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Additional file 1.

Supplemental material, sj-pdf-2-spo-10.1177_17479541211056398 for The importance of aerobic capacity and nutrition in recreational master mountain runners��� performance and race-induced changes in body composition and biochemical blood indices by Spyridon Methenitis, Evgenia D. Cherouveim, Christos Kroupis, Argyrios Tsantes, Kleopatra Ketselidi, Elpiniki Vlachopoulou, George Stavroulakis, Andreas Mavrogenis, Charilaos Tsolakis and Panagiotis Koulouvaris in International Journal of Sports Science & Coaching

Supplemental material, sj-pdf-3-spo-10.1177_17479541211056398 for The importance of aerobic capacity and nutrition in recreational master mountain runners��� performance and race-induced changes in body composition and biochemical blood indices by Spyridon Methenitis, Evgenia D. Cherouveim, Christos Kroupis, Argyrios Tsantes, Kleopatra Ketselidi, Elpiniki Vlachopoulou, George Stavroulakis, Andreas Mavrogenis, Charilaos Tsolakis and Panagiotis Koulouvaris in International Journal of Sports Science & Coaching

Supplemental material, sj-pdf-5-spo-10.1177_17479541211056398 for The importance of aerobic capacity and nutrition in recreational master mountain runners��� performance and race-induced changes in body composition and biochemical blood indices by Spyridon Methenitis, Evgenia D. Cherouveim, Christos Kroupis, Argyrios Tsantes, Kleopatra Ketselidi, Elpiniki Vlachopoulou, George Stavroulakis, Andreas Mavrogenis, Charilaos Tsolakis and Panagiotis Koulouvaris in International Journal of Sports Science & Coaching

Supplemental material, sj-pdf-3-spo-10.1177_17479541211056398 for The importance of aerobic capacity and nutrition in recreational master mountain runners��� performance and race-induced changes in body composition and biochemical blood indices by Spyridon Methenitis, Evgenia D. Cherouveim, Christos Kroupis, Argyrios Tsantes, Kleopatra Ketselidi, Elpiniki Vlachopoulou, George Stavroulakis, Andreas Mavrogenis, Charilaos Tsolakis and Panagiotis Koulouvaris in International Journal of Sports Science & Coaching

Supplemental material, sj-pdf-4-spo-10.1177_17479541211056398 for The importance of aerobic capacity and nutrition in recreational master mountain runners��� performance and race-induced changes in body composition and biochemical blood indices by Spyridon Methenitis, Evgenia D. Cherouveim, Christos Kroupis, Argyrios Tsantes, Kleopatra Ketselidi, Elpiniki Vlachopoulou, George Stavroulakis, Andreas Mavrogenis, Charilaos Tsolakis and Panagiotis Koulouvaris in International Journal of Sports Science & Coaching

Supplemental material, sj-pdf-4-spo-10.1177_17479541211056398 for The importance of aerobic capacity and nutrition in recreational master mountain runners��� performance and race-induced changes in body composition and biochemical blood indices by Spyridon Methenitis, Evgenia D. Cherouveim, Christos Kroupis, Argyrios Tsantes, Kleopatra Ketselidi, Elpiniki Vlachopoulou, George Stavroulakis, Andreas Mavrogenis, Charilaos Tsolakis and Panagiotis Koulouvaris in International Journal of Sports Science & Coaching

Supplemental material, sj-pdf-2-spo-10.1177_17479541211056398 for The importance of aerobic capacity and nutrition in recreational master mountain runners��� performance and race-induced changes in body composition and biochemical blood indices by Spyridon Methenitis, Evgenia D. Cherouveim, Christos Kroupis, Argyrios Tsantes, Kleopatra Ketselidi, Elpiniki Vlachopoulou, George Stavroulakis, Andreas Mavrogenis, Charilaos Tsolakis and Panagiotis Koulouvaris in International Journal of Sports Science & Coaching

Additional file 1: Appendix. Patients characteristics of included or excluded patients in this study.

The aim of the present study is to control the hypothesis that the rib hump deformity can be adequately corrected when applying vertebral derotation. We retrospectively studied patients treated with full pedicle screw systems (group A), hybrid constructs (group B), and Harrington rod instrumentation (group C). No costoplasties were performed in the patients included in our study. Derotation was applied in groups A and B. The rib hump deformity was assessed on lateral radiographic studies by rib index (RI). Of the 72 patients that were finally included in our study, 30 patients (24 females and 6 males; mean age, 14.5 ± 2.2 years) were treated with a full pedicle screw system, 23 patients (19 females and 4 males; mean age, 13.8 ± 1.9 years) were treated with a hybrid construct, and 19 patients (16 females and 3 males; mean age, 14.3 ± 2 years) received the Harrington rod instrumentation. In all groups RI was significantly corrected after surgery. Before surgery no difference in RI was found among groups; however, after surgery RI was found significantly higher in group C as compared to groups A and B. The between-group analysis revealed that the correction of RI, and thereby the rib hump deformity correction, did not significantly differ among the three patient groups. In conclusion, it cannot be suggested based on the present study that vertebral derotation alone can offer an adequate correction of the rib hump deformity. Further, the development of rib cage deformity and its degree of interdependence with the scoliotic spinal deformity has to be further investigated and assessed, as it seems that it may not necessarily result directly from the primary vertebral deformity.

Supplemental material, sj-pdf-5-spo-10.1177_17479541211056398 for The importance of aerobic capacity and nutrition in recreational master mountain runners��� performance and race-induced changes in body composition and biochemical blood indices by Spyridon Methenitis, Evgenia D. Cherouveim, Christos Kroupis, Argyrios Tsantes, Kleopatra Ketselidi, Elpiniki Vlachopoulou, George Stavroulakis, Andreas Mavrogenis, Charilaos Tsolakis and Panagiotis Koulouvaris in International Journal of Sports Science & Coaching

Angiosarcoma of bone is a rare high-grade malignant vascular tumor accounting for

Surgically accessible aneurysmal bone cysts (ABC) have traditionally been treated with curettage. Selective arterial embolization was initially proposed as a preoperative adjuvant to reduce peroperative bleeding. Currently, the role of embolization has been extended to the definitive treatment of aneurysmal bone cyst of the spine in children, as well as to other locations in the skeleton. The authors describe the technique in a 15-year-old girl with a T2 aneurysmal bone cyst. Digital subtraction angiography was performed for tumor vascular mapping, followed by selective arterial embolization with N-butyl 2 cyanoacrylate (NBCA). Because of persistent local pain, repeat embolization was done at 8 months. Pain relief and progressive ossification of the lesion were now observed. At 4-year follow-up, the patient was asymptomatic, with complete ossification of the lesion. Selective arterial embolization (SAE) is a minimally invasive, safe and effective procedure for the permanent occlusion of the pathological feeding vessels of spinal ABC. It should be considered as the treatment of choice for lesions difficult to access with surgery, especially in young patients. Careful pre-embolization vascular mapping of the lesion, operator's experience and use of NBCA are the keys to success.

Limited data are available for the diagnosis of patients with tumors with infected endoprosthetic reconstructions. The purpose of this study was to evaluate whether sonication is effective for the diagnosis of infection and to compare it with tissue cultures. The files of 58 patients who underwent revision surgery for suspected infected endoprosthetic reconstructions were reviewed. Cultures were performed on 5 tissue samples obtained from each patient and on fluid obtained by sonication of the megaprosthesis. The sensitivity, specificity, and negative and positive predictive values of tissue and sonication fluid cultures were evaluated. Overall, tissue and sonication fluid cultures confirmed an infection in 42 of the 58 patients. In 36 of the 42 infected endoprosthetic reconstructions, tissue and sonication fluid cultures identified the same bacterial isolate. In 5 cases, a bacterial isolate was identified only in sonication fluid cultures, and in 1 case, a bacterial isolate was identified only in tissue cultures. The sensitivity and negative predictive value of sonication fluid cultures were statistically significantly better than those of tissue cultures, while the specificity and positive predictive value were not different between the 2 culture types. Compared with tissue cultures for the diagnosis of infected megaprostheses in patients with tumors, sonication fluid cultures are associated with a better sensitivity and negative predictive value and a similar specificity and positive predictive value. Therefore, sonication should be considered a useful adjunct for the optimal diagnosis and management of these patients. [ Orthopedics . 2019; 42(1):28–32.]

Purpose: There are conflicting reports on the effect of denosumab on lung metastases in patients with giant cell tumor (GCT) of bone. To address these reports, we performed this study to determine if denosumab prevents lung metastasis and to evaluate univariate and multivariate predictors for lung metastases in these patients. Materials and methods: We retrospectively studied 381 GCT patients with surgery alone and 30 GCT patients with surgery and denosumab administration. The median follow-up was 85.2months (IQR, 54.2–124.4months). We evaluated lung metastases and local recurrences, univariate and multivariate predictors for lung metastases, response, and adverse events of denosumab administration. Results: The occurrence of lung metastases was similar (surgery alone 4.7%, 18 patients; denosumab administration 3.3%, 1 patient); however, the occurrence of local recurrences was significantly higher in the patients with denosumab administration. Denosumab administration was not an important predictor for lung metastases; Campanacci stage and type of surgery were the only univariate predictors for lung metastases, and type of surgery and local recurrence were the only multivariate predictors for lung metastases. Histology showed viable tumour in all tumor specimens of the patients with denosumab administration. Conclusion: Denosumab does not decrease the risk of lung metastases in patients with bone GCT; the only important predictors for lung metastases in these patients are type of surgery and local recurrence. However, because the number of patients with lung metastases was small for a multivariate analysis, the possibility of denosumab’s effect could not be completely eliminated.

Angiosarcoma of bone is a rare high-grade malignant vascular tumor accounting for

This study reviewed the medical records of 90 patients with lipomas (47 patients) and atypical lipomatous tumors (ALT)/well-differentiated liposarcomas (WDL) (43 patients) of the extremities treated from 2006 to 2012. All patients had preoperative biopsy and postoperative histologic analysis of the tumors; surgical margins were marginal in all cases. Histologic sections of the tissue blocks from the excised specimens were re-reviewed for all patients; a consensus with postoperative histologic analysis was confirmed. Molecular chromosome analysis was performed on fluorescence in situ hybridization in tissue sections from the tissue blocks in all cases for the purpose of this study; a ratio greater than 2 was considered to represent murine double-minute 2 (MDM2) amplification consistent with a diagnosis of ALT/WDL. Mean follow-up was 52 months (range, 14–96 months). Local recurrence and metastasis rates and the relationship of patient age and sex with tumor size and location were evaluated. None of the patients with lipomas experienced local recurrence compared with 6 patients (13.9%) with ALT/WDL who experienced local recurrence within a mean of 48 months (range, 33–96 months); this difference was statistically significant. None of the patients in either group experienced metastasis prior to the study period. Local recurrence did not correlate statistically with patient age or sex, or with tumor size or location. [ Orthopedics. 2016; 39(4):e610–e614.]