Search

Mineralische Altbaustoffe bilden eine riesige Menge an Rohstoffen für die Bauwirtschaft. Diese Menge kann systematisch gehoben werden – zugunsten von Bauherren und vor allem der Umwelt.

Abstract. The term “exercise addiction” has been used in the scientific literature since the late 1970s. It is used to refer to persistent excessive exercise despite negative physical, psychological and social consequences, with unsuccessful attempts to reduce or stop the behavior. In this article, the evidence for exercise addiction as a behavioral addiction is presented. Symptoms and psychiatric comorbidities are explained, and recommendations for identification and treatment of exercise addiction are presented.

The production of mycotoxins is often interpreted as fungal response to cope with unfavorable growth conditions induced by toxic substances, environmental and biological factors. Soil covers influence soil environment, which consequently can change the abundance and composition of microbial communities. We investigated how plastic coverage (PC) influence soil fungi and mycotoxin occurrence (deoxynivalenol, nivalenol and zearalenone) compared to the traditional straw coverage (SC) in dependence of soil depth and time in a 3-year field experiment in strawberry cultivation. In total, 300 soil samples, resulting from two treatments, three soil layers, and ten sampling dates (n = 5), were analyzed for mycotoxins and ergosterol (proxy for soil fungal biomass) with liquid chromatography high resolution mass spectrometry and high-performance liquid chromatography with UV-detection, respectively. The modified microclimate under PC had no significant influence on fungal biomass, whereas SC promoted fungal biomass in the topsoil due to C-input. Mycotoxins were detected under both cover types in concentrations between 0.3 and 21.8 µg kg−1, mainly during strawberry establishment period and after fungicide application. Deoxynivalenol had the highest detection frequency with 26.3% (nivalenol: 8.3%, zearalenone: 8.7%). This study confirmed the in situ production of mycotoxins in soil, which seems mainly triggered by field treatment (fungicide application) and plant growth stage (establishment period) rather than on mulching type. Further investigations are necessary to better understand the influence of different agricultural practices and soil types on the production and fate of mycotoxins.

Isothermal microcalorespirometry is a non-destructive technique widely used to study terrestrial activity in ecosystems by measuring the heat and the carbon dioxide (CO2) released by metabolic reactions of soil organisms. Therefore, microbial communities naturally present in the soil play a key role in the C and N cycle thereby releasing heat and CO2 which are quantitatively related to the matter fluxes via the law of Hess. In order to measure both quantities simultaneously, current methods follow mainly a purely calorimetric approach (absorbent method or GC analysis) [1]. In the absorbent method, CO2 is measured indirectly via the heat released during the absorption reaction in a NaOH-solution (CO2-trap), which is placed in the sample vessel together with the soil sample. This approach presents a few disadvantages, e.g. indirect CO2 measurement, small sample size, low sample throughput, low CO2 partial pressure and oxygen limitation. To overcome the drawbacks of the current calorespirometric approach, a newly designed isothermal macrocalorespirometer (IMCR) was developed by combining a classic respirometer and the proven concept of isothermal microcalorimetry. The IMCR is composed of 10 mobile channels placed in a thermally isolated box, water-thermostated at 20°C. Each channel is composed of a heat sink and a heat sensor directly in contact with the sample vessel (calorimetric unit), plus a vessel with a KOH-solution (CO2-trap) in which a pair of electrodes is immersed (respirometric unit) connected to the channel’s lid. The spatial separation between the two units, the use of electrodes and the size of the channel, make it possible to overcome the disadvantages of the absorbent method (NaOH-solution) mentioned above. The new approach has been successfully tested with glucose-induced microbial metabolic activity in soil samples, allowing the quantification of the calorespirometric ratio . Additionally, TGA-DSC-MS and GC-MS analysis will be performed, necessary to close balances of mass and energy fluxes.This newly designed IMCR will be applied in the wider frame of calorimetric environmental soil studies, aiming at understanding the carbon dynamics in soil, the latter being known as the biggest carbon pool among the natural matrix. New knowledge in this area support potential solutions for climate change, intimately connected to the global carbon fluxes.[1] Wadsö L., A method for time-resolved calorespirometry of terrestrial samples, Methods 76 (2015) 20–2

BackgroundCannabis is the most widely used illicit substance. Various countries have legalized cannabis for recreational use. Evidence on the health effects of cannabis regulation remains unclear and is mainly based on observational studies. To date, there is no randomized controlled study evaluating the impact of cannabis regulation for recreational use compared to the illicit market on relevant health indicators. The present study (“Weed Care”) is the first to evaluate the impact of regulated cannabis access in pharmacies versus a waiting list control group representing the illicit market on problematic cannabis use as well as on mental and physical health.MethodsThe study is divided into two parts—a randomized controlled study of 6 months followed by an observational study of 2 years. Participants (N = 374) are randomly assigned to either the experimental group with access to legal cannabis in pharmacies or to the waiting list control group representing the current legal framework in Switzerland, namely the illicit market. After 6 months, all participants will have access to legal cannabis for the following 2 years (observational study). The primary outcome is problematic cannabis use as measured with the Cannabis Use Disorders Identification Test-Revised (CUDIT-R). Secondary outcomes are cannabis use patterns, mental disorders (e.g., depression, anxiety, and psychosis) and physical health (e.g., respiratory symptoms). Primary and secondary outcomes will be assessed online every 6 months. The study is approved by the responsible ethics committee as well as by the Swiss Federal Office of Public Health.DiscussionFindings from this study may provide a scientific basis for future discussions about addiction medicine and cannabis policy in Switzerland.Clinical Trial RegistrationClinicalTrials.gov (NCT05522205). https://clinicaltrials.gov/ct2/show/NCT05522205

Background Heroin-assisted treatment (HAT) is a proven effective treatment option for individuals with severe opioid use disorder (OUD). In Switzerland, pharmaceutical heroin (diacetylmorphine, DAM) is available in tablet form or as injectable liquid. This creates a large barrier for individuals who require the rapid onset of effect but are either unable or do not want to inject, or who primarily snort opioids. Early experimental data has demonstrated that intranasal DAM administration can be a viable alternative to the intravenous or intramuscular route of administration. The purpose of this study is to assess the feasibility, safety, and acceptability of intranasal HAT. Methods This study will assess intranasal DAM using a prospective multicentre observational cohort study design in HAT clinics across Switzerland. Patients will be offered to switch from oral or injectable DAM to intranasal DAM. Participants will be followed-up over 3 years, with assessments at baseline, and after 4, 52, 104 and 156 weeks. The primary outcome measure (POM) is retention in treatment. Secondary outcomes (SOM) include prescriptions and routes of administration of other opioid agonists, illicit substance use, risk behaviour, delinquency, health and social functioning, treatment adherence, opioid craving, satisfaction, subjective effects, quality of life, physical health, and mental health. Conclusions The results derived from this study will generate the first major body of clinical evidence on the safety, acceptability, and feasibility of intranasal HAT. If proven to be safe, feasible and acceptable, this study would increase the accessibility of intranasal OAT for individuals with OUD globally as a critical improvement in risk reduction.

Background: Opioid agonist treatment (OAT) comprises the use of opioid agonists to replace illicit street opioids and is the treatment of choice for individuals with opioid use disorder (OUD). We aim to systematically review the risk for any type of adverse effects of OAT in patients with opioid use disorder.Methods: We aim to inform evidence-based care decisions with a systematic review of published randomised controlled trials (RCTs) evaluating opioid agonists for the treatment of OUD in comparison to any control and reporting adverse effects. The search strategy was developed and peer-reviewed by medical information specialists. The databases Embase, Medline, PsycInfo, CENTRAL, and the Web of Science Core Collection will be searched without date limits. Title and abstract screening will be done in duplicate by three and full text screening by two independent reviewers. Data extraction will be checked by a second reviewer. Disagreements will be resolved by a third reviewer.We aim to combine study results in random-effects meta-analyses and calculate relative and absolute risks.Risk of bias will be assessed with version 2 of the Cochrane risk-of-bias tool for randomized trials (RoB 2).An assessment of quality of evidence will be conducted using the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) framework.Discussion: The results of this systematic review will provide evidence to allow optimal clinical decision making for patients with OAT, in particular those with previous adverse events.

The Sydney Children’s Hospitals Network addressed the challenges of the COVID-19 pandemic by implementing innovative changes which made their health system resilient and responsive. For other health care systems, there are important takeaways. In the US and Canada, an urgent widespread response is needed to address the overdose crisis, driven by potent synthetic opioids (i.e., fentanyl and its derivates). We project the COVID-19 System Shock Framework on to the North American healthcare systems and suggest a Fentanyl System Shock Framework, which provides a framework for necessary changes and innovations to address the overdose crisis. To become resilient to the fentanyl system shock, core components as well as overarching values, health policy, and online technologies need to be adapted to reduce the death count and meet the evolving needs of marginalised individuals who use opioid. Future research should focus on scientifically assessing such implementations to guide evidence-based decision making.

Introduction: Given the increasing global burden of mental illness, the existing shortage of psychiatrists internationally is a concerning development with a deteriorating trajectory. In 2016, only 5% of US medical students considered a career in psychiatry, and the situation is similar in other areas (e.g., European countries). Attracting medical students to the field of psychiatry is evidently necessary. This paper investigates European medical students’ attitudes towards psychiatry, their intentions to pursue psychiatry as a career, and the role of different factors such as personal experience and education on their interest in psychiatry. Methods: A cross-sectional survey was analyzed from 799 medical students in two European countries. Data was collected in 2016. Participants completed a survey on their attitudes towards psychiatry, their medical education regarding psychiatry, and personal experiences. Cross tabulations with chi-square tests were performed for inferential analyses using a significance level of 0.05. Results: The number of years spent in medical school, the students’ personal experiences, and the perceived quality of education was significantly associated with specialty choice and ranking of psychiatry relative to other specialties. Students’ exposure to internships, psychiatric placements, and their view on psychiatric instructors also played a significant role in choosing psychiatry as a profession. Conclusions: The systematic evaluation of students’ attitudes towards psychiatry and motivational factors for pursuing psychiatry as a specialty, such as psychiatric education in medical school and personal experience, can inform necessary changes in the recruitment of students to the field. Efforts must address the worldwide shortage of psychiatrists to effectively reduce the burden of disease associated with mental health and substance use.

Background and AimsSexual dysfunctions (SDs) show a marked impact on a person’s general wellbeing. Several risk-factors like physical and mental illnesses as well as alcohol and tobacco use have to date been identified to contribute to the occurrence of SDs. The impact of opioid-agonist treatment (OAT) on SDs remains unclear, with some studies demonstrating an improvement after methadone maintenance treatment (MMT) initiation. However, no studies on the prevalence and predictors of SDs in heroin-assisted treatment (HAT) exist to date.MethodsA cross-sectional study was conducted with patients from a MMT center (n = 57) and a center specializing in HAT (n = 47). A control group of patients with mild transient illnesses (n = 67) was recruited from a general practitioner (GP). The International Index of Erectile Function, the Female Sexual Function Index, as well as measurements for psychological distress, depressive state, nicotine dependence, and high-risk alcohol use were employed. Patients also completed a self-designed questionnaire on help-seeking behavior regarding sexual health. Mann-Whitney-U tests and chi-square tests were performed for group comparisons and binary logistic regression models were calculated.ResultsTwenty-five percent of the GP sample (n = 17), 70.2% (n = 40) of the MMT sample, and 57.4% (n = 27) of the HAT sample suffered from SDs at the time of study conduction. OAT patients differed significantly from GP patients in depressive state, high-risk alcohol use, nicotine dependence, and psychological distress. Age, depressive state, and opioid dependence predicted the occurrence of SDs in the total sample. No differences between OAT and GP patients were found regarding help-seeking behavior.DiscussionAge, depressive state, and opioid dependence predicted the occurrence of SDs in the total sample. It remains unclear whether SDs are caused by opioid intake itself or result from other substance-use related lifestyle factors, that were not controlled for in this study. A lack of help-seeking behavior was observed in our sample, underlining the importance of clinicians proactively inquiring about the sexual health of their patients.ConclusionThe high prevalence of SDs observed in MMT does not differ from the prevalence in HAT. Clinicians should actively inquire about their patients’ sexual health in GP and OAT centers alike.

Adolescence and emerging adulthood are often referred to as youth. Transitional psychiatry addresses this target group, which considers patients between 15 and 25 years of age. Substance use usually begins and peaks at this stage of life. Psychiatric disorders, foremost attention-deficit/hyperactivity disorder, and affective disorders, conduct disorders, and first-episodes psychosis frequently appear in early life stages. This review aims to provide a broad overview of transitional-aged youth's most common psychiatric comorbidities with substance use disorders. A literature search was conducted in Embase and Pubmed, and the main findings are described narratively. We present main findings for the following comorbidities: attention-deficit/hyperactivity disorder, conduct disorder, personality disorders, affective disorders, psychotic disorders, and the phenomena of overdose and suicidality. In conclusion, co-occurring mental health disorders are common and appear to facilitate the development of substance use disorders and exacerbate their overall course. Substance use also affects the severity and course of comorbid psychiatric disorders. Overall, data on transition-age youth with substance use disorders are highly inconsistent. Universal screening and treatment guidelines do not yet exist but should be aimed for in the future.

Background Heroin-assisted treatment has proven effective in reducing criminal offenses in opioid dependent individuals. Few studies attempted to explain the observed crime reduction and the reasons why these patients keep offending and getting incarcerated have to date not been explored. Methods Patients with a history of incarcerations during the time of participating in heroin-assisted treatment (n = 22) were invited to a semi-structured, narrative interview. Findings were evaluated with Mayring’s qualitative content analysis framework. Additionally, the Montreal Cognitive Assessment test and the multiple-choice vocabulary intelligence test used to assess cognitive impairment and premorbid intelligence levels. Results Three main categories emerged in patients’ narratives on their incarcerations: cocaine use, impaired functioning, and financial constraints. Lifetime prevalence of cocaine use disorder was 95.5% and their cocaine use often led to patients getting incarcerated. Impaired functioning mainly constituted the inability to receive and open mail. Financial constraints led to incarcerations in lieu of payment in 16 participants (72.7%). Categories overlapped notably and often occurred in close temporal proximity. A fourth category on the likelihood of getting incarcerated again in the future was inhomogeneous and ranged from the strong conviction to complete rejection of the scenario. Average premorbid intelligence levels were found, whereas the cognitive assessment suggested severe cognitive impairment in our sample. Conclusion Participants mainly reported to have committed minor offenses and not being able to pay for resulting fines. The resulting prison sentences are an unconvincing practice from a medical and economic perspective alike. Public expenditure and the interruptions of the continuum of care could be reduced by legislatively protecting these marginalised patients.

Die Qualitat der therapeutischen Beziehung ist pradiktiv fur den Therapieerfolg und der groste Einflussfaktor, der diesbezuglich isoliert untersucht wurde. In der Allgemeinpsychiatrie existieren verschiedene Beziehungsmodelle, deren Operationalisierungen als Messinstrumente Verwendung finden. Aufgrund der Vorhersagekraft dieser Fragebogen fur den Therapieerfolg in der allgemeinen Psychotherapie ist es sinnvoll, die therapeutische Beziehung auch in der forensischen Psychiatrie zu operationalisieren. Die vorliegende systematische Ubersichtsarbeit untersuchte die Besonderheiten und Unterschiede validierter Messinstrumente zur Erfassung der therapeutischen Beziehung bei unfreiwillig behandelten psychiatrischen Patienten. Dabei zeigte sich, dass die ublichen Beziehungskonzepte im forensischen Kontext stark adaptiert werden mussen. Die wenigen vorliegenden Messinstrumente sind in der Lage, forensische von allgemeinpsychiatrischen Patienten zu unterscheiden, wenn sie die „Strenge“ des Therapeuten als zusatzliche eigene Beziehungsdimension berucksichtigen. Zudem sind diese, anders als Fragebogen der allgemeinen Psychotherapie, pradiktiv fur die strafrechtliche Ruckfalligkeit der Patienten. Die gemeinsame Einigung auf Therapieziele und therapeutische Aufgaben ist in der Forensik weniger relevant fur eine gute Beziehungsqualitat. Diese profitiert am ehesten von einem bestimmten und direktiven Stil, mit klar definierten Rollen und einem „Hart-aber-fair-Prinzip“.

The treatment of patients with schizophrenia and substance use disorder poses a challenge for clinicians. Continued use of cannabis and cocaine can exacerbate psychotic symptoms and worsen the course of disease. To date, no pharmacotherapy is available for patients with cannabis use disorder (CUD). Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) are the main active constituents in Cannabis sativa, with the latter being linked to an increased risk of psychosis. We describe a clinical case of a male patient diagnosed with schizophrenia, combined personality disorder, CUD and cocaine use disorder. Over the course of 8 years, he was hospitalized 30 times due to psychotic relapses and continued substance use. Consequently, CBD cigarettes with a low THC content (

Heroin-assisted treatment comprises the use of diacetylmorphine (pharmaceutical heroin) for individuals with severe opioid use disorder. In Switzerland, take-home doses in heroin-assisted treatment are more strictly regulated as compared to conventional opioid agonist treatment. In light of the COVID-19 pandemic, the Swiss Federal Council provisionally adapted its policy, allowing for longer prescriptions of take-home diacetylmorphine. Before the beginning of the pandemic, take-home doses only occurred in exceptional circumstances and under strict criteria for patient eligibility. Following the legislative adaptations, we critically revised our internal centre policies as well. We report our experiences with oral take-home diacetylmorphine from a Swiss outpatient university centre specialising in heroin-assisted treatment. An additional 45 patients received take-home doses following the first lockdown. While some patients wished to return to their previous treatment regimen, most patients managed their medication well and showed good adherence. We also noticed an increase of treatment admissions that are likely related to the relaxed regulations. Previously, the strict therapeutic framework of visiting a HAT centre twice a day for supervised dispensing seemed to have discouraged these individuals from seeking medical treatment. From a medical point of view, the politically driven restrictions on take-home doses in heroin-assisted treatment are questionable and do not support the goal of harm reduction.

trans-Selective hydrocyanation of ynoates and ynones in the presence of TMSCN and an alcohol additive are catalyzed by nucleophilic phosphines. The trisubstituted E-olefin products of anti-addition of hydrogen cyanide to the alkyne are produced with high regio- and stereoselectivity. The alcohol additive reacts with TMSCN to produce hydrogen cyanide in situ. Ynoic acids undergo the phosphine catalyzed hydrocyanation in the presence of TMSCN under aprotic conditions only. In these reactions, TMSCN reacts with the acid to generate hydrogen cyanide and the silyl ester which, unlike the acid, undergoes phosphine catalyzed hydrocyanation and gives the stereo-defined E-2-cyano-acrylic acids after work up.

Initiatives to promote community-based natural resource management (CBNRM) have been evaluated with mixed results in socio-economic and ecological outcome dimensions. In Namibia, community conservancies are being established since the 1990s mainly to reconcile wildlife conservation and rural development. As Namibia gears up for participation in Reducing Emissions from Deforestation and Forest Degradation (REDD+), land use and land cover change and related biomass carbon dynamics may become increasingly important additional outcome indicators for the country's approach to CBNRM. Based on a social-ecological conceptual framework, we identify spatially heterogeneous local context factors that may drive positive and negative effects of CBNRM on vegetation cover in Namibia's Zambezi region. We test our theoretical predictions using panel data in a spatially explicit, quasi-experimental evaluation design and find that, on average, CBNRM somewhat increased elephant presence, but had a negative effect on woodland cover. Heterogeneous treatment effect analysis indicates that CBNRM does work for woodland conservation when communities are located in and around wildlife corridors, which provide tourism income opportunities. Despite success in stabilizing wildlife populations in the region, our results suggest that complementary conservation incentives may be required to make Namibia's CBNRM model fit for REDD+.

Community-bsased Conservation seeks to strike a balance between nature conservation and economic growth by establishing spatial and institutional settings that maintain and even regain biodiversity while simultaneously allowing for sustainable land use. The implementation of community-based conservation blueprints on communal, often agronomically marginal lands, is in many southern and eastern African countries encouraged by the national government. Despite vast academic literature on community-based conservation, it remains unclear how this re-shaping of resource governance has driven territorialisation in rural areas. To address this gap, this article compares the implementation of community-based conservation in Northern Kenya and Northern Namibia. By doing so, we intend to shed light on the question 'why does community-based conservation result in different forms of territorialisation negotiated between state agencies, non-governmental organisations and rural communities? We demonstrate how historical preconditions, contemporary project design, and the commodification of natural resources shape territorialisation in both cases in different ways. In Kenya, concerns for securitisation have been driving community-based conservation, while in Namibia it primarily aimed to benefit the previously disadvantaged rural residents. Furthermore, in both regions community-based conservation programmes serve as vehicles to articulate political claims, either to reify traditional authorities, to create ethnically homogenous territories or to define boundaries of resource use.

Growing bioenergy crops on degraded and underutilized land is a promising solution to meet the requirement for energy security, food security, and land restoration. This paper assesses the socioeconomic and environmental benefits of agroforestry systems based on nyamplung (tamanu) (Calophyllum inophyllum L.) in the Wonogiri district of Central Java, Indonesia. Data were collected through field observations and focus group discussions involving 20 farmers who intercrop nyamplung with maize, rice, and peanuts and utilize the species in honey production. Calculating each crop's net present value (NPV) demonstrates that when grown as monocultures, staple crops rice and peanuts lead to negative profitability, while maize generates only a marginal profit; yet honey production utilizing nyamplung produces a NPV nearly 300 times greater than maize. However, when utilizing nyamplung, honey is also the commodity most sensitive to decreases in production, followed by nyamplung–peanut and nyamplung–rice combinations. While decreases in production have little effect on the NPVs of rice, peanuts, and maize, these annual crops can only be cultivated for a maximum of 6 years within the nyamplung's 35‐year cycle, due to canopy closure after this time. Nyamplung‐based agroforestry systems can provide economic, social, and environmental gains on different scales. However, when considering the high profit potential of nyamplung combined with honey production, further research is needed to improve and develop bee husbandry practices so this becomes a viable option for local farmers.

Autonomous driving is one of the major trends in mobility for the past decade as well as for the upcoming years. In order to realize a fully automated vehicle steering a detailed representation about the cars environment is of crucial importance. This is only possible with reconstruction systems allowing dense reconstruction grids combining trustworthiness of the data, based on redundant information.

Lack of the mitochondrial deacetylase sirtuin 3 (SIRT3) impairs mitochondrial function and increases the susceptibility to induction of the mitochondrial permeability transition pore. Because these alterations contribute to myocardial ischemia–reperfusion (IR) injury, we hypothesized that SIRT3 deficiency may increase cardiac injury following myocardial IR. Hearts of 10-week-old mice were perfused in the isolated working mode and subjected to 17.5 min of global no-flow ischemia, followed by 30 min of reperfusion. Measurements before ischemia revealed a decrease in cardiac power (–20%) and rate pressure product (–15%) in SIRT3−/− mice. Mitochondrial state 3 respiration (–15%), ATP synthesis (–39%), and ATP/O ratios (–29%) were decreased in hearts of SIRT3−/− mice. However, percent recovery of cardiac power (WT 94% ± 9%; SIRT3−/− 89% ± 9%) and rate pressure product (WT 89% ± 16%; SIRT3−/− 96% ± 3%) following IR was similar in both groups. Myocardial infarct size was not increased in SIRT3−/− mice following permanent ligation of the left anterior descending coronary artery (LAD). Left ventricular pressure and dP/dtmax, and mitochondrial respiration and ATP synthesis were not different between groups following LAD ligation. Thus, despite pre-existing defects in cardiac function and mitochondrial respiratory capacity in SIRT3−/− mice, SIRT3 deficiency does not additionally impair cardiac function following IR or following myocardial infarction.

Sirtuin 3 (SIRT3) is a mitochondrial NAD(+)-dependent deacetylase that regulates energy metabolic enzymes by reversible protein lysine acetylation in various extracardiac tissues. The role of SIRT3 in myocardial energetics and in the development of mitochondrial dysfunction in cardiac pathologies, such as the failing heart, remains to be elucidated. To investigate the role of SIRT3 in the regulation of myocardial energetics and function SIRT3(-/-) mice developed progressive age-related deterioration of cardiac function, as evidenced by a decrease in ejection fraction and an increase in enddiastolic volume at 24 but not 8 weeks of age using echocardiography. Four weeks following transverse aortic constriction, ejection fraction was further decreased in SIRT3(-/-) mice compared to WT mice, accompanied by a greater degree of cardiac hypertrophy and fibrosis. In isolated working hearts, a decrease in cardiac function in SIRT3(-/-) mice was accompanied by a decrease in palmitate oxidation, glucose oxidation, and oxygen consumption, whereas rates of glycolysis were increased. Respiratory capacity and ATP synthesis were decreased in cardiac mitochondria of SIRT3(-/-) mice. HPLC measurements revealed a decrease of the myocardial ATP/AMP ratio and of myocardial energy charge. Using LC-MS/MS, we identified increased acetylation of 84 mitochondrial proteins, including 6 enzymes of fatty acid import and oxidation, 50 subunits of the electron transport chain, and 3 enzymes of the tricarboxylic acid cycle. Lack of SIRT3 impairs mitochondrial and contractile function in the heart, likely due to increased acetylation of various energy metabolic proteins and subsequent myocardial energy depletion.

Die Schlagzeilen des Jahres 2010 machten den Zustand der Deutschen Bahn AG drastisch sichtbar: Zusammenbruch des S-Bahnverkehrs in Berlin, Konstruktionsmängel in mehreren Fahrzeugbaureihen, hunderte Zugausfälle in Sommer und Winter. Einen Hinweis auf die politischen Entscheidungen, die zu diesem Zustand der Bahn geführt haben, sucht man in der Berichterstattung aber meist vergebens. Mit der 1994 eingeleiteten Bahnreform waren große Hoffnungen für die Zukunft des Verkehrsträgers Bahn verknüpft. Die zentralen Reforminhalte, Marktöffnung und formelle Privatisierung der DB sind jedoch nicht dazu geeignet, die Wettbewerbsposition der Bahn zu verbessern. Maximilian Meyer zeigt anschaulich, warum die Bahnreform scheitern musste, welche Alternativen es gibt und warum die Bahnprivatisierung die falsche Antwort auf die Misere des Schienenverkehrs ist.