20 results on '"Meng-Shiue Lee"'
Search Results
2. Nanoparticles-mediated CRISPR-Cas9 gene therapy in inherited retinal diseases: applications, challenges, and emerging opportunities
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Yueh, Chien, Yu-Jer, Hsiao, Shih-Jie, Chou, Ting-Yi, Lin, Aliaksandr A, Yarmishyn, Wei-Yi, Lai, Meng-Shiue, Lee, Yi-Ying, Lin, Tzu-Wei, Lin, De-Kuang, Hwang, Tai-Chi, Lin, Shih-Hwa, Chiou, Shih-Jen, Chen, and Yi-Ping, Yang
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Retinal Diseases ,Biomedical Engineering ,Humans ,Nanoparticles ,Pharmaceutical Science ,Molecular Medicine ,Medicine (miscellaneous) ,Bioengineering ,Prospective Studies ,Genetic Therapy ,CRISPR-Cas Systems ,Applied Microbiology and Biotechnology ,Retina - Abstract
Inherited Retinal Diseases (IRDs) are considered one of the leading causes of blindness worldwide. However, the majority of them still lack a safe and effective treatment due to their complexity and genetic heterogeneity. Recently, gene therapy is gaining importance as an efficient strategy to address IRDs which were previously considered incurable. The development of the clustered regularly-interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) system has strongly empowered the field of gene therapy. However, successful gene modifications rely on the efficient delivery of CRISPR-Cas9 components into the complex three-dimensional (3D) architecture of the human retinal tissue. Intriguing findings in the field of nanoparticles (NPs) meet all the criteria required for CRISPR-Cas9 delivery and have made a great contribution toward its therapeutic applications. In addition, exploiting induced pluripotent stem cell (iPSC) technology and in vitro 3D retinal organoids paved the way for prospective clinical trials of the CRISPR-Cas9 system in treating IRDs. This review highlights important advances in NP-based gene therapy, the CRISPR-Cas9 system, and iPSC-derived retinal organoids with a focus on IRDs. Collectively, these studies establish a multidisciplinary approach by integrating nanomedicine and stem cell technologies and demonstrate the utility of retina organoids in developing effective therapies for IRDs.
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- 2022
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3. Corrigendum to ‘Characterizing deep brain biosignals: The advances and applications of implantable MEMS-based devices’ [Materials Today Advances 16 (2022) 100322]
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Hsin-Yu Wu, Kao-Jung Chang, Ximiao Wen, Aliaksandr A. Yarmishyn, He-Jhen Dai, Kai-Hsiang Chan, Yu-Jer Hsiao, Ming-Teh Chen, Yueh Chien, Hsin-I Ma, Wensyang Hsu, Meng-Shiue Lee, and Shih-Hwa Chiou
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Mechanical Engineering ,General Materials Science - Published
- 2023
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4. Nature-Inspired Surface Structures Design for Antimicrobial Applications
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Meng-Shiue Lee, Hussein Reda Hussein, Sheng-Wen Chang, Chia-Yu Chang, Yi-Ying Lin, Yueh Chien, Yi-Ping Yang, Lik-Voon Kiew, Ching-Yun Chen, Shih-Hwa Chiou, and Chia-Ching Chang
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Inorganic Chemistry ,Organic Chemistry ,General Medicine ,Physical and Theoretical Chemistry ,Molecular Biology ,Spectroscopy ,Catalysis ,Computer Science Applications - Abstract
Surface contamination by microorganisms such as viruses and bacteria may simultaneously aggravate the biofouling of surfaces and infection of wounds and promote cross-species transmission and the rapid evolution of microbes in emerging diseases. In addition, natural surface structures with unique anti-biofouling properties may be used as guide templates for the development of functional antimicrobial surfaces. Further, these structure-related antimicrobial surfaces can be categorized into microbicidal and anti-biofouling surfaces. This review introduces the recent advances in the development of microbicidal and anti-biofouling surfaces inspired by natural structures and discusses the related antimicrobial mechanisms, surface topography design, material application, manufacturing techniques, and antimicrobial efficiencies.
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- 2023
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5. Characterizing deep brain biosignals: The advances and applications of implantable MEMS-based devices
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Hsin-Yu Wu, Kao-Jung Chang, Ximiao Wen, Aliaksandr A. Yarmishyn, He-Jhen Dai, Kai-Hsiang Chan, Hsiao Yu-Jer, Ming-Teh Chen, Yueh Chien, Hsin-I Ma, Wensyang Hsu, Meng-Shiue Lee, and Shih-Hwa Chiou
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Mechanical Engineering ,General Materials Science - Published
- 2022
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6. Flexible, multifunctional neural probe with liquid metal enabled, ultra-large tunable stiffness for deep-brain chemical sensing and agent delivery
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Harold G. Monbouquette, Meng-Shiue Lee, Yu Ting Chow, Shan Huang, Ximiao Wen, Bo Wang, Pei-Shan Chung, Pei-Yu Chiou, Nigel T. Maidment, I-Wen Huang, and Tingyi Leo Liu
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Liquid metal ,Materials science ,Polymers ,Bioinformatics ,Orders of magnitude (temperature) ,Biomedical Engineering ,Biophysics ,chemistry.chemical_element ,Gallium ,Bioengineering ,Nanotechnology ,Biosensing Techniques ,02 engineering and technology ,01 natural sciences ,Article ,Analytical Chemistry ,Microfluidic channel ,Electrochemistry ,medicine ,Animals ,Humans ,Electrodes ,Flexible electronics ,Electrochemical biosensors ,010401 analytical chemistry ,technology, industry, and agriculture ,Temperature ,Neurosciences ,Brain ,Stiffness ,General Medicine ,021001 nanoscience & nanotechnology ,Electrodes, Implanted ,Rats ,0104 chemical sciences ,Brain implant ,Neural probes ,chemistry ,Drug delivery ,Implanted ,medicine.symptom ,0210 nano-technology ,Biotechnology - Abstract
Flexible neural probes have been pursued previously to minimize the mechanical mismatch between soft neural tissues and implants and thereby improve long-term performance. However, difficulties with insertion of such probes deep into the brain severely restricts their utility. We describe a solution to this problem using gallium (Ga) in probe construction, taking advantage of the solid-to-liquid phase change of the metal at body temperature and probe shape deformation to provide temperature-dependent control of stiffness over 5 orders of magnitude. Probes in the stiff state were successfully inserted 2 cm-deep into agarose gel “brain phantoms” and into rat brains under cooled conditions where, upon Ga melting, they became ultra soft, flexible, and stretchable in all directions. The current 30 μm-thick probes incorporated multilayer, deformable microfluidic channels for chemical agent delivery, electrical interconnects through Ga wires, and high-performance electrochemical glutamate sensing. These PDMS-based microprobes of ultra-large tunable stiffness (ULTS) should serve as an attractive platform for multifunctional chronic neural implants.
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- 2019
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7. Single-type reporter multiplexing with A single droplet through bead-based digital microfluidics
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Meng-Shiue, Lee, Yen-Chia, Chang, Hong-Yuan, Huang, and Wensyang, Hsu
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Immunoassay ,Limit of Detection ,Tumor Necrosis Factor-alpha ,Microfluidics ,Clinical Biochemistry ,Drug Discovery ,Humans ,Pharmaceutical Science ,Spectroscopy ,Analytical Chemistry - Abstract
With the limited sample volume, the droplet-based microfluidic becomes attractive in biomedical diagnosis, especially for measuring multiple analytes. Usually, for multiplexing by parallel processing, a larger sample volume is required. In our previous study, simultaneously detecting two analytes from a single droplet was first achieved by measuring different fluorescence wavelengths for different analytes. However, the number of detectable analytes could be limited by the spectral resolution of fluorescence. Here a different approach is proposed for multiplexing by sharing a single droplet in multiple sub-assays. Therefore, only a single-type reporter, i.e., the fluorescence with the same wavelength, is needed for detection of different analytes from a single sample droplet, called single-type reporter multiplexing (STRM). The standard curves of two analytes, human IL-1β and human TNF-α, are demonstrated. The required sample volume for one measurement is only 520 nL; the total duration of the on-chip process is less than 50 min. The limits of detection (LOD) of human IL-1β and human TNF-α are about 1.14 and 0.97 pg/mL, respectively. It is shown that the proposed bead-based digital microfluidic immunoassay can achieve multiple analytes detection with low LOD from a single sample droplet using the single-type reporter, which has never been achieved before.
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- 2022
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8. Bead Number Effect in a Magnetic-Beads-Based Digital Microfluidic Immunoassay
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Wensyang, Hsu, Yu-Teng, Shih, Meng-Shiue, Lee, Hong-Yuan, Huang, and Wan-Ning, Wu
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Immunoassay ,Immunomagnetic Separation ,Magnetic Phenomena ,Microfluidics ,Clinical Biochemistry ,General Medicine ,Immunologic Tests ,magnetic beads ,droplet-based microfluidics ,immunoassay ,coefficient of variation - Abstract
In a biomedical diagnosis with a limited sample volume and low concentration, droplet-based microfluidics, also called digital microfluidics, becomes a very attractive approach. Previously, our group developed a magnetic-beads-based digital microfluidic immunoassay with a bead number of around 100, requiring less than 1 μL of sample volume to achieve a pg/mL level limit of detection (LOD). However, the bead number in each measurement was not the same, causing an unstable coefficient of variation (CV) in the calibration curve. Here, we investigated whether a fixed number of beads in this bead-based digital microfluidic immunoassay could provide more stable results. First, the bead screening chips were developed to extract exactly 100, 49, and 25 magnetic beads with diameters of less than 6 μm. Then, four calibration curves were established. One calibration curve was constructed by using varying bead numbers (50–160) in the process. The other three calibration curves used a fixed number of beads, (100, 49, and 25). The results indicated that the CVs for a fixed number of beads were evidently smaller than the CVs for varying bead numbers, especially in the range of 1 pg/mL to 100 pg/mL, where the CVs for 100 beads were less than 10%. Furthermore, the calculated LOD, based on the composite calibration curves, could be reduced by three orders, from 3.0 pg/mL (for the unfixed bead number) to 0.0287 pg/mL (for 100 beads). However, when the bead numbers were too high (more than 500) or too low (25 or fewer), the bead manipulation for aggregation became more difficult in the magnetic-beads-based digital microfluidic immunoassay chip.
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- 2022
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9. Wide-temperature antifouling characteristic of a double re-entrant pillar array surface
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Meng Shiue Lee, Ming-Chang Lu, Ching Wen Lo, Wensyang Hsu, and Chung Te Huang
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Fluid Flow and Transfer Processes ,Surface (mathematics) ,Materials science ,Fouling ,Silicon dioxide ,Mechanical Engineering ,Pillar ,02 engineering and technology ,Atmospheric temperature range ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Superhydrophobic coating ,010305 fluids & plasmas ,Biofouling ,chemistry.chemical_compound ,chemistry ,Impurity ,0103 physical sciences ,Composite material ,0210 nano-technology - Abstract
Fouling causes numerous adverse effects on various types of systems. In addition, clean fouling on a solid surface is cost-intensive and time-consuming. Superhydrophobic (SHB) surfaces with a water-repellent property can potentially be used for antifouling. However, SHB surfaces lose their antifouling property at high temperatures because of the failure of the hydrophobic coating on them. Nevertheless, there are numerous applications being operated at high temperatures. Thus, a surface exhibiting antifouling characteristic over a wide temperature range is required. In this study, we demonstrate that a double re-entrant pillar (DRP) array surface possesses a wide-temperature antifouling characteristic. Although the silicon dioxide top surface of the pillar is hydrophilic, the upward surface tension force from the DRPs prevents the impacting droplets from penetrating the pillar array. Thus, the impacting droplets bounce back from the surface without leaving residues on it at temperatures from 25 to 560°C. By contrast, the impurities of the impacting droplets are retained on an SHB surface composed of a silicon nanowire array at various temperatures. The wide-temperature antifouling property of the DRP surface can be used for preventing fouling in many industrial systems.
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- 2021
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10. An EWOD-based micro diluter with high flexibility on dilution ratio
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Cheng Yeh Huang, Jun Hao Huang, Meng Shiue Lee, Wensyang Hsu, Ying Bin Wang, Yung Yi Tu, Ichiro Yamashita, and Cheng-Sheng Huang
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Flexibility (engineering) ,Chromatography ,Chemistry ,010401 analytical chemistry ,Analytical chemistry ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,0104 chemical sciences ,Electronic, Optical and Magnetic Materials ,Dilution ,Dilution ratio ,Microfluidic chip ,Hardware and Architecture ,Electrode ,Electrical and Electronic Engineering ,0210 nano-technology ,Droplet size ,Volume concentration - Abstract
Dilution is a common procedure in biological and chemical analyses to perform tests at different concentrations. In previously reported micro diluters, although they could provide a wide dilution range, only limited dilution ratios were demonstrated, i.e. low flexibility in dilution ratio. Here, a droplet-based micro diluter with high flexibility on dilution ratio is proposed, fabricated, and tested. Through combination of five different electrode sizes using electrowetting-on-dielectric (EWOD) technique, the proposed micro diluter can provide 49 dilution ratios at dilution range from 1/2 to 1/50. Experimental results verify that different dilution ratios can be successfully generated, even at the most difficult low concentration range. Comparing to the design with equal electrode size in conventional EWOD-based microfluidic chip, the proposed design with unequal electrode sizes can reduce the operation steps to achieve high flexibility on dilution ratios efficiently.
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- 2016
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11. A Resettable, Wireless and Passive Fall-Down Recorder Using a Magnetic Droplet With an <tex-math notation='LaTeX'>$LC$ </tex-math> Circuit
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Cheng-Yeh Huang, Yi-Chueh Shieh, Meng-Shiue Lee, Sung-Yueh Wu, Peng Sun, and Wensyang Hsu
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Engineering ,Microchannel ,business.industry ,010401 analytical chemistry ,Electrical engineering ,02 engineering and technology ,LC circuit ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Acceleration ,Transmission (telecommunications) ,Magnet ,Fictitious force ,Electrical and Electronic Engineering ,0210 nano-technology ,business ,Instrumentation ,Reset (computing) ,Wireless sensor network - Abstract
A fall-down recorder can record the happening of an object falling down during object delivery or transportation, even after the object is recovered to its initial state. Here, a resettable, wireless and passive fall-down recorder is proposed by integrating a droplet-based inertial force switch with the inductor–capacitor ( $LC$ ) circuit for wireless signal transmission. A magnetic droplet is used in the switch with a converging microchannel to control the desired threshold acceleration. When the inertial force exceeds the designed threshold acceleration, the magnetic droplet will pass through the converging microchannel to a deep cavity to become a different state. By connecting the switch with the sensing $LC$ circuit, the state of the recorder can be wirelessly identified through the $LC$ resonant frequency. After triggering, this switch can be remotely reset to its initial state by an external magnet. A proper hydrophobic surface treatment is employed to facilitate the movement of the magnetic droplet and reduce the variation on the threshold acceleration. The capabilities, including switching, recording, wireless reading, and resetting of the proposed fall-down recorder, are successfully designed, fabricated, and verified with ten recording-reset tests.
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- 2016
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12. Detection of Multiple Embryo Growth Factors by Bead-Based Digital Microfluidic Chip in Embryo Culture Medium
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Chia-Tung Lee, Cheng-Yeh Haung, Hsueh-Yang Tseng, Meng-Shiue Lee, Yi-Ting Jiang, and Wensyang Hsu
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Ivf treatment ,Detection limit ,Chromatography ,Materials science ,medicine.diagnostic_test ,Rapid immunoassay ,Calibration curve ,010401 analytical chemistry ,Embryo ,Embryo culture ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Microfluidic chip ,Immunoassay ,medicine ,0210 nano-technology - Abstract
In IVF treatment, the pregnancy rate of selective single embryo implantation can be improved by detection the concentration of embryo growth factors such as $\mathbf{IL} -1\beta$ and $\mathbf{TNF}-\alpha$ in embryo culture medium. In this study, we manufacture the high dielectric constant digital microfluidic chip and develop a Bead-based digital microfluidic immunoassay with low sample requirement, low limit of detection and rapid immunoassay. We establish the mouse $\mathbf{TNF} -\alpha$ calibration curve and the requirement of sample is 520 nL, limit of detection is 1.55 pg/mL and total immunoassay time is 27 min. We also establish the Human $\mathbf{IL} -\mathbf{1\beta}$ calibration curve and the requirement of sample is 520 nL, limit of detection is 0.0579 pg/mL and total immunoassay time is 21 min.
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- 2018
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13. An Implantable Drug-delivery System on a Chip
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Da-Jeng Yao, Wensyang Hsu, and Meng Shiue Lee
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Microelectromechanical systems ,Flexibility (engineering) ,business.industry ,Computer science ,Microfluidics ,General Medicine ,Microfluidic Analytical Techniques ,Chip ,Drug Delivery Systems ,Embedded system ,On demand ,Drug Discovery ,Drug delivery ,Hardware_INTEGRATEDCIRCUITS ,Animals ,Humans ,Nanotechnology ,System on a chip ,Delivery system ,business - Abstract
An implantable system for drug delivery provides a new strategy for drug therapy, and typically involves a microfluidic chip produced with micro or nano-technology. Implantable systems have the flexibility to conform various schemes of drug release, including zero order, pulsatile, and on demand dosing, as opposed to a standard sustained release profile. Such an implantable system is classified as allowing either controllable or uncontrollable drug release after implantation, so an active or passive delivery system respectively. The performance and related applications of these systems vary. The key points of each technology are highlighted such as performance, working principle, fabrication methods, and dimensional constrains. We here review the implantable drug-delivery system in current research with a focus on application and chip performance, and comparison for passive and active delivery system.
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- 2015
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14. Bead-based digital microfluidic immunoassay for IL-1β detection in embryo culture medium
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Da-Jeng Yao, Yi-Ting Jiang, Meng-Shiue Lee, Cheng-Yeh Huang, Hsueh-Yang Tseng, and Wensyang Hsu
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Detection limit ,Pregnancy ,Materials science ,medicine.diagnostic_test ,010401 analytical chemistry ,Microfluidics ,Small sample ,Embryo culture ,Embryo ,02 engineering and technology ,021001 nanoscience & nanotechnology ,medicine.disease ,01 natural sciences ,Molecular biology ,0104 chemical sciences ,Andrology ,Pregnancy rate ,Immunoassay ,embryonic structures ,medicine ,0210 nano-technology - Abstract
One of the challenges in IVF treatment is to improve the pregnancy rate of selective single embryo implantation. The concentration of IL-1β in embryo culture medium may help to predict pregnancy rate. Clinically, each embryo can only get small amount of sample size. However, the traditional immunoassay cannot detect biomarkers in such small sample sizes. Therefore, we combined immunoassay with the bead-based digital microfluidic chip. The chip has two advantages, low sample requirement and low detection limit. We established the mouse IL-1β calibration curve, confirm the Human Tubal Fluid (HTF) does not influence the test result and demonstrate that mouse IL-1β in clinical mouse embryo culture medium is positively correlate to cultured days. This device has a great potential for increasing IVF pregnancy rates.
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- 2017
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15. Passive and wireless strain sensor based on LC circuit with lamination fabrication
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Wensyang Hsu, Cheng Tu, Meng-Shiue Lee, and Chin-Liang Liu
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Antenna analyzer ,Materials science ,business.industry ,010401 analytical chemistry ,Electrical engineering ,Integrated circuit ,LC circuit ,01 natural sciences ,0104 chemical sciences ,law.invention ,010309 optics ,law ,Power module ,visual_art ,0103 physical sciences ,Electronic component ,visual_art.visual_art_medium ,Wireless ,Torque ,business ,Wireless sensor network - Abstract
From traditional manufacturing to integrated circuit technology, shaft components have been utilized in different kinds of industries. Therefore, torsion monitoring to maintain the precision of machines is an important task. However, in order to check the performance, the shaft component needs to be dismounted from working position and installed in an expensive testing system for further diagnoses, which is labor-consuming and inefficient. In this study, we proposed a passive, wireless smart LC sensing tag based on the developed LC technology produced by commercial aluminum foil lamination and fast slitting techniques. With this smart tag fixed on the shaft, the torque generated by the system can be monitored, since the resonance frequency, shifting accordingly to the change of torque, can be readable by RF coils' inducting. Therefore, the smart LC sensing tag can work wirelessly and passively without physically connecting to a battery or power module. The goal of this study is to monitor stress at least 0.0056e by using the portable antenna analyzer which has the resolution about 1.3113MHz/e. This technology has the great vision that applies to the shaft monitoring in vehicles or fabrication machines. Furthermore, it can be integrated into IOT application.
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- 2017
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16. Fabrication of a transparent structured superomniphobic surface using a multiple partial expose method
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Wensyang Hsu, Meng-Shiue Lee, and Po-Han Wu
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Surface (mathematics) ,Surface tension ,Silicon oil ,Materials science ,Fabrication ,Resist ,Nanotechnology ,Substrate (printing) ,Wetting ,Lithography - Abstract
A novel approach which uses a multiple partial exposure method to fabricate a transparent structured superomniphobic surface with doubly re-entrant structures by using negative thick photoresist SU-8 as the material is proposed. By using gray-tone lithography, the doubly re-entrant structures can be formed only via a standard lithography process. The gray-tone lithography for fabricating the doubly re-entrant structures is achieved by depositing three appropriate thicknesses of Ti film on glass substrate that acts as the gray-tone mask. The proposed transparent surface with the doubly re-entrant structures successful suspend all the tested liquid even the completely wetting liquid, such as silicon oil with the surface tension of 20.9 mN/m. This approach provides a simple, flexible and low-cost solution for fabricating superomniphobic surface, and it also has the potential to integrate with either flexible or nonflexible substrate for different applications.
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- 2017
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17. Electromagnetic/Magnetic-Coupled Targeting System for Screw-Hole Locating in Intramedullary Interlocking-Nail Surgery
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Hou Jen Chu, Tzu Wei Liu, Wensyang Hsu, Chin Chung Chen, Meng Shiue Lee, Tze-Hong Wong, Po Chen Yeh, Yuh-Shyong Yang, and Tien-Kan Chung
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medicine.medical_specialty ,Materials science ,Medullary cavity ,Electromagnet ,equipment and supplies ,Magnetic flux ,Surgery ,Electromagnetic induction ,law.invention ,Intramedullary rod ,Fixation (surgical) ,Electromagnetic coil ,law ,medicine ,Electrical and Electronic Engineering ,Instrumentation ,Interlocking ,Biomedical engineering - Abstract
At present, intramedullary interlocking nails are widely used for bone-fracture fixation in orthopedic surgeries. Surgeons often use X-ray imaging to find the actual location of the distal screw-holes of the nail after the nail is inserted into the medullary canal of a bone for fixation. Thus, the patients and medical team are inevitably exposed to radioactivity. In this paper, we report a radiation-free electromagnetic/magnetic- coupled targeting system to locate the distal screw-holes of the nail used in interlocking-nail surgery. The targeting system consists of a c-shaped electromagnet with a pick-up coil, a highly permeable curved silicon-steel strip embedded on the nail, a guiding mechanism, and electronic measuring instruments. An alternative current is applied to the electromagnet to generate a uniform magnetic field/flux in the electromagnet's air gap. When the nail inserted into the medullary canal of a bone is scanned through or rotated in the air gap of the electromagnet, the magnetic flux in the air gap is influenced by the silicon-steel strip embedded on the nail. The variation of the magnetic flux induces a voltage response in the pick-up coil due to electromagnetic induction. The pattern of the voltage response is analyzed to establish a criterion for screw-hole targeting. The results obtained using this criterion reveal that the maximum targeting error of the location and orientation targeting for a screw-hole with a diameter of 5 mm is
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- 2014
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18. Electromagnetic coil/inductance-based nondestructive methods for locating distal screw-holes of an intramedullary interlocking-nail
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Wensyang Hsu, Tien-Kan Chung, Hou Jen Chu, Meng Shiue Lee, Ya Wen Cheng, and Tze-Hong Wong
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Intramedullary rod ,Inductance ,Search coil ,Materials science ,law ,Magnetism ,Electromagnetic coil ,Acoustics ,Physics::Medical Physics ,Magnetic flux ,Electromagnetic induction ,law.invention ,Voltage - Abstract
We report an electromagnetic inductance/coil-based non-destructive method to target distal screw-holes in an intramedullary interlocking-nail surgical operation for fixing a long-bone fracture. The method is a radiation-free approach addressing the over-exposure issue of radioactivity caused by the typical X-ray-imaging approach. According to the method, we fabricate a targeting-system consisting of an internal inductance, external coil, guiding-mechanism, and driving/measurement electronics. When a voltage is applied to the internal inductance embedded in one of the distal screw-holes of a nail inserted in a bone, a directional magnetic flux is generated by the internal inductance due to the electromagnetic induction. Subsequently, the directional magnetic flux penetrates the nail and bone. When the external coil outside the bone scans along the axial and angular directions of the nail/bone, different amount of the generated magnetic flux is detected by the coil and consequently corresponding voltage response is induced in the coil due to the electromagnetic induction. In contrast to the magnetic flux generated and detected by the inductance and coil, respectively, we also investigate the reverse physics-behavior of the flux transmission (i.e., flux generated and detected by the coil and inductance) in order to improve the approach. Finally, by correlating the induced-voltage responses with the scanned axial-locations along the nail/bone, correlation curves are plotted. Through analyzing the curves, a criterion for predicting the location of the screw-holes of the nail is established. When compared the predicted location with the actual location of the screw-hole, the maximum targeting error is 2 mm for locating a screw-hole with a diameter of 5 mm. The result shows the targeting-method is accurate, fast, and easy for the surgeons and significantly simplifies the existed interlocking-nail surgical procedures.
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- 2013
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19. A novel guiding device for distal locking of intramedullary nails
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Tien-Kan Chung, Wensyang Hsu, Meng-Shiue Lee, Sung-Yueh Wu, and Tze-Hong Wong
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Intramedullary rod ,Materials science ,business.industry ,law ,Magnet ,Electrical engineering ,Nail (fastener) ,Mechanical engineering ,Biomedical equipment ,business ,Electrical conductor ,law.invention - Abstract
This paper presents the prototype of a new remote guiding device to find the accurate screw hole position for drilling and direction for locking in intramedullary nailing surgery. The device consists of three magnetic pins and an electrical conductive board. The three symmetrically placed magnetic pins can rotate freely and point to the permanent magnet inside the nail. The drilling position and screwing direction can be obtained by moving the device with those magnetic pins to align with the magnet in the nail. The alignment condition is indicated by a LED. When the device is not aligned with the magnet in the nail properly, either in position or direction, the pins then will contact with the board to trigger a light-emitting diode for alarming.
- Published
- 2012
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20. An electromagnetic-induction approach for screw-hole targeting in interlocking-nail surgery
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Hou-Jen Chu, Meng-Shiue Lee, Wensyang Hsu, Chia-Yuan Tseng, Tze-Hong Wong, Tien-Kan Chung, and Wen-Tuan Lo
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medicine.medical_specialty ,Materials science ,Electromagnet ,Physics::Medical Physics ,Magnetic flux ,law.invention ,Electromagnetic induction ,Surgery ,Intramedullary rod ,law ,Permeability (electromagnetism) ,Electromagnetic coil ,medicine ,Air gap (plumbing) ,Voltage ,Biomedical engineering - Abstract
We report a novel approach for targeting screw-holes of an intramedullary nail in a long-bone fracture surgery. The approach utilizes the electromagnetic induction to avoid over exposure of radioactivity which is the critical issue in conventional X-ray-imaging targeting method. Based on the approach, we fabricate a targeting system. The targeting system consists of a c-shaped electromagnet, detecting-coil, guiding-mechanism, and measurement electronics. When a voltage is applied to the electromagnet, magnetic flux is generated in the air gap of the electromagnet and subsequently detected by the coil. When the flux is detected by the coil, a voltage response is induced in the coil. When a nail in a bone is scanned through the air gap of the electromagnet, the flux is influenced due to a discrepancy of the permeability between the location with and without the hole of the nail. The influenced flux induces different voltage response in the coil. Through analyzing the voltage response, we establish a criterion for targeting the holes. By the criterion, the experimental result shows the maximum error of targeting a hole with a diameter of 5 mm is less than 2.5 mm.
- Published
- 2012
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