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Your search keyword '"Maugeri, Domenico"' showing total 3 results
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3 results on '"Maugeri, Domenico"'

2. Consensus Document on substitution therapy with DHEA in the elderly

Author

Valenti, Giorgio, Denti, Licia, Saccò, Marcella, Ceresini, Graziano, Bossoni, Simonetta, Giustina, Andrea, Maugeri, Domenico, Giovanni Vigna, Fellin, Renato, Paolisso, Giuseppe, Barbagallo, Mario, Maggio, Marcello, Strollo, Felice, Bollanti, Lucilla, Romanelli, Francesco, Latini, Maurizio, VALENTI G, DENTI L, SACCO M, CERESINI G, BOSSONI S, GIUSTINA A, MAUGERI D, VIGNA GB, FELLIN R, PAOLISSO G, BARBAGALLO M, MAGGIO M, STROLLO F, BOLLANTI L, ROMANELLI F, and LATINI F

Subjects
Adult, Male, Aging, medicine.medical_specialty, Hormone Replacement Therapy, Alternative medicine, Socio-culturale, Aged, Aged, 80 and over, Atherosclerosis, Bone Diseases, Metabolic, Cognition Disorders, Dehydroepiandrosterone, Female, Humans, Italy, Middle Aged, 80 and over, Adrenal insufficiency, Medicine, Substitution therapy, Intensive care medicine, business.industry, Geriatrics gerontology, medicine.disease, Consensus Document, elderly, adrenal insufficiency, adrenopause, DHEA, DHEAS, DHEA substitution therapy, Physical therapy, Metabolic, Bone Diseases, Geriatrics and Gerontology, business
Published
2006

3. The Italian observational study on severe osteoporosis (ISSO): 24-month results on incidence of fractures and adherence to treatment

Author

Idolazzi, L., Maugeri, D., Monti, S., Massarotti, M., Osella, G., Barbagallo, M., Del Fiacco, R., Silvestri, S., Adami, S., Altomonte, L., Bardoscia, A., Bertoldo, F., Bevilacqua, M., Bianchi, G., Brancati, A., Cagnoni, C., Cantatore, F. P., Capone, A., Costanzo, G., D Avola, G., Giorgi, G., Di Matteo, L., Di Munno, O., Filipponi, P., Frisina, N., Fusco, A., Giannini, S., Guiducci, S., Iolascon, G., Isaia, G., Lombardi, G., Malavolta, N., Marcocci, C., Migliaccio, S., Migliore, A., Muratore, M., Nardi, A., Ortolani, S., Pasquali, R., Petto, H., Pietrogrande, L., Pola, E., Previti, B., Resmini, G., Alessandro Rubinacci, Russo, E., Scillitani, A., Silveri, F., Leali, P. T., Trotta, F., Ulivieri, M., Verdoia, C., Versace, F., Vinicola, V., Idolazzi, Luca, Maugeri, Domenico, Monti, Salvatore, Massarotti, Marco, Osella, Giangiacomo, Barbagallo, Mario, Del Fiacco, Romano, Silvestri, Sandra, Adami, Silvano, Altomonte, Lorenzo, Bardoscia, Alfredo, Bertoldo, Francesco, Bevilacqua, Maurizio, Bianchi, Gerolamo, Brancati, Annamaria, Cagnoni, Carlo, Cantatore, Francesco Paolo, Capone, Antonio, Costanzo, Giuseppe, D'Avola, Giovanni, De Giorgi, Giuseppe, Di Matteo, Luigi, Di Munno, Ombretta, Filipponi, Paolo, Frisina, Nicola, Fusco, Alessandra, Giannini, Sandro, Guiducci, Serena, Iolascon, Giovanni, Isaia, Giancarlo, Lombardi, Gaetano, Malavolta, Nazzarena, Marcocci, Claudio, Migliaccio, Silvia, Migliore, Alberto, Muratore, Maurizio, Nardi, Alfredo, Ortolani, Sergio, Pasquali, Renato, Petto, Helmut, Pietrogrande, Luca, Pola, Enrico, Previti, Baldassarre, Resmini, Giuseppina, Rubinacci, Alessandro, Russo, Enzo, Scillitani, Alfredo, Silveri, Ferdinando, Leali, Paolo Tranquilli, Trotta, Francesco, Ulivieri, Massimo, Verdoia, Cesare, Versace, Francesco, and Vinicola, Vincenzo

Subjects
Spinal fracture, Fracture, Rheumatology, Observational study, Osteoporosis therapy, Teriparatide, Immunology, Osteoporosi, Immunology and Allergy, Parathyroid hormone, Spine
Abstract

Objective To estimate the proportion of patients with very severe osteoporosis (those covered by the reimbursement criteria of the Italian National Health Service) experiencing new vertebral and non-vertebral fragility fractures in the first 24 months of a new anti-osteoporosis treatment. Methods Prospective observational study in men and post-menopausal women (aged > 21 years) initiating anti-osteoporosis treatment for very severe osteoporosis. Eligibility was based on teriparatide (TPD) reimbursement criteria in Italy: Incident of vertebral or hip fracture during anti-resorptive treatment (minimum 1 year), or at least three prevalent severe vertebral fractures, or two prevalent severe vertebral fractures and a historical proximal hip fracture. Incidence of new clinical vertebral and non-vertebral fractures was documented by original x-rays and/or radiological reports, and a post-hoc analysis compared data from the TPD monotherapy population versus the total treated group. Results Overall, 767 patients (mean age 72.8 years, 90.7% women) were enrolled in the study, of whom 628, 538, 419 and 424 attended visits at 6, 12, 18 and 24 months, respectively. The most commonly prescribed therapy was TPD (single-agent; 64.5%), then bisphosphonates and other anti-resorptives (33.3%). A combination of different oral treatments was given to 22.5% of the patients. Overall treatment adherence at 24 months was 65.7%. In a post-hoc analysis, the overall incidence of new clinical vertebral and non-vertebral fractures in the total treated population was, respectively, 4.7% and 2.3% in the first 6 months; 1.8% and 1.6% in the 6-12 month period; 2.9% and 1.4% in the 12-18 month period; and 2.2% and 1.0% in the 18-24 month period. Conclusion In patients with very severe osteoporosis, the risk of new vertebral and non-vertebral fractures declined after the first 6 months and remained low throughout the study.

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