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The goal of this project is to assess the believability and impact of the news article manipulation in our group categorization study

Dopamine, oxytocin, serotonin, and endorphins (DOSE) are a collection of neurotransmitters often represented in media as uniquely responsible for health, happiness, and well-being. Very often, these statements uncritically create overly-simplistic relationships between neurotransmitter release and psychological constructs of pleasure, joy, love, and happiness. There is evidence of a "seductive allure" of neuroscience, such that explanations of mental states or behavioral phenomena are rated more satisfactory if they contain irrelevant references to brain activity. However, some studies find this effect to be weak or non-existent. We propose that, due to its ubiquity, DOSE information may be not only more satisfying, but more persuasive to change behavior. Furthermore, we seek to identify subpopulations that may be more susceptible to such information, especially those with familiarity with the DOSE substances, or for whom media reports of these neurotransmitters may be more salient.

Social psychology finds that people think about, and treat, others differently, depending on whether they are in their in-group or out-group. Less is known about whether we judge the actions and intentions of in-group members better than the same actions taken by those in out-groups. Participants will be given a variety of scenarios written as news stories, which present certain actors as members of their in-group or out-group. There will also be neutral versions, in which group membership is ambiguous. Groupings are varied across scenarios basis of race, nationality, college, or politics. We already have data from an initial study involving slightly different scenarios. This study was not registered, but the full data set is available at https://osf.io/5tuqz/ . Briefly, we found that people often do judge actions to be more morally acceptable or permissible if undertaken by an in-group member. However, there were fewer differences in judging the motives behind the actions of other in-group or out-group members.

The COVID-19 pandemic has necessitated a move to online learning. Many classes are being taught remotely, that would otherwise be taking place in traditional classrooms. While the effectiveness of online teaching methods is secondary to safety concerns, it should not be ignored. Previous research indicates, for instance, that videos receive higher satisfaction ratings if they include a small video of the narrator speaking, compared with audio narration without video of the speaker's head and upper body. We seek to determine whether including a video avatar of a speaker would lead to not only greater satisfaction with the video (compared with voice-over narration and a non-narrated slide deck condition), but greater retention of material

With the proliferation of neuroscience-related messages in popular media, it is more important than ever to understand their impact on the lay public. Previous research has found that people believed news stories more when irrelevant neuroscientific explanations were added. We sought to reveal whether such information could cause a change in social behavior. Specifically, based on publicized findings of the relationship between social behavior and the neurotransmitter oxytocin, we proposed that participants would accept more strangers into their in-group, or alternatively decrease in-group size, if told that there were oxytocin-based (relative to psychological construct-based) health benefits for doing so. In two tasks, participants were shown faces and written information about stimuli that could match their race, politics, and religion to varying degrees. In spite of evidence that participants processed the primes, and were sensitive to their level of similarity with stimuli, oxytocin-based priming did not alter categorization, or pupil dilation. It did not alter cross-race viewing behavior, as measured by an eye tracker, in consistent ways. Unexpectedly, pupil dilation increased when viewing stimuli of the same religion, an effect entirely related to White liberal Christians viewing other Christians. Overall, these results suggest that neuroscience information may impact some judgments, but lay people will not alter their likelihood of acceptance of strangers simply because they were primed with a neuroscience- (or more specifically, neurotransmitter-) based reason for doing so.

Abstract 3510 Background: The outcome in FL pts relapsing after ASCT has not been well studied. While the use of nonmyeloablative allogeneic stem cell transplantation (NST) has been promising in this setting, one could not underestimate the results of selective inclusion criteria. Methods: All patients with FL who experienced a relapse after ASCT at The University of Texas M. D. Anderson Cancer Center between 1997 (the initiation of the rituximab and NST era) and 2007, were analyzed. Results: Fifty pts were identified. Fifteen (30%) pts underwent NST after ASCT relapse (Group A); 25 (50%) pts (Group B) met the eligibility criteria for NST but were not allotransplanted due to either physician/pt preference (n=14), lack of suitable donors (n=5), insurance requirements (n= 3), other causes (n=3). Ten (20%) pts (Group C) were not eligible for NST due to refractory disease or co-morbidities. At the time of progression after ASCT, the comparison of pts who were considered for NST showed that Group A pts and Group B pts had a comparable age [median 57 years(range, 45–64) vs 58 years (range, 40–70), p=0.7, respectively], serum LDH level (p=0.1), # of extranodal sites of disease (p=0.4), marrow involvement (p=0.1), and stage III/IV (p=0.2). The histology subtypes were also equally distributed in both groups (FL grades 1, 2, and 3 were found in 27%, 40% and 30% of Group A pts, respectively, and in 16%, 44% and 40% of Group B pts, respectively). The majority of pts in Groups A and B had a good ECOG PS of 0–1 (100% vs 96%, respectively). The median time from ASCT to progression was 16 months (range, 4–42) in Group A, and 19 months (range, 3–99) in Group B. Group A pts underwent their NST at a median of 8 months after their ASCT relapse. At their progression post ASCT, pts in Group B were treated with either rituximab as a single agent (n=12, 48%), or combination chemo-antibodies (n=7, 28%); the therapy received in the remaining 6 (24%) pts was unknown. With a median follow-up time of 49 months (range 23–113 months) for Group A, and 37 months (range, 17–130 months) for Group B, the actuarial survival rates at 4-year were 73%(%95 CI, 42–89) and 71% (%95 CI, 46–86), respectively, (Figure, p = 0.9). The causes of death in Group A were related to infection (1), organ failure (1), progression (2), and unknown (1). Five pts in Group B died of progression and one died of secondary leukemia. Pts in Group C had a median survival time of 7 months; only 2 pts of this group were still alive at the time of this analysis was made. Conclusions: Single institution results show that 30% of pts with FL relapsing after ASCT undertook an allotransplant. While allogeneic NST is an effective therapy for these pts, a significant proportion of pts can be observed for several years before an allotransplant should be considered. Disclosures: No relevant conflicts of interest to declare.