1. Cancer chemopreventive constituents from Melicope lunu-ankenda
- Author
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Hugh T. W. Tan, Chihiro Ito, Masataka Itoigawa, Harukuni Tokuda, and Takuya Matsui
- Subjects
biology ,010405 organic chemistry ,Stereochemistry ,Plant Science ,Umbelliferone ,Marmesin ,biology.organism_classification ,Coumarin ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,Benzaldehyde ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,Melicope lunu-ankenda ,Early antigen ,Melicope ,Rutaceae ,chemistry ,Agronomy and Crop Science ,Biotechnology - Abstract
A study of the chemical constituents obtained from twigs of Melicope lunu-ankenda (Gaertn.) T.G. Hartley (Rutaceae) led to the isolation and structure elucidation of two new coumarins, 7-(4-hydroxy-3-methylbutanoxy) coumarin and 7-(3-methyl-4-carboxybutanoxy) coumarin methyl ester, named melilunumarin A ( 1 ) and melilunumarin B ( 2 ), respectively. A new benzaldehyde derivative, 3,4-dihydro-3,4-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-carboxaldehyde, named melilunumane ( 6 ), was also isolated and characterized, as well as five previously reported compounds, 6-deoxyhaplopinol ( 3 ), marmesin ( 4 ), umbelliferone ( 5 ), kokusaginine ( 7 ) and evolitrin ( 8 ). Among the five isolated coumarins, melilunumarin A ( 1 ), 6-deoxyhaplopinol ( 3 ) and marmesin ( 4 ) exhibited significant inhibitory activity towards Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol 13-acetate in Raji cells.
- Published
- 2017
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