Search

Your search keyword '"Martinez-Climent, Jose A."' showing total 6 results
Start Over Author "Martinez-Climent, Jose A." Language undetermined
6 results on '"Martinez-Climent, Jose A."'

1. Additional file 6: of Combined clinical and genomic signatures for the prognosis of early stage non-small cell lung cancer based on gene copy number alterations

Author

Aramburu, Ander, Zudaire, Isabel, Pajares, María, Agorreta, Jackeline, Orta, Alberto, Lozano, María, Gúrpide, Alfonso, Gómez-Román, Javier, Martinez-Climent, Jose, Jassem, Jacek, Skrzypski, Marcin, Milind Suraokar, Behrens, Carmen, Wistuba, Ignacio, Pio, Ruben, Rubio, Angel, and Montuenga, Luis

Abstract

Kaplan Meier curves for the validation set of ADC (Figure S9) and SCC (Figure S10) using the genomic model (A) and the clinical-genomic model (B) highlighted in red. Patients were divided into two risk groups according to the predicted risk. Survival curves were compared using the log-rank test p-values. (PPTX 6554 kb)

Published
2015
Full Text
View/download PDF

2. Additional file 1: of Combined clinical and genomic signatures for the prognosis of early stage non-small cell lung cancer based on gene copy number alterations

Author

Aramburu, Ander, Zudaire, Isabel, Pajares, María, Agorreta, Jackeline, Orta, Alberto, Lozano, María, Gúrpide, Alfonso, Gómez-Román, Javier, Martinez-Climent, Jose, Jassem, Jacek, Skrzypski, Marcin, Milind Suraokar, Behrens, Carmen, Wistuba, Ignacio, Pio, Ruben, Rubio, Angel, and Montuenga, Luis

Subjects
3. Good health
Abstract

Supplementary Methods, Results, Figure Legends & Tables. (DOCX 94 kb)

3. Additional file 1: of Combined clinical and genomic signatures for the prognosis of early stage non-small cell lung cancer based on gene copy number alterations

Author

Aramburu, Ander, Zudaire, Isabel, Pajares, María, Agorreta, Jackeline, Orta, Alberto, Lozano, María, Gúrpide, Alfonso, Gómez-Román, Javier, Martinez-Climent, Jose, Jassem, Jacek, Skrzypski, Marcin, Milind Suraokar, Behrens, Carmen, Wistuba, Ignacio, Pio, Ruben, Rubio, Angel, and Montuenga, Luis

Subjects
3. Good health
Abstract

Supplementary Methods, Results, Figure Legends & Tables. (DOCX 94 kb)

6. Preneoplastic somatic mutations including MYD88(L265P) in lymphoplasmacytic lymphoma

Author

Sara Rodriguez, Jon Celay, Ibai Goicoechea, Cristina Jimenez, Cirino Botta, Maria-José Garcia-Barchino, Juan-Jose Garces, Marta Larrayoz, Susana Santos, Diego Alignani, Amaia Vilas-Zornoza, Cristina Perez, Sonia Garate, Sarai Sarvide, Aitziber Lopez, Hans-Christian Reinhardt, Yolanda R. Carrasco, Isidro Sanchez-Garcia, Maria-Jose Larrayoz, Maria-Jose Calasanz, Carlos Panizo, Felipe Prosper, Jose-Maria Lamo-Espinosa, Marina Motta, Alessandra Tucci, Antonio Sacco, Massimo Gentile, Sara Duarte, Helena Vitoria, Catarina Geraldes, Artur Paiva, Noemi Puig, Ramon Garcia-Sanz, Aldo M. Roccaro, Gema Fuerte, Jesus F. San Miguel, Jose-Angel Martinez-Climent, Bruno Paiva, Rodriguez, Sara, Celay, Jon, Goicoechea, Ibai, Jimenez, Cristina, Botta, Cirino, Garcia-Barchino, Maria-José, Garces, Juan-Jose, Larrayoz, Marta, Santos, Susana, Alignani, Diego, Vilas-Zornoza, Amaia, Perez, Cristina, Garate, Sonia, Sarvide, Sarai, Lopez, Aitziber, Reinhardt, Hans-Christian, Carrasco, Yolanda R, Sanchez-Garcia, Isidro, Larrayoz, Maria-Jose, Calasanz, Maria-Jose, Panizo, Carlo, Prosper, Felipe, Lamo-Espinosa, Jose-Maria, Motta, Marina, Tucci, Alessandra, Sacco, Antonio, Gentile, Massimo, Duarte, Sara, Vitoria, Helena, Geraldes, Catarina, Paiva, Artur, Puig, Noemi, Garcia-Sanz, Ramon, Roccaro, Aldo M, Fuerte, Gema, San Miguel, Jesus F, Martinez-Climent, Jose-Angel, and Paiva, Bruno

Subjects
Multidisciplinary, hemic and lymphatic diseases, Lymphoplasmacytic lymphoma, lymphoplasmacytic lymphoma, MYD88, Mutations, B cell lymphoma, single cell
Abstract

Normal cell counterparts of solid and myeloid tumors accumulate mutations years before disease onset; whether this occurs in B lymphocytes before lymphoma remains uncertain. We sequenced multiple stages of the B lineage in elderly individuals and patients with lymphoplasmacytic lymphoma, a singular disease for studying lymphomagenesis because of the high prevalence of mutated MYD88 . We observed similar accumulation of random mutations in B lineages from both cohorts and unexpectedly found MYD88 L265P in normal precursor and mature B lymphocytes from patients with lymphoma. We uncovered genetic and transcriptional pathways driving malignant transformation and leveraged these to model lymphoplasmacytic lymphoma in mice, based on mutated MYD88 in B cell precursors and BCL2 overexpression. Thus, MYD88 L265P is a preneoplastic event, which challenges the current understanding of lymphomagenesis and may have implications for early detection of B cell lymphomas.

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results