2,879 results on '"McClean A"'
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2. Clinical features and management of individuals admitted to hospital with monkeypox and associated complications across the UK: a retrospective cohort study
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Douglas L Fink, Helen Callaby, Akish Luintel, William Beynon, Helena Bond, Eleanor Y Lim, Effrossyni Gkrania-Klotsas, Jospeh Heskin, Margherita Bracchi, Balram Rathish, Iain Milligan, Geraldine O'Hara, Stephanie Rimmer, Joanna R Peters, Lara Payne, Nisha Mody, Bethany Hodgson, Penny Lewthwaite, Rebecca Lester, Stephen D Woolley, Ann Sturdy, Ashley Whittington, Leann Johnson, Nathan Jacobs, John Quartey, Brendan AI Payne, Stewart Crowe, Ivo AM Elliott, Thomas Harrison, Joby Cole, Katie Beard, Tomas-Paul Cusack, Imogen Jones, Rishi Banerjee, Tommy Rampling, Jake Dunning, Iain D Milligan, Alison J Rodger, Sanjay R Bhagani, Lucy E Lamb, Rachel C Moores, Simon F K Lee, Colin S Brown, Susan Hopkins, Stephen Mepham, Simon Warren, Aoife Molloy, Ian Cropley, Alex Kew, Natasha Karunaharan, Antonia Scobie, Jennifer Hart, Dianne Irish, Tanzina Haque, Hamid Jalal, Robin Smith, Damien Mack, Tristan Barber, Fiona Burns, Robert Miller, Eleanor Hamlyn, Pedro Simoes, Breda Athan, Jennifer Abrahamsen, Jessica Joyce, Caroline Taylor, Sally Reddecliffe, Chloe Miller, Brooke Reeve, Hugh Kingston, Tim Crocker-Buque, Nicolas Massie, Ankush Dhariwal, Angelina Jayakumar, Robert Hammond, Alexandra Bramley, Tanmay Kanitkar, Laura Maynard-Smith, Eliza Gil, Cavan O'Connor, Derek Cocker, Wendy Spicer, Marisa Lanzman, Meera Thacker, Zoe O Anorson, Dharmesh Patel, Alan Williams, Catherine F Houlihan, Dominic Wakerley, Claire N Gordon, Daniel J Bailey, Jenna Furneaux, Abbie M Bown, Elizabeth J Truelove, Marian J Killip, David Jackson, Tracy L B Beetar-King, Ulrike M V Arnold, Rhea M Strachan, Jones Matthew, Hannah J Matthew, Jane C Osborne, Richard Vipond, Barry Gibney, Jodie Owen, Will Beynon, Michael Hunter, Louise McCorry, Carol Emerson, Say Quah, Suzanne Todd, Emma McCarty, Eoin Walker, Susan Feeney, Tanya Curran, Kathy Li, JD Mullan, Kate Jackson, Peter Nelson, Kevin Lewis, Mark McNicol, Marcus Pratt, Anna Smith, Erin Vos, Fahad Alsalemee, Daniel O Leary, John Canny, Katherine McGinnity, Carly Culbert, Conor McDowell, Cathy McQuillan, Eunjin Jeong, Lynsey Glass, Jessica Dyche, Paula McClean, Rebecca Stewart, Harold Ursolino, Melissa Perry, Hannah McCormick, Joseph Heskin, Nicklas Brown, Thomas Juniper, Borja Mora-Peris, Alessia Dalla-Pria, Nicola Mackie, Lucy Garvey, Alan Winston, Graham Cooke, Mark Nelson, Emer Kilbride, Ala Elbishi, William Kerrigan, Joshua Silva, Jesal Gohil, Sasha Payagala, Yasmin Walters, Joanna Smith, Jonathan Goodfellow, Kitty Lyons, Hsiu Tung, Kinjal Patel, Merle Henderson, Michael Butler, Edu Peres, Taiana Silva Carvalho, Antoine Joly, Molly Dickinson, Luke S P Moore, Nabeela Mughal, Stephen Hughes, Shrada Chitlangia, Priyanka Viramgana, Ruth Byrne, Paul Randell, Luigi Strangis, Nicola Poveda, Deborah Bovey, Poppy Richardson, Vivian Heaslip, Christopher Higgs, Marta Boffito, Nicolo Girometti, Gary Whitlock, Victoria Tittle, Rachel Jones, Michael Rayment, Christopher Scott, David Asboe, Marcus Pond, David Muir, Movin Abeywickrema, Sarah-Lou Bailey, Sara E Boyd, Dayana Da Silva Fontoura, Anna Daunt, Claire Y Mason, Jamie Murphy, Vasanth V Naidu, Aatish Patel, Caitlin Pley, Ethan Redmore, Katherine Sharrocks, Luke B Snell, Rohan Sundramoorthi, Jerry C H Tam, Aisling Brown, Sam Douthwaite, Anna Goodman, Gaia Nebbia, William Newsholme, Nicholas Price, Emily Shaw, Alex Salam, Claire van Nispen tot Pannerden, Helen Winslow, Julia Bilinska, Sarah Keegan, Harry Coleman, Jessica Doctor, Nasreen Moini, Daniella Chilton, Golaleh Haidari, Rebecca Simons, Rajababu Kulasegaram, Nick Larbalestier, Achyuta Nori, Jack R Potter, Cecilia Tuudah, Paul Wade, Alexandra Travers, Sarah Dunford, Joshua Greenwood, Georgina Oledimmah, Lesley Gyampo, Pedro SA Pinto, AbdulKadir Muse, Zoe Parker, Charlotte Alexander, Alexander Khan, Medinat Ajayi, Abigail Baltazar, Davis Sharella, Nasra Hersi, Thuy Nguyen, Rugiatu Timbo, Ismail Jalloh, Susan Bryan, Patricia Clarke, Marcia Kerr, Fidelis Amedu, Maria BohoBonaba, Sarah Haque, Michelle Howson, Norbai Tambilawan, Soledad Yupanqui Estay, Hawanatu Bangura, Tseday Gideon, Damilola Jerome-oboh, Linda Tetteh, Chioma Nwagu, Viwoalo Agbaglah, Nona Narag, Mahima Zaveri, Maedhbh Ni Luanaigh, Peggy Keane, Aula Abbara, Olamide Dosekun, Mhairi Bolland, Adam Stafford, Dina Saleh, Rhianna Sheridan, Ella Davies, Kristi Sun, Mark Gilchrist, Priti Kukadia, Muhammed Embrahimsa, Christopher Chiu, Lauren Taylor, Charlotte Short, Jasmini Alagratnam, Iresh Jayaweera, Kavitha Gundugola, Lara V S Payne, Killian Quinn, Caoimhe Nic Fhogartaigh, Nivenjit Kaur, Salmaan Bholah, Kajann Kantha, Jonathan Youngs, Temi Lampejo, Nicholas Pitto, David S Lawrence, Holly Middleditch, Lourdes Dominguez-Dominguez, Ayoma Ratnappuli, Sara Al-Hashimi, Amelia Oliveira, Zoe Ottaway, Larissa Mulka, Anne M Neary, Michael R Downey, Danielle C Lucy, Craig I McCallum, Michael Beadsworth, Libuse Ratcliffe, Tom E Fletcher, Gerry Davies, Nicholas Wong, Stephen Aston, Thomas E Wingfield, Thomas Blanchard, Paul Hine, Susie Gould, Christopher Smith, Michael Abouyannis, Abolaji Atomode, James Cruise, Merna Samual, Nicola Scott, Vino Srirathan, Joseph Lewis, Lauren Richards, Mary-Ann Cummings, Emily Gillan, Rebecca Peers, Amy Tickle, Grace Keating, Tendi Chinyanda, Mav Sanchez, Daniel Harrison, null Hoyle, Ben Metcalfe, Jennifer Taylor, Nicky Johnson, Neil Kelle, Kirsty McDowell, Ian Richardson, Monette Saguidan, Nicky Farmer, Angella Gillespie, Shay Willoughby, Samantha Parker, Shamseena Avulan, Shazia Arif, Suzanne Marshall, David Carlisle, Mohsen Rezaei, Angela Booth, Joanne Watts, Lauren Tremarco, Priyanga Jeyanayagam, Odinaka Ubochi, Daniel Vagianos, Mark Richardson, Anthony Jarvis, Kyra Gow, Jade Walmsley, Adam O'keefe, Anna Smielewska, Mark Hopkins, Fatima Balane, Sarah Bradley, Tumena Corrah, Venus Daquiz, Christopher Dugan, Joshua Elliot, Fiona Foley, Dawn Friday, May Gamit, David Garner, Karishma Gokani, Laurence John, Deepa Joseph, Nuzhath Khan, Cherifer Mamuyac, Alastair McGregor, John McSorley, Victoria Parris, Luciana Rubinstein, Julian Rycroft, Kelcy Salinas, Jason Salinas, Jency Sebatian, Melanie Smith, Marina Tejero Garcia, Uchenna Ume, Margarete Vicentine, Gabriel Wallis, Alec Bonington, Alison Uriel, Andrew Ustianowski, Balazs Dancso, Celia Hogan, Clare van Halsema, F Javier Vilar, Karen Devine, Katherine Ajdukiewicz, Rajesh Rajendran, Samit Ghosh, Michael Riste, Nicholas Machin, Chitra Babu, Shazaad Ahmad, Dorcas Obeng, Farnaz Dave, Gavin Conolley, Joseph Thompson, Maya Tickell-Painter, Prasun Chakravorty, Rachel Pringle, Mohammad R Zafar, Sarah Lawrence, Amada Sanchez-Gonzalez, Cristina Fernandez, Lynsey Goodwin, David Carey, Molly Howarth-Maddison, Samuel Moody, Rebecca Upton, Christina Apthorp, Charlotte Murray, Kirstie Salthouse, Sabah Nadeem, Grant Ridley, Francesca White, Andrew Brown, Michael Lawless, Mohamed Mohamed, Robert Mulligan, Amy Belfield, Jacob Brolly, Maria Calderon, James Cheveau, Milo Cullinan, Sophie Garrad, Will Griffiths, Aidan Ireland, Peter Ireland, Charlotte Milne, Paul Nwajiugo, Bijan Ghavami-Kia, Chris Duncan, Adam Evans, Ewan Hunter, Ashley Price, Matthias Schmid, Uli Schwab, Yusri Taha, Brendan Payne, Ivo A M Elliott, Charles J Woodrow, Drosos E Karageorgopoulos, Peter J Davis, Emily Lord, Oliver J Bannister, Andrew B Dagens, Anne Tunbridge, Saher Choudry, Adam Telfer, Ihsan Jhibril, Syed N Atta, Ben Stone, Cariad Evans, Mike Ankcorn, Suha Akili, Mehmet Yavuz, Vicky Goodall, Sam Farrow, Georgina Mountford, Kate Beard, Julian Sutton, Tristan Clark, Annette Mason, Mike Vickers, Derek Macallan, Tihana Bicanic, Angela Houston, Cassie Pope, NgeeKeong Tan, Christopher Ward, Jonathan Cohen, Marieke Emonts-le Clercq, David Porter, Andrew Riordan, Ruchi Sinha, Elizabeth Whittaker, and Monkeypox, Specialist and High Consequence Infectious Diseases Centres Network for
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Infectious Diseases - Abstract
Background:The scale of the 2022 global mpox (formerly known as monkeypox) outbreak has been unprecedented. In less than 6 months, non-endemic countries have reported more than 67 000 cases of a disease that had previously been rare outside of Africa. Mortality has been reported as rare but hospital admission has been relatively common. We aimed to describe the clinical and laboratory characteristics and outcomes of individuals admitted to hospital with mpox and associated complications, including tecovirimat recipients. Methods:In this cohort study, we undertook retrospective review of electronic clinical records and pathology data for all individuals admitted between May 6, and Aug 3, 2022, to 16 hospitals from the Specialist and High Consequence Infectious Diseases Network for Monkeypox. The hospitals were located in ten cities in England and Northern Ireland. Inclusion criteria were clinical signs consistent with mpox and MPXV DNA detected from at least one clinical sample by PCR testing. Patients admitted solely for isolation purposes were excluded from the study. Key outcomes included admission indication, complications (including pain, secondary infection, and mortality) and use of antibiotic and anti-viral treatments. Routine biochemistry, haematology, microbiology, and virology data were also collected. Outcomes were assessed in all patients with available data. Findings:156 individuals were admitted to hospital with complicated mpox during the study period. 153 (98%) were male and three (2%) were female, with a median age of 35 years (IQR 30–44). Gender data were collected from electronic patient records, which encompassed full formal review of clincian notes. The prespecified options for data collection for gender were male, female, trans, non-binary, or unknown. 105 (71%) of 148 participants with available ethnicity data were of White ethnicity and 47 (30%) of 155 were living with HIV with a median CD4 count of 510 cells per mm3(IQR 349–828). Rectal or perianal pain (including proctitis) was the most common indication for hospital admission (44 [28%] of 156). Severe pain was reported in 89 (57%) of 156, and secondary bacterial infection in 82 (58%) of 142 individuals with available data. Median admission duration was 5 days (IQR 2–9). Ten individuals required surgery and two cases of encephalitis were reported. 38 (24%) of the 156 individuals received tecovirimat with early cessation in four cases (two owing to hepatic transaminitis, one to rapid treatment response, and one to patient choice). No deaths occurred during the study period. Interpretation:Although life-threatening mpox appears rare in hospitalised populations during the current outbreak, severe mpox and associated complications can occur in immunocompetent individuals. Analgesia and management of superimposed bacterial infection are priorities for patients admitted to hospital.
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- 2023
3. Filling observational gaps with crowdsourced citizen science rainfall data from the Met Office Weather Observation Website
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Tess O'Hara, Fergus McClean, Roberto Villalobos Herrera, Elizabeth Lewis, and Hayley J. Fowler
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Water Science and Technology - Abstract
This paper demonstrates the potential for crowdsourced rainfall data to infill gaps in the official rain gauge network and to provide new datasets for use in research. We use data from the Met Office Weather Observation Website (WOW) over 10 years (2011–2020) to generate two open-source datasets for Britain; multi-parameter raw data in an easy-to-use format; and an hourly rainfall dataset. We have compiled and prepared the data and detail here station selection, rain depth calculation, and data resampling to hourly intervals to create a consistent dataset for further processing (including statistical quality control) and application. Mapping the new rainfall dataset establishes that WOW observations fill spatial gaps in the official ground-based rain gauge network over Britain, particularly in urban areas. This could be particularly useful for post-event analysis of rainfall that results in pluvial flash flooding. Here, we focus on Britain but due to agreements with meteorological services in Belgium, the Netherlands, Australia, New Zealand, Sweden, and the Republic of Ireland, plus many citizen scientists globally opting to share data via WOW, there is potential for the development of similar datasets using these methods around the world.
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- 2023
4. Revision Parathyroid Surgery – Challenges and Considerations in Comparison to Primary Surgery
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A McClean and RJA England
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Otorhinolaryngology ,General Medicine - Published
- 2023
5. Blood flow restriction during high-intensity interval cycling exacerbates psychophysiological responses to a greater extent in females than males
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Zachary J. McClean, Abbey Young, Andrew J. Pohl, Nowell M. Fine, Jamie F. Burr, Martin MacInnis, and Saied J. Aboodarda
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Physiology ,Physiology (medical) - Abstract
To our knowledge, no study has explored sex differences in the neuromuscular, perceptual, and cardiorespiratory indices characterizing exercise tolerance during high-intensity interval training (HIIT) with blood flow restriction (BFR) applied only during rest periods. Our results suggest that BFR elicited a decline in exercise performance that could be attributed to integration of psychophysiological responses. However, this integration was sex-dependent where females demonstrated an exacerbated rate of change in these responses compared with males.
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- 2023
6. Shared Burial Grounds
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David McClean and Penny McClean
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Religious studies ,Law - Abstract
Despite the widespread use of cremation, there is once again a shortage of burial space in some parts of the country. Chancellors dealing with petitions for faculties reserving grave spaces are finding that more and more parochial church councils are opposing reservation as they see that the available space is running out. In rural areas it may be possible to persuade a farmer or landowner to part with some land to form a new burial ground, perhaps serving a number of adjacent parishes. Section 35 of the Church Property Measure 2018 sets out the law relating to shared burial grounds, developed in a series of nineteenth-century Acts which a modern reader would find both prolix and overcomplicated. This article explores the history and practical workings of the law, illustrating these by reference to a prime example of a shared burial ground, the Mill Road Cemetery (more formally the Parochial Burial Grounds) in Cambridge.1 The law as to rights in graves and the memorials placed on them causes much misunderstanding. Our account will show that the same may be true with regard to the burial ground as a whole.
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- 2022
7. The transfer of proceedings in international family cases
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David McClean
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Political Science and International Relations ,Law - Published
- 2023
8. Shorter High-Intensity Cycling Intervals Reduce Performance and Perceived Fatigability at Work-Matched but Not Task Failure
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ZACHARY MCCLEAN, DANILO IANNETTA, MARTIN MACINNIS, and SAIED JALAL ABOODARDA
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Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine - Published
- 2022
9. Strain‐dependent differences in coordination of yeast signalling networks
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Taylor D. Scott, Ping Xu, and Megan N. McClean
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Cell Biology ,Molecular Biology ,Biochemistry - Abstract
The yeast mitogen-activated protein kinase pathways serve as a model system for understanding how network interactions affect the way in which cells coordinate the response to multiple signals. We have quantitatively compared two yeast strain backgrounds YPH499 and Σ1278b (both of which have previously been used to study these pathways) and found several important differences in how they coordinate the interaction between the high osmolarity glycerol (HOG) and mating pathways. In the Σ1278b background, in response to simultaneous stimulus, mating pathway activation is dampened and delayed in a dose-dependent manner. In the YPH499 background, only dampening is dose-dependent. Furthermore, leakage from the HOG pathway into the mating pathway (crosstalk) occurs during osmostress alone in the Σ1278b background only. The mitogen-activated protein kinase Hog1p suppresses crosstalk late in an induction time course in both strains but does not affect the early crosstalk seen in the Σ1278b background. Finally, the kinase Rck2p plays a greater role suppressing late crosstalk in the Σ1278b background than in the YPH499 background. Our results demonstrate that comparisons between laboratory yeast strains provide an important resource for understanding how signalling network interactions are tuned by genetic variation without significant alteration to network structure.
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- 2022
10. Seasonal and Year-To-Year Variability of Boundary Currents and Eddy Salt Flux along the Eastern and Southern Coasts of Sri Lanka Observed by PIES and Satellite Measurements
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A. Anutaliya, U. Send, J. L. McClean, J. Sprintall, M. Lankhorst, C. M. Lee, L. Rainville, W. N. C. Priyadarshani, and S. U. P. Jinadasa
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Oceanography - Abstract
Boundary currents along the Sri Lankan eastern and southern coasts serve as a pathway for salt exchange between the Bay of Bengal and the Arabian Sea basins in the northern Indian Ocean, which are characterized by their contrasting salinities. Measurements from two pairs of pressure-sensing inverted echo sounders (PIES) deployed along the Sri Lankan eastern and southern coasts as well as satellite measurements are used to understand the variability of these boundary currents and the associated salt transport. The volume transport in the surface (0–200-m depth) layer exhibits a seasonal cycle associated with the monsoonal wind reversal and interannual variability associated with the Indian Ocean dipole (IOD). In this layer, the boundary currents transport low-salinity water out of the Bay of Bengal during the northeast monsoon and transport high-salinity water into the Bay of Bengal during the fall monsoon transition of some years (e.g., 2015 and 2018). The Bay of Bengal salt input increases during the 2016 negative IOD as the eastward flow of high-salinity water during the fall monsoon transition intensifies, whereas the effect of the 2015/16 El Niño on the Bay of Bengal salt input is still unclear. The time-mean eddy salt flux over the upper 200 m estimated for the April 2015–March 2019 period along the eastern coast accounts for 9% of the salt budget required to balance an estimated 0.13 Sv (1 Sv ≡ 106 m3 s−1) of annual freshwater input into the Bay of Bengal. The time-mean eddy salt flux over the upper 200 m estimated for the December 2015–November 2019 period along the southern coast accounts for 27% of that same salt budget. Significance Statement In the northern Indian Ocean, the highly saline Arabian Sea undergoes extreme evaporation while the Bay of Bengal (BoB) receives excess freshwater input. The focus of this study is the role of the observed time-variable circulation around Sri Lanka that permits the exchange between these basins to maintain their salinity distributions. The circulation fluctuates seasonally following the monsoon wind reversal and interannually in response to large-scale climate modes. The BoB freshwater export around Sri Lanka occurs during the northeast monsoon, whereas saline water import occurs during the fall monsoon transition of some years. However, rapid changes in both water volume transport and salt exchange can occur. The circulation over 0–200-m depth transports ∼9%–27% of the BoB salt budget.
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- 2022
11. Genetic Resources and Breeding Priorities in Phaseolus Beans
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Travis A. Parker, Jorge Acosta Gallegos, James Beaver, Mark Brick, Judith K. Brown, Karen Cichy, Daniel G. Debouck, Alfonso Delgado‐Salinas, Sarah Dohle, Emmalea Ernest, Consuelo Estevez de Jensen, Francisco Gomez, Barbara Hellier, Alexander V. Karasev, James D. Kelly, Phillip McClean, Phillip Miklas, James R. Myers, Juan M. Osorno, Julie S. Pasche, Marcial A. Pastor‐Corrales, Timothy Porch, James R. Steadman, Carlos Urrea, Lyle Wallace, Christine H. Diepenbrock, and Paul Gepts
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- 2022
12. Japan's Aging Antimilitarism Is Alive and Well
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Charles T. McClean
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History ,Political Science and International Relations - Published
- 2023
13. Towards automatic placement of media objects in a personalised TV experience
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Brahim Allan, Ian Kegel, Sri Harish Kalidass, Andriy Kharechko, Michael Milliken, Sally McClean, Bryan Scotney, and Shuai Zhang
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Computer Networks and Communications ,Hardware and Architecture ,Media Technology ,Software ,Information Systems - Published
- 2022
14. The impact of hegemonic masculine ideals on self‐esteem in prostate cancer patients undergoing androgen deprivation therapy (ADT) compared to ADT‐naïve patients
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Caterina, Gentili, Stuart, McClean, Lucy, McGeagh, Amit, Bahl, Raj, Persad, and Diana, Harcourt
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Male ,Masculinity ,Psychiatry and Mental health ,Oncology ,Androgens ,Humans ,Prostatic Neoplasms ,Androgen Antagonists ,Experimental and Cognitive Psychology ,Middle Aged ,Self Concept ,Aged - Abstract
Androgen deprivation therapy (ADT) for Prostate Cancer (PCa) is associated with side effects that could lead to negative body image and low masculine self-esteem of survivors. We compared a group of PCa survivors following ADT with ADT-naïve patients, expecting the ADT group to show lower masculine self-esteem. We also expected patients with hegemonic masculinity ideals to show poorer masculine self-esteem and we hypothesized that ADT would moderate this relationship, expecting PCa patients on ADT with stronger hegemonic ideals to show the worst masculine self-esteem scores among study participants.We compared 57 PCa survivors on ADT (Msubage/sub = 64.16 (7.11)) to 59 ADT-naïve patients (Msubage/sub = 65.25 (5.50)), on the Masculine Self-Esteem Scale (MSES), Body Image Scale (BIS), and Hegemonic Masculinity Ideals Scale (HMIS).While the two groups did not significantly differ on masculine self-esteem (F [1, 115] = 3.46, p = 0.065, ηsubp/subsup2/sup = 0.029) and body image (F [1, 115] = 3.46, p = 0.065, ηsubp/subsup2/sup = 0.029), younger age was significantly associated with higher body image issues (F [1, 115] = 8.63, p lt; 0.01, ηsubp/subsup2/sup = 0.071, β = -0.30). Hegemonic masculinity significantly predicted more masculine self-esteem related issues (t (2, 114) = 2.31, β = 0.375, p lt; 0.05). ADT did not moderate this relationship.The results suggest that endorsing hegemonic masculinity could represent a risk factor for low masculine self-esteem regardless of ADT status and that younger age is associated with negative body image among PCa survivors.These results suggest the importance of inclusion of topics related to hegemonic masculinity when providing support to PCa survivors, both when discussing treatment side effects, as well as in the later phases of survivorship. This pilot also suggests that younger PCa survivors might benefit from body-image focused support regardless of treatment plan.
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- 2022
15. Predictors of VA Primary Care Clerical Staff Burnout Using the Job Demands-Resources Model
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Medich, Melissa, Rose, Danielle, McClean, Michael, Nelson, Karin, Stewart, Gregory, Ganz, David A, Yano, Elizabeth M, and Stockdale, Susan E
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burnout ,Primary Health Care ,Health Policy ,medical support assistants ,Job Satisfaction ,clerks ,primary care ,Good Health and Well Being ,Job Demands-Resources model ,Surveys and Questionnaires ,Professional ,Primary Care Clerical Staff Reorganization ,Health Policy & Services ,Humans ,Burnout, Professional - Abstract
Primary care clerical staff may experience burnout if not adequately prepared and supported for patient-facing customer service tasks. Guided by the Job Demands-Resources (JD-R) model, we use national survey data from 707 primary care clerks at 349 VA clinics (2018; response rate: 12%) to evaluate associations between clerks' perceptions of tasks, work environment, training, and burnout. We found challenges with customer-facing tasks contribute to higher burnout, and supportive work environment was associated with lower burnout. Although perceptions of training were not associated with burnout, our results combined with the JD-R model suggest that customer service training may protect against burnout.
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- 2022
16. Innovation in gastrointestinal surgery: the evolution of minimally invasive surgery—a narrative review
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Josephine Walshaw, Bright Huo, Adam McClean, Samantha Gajos, Jing Yi Kwan, James Tomlinson, Chandra Shekhar Biyani, Safaa Dimashki, Ian Chetter, and Marina Yiasemidou
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Surgery - Abstract
BackgroundMinimally invasive (MI) surgery has revolutionised surgery, becoming the standard of care in many countries around the globe. Observed benefits over traditional open surgery include reduced pain, shorter hospital stay, and decreased recovery time. Gastrointestinal surgery in particular was an early adaptor to both laparoscopic and robotic surgery. Within this review, we provide a comprehensive overview of the evolution of minimally invasive gastrointestinal surgery and a critical outlook on the evidence surrounding its effectiveness and safety.MethodsA literature review was conducted to identify relevant articles for the topic of this review. The literature search was performed using Medical Subject Heading terms on PubMed. The methodology for evidence synthesis was in line with the four steps for narrative reviews outlined in current literature. The key words used were minimally invasive, robotic, laparoscopic colorectal, colon, rectal surgery.ConclusionThe introduction of minimally surgery has revolutionised patient care. Despite the evidence supporting this technique in gastrointestinal surgery, several controversies remain. Here we discuss some of them; the lack of high level evidence regarding the oncological outcomes of TaTME and lack of supporting evidence for robotic colorectalrectal surgery and upper GI surgery. These controversies open pathways for future research opportunities with RCTs focusing on comparing robotic to laparoscopic with different primary outcomes including ergonomics and surgeon comfort.
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- 2023
17. Adoption des médicaments biosimilaires au Canada : analyse des politiques provinciales et données sur leur utilisation
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Alison R. McClean, Michael R. Law, Mark Harrison, Nick Bansback, Tara Gomes, and Mina Tadrous
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General Medicine - Published
- 2022
18. A Study of Maternal and Umbilical Cord Blood Lead Levels in Pregnant Women
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Abbas Ali Mahdi, Jamal Akhtar Ansari, Priyanka Chaurasia, Mohammad Kaleem Ahmad, Shipra Kunwar, Sally McClean, and Pratheepan Yogarajah
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Clinical Biochemistry - Published
- 2022
19. Impaired Ventilatory Efficiency, Dyspnea, and Exercise Intolerance in Chronic Obstructive Pulmonary Disease: Results from the CanCOLD Study
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Devin B. Phillips, Amany F. Elbehairy, Matthew D. James, Sandra G. Vincent, Kathryn M. Milne, Juan P. de-Torres, J. Alberto Neder, Miranda Kirby, Dennis Jensen, Michael K. Stickland, Jordan A. Guenette, Benjamin M. Smith, Shawn D. Aaron, Wan C. Tan, Jean Bourbeau, Denis E. O’Donnell, Jonathon Samet, Milo Puhan, James C. Hogg, Qutayba Hamid, Dany Doiron, Palmina Mancino, Pei-Zhi Li, Zhi Song, Yvan Fortier, Kenneth Chapman, Patricia McClean, Jane Duke, Andrea S. Gershon, Teresa Toh, Mohsen Sadatsafavi, Don Sin, J. Mark Fitzgerald, Jeremy Road, Christine Lo, Sarah Cheng, Elena Un, Michael Cheng, Cynthia Fung, Faize Faroon, Olga Radivojevic, Sally Chung, Carl Zou, Rena Choi, Joe Comeau, Harvey Coxson, Jonathon Leipsic, Cameron Hague, Brandie Walker, Curtis Dumonceaux, Paul Hernandez, Scott Fulton, Kathy Vandemheen, Matthew McNeil, Kate Whelan, Francois Maltais, Cynthia Brouillard, Darcy Marciniuk, Ron Clemens, and Janet Baran
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Pulmonary and Respiratory Medicine ,Pulmonary Disease, Chronic Obstructive ,Dyspnea ,Exercise Tolerance ,Pulmonary Gas Exchange ,Exercise Test ,Humans ,Carbon Dioxide ,Critical Care and Intensive Care Medicine - Published
- 2022
20. Quantum advantage in learning from experiments
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Hsin-Yuan Huang, Michael Broughton, Jordan Cotler, Sitan Chen, Jerry Li, Masoud Mohseni, Hartmut Neven, Ryan Babbush, Richard Kueng, John Preskill, and Jarrod R. McClean
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FOS: Computer and information sciences ,Quantum Physics ,Computer Science - Machine Learning ,Multidisciplinary ,Computer Science - Information Theory ,Information Theory (cs.IT) ,FOS: Physical sciences ,Quantum Physics (quant-ph) ,Machine Learning (cs.LG) - Abstract
Quantum technology has the potential to revolutionize how we acquire and process experimental data to learn about the physical world. An experimental setup that transduces data from a physical system to a stable quantum memory, and processes that data using a quantum computer, could have significant advantages over conventional experiments in which the physical system is measured and the outcomes are processed using a classical computer. We prove that, in various tasks, quantum machines can learn from exponentially fewer experiments than those required in conventional experiments. The exponential advantage holds in predicting properties of physical systems, performing quantum principal component analysis on noisy states, and learning approximate models of physical dynamics. In some tasks, the quantum processing needed to achieve the exponential advantage can be modest; for example, one can simultaneously learn about many noncommuting observables by processing only two copies of the system. Conducting experiments with up to 40 superconducting qubits and 1300 quantum gates, we demonstrate that a substantial quantum advantage can be realized using today's relatively noisy quantum processors. Our results highlight how quantum technology can enable powerful new strategies to learn about nature., Comment: 6 pages, 17 figures + 46 page appendix; open-source code available at https://github.com/quantumlib/ReCirq/tree/master/recirq/qml_lfe
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- 2022
21. The positive and negative effects of social status on ratings of voice behavior: A test of opposing structural and psychological pathways
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Sarah P. Doyle, Elizabeth J. McClean, Sijun Kim, Eric Lin, Todd Woodruff, and Nathan P. Podsakoff
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Admiration ,Field (Bourdieu) ,PsycINFO ,Social Status ,Moderation ,Social Networking ,Risk perception ,Interpersonal relationship ,Humans ,Interpersonal Relations ,Centrality ,Psychology ,Social psychology ,Applied Psychology ,Social status - Abstract
We examine how social status-the amount of respect and admiration conferred by others-is related to leader ratings of team member voice. In a field study using 373 West Point cadets nested in 60 squads, we find that there are two countervailing pathways linking social status to leader voice ratings: A positive structural path via instrumental network centrality and a negative psychological path via perceived image risk. In addition, we show that these relationships are contingent upon a relational moderator, such that high-quality team interpersonal relationships weakened the positive indirect effect via instrumental network centrality but strengthened the negative indirect effect via image risk. Two post hoc experiments provided preliminary support for our arguments that perceived image risk causes people to deliver their voice in a manner that is more acceptable to recipients and ruled out several alternative explanations. The results of our multilevel analyses shed new light on how, why, and when social status impacts leader ratings of voice. In doing so, we challenge assumptions in the extant voice research and open avenues for future research. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
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- 2022
22. When Conscientious Employees Meet Intelligent Machines: An Integrative Approach Inspired by Complementarity Theory and Role Theory
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Joel Koopman, Chin Tung Stewart Ng, Shawn T. McClean, Chi Hon Li, Jack H. Zhang, Yizhen Lu, David De Cremer, and Pok Man Tang
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Ability to work ,Strategy and Management ,Conscientiousness ,Role theory ,General Business, Management and Accounting ,Organizational behavior ,Complementarity theory ,Management of Technology and Innovation ,Trait ,Business and International Management ,Predicting performance ,Topic areas ,Psychology ,Cognitive psychology - Abstract
Over the past century, conscientiousness has become seen as the preeminent trait for predicting performance. This consensus is due in part to these employees’ ability to work with traditional, 20th...
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- 2022
23. Health promotion in emergency care settings: investigating staff views and experiences
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Behnaz Schofield, Rebecca Hoskins, Ursula Rolfe, Stuart McClean, Sarah Voss, and Jonathan Benger
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Emergency Nursing - Published
- 2023
24. The effect of body mass index at cancer diagnosis on survival of patients with squamous cell head and neck carcinoma
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Roberta Pastorino, Denise Pires Marafon, Ilda Hoxhaj, Adriano Grossi, Luca Giraldi, Antonella Rondinò, Gabriella Cadoni, Jerry Polesel, Diego Serraino, Carlo La Vecchia, Werner Garavello, Cristina Canova, Lorenzo Richiardi, Jolanta Lissowska, Tamas Pandics, Tom Dudding, Andy Ness, Steve Thomas, Miranda Pring, Karl Kelsey, Michael McClean, Patrick T. Bradshaw, Zuo-Feng Zhang, Hal Morgenstern, Laura Rozek, Gregory T. Wolf, Andrew F. Olshan, Geoffrey Liu, Rayjean J. Hung, Marta Vilensky, Marcos Brasilino de Carvalho, Rossana Veronica Mendonza Lopez, Victor Wunsch-Filho, Paolo Boffetta, Mia Hashibe, Yuan-Chin Amy Lee, and Stefania Boccia
- Abstract
The aim of this study is to investigate the prognostic role of body mass index (BMI) and survival from head and neck cancer (HNC). We performed a pooled analysis of studies included in the International Head and Neck Cancer Epidemiology consortium in order to investigate the prognostic role of BMI and survival from HNC. We used Cox proportional hazards models to estimate the adjusted hazard ratios (HR) for overall survival and HNC-specific survival, by cancer site. The study included 10,177 patients from 10 studies worldwide. Underweight patients had lower overall survival (HR = 1.69, 95%CI: 1.31–2.19) respect to those having normal weight with consistent results across the HNC sites. Overweight and obese patients with oropharyngeal cancers had a favourable HNC-specific survival (HR = 0.50 (95%CI: 0.33–0.75) and HR = 0.51 (95%CI: 0.36–0.72), respectively). Among ever smokers overweight and obese patients showed a favourable HNC-specific survival (HR = 0.69 (95%CI: 0.56–0.86) and HR = 0.70 (95%CI: 0.61–0.80)). Our findings show that high BMI values at cancer diagnosis predict the survival rates in smoking patients with HNC. This association may be explained by residual confounding, reverse causation, and collider stratification bias, but may also suggest that a nutritional reserve may help patients survive HNC cancer.
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- 2023
25. Heat stress and heat strain among outdoor workers in El Salvador and Nicaragua
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Zoe E. Petropoulos, Sinead A. Keogh, Emmanuel Jarquín, Damaris López-Pilarte, Juan José Amador Velázquez, Ramón García-Trabanino, Magaly Rosario Amador Sánchez, Raúl Guevara, Alexa Gruener, Dustin R. Allen, Jessica H. Leibler, Iris S. Delgado, Michael D. McClean, David J. Friedman, Daniel R. Brooks, and Madeleine K. Scammell
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Epidemiology ,Public Health, Environmental and Occupational Health ,Toxicology ,Pollution - Abstract
Background There is growing attention on occupational heat stress in Central America, as workers in this region are affected by a unique form of chronic kidney disease. Previous studies have examined wet bulb globe temperatures and estimated metabolic rates to assess heat stress, but there are limited data characterizing heat strain among these workers. Objective The aims were to characterize heat stress and heat strain and examine whether job task, break duration, hydration practices, and kidney function were associated with heat strain. Methods We used data from the MesoAmerican Nephropathy Occupational Study, a cohort of 569 outdoor workers in El Salvador and Nicaragua who underwent workplace exposure monitoring, including continuous measurement of core body temperature (Tc), heart rate (HR), physical activity, and wet bulb globe temperature (WBGT), over the course of three days in January 2018 - May 2018. Participants represented five industries: sugarcane, corn, plantain, brickmaking, and construction. Results Median WBGTs were relatively high (>27 °C) at most sites, particularly when work shifts spanned the afternoon hours (e.g., 29.2 °C among plantain workers). Sugarcane workers, especially cane cutters in both countries and Nicaraguan agrichemical applicators, had the highest estimated metabolic rates (medians: 299–318 kcal/hr). Most workers spent little time on break (c and HR values. However, a few workers in other industries reached high Tc (>39 °C) as well. Impaired kidney function (estimated glomerular filtration rate 2) was associated with higher Tc and HR values, even after adjustment. Significance This is the largest study to-date examining heat stress and strain among outdoor workers in Central America. Workers at sugar companies regularly experienced Tc > 38°C (76.9% of monitored person-days at Nicaraguan companies; 46.5% at Salvadoran companies). Workers with impaired kidney function had higher measures of Tc and HR. Impact statement This study examined levels of occupational heat stress and heat strain experienced among outdoor workers in five industries in El Salvador and Nicaragua. We characterized heat stress using wet bulb globe temperatures and estimated metabolic rate and heat strain using core body temperature and heart rate. Sugarcane workers, particularly cane cutters and Nicaraguan agrichemical applicators, performed more strenuous work and experienced greater levels of heat strain. Impaired kidney function was associated with higher heart rates and core body temperatures.
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- 2023
26. Quantum information phases in space-time: measurement-induced entanglement and teleportation on a noisy quantum processor
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Jesse Hoke, Matteo Ippoliti, Dmitry Abanin, Rajeev Acharya, Markus Ansmann, Frank Arute, Kunal Arya, Abraham Asfaw, Juan Atalaya, Ryan Babbush, Joseph Bardin, Andreas Bengtsson, Gina Bortoli, Alexandre Bourassa, Jenna Bovaird, Leon Brill, Michael Broughton, Bob Buckley, David Buell, Tim Burger, Brian Burkett, Nicholas Bushnell, Zijun Chen, Ben Chiaro, Desmond Chik, Charina Chou, Josh Cogan, Roberto Collins, Paul Conner, William Courtney, Alexander Crook, Ben Curtin, Alejandro Grajales Dau, Dripto Debroy, Alexander Del Toro Barba, Sean Demura, Augustin Di Paolo, Ilya Drozdov, Andrew Dunsworth, Daniel Eppens, Catherine Erickson, Lara Faoro, Edward Farhi, Reza Fatemi, Vinicius Ferreira, Leslie Flores Burgos, Ebrahim Forati, Austin Fowler, Brooks Foxen, William Giang, Craig Gidney, Dar Gilboa, Marissa Giustina, Raja Gosula, Jonathan Gross, Steve Habegger, Michael Hamilton, Monica Hansen, Matthew Harrigan, Sean Harrington, Paula Heu, Markus Hoffmann, Sabrina Hong, Trent Huang, Ashley Huff, William Huggins, Sergei Isakov, Justin Iveland, E. Jeffrey, Cody Jones, Pavol Juhas, Dvir Kafri, Kostyantyn Kechedzhi, Tanuj Khattar, Mostafa Khezri, Marika Kieferova, Seon Kim, Alexei Kitaev, Paul Klimov, Andrey Klots, Alexander Korotkov, Fedor Kostritsa, John Mark Kreikebaum, David Landhuis, Pavel Laptev, Kim-Ming Lau, Lily Laws, Joonho Lee, Kenny Lee, Yuri Lensky, Brian Lester, Alexander Lill, Wayne Liu, Aditya Locharla, Fionn Malone, Orion Martin, Jarrod McClean, Matt McEwen, Kevin Miao, Amanda Mieszala, Shirin Montazeri, Alexis Morvan, Ramis Movassagh, Wojciech Mruczkiewicz, Matthew Neeley, Charles Neill, Ani Nersisyan, Michael Newman, Jiun How Ng, Anthony Nguyen, Murray Nguyen, Murphy Niu, Thomas O'Brien, Seun Omonije, Alex Opremcak, Andre Petukhov, Rebecca Potter, Leonid Pryadko, Chris Quintana, Charles Rocque, Nicholas Rubin, Negar Saei, Daniel Sank, Kannan Sankaragomathi, Kevin Satzinger, Henry Schurkus, Christopher Schuster, Michael Shearn, Aaron Shorter, Noah Shutty, Shvarts Vladimir, Jindra Skruzny, W. Smith, Rolando Somma, George Sterling, Doug Strain, Marco Szalay, Alfredo Torres, Guifre Vidal, Benjamin Villalonga, Catherine Vollgraff Heidweiller, Theodore White, Bryan Woo, Cheng Xing, Z. Jamie Yao, Ping Yeh, Juhwan Yoo, Grayson Young, Adam Zalcman, Yaxing Zhang, Ningfeng Zhu, Nicholas Zobrist, Hartmut Neven, Dave Bacon, Sergio Boixo, Jeremy Hilton, Erik Lucero, Anthony Megrant, Julian Kelly, Yu Chen, Vadim Smelyanskiy, Xiao Mi, Vedika Khemani, and Pedram Roushan
- Abstract
Measurement has a special role in quantum theory1: by collapsing the wavefunction it can enable phenomena such as teleportation2 and thereby alter the "arrow of time" that constrains unitary evolution. When integrated in many-body dynamics, measurements can lead to emergent patterns of quantum information in space-time3-10 that go beyond established paradigms for characterizing phases, either in or out of equilibrium11-13. On present-day NISQ processors14, the experimental realization of this physics is challenging due to noise, hardware limitations, and the stochastic nature of quantum measurement. Here we address each of these experimental challenges and investigate measurement-induced quantum information phases on up to 70 superconducting qubits. By leveraging the interchangeability of space and time, we use a duality mapping9,15-17 to avoid mid-circuit measurement and access different manifestations of the underlying phases—from entanglement scaling3,4 to measurement-induced teleportation18—in a unified way. We obtain finite-size signatures of a phase transition with a decoding protocol that correlates the experimental measurement record with classical simulation data. The phases display sharply different sensitivity to noise, which we exploit to turn an inherent hardware limitation into a useful diagnostic. Our work demonstrates an approach to realize measurement-induced physics at scales that are at the limits of current NISQ processors.
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- 2023
27. Trends in Use of Combination Antiretroviral Therapy and Treatment Response from 2000 to 2016 in the Canadian Observational Cohort (CANOC): A Longitudinal Cohort Study
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Alison R McClean, Jason Trigg, Claudette Cardinal, Mona Loutfy, Curtis Cooper, Abigail Kroch, Mostafa Shokoohi, Nimâ Machouf, Réjean Thomas, Marina B Klein, Deborah V Kelly, Alexander Wong, Stephen Sanche, Julio S G Montaner, and Robert S Hogg, on behalf of the CANOC Collaboration
- Subjects
Pharmacology (medical) ,Pharmacy ,Original Research - Abstract
Background: Advances in treatment have turned HIV from a terminal illness to a more manageable condition. Over the past 20 years, there have been considerable changes to HIV treatment guidelines, including changes in preferred antiretrovirals and timing of initiation of combination antiretroviral therapy (cART). Objective: To examine real-world trends in cART utilization, viral control, and immune reconstitution among people living with HIV in Canada. Methods: Data were obtained from the Canadian Observational Cohort (CANOC). CANOC participants were eligible if they were antiretroviral therapy–naive at entry and initiated 3 or more antiretrovirals on or after January 1, 2000; if they were at least 18 years of age at treatment initiation; if they were residing in Canada; and if they had at least 1 viral load determination and CD4 count within 1 year of CANOC entry. Baseline and annual mean CD4 counts were categorized as less than 200, 200–350, 351–500, and more than 500 cells/mm3. Annual mean viral loads were reported as suppressed (
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- 2023
28. Supplementary Tables 1-3 from A Sex-Specific Association between a 15q25 Variant and Upper Aerodigestive Tract Cancers
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James D. McKay, Paul Brennan, Paolo Boffetta, Richard B. Hayes, Mia Hashibe, Stefania Boccia, Leticia Fernandez, José Eluf-Neto, Victor Wünsch-Filho, Ana Menezes, Sergio Koifman, Maria Paula Curado, Vladimir Janout, Lenka Foretova, Vladimir Bencko, Alexandru Bucur, Eleonora Fabianova, Jolanta Lissowska, Neonila Szeszenia-Dabrowska, David Zaridze, Wolfgang Ahrens, Claire M. Healy, Ariana Znaor, David I. Conway, Nalin S. Thakker, Cristina Canova, Luigi Barzan, Tatiana V. Macfarlane, Xavier Castellsagué, Antonio Agudo, Kristina Kjaerheim, Lorenzo Richiardi, Ivana Holcátová, Pagona Lagiou, Simone Benhamou, Chu Chen, Stephen M. Schwartz, Renyi Wang, Shen-Chih Chang, Zuo-Feng Zhang, Erich M. Sturgis, Qingyi Wei, Philip Lazarus, Joshua E. Muscat, Marcin Lener, Joanna Trubicka, Jan Lubiński, Wilbert H. M. Peters, Johannes J. Manni, Martin Lacko, Michael D. McClean, Brock Christensen, Karl T. Kelsey, Renato Talamini, Rolando Herrero, Silvia Franceschi, Tomoko Nukui, Shama Buch, Marjorie Romkes, Jingchun Luo, Mark C. Weissler, Andrew F. Olshan, Shu-chun Chuang, Amelie Chabrier, Graham Byrnes, Valerie Gaborieau, Therese Truong, and Dan Chen
- Abstract
Supplementary Tables 1-3 from A Sex-Specific Association between a 15q25 Variant and Upper Aerodigestive Tract Cancers
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- 2023
29. Supplementary Table S5 from Association of Marijuana Smoking with Oropharyngeal and Oral Tongue Cancers: Pooled Analysis from the INHANCE Consortium
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Gypsyamber D'Souza, Mia Hashibe, Yuan-Chin Amy Lee, Paolo Boffetta, Marshall Posner, Leticia Fernandez, Alexander W. Daudt, Ana Menezes, Elena Matos, Sergio Koifman, Maria Paula Curado, Victor Wunsch-Filho, Thomas L. Vaughan, Chu Chen, Michael McClean, Philip Lazarus, Joshua Muscat, Hal Morgenstern, Zuo-Feng Zhang, Erich M. Sturgis, Qingyi Wei, Andrew F. Olshan, Paul Brennan, Annah Wyss, Elaine Smith, Stephen M. Schwartz, Julien Berthiller, Kurt Straif, Karl Kelsey, Anil K. Chaturvedi, and Morgan A. Marks
- Abstract
Association of frequency of marijuana use, duration of marijuana, and joint years of marijuana use with oropharyngeal and oral tongue cancers
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- 2023
30. Supplementary Table S1 from Global Hypomethylation Identifies Loci Targeted for Hypermethylation in Head and Neck Cancer
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Karl T. Kelsey, Carmen J. Marsit, Michael Pawlita, Tim Waterboer, Michael D. McClean, Michele Avissar-Whiting, Rondi A. Butler, Brock C. Christensen, E. Andres Houseman, and Graham M. Poage
- Abstract
Supplementary Table S1 from Global Hypomethylation Identifies Loci Targeted for Hypermethylation in Head and Neck Cancer
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- 2023
31. Supplementary Table S1 from Association of Marijuana Smoking with Oropharyngeal and Oral Tongue Cancers: Pooled Analysis from the INHANCE Consortium
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Gypsyamber D'Souza, Mia Hashibe, Yuan-Chin Amy Lee, Paolo Boffetta, Marshall Posner, Leticia Fernandez, Alexander W. Daudt, Ana Menezes, Elena Matos, Sergio Koifman, Maria Paula Curado, Victor Wunsch-Filho, Thomas L. Vaughan, Chu Chen, Michael McClean, Philip Lazarus, Joshua Muscat, Hal Morgenstern, Zuo-Feng Zhang, Erich M. Sturgis, Qingyi Wei, Andrew F. Olshan, Paul Brennan, Annah Wyss, Elaine Smith, Stephen M. Schwartz, Julien Berthiller, Kurt Straif, Karl Kelsey, Anil K. Chaturvedi, and Morgan A. Marks
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Description of the studies utilized in assessment of the association of marijuana use and head and neck cancer in INHANCE
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- 2023
32. Supplementary Table S2 from Association of Marijuana Smoking with Oropharyngeal and Oral Tongue Cancers: Pooled Analysis from the INHANCE Consortium
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Gypsyamber D'Souza, Mia Hashibe, Yuan-Chin Amy Lee, Paolo Boffetta, Marshall Posner, Leticia Fernandez, Alexander W. Daudt, Ana Menezes, Elena Matos, Sergio Koifman, Maria Paula Curado, Victor Wunsch-Filho, Thomas L. Vaughan, Chu Chen, Michael McClean, Philip Lazarus, Joshua Muscat, Hal Morgenstern, Zuo-Feng Zhang, Erich M. Sturgis, Qingyi Wei, Andrew F. Olshan, Paul Brennan, Annah Wyss, Elaine Smith, Stephen M. Schwartz, Julien Berthiller, Kurt Straif, Karl Kelsey, Anil K. Chaturvedi, and Morgan A. Marks
- Abstract
Association of Ever Marijuana use and oropharyngeal cancer stratified by HPV 16 L1 serostatus.
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- 2023
33. Supplementary Table S3 from Association of Marijuana Smoking with Oropharyngeal and Oral Tongue Cancers: Pooled Analysis from the INHANCE Consortium
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Gypsyamber D'Souza, Mia Hashibe, Yuan-Chin Amy Lee, Paolo Boffetta, Marshall Posner, Leticia Fernandez, Alexander W. Daudt, Ana Menezes, Elena Matos, Sergio Koifman, Maria Paula Curado, Victor Wunsch-Filho, Thomas L. Vaughan, Chu Chen, Michael McClean, Philip Lazarus, Joshua Muscat, Hal Morgenstern, Zuo-Feng Zhang, Erich M. Sturgis, Qingyi Wei, Andrew F. Olshan, Paul Brennan, Annah Wyss, Elaine Smith, Stephen M. Schwartz, Julien Berthiller, Kurt Straif, Karl Kelsey, Anil K. Chaturvedi, and Morgan A. Marks
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Association of marijuana use and oral tongue†cancer stratified smoking/drinking intensity
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- 2023
34. Supplementary Table S5 from Global Hypomethylation Identifies Loci Targeted for Hypermethylation in Head and Neck Cancer
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Karl T. Kelsey, Carmen J. Marsit, Michael Pawlita, Tim Waterboer, Michael D. McClean, Michele Avissar-Whiting, Rondi A. Butler, Brock C. Christensen, E. Andres Houseman, and Graham M. Poage
- Abstract
Supplementary Table S5 from Global Hypomethylation Identifies Loci Targeted for Hypermethylation in Head and Neck Cancer
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- 2023
35. Supplementary Table S4 from Association of Marijuana Smoking with Oropharyngeal and Oral Tongue Cancers: Pooled Analysis from the INHANCE Consortium
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Gypsyamber D'Souza, Mia Hashibe, Yuan-Chin Amy Lee, Paolo Boffetta, Marshall Posner, Leticia Fernandez, Alexander W. Daudt, Ana Menezes, Elena Matos, Sergio Koifman, Maria Paula Curado, Victor Wunsch-Filho, Thomas L. Vaughan, Chu Chen, Michael McClean, Philip Lazarus, Joshua Muscat, Hal Morgenstern, Zuo-Feng Zhang, Erich M. Sturgis, Qingyi Wei, Andrew F. Olshan, Paul Brennan, Annah Wyss, Elaine Smith, Stephen M. Schwartz, Julien Berthiller, Kurt Straif, Karl Kelsey, Anil K. Chaturvedi, and Morgan A. Marks
- Abstract
Age and Sex stratified analysis on the association of ever marijuana use and oral tongue cancer
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- 2023
36. Supplementary Table S4 from Global Hypomethylation Identifies Loci Targeted for Hypermethylation in Head and Neck Cancer
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Karl T. Kelsey, Carmen J. Marsit, Michael Pawlita, Tim Waterboer, Michael D. McClean, Michele Avissar-Whiting, Rondi A. Butler, Brock C. Christensen, E. Andres Houseman, and Graham M. Poage
- Abstract
Supplementary Table S4 from Global Hypomethylation Identifies Loci Targeted for Hypermethylation in Head and Neck Cancer
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- 2023
37. Data from Association of Marijuana Smoking with Oropharyngeal and Oral Tongue Cancers: Pooled Analysis from the INHANCE Consortium
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Gypsyamber D'Souza, Mia Hashibe, Yuan-Chin Amy Lee, Paolo Boffetta, Marshall Posner, Leticia Fernandez, Alexander W. Daudt, Ana Menezes, Elena Matos, Sergio Koifman, Maria Paula Curado, Victor Wunsch-Filho, Thomas L. Vaughan, Chu Chen, Michael McClean, Philip Lazarus, Joshua Muscat, Hal Morgenstern, Zuo-Feng Zhang, Erich M. Sturgis, Qingyi Wei, Andrew F. Olshan, Paul Brennan, Annah Wyss, Elaine Smith, Stephen M. Schwartz, Julien Berthiller, Kurt Straif, Karl Kelsey, Anil K. Chaturvedi, and Morgan A. Marks
- Abstract
Background: The incidence of oropharyngeal and oral tongue cancers has increased over the last 20 years which parallels increased use of marijuana among individuals born after 1950.Methods: A pooled analysis was conducted comprising individual-level data from nine case–control studies from the United States and Latin America in the INHANCE consortium. Self-reported information on marijuana smoking, demographic, and behavioral factors was obtained from 1,921 oropharyngeal cases, 356 oral tongue cases, and 7,639 controls.Results: Compared with never marijuana smokers, ever marijuana smokers had an elevated risk of oropharyngeal [adjusted OR (aOR), 1.24; 95% confidence interval (CI): 1.06–1.47] and a reduced risk of oral tongue cancer (aOR, 0.47; 95% CI, 0.29, 0.75). The risk of oropharyngeal cancer remained elevated among never tobacco and alcohol users. The risk of oral tongue cancer was reduced among never users of tobacco and alcohol. Sensitivity analysis adjusting for potential confounding by HPV exposure attenuated the association of marijuana use with oropharyngeal cancer (aOR, 0.99; 95% CI, 0.71–1.25), but had no effect on the oral tongue cancer association.Conclusions: These results suggest that the association of marijuana use with head and neck carcinoma may differ by tumor site.Impact: The associations of marijuana use with oropharyngeal and oral tongue cancer are consistent with both possible pro- and anticarcinogenic effects of cannabinoids. Additional work is needed to rule out various sources of bias, including residual confounding by HPV infection and misclassification of marijuana exposure. Cancer Epidemiol Biomarkers Prev; 23(1); 160–71. ©2013 AACR.
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- 2023
38. Statistical Appendix from Association of Marijuana Smoking with Oropharyngeal and Oral Tongue Cancers: Pooled Analysis from the INHANCE Consortium
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Gypsyamber D'Souza, Mia Hashibe, Yuan-Chin Amy Lee, Paolo Boffetta, Marshall Posner, Leticia Fernandez, Alexander W. Daudt, Ana Menezes, Elena Matos, Sergio Koifman, Maria Paula Curado, Victor Wunsch-Filho, Thomas L. Vaughan, Chu Chen, Michael McClean, Philip Lazarus, Joshua Muscat, Hal Morgenstern, Zuo-Feng Zhang, Erich M. Sturgis, Qingyi Wei, Andrew F. Olshan, Paul Brennan, Annah Wyss, Elaine Smith, Stephen M. Schwartz, Julien Berthiller, Kurt Straif, Karl Kelsey, Anil K. Chaturvedi, and Morgan A. Marks
- Abstract
Description for sensitivity analysis to adjust for potential unmeasured confounding
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- 2023
39. Data from Global Hypomethylation Identifies Loci Targeted for Hypermethylation in Head and Neck Cancer
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Karl T. Kelsey, Carmen J. Marsit, Michael Pawlita, Tim Waterboer, Michael D. McClean, Michele Avissar-Whiting, Rondi A. Butler, Brock C. Christensen, E. Andres Houseman, and Graham M. Poage
- Abstract
Purpose: The human epigenome is profoundly altered in cancers, with a characteristic loss of methylation in repetitive regions and concomitant accumulation of gene promoter methylation. The degree to which these processes are coordinated is unclear so we investigated both in head and neck squamous cell carcinomas.Experimental Design: Global methylation was measured using the luminometric methylation assay (LUMA) and pyrosequencing of LINE-1Hs and AluYb8 repetitive elements in a series of 138 tumors. We also measured methylation of more than 27,000 CpG loci with the Illumina HumanMethylation27 Microarray (n = 91).Results:LINE-1 methylation was significantly associated with LUMA and Infinium loci methylation (Spearman's ρ = 0.52/ρ = 0.56, both P < 0.001) but not that of AluYb8. Methylation of LINE-1, AluYb8, and Infinium loci differed by tumor site (each Kruskal–Wallis, P < 0.05). Also, LINE-1 and LUMA methylation were associated with HPV16 E6 serology (each Mann–Whitney, P < 0.05). Comparing LINE-1 methylation to gene-associated methylation, we identified a distinct subset of CpG loci with significant hypermethylation associated with LINE-1 hypomethylation. An investigation of sequence features for these CpG loci revealed that they were significantly less likely to reside in repetitive elements (Gene Set Enrichment Analysis, P < 0.02), enriched in CpG islands (P < 0.001) and were proximal to transcription factor–binding sites (P < 0.05). We validated the top CpG loci that had significant hypermethylation associated with LINE-1 hypomethylation (at EVI2A, IFRD1, KLHL6, and PTPRCAP) by pyrosequencing independent tumors.Conclusions: These data indicate that global hypomethylation and gene-specific methylation processes are associated in a sequence-dependent manner, and that clinical characteristics and exposures leading to HNSCC may be influencing these processes. Clin Cancer Res; 17(11); 3579–89. ©2011 AACR.
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- 2023
40. Supplementary Table S6 from Association of Marijuana Smoking with Oropharyngeal and Oral Tongue Cancers: Pooled Analysis from the INHANCE Consortium
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Gypsyamber D'Souza, Mia Hashibe, Yuan-Chin Amy Lee, Paolo Boffetta, Marshall Posner, Leticia Fernandez, Alexander W. Daudt, Ana Menezes, Elena Matos, Sergio Koifman, Maria Paula Curado, Victor Wunsch-Filho, Thomas L. Vaughan, Chu Chen, Michael McClean, Philip Lazarus, Joshua Muscat, Hal Morgenstern, Zuo-Feng Zhang, Erich M. Sturgis, Qingyi Wei, Andrew F. Olshan, Paul Brennan, Annah Wyss, Elaine Smith, Stephen M. Schwartz, Julien Berthiller, Kurt Straif, Karl Kelsey, Anil K. Chaturvedi, and Morgan A. Marks
- Abstract
Sensitivity analysis of the effect of misclassification of marijuana use exposure on the univariate association of ever marijuana use with oropharyngeal cancer
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- 2023
41. Supplementary Table S2 from Global Hypomethylation Identifies Loci Targeted for Hypermethylation in Head and Neck Cancer
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Karl T. Kelsey, Carmen J. Marsit, Michael Pawlita, Tim Waterboer, Michael D. McClean, Michele Avissar-Whiting, Rondi A. Butler, Brock C. Christensen, E. Andres Houseman, and Graham M. Poage
- Abstract
Supplementary Table S2 from Global Hypomethylation Identifies Loci Targeted for Hypermethylation in Head and Neck Cancer
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- 2023
42. Supplementary Figures S1-S4 from Global Hypomethylation Identifies Loci Targeted for Hypermethylation in Head and Neck Cancer
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Karl T. Kelsey, Carmen J. Marsit, Michael Pawlita, Tim Waterboer, Michael D. McClean, Michele Avissar-Whiting, Rondi A. Butler, Brock C. Christensen, E. Andres Houseman, and Graham M. Poage
- Abstract
Supplementary Figures S1-S4 from Global Hypomethylation Identifies Loci Targeted for Hypermethylation in Head and Neck Cancer
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- 2023
43. Data from A Sex-Specific Association between a 15q25 Variant and Upper Aerodigestive Tract Cancers
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James D. McKay, Paul Brennan, Paolo Boffetta, Richard B. Hayes, Mia Hashibe, Stefania Boccia, Leticia Fernandez, José Eluf-Neto, Victor Wünsch-Filho, Ana Menezes, Sergio Koifman, Maria Paula Curado, Vladimir Janout, Lenka Foretova, Vladimir Bencko, Alexandru Bucur, Eleonora Fabianova, Jolanta Lissowska, Neonila Szeszenia-Dabrowska, David Zaridze, Wolfgang Ahrens, Claire M. Healy, Ariana Znaor, David I. Conway, Nalin S. Thakker, Cristina Canova, Luigi Barzan, Tatiana V. Macfarlane, Xavier Castellsagué, Antonio Agudo, Kristina Kjaerheim, Lorenzo Richiardi, Ivana Holcátová, Pagona Lagiou, Simone Benhamou, Chu Chen, Stephen M. Schwartz, Renyi Wang, Shen-Chih Chang, Zuo-Feng Zhang, Erich M. Sturgis, Qingyi Wei, Philip Lazarus, Joshua E. Muscat, Marcin Lener, Joanna Trubicka, Jan Lubiński, Wilbert H. M. Peters, Johannes J. Manni, Martin Lacko, Michael D. McClean, Brock Christensen, Karl T. Kelsey, Renato Talamini, Rolando Herrero, Silvia Franceschi, Tomoko Nukui, Shama Buch, Marjorie Romkes, Jingchun Luo, Mark C. Weissler, Andrew F. Olshan, Shu-chun Chuang, Amelie Chabrier, Graham Byrnes, Valerie Gaborieau, Therese Truong, and Dan Chen
- Abstract
Background: Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR = 1.24, P = 0.003) with little effect in men (OR = 1.04, P = 0.35).Methods: In a coordinated genotyping study within the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we have sought to replicate these findings in an additional 4,604 cases and 6,239 controls from 10 independent UADT cancer case–control studies.Results: rs16969968 was again associated with UADT cancers in women (OR = 1.21, 95% CI = 1.08–1.36, P = 0.001) and a similar lack of observed effect in men [OR = 1.02, 95% CI = 0.95–1.09, P = 0.66; P-heterogeneity (Phet) = 0.01]. In a pooled analysis of the original and current studies, totaling 8,572 UADT cancer cases and 11,558 controls, the association was observed among females (OR = 1.22, 95% CI = 1.12–1.34, P = 7 × 10−6) but not males (OR = 1.02, 95% CI = 0.97–1.08, P = 0.35; Phet = 6 × 10−4). There was little evidence for a sexdifference in the association between this variant and cigarettes smoked per day, with male and female rs16969968 variant carriers smoking approximately the same amount more in the 11,991 ever smokers in the pooled analysis of the 14 studies (Phet = 0.86).Conclusions: This study has confirmed a sex difference in the association between the 15q25 variant rs16969968 and UADT cancers.Impact: Further research is warranted to elucidate the mechanisms underlying these observations. Cancer Epidemiol Biomarkers Prev; 20(4); 658–64. ©2011 AACR.
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- 2023
44. Supplementary Figure 4 from Identification of an Epigenetic Profile Classifier That Is Associated with Survival in Head and Neck Cancer
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Karl T. Kelsey, Carmen J. Marsit, Brock C. Christensen, Heather H. Nelson, Michael D. McClean, E. Andrés Houseman, Rondi A. Butler, and Graham M. Poage
- Abstract
PDF file - 94K, Specificity analysis for survival association with PcG|MIR|TFBS locus methylation
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- 2023
45. Supplementary Table 2 from Biomarkers of HPV in Head and Neck Squamous Cell Carcinoma
- Author
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Karl T. Kelsey, Jeffrey F. Krane, Michael Pawlita, Tim Waterboer, Gordana Halec, E. Andres Houseman, Gregory A. Grillone, Richard O. Wein, John R. Clark, Robert I. Haddad, Brock C. Christensen, Heather H. Nelson, Michael D. McClean, Carmen J. Marsit, and Caihua Liang
- Abstract
PDF file - 62K, Concordance of the detecting markers in subset of subjects with complete data and HPV16 serological markers, Eastern Massachusetts, 1999-2003
- Published
- 2023
46. Supplementary Figure 2 from Identification of an Epigenetic Profile Classifier That Is Associated with Survival in Head and Neck Cancer
- Author
-
Karl T. Kelsey, Carmen J. Marsit, Brock C. Christensen, Heather H. Nelson, Michael D. McClean, E. Andrés Houseman, Rondi A. Butler, and Graham M. Poage
- Abstract
PDF file - 44K, Comparison of hyper- and hypomethylated CpG loci among each of the patient methylation subgroups
- Published
- 2023
47. Supplementary Figure 1 from Biomarkers of HPV in Head and Neck Squamous Cell Carcinoma
- Author
-
Karl T. Kelsey, Jeffrey F. Krane, Michael Pawlita, Tim Waterboer, Gordana Halec, E. Andres Houseman, Gregory A. Grillone, Richard O. Wein, John R. Clark, Robert I. Haddad, Brock C. Christensen, Heather H. Nelson, Michael D. McClean, Carmen J. Marsit, and Caihua Liang
- Abstract
PDF file - 35K, ROC curves for HPV assays. AUC=Area under the Curve. P=0.024 from the DeLong's tests comprising the AUCs of E7 and DNA (MPG); P=0.05 comparing the AUCs of E7 and L1 (MS)
- Published
- 2023
48. Supplementary Table 3 from Biomarkers of HPV in Head and Neck Squamous Cell Carcinoma
- Author
-
Karl T. Kelsey, Jeffrey F. Krane, Michael Pawlita, Tim Waterboer, Gordana Halec, E. Andres Houseman, Gregory A. Grillone, Richard O. Wein, John R. Clark, Robert I. Haddad, Brock C. Christensen, Heather H. Nelson, Michael D. McClean, Carmen J. Marsit, and Caihua Liang
- Abstract
PDF file - 63K, The association between selected markers and overall survival of HNSSC patients stratified by tumor sites, Eastern Massachusetts, 1999-2003
- Published
- 2023
49. Supplementary Table 1 from Identification of an Epigenetic Profile Classifier That Is Associated with Survival in Head and Neck Cancer
- Author
-
Karl T. Kelsey, Carmen J. Marsit, Brock C. Christensen, Heather H. Nelson, Michael D. McClean, E. Andrés Houseman, Rondi A. Butler, and Graham M. Poage
- Abstract
PDF file - 5K, Primers Used In Pyrosequencing Validation
- Published
- 2023
50. Supplementary Table 1 from Biomarkers of HPV in Head and Neck Squamous Cell Carcinoma
- Author
-
Karl T. Kelsey, Jeffrey F. Krane, Michael Pawlita, Tim Waterboer, Gordana Halec, E. Andres Houseman, Gregory A. Grillone, Richard O. Wein, John R. Clark, Robert I. Haddad, Brock C. Christensen, Heather H. Nelson, Michael D. McClean, Carmen J. Marsit, and Caihua Liang
- Abstract
PDF file - 64K, Characteristics among the whole cases and those with DNA or P16 detected, Eastern Massachusetts, 1999-2003
- Published
- 2023
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