderly.This retrospective longitudinal study analyzed data from 1,067 Chinese older adults enrolled in the Chinese Longitudinal Healthy Longevity Survey collected in 2008 and followed up until death or December 31, 2018. The outcome was all-cause mortality. Multivariate Cox regression analyses were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) with stratification by age (60-80, 80-100, or ≥100 years) for further analysis. The survival probability according to lipid profile quartiles was calculated using Kaplan-Meier curves and the log-rank test.The participants' mean age was 84.84 years, and 57.0% were female. In total, 578 individuals died, and 277 were lost to follow-up. The mean total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels were higher among those who died than among those who survived. Participants in the second HDL-C quartile and the highest LDL-C and triglyceride (TG) quartiles had 28% higher, 23% lower, and 49% lower risks of all-cause mortality, respectively. After further adjustment, the associations remained except for HDL-C, and additional associations were observed between all-cause mortality and the third TC and LDL-C quartiles and the second TG quartile (HR, 1.44; 95% CI, 1.01 to 2.06; HR, 0.68; 95% CI, 0.49 to 0.94; HR, 0.79; 95% CI, 0.62 to 0.99, respectively).Older adults should maintain an LDL-C level of 1.91-2.47 mmol/L and a TG level of no less than 1.66 mmol/L.
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- 2022
19. Saponins and their derivatives: Potential candidates to alleviate anthracycline-induced cardiotoxicity and multidrug resistance
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Pei-Rong, Qu, Zhi-Lin, Jiang, Ping-Ping, Song, Lan-Chun, Liu, Mi, Xiang, and Jie, Wang
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Pharmacology ,Antibiotics, Antineoplastic ,Humans ,Anthracyclines ,Saponins ,Cardiotoxicity ,Drug Resistance, Multiple - Abstract
Anthracyclines (ANTs) continue to play an irreplaceable role in oncology treatment. However, the clinical application of ANTs has been limited. In the first place, ANTs can cause dose-dependent cardiotoxicity such as arrhythmia, cardiomyopathy, and congestive heart failure. In the second place, the development of multidrug resistance (MDR) leads to their chemotherapeutic failure. Oncology cardiologists are urgently searching for agents that can both protect the heart and reverse MDR without compromising the antitumor effects of ANTs. Based on in vivo and in vitro data, we found that natural compounds, including saponins, may be active agents for other both natural and chemical compounds in the inhibition of anthracycline-induced cardiotoxicity (AIC) and the reversal of MDR. In this review, we summarize the work of previous researchers, describe the mechanisms of AIC and MDR, and focus on revealing the pharmacological effects and potential molecular targets of saponins and their derivatives in the inhibition of AIC and the reversal of MDR, aiming to encourage future research and clinical trials.
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- 2022
20. Blood lipids and all-cause mortality among old people: the Chinese Longitudinal Healthy Longevity Survey 2008-2018
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Rongxi Wang, Xiaoyue Yu, Zhiqiang Wang, Yujie Liu, Hui Chen, Shangbin Liu, Chen Xu, Yingjie Chen, Danni Xia, Xin Ge, Ruijie Chang, Gang Xu, Mi Xiang, Ying Wang, Tian Shen, Fan Hu, and Yong Cai
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General Medicine - Published
- 2022
21. Combined Effects of Vitamin D Supplementation and Endurance Exercise Training on Insulin Resistance in Newly Diagnosed type 2 Diabetes Mellitus Patients with Vitamin D Deficiency : Study Protocol for a Randomized Controlled Trial
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Xiaomin Sun, Junxiang Wei, Mi Xiang, and Zhen-Bo Cao
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Medicine (General) ,medicine.medical_specialty ,Medicine (miscellaneous) ,Newly diagnosed ,vitamin D deficiency ,law.invention ,Study Protocol ,R5-920 ,Insulin resistance ,Randomized controlled trial ,Endurance training ,law ,Internal medicine ,Type 2 diabetes mellitus ,medicine ,Humans ,Pharmacology (medical) ,Vitamin D ,Exercise ,Cholecalciferol ,Randomized Controlled Trials as Topic ,Hand Strength ,Vitamin d supplementation ,business.industry ,Type 2 Diabetes Mellitus ,Vitamin D Deficiency ,medicine.disease ,Endurance exercise ,Diabetes Mellitus, Type 2 ,Dietary Supplements ,Insulin Resistance ,business - Abstract
Background Although approximately 50% of Chinese with type 2 diabetes mellitus (T2DM) patients have vitamin D deficiency, studies regarding vitamin D supplementation on insulin resistance (IR) have mainly focused on non-Asians. Endurance exercise training (ET) enhances insulin-mediated glucose metabolism, which plays a critical role in T2DM prevention and control. However, the combined effects of vitamin D supplementation and ET on IR in T2DM patients are unclear. The objectives of this study is to investigate the synergistic effect of vitamin D supplementation combined with exercise training intervention on IR in T2DM patients. Methods and analysis We propose a 3-month randomized controlled trial among 60 T2DM patients aged 40–65, newly diagnosed with T2DM ≤ 1 year, and with stable HbA1c level (≤ 8.0%) in the past 3 months. The participants will be randomly allocated to the vitamin D group, vitamin D combined with exercise training group, exercise training group, and control group (CG) using a computer-generated random number sequence. At baseline, participants will undergo a medical review, anthropometric measurements, dual X-ray absorptiometry, a 75-g oral glucose tolerance test (OGTT), ankle-brachial index measurements, and physical fitness measurements and will complete related lifestyle questionnaires. Fasting blood lipid and glucose levels were also measured. In a 3-month intervention period, vitamin D intervention group will receive a dose of 1000 IU daily; exercise group will perform a 1-h endurance exercise 3 times per week (maximal heart rate, 60–80%), and the control group will receive apparently identical tablets. Additionally, all participants will be advised to maintain their normal diet and physical activities during the intervention. All measurements will be repeated at 3-month follow-up after the intervention with the primary outcome measure expressed as a change from baseline in insulin sensitivity and secretion. Secondary outcome measures will compare the changes in anthropometry, ankle-brachial index, and physical fitness factors (e.g., peak oxygen uptake, hand grip strength). Data will be managed and analyzed using the Statistical Package for the Social Sciences. Discussion This is the first study to conduct a randomized trial to clearly determine the independent and combined effects of vitamin D supplementation and endurance exercise trial on IR in Chinese T2DM patients as measured by OGTT. The findings from the proposed study will not only provide new evidences that vitamin D supplementation plays an important role in IR management but also develop a simple and efficient method to improve IR-associated metabolic diseases for T2DM patients. Trial registration Chinese Clinical Trial Registry ChiCTR1800015383, Registered on 28 March 2018
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- 2021
22. Protecting healthcare personnel from 2019-nCoV infection risks: lessons and suggestions
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Dahai Zhao, Z.Y. Zhang, Mi Xiang, Sai-Juan Chen, Chaolin Huang, Shelan Liu, and Shijian Li
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China ,medicine.medical_specialty ,Health Personnel ,Pneumonia, Viral ,Disease ,030230 surgery ,Occupational safety and health ,Betacoronavirus ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Occupational Exposure ,Environmental health ,Health care ,medicine ,Humans ,030212 general & internal medicine ,Pandemics ,SARS-CoV-2 ,business.industry ,Protective Devices ,Public health ,Risk of infection ,COVID-19 ,Outbreak ,International health ,General Medicine ,Infectious disease (medical specialty) ,Coronavirus Infections ,business - Abstract
The outbreak of a novel coronavirus disease (COVID-19, caused by the 2019-nCoV infection) in December 2019 is one of the most severe public health emergencies since the founding of People's Republic of China in 1949. Healthcare personnel (HCP) nationwide are facing heavy workloads and high risk of infection, especially those who care for patients in Hubei Province. Sadly, as of February 20, 2020, over two thousand COVID-19 cases are confirmed among HCP from 476 hospitals nationwide, with nearly 90% of them from Hubei Province. Based on literature search and interviews with some HCP working at Wuhan, capital city of Hubei, we have summarized some of the effective measures taken to reduce infection among HCP, and also made suggestions for improving occupational safety during an infectious disease outbreak. The experience and lessons learned should be a valuable asset for international health community to contain the ongoing COVID-19 epidemic around the world.
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- 2020
23. 63‐1: High Brightness Bendable Backlight Including a Glass Light Guide
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Allen Kirk Richard, Mi Xiang-Dong, Andrii Varanytsia, Cuno Alexander Lee, Mou Jin-Fa, and Tokar Joshua Lee
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Brightness ,Materials science ,Optics ,Liquid-crystal display ,business.industry ,law ,Light guide ,Backlight ,business ,law.invention - Published
- 2019
24. Nutrient supplementation among pregnant women in China: an observational study
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Mi Xiang, Tao Han, Jiangtao Zhang, Yuxuan Wang, Chenxiao Zhang, Jingwen Dong, and Z.Y. Zhang
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Vitamin ,China ,Medicine (miscellaneous) ,chemistry.chemical_compound ,Folic Acid ,Pregnancy ,Environmental health ,Vitamin D and neurology ,Nutrient supplementation ,Medicine ,Humans ,Vitamin D ,Child ,Vitamin A ,Nutrition and Dietetics ,Vitamin C ,business.industry ,Public Health, Environmental and Occupational Health ,medicine.disease ,Cross-Sectional Studies ,chemistry ,Dietary Supplements ,Vitamin B Complex ,Health education ,Observational study ,Female ,Pregnant Women ,business - Abstract
Objective:To clarify nutrient supplementation usage and primary source of information among pregnant women in China.Design:This cross-sectional study used information on nutrient supplementation and primary source of information collected via face-to-face interviews. Data on the usage of folic acid, Ca/vitamin D, Fe, vitamins, DHA and other dietary supplements were collected. Primary source of information was categorised as family/relatives, friends/co-workers, the Internet, books/magazines, television/radio, doctors, other people and oneself.Setting:Maternal and Child Health Hospital in Chengdu, China.Participants:One thousand eighty-one Chinese pregnant women aged ≥20 years with singleton pregnancies.Results:In all three trimesters of pregnancy, usage was highest and most stable for folic acid (81·7 %), followed by vitamins (vitamin A, B-group vitamins, vitamin C and multivitamins; 75·0 %), whereas Ca/vitamin D (51·4 %) and Fe (18·1 %) usage was low, potentially indicating a deficiency risk. All supplementation usage percentages increased with pregnancy duration (P < 0·05). Notably, approximately 10 % of the pregnant women in our study did not use any nutrient supplementation, and this was especially common in early pregnancy. More than 50 % of the women reported getting information on nutrient supplementation from family members, and about 30 % reported getting this information from doctors.Conclusions:Among pregnant women in China, awareness about nutrient supplementation increases as the pregnancy progresses, but some types of nutrient supplementation (such as Ca/vitamin D and Fe) remain at low levels. It is necessary to pay more attention to the health education of pregnant women in China, and the influence of family members should be emphasised.
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- 2021
25. Additional file 10 of Comparative transcriptomic analysis reveals an association of gibel carp fatty liver with ferroptosis pathway
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Zhang, Xiao-Juan, Zhou, Li, Lu, Wei-Jia, Du, Wen-Xuan, Mi, Xiang-Yuan, Li, Zhi, Li, Xi-Yin, Wang, Zhong-Wei, Wang, Yang, Duan, Ming, and Gui, Jian-Fang
- Abstract
Additional file 10: Checklist S1 Completed ARRIVE guidelines checklist. The checklist includes the ARRIVE Essential 10 and the Recommended Set.
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- 2021
- Full Text
- View/download PDF
26. Association Between Total Cholesterol and All-Cause Mortality in Oldest Old: A National Longitudinal Study
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Yong Cai, Rongxi Wang, Mi Xiang, Jiade Qin, Tian Shen, Fan Hu, Gang Xu, Xiaoyue Yu, Shangbin Liu, Ruijie Chang, Ying Wang, Zhiqiang Wang, Hui Chen, Yujie Liu, and Chen Xu
- Subjects
History ,Longitudinal study ,Polymers and Plastics ,Proportional hazards model ,business.industry ,Hazard ratio ,Blood lipids ,Context (language use) ,Lower risk ,Industrial and Manufacturing Engineering ,Confidence interval ,Medicine ,Business and International Management ,business ,Survival analysis ,Demography - Abstract
Background: In the context of accelerated global aging, blood lipid levels are directly related to the health status of oldest old. The common sense is that lower serum cholesterol levels are better, as higher cholesterol levels increase the risk of cardiovascular disease. However, a growing number of researches have questioned this especially for the oldest old. The current study was to assess the association between total cholesterol and all-cause mortality in a group of people aged 85 years old and over. Methods: In this retrospective longitudinal study, we selected 903 Chinese old participants who aged ≥85 years from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) at baseline in 2012. The participants were followed up until death or until December 31, 2014. The outcome of our study was all-cause mortality. The univariate and multivariate cox regression analyses were used to estimate Hazard ratios (HRs) and 95% confidence interval values of all-cause mortality. To analyze further the relationship between total cholesterol and all-cause mortality, we stratified the participants into three groups (
- Published
- 2021
27. Roles and mechanisms of puerarin on cardiovascular disease:A review
- Author
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Zhilin, Jiang, Xiangning, Cui, Peirong, Qu, Chang, Shang, Mi, Xiang, and Jie, Wang
- Subjects
Inflammation ,Pharmacology ,Puerarin ,Myocardial Ischemia ,RM1-950 ,General Medicine ,Cardiovascular disease ,Isoflavones ,Muscle, Smooth, Vascular ,Pueraria ,Drug Delivery Systems ,Traditional Chinese medicine ,Cardiovascular Diseases ,Heart Function Tests ,Endothelium, Vascular ,Therapeutics. Pharmacology ,Inflammation Mediators ,Platelet Aggregation Inhibitors ,Foam Cells ,Hypolipidemic Agents ,Pharmacological effect - Abstract
Cardiovascular diseases (CVDs) are now the leading cause of mortality and morbidity worldwide,resulting in a large global economic burden. Recently, complementary and alternative medicine, such as traditional Chinese medicine (TCM) have received great attention. Puerarin (Pue) is an isoflavone isolated from the roots of Pueraria lobata (Willd.) Ohwi (also named "Ge gen" in China), and is a versatile TCM herb used for the treatment of fever, diarrhea, diabetes mellitus CVDs and cerebrovascular diseases. Numerous lines ofin vitro studies, as well as in vivo animal experiments have established that Pue offers beneficial roles against the progression of atherosclerosis, ischemic heart diseases, heart failure hypertension and arrhythmia by inhibiting pathological processes, such as the mitigation of endothelium injury, protection against inflammation, the disturbance of lipid metabolism, protection against ischemic reperfusion injury, anti-myocardial remodeling and other effects. Here, we provide a systematic overview of the pharmacological actions and molecular targets of Pue in cardiovascular disease prevention and treatment, to provide insights into the therapeutic potential of Pue in treating cardiovascular diseases.
- Published
- 2022
28. The molecular mechanisms of ferroptosis and its role in cardiovascular disease
- Author
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Laiyun Xin, Yang Zhang, Yuling Wang, Xiangning Cui, Yan Wang, Mi Xiang, Yingdong Lu, and Chang Shang
- Subjects
Lipid Peroxides ,Programmed cell death ,Iron ,Lipid peroxidation ,Ischemia ,Cardiomyopathy ,RM1-950 ,Disease ,GPX4 ,chemistry.chemical_compound ,Metabolic Diseases ,medicine ,Animals ,Ferroptosis ,Humans ,Pharmacology ,Cell Death ,Metabolic disorder ,General Medicine ,medicine.disease ,chemistry ,Cardiovascular Diseases ,Cancer research ,Therapeutics. Pharmacology ,Oxidation-Reduction ,Intracellular - Abstract
Ferroptosis is a programmed iron-dependent cell death characterized by accumulation of lipid peroxides (LOOH) and redox disequilibrium. Ferroptosis shows unique characteristics in biology, chemistry, and gene levels, compared to other cell death forms. The metabolic disorder of intracellular LOOH catalyzed by iron causes the inactivity of GPX4, disrupts the redox balance, and triggers cell death. Metabolism of amino acid, iron, and lipid, including associated pathways, is considered as a specific hallmark of ferroptosis. Epidemiological studies and animal experiments have shown that ferroptosis plays an important character in the pathophysiology of cardiovascular disease such as atherosclerosis, myocardial infarction (MI), ischemia/reperfusion (I/R), heart failure (HF), cardiac hypertrophy, cardiomyopathy, and abdominal aortic aneurysm (AAA). This review systematically summarized the latest research progress on the mechanisms of ferroptosis. Then we report the contribution of ferroptosis in cardiovascular diseases. Finally, we discuss and analyze the therapeutic approaches targeting for ferroptosis associated with cardiovascular diseases.
- Published
- 2022
29. Impact of COVID-19 pandemic on children and adolescents' lifestyle behavior larger than expected
- Author
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Zhiruo Zhang, Mi Xiang, and Keisuke Kuwahara
- Subjects
Male ,2019-20 coronavirus outbreak ,China ,Coronavirus disease 2019 (COVID-19) ,Adolescent ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Pneumonia, Viral ,Article ,Screen Time ,Screen time ,Betacoronavirus ,SB, sedentary behavior ,Surveys and Questionnaires ,Pandemic ,Medicine ,Humans ,Longitudinal Studies ,Child ,Exercise ,Life Style ,Pandemics ,GPAQ, Global Physical Activity Questionnaire ,COVID-19, coronavirus disease 2019 ,biology ,business.industry ,SARS-CoV-2 ,COVID-19 ,biology.organism_classification ,Virology ,PA, physical activity ,Adolescent Behavior ,Female ,Cardiology and Cardiovascular Medicine ,business ,Coronavirus Infections ,Lifestyle behavior - Published
- 2020
30. 14-1: Patterned Holey Glass LGP Based Ultra-Thin 2D Local Dimming Backlight
- Author
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Andrew J Sullivan, Kirk R Allen, Dmitri Vladislavovich Kuksenkov, Tokar Joshua Lee, Steven S. Rosenblum, and Mi Xiang-Dong
- Subjects
010302 applied physics ,Materials science ,business.industry ,0103 physical sciences ,Optoelectronics ,02 engineering and technology ,Backlight ,021001 nanoscience & nanotechnology ,0210 nano-technology ,business ,01 natural sciences ,High dynamic range - Published
- 2018
31. Effects of Chios mastic gum and exercise on physical characteristics, blood lipid markers, insulin resistance, and hepatic function in healthy Japanese men
- Author
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Tomoko Fukazawa, Mio Nishimaki, Masayuki Konishi, Masaki Takahashi, Ilias Smyrnioudis, Shizuo Sakamoto, Mi Xiang, and Hyeon Ki Kim
- Subjects
0301 basic medicine ,medicine.medical_specialty ,medicine.medical_treatment ,Blood lipids ,Placebo ,Applied Microbiology and Biotechnology ,Article ,Hepatic function ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Insulin resistance ,Internal medicine ,medicine ,biology ,Triglyceride ,business.industry ,Insulin ,medicine.disease ,biology.organism_classification ,030104 developmental biology ,Endocrinology ,chemistry ,030220 oncology & carcinogenesis ,Pistacia lentiscus ,Homeostatic model assessment ,business ,Food Science ,Biotechnology - Abstract
The effects of Chios mastic gum (Pistacia lentiscus var. Chia) and exercise on physical characteristics, blood lipid markers, insulin resistance, and hepatic function were investigated in healthy, non-smoking Japanese men aged ≥ 40 years. Participants were allocated to control (C, 5 g/day placebo powder, n = 7), mastic (M, 5 g/day mastic powder, n = 7), or mastic plus physical activity groups (M + PA, 5 g/day mastic powder and 30-min exercise three times/week, n = 7), and measurements were taken at baseline, 3 and 6 months. Serum triglycerides were significantly reduced at 3 months in M and M + PA compared with C (P
- Published
- 2018
32. Association between anthropometric indices of obesity and risk of cardiovascular disease in Japanese men
- Author
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Mi, Xiang, Huanhuan, Hu, Teppei, Imai, Akiko, Nishihara, Naoko, Sasaki, Takayuki, Ogasawara, Ai, Hori, Tohru, Nakagawa, Shuichiro, Yamamoto, Toru, Honda, Hiroko, Okazaki, Akihiko, Uehara, Makoto, Yamamoto, Toshiaki, Miyamoto, Takeshi, Kochi, Masafumi, Eguchi, Taizo, Murakami, Makiko, Shimizu, Kentaro, Tomita, Satsue, Nagahama, Akiko, Nanri, Maki, Konishi, Shamima, Akter, Keisuke, Kuwahara, Ikuko, Kashino, Miwa, Yamaguchi, Isamu, Kabe, Tetsuya, Mizoue, Naoki, Kunugita, Seitaro, Dohi, and Y, Kobayashi
- Subjects
Adult ,Male ,medicine.medical_specialty ,Waist ,body mass index ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Risk Factors ,cardiovascular disease ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Obesity ,waist‐to‐height ratio ,Waist-to-height ratio ,Waist-Height Ratio ,business.industry ,Public Health, Environmental and Occupational Health ,Odds ratio ,Original Articles ,Anthropometry ,Middle Aged ,medicine.disease ,waist circumference ,030210 environmental & occupational health ,Confidence interval ,Cardiovascular Diseases ,Case-Control Studies ,Original Article ,business ,Body mass index ,Dyslipidemia - Abstract
Objectives We aimed to compare the association of body mass index (BMI), waist circumference (WC), and waist‐to‐height ratio (WHtR) with risk of cardiovascular disease (CVD) among middle‐aged working Japanese men. Methods A nested case‐control study was performed among middle‐aged male employees who underwent periodic health checkup. A total of 241 CVD cases were identified and matched individually on age, gender, and worksite with 1205 controls. Data on BMI, WC, WHtR, smoking, hypertension, diabetes, and dyslipidemia collected at 4 years before the event/index date were retrieved. Associations between BMI, WC, WHtR, and CVD risk were assessed by using conditional logistic regression models. Results The strength of the association of BMI, WC, and WHtR with CVD risk was similar. The smoking‐adjusted odds ratio (95% confidence interval) for CVD was 1.60 (1.38‐1.85), 1.53 (1.33‐1.78), and 1.56 (1.35‐1.81) for a 1 SD unit increase in BMI, WC, and WHtR respectively. After further adjustment for hypertension, diabetes, and dyslipidemia, these associations were attenuated but remained statistically significant. Conclusions Measures of general (BMI) and abdominal (WC and WHtR) obesity were similarly associated with CVD in middle‐aged Japanese men.
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- 2019
33. Sedentary behavior relates to mental distress of pregnant women differently across trimesters: An observational study in China
- Author
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Huigang Liang, Mi Xiang, and Z.Y. Zhang
- Subjects
Adult ,China ,Pregnancy Trimester, Third ,Psychological intervention ,03 medical and health sciences ,Mental distress ,Young Adult ,0302 clinical medicine ,Asian People ,Pregnancy ,Surveys and Questionnaires ,medicine ,Humans ,Exercise ,business.industry ,Confounding ,medicine.disease ,Mental health ,030227 psychiatry ,Psychiatry and Mental health ,Clinical Psychology ,Distress ,Pregnancy Trimester, Second ,Anxiety ,Observational study ,Female ,Pregnancy Trimesters ,Pregnant Women ,medicine.symptom ,Sedentary Behavior ,business ,030217 neurology & neurosurgery ,Stress, Psychological ,Clinical psychology - Abstract
The independent effect of sedentary behavior (SB) on maternal mental health is still unclear. The purpose of this study was to examine the different relationships of SB with maternal distress in pregnant women across the three trimesters, controlling for the confounding factors including physical activity (PA), diet and gestational weight gain.Survey data were collected from 1272 participants in different trimesters of pregnancy. The data were divided into three data sets based on trimester, and regression analysis was conducted on each data set. Both the linear and quadratic relationships between SB and mental distress were estimated.There was no significant association between SB and any mental distress symptoms in the first trimester. In the second trimester, SB was positively associated with higher mental overall distress symptoms (β=0.34, P0.001), including depress and anxiety. There is an inverted-U shaped curvilinear relationship between SB and mental distress in the third trimester, as SB-squared is significantly associated with mental overall distress (GSI: β=-0.65, P = 0.002, depression: β=-0.53, P = 0.014, anxiety: β=-0.46, P = 0.031).The data were collected from only one city in China, which may limit the generalizability of the findings for all Chinese women. This was an observational study and causality cannot be established.This study found that the relationship between SB and maternal mental distress depends on trimesters. The stage of pregnancy should be considered when designing interventions for pregnant women to change SB to reduce mental distress.
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- 2019
34. Using Gamification and Social Incentives to Increase Physical Activity and Related Social Cognition among Undergraduate Students in Shanghai, China
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Mi Xiang, Shunxing Zhang, Mengyun Luo, Huigang Liang, Dandan Mo, Yue Fang, Yuanyuan Dong, and Z.Y. Zhang
- Subjects
Gerontology ,Male ,China ,Adolescent ,Health, Toxicology and Mutagenesis ,Control (management) ,Psychological intervention ,lcsh:Medicine ,physical activity ,Intention ,Motor Activity ,Article ,law.invention ,Social Networking ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Cognition ,Randomized controlled trial ,WeChat ,law ,Social cognition ,Intervention (counseling) ,Humans ,gamification ,030212 general & internal medicine ,Social Behavior ,Students ,Exercise ,Internet ,Motivation ,social incentives ,lcsh:R ,Public Health, Environmental and Occupational Health ,Theory of planned behavior ,030229 sport sciences ,undergraduate students ,Incentive ,Female ,Self Report ,Psychology ,Social cognitive theory ,social networking service - Abstract
Gamification and social incentives are promising strategies to increase the effectiveness of web-based physical activity (PA) interventions by improving engagement. In this study, we designed a PA intervention integrating gamification and social incentives based on the most popular social networking service in China, WeChat. A controlled trial involving 52 Chinese undergraduate students was implemented to evaluate the effectiveness of the intervention. Subjects in the intervention group received a 7-week intervention. PA behavior and related social cognitive variables according to the theory of planned behavior were measured at the baseline and after the intervention. Daily physical activity duration was measured during the intervention. The results showed that PA-related subjective norms, perceived behavior control, and intention, as well as self-reported vigorous physical activity and moderate physical activity in the intervention group, were increased after the intervention, compared with the control group (p <, 0.05). During the intervention, perceived daily physical activity duration in the intervention group was on the rise, while it declined in the control group (p <, 0.001). The findings indicate that WeChat-based intervention integrating gamification and social incentives could effectively increase subjectively measured PA and related social cognition among Chinese undergraduate students and that it is a promising way to ameliorate the problem of insufficient PA among youths.
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- 2019
35. Polarization Predictions in the GRB Prompt Phase with the Internal Shock Model
- Author
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Mi-Xiang Lan, Siming Liu, Xue-Feng Wu, Hao-Bing Wang, and Siyao Xu
- Subjects
High Energy Astrophysical Phenomena (astro-ph.HE) ,Physics ,Photosphere ,010504 meteorology & atmospheric sciences ,Astrophysics::High Energy Astrophysical Phenomena ,Phase (waves) ,FOS: Physical sciences ,Astronomy and Astrophysics ,Radius ,Polarization (waves) ,Light curve ,01 natural sciences ,Computational physics ,Magnetic field ,Space and Planetary Science ,0103 physical sciences ,Dissipative system ,Astrophysics - High Energy Astrophysical Phenomena ,Gamma-ray burst ,010303 astronomy & astrophysics ,0105 earth and related environmental sciences - Abstract
As the standard gamma-ray burst (GRB) prompt-emission model, the internal shock (IS) model can reproduce the fast-rise and slow-decay features of the pulses in the GRB light curve. The time- and energy-dependent polarization can deliver important physical information on the emission region and can be used to test models. Polarization predictions for the GRB prompt phase with the magnetized IS model should be investigated carefully. The magnetic field of the magnetized IS model is very likely to be mixed and decays with radius. The synchrotron emission in the presence of such a decaying magnetic field can recover the Band-like spectrum of the GRB prompt phase. We investigate the dependence of the polarization of GRB prompt emission on both time and energy in the framework of the magnetized IS model. Due to the large range of parameters, it is hard to distinguish the magnetized IS model and the magnetic-reconnection model through polarization degree (PD) curves. The energy-dependent PD could increase toward the high-energy band for the magnetized IS model, while it decreases to zero above the megaelectronvolt band for the dissipative photosphere model. Therefore, we conclude that the energy dependence of PD can be used to distinguish these two models for the GRB prompt emission. Finally, we find that, independent of the observational energy band, the profiles of the $\xi_B-PD$ curve for the time-integrated and time-resolved PDs are very similar, where $\xi_B$ is the magnetic field strength ratio of the ordered component to the random component., Comment: 7 pages, 3 figures, accepted by ApJ
- Published
- 2021
36. 镁同位素地球化学研究新进展及其在碳酸岩研究中的应用
- Author
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Jie Chen, Yingli Gong, Lu Chen, Mi Xiang, and Shihong Tian
- Subjects
General Earth and Planetary Sciences ,Building and Construction ,Computer Science Applications - Published
- 2021
37. The prevalence and risk factors of PTSD symptoms among medical assistance workers during the COVID-19 pandemic
- Author
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Z.Y. Zhang, Shijian Li, Mi Xiang, Xueyuan Li, Yue Fang, Kun Qian, Jiahui Li, Jiawei Xu, and Bing Wang
- Subjects
Adult ,Male ,China ,medicine.medical_specialty ,Health Personnel ,Anxiety ,Logistic regression ,Article ,Stress Disorders, Post-Traumatic ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Surveys and Questionnaires ,Intervention (counseling) ,Pandemic ,Prevalence ,medicine ,Healthcare personnel ,Humans ,030212 general & internal medicine ,Psychiatry ,Pandemics ,Depression (differential diagnoses) ,Response rate (survey) ,business.industry ,Incidence (epidemiology) ,PTSD symptoms ,COVID-19 ,Middle Aged ,Mental health ,Psychiatry and Mental health ,Clinical Psychology ,Mental Health ,Female ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Background The outbreak of COVID 19 in December 2019 spread quickly and overwhelmed the local healthcare system of the epicenter. A total of 346 medical assistance teams with 42,600 reserve medics were mobilized from around the country for emergency assistance. This study aims to examine the incidence of mental health symptoms and predictors of Post-Traumatic Stress Disorders (PTSD) symptoms among the reserve medics working in Wuhan, the capital city of Hubei Province. Methods An anonymous survey was conducted from April 4–6, 2020 among the medics upon their returning home. A total of 225 surveys were returned with a response rate of 83%. The survey consisted of questionnaires about the medics' demographic information, social relations, mental health status (e.g. IES-R and DASS-21) and other work-related information. Mann-Whitney U Test, Kruskal-Wallis Test and hierarchical logistic regression models were used to examine the predictors of PTSD symptoms. Results During the stay in Wuhan, the medics experienced high levels of depression (46.7%), anxiety (35.6%) and stress symptoms (16.0%). Upon returning home, the overall prevalence of clinically concerned PTSD symptoms was as high as 31.6%. Further analyses revealed that PTSD symptoms and its subscales were significantly associated with age, collegial relationship and mental health status during their service. Conclusion The reserve medics reported a high prevalence of depression, anxiety and stress as well as clinically concerned PTSD symptoms. Comprehensive screening and intervention programs should be in place to help reserve medics cope with mental health challenges and build resilience during the COVID 19 pandemic., Highlights • The prevalence of PTSD symptoms among medical assistance members was higher than those in the general population. • Excellent collegial relationship was a protective factor of PTSD symptoms. • Mental health counseling was positively correlated with PTSD symptoms. • Depression symptom, anxiety symptoms and stress symptoms were risk factors of PTSD symptoms. • Preemptive measures could be taken to avoid or alleviate mental distress among medics in the future.
- Published
- 2020
38. Diurnal variation in the diving bradycardia response in young men
- Author
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Hyeon Ki Kim, Mio Nishimaki, Hiroshi Kawano, Karina Ando, Mi Xiang, Masayuki Konishi, Shizuo Sakamoto, and Hiroki Tabata
- Subjects
Adult ,Male ,Bradycardia ,Evening ,Apnea ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Heart Rate ,Heart rate ,medicine ,Humans ,Heart rate variability ,Mammalian diving reflex ,Morning ,Endocrine and Autonomic Systems ,business.industry ,Diurnal temperature variation ,Circadian Rhythm ,Diving Reflex ,Anesthesia ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
The present study aimed to examine diurnal variation of the diving bradycardia responses on the same day. Eighteen young men (age 26 ± 2 years; height 174.2 ± 6.0 cm; body mass 70.2 ± 8.1 kg; body fat 18.0 ± 3.8 %; mean ± standard deviation) participated in this study. Oral temperature, heart rate variability (HRV) from 5-min of electrocardiogram data, and diving bradycardia responses were measured at 0900, 1300, and 1700 hours daily. All participants performed diving reflex tests twice in the sitting position with the face immersed in cold water (1.9–3.1 °C) and apnea at midinspiration for a minimum of 30 s and as long as possible, in consecutive order. Oral temperature was found to be less in the morning (0900) than in the afternoon (1300) and evening (1700). In the frequency domain parameters of heart rate variability, the natural logarithms of high-frequency power were higher in the morning than in the evening. All participants showed bradycardia response to the two diving reflex tests. The peak values of R–R interval during the diving reflex test both for as long as possible and 30 s were longer in the morning than in the afternoon and evening. Our results indicated that the maximal bradycardia during the diving reflex test exhibits a diurnal variation, with peak levels at morning and gradual decrease towards the evening. The HRV indexes show the same variation.
- Published
- 2016
39. When and How Should Chinese Pregnant Women Exercise? A Longitudinal Study in China
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Masayuki Konishi, Hyeon Ki Kim, Yue Fang, Mi Xiang, Xueyuan Li, Shizuo Sakamoto, Hiroki Tabata, Jiawei Xu, Huanhuan Hu, Z.Y. Zhang, Hisao Shimizu, Mio Nishimaki, Takashi Arao, and Huigang Liang
- Subjects
Adult ,China ,Longitudinal study ,medicine.medical_specialty ,Pregnancy Trimester, Third ,Health, Toxicology and Mutagenesis ,Physical activity ,lcsh:Medicine ,physical activity ,030209 endocrinology & metabolism ,Infant birthweight ,Weight Gain ,Article ,Body Mass Index ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,Pregnancy ,medicine ,Birth Weight ,Humans ,Longitudinal Studies ,030212 general & internal medicine ,Exercise ,Obstetrics ,business.industry ,lcsh:R ,Infant, Newborn ,Public Health, Environmental and Occupational Health ,Chinese women ,medicine.disease ,Gestational Weight Gain ,Intensity (physics) ,infant birthweight ,Pregnancy Complications ,Quartile ,Gestation ,Female ,medicine.symptom ,Energy Intake ,business ,Weight gain - Abstract
This study aimed to examine when and how physical activity (PA) influences gestational weight gain (GWG) and infant birthweight (BW) by considering the PA&rsquo, s total volume, timing, intensity, and type, controlling for the influence of energy intake. A total of 1272 participants in different stages of pregnancy were recruited from hospital. The associations between PA and GWG or BW in the latter half of pregnancy were significant. Women with the highest PA volume in the third trimester had significantly lower risks of inadequate and excessive GWG by 69% (OR = 0.31, 95%CI: 0.10&ndash, 0.91) and 67% (OR = 0.33, 95% CI: 0.12&ndash, 0.91), respectively, compared to women in the lowest quartile. Women who achieved the recommended moderate intensity of PA during their second and third trimesters, independent of total volume of PA, had infants with significantly lower BWs compared to those who did not (&beta, = &minus, 0.15, SE = 66.33, p = 0.04, &beta, 0.20, SE = 64.54, p = 0.01, respectively). Therefore, the effects of total volume and intensity of PA on GWG and BW were different. Interventions to prevent inappropriate GWG and macrosomia may need to set different priorities and timing regarding total volume or intensity of PA.
- Published
- 2019
40. Polarization with a 3-dimensional Mixed Magnetic Field and Its Application to GRB 170817A
- Author
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Lan, Mi-Xiang, Geng, Jin-Jun, Wu, Xue-Feng, and Dai, Zi-Gao
- Subjects
High Energy Astrophysical Phenomena (astro-ph.HE) ,Astrophysics::High Energy Astrophysical Phenomena ,FOS: Physical sciences ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
A large-scale ordered magnetic field plays a very important role in the formation and acceleration of a gamma-ray burst (GRB) jet. During the GRB prompt phase, some dissipation processes may happen and disturb the magnetic field, making the field become random to some extent. Therefore, a mixed magnetic field consisting of an ordered component and a random component is plausible for the early afterglow phase. Here we investigate the polarization evolution and light curve of an afterglow under such a 3-dimensional mixed magnetic field. Three kinds of ordered component (i.e., aligned, toroidal and radial) are discussed. We find that the three cases are distinguishable through jet polarization evolution. The polarization angle for a 3D mixed magnetic field with an aligned ordered component can evolve gradually but only changes abruptly by $90^\circ$ in the toroidal and radial cases. Furthermore, during the reverse shock crossing time, the polarization degree (PD) can be non-zero for the toroidal case but roughly zero for the radial case. Since an aligned component in a jet corresponds to a magnetar central engine and a toroidal component corresponds to a black hole, GRB central engines are distinguishable through polarization observations even if the magnetic field is mixed in a jet. In addition, our polarization calculation can be applied to GRB 170817A associated with GW170817. Using the recently-observed PD upper limit $12\%$ of GRB 170817A at $t=244$ days, the magnetic field strength ratio of the ordered to random components in this afterglow is constrained to be $\lesssim0.9$., Comment: 26 pages, 7 figures, accepted by ApJ
- Published
- 2018
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41. Mild Decrease in Skin Temperature Reduces the Heart Rate during Moderate Exercise
- Author
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Hiroki Tabata, Mi Xiang, Karina Ando, Shizuo Sakamoto, Hyeon-Ki Kim, Masayuki Konishi, and Mio Nishimaki
- Subjects
03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,Internal medicine ,Heart rate ,medicine ,Cardiology ,Moderate exercise ,Skin temperature ,030209 endocrinology & metabolism ,030229 sport sciences ,business - Published
- 2017
42. Valence tautomerism and photodynamics observed in a dinuclear cobalt-tetraoxolene compound
- Author
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Fan Yu, Xin-yi Cai, Bao Li, Yu-min Zhang, Hao He, Ai-hua Li, Mi Xiang, Qi-gan Wu, and Shi-qi Cheng
- Subjects
Diffraction ,Valence (chemistry) ,Chemistry ,Stereochemistry ,chemistry.chemical_element ,Electron ,Electrochemistry ,Tautomer ,Inorganic Chemistry ,Crystallography ,Materials Chemistry ,Amine gas treating ,Irradiation ,Physical and Theoretical Chemistry ,Cobalt - Abstract
A di-nuclear compound, [(CoTPA)2(1,4-BQ)][AsF6]3 (1) (TPA = tris(2-pyridylmethyl)amine, 1,4-BQ = deprotonated 2,5-dihydroxy-1,4-benzoquinone), was formed by one electron oxidation of [(CoTPA)2(1,4-BQ)]2+ cations. The compound was characterized by X-ray diffraction, electrochemistry, ESR, thermal- and photo-induced magnetic measurements. Variable temperature magnetic measurements have demonstrated that valence tautomeric transition with a small hysteresis around room temperature and photo-excited phenomenon is exhibited. In addition, temperature-dependent hs–ls relaxation of the converted high-spin fraction after irradiation was also studied.
- Published
- 2015
43. Structural diversities and magnetic properties of azide-containing coordination polymers based on flexible tetra-pyridinate ligands
- Author
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Ai-hua Li, Yu-min Zhang, Fan Yu, Bao Li, and Mi Xiang
- Subjects
chemistry.chemical_classification ,biology ,Stereochemistry ,General Chemistry ,Polymer ,Condensed Matter Physics ,biology.organism_classification ,Helical chain ,Ion ,Crystallography ,chemistry.chemical_compound ,chemistry ,Antiferromagnetism ,Tetra ,General Materials Science ,Azide ,Spin canting - Abstract
By utilizing two similar flexible quadritopic ligands, tetrakis(4-pyridyloxymethyl)methane (4-TPOM) and tetrakis(3-pyridyloxymethyl)methane (3-TPOM), four new azido-containing coordination polymers with formulas [Mn3(4-TPOM)3(N3)6(H2O)6]n (1), [Ni(4-TPOM)(N3)2]n (2), [Mn(3-TPOM)2(N3)2(H2O)3(CH3OH)4]n (3) and [Co(3-TPOM)(N3)2]n (4) have been synthesized and structurally characterized. Compound 1 shows a 1D helical chain composed of six-coordinated MnII geometries and two-connected tetra-pyridinate ligands. Compound 2 exhibits a three-dimensional framework based on 1D Ni(II) chains with alternating double end-to-end (EE) and double end-on (EO) azide bridges and tetrapyridyl ligands in a highly distorted conformation. Compound 3 shows a 2D layer composed of six-coordinated MnII geometries with mono-dentate azide ions and two types of two-connected tetra-pyridinate ligands. Compound 4 exhibits a three-dimensional framework based on 1D Co(II) chains with double end-to-end (EE) azide bridges and tetrapyridyl ligands in a cross-shaped conformation. Magnetic investigations on complexes 2 and 4 revealed antiferromagnetic interactions through the bridged azide ligands. In addition, the magnetic measurement reveals that 2 exhibits weak antiferromagnets, which might be caused by spin canting.
- Published
- 2015
44. New test of weak equivalence principle using polarized light from astrophysical events
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He Gao, Peter Mészáros, Jun-Jie Wei, Xue-Feng Wu, Z. G. Dai, and Mi Xiang Lan
- Subjects
High Energy Astrophysical Phenomena (astro-ph.HE) ,High Energy Physics - Theory ,Physics ,Photon ,010308 nuclear & particles physics ,Crab Pulsar ,Astrophysics::High Energy Astrophysical Phenomena ,FOS: Physical sciences ,Astrophysics::Cosmology and Extragalactic Astrophysics ,General Relativity and Quantum Cosmology (gr-qc) ,Astrophysics ,Polarization (waves) ,01 natural sciences ,Shapiro delay ,General Relativity and Quantum Cosmology ,Galaxy ,High Energy Physics - Phenomenology ,Gravitational potential ,High Energy Physics - Phenomenology (hep-ph) ,High Energy Physics - Theory (hep-th) ,0103 physical sciences ,Test particle ,Astrophysics - High Energy Astrophysical Phenomena ,Gamma-ray burst ,010303 astronomy & astrophysics - Abstract
Einstein's weak equivalence principle (WEP) states that any freely falling, uncharged test particle follows the same identical trajectory independent of its internal structure and composition. Since the polarization of a photon is considered to be part of its internal structure, we propose that polarized photons from astrophysical transients, such as gamma-ray bursts (GRBs) and fast radio bursts (FRBs), can be used to constrain the accuracy of the WEP through the Shapiro time delay effect. Assuming that the arrival time delays of photons with different polarizations are mainly attributed to the gravitational potential of the Laniakea supercluster of galaxies, we show that a strict upper limit on the differences of the parametrized post-Newtonian parameter $\gamma$ value for the polarized optical emission of GRB 120308A is $\Delta\gamma, Comment: 7 pages, 1 table. Updated to match the published version
- Published
- 2017
45. Study on the Structures of Two Booster Pellets Having High Initiation Capacity
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Zhao Hai-Xia, Liu Hong-Rong, Hu Li-shuang, Cao Xiong, Hu Shuang-Qi, and Mi Xiang-Chao
- Subjects
Booster (rocketry) ,Physics and Astronomy (miscellaneous) ,Explosive material ,Nuclear engineering ,fungi ,Survivability ,Pellets ,Environmental science ,Explosive train - Abstract
Insensitive munitions (IM) improve the survivability of both weapons and their associated platforms, which can lead to a reduction in casualties, mission losses, and whole life costs. All weapon systems contain an explosive train that needs to meet IM criteria but reliably initiate a main charge explosive. To ensure that these diametrically opposed requirements can be achieved, new highly effective booster charge structures were designed. The initiation capacity of the two booster pellets was studied using varied composition and axial-steel-dent methods. The results showed that the two new booster pellets can initiate standard main charge pellets with less explosive mass than the ordinary cylindrical booster pellet. The numerical simulation results were in good agreement with the experiment results.
- Published
- 2014
46. Spherical Nanometer Strontium Carbonate by Ultrasonic Method in the Water Phase
- Author
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Zhan Shou Yang, Mi Xiang Qi, and Shu Ya Wang
- Subjects
inorganic chemicals ,musculoskeletal diseases ,Materials science ,Scanning electron microscope ,Strontium carbonate ,General Engineering ,Mineralogy ,chemistry.chemical_compound ,Chemical engineering ,chemistry ,Phase (matter) ,Nano ,Slurry ,Nanometre ,Orthorhombic crystal system ,Strontium oxide - Abstract
strontium carbonate nanopowder materials were synthesized using Sr(OH)2 and Na2CO3 or CO2 as starting materials in the water by ultrasonic irradiation at 3h,and adding suitable amount of EDTA morphology agent.samples were characterized by scanning electron microscope (SEM) and X-ray diffraction (XRD) through separating strontium oxide solution slurry through by centrifuge , washing strontium carbonate slurry by ethanol.XRD and SEM showed that These products were found to be orthorhombic and spherical nanometer strontium carbonate and to be explained the growth mechanism of nano strontium carbonate powder.
- Published
- 2014
47. Effects of Different Intensities of Endurance Exercise in Morning and Evening on the Lipid Metabolism Response
- Author
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Hyeon-Ki, Kim, Karina, Ando, Hiroki, Tabata, Masayuki, Konishi, Masaki, Takahashi, Mio, Nishimaki, Mi, Xiang, and Shizuo, Sakamoto
- Subjects
Research Article - Abstract
To study the effects of different exercise intensity performed at different exercise times on lipid metabolism response during prolonged exercise. Nine young men performed endurance exercise at different exercise intensities (60%VO2max or Fatmax) in the morning (9 am to 10 am) or evening (5 pm to 6 pm); blood samples were collected before exercise and immediately and one and two hours after exercise completion. Expired gas was analyzed from the start of exercise until two hours after exercise completion. There were no significant changes in catecholamine (adrenaline and noradrenaline) and free fatty acid levels between morning and evening trials for each endurance exercise intensity. However, the morning and evening trials both exhibited significantly higher lipid oxidation at Fatmax than that at 60%VO2max. These results suggest that exercise at Fatmax offers greater lipid oxidation than that at 60%VO2max, regardless of exercise timing.
- Published
- 2016
48. All-glass, lenticular lens light guide plate by mask and etch
- Author
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Kanungo Mandakini, Shenping Li, Pam Maurey, Wanda Janina Walczak, Haregewine Tadesse, Mark Alejandro Quesada, Carleton Tracie Lynne, Mi Xiang-Dong, Li Liu, Lou Stempin, Wageesha Senaratne, and Len Dabich
- Subjects
Brightness ,Liquid-crystal display ,Materials science ,business.industry ,Light guide ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,Led array ,Aspect ratio (image) ,Electronic, Optical and Magnetic Materials ,law.invention ,010309 optics ,Lenticular lens ,Optics ,law ,0103 physical sciences ,White light ,IRIS (biosensor) ,0210 nano-technology ,business - Abstract
All glass, lenticular lens array, light guide substrates were fabricated in a single mask and etch procedure enabling 1D local light-confinement from an edge-injected LED array. Lenticular structures of sufficient resolution (width & pitch: 100–200 µm) were etched along the length of the thin-slab glass surface, at depths in the range 40–90 µm using an etchant optimized for the alkali-borosilicate composition (Corning Iris Glass). These structures’ aspect ratio (W/H 80%) along the lenticular corridors. The all-glass and high-transmission nature of the iris glass composition enabled higher brightness operation and yielded negligible color-shift.
- Published
- 2019
49. Polarization with a Three-dimensional Mixed Magnetic Field and Its Application to GRB 170817A
- Author
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Jin-Jun Geng, Zi-Gao Dai, Xue-Feng Wu, and Mi-Xiang Lan
- Subjects
Physics ,Shock wave ,Condensed matter physics ,Space and Planetary Science ,Astronomy and Astrophysics ,Gamma-ray burst ,Polarization (waves) ,Magnetic field - Published
- 2019
50. Gradient analysis and environmental interpretation of understory herb-layer communities in Xiaoshegou of Lingkong Mountain, Shanxi, China
- Author
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Ouyang Shuai, Zhou Zhi-Yong, Yu Min, Kang Feng-Feng, Sun Jian-xin, and MI Xiang-Cheng
- Subjects
Forest floor ,Gradient analysis ,Biotic component ,Ecology ,Canonical correspondence analysis ,Community structure ,Environmental science ,Ordination ,Plant Science ,Vegetation ,Understory ,Ecology, Evolution, Behavior and Systematics - Abstract
Aims Many past practices in afforestation and forest management were instrumented for addressing the issues of tree species selection, planting regimes and development of overstory structure, but neglected understory vegetation. Our objective was to determine the controlling factors of herb-layer plant distribution and the importance of topography in determining local-scale spatial patterns of herbaceous plants. Methods The occurrence and distribution of herb-layer plants were investigated on 26 plots in the Xiaoshegou catchment of Lingkong Mountain, Shanxi Province, China. Community types were classified using two-way indicator species analysis (TWINSPAN) and the relationship between the distribution and abundance of herb-layer species and environmental gradients was analyzed using the canonical correspondence analysis (CCA) ordination method. Forward selection and Monte Carlo permutation test were used to select the factors important in determining the herb-layer plant distribution. Partial CCA (PCCA) was also performed to partition the variance that was explainable by categorical habitat and biotic factors studied. Important findings The 26 survey plots were classified into six groups characterized by the dominant overstory tree species. The results of CCA ordination reflected the relationship between herb-layer community structure and selective environmental variables. The classification of 26 plots in CCA ordination was consistent with the result of TWINSPAN. Forward selection and Monte Carlo test suggested that stand type, soil nutrients and slope position were the most important factors determining understory plant distribution. PCCA revealed that habitat and biotic factors together explained 42.9% of variance in the distribution of understory herbaceous plants. Habitat factors alone explained 31.8% of the variance, biotic factors alone explained 7.8% of the variance and interactionbetween habitat and biotic factors explained 3.2% of the variance. The partitioning of variance using the PCCA helped with identifying the important habitat factors regulating understory herbaceous plant distribution at the study site. However, the fact that more than half of the variance was unaccounted for by the factors studied suggests that other factors we did not measure could also play a role in determining the occurrence and distribution of herbaceous plants on the forest floor, e.g., human activities and random events. Our study demonstrates the importance of both topography and overstory tree species in determining the occurrence and distribution of herb-layer plant species in temperate forest of mountainous areas.
- Published
- 2013
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