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The etiology, pathogenesis and risk for inheritance of congenital heart abnormalities are important questions. The development of fetal echocardiography and fetopathology helped in examination of this problem. Between September 1992 and June 1997 there were found four families where one member of the family had hypoplastic left heart syndrome and other member sustained fetal arrhythmia. The familiarity of hypoplastic left heart syndrome and some special forms of arrhythmias are well known. The reported familial association of these two abnormalities which in the first in the literature, may have a possibility that a sustained ectopic atrial arrhythmias are as severe risk factors for left heart abnormalities as other left heart abnormalities are.

To determine the accuracy of lung cancer mortality data based on clinical observations in the absence of autopsy and to identify factors affecting the accuracy of diagnosis.Admission, pre-autopsy and post-autopsy diagnoses were recorded for 1000 consecutive autopsies in each of two University departments in Budapest with high autopsy rates for persons dying in hospital. In those 87 cases where one or more diagnosis included primary lung cancer, additional data were collected concerning clinical investigations relevant to the diagnosis and the histological type lung cancer, and on smoking habits.59% (36/61) of lung cancers seen at autopsy were not detected pre-autopsy, while 50% (25/50) of those diagnosed pre-autopsy were not confirmed at autopsy. Many misdiagnoses arose because patients were too ill to be properly investigated and/or died before investigations could be completed. Accuracy of diagnosis increased with the number of diagnostic techniques applied, but was still far from perfect in the absence of necropsy. Underdiagnosis was commoner in non-smokers and overdiagnosis commoner in smokers.Without necropsy, lung cancer misdiagnosis is common, especially when modern diagnostic procedures cannot be fully employed. Knowledge of smoking habits may affect diagnostic accuracy.

Drawing on the papers in this volume that precede it, our discussion brings all the chapters of the long story of Alsónyék into a single narrative, discussing in more interpretive terms notions of persistent place, community, aggregation and coalescence, with an eye on different scales of analysis and the broader tempo of change. We look especially at the remarkably long persistence of Alsónyék, the intensity of its occupation and the trajectory of population increase and decline at the site. We begin by comparing general conditions of early village emergence with the specific evidence for the development of settlement and population in Transdanubia and beyond in central Europe, before summarising date estimates for the successive periods of occupation at Alsónyék itself, from Starčevo through LBK and Sopot to the Lengyel. We emphasise the long continuity of occupation except for the gap between Starčevo and LBK, the probable overlap between LBK and Sopot, and the acceleration of growth in the Lengyel period. The exceptional persistence of place seen at Alsónyék is examined in further detail, with comparison to elsewhere leading on to discussion of the sense of place and community that may have been experienced through the Alsónyék sequence. Characterisation of the Lengyel occupation as not only a major aggregation but also a coalescent community is explored; the causes of such developments elsewhere, as seen in the historical and ethnographic record, are noted, including periods of social instability and inter-community violence. The extraordinary intensity of activity at Alsónyék is further modelled in various ways to provide estimates of population and numbers of buildings in use through the Lengyel sequence. The peak of intense activity was probably only maintained for a generation or two around 4700 cal BC, and the decline of the Lengyel site was perhaps only slightly slower than its rise (covering two or three generations in the latter part of the 47th century cal BC). Activity did not reduce to its pre-Lengyel levels, however, but persisted for several more centuries at perhaps two or three times the intensity of any pre-Lengyel occupation. A search for the causes of the Alsónyék aggregation — and of its decline — remains challenging, though answers may eventually be found in the further study of the regional settlement complex or the detailed history of disease. No extensive signs of violence have so far been recorded. We further discuss possible constituents of the coalescence represented at Alsónyék, noting the frequent houses and possible households and neighbourhoods, and looking beyond these to the idea of wards, clans and moieties. Possible clues to internal differences within the site are noted for future research, and it is only with further work that the full Alsónyék story can be told., Bericht der Römisch-Germanischen Kommission, Bd. 94. 2013 (2016): Bericht der Römisch-Germanischen Kommission