Search

Your search keyword '"Marco"' showing total 374,720 results
Start Over Author "Marco" Language undetermined
374,720 results on '"Marco"'

2. Renal Stem Cells, Renal Resistive Index, and Neutrophil Gelatinase Associated Lipocalin Changes After Revascularization in Patients With Renovascular Hypertension and Ischemic Nephropathy

Author

Mariadelina Simeoni, Rosario Cianci, Antonietta Gigante, Adolfo Marco Perrotta, Sonia Ronchey, Nicola Mangialardi, Annalisa Schioppa, Oriana De Marco, Eleonora Cianci, Cristiana Barbati, Silvia Lai, Claudio Ferri, Cianci, Rosario, Simeoni, Mariadelina, Gigante, Antonietta, Marco Perrotta, Adolfo, Ronchey, Sonia, Mangialardi, Nicola, Schioppa, Annalisa, De Marco, Oriana, Cianci, Eleonora, Barbati, Cristiana, Lai, Silvia, and Ferri, Claudio

Subjects
Pharmacology, Renal staminal cell, Drug Discovery, Percutaneous transluminal renal angioplasty, Renal resistive index, Ischemic nephropathy, Renal artery stenosi, NGAL, Vascular stenting
Abstract

Background: Percutaneous transluminal renal angioplasty (PTRA) with or without stenting is the gold standard therapy in patients with atherosclerotic renal artery stenosis (aRAS). However, therapeutic success depends on the correct timing of revascularization and the reversibility of the renal damage. Materials and Methods: We report a case series of patients treated with PTRA for renovascular hypertension and ischemic nephropathy. We measured bilateral renal resistive index (RRI), circulating renal stem cells (RSC), and Neutrophil Gelatinase Associated Lipocalin (NGAL) at baseline and after PTRA at different time points to understand their changes in post-revascularization. Results: At baseline, the studied patients (n = 5) had different RSC levels. After PTRAs, all patients showed an improvement in blood pressure, while renal function varied differently within the studied subjects. RRI > 0.75 at baseline and the absence of NGAL decrease after PTRAs were associated with post-PTRA renal function worsening, despite an increase of RSC in all patients. Conclusions: Although limited to a few patients, our observation allowed the exploration of the behaviour of the studied parameters in different degrees of renal ischemia. This revealed different disease models suggesting the importance of further investigations in larger and homogeneous cohorts to confirm that a greater basal RSC percentage, low RRI values before PTRA, and a post-revascularization NGAL reduction could be related to better renal outcomes in aRAS patients.

Published
2023
Full Text
View/download PDF

3. Treatments for intracranial hypertension in acute brain-injured patients: grading, timing, and association with outcome. Data from the SYNAPSE-ICU study

Author

Robba, Chiara, Graziano, Francesca, Guglielmi, Angelo, Rebora, Paola, Galimberti, Stefania, Taccone, Fabio S, Citerio, Giuseppe, Walter Videtta, Gustavo Domeniconi, María Estrella Giménez, Mariela Fumale, Edgar Daniel Amundarain, Matias Casanova, Michael Reade, Elizabeth Hallt, David Pearson, Ian Seppelt, Raimund Helbok, Valery Davidovich, Geert Meyfroidt, Ilaria Alice Crippa, Liese Mebis, Patrick Biston, Stijn Van De Velde, Glorieux Denis, Pedro Kurtz, Samia Yasin Wayhs, Mypinder Sekhon, Donald Griesdale, Andrea Rigamonti, José Miguel Montes, Rodrigo Pérez-Araos, Jorge H Mejia-Mantilla, Andrés Gempeler, Ray Mendoza, Natasa Kovac, Hedgar Berty Gutiérrez, Vera Spatenkova, Marek Fencl, Roman Gal, Ondrej Hrdy, Kamil Vrbica, Josef Skola, Eva Provaznikova, Jakub Kletecka, Pavel Lavicka, Piergiorgio Bresil, Marianne Levin, Josefine Thomsen, Thomas Egmose Larsen, Henrik Westy Hoffmeyer, Morten Olskjaer Holm, Jesper Borg Andersen, Birgitte Majholm, Margit Smitt, Heidi Shil Eddelien, Manuel Jibaja, Freddy Maldonado, María Fernanda García, Karim Asehnoune, Bertrand Pons, Gérard Audibert, Manon Lucca, Guillaume Besch, Pierluigi Banco, Raphael Cinotti, Hervé Q Uintard, Benjamin Soyer, Anais Caillard, Clement Gakuba, Romain Sonneville, Stefan Wolf, Kristina Fuest, Lea Albrecht, Sarah Grotheer, Sandro M Krieg, Stefan J Schaller, Charikleia Vrettou, Eftychia Kontoudaki, Anna Efthymiou, Elena Palli, Demosthenes Makris, Chrysi Diakaki, Christina Iasonidou, Aikaterini Dimoula, Georgios Koukoulitsios, George Kyriazopoulos, Nikolas Pantelas, Syragoula Tsikriki, Electra Eleni Stamou, Achileas Giannopoulos, Eleni Mouloudi, Ping Shum Hoi, Yan Chan Cheuk, Hewa Kandamby Darshana, Krisztián Tánczos, Gabor Nardai, Zoltan Szentkereszty, Harsh Sapra, Deepak Gupta, Kaveri Sharma, Saurabh Anand, Ankur Luthra, Summit Bloria, Rajeev Chauhan, Nidhi Panda, Ahmad Ozair, Bram Kilapong, Anass Alsudani, Giuseppe Citerio, Alessandra Soragni, Alessandro Motta, Andrea Marudi, Elisabetta Bertellini, Anselmo Caricato, Camilla Gelormini, Eleonora Ioannoni, Eleonora Stival, Serena Silva, Federico Pozzi, Iole Brunetti, Andrea Cortegiani, Edoardo Picetti, Federico Villa, Italo Calamai, Maria Chiara Casadio, Maria Concetta Quartarone, Marzia Grandis, Federico Magni, Silvia Del Bianco, Claudia Bonetti, Virginia Buldini, Aimone Giugni, Simone Maria Zerbi, Marco Carbonara, Antonella Cotoia, Antonio Izzi, Olegs Sabelnikovs, Muhammed Elhadi, Hazem Ahmed, Silvio A Ñamendys Silva, Gilberto Adrian Gasca López, Gentle S Shrestha, Shirish Maskey, Tamanna Bajracharya, Khadka Nilam, Prakash Kafle, Laleet Rajbanshi, Yam Bahadur Roka, Olufemi Idowu, Khan Muhammad Mukhtar, Juan Luis Pinedo Portilla, Klaudyna Kojder, Irene Aragao, Ricardo Freitas, Marco Simoes, Dario Batista, Cecília Pacheco, Fátima Assunção, Luís Lencastre, Pedro Cavaleiro, Mohamed Abdelaty, Alex Gritsan, Sergey Khomiakov Sergey, Dovbysh Nikolay, Yaseen Arabi, Primoz Gradisek, Petra Forjan, Mara Škoti, Suada Filekovic Ribaric, Nataša Milivojevic, Sergeja Kozar, Rafael Badenes, Aaron Blandino Ortiz, Mikel Celaya Lopez, Laura Galarza, Luisa Corral, Africa Lores, Ricard Soley, Laura Pariente, Pablo López Ojeda, Maria Dolores Arias Verdu, Luis Javier Yuste Dominguez, Maria Isabel Gonzalez Perez, Mireia Anglada, Patricia Duque, Ainhoa Serrano, Berta Monleon, Vanessa Blazquez, Mauro Oddo, Samia Abed Maillard, Paola Morelli, John-Paul Miroz, Eva Favre, Walid Sellami, Massimo Lamperti, Jamil Dibu, Richard Sivities, Angelos Kolias, Chris Thompson, Christopher Hawthorne, Justin Roberts, Lara Prisco, Roger Lightfoot, Josè I Suarez, Luci Rivera-Lara, Susanne Muehlschlegel, Juan Padilla, Sanjeev Sivakumar, Daiwai Olson, Robba, C, Graziano, F, Guglielmi, A, Rebora, P, Galimberti, S, Taccone, F, Citerio, G, Robba, Chiara, Graziano, Francesca, Guglielmi, Angelo, Rebora, Paola, Galimberti, Stefania, Taccone, Fabio S, Citerio, Giuseppe, and Walter Videtta, Gustavo Domeniconi, María Estrella Giménez, Mariela Fumale, Edgar Daniel Amundarain, Matias Casanova, Michael Reade, Elizabeth Hallt, David Pearson, Ian Seppelt, Raimund Helbok, Valery Davidovich, Geert Meyfroidt, Ilaria Alice Crippa, Liese Mebis, Patrick Biston, Stijn Van De Velde, Glorieux Denis, Pedro Kurtz, Samia Yasin Wayhs, Mypinder Sekhon, Donald Griesdale, Andrea Rigamonti, José Miguel Montes, Rodrigo Pérez-Araos, Jorge H Mejia-Mantilla, Andrés Gempeler, Ray Mendoza, Natasa Kovac, Hedgar Berty Gutiérrez, Vera Spatenkova, Marek Fencl, Roman Gal, Ondrej Hrdy, Kamil Vrbica, Josef Skola, Eva Provaznikova, Jakub Kletecka, Pavel Lavicka, Vera Spatenkova, Piergiorgio Bresil, Marianne Levin, Piergiorgio Bresil, Josefine Thomsen, Thomas Egmose Larsen, Henrik Westy Hoffmeyer, Morten Olskjaer Holm, Jesper Borg Andersen, Birgitte Majholm, Margit Smitt, Heidi Shil Eddelien, Manuel Jibaja, Freddy Maldonado, María Fernanda García, Karim Asehnoune, Bertrand Pons, Gérard Audibert, Manon Lucca, Guillaume Besch, Pierluigi Banco, Karim Asehnoune, Raphael Cinotti, Hervé Q Uintard, Benjamin Soyer, Anais Caillard, Clement Gakuba, Romain Sonneville, Stefan Wolf, Kristina Fuest, Lea Albrecht, Sarah Grotheer, Sandro M Krieg, Stefan J Schaller, Charikleia Vrettou, Eftychia Kontoudaki, Anna Efthymiou, Elena Palli, Demosthenes Makris, Chrysi Diakaki, Christina Iasonidou, Aikaterini Dimoula, Georgios Koukoulitsios, George Kyriazopoulos, Nikolas Pantelas, Syragoula Tsikriki, Electra Eleni Stamou, Charikleia Vrettou, Achileas Giannopoulos, Eleni Mouloudi, Ping Shum Hoi, Yan Chan Cheuk, Hewa Kandamby Darshana, Krisztián Tánczos, Gabor Nardai, Zoltan Szentkereszty, Harsh Sapra, Deepak Gupta, Kaveri Sharma, Saurabh Anand, Ankur Luthra, Summit Bloria, Rajeev Chauhan, Nidhi Panda, Ahmad Ozair, Bram Kilapong, Anass Alsudani, Giuseppe Citerio, Alessandra Soragni, Alessandro Motta, Andrea Marudi, Elisabetta Bertellini, Anselmo Caricato, Camilla Gelormini, Eleonora Ioannoni, Eleonora Stival, Serena Silva, Federico Pozzi, Iole Brunetti, Andrea Cortegiani, Edoardo Picetti, Federico Villa, Italo Calamai, Maria Chiara Casadio, Maria Concetta Quartarone, Marzia Grandis, Federico Magni, Silvia Del Bianco, Claudia Bonetti, Virginia Buldini, Aimone Giugni, Simone Maria Zerbi, Marco Carbonara, Antonella Cotoia, Antonio Izzi, Olegs Sabelnikovs, Muhammed Elhadi, Hazem Ahmed, Silvio A Ñamendys Silva, Gilberto Adrian Gasca López, Gentle S Shrestha, Shirish Maskey, Tamanna Bajracharya, Khadka Nilam, Prakash Kafle, Laleet Rajbanshi, Yam Bahadur Roka, Olufemi Idowu, Khan Muhammad Mukhtar, Juan Luis Pinedo Portilla, Klaudyna Kojder, Irene Aragao, Ricardo Freitas, Marco Simoes, Dario Batista, Cecília Pacheco, Fátima Assunção, Luís Lencastre, Pedro Cavaleiro, Mohamed Abdelaty, Alex Gritsan, Sergey Khomiakov Sergey, Dovbysh Nikolay, Yaseen Arabi, Primoz Gradisek, Petra Forjan, Mara Škoti, Suada Filekovic Ribaric, Primoz Gradisek, Nataša Milivojevic, Sergeja Kozar, Rafael Badenes, Aaron Blandino Ortiz, Mikel Celaya Lopez, Laura Galarza, Luisa Corral, Africa Lores, Ricard Soley, Laura Pariente, Pablo López Ojeda, Maria Dolores Arias Verdu, Luis Javier Yuste Dominguez, Maria Isabel Gonzalez Perez, Mireia Anglada, Patricia Duque, Ainhoa Serrano, Berta Monleon, Vanessa Blazquez, Mauro Oddo, Samia Abed Maillard, Paola Morelli, John-Paul Miroz, Eva Favre, Walid Sellami, Massimo Lamperti, Jamil Dibu, Richard Sivities, Angelos Kolias, Chris Thompson, Christopher Hawthorne, Justin Roberts, Lara Prisco, Roger Lightfoot, Josè I Suarez, Luci Rivera-Lara, Susanne Muehlschlegel, Juan Padilla, Sanjeev Sivakumar, Daiwai Olson

Subjects
Subarachnoid haemorrhage, Traumatic brain injury, Intracranial pressure, Therapy intensity level, Critical Care and Intensive Care Medicine, Intracranial haemorrhage
Abstract

Purpose: Uncertainties remain about the safety and efficacy of therapies for managing intracranial hypertension in acute brain injured (ABI) patients. This study aims to describe the therapeutical approaches used in ABI, with/without intracranial pressure (ICP) monitoring, among different pathologies and across different countries, and their association with sixmonths mortality and neurological outcome. Methods: A preplanned subanalysis of the SYNAPSE-ICU study, a multicentre, prospective, international, observational cohort study, describing the ICP treatment, graded according to Therapy Intensity Level (TIL) scale, in patients with ABI during the first week of intensive care unit (ICU) admission. Results: 2320 patients were included in the analysis. The median age was 55 (I-III quartiles = 39-69) years, and 800 (34.5%) were female. During the first week from ICU admission, no-basic TIL was used in 382 (16.5%) patients, mild-moderate in 1643 (70.8%), and extreme in 295 cases (eTIL, 12.7%). Patients who received eTIL were younger (median age 49 (I-III quartiles = 35-62) vs 56 (40-69) years, p

Published
2023
Full Text
View/download PDF

5. Primary lymphoma of the medial cutaneous nerve of the forearm: the first case in a pure sensory nerve of the upper limb

Author

Rocco De Vitis, Marco D'Orio, Vincenzo Fiorentino, and Marco Passiatore

Subjects
Upper Extremity, Forearm, Lymphoma, Humans, Female, General Medicine, Sciatic Nerve, Skin
Abstract

Primary lymphoma of the peripheral nerve is very rare and occurs most frequently in sciatic nerves. We describe the first patient reported in literature with a primary lymphoma in a pure sensory peripheral nerve of the upper limb. A woman in her 40s, with painful swelling and dysaesthesias in her left forearm in the past 3 months, was presented at our unit. Clinical MRI and ultrasound findings revealed a lesion that showed signs of a peripheral nerve sheath tumour. After complete excision, morpho-pathological evaluation revealed a primary B-cell lymphoma. The patient underwent radiotherapy and at the last follow-up there were no signs of residual pathology. Peripheral neuropathy may be caused by a lymphoma involving the nerve. Hand surgeons have to distinguish primary lymphoma of the peripheral nerves from schwannoma for their different clinical behaviour.

Published
2024

6. Data Quality in Social Survey Research

Author

Marco Palmieri and Rosario Aprile

Abstract

Social survey researchers need to share criteria for assessing the quality of data. In the tradition of data quality debate, two antithetical positions emerge. One comes from the behaviourist paradigm: the quality of survey data is defined as the absence of distortions in the measurement process. The other was born within the pragmatic paradigm: data quality is the satisfaction of the logical and methodological conditions necessary to achieve the cognitive objectives of the research. The first position largely prevails, but the pragmatic one is more adequate because it looks at the actual research conditions that move the social survey research. This approach rejects the concept of true value; the data of survey research is constructed by the researcher's choices. This article explores the survey data quality in its pragmatic perspective, offering definitions of conceptual map, conversational interview, data fidelity, data quality, formal standardization, semantic standardization, social desirability, response accuracy, pretest, and validity.

Published
2024
Full Text
View/download PDF

7. Potential feasibility of atezolizumab-bevacizumab therapy in patients with hepatocellular carcinoma treated with tyrosine-kinase inhibitors

Author

Benedetta Stefanini, Laura Bucci, Valentina Santi, Nicola Reggidori, Davide Rampoldi, Lorenzo Lani, Alessandro Granito, Angelo Sangiovanni, Giuseppe Cabibbo, Fabio Farinati, Claudia Campani, Francesco Giuseppe Foschi, Gianluca Svegliati-Baroni, Giovanni Raimondo, Antonio Gasbarrini, Andrea Mega, Elisabetta Biasini, Rodolfo Sacco, Filomena Morisco, Eugenio Caturelli, Gianpaolo Vidili, Francesco Azzaroli, Edoardo G. Giannini, Gian Ludovico Rapaccini, Maurizia Rossana Brunetto, Alberto Masotto, Gerardo Nardone, Mariella Di Marco, Donatella Magalotti, Franco Trevisani, Maurizio Biselli, Paolo Caraceni, Annagiulia Gramenzi, Francesco Tovoli, Luca Muratori, Francesca Benevento, Gloria Allegrini, Calogero Cammà, Ciro Celsa, Paolo Giuffrida, Caterina Stornello, Mauro Grova, Carmelo Marco Giacchetto, Gabriele Rancatore, Maria Vittoria Grassini, Valentina Adotti, Stefano Gitto, Fabio Marra, Martina Rosi, Vittoria Bevilacqua, Alberto Borghi, Andrea Casadei Gardini, Fabio Conti, Anna Chiara Dall'Aglio, Giorgio Ercolani, Federica Mirici, Nicoletta de Matthaeis, Francesca Romana Ponziani, Gabriele Missale, Andrea Olivani, Maria Guarino, Valentina Cossiga, Mario Capasso, Ester Marina Cela, Antonio Facciorusso, Valentina Lauria, Giorgia Ghittoni, Giorgio Pelecca, Fabrizio Chegai, Fabio Coratella, Mariano Ortenzi, Serena Dell'Isola, Maria Stella Franzè, Carlo Saitta, Assunta Sauchella, Elton Dajti, Federico Ravaioli, Giulia Pieri, Maria Corina Plaz Torres, Filippo Oliveri, Gabriele Ricco, Veronica Romagnoli, Alessandro Inno, Fabiana Marchetti, Pietro Coccoli, Antonio Malerba, Alberta Cappelli, Rita Golfieri, Cristina Mosconi, null Matteo Renzulli, Stefanini, B., Bucci, L., Santi, V., Reggidori, N., Rampoldi, D., Lani, L., Granito, A., Sangiovanni, A., Cabibbo, G., Farinati, F., Campani, C., Foschi, F. G., Svegliati-Baroni, G., Raimondo, G., Gasbarrini, A., Mega, A., Biasini, E., Sacco, R., Morisco, F., Caturelli, E., Vidili, G., Azzaroli, F., Giannini, E. G., Rapaccini, G. L., Brunetto, M. R., Masotto, A., Nardone, G., Di Marco, M., Magalotti, D., Trevisani, F., Biselli, M., Caraceni, P., Gramenzi, A., Tovoli, F., Muratori, L., Benevento, F., Allegrini, G., Camma, C., Celsa, C., Giuffrida, P., Stornello, C., Grova, M., Giacchetto, C. M., Rancatore, G., Grassini, M. V., Adotti, V., Gitto, S., Marra, F., Rosi, M., Bevilacqua, V., Borghi, A., Gardini, A. C., Conti, F., Dall'Aglio, A. C., Ercolani, G., Mirici, F., de Matthaeis, N., Ponziani, F. R., Missale, G., Olivani, A., Guarino, M., Cossiga, V., Capasso, M., Cela, E. M., Facciorusso, A., Lauria, V., Ghittoni, G., Pelecca, G., Chegai, F., Coratella, F., Ortenzi, M., Dell'Isola, S., Franze, M. S., Saitta, C., Sauchella, A., Dajti, E., Ravaioli, F., Pieri, G., Torres, M. C. P., Oliveri, F., Ricco, G., Romagnoli, V., Inno, A., Marchetti, F., Coccoli, P., Malerba, A., Cappelli, A., Golfieri, R., Mosconi, C., Matteo, Renzulli, Stefanini, Benedetta, Bucci, Laura, Santi, Valentina, Reggidori, Nicola, Rampoldi, Davide, Lani, Lorenzo, Granito, Alessandro, Sangiovanni, Angelo, Cabibbo, Giuseppe, Farinati, Fabio, Campani, Claudia, Foschi, Francesco Giuseppe, Svegliati-Baroni, Gianluca, Raimondo, Giovanni, Gasbarrini, Antonio, Mega, Andrea, Biasini, Elisabetta, Sacco, Rodolfo, Morisco, Filomena, Caturelli, Eugenio, Vidili, Gianpaolo, Azzaroli, Francesco, Giannini, Edoardo G, Rapaccini, Gian Ludovico, Brunetto, Maurizia Rossana, Masotto, Alberto, Nardone, Gerardo, Di Marco, Mariella, Magalotti, Donatella, and Trevisani, Franco

Subjects
Atezolizumab-bevacizumab, Clinical Trials as Topic, Antineoplastic Combined Chemotherapy Protocol, Carcinoma, Hepatocellular, Systemic therapy, Hepatology, Hepatocellular carcinoma, Tirosin-kinase inhibitor, Liver Neoplasms, Gastroenterology, Bevacizumab, Feasibility Studie, Tyrosine, Human
Abstract

Background: The combination of atezolizumab-bevacizumab has been proven to be superior to sorafenib for the treatment of unresectable hepatocellular carcinoma not amenable to locoregional treatments, be-coming the standard of care of systemic therapy.Aim: This study aimed at assessing real-world feasibility of atezolizumab-bevacizumab in patients treated with tyrosine-kinase inhibitors.Methods: Among 1447 patients treated with tyrosine-kinase inhibitors from January 2010 to December 2020, we assessed the percentage of those potentially eligible to atezolizumab-bevacizumab (according to IMbrave-150 trial criteria), and the overall survival of eligible and non-eligible patients.Results: 422 (29%) patients were qualified for atezolizumab-bevacizumab therapy. The main exclusion causes were Child-Pugh class and Performance Status. Adopting the more permissive inclusion criteria of SHARP trial, 535 patients became eligible. The median overall survival of tyrosine-kinase inhibitors patients was 14.9 months, longer in eligible patients than in their counterpart due to better baseline liver function and oncological features.Conclusion: Real-world data indicate that less than one-third of hepatocellular carcinoma patients treated with tyrosine-kinase inhibitors are potentially eligible to atezolizumab-bevacizumab according to the reg-istration trial criteria. These patients have a longer survival than the non-eligible ones. If the selection criteria of atezolizumab-bevacizumab trial are maintained in clinical practice, tyrosine-kinase inhibitors will remain the most used systemic therapy for hepatocellular carcinoma patients.(c) 2022 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Published
2022
Full Text
View/download PDF

8. Changes in renal function after nephroureterectomy for upper urinary tract carcinoma: analysis of a large multicenter cohort (Radical Nephroureterectomy Outcomes (RaNeO) Research Consortium)

Author

Alessandro Tafuri, Michele Marchioni, Clara Cerrato, Andrea Mari, Riccardo Tellini, Katia Odorizzi, Alessandro Veccia, Daniele Amparore, Aliasger Shakir, Umberto Carbonara, Andrea Panunzio, Federica Trovato, Michele Catellani, Letizia M. I. Janello, Lorenzo Bianchi, Giacomo Novara, Fabrizio Dal Moro, Riccardo Schiavina, Elisa De Lorenzis, Paolo Parma, Sebastiano Cimino, Ottavio De Cobelli, Francesco Maiorino, Pierluigi Bove, Fabio Crocerossa, Francesco Cantiello, David D’Andrea, Federica Di Cosmo, Francesco Porpiglia, Pasquale Ditonno, Emanuele Montanari, Francesco Soria, Paolo Gontero, Giovanni Liguori, Carlo Trombetta, Guglielmo Mantica, Marco Borghesi, Carlo Terrone, Francesco Del Giudice, Alessandro Sciarra, Andrea Galosi, Marco Moschini, Shahrokh F. Shariat, Marta Di Nicola, Andrea Minervini, Matteo Ferro, Maria Angela Cerruto, Luigi Schips, Vincenzo Pagliarulo, Alessandro Antonelli, Tafuri, Alessandro, Marchioni, Michele, Cerrato, Clara, Mari, Andrea, Tellini, Riccardo, Odorizzi, Katia, Veccia, Alessandro, Amparore, Daniele, Shakir, Aliasger, Carbonara, Umberto, Panunzio, Andrea, Trovato, Federica, Catellani, Michele, Janello, Letizia M I, Bianchi, Lorenzo, Novara, Giacomo, Dal Moro, Fabrizio, Schiavina, Riccardo, De Lorenzis, Elisa, Parma, Paolo, Cimino, Sebastiano, De Cobelli, Ottavio, Maiorino, Francesco, Bove, Pierluigi, Crocerossa, Fabio, Cantiello, Francesco, D'Andrea, David, Di Cosmo, Federica, Porpiglia, Francesco, Ditonno, Pasquale, Montanari, Emanuele, Soria, Francesco, Gontero, Paolo, Liguori, Giovanni, Trombetta, Carlo, Mantica, Guglielmo, Borghesi, Marco, Terrone, Carlo, Del Giudice, Francesco, Sciarra, Alessandro, Galosi, Andrea, Moschini, Marco, Shariat, Shahrokh F, Di Nicola, Marta, Minervini, Andrea, Ferro, Matteo, Cerruto, Maria Angela, Schips, Luigi, Pagliarulo, Vincenzo, Antonelli, Alessandro, Tafuri A., Marchioni M., Cerrato C., Mari A., Tellini R., Odorizzi K., Veccia A., Amparore D., Shakir A., Carbonara U., Panunzio A., Trovato F., Catellani M., Janello L.M.I., Bianchi L., Novara G., Dal Moro F., Schiavina R., De Lorenzis E., Parma P., Cimino S., De Cobelli O., Maiorino F., Bove P., Crocerossa F., Cantiello F., D'Andrea D., Di Cosmo F., Porpiglia F., Ditonno P., Montanari E., Soria F., Gontero P., Liguori G., Trombetta C., Mantica G., Borghesi M., Terrone C., Del Giudice F., Sciarra A., Galosi A., Moschini M., Shariat S.F., Di Nicola M., Minervini A., Ferro M., Cerruto M.A., Schips L., Pagliarulo V., and Antonelli A.

Subjects
Male, Urologic Neoplasms, Acute Kidney Injury, Chronic Kidney Disease, Radical Nephroureterectomy, Upper tract urothelial carcinoma, Humans, Infant, Nephroureterectomy, Nephrectomy, Glomerular Filtration Rate, Retrospective Studies, Kidney, Carcinoma, Transitional Cell, Urinary Bladder Neoplasms, Urinary Tract, Ureteral Neoplasms, Urology, Retrospective Studie, Upper tract urothelial carcinoma, Radical Nephroureterectomy, Acute Kidney Injury, Chronic Kidney Disease, Carcinoma, Urologic Neoplasm, Urinary Bladder Neoplasm, Transitional Cell, Human
Abstract

Purpose To investigate prevalence and predictors of renal function variation in a multicenter cohort treated with radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). Methods Patients from 17 tertiary centers were included. Renal function variation was evaluated at postoperative day (POD)—1, 6 and 12 months. Timepoints differences were Δ1 = POD-1 eGFR − baseline eGFR; Δ2 = 6 months eGFR − POD-1 eGFR; Δ3 = 12 months eGFR − 6 months eGFR. We defined POD-1 acute kidney injury (AKI) as an increase in serum creatinine by ≥ 0.3 mg/dl or a 1.5 1.9-fold from baseline. Additionally, a cutoff of 60 ml/min in eGFR was considered to define renal function decline at 6 and 12 months. Logistic regression (LR) and linear mixed (LM) models were used to evaluate the association between clinical factors and eGFR decline and their interaction with follow-up. Results A total of 576 were included, of these 409(71.0%) and 403(70.0%) had an eGFR p p = 0.003), POD-1 AKI (OR 2.88, p p p p = 0.007), POD-1 AKI (OR 1.83, p = 0.02), and preoperative eGFR p p = 0.019), hydronephrosis (p p p = 0.001) influenced renal function variation (ß 9.2 ± 0.7, p Conclusion Age, preoperative eGFR and POD-1 AKI are independent predictors of 6 and 12 months renal function decline after RNU for UTUC.

Published
2022
Full Text
View/download PDF

9. Large-scale seismic damage scenario assessment of precast buildings after the May 2012 Emilia earthquake

Author

Lucia Praticò, Marco Bovo, Nicola Buratti, Marco Savoia, Lucia Praticò, Marco Bovo, Nicola Buratti, and Marco Savoia

Subjects
Scenario simulation, Geophysics, Precast building, Large-scale seismic assessment, Building and Construction, Geotechnical Engineering and Engineering Geology, Seismic vulnerability, Civil and Structural Engineering
Abstract

In May 2012, two strong earthquakes hit the northern Italy revealing the significant seismic vulnerability of precast reinforced concrete structures and causing severe damage and many collapses, and high economic losses. After the lesson learnt from these events, more reliable seismic design criteria have been established for the design of new structures and different approaches have been proposed for the seismic assessment of the existing structures. In this context, the paper presents the results of a first application of the PRESSAFE-disp method, recently proposed by the authors, allowing to define the fragility curves of precast RC buildings at various limit states, including collapse. A stock of 91 precast buildings in the industrial area of San Felice sul Panaro (Modena) was selected as a benchmark case study to verify the reliability of the method in assessing seismic damage scenarios. In particular, with reference to the 2012 seismic ground-motion, two large-scale stochastic models are outlined to predict the number of the buildings collapsed in the area. The first one is based on a Monte Carlo simulation which incorporates the evaluation of the uncertainties, while the second one is a direct simplified calculation. Comparative considerations on the outcomes of the two methods for different seismic intensities are discussed, including the directionality effect of the ground-motion. To test the soundness of the simulations, the results of the two methods are compared with the real data collected through in-situ surveys. The procedures proposed here result, on average, in good agreement with the observed damage scenario. It is worth noting that, due to the inherent simplicity of the methods, they could be implemented to perform scenario-based seismic loss assessments to estimate the financial consequences of an earthquake affecting one or more industrial areas, and to drive the decision-making process for the seismic retrofit of existing precast RC buildings.

Published
2022
Full Text
View/download PDF

10. Phylogeny of European Pyrochroa (Coleoptera, Pyrochroidae) reveals cryptic taxa and different glacial histories

Author

Marco Molfini, Emiliano Mancini, Marco A. Bologna, Molfini, Marco, Mancini, Emiliano, and Bologna, Marco A.

Subjects
phylogenetics, new species, glacial refugia, new species, phylogenetics, saproxylic beetles, taxonomy, Tenebrionoidea, taxonomy, glacial refugia, saproxylic beetles, Tenebrionoidea, Genetics, Animal Science and Zoology, Molecular Biology, Ecology, Evolution, Behavior and Systematics
Abstract

Only three saproxylic species of Pyrochroinae (Coleoptera: Pyrochroidae) are distributed in Europe, two of which belonging to Pyrochroa: P. coccinea and P. serraticornis. However, P. serraticornis is polytypic, for the presence of the endemic subspecies P. s. kiesenwetteri in southern Italy. Using both molecular and morphological data, we explored the phylogeny of the European Pyrochroa species. A multilocus (COI, CAD, 28S) phylogenetic analysis helped highlight different evolutionary histories for the two examined species. First, P. coccinea, distributed throughout Europe, showed a high differentiation among Italian and European populations. Furthermore, three different taxonomic entities were identified within P. serraticornis, among which the cryptic species Pyrochroa bifoveata sp. n. from central Europe is described and illustrated. A comprehensive identification key to the European Pyrochroinae is also provided. Our results also suggested an historical survival of P. coccinea and P. s. kiesenwetteri in glacial refugia in Italy, and a subsequent post-glacial spread of the former species throughout the Peninsula. In contrast, the current distribution of P. s. serraticornis likely originated from a post-glacial colonization of western European relict populations, while the survival of P. bifoveata plausibly occurred in more eastern glacial refugia (e.g. Carpathian or Balkan regions). Similarly, the European populations of P. coccinea could have originated from relict populations in glacial refugia out from the Italian Peninsula. More comprehensive data on the taxonomy, ecology and biogeography of Pyrochroa are needed to learn more about these species and to help preserve the European saproxylic fauna.

Published
2022
Full Text
View/download PDF

11. Structure, Composition and Morphology of Self-Assembled 2D Nanostructures Based on SnO2 Nanoparticles Observed in Unannealed Mn Doped Hydrated Form of Tin Oxide (II) or (IV) Synthesized by Co-precipitation Method

Author

Domingo Garcia-Gutierrez, Joaquin Reyes-Gonzalez, Diana Garcia-Gutierrez, and Marco Garza-Navarro

Subjects
Biomaterials, Materials Science (miscellaneous), Ceramics and Composites
Abstract

Background: 2D nanostructures are greatly interested in different technological applications, particularly optoelectronics. Tin oxide 2D nanostructures have shown great transparency and ideal charge carrier transport properties. Objective: The current study aims to evaluate the main characteristics of 2D-nanostructures observed during the synthesis of hydrated forms of tin oxide (II) or (IV) doped with Mn. Methods: A chemical co-precipitation method was used for the synthesis of the hydrated forms of tin oxide (II) or (IV) with different conditions on time (1 and 1.5 h) and temperature (60ºC and 90ºC), using MnCl2 as the manganese source. Results: X-ray diffraction and XPS results revealed the formation of the hydroromarchite phase (Sn6O4(OH)4) as the main product of the synthesis reaction. Scanning electron microscopy images were used to identify and measure, in a first approach, the 2D nanostructures observed as a result of the synthesis. Morphological characterization using different transmission electron microscopy techniques revealed the presence of nanoparticles that were observed to self-assemble to form the 2D nanostructures observed (nanorods and nanosheets). Nonetheless, selected-area electron diffraction suggested the presence of the cassiterite phase (SnO2) in the nanoparticles forming the 2D nanostructures. Furthermore, chemical analyses using energy-dispersive X-ray spectroscopy supported the observations made by the diffraction studies regarding the presence of cassiterite phase (SnO2) in the 2D nanostructures. The number of 2D nanostructures observed in the analyzed samples increased as the Mn concentration increased in the synthesis reaction. Conclusions: The addition of Mn as an intended doping element increased the crystallite size and the polycrystallinity of the synthesized hydrated forms of tin oxide (II) or (IV). Additionally, it also promoted the formation of 2D nanostructures made of SnO2 nanoparticles.

Published
2023
Full Text
View/download PDF

13. Characterization of Lateral Junctions and Micro-SQUIDs Involving Magnetic Multilayers

Author

Halima Giovanna Ahmad, Luigi Di Palma, Davide Massarotti, Marco Arzeo, Giovanni Piero Pepe, Francesco Tafuri, Oleg A. Mukhanov, Ivan P. Nevirkovets, Ahmad, Halima Giovanna, Di Palma, Luigi, Massarotti, Davide, Arzeo, Marco, Pepe, Giovanni Piero, Tafuri, Francesco, Mukhanov, Oleg A., and Nevirkovets, Ivan P.

Subjects
Junction, Magnetic field, Temperature measurement, Nonhomogeneous media, Josephson junction, Magnetic multilayer, Magnetic sensor, Electrical and Electronic Engineering, SQUID, Superconducting magnet, Condensed Matter Physics, Electronic, Optical and Magnetic Materials
Abstract

We have fabricated and characterized at low temperatures Nb/Ni/(Al/Ni)14/Nb lateral junctions and Nb micro-SQUIDs involving (Al/Py)10 multilayers (here Py is permalloy: 80% Ni − 20% Fe). We have studied - curves and Josephson critical current as a function of an external magnetic field Ic(H) at various temperatures and orientations of the applied magnetic field. These studies revealed that, for some orientations of the externally applied magnetic field, the Ic(H) dependence of the lateral junctions has a component highly sensitive to magnetic field. In addition, we have observed a SQUID-like Ic(H) dependence for devices, in which an orthogonally oriented (with respect to the substrate) Nb loop that includes two nanoscopic Josephson junctions is filled with a (Al/Py)10 multilayer. We believe the devices presented here are promising as magnetic field sensors on nanoscale for various applications where high spatial resolution is required

Published
2023
Full Text
View/download PDF

15. Regret affects the choice between neoadjuvant therapy and upfront surgery for potentially resectable pancreatic cancer

Author

Alessandro Cucchetti, Benjamin Djulbegovic, Stefano Crippa, Iztok Hozo, Monica Sbrancia, Athanasios Tsalatsanis, Cecilia Binda, Carlo Fabbri, Roberto Salvia, Massimo Falconi, Giorgio Ercolani, Sergio Alfieri, Arnaldo Amato, Marco Amisano, Andrea Anderloni, Antonio Maestri, Chiara Coluccio, Giovanni Brandi, Andrea Casadei-Gardini, Vincenzo Cennamo, Stefano Francesco Crinò, Raffaele Dalla Valle, Claudio De Angelis, Monica Di Battista, Massimo Di Maio, Mariacristina Di Marco, Marco Di Marco, Francesco Di Matteo, Roberto Di Mitri, Giuseppe Maria Ettorre, Antonio Facciorusso, Gabriella Farina, Giovanni Ferrari, Lorenzo Fornaro, Isabella Frigerio, Daniele Frisone, Lorenzo Fuccio, Andrea Gardini, Carlo Garufi, Riccardo Giampieri, Gian Luca Grazi, Elio Jovine, Emanuele Kauffmann, Serena Langella, Alberto Larghi, Mauro Manno, Emanuele Marciano, Marco Marzioni, Alberto Merighi, Massimiliano Mutignani, Bruno Nardo, Monica Niger, Valentina Palmisano, Stefano Partelli, Carmine Pinto, Enrico Piras, Ilario Giovanni Rapposelli, Michele Reni, Claudio Ricci, Lorenza Rimassa, Salvatore Siena, Cristiano Spada, Elisa Sperti, Mariangela Spezzaferro, Carlo Sposito, Stefano Tamberi, Roberto Troisi, Luigi Veneroni, Marco Vivarelli, and Alessandro Zerbi

Subjects
Surgery
Published
2023
Full Text
View/download PDF

17. The unhealthy lifestyle in primary biliary cholangitis: An enemy to fight

Author

Valentina Cossiga, Nora Cazzagon, Roberto Montalti, Stefania Ciminnisi, Maria Rosaria Attanasio, Francesco Pezzato, Marco Giacchetto, Maria Guarino, Vincenza Calvaruso, Annarosa Floreani, Filomena Morisco, Cossiga, Valentina, Cazzagon, Nora, Montalti, Roberto, Ciminnisi, Stefania, Attanasio, Maria Rosaria, Pezzato, Francesco, Giacchetto, Marco, Guarino, Maria, Calvaruso, Vincenza, Floreani, Annarosa, and Morisco, Filomena

Subjects
Eating habits, Lifestyle, Metabolic syndrome, Physical activity, Primary biliary cholangitis, Hepatology, Gastroenterology, Eating habit
Abstract

Background and aim: Metabolic dysfunctions, particularly hyperlipidemia, are a common finding in Primary Biliary Cholangitis (PBC). In presence of metabolic components of fatty-liver-disease (MAFLD), the liver fibrosis progression risk is higher. The aim of this study was to evaluate lifestyle of PBC patients compared to controls. Methods: In a prospective, multicenter study 107 PBC patients were enrolled; among these, 54 subjects were age-and sex-matched with 54 controls with a propensity-score-matching-analysis. Eating habits and physical activity were evaluated, respectively, with a food-frequency-questionnaire and with a short pre-validated-questionnaire. The adherence to Mediterranean diet was assessed with the alternate Mediterranean diet score. Results: The total fat intake was higher in controls than in PBC (p=0.004), unless above the national recommendations in both groups. Moreover, in PBC monounsaturated-fat and polyunsaturated-fatty-acid intakes and the adherence to Mediterranean diet were significantly lower than in controls (p

Published
2023
Full Text
View/download PDF

18. Mortality after transjugular intrahepatic portosystemic shunt in older adult patients with cirrhosis: A validated prediction model

Author

Francesco Vizzutti, Ciro Celsa, Vincenza Calvaruso, Marco Enea, Salvatore Battaglia, Laura Turco, Marco Senzolo, Silvia Nardelli, Roberto Miraglia, Davide Roccarina, Claudia Campani, Dario Saltini, Cristian Caporali, Federica Indulti, Stefano Gitto, Alberto Zanetto, Gabriele Di Maria, Marcello Bianchini, Maddalena Pecchini, Silvia Aspite, Chiara Di Bonaventura, Michele Citone, Tomas Guasconi, Fabrizio Di Benedetto, Umberto Arena, Fabrizio Fanelli, Luigi Maruzzelli, Oliviero Riggio, Patrizia Burra, Antonio Colecchia, Erica Villa, Fabio Marra, Calogero Cammà, Filippo Schepis, Vizzutti, Francesco, Celsa, Ciro, Calvaruso, Vincenza, Enea, Marco, Battaglia, Salvatore, Turco, Laura, Senzolo, Marco, Nardelli, Silvia, Miraglia, Roberto, Roccarina, Davide, Campani, Claudia, Saltini, Dario, Caporali, Cristian, Indulti, Federica, Gitto, Stefano, Zanetto, Alberto, Di Maria, Gabriele, Bianchini, Marcello, Pecchini, Maddalena, Aspite, Silvia, Di Bonaventura, Chiara, Citone, Michele, Guasconi, Toma, Di Benedetto, Fabrizio, Arena, Umberto, Fanelli, Fabrizio, Maruzzelli, Luigi, Riggio, Oliviero, Burra, Patrizia, Colecchia, Antonio, Villa, Erica, Marra, Fabio, Camma, Calogero, and Schepis, Filippo

Subjects
Hepatology, TIPS, elderly, cirrhosi
Abstract

Background and Aims Implantation of a transjugular intrahepatic portosystemic shunt (TIPS) improves survival in patients with cirrhosis with refractory ascites and portal hypertensive bleeding. However, the indication for TIPS in older adult patients (greater than or equal to 70 years) is debated, and a specific prediction model developed in this particular setting is lacking. The aim of this study was to develop and validate a multivariable model for an accurate prediction of mortality in older adults. Approach and Results We prospectively enrolled 411 consecutive patients observed at four referral centers with de novo TIPS implantation for refractory ascites or secondary prophylaxis of variceal bleeding (derivation cohort) and an external cohort of 415 patients with similar indications for TIPS (validation cohort). Older adult patients in the two cohorts were 99 and 76, respectively. A cause-specific Cox competing risks model was used to predict liver-related mortality, with orthotopic liver transplant and death for extrahepatic causes as competing events. Age, alcoholic etiology, creatinine levels, and international normalized ratio in the overall cohort, and creatinine and sodium levels in older adults were independent risk factors for liver-related death by multivariable analysis. Conclusions After TIPS implantation, mortality is increased by aging, but TIPS placement should not be precluded in patients older than 70 years. In older adults, creatinine and sodium levels are useful predictors for decision making. Further efforts to update the prediction model with larger sample size are warranted.

Published
2022
Full Text
View/download PDF

19. Return to sport after posterior spinal fusion for adolescent idiopathic scoliosis: what variables actually have an influence? A retrospective study

Author

Alberto Ruffilli, Francesca Barile, Giovanni Viroli, Marco Manzetti, Matteo Traversari, Marco Ialuna, Bartlomiej Dobromir Bulzacki Bogucki, Cesare Faldini, Ruffilli, Alberto, Barile, Francesca, Viroli, Giovanni, Manzetti, Marco, Traversari, Matteo, Ialuna, Marco, Bulzacki Bogucki, Bartlomiej Dobromir, and Faldini, Cesare

Subjects
Posterior spinal fusion, Lumbar Vertebrae, Adolescent, Thoracic Vertebrae, Follow-Up Studie, Return to Sport, Spinal Fusion, Treatment Outcome, Scoliosis, Adolescent idiopathic scoliosi, Retrospective Studie, Humans, Orthopedics and Sports Medicine, Scoliosi, Kyphosis, Sport, Human, Retrospective Studies, Follow-Up Studies
Abstract

Purpose To retrospectively evaluate a cohort of athletically active patients who underwent surgery for adolescent idiopathic scoliosis (AIS), and to determine which clinical, surgical and anthropometric variables influenced their return to sport after surgery. Methods 112 adolescents who underwent high-density posterior fusion for AIS by a single surgeon were analyzed for clinical, surgical and demographic predictors of return to presurgical physical activity levels. Data were retrospectively collected by charts and X-rays analysis and patients interviews. Results Preoperative main curve Cobb was 64.4 ± 14.12° and obtained correction was 70.0 ± 12.5%. Included patients played many different sports (Table 4), most of all ballet (44/112, 39.2%), swimming (40/112, 35.7%) and gymnastics (32/112, 28.6%). At an average of 50.3 months follow-up, 76 (67.8%) patients returned to sports (RTS) at an equal or higher level than preoperatively. Younger age, lower Lenke curve type and lower main curve Cobb were significantly associated with RTS. As for RTS timing, patients who returned within the first 6 months were younger, with a higher Lenke and a less severe main curve, a more distal UIV and a more proximal LIV. No complications related to RTS were registered. Conclusion In conclusion, patients with adolescent idiopathic scoliosis safely returned to physical activity after surgery. Younger age, higher Lenke type and lower main curve severity predicted a quicker return to sport. However, prospective studies are needed to confirm these findings.

Published
2022
Full Text
View/download PDF

20. Diagnostic Delay in Adolescents with Cancer During COVID-19 Pandemic: A New Price for Our Patients to Pay

Author

Andrea Pession, Paola Quarello, Marco Zecca, Maurizio Mascarin, Franca Fagioli, Marina Bertolotti, Teresa Perillo, Giuseppe Milano, Milena Maule, Assunta Tornesello, Andrea C. Ferrari, Marta Pierobon, Marco Spinelli, Quarello, Paola, Ferrari, Andrea, Mascarin, Maurizio, Milano, Giuseppe M, Tornesello, Assunta, Bertolotti, Marina, Spinelli, Marco, Pierobon, Marta, Perillo, Teresa, Maule, Milena, Zecca, Marco, Pession, Andrea, and Fagioli, Franca

Subjects
Pediatrics, medicine.medical_specialty, Delayed Diagnosis, Adolescent, Referral, Coronavirus disease 2019 (COVID-19), COVID-19, diagnostic delay, solid tumor, Disease, Neoplasms, Pandemic, medicine, Pediatric oncology, Humans, Young adult, Medical diagnosis, Child, Pandemics, Retrospective Studies, business.industry, Cancer, medicine.disease, Oncology, Communicable Disease Control, Pediatrics, Perinatology and Child Health, business
Abstract

Worldwide, the coronavirus 19 disease pandemic caused a worse chance of a timely diagnosis for cancer patients. We conducted a retrospective analysis of new diagnoses registered in the national pediatric oncology database, comparing the first lockdown period (March-May 2020) with the same period of 2015-2019. The total number of cases (0-19 years) dropped by 20.8% (from 441 between 2015 and 2019 to 349 in 2020). A major reduction was observed for adolescents (15-19 years) (-32.9%) and for adolescents with solid tumors (-56.4%, p = 0.03). Our data suggest that the enforced lockdown reduced the possibility for these already vulnerable patients to access the referral centers.

Published
2022
Full Text
View/download PDF

21. Prognostic impact of the updated 2018 <scp>HFA‐ESC</scp> definition of advanced heart failure: results from the <scp>HELP‐HF</scp> registry

Author

Matteo Pagnesi, Carlo Mario Lombardi, Mauro Chiarito, Davide Stolfo, Luca Baldetti, Ferdinando Loiacono, Chiara Tedino, Luca Arrigoni, Daniele Ghiraldin, Daniela Tomasoni, Riccardo Maria Inciardi, Marta Maccallini, Alessandro Villaschi, Gaia Gasparini, Marco Montella, Stefano Contessi, Daniele Cocianni, Maria Perotto, Giuseppe Barone, Marco Merlo, Alberto Maria Cappelletti, Gianfranco Sinagra, Daniela Pini, Marco Metra, Pagnesi, Matteo, Lombardi, Carlo Mario, Chiarito, Mauro, Stolfo, Davide, Baldetti, Luca, Loiacono, Ferdinando, Tedino, Chiara, Arrigoni, Luca, Ghiraldin, Daniele, Tomasoni, Daniela, Inciardi, Riccardo Maria, Maccallini, Marta, Villaschi, Alessandro, Gasparini, Gaia, Montella, Marco, Contessi, Stefano, Cocianni, Daniele, Perotto, Maria, Barone, Giuseppe, Merlo, Marco, Cappelletti, Alberto Maria, Sinagra, Gianfranco, Pini, Daniela, and Metra, Marco

Subjects
Aged, 80 and over, Male, Advanced heart failure, Heart Failure Association, Cardiology, Stroke Volume, Heart failure, Middle Aged, Prognosis, Ventricular Function, Left, European Society Of Cardiology, Hospitalization, Mortality, Humans, Female, Registries, Cardiology and Cardiovascular Medicine, Aged
Abstract

Aims The Heart Failure Association of the European Society of Cardiology (HFA-ESC) proposed a definition of advanced heart failure (HF) that has not been validated, yet. We assessed its prognostic impact in a consecutive series of patients with high-risk HF. Methods and results The HELP-HF registry enrolled consecutive patients with HF and at least one high-risk 'I NEED HELP' marker, evaluated at four Italian centres between 1(st) January 2020 and 30(th) November 2021. Patients meeting the HFA-ESC advanced HF definition were compared to patients not meeting this definition. The primary endpoint was the composite of all-cause mortality or first HF hospitalization. Out of 4753 patients with HF screened, 1149 (24.3%) patients with at least one high-risk 'I NEED HELP' marker were included (mean age 75.1 +/- 11.5 years, 67.3% male, median left ventricular ejection fraction [LVEF] 35% [interquartile range 25%-50%]). Among them, 193 (16.8%) patients met the HFA-ESC advanced HF definition. As compared to others, these patients were younger, had lower LVEF, higher natriuretic peptides and a worse clinical profile. The 1-year rate of the primary endpoint was 69.3% in patients with advanced HF according to the HFA-ESC definition versus 41.8% in the others (hazard ratio [HR] 2.23, 95% confidence interval [CI] 1.82-2.74, p < 0.001). The prognostic impact of the HFA-ESC advanced HF definition was confirmed after multivariable adjustment for relevant covariates (adjusted HR 1.98, 95% CI 1.57-2.50, p < 0.001). Conclusions The HFA-ESC advanced HF definition had a strong prognostic impact in a contemporary, real-world, multicentre high-risk cohort of patients with HF.

Published
2022
Full Text
View/download PDF

22. Introduction of the telemonitoring device Turbo+ in the management of patients suffering from asthma in Italy: a budget impact analysis

Author

Filippo Rumi, Michele Basile, Americo Cicchetti, Rosario Contiguglia, Antonella Pentassuglia, Alessandro Oliva, Gianenrico Senna, Marco Bonavia, Francesco Scarpelli, Marco Benvenuto, Rumi, Filippo, Basile, Michele, Cicchetti, Americo, Contiguglia, Rosario, Pentassuglia, Antonella, Oliva, Alessandro, Senna, Gianenrico, Bonavia, Marco, Scarpelli, Francesco, and Benvenuto, Marco

Subjects
Adherence, Asthma, Budget impact analysis, Economic evaluation, Telemedicine, Health Policy, health care economics and organizations
Abstract

Introduction: Adherence to long-term asthma control drugs is one of the key factors in improving disease management among patients with asthma. Poor adherence to long-term therapies significantly compromises the effectiveness of treatment and represents a problem in controlling the disease in terms of quality of life and economic impact. A budget impact analysis has been developed taking into account that Turbo+ technology (electronic monitoring device) can increase adherence to therapy in patients suffering from asthma. Methods: Coherently with the budget impact model methodology, we developed two different scenarios. One represents the clinical practice assuming a constant market share of 0,99% for Turbo+ and the other one assumes an incremental market share of Turbo+ over the time horizon considered. An increase in adherence to therapy will likely correspond to a reduction of exacerbations and a lower rate of hospitalizations, thus generating savings in terms of use of health resources. Results: The differential analysis shows an incremental saving in terms of resources absorbed by the National Health Service (NHS) over the time horizon considered. In the first year the savings are equal to € 795,658.64 and in the fifth year they are equal to € 3,520,636.34 for a total of resources saved in 5 years of € 10,882,028.50. Conclusions. The model shows how the diffusion of the Turbo+ programme can lead to savings in terms of health resources consumed by the NHS. Further analyses with new real-world data on adherence in asthmatic patients could be useful in confirming the results of the present analysis.

Published
2022
Full Text
View/download PDF

23. Prevalence and prognostic significance of ischemic late gadolinium enhancement pattern in non-ischemic dilated cardiomyopathy

Author

Giulia De Angelis, Antonio De Luca, Marco Merlo, Gaetano Nucifora, Maddalena Rossi, Davide Stolfo, Giulia Barbati, Annamaria De Bellis, Marco Masè, Pasquale Santangeli, Lorenzo Pagnan, Daniele Muser, Gianfranco Sinagra, De Angelis, Giulia, De Luca, Antonio, Merlo, Marco, Nucifora, Gaetano, Rossi, Maddalena, Stolfo, Davide, Barbati, Giulia, De Bellis, Annamaria, Masè, Marco, Santangeli, Pasquale, Pagnan, Lorenzo, Muser, Daniele, and Sinagra, Gianfranco

Subjects
Cardiomyopathy, Dilated, Cardiomyopathy, Prognosi, Contrast Media, Magnetic Resonance Imaging, Cine, Predictive Value of Test, Gadolinium, Prognosis, Magnetic Resonance Imaging, Cine, Retrospective Studie, Predictive Value of Tests, Dilated, Prevalence, Humans, Retrospective Studies, Cardiology and Cardiovascular Medicine, Human
Abstract

Background Typical late gadolinium enhancement (LGE) patterns in dilated cardiomyopathy (DCM) include intramyocardial and subepicardial distribution. However, the ischemic pattern of LGE (subendocardial and transmural) has also been reported in DCM without coronar y arter y disease (CAD), but its correlates and prognostic significance are still not known. On these bases, this study sought to describe the prevalence and prognostic significance of the ischemic LGE pattern in DCM. Methods A total of 611 DCM patients with available cardiac magnetic resonance were retrospectively analyzed. A composite of all-cause-death, major ventricular arrhythmias (MVAs), heart transplantation (HTx) or ventricular assist device (VAD) implantation was the primary outcome of the study. Secondary outcomes were a composite of sudden cardiac death or MVAs and a composite of death for refractory heart failure, HTx or VAD implantation. Results Ischemic LGE was found in 7% of DCM patients without significant CAD or history of myocardial infarction, most commonly inferior/inferolateral/anterolateral. Compared to patients with non-ischemic LGE, those with ischemic LGE had higher prevalence of hypertension and atrial fibrillation or flutter. Ischemic LGE was associated with worse long-term outcomes compared to non-ischemic LGE (36% vs 23% risk of primary outcome events at 5 years respectively, P = .006), and remained an independent predictor of primary outcome after adjustment for clinically and statistically significant variables (adjusted hazard ratio 2.059 [1.055-4.015], P = .034 with respect to non-ischemic LGE). Conclusions The ischemic pattern of LGE is not uncommon among DCM patients without CAD and is independently associated with worse long-term outcomes. (Am Heart J 2022;246:117-124.)

Published
2022
Full Text
View/download PDF

24. Intravenous Contrast Material for Cardiac Computed Tomography

Author

Ludovico La Grutta, Erica Maffei, Alberto Clemente, Giambattista Privitera, Marco Rengo, Sara Seitun, Roberto Malagò, Patrizia Toia, Manlio Acquafresca, Francesco Secchi, Matteo Gravina, Cesare Mantini, Arnaldo Scardapane, Roberto De Rosa, Luca Maria Carusi, Stefano Cossa, Fabio Falzea, Dante Chiappino, Andrea Annoni, Marco Francone, Ernesto Di Cesare, Massimo Midiri, Filippo Cademartiri, La Grutta, Ludovico, Maffei, Erica, Clemente, Alberto, Privitera, Giambattista, Rengo, Marco, Seitun, Sara, Malagò, Roberto, Toia, Patrizia, Acquafresca, Manlio, Secchi, Francesco, Gravina, Matteo, Mantini, Cesare, Scardapane, Arnaldo, De Rosa, Roberto, Carusi, Luca Maria, Cossa, Stefano, Falzea, Fabio, Chiappino, Dante, Annoni, Andrea, Francone, Marco, Di Cesare, Ernesto, Midiri, Massimo, and Cademartiri, Filippo

Subjects
safety, Pulmonary and Respiratory Medicine, Settore MED/36 - Diagnostica per Immagini e Radioterapia, coronary arterie, computed tomography angiography, contrast media, coronary arteries, image enhancement, Radiology, Nuclear Medicine and imaging, image enhancement, contrast media, safety, computed tomography angiographycoronary arteriesimage enhancementcontrast mediasafety
Abstract

Purpose: The Italian Registry of Contrast Material use in Cardiac Computed Tomography (iRCM-CCT) is a multicenter, multivendor, observational study on the use of contrast media (CM) in patients undergoing cardiac computed tomography (CCT). The aim of iRCM-CCT is to assess image quality and safety profile of intravenous CM compounds. Materials and methods: iRCM-CCT enrolled 1842 consecutive patients undergoing CCT (≥50 per site) at 20 cluster sites with the indication of suspected coronary artery disease. Demographic characteristics, CCT, and CM protocols, clinical indications, safety markers, radiation dose reports, qualitative (ie, poor vascular enhancement) and quantitative (ie, HU attenuation values) image parameters were recorded. A centralized coordinating center collected and assessed all image parameters. Results: The cohort included 891 men and 951 women (age: 63±14 y, body mass index: 26±4 kg/m2) studied with ≥64 detector rows computed tomography scanners and different iodinated intravenous CM protocols and compounds (iodixanol, iopamidol, iohexol, iobitridol, iopromide, and iomeprol). The following vascular attenuation was reported: 504±147 HU in the aorta, 451±146 HU in the right coronary artery, 474±146 HU in the left main, 451±146 HU in the left anterior descending artery, and 441±149 HU in the circumflex artery. In 4% of cases the image quality was not satisfactory due to poor enhancement. The following adverse reactions to CM were recorded: 6 (0.3%) extravasations and 17 (0.9%) reactions (11 mild, 4 moderate, 2 severe). Conclusions: In a multicenter registry on CM use during CCT the prevalence of CM-related adverse reactions was very low. The appropriate use of CM is a major determinant of image quality.

Published
2022
Full Text
View/download PDF

25. Exercise oxygen pulse kinetics in patients with hypertrophic cardiomyopathy

Author

Massimo Mapelli, Simona Romani, Damiano Magrì, Marco Merlo, Marco Cittar, Marco Masè, Manuela Muratori, Giovanna Gallo, Matteo Sclafani, Cosimo Carriere, Denise Zaffalon, Elisabetta Salvioni, Irene Mattavelli, Carlo Vignati, Fabiana De Martino, Sara Rovai, Camillo Autore, Gianfranco Sinagra, Piergiuseppe Agostoni, Mapelli, Massimo, Romani, Simona, Magrì, Damiano, Merlo, Marco, Cittar, Marco, Masè, Marco, Muratori, Manuela, Gallo, Giovanna, Sclafani, Matteo, Carriere, Cosimo, Zaffalon, Denise, Salvioni, Elisabetta, Mattavelli, Irene, Vignati, Carlo, De Martino, Fabiana, Rovai, Sara, Autore, Camillo, Sinagra, Gianfranco, and Agostoni, Piergiuseppe

Subjects
Adult, Male, Exercise Tolerance, Carbon Dioxide, Cardiomyopathy, Hypertrophic, Middle Aged, hypertrophic cardiomyopathy, Oxygen, Oxygen Consumption, Exercise Test, Humans, Female, Cardiology and Cardiovascular Medicine, Aged, Retrospective Studies
Abstract

ObjectivesReduced cardiac output (CO) has been considered crucial in symptoms’ genesis in hypertrophic cardiomyopathy (HCM). Absolute value and temporal behaviour of O2-pulse (oxygen uptake/heart rate (VO2/HR)), and the VO2/work relationship during exercise reflect closely stroke volume (SV) and CO changes, respectively. We hypothesise that adding O2-pulse absolute value and kinetics, and VO2/work relationship to standard cardiopulmonary exercise testing (CPET) could help identify more exercise-limited patients with HCM.MethodsCPETs were performed in 3 HCM dedicated clinical units. We retrospectively enrolled non-end-stage consecutive patients with HCM, grouped according to left ventricle outflow tract obstruction (LVOTO) at rest or during Valsalva manoeuvre (72% of patients with LVOTO 2-pulse and VO2, respectively, considering their absolute values and temporal behaviour during exercise.ResultsWe included 312 patients (70% males, age 49±18 years). Peak VO2(percentage of predicted), O2-pulse and ventilation to carbon dioxide production (VE/VCO2) slope did not change across LVOTO groups. Ninety-six (31%) patients with HCM presented an abnormal O2-pulse temporal behaviour, irrespective of LVOTO values. These patients showed lower peak systolic pressure, workload (106±45 vs 130±49 W), VO2(21.3±6.6 vs 24.1±7.7 mL/min/kg; 74%±17% vs 80%±20%) and O2-pulse (12 (9–14) vs 14 (11–17) mL/beat), with higher VE/VCO2slope (28 (25–31) vs 27 (24–31)) (p2/work slope.ConclusionNone of the frequently used CPET parameters, either as absolute values or dynamic relationships, were associated with LVOTO. Differently, an abnormal temporal behaviour of O2-pulse during exercise, which is strongly related to inadequate SV increase, correlates with reduced functional capacity (peak and anaerobic threshold VO2and workload) and increased VE/VCO2slope, identifying more advanced disease irrespectively of LVOTO.

Published
2022
Full Text
View/download PDF

26. Prediction of significant renal function decline after open, laparoscopic, and robotic partial nephrectomy: External validation of the Martini’s nomogram on the RECORD2 project cohort

Author

Alessandro Antonelli, Andrea Mari, Alessandro Tafuri, Riccardo Tellini, Umberto Capitanio, Paolo Gontero, Antonio Andrea Grosso, Vincenzo Li Marzi, Nicola Longo, Francesco Porpiglia, Angelo Porreca, Bernardo Rocco, Claudio Simeone, Riccardo Schiavina, Luigi Schips, Salvatore Siracusano, Carlo Terrone, Vincenzo Ficarra, Marco Carini, Andrea Minervini, Vincenzo Altieri, Daniele Amparore, Walter Artibani, Fabrizio Di Maida, Francesco Berardinelli, Pierluigi Bove, Carlo Andrea Bravi, Eugenio Brunocilla, Anna Cadenar, Antonio Celia, Elisabetta Costantini, Luigi Da Pozzo, Alberto Diminutto, Mario Falsaperla, Gaetano Grosso, Luca Lambertini, Alessandro Larcher, Francesco Maiorino, Giancarlo Marra, Francesco Montorsi, Andrea Polara, Riccardo Rizzetto, Marco Roscigno, Alchiede Simonato, Carlo Trombetta, Antonelli, Alessandro, Mari, Andrea, Tafuri, Alessandro, Tellini, Riccardo, Capitanio, Umberto, Gontero, Paolo, Andrea Grosso, Antonio, Li Marzi, Vincenzo, Longo, Nicola, Porpiglia, Francesco, Porreca, Angelo, Rocco, Bernardo, Simeone, Claudio, Schiavina, Riccardo, Schips, Luigi, Siracusano, Salvatore, Terrone, Carlo, Ficarra, Vincenzo, Carini, Marco, Minervini, Andrea, Berardinelli, Francesco, Bove, Pierluigi, Andrea Bravi, Carlo, Brunocilla, Eugenio, Cadenar, Anna, Celia, Antonio, Costantini, Elisabetta, Da Pozzo, Luigi, Diminutto, Alberto, Falsaperla, Mario, Grosso, Gaetano, Lambertini, Luca, Larcher, Alessandro, Maiorino, Francesco, Marra, Giancarlo, Montorsi, Francesco, Polara, Andrea, Rizzetto, Riccardo, Roscigno, Marco, Simonato, Alchiede, Trombetta, Carlo, and Alessandro Antonelli, Andrea Mari, Alessandro Tafuri, Riccardo Tellini, Umberto Capitanio, Paolo Gontero, Antonio Andrea Grosso, Vincenzo Li Marzi, Nicola Longo, Francesco Porpiglia, Angelo Porreca, Bernardo Rocco, Claudio Simeone, Riccardo Schiavina, Luigi Schips, Salvatore Siracusano, Carlo Terrone, Vincenzo Ficarra, Marco Carini, Andrea Minervini, Vincenzo Altieri, Daniele Amparore, Walter Artibani, Fabrizio Di Maida, Francesco Berardinelli, Pierluigi Bove, Carlo Andrea Bravi, Eugenio Brunocilla, Anna Cadenar, Antonio Celia, Elisabetta Costantini, Luigi Da Pozzo, Alberto Diminutto, Mario Falsaperla, Gaetano Grosso, Luca Lambertini, Alessandro Larcher, Francesco Maiorino, Giancarlo Marra, Francesco Montorsi, Andrea Polara, Riccardo Rizzetto, Marco Roscigno, Luigi Schips, Alchiede Simonato, Carlo Trombetta

Subjects
laparoscopy, nephron-sparing surgery, renal cell carcinoma, renal function, robotics, Humans, Kidney, Nephrectomy, Nomograms, Kidney Neoplasms, Laparoscopy, Robotic Surgical Procedures, Robotics, Urology
Abstract

Objectives: Martini et al. developed a nomogram to predict significant (>25%) renal function loss after robot-assisted partial nephrectomy and identified four risk categories. We aimed to externally validate Martini’s nomogram on a large, national, multi-institutional data set including open, laparoscopic, and robot-assisted partial nephrectomy. Methods: Data of 2584 patients treated with partial nephrectomy for renal masses at 26 urological Italian centers (RECORD2 project) were collected. Renal function was assessed at baseline, on third postoperative day, and then at 6, 12, 24, and 48 months postoperatively. Multivariable models accounting for variables included in the Martini’s nomogram were applied to each approach predicting renal function loss at all the specific timeframes. Results: Multivariable models showed high area under the curve for robot-assisted partial nephrectomy at 6- and 12-month (87.3% and 83.6%) and for laparoscopic partial nephrectomy (83.2% and 75.4%), whereas area under the curves were lower in open partial nephrectomy (78.4% and 75.2%). The predictive ability of the model decreased in all the surgical approaches at 48 months from surgery. Each Martini risk group showed an increasing percentage of patients developing a significant renal function reduction in the open, laparoscopic and robot-assisted partial nephrectomy group, as well as an increased probability to develop a significant estimated glomerular filtration rate reduction in the considered time cutoffs, although the predictive ability of the classes was

Published
2022
Full Text
View/download PDF

27. Association of country income level with the characteristics and outcomes of critically ill patients hospitalized with acute kidney injury and COVID-19

Author

Wainstein, Marina, Spyrison, Nicholas, Dai, Danyang, Ghadimi, Moji, Chavez-Iniquez, Jonathan Samuel, Rizo Topete, Lilia María, Citarella, Barbara Wanjiru, Merson, Laura, Pole, Jason, Claure-Del Granado, Rolando, Johnson, David W., Shrapnel, Sally, Abdukahil, heryl Ann, Abdulkadir, Nurul Najmee, Abe, Ryuzo, Abel, Laurent, Abrous, Amal, Absil, Lara, Acker, Andrew, Adachi, Shingo, Adrião, Diana, Al Ageel, Saleh, Ahmed, Shakeel, Ainscough, Kate, Airlangga, Eka, Aisa, Tharwat, Hssain, Ali Ait, Tamlihat, Younes Ait, Akimoto, Takako, Akmal, Ernita, Akwani, Chika, Al Qasim, Eman, Alalqam, Razi, Alberti, Angela, Al-dabbous, Tala, Alegesan, Senthilkumar, Alessi, Marta, Alex, Beatrice, Alexandre, Kévin, Al-Fares, Abdulrahman, Alfoudri, Huda, Ali, Imran, Alidjnou, Kazali Enagnon, Aliudin, Jeffrey, Alkhafajee, Qabas, Allavena, Clotilde, Allou, Nathalie, Alves, João, Alves, Rita, Alves, João Melo, Cabrita, Joana Alves, Amaral, Maria, Amira, Nur, Ampaw, Phoebe, Andini, Roberto, Andréjak, Claire, Angheben, Andrea, Angoulvant, François, Ansart, Séverine, Anthonidass, Sivanesen, Antonelli, Massimo, Antunes de Brito, Carlos Alexandre, Apriyana, Ardiyan, Arabi, Yaseen, Aragao, Irene, Arancibia, Francisco, Araujo, Carolline, Arcadipane, Antonio, Archambault, Patrick, Arenz, Lukas, Arlet, Jean-Benoît, Arnold-Day, Christel, Arora, Lovkesh, Arora, Rakesh, Artaud-Macari, Elise, Aryal, Diptesh, Asensio, Angel, Ashraf, Muhammad, Assie, Jean Baptiste, Asyraf, Amirul, Atif, Minahel, Atique, Anika, Auchabie, Johann, Aumaitre, Hugues, Auvet, Adrien, Azemar, Laurène, Azoulay, Cecile, Bach, Benjamin, Bachelet, Delphine, Badr, Claudine, Baillie, J. Kenneth, Baird, J Kevin, Bak, Erica, Bakakos, Agamemnon, Bakar, Nazreen Abu, Bal, Andriy, Balakrishnan, Mohanaprasanth, Balan, Valeria, Bani-Sadr, Firouzé, Barbalho, Renata, Barbosa, Nicholas Yuri, Barclay, Wendy S., Barnett, Saef Umar, Barnikel, Michaela, Barrelet, Audrey, Barrigoto, Cleide, Bartoli, Marie, Baruch, Joaquín, Basmaci, Romain, Hassin Basri, Muhammad Fadhli, Battaglini, Denise, Bauer, Jules, Bautista Rincon, Diego Fernando, Beane, Abigail, Bedossa, Alexandra, Bee, Ker Hong, Begum, Husna, Behilill, Sylvie, Beishuizen, Albertus, Beljantsev, Aleksandr, Bellemare, David, Beltrame, Anna, Beltrão, Beatriz Amorim, Beluze, Marine, Benech, Nicolas, Benjiman, Lionel Eric, Benkerrou, Dehbia, Bennett, Suzanne, Benny, Binny, Bento, Luís, Berdal, Jan-Erik, Bergeaud, Delphine, Bergin, Hazel, Bernal Sobrino, José Luis, Bertoli, Giulia, Bertolino, Lorenzo, Bessis, Simon, Bevilcaqua, Sybille, Bezulier, Karine, Bhatt, Amar, Bhavsar, Krishna, Bianco, Claudia, Bidin, Farah Nadiah, Singh, Moirangthem Bikram, Humaid, Felwa Bin, Bin Kamarudin, Mohd Nazlin, Bisoffi, Zeno, Bissuel, François, Biston, Patrick, Bitker, Laurent, Bitton, Jonathan, Blanco-Schweizer, Pablo, Blier, Catherine, Bloos, Frank, Blot, Mathieu, Blumberg, Lucille, Boccia, Filomena, Bodenes, Laetitia, Bogaert, Debby, Boivin, Anne-Hélène, Bolaños, Isabela, Bolze, Pierre-Adrien, Bompart, François, Borges, Diogo, Borie, Raphaël, Botelho-Nevers, Elisabeth, Bouadma, Lila, Bouchaud, Olivier, Bouchez, Sabelline, Bouhmani, Dounia, Bouhour, Damien, Bouiller, Kévin, Bouillet, Laurence, Bouisse, Camile, Boureau, Anne-Sophie, Bourke, John, Bouscambert, Maude, Bousquet, Aurore, Bouziotis, Jason, Boxma, Bianca, Boyer-Besseyre, Marielle, Boylan, Maria, Bozza, Fernando Augusto, Braconnier, Axelle, Braga, Cynthia, Monteiro, Filipa Brás, Brazzi, Luca, Breen, Patrick, Breen, Dorothy, Brewster, David, Brickell, Kathy, Browne, Shaunagh, Brusse-Keizer, Marjolein, Bryda, Petra, Buchtele, Nina, Bugaeva, Polina, Buisson, Marielle, Burhan, Erlina, Burrell, Aidan, Bustos, Ingrid G., Butnaru, Denis, Cabie, André, Cabral, Susana, Caceres, Eder, Cadoz, Cyril, Garcês, Rui Caetano, Calligy, Kate, Calvache, Jose Andres, Camões, João, Campana, Valentine, Campbell, Paul, Campisi, Josie, Cantero, Mireia, Caraux-Paz, Pauline, Cardellino, Chiara Simona, Cardoso, Sofia, Cardoso, Filipe, Cardoso, Filipa, Cardoso, Nelson, Carelli, Simone, Carlier, Nicolas, Carmoi, Thierry, Carney, Gayle, Carqueja, Inês, Carret, Marie-Christine, Carrier, François Martin, Carroll, Ida, Carson, Gail, Casanova, Maire-Laure, Cascão, Mariana, Casey, Siobhan, Casimiro, José, Cassandra, Bailey, Castanheira, Nidyanara, Castor-Alexandre, Guylaine, Castro, Ivo, Catarino, Ana, Catherine, François-Xavier, Cattaneo, Paolo, Cavalin, Roberta, Cavayas, Alexandros, Cervantes-Gonzalez, Minerva, Chair, Anissa, Chakveatze, Catherine, Chan, Adrienne, Chand, Meera, Chantalat Auger, Christelle, Chapplain, Jean-Marc, Charpentier, Charlotte, Chas, Julie, Chávez Iñiguez, Jonathan Samuel, Chen, Anjellica, Chen, Yih-Sharng, Chenard, Léo, Cheng, Matthew Pellan, Cheret, Antoine, Chiarabini, Thibault, Chica, Julian, Chidambaram, Suresh Kumar, Tho, Leong Chin, Chirouze, Catherine, Chiumello, Davide, Cho, Sung-Min, Cholley, Bernard, Chopin, Marie-Charlotte, Chow, Ting Soo, Chow, Yock Ping, Chua, Hiu Jian, Chua, Jonathan, Cidade, Jose Pedro, Ciullo, Anna, Clarke, Jennifer, Clohisey, Sara, Cobb, Perren J., Codan, Cassidy, Cody, Caitriona, Coelho, Alexandra, Coles, Megan, Coles, Jennifer, Colin, Gwenhaël, Collins, Michael, Colombo, Sebastiano Maria, Combs, Pamela, Connolly, Jennifer, Connor, Marie, Conrad, Anne, Conway, Elaine, Cooke, Graham S., Copland, Mary, Cordel, Hugues, Corley, Amanda, Cornelis, Sabine, Cornet, Alexander Daniel, Corpuz, Arianne Joy, Cortegiani, Andrea, Corvaisier, Grégory, Couffignal, Camille, Couffin-Cadiergues, Sandrine, Courtois, Roxane, Cousse, Stéphanie, Croonen, Sabine, Crowl, Gloria, Crump, Jonathan, Cruz, Claudina, Cruz Bermúdez, Juan Luis, Rojo, Jaime Cruz, Csete, Marc, Cullen, Ailbhe, Curley, Gerard, Curlier, Elodie, Curran, Colleen, Custodio, Paula, da Silva Filipe, Ana, Da Silveira, Charlene, Dabaliz, Al-Awwab, Dagens, Andrew, Dahly, Darren, Dalton, Heidi, Dalton, Jo, Daly, Seamus, Damas, Juliana, Daneman, Nick, Daniel, Corinne, Dankwa, Emmanuelle A., Dantas, Jorge, de Loughry, Gillian, De Montmollin, Etienne, Freitas de Oliveira França, Rafael, De Rosa, Rosanna, de Silva, Thushan, de Vries, Peter, Dean, David, Debard, Alexa, DeBenedictis, Bianca, Debray, Marie-Pierre, DeCastro, Nathalie, Dechert, William, Deconninck, Lauren, Decours, Romain, Defous, Eve, Delacroix, Isabelle, Delaveuve, Eric, Delavigne, Karen, Dell'Amore, Andrea, Delmas, Christelle, Delobel, Pierre, Delsing, Corine, Demonchy, Elisa, Denis, Emmanuelle, Deplanque, Dominique, Depuydt, Pieter, Desai, Mehul, Descamps, Diane, Desvallées, Mathilde, Dewayanti, Santi, Dhanger, Pathik, Diallo, Alpha, Diamantis, Sylvain, Da Silva, Fernanda Dias, Diaz, Juan Jose, Diaz, Rodrigo, Didier, Kévin, Diehl, Jean-Luc, Dieperink, Wim, Dimet, Jérôme, Dinot, Vincent, Diop, Fara, Diouf, Alphonsine, Dishon, Yael, Djossou, Félix, Docherty, Annemarie B., Doherty, Helen, Donnelly, Maria, Donnelly, Christl A., Donohue, Sean, Donohue, Yoann, Donohue, Chloe, Doran, Peter, Dorival, Céline, D'Ortenzio, Eric, Douglas, James Joshua, Dournon, Nathalie, Downer, Triona, Downey, Joanne, Downing, Mark, Drake, Tom, Driscoll, Aoife, Dryden, Murray, Fonseca, Claudio Duarte, Dubee, Vincent, Dubos, François, Ducancelle, Alexandre, Duculan, Toni, Dudman, Susanne, Duggal, Abhijit, Dunand, Paul, Dunning, Jake, Duplaix, Mathilde, Durante-Mangoni, Emanuele, Durham, Lucian, Dussol, Bertrand, Duthoit, Juliette, Duval, Xavier, Dyrhol-Riise, Anne Margarita, Ean, Sim Choon, Echeverria-Villalobos, Marco, Edwards, Eleanor, Egan, Siobhan, El Sanharawi, Mohammed, Elapavaluru, Subbarao, Elharrar, Brigitte, Eloy, Philippine, Elshazly, Tarek, Enderle, Isabelle, Endo, Tomoyuki, Eng, Chan Chee, Engelmann, Ilka, Enouf, Vincent, Epaulard, Olivier, Escher, Martina, Esperatti, Mariano, Esperou, Hélène, Santo, Catarina Espírito, Esposito-Farese, Marina, Estevão, João, Etienne, Manuel, Ettalhaoui, Nadia, Everding, Anna Greti, Evers, Mirjam, Fabre, Marc, Fabre, Isabelle, Faheem, Amna, Fahy, Arabella, Fairfield, Cameron J., Faria, Pedro, Fateena, Hanan, Fatoni, Arie Zainul, Faure, Karine, Favory, Raphaël, Fayed, Mohamed, Feely, Niamh, Feeney, Laura, Fernandes, Jorge, Fernandes, Marília Andreia, Fernandes, Susana, Ferrand, François-Xavier, Devouge, Eglantine Ferrand, Ferrão, Joana, Ferraz, Mário, Ferreira, Sílvia, Ferreira, Bernardo, Ferreira, Benigno, Ferriere, Nicolas, Ficko, Céline, Figueiredo-Mello, Claudia, Fiorda, Juan, Flament, Thomas, Flanagan, Emily, Flateau, Clara, Fletcher, Tom, Florence, Aline-Marie, Florio, Letizia Lucia, Flynn, Deirdre, Foley, Jean, Fomin, Victor, Fonseca, Tatiana, Forsyth, Simon, Foster, Denise, Foti, Giuseppe, Fourn, Erwan, Fowler, Robert A., Fraher, Marianne, Franch-Llasat, Diego, Fraser, John F., Fraser, Christophe, Freire, Marcela Vieira, Ribeiro, Ana Freitas, Friedrich, Caren, Fritz, Ricardo, Fry, Stéphanie, Fuentes, Nora, Fukuda, Masahiro, G, Argin, Gaborieau, Valérie, Gaci, Rostane, Gagliardi, Massimo, Gagnard, Jean-Charles, Gagneux-Brunon, Amandine, Gaião, Sérgio, Skeie, Linda Gail, Gallagher, Phil, Gamble, Carrol, Gani, Yasmin, Garan, Arthur, Garcia, Rebekha, Barrio, Noelia García, Garcia-Gallo, Esteban, Garot, Denis, Garrait, Valérie, Gault, Nathalie, Gavin, Aisling, Gavrylov, Anatoliy, Gaymard, Alexandre, Gebauer, Johannes, Geraud, Eva, Morlaes, Louis Gerbaud, Germano, Nuno, Ghosn, Jade, Giani, Marco, Gibson, Jess, Gigante, Tristan, Gilg, Morgane, Gilroy, Elaine, Giordano, Guillermo, Girvan, Michelle, Gissot, Valérie, Glikman, Daniel, Glybochko, Petr, Gnall, Eric, Goehringer, François, Goffard, Jean-Christophe, Goh, Jin Yi, Golob, Jonathan, Gominet, Marie, Gonzalez, Alicia, Gordon, Patricia, Gorenne, Isabelle, Gormley, Conor, Goubert, Laure, Goujard, Cécile, Goulenok, Tiphaine, Grable, Margarite, Grandin, Edward Wilson, Granier, Pascal, Grasselli, Giacomo, Green, Christopher A., Greenhalf, William, Greffe, Segolène, Grieco, Domenico Luca, Griffee, Matthew, Griffiths, Fiona, Grigoras, Ioana, Groenendijk, Albert, Gruner, Heidi, Gu, Yusing, Guedj, Jérémie, Guego, Martin, Guellec, Dewi, Guerreiro, Daniela, Guery, Romain, Guillaumot, Anne, Guilleminault, Laurent, Guimarães de Castro, Maisa, Guimard, Thomas, Haalboom, Marieke, Haber, Daniel, Habraken, Hannah, Hachemi, Ali, Hadri, Nadir, Hakak, Sheeba, Hall, Adam, Hall, Matthew, Halpin, Sophie, Hamer, Ansley, Hamers, Raph L., Hamidfar, Rebecca, Hammond, Terese, Hammond, Naomi, Han, Lim Yuen, Hao, Kok Wei, Hardwick, Hayley, Harrison, Ewen M., Harrison, Janet, Hartman, Alan, Hashmi, Junaid, Hayes, Ailbhe, Hays, Leanne, Heerman, Jan, Heggelund, Lars, Hendry, Ross, Hennessy, Martina, Hentzien, Maxime, Hernandez, Diana, Hershey, Andrew, Hesstvedt, Liv, Higgins, Eibhlin, Higgins, Dawn, Higgins, Rupert, Hinchion, Rita, Hinton, Samuel, Hiraiwa, Hiroaki, Hitoto, Hikombo, Ho, Antonia, Ho, Yi Bin, Hoctin, Alexandre, Hoffmann, Isabelle, Hoh, Wei Han, Hoiting, Oscar, Holt, Rebecca, Holter, Jan Cato, Horby, Peter, Hoshino, Kota, Houas, Ikram, Hough, Catherine L., Houltham, Stuart, Ming-Yang Hsu, Jimmy, Hulot, Jean-Sébastien, Hurd, Abby, Ijaz, Samreen, Ikram, M. Arfan, Illes, Hajnal-Gabriela, Imbert, Patrick, Inácio, Hugo, Ing, Yun Sii, Ippolito, Mariachiara, Isgett, Sarah, Isidoro, Tiago, Ismail, Nadiah, Isnard, Margaux, Itai, Junji, Ivulich, Daniel, Jaafar, Danielle, Jaafoura, Salma, Jabot, Julien, Jackson, Clare, Jaquet, Pierre, Jassat, Waasila, Jaud-Fischer, Coline, Jaureguiberry, Stéphane, Jego, Florence, Jelani, Anilawati Mat, Jenum, Synne, Joe, Ong Yiaw, Jorge García, Ruth N., Joseph, Mark, Joseph, Cédric, Jourdain, Mercé, Jouvet, Philippe, Jung, Anna, Juzar, Dafsah, Kafif, Ouifiya, Kaguelidou, Florentia, Kaisbain, Neerusha, Kaleesvran, Thavamany, Kali, Sabina, Kalomoiri, Smaragdi, Ayadi Kamaluddin, Muhammad Aisar, Che Kamaruddin, Zul Amali, Kamarudin, Nadiah, Kandamby, Darshana Hewa, Kandel, Chris, Kang, Kong Yeow, Karpayah, Pratap, Kartsonaki, Christiana, Kasugai, Daisuke, Kataria, Anant, Katz, Kevin, Kaur, Aasmine, Kay, Christy, Kayyali, Lamees, Keating, Seán, Kelly, Claire, Kelly, Yvelynne, Kelly, Andrea, Kelly, Niamh, Kelly, Aoife, Kelly, Sadie, Kelsey, Maeve, Kennedy, Ryan, Kennon, Kalynn, Kernan, Maeve, Kerroumi, Younes, Keshav, Sharma, Khalid, Imrana, Khalil, Antoine, Khan, Coralie, Khan, Irfan, Kho, Michelle E., Khoo, Saye, Khoo, Ryan, Khoo, Denisa, Kiat, Khor How, Kida, Yuri, Kiiza, Peter, Granerud, Beathe Kiland, Kildal, Anders Benjamin, Kim, Jae Burm, Kimmoun, Antoine, Kitamura, Nobuya, Klenerman, Paul, Klont, Rob, Bekken, Gry Kloumann, Knight, Stephen R., Komatsu, Mamoru, Korten, Volkan, Kpangon, Arsène, Krawczyk, Karolina, Krishnan, Sudhir, Krishnan, Vinothini, Kruglova, Oksana, Kumar, Deepali, Kumar, Ganesh, Tirupakuzhi Vijayaraghavan, Bharath Kumar, Vecham, Pavan Kumar, Kuriakose, Dinesh, Kurtzman, Ethan, Kutsogiannis, Demetrios, Kutsyna, Galyna, Kyriakoulis, Konstantinos, Lachatre, Marie, Lacoste, Marie, Laffey, John G., Lafhej, Nadhem, Lagrange, Marie, Laine, Fabrice, Lairez, Olivier, Lalueza, Antonio, Lambert, Marc, Langelot-Richard, Marie, Langlois, Vincent, Lantang, Eka Yudha, Lanza, Marina, Laouénan, Cédric, Laribi, Samira, Lariviere, Delphine, Lasry, Stéphane, Launay, Odile, Laureillard, Didier, Lavie-Badie, Yoan, Law, Andy, Lawrence, Teresa, Lawrence, Cassie, Le, Minh, Le Bihan, Clément, Le Bris, Cyril, Le Falher, Georges, Le Fevre, Lucie, Le Hingrat, Quentin, Le Maréchal, Marion, Le Mestre, Soizic, Le Moal, Gwenaël, Le Moing, Vincent, Le Nagard, Hervé, Le Turnier, Paul, Lee, Todd C., Lee, Su Hwan, Lee, James, Lee, Jennifer, Lee, Heng Gee, Lee, Biing Horng, Lee, Yi Lin, Leeming, Gary, Lefebvre, Laurent, Lefebvre, Bénédicte, Lefèvre, Benjamin, LeGac, Sylvie, Lelievre, Jean-Daniel, Lellouche, François, Lemaignen, Adrien, Lemee, Véronique, Lemeur, Anthony, Lemmink, Gretchen, Lene, Ha Sha, Leone, Michela, Leone, Marc, Lepiller, Quentin, Lescure, François-Xavier, Lesens, Olivier, Lesouhaitier, Mathieu, Lester-Grant, Amy, Letrou, Sophie, Levy, Yves, Levy, Bruno, Levy-Marchal, Claire, L'Her, Erwan, Bassi, Gianluigi Li, Liang, Janet, Liegeon, Geoffrey, Lim, Wei Shen, Lim, Kah Chuan, Lima, Chantre, Lina, Bruno, Lina, Lim, Lind, Andreas, Lingas, Guillaume, Lion-Daolio, Sylvie, Liu, Keibun, Livrozet, Marine, Lizotte, Patricia, Lolong, Navy, Loon, Leong Chee, Lopes, Diogo, Lopez-Colon, Dalia, Loschner, Anthony L., Loubet, Paul, Loufti, Bouchra, Louis, Guillame, Lourenco, Silvia, Low, Lee, Lowik, Marije, Loy, Jia Shyi, Lucet, Jean Christophe, Bermejo, Carlos Lumbreras, Luna, Carlos M., Lungu, Olguta, Lunn, Miles, Luong, Liem, Luque, Nestor, Luton, Dominique, Lyons, Ruth, Maasikas, Olavi, Mabiala, Oryane, Machado, Sara, Machado, Moïse, Macheda, Gabriel, Madiha, Hashmi, Maestro de la Calle, Guillermo, Mahieu, Rafael, Mahy, Sophie, Maier, Lars S., Maillet, Mylène, Maitre, Thomas, Malfertheiner, Maximilian, Malik, Nadia, Mallon, Paddy, Malvy, Denis, Manda, Victoria, Mandelbrot, Laurent, Manetta, Frank, Mankikian, Julie, Manning, Edmund, Manuel, Aldric, Sant`Ana Malaque, Ceila Maria, Marino, Flávio, Markowicz, Samuel, Marques, Ana, Marsh, Brian, Marsh, Laura, Marshal, Megan, Marshall, John, Martelli, Celina Turchi, Martin, Emily, Martin-Blondel, Guillaume, Martinez, F. Eduardo, Martin-Loeches, Ignacio, Martinot, Martin, Martins, João, Martins, Ana, Rego, Caroline Martins, Martucci, Gennaro, Martynenko, Olga, Marwali, Eva Miranda, Marzukie, Marsilla, Maslove, David, Mason, Sabina, Mat Nor, Mohd Basri, Matan, Moshe, Mathieu, Daniel, Mattei, Mathieu, Maulin, Laurence, Maxwell, Michael, Mazzoni, Thierry, Sweeney, Lisa Mc, McArthur, Colin, McCanny, Peter, McCarthy, Anne, McCarthy, Aine, McCloskey, Colin, McConnochie, Rachael, McDermott, Sherry, McDonald, Sarah E., McElroy, Aine, McElwee, Samuel, McEneany, Victoria, McEvoy, Natalie, McGeer, Allison, McKay, Chris, McKeown, Johnny, McLean, Kenneth A., McNicholas, Bairbre, McPartlan, Elaine, Meaney, Edel, Mear-Passard, Cécile, Mechlin, Maggie, Mehkri, Omar, Mele, Ferruccio, Menon, Kusum, Mentré, France, Mentzer, Alexander J., Mercier, Noémie, Mercier, Emmanuelle, Merckx, Antoine, Mergeay-Fabre, Mayka, Mergler, Blake, Mesquita, António, Metwally, Osama, Meybeck, Agnès, Meyer, Dan, Meynert, Alison M., Meysonnier, Vanina, Meziane, Amina, Mezidi, Mehdi, Michelanglei, Céline, Michelet, Isabelle, Mihelis, Efstathia, Mihnovit, Vladislav, Miller, Jennene, Misnan, Nor Arisah, Mohamed, Tahira Jamal, Eliza Mohamed, Nik Nur, Moin, Asma, Molinos, Elena, Molloy, Brenda, Monahan, Sinead, Mone, Mary, Monteiro, Agostinho, Montes, Claudia, Montrucchio, Giorgia, Moore, Shona C., Moore, Sarah, Cely, Lina Morales, Moro, Lucia, Motherway, Catherine, Motos, Ana, Mouquet, Hugo, Perrot, Clara Mouton, Moyet, Julien, Mudara, Caroline, Muh, Ng Yong, Muhamad, Dzawani, Mullaert, Jimmy, Müller, Fredrik, Müller, Karl Erik, Munblit, Daniel, Murphy, Aisling, Murphy, Lorna, Murray, Patrick, Murris, Marlène, Murthy, Srinivas, Musaab, Himed, Muyandy, Gugapriyaa, Myrodia, Dimitra Melia, Nagpal, Dave, Nagrebetsky, Alex, Narasimhan, Mangala, Narayanan, Nageswaran, Neant, Nadège, Necsoi, Coca, Nekliudov, Nikita, Neto, Raul, Neumann, Emily, Ng, Pauline Yeung, Ng, Wing Yiu, Nghi, Anthony, Nguyen, Duc, Choileain, Orna Ni, Leathlobhair, Niamh Ni, Nichol, Alistair D., Nitayavardhana, Prompak, Nonas, Stephanie, Mohd Noordin, Nurul Amani, Noret, Marion, Izzati Norharizam, Nurul Faten, Norman, Lisa, Notari, Alessandra, Noursadeghi, Mahdad, Nseir, Saad, Nusantara, Dwi Utomo, Nyamankolly, Elsa, Brien, Fionnuala O., Callaghan, Annmarie O., O'Callaghan, Annmarie, Occhipinti, Giovanna, OConnor, Derbrenn, Ogura, Takayuki, O'Halloran, Sophie, O'Hearn, Katie, Ohshimo, Shinichiro, Oliveira, João, Olliaro, Piero L., O'Neil, Conar, Ong, David S. Y., Ong, Jee Yan, Oosthuyzen, Wilna, Opavsky, Anne, Openshaw, Peter, Orozco-Chamorro, Claudia Milena, Ortoleva, Jamel, Osatnik, Javier, O'Shea, Linda, O'Sullivan, Miriam, Othman, Siti Zubaidah, Ouamara, Nadia, Ouissa, Rachida, Oziol, Eric, Pagadoy, Maïder, Pages, Justine, Palmarini, Massimo, Panarello, Giovanna, Panda, Prasan Kumar, Pang, Lai Hui, Panigada, Mauro, Pansu, Nathalie, Papadopoulos, Aurélie, Parke, Rachael, Pasquier, Jérémie, Pastene, Bruno, Patauner, Fabian, Pathmanathan, Mohan Dass, Patricio, Patricia, Patrier, Juliette, Patterson, Lisa, Paul, Mical, Paul, Christelle, Paulos, Jorge, Paxton, William A., Payen, Jean-François, Peake, Sandra L., Peariasamy, Kalaiarasu, Jiménez, Miguel Pedrera, Peek, Giles J., Peelman, Florent, Peiffer-Smadja, Nathan, Peigne, Vincent, Pejkovska, Mare, Pelosi, Paolo, Peltan, Ithan D., Pereira, Rui, Perez, Daniel, Periel, Luis, Perpoint, Thomas, Pesenti, Antonio, Pestre, Vincent, Petrou, Lenka, Petrovic, Michele, Petrov-Sanchez, Ventzislava, Pettersen, Frank Olav, Peytavin, Gilles, Pharand, Scott, Piagnerelli, Michael, Picard, Walter, Picone, Olivier, Pierobon, Carola, Piersma, Djura, Pimentel, Carlos, Piquard, Valentine, Pires, Catarina, Pironneau, Isabelle, Piroth, Lionel, Pitaloka, Ayodhia, Piubelli, Chiara, Pius, Riinu, Plantier, Laurent, Png, Hon Shen, Poissy, Julien, Pokeerbux, Ryadh, Poli, Sergio, Pollakis, Georgios, Ponscarme, Diane, Porto, Diego Bastos, Post, Andra-Maris, Postma, Douwe F., Povoa, Pedro, Póvoas, Diana, Powis, Jeff, Prapa, Sofia, Preau, Sébastien, Prebensen, Christian, Preiser, Jean-Charles, Prinssen, Anton, Proença, Lucia, Pudota, Sravya, Puéchal, Oriane, Semedi, Bambang Pujo, Purcell, Gregory, Quesada, Luisa, González, Víctor Quirós, Quist-Paulsen, Else, Quraishi, Mohammed, Qutishat, Fadi, Rabaud, Christian, Rafael, Aldo, Rafiq, Marie, Rahardjani, Mutia, Rahimi, Amir Kamel, Rahman, Rozanah Abd, Haji Ab Rahman, Ahmad Kashfi, Rainieri, Fernando, Rajahram, Giri Shan, Ramakrishnan, Nagarajan, Ramalho, José, Ramli, Ahmad Afiq, Rammaert, Blandine, Ramos, Grazielle Viana, Ranjan, Ritika, Rapp, Christophe, Rasmin, Menaldi, Rätsep, Indrek, Ravi, Tharmini, Real, Andre, Rebaudet, Stanislas, Redl, Sarah, Reeve, Brenda, Reid, Liadain, Reikvam, Dag Henrik, Reis, Renato, Remy, Martine, Ren, Hongru, Resseguier, Anne-Sophie, Revest, Matthieu, Rewa, Oleksa, Reyes, Tiago, Reyes, Luis Felipe, Ribeiro, Maria Ines, Richardson, David, Richardson, Denise, Richier, Laurent, Atikah Ahmad Ridzuan, Siti Nurul, Rios, Ana L., Rishu, Asgar, Rispal, Patrick, Risso, Karine, Rizer, Nicholas, Robba, Chiara, Roberto, André, Roberts, Stephanie, Robertson, David L., Robineau, Olivier, Roche-Campo, Ferran, Rodari, Paola, Rodeia, Simão, Roessler, Bernhard, Roger, Pierre-Marie, Rojek, Amanda, Romaru, Juliette, Roncon-Albuquerque, Roberto, Roriz, Mélanie, Rosa-Calatrava, Manuel, Rose, Michael, Rosenberger, Dorothea, Rossanese, Andrea, Rossetti, Matteo, Rossignol, Bénédicte, Rossignol, Patrick, Rousset, Stella, Roy, Carine, Roze, Benoît, Russell, Clark D., Ryan, Maria, Ryan, Maeve, Ryckaert, Steffi, Holten, Aleksander Rygh, Saba, Isabela, Sadat, Musharaf, Sahraei, Valla, Saint-Gilles, Maximilien, Sakiyalak, Pranya, Salazar, Leonardo, Sales, Gabriele, Sallaberry, Stéphane, Gandonniere, Charlotte Salmon, Salvator, Hélène, Sanchez, Emely, Sanchez, Olivier, Sanchez-Miralles, Angel, Sancho-Shimizu, Vanessa, Sandhu, Gyan, Sandhu, Zulfiqar, Sandrine, Pierre-François, Sandulescu, Oana, Santos, Marlene, Sarfo-Mensah, Shirley, Sarmiento, Iam Claire E., Sarton, Benjamine, Satyapriya, Sree, Satyawati, Rumaisah, Saviciute, Egle, Saw, Yen Tsen, Schaffer, Justin, Schermer, Tjard, Scherpereel, Arnaud, Schneider, Marion, Schroll, Stephan, Schwameis, Michael, Scott, Janet T., Scott-Brown, James, Sedillot, Nicholas, Seitz, Tamara, Selvarajoo, Mageswari, Semaille, Caroline, Semple, Malcolm G., Senian, Rasidah Bt, Senneville, Eric, Sepulveda, Claudia, Sequeira, Filipa, Sequeira, Tânia, Neto, Ary Serpa, Balazote, Pablo Serrano, Shadowitz, Ellen, Shahidan, Syamin Asyraf, Shamsah, Mohammad, Shankar, Anuraj, Sharjeel, Shaikh, Sharma, Pratima, Shaw, Catherine A., Shaw, Victoria, Sheenan, John Robert, Shi, Haixia, Shime, Nobuaki, Shimizu, Hiroaki, Shimizu, Keiki, Shum, Hoi Ping, Mohammed, Nassima Si, Siang, Ng Yong, Sibiude, Jeanne, Siddiqui, Atif, Sigfrid, Louise, Sillaots, Piret, Silva, Catarina, Silva, Rogério, Silva, Maria Joao, Lim Heng, Benedict Sim, Sin, Wai Ching, Singh, Punam, Singh, Budha Charan, Sitompul, Pompini Agustina, Sivam, Karisha, Skogen, Vegard, Smith, Sue, Smood, Benjamin, Smyth, Coilin, Smyth, Michelle, Snacken, Morgane, So, Dominic, Soh, Tze Vee, Solomon, Joshua, Solomon, Tom, Somers, Emily, Sommet, Agnès, Song, Rima, Song, Myung Jin, Song, Tae, Chia, Jack Song, Sotto, Albert, Soum, Edouard, Sousa, Marta, Sousa, Ana Chora, Uva, Maria Sousa, Souza-Dantas, Vicente, Sperry, Alexandra, Spinuzza, Elisabetta, Sriskandan, Shiranee, Stabler, Sarah, Staudinger, Thomas, Stecher, Stephanie-Susanne, Steinsvik, Trude, Stienstra, Ymkje, Stiksrud, Birgitte, Stolz, Eva, Stone, Amy, Streinu-Cercel, Adrian, Streinu-Cercel, Anca, Stuart, Ami, Stuart, David, Su, Richa, Subekti, Decy, Suen, Gabriel, Suen, Jacky Y., Sukumar, Prasanth, Sultana, Asfia, Summers, Charlotte, Supic, Dubravka, Suppiah, Deepashankari, Surovcová, Magdalena, Svistunov, Suwarti, Andrey, Syahrin, Sarah, Syrigos, Konstantinos, Sztajnbok, Jaques, Szuldrzynski, Konstanty, Tabrizi, Shirin, Taccone, Fabio S., Tagherset, Lysa, Taib, Shahdattul Mawarni, Taleb, Sara, Talsma, Jelmer, Tampubolon, Maria Lawrensia, Tan, Kim Keat, Tan, Yan Chyi, Tanaka, Hiroyuki, Tanaka, Taku, Taniguchi, Hayato, Tardivon, Coralie, Tattevin, Pierre, Taufik, M Azhari, Tawfik, Hassan, Tedder, Richard S., Tee, Tze Yuan, Teixeira, João, Tellier, Marie-Capucine, Teoh, Sze Kye, Teotonio, Vanessa, Téoulé, François, Terpstra, Pleun, Terrier, Olivier, Terzi, Nicolas, Tessier-Grenier, Hubert, Tey, Adrian, Mohd Thabit, Alif Adlan, Tham, Zhang Duan, Thangavelu, Suvintheran, Theron, Elmi, Thibault, Vincent, Thiberville, Simon-Djamel, Thill, Benoît, Thirumanickam, Jananee, Thompson, Shaun, Thomson, David, Thomson, Emma C., Thorpe, Mathew, Thanga Thurai, Surain Raaj, Thwaites, Ryan S., Tierney, Paul, Tieroshyn, Vadim, Timashev, Peter S., Timsit, Jean-François, Tissot, Noémie, Toal, Fiona, Yang Toh, Jordan Zhien, Toki, Maria, Tonby, Kristian, Tonnii, Sia Loong, Torre, Marta, Torres, Antoni, Torres-Zevallos, Hernando, Towers, Michael, Trapani, Tony, Tromeur, Cécile, Trontzas, Ioannis, Trouillon, Tiffany, Truong, Jeanne, Tual, Christelle, Tubiana, Sarah, Tuite, Helen, Turgeon, Alexis F., Turmel, Jean-Marie, Turtle, Lance C. W., Tveita, Anders, Twardowski, Pawel, Udy, Andrew, Ullrich, Roman, Uribe, Alberto, Usman, Asad, Uyeki, Timothy M., Vajdovics, Cristinava, Val-Flores, Luís, Valran, Amélie, Van de Velde, Stijn, van den Berge, Marcel, van der Palen, Job, van der Valk, Paul, Van Der Vekens, Nicky, Van der Voort, Peter, Van Der Werf, Sylvie, van Gulik, Laura, Van Hattem, Jarne, van Netten, Carolien, van Veen, Ilonka, Vanel, Noémie, Vanoverschelde, Henk, Varghese, Pooja, Varrone, Michael, Vasudayan, Shoban Raj, Vauchy, Charline, Veeran, Shaminee, Veislinger, Aurélie, Vencken, Sebastian, Ventura, Sara, Verbon, Annelies, Vidal, José Ernesto, Vieira, César, Villanueva, Joy Ann, Villoldo, Andrea, Visseaux, Benoit, Vitiello, Chiara, Vonkeman, Harald, Vuotto, Fanny, Wahab, Noor Hidayu, Wahab, Suhaila Abdul, Wahid, Nadirah Abdul, Walsh, Laura, Wang, Chih-Hsien, Webb, Steve, Wei, Jia, Wen, Tan Pei, Wesselius, Sanne, Wham, Murray, Whelan, Bryan, White, Nicole, Wicky, Paul Henri, Wiedemann, Aurélie, Wijaya, Surya Otto, Wille, Keith, Willems, Sue, Williams, Bailey, Williams, Virginie, Williams, Patricia J., Wils, Evert-Jan, Wittman, Jessica, Wong, Calvin, Wong, Xin Ci, Wong, Yew Sing, Wong, Teck Fung, Xian, Gan Ee, Xian, Lim Saio, Kuan, Pei Xuan, Xynogalas, Ioannis, Binti Mohd Yakop, Siti Rohani, Yamazaki, Masaki, Yarad, Elizabeth, Yazdanpanah, Yazdan, Liang Hing, Nicholas Yee, Yelnik, Cécile, Yeoh, Chian Hui, Yerkovich, Stephanie, Yokoyama, Toshiki, Yonis, Hodane, Yousif, Obada, Zaaqoq, Akram, Zabbe, Marion, Zahid, Masliza, Zahran, Maram, Binti Zaidan, Nor Zaila, Zambon, Maria, Zambrano, Miguel, Zanella, Alberto, Zaynah, Nurul, Zayyad, Hiba, Zoufaly, Alexander, Zucman, David, Wainstein, Marina, Spyrison, Nichola, Dai, Danyang, Ghadimi, Moji, Chavez-Iniquez, Jonathan Samuel, Rizo Topete, Lilia María, Citarella, Barbara Wanjiru, Merson, Laura, Pole, Jason, Claure-Del Granado, Rolando, Johnson, David W., Shrapnel, Sally, Abdukahil, heryl Ann, Abdulkadir, Nurul Najmee, Abe, Ryuzo, Abel, Laurent, Abrous, Amal, Absil, Lara, Acker, Andrew, Adachi, Shingo, Adrião, Diana, Al Ageel, Saleh, Ahmed, Shakeel, Ainscough, Kate, Airlangga, Eka, Aisa, Tharwat, Hssain, Ali Ait, Tamlihat, Younes Ait, Akimoto, Takako, Akmal, Ernita, Akwani, Chika, Al Qasim, Eman, Alalqam, Razi, Alberti, Angela, Al-dabbous, Tala, Alegesan, Senthilkumar, Alessi, Marta, Alex, Beatrice, Alexandre, Kévin, Al-Fares, Abdulrahman, Alfoudri, Huda, Ali, Imran, Alidjnou, Kazali Enagnon, Aliudin, Jeffrey, Alkhafajee, Qaba, Allavena, Clotilde, Allou, Nathalie, Alves, João, Alves, Rita, Alves, João Melo, Cabrita, Joana Alve, Amaral, Maria, Amira, Nur, Ampaw, Phoebe, Andini, Roberto, Andréjak, Claire, Angheben, Andrea, Angoulvant, Françoi, Ansart, Séverine, Anthonidass, Sivanesen, Antonelli, Massimo, Antunes de Brito, Carlos Alexandre, Apriyana, Ardiyan, Arabi, Yaseen, Aragao, Irene, Arancibia, Francisco, Araujo, Carolline, Arcadipane, Antonio, Archambault, Patrick, Arenz, Luka, Arlet, Jean-Benoît, Arnold-Day, Christel, Arora, Lovkesh, Arora, Rakesh, Artaud-Macari, Elise, Aryal, Diptesh, Asensio, Angel, Ashraf, Muhammad, Assie, Jean Baptiste, Asyraf, Amirul, Atif, Minahel, Atique, Anika, Auchabie, Johann, Aumaitre, Hugue, Auvet, Adrien, Azemar, Laurène, Azoulay, Cecile, Bach, Benjamin, Bachelet, Delphine, Badr, Claudine, Baillie, J. Kenneth, Baird, J Kevin, Bak, Erica, Bakakos, Agamemnon, Bakar, Nazreen Abu, Bal, Andriy, Balakrishnan, Mohanaprasanth, Balan, Valeria, Bani-Sadr, Firouzé, Barbalho, Renata, Barbosa, Nicholas Yuri, Barclay, Wendy S., Barnett, Saef Umar, Barnikel, Michaela, Barrelet, Audrey, Barrigoto, Cleide, Bartoli, Marie, Baruch, Joaquín, Basmaci, Romain, Hassin Basri, Muhammad Fadhli, Battaglini, Denise, Bauer, Jule, Bautista Rincon, Diego Fernando, Beane, Abigail, Bedossa, Alexandra, Bee, Ker Hong, Begum, Husna, Behilill, Sylvie, Beishuizen, Albertu, Beljantsev, Aleksandr, Bellemare, David, Beltrame, Anna, Beltrão, Beatriz Amorim, Beluze, Marine, Benech, Nicola, Benjiman, Lionel Eric, Benkerrou, Dehbia, Bennett, Suzanne, Benny, Binny, Bento, Luí, Berdal, Jan-Erik, Bergeaud, Delphine, Bergin, Hazel, Bernal Sobrino, José Lui, Bertoli, Giulia, Bertolino, Lorenzo, Bessis, Simon, Bevilcaqua, Sybille, Bezulier, Karine, Bhatt, Amar, Bhavsar, Krishna, Bianco, Claudia, Bidin, Farah Nadiah, Singh, Moirangthem Bikram, Humaid, Felwa Bin, Bin Kamarudin, Mohd Nazlin, Bisoffi, Zeno, Bissuel, Françoi, Biston, Patrick, Bitker, Laurent, Bitton, Jonathan, Blanco-Schweizer, Pablo, Blier, Catherine, Bloos, Frank, Blot, Mathieu, Blumberg, Lucille, Boccia, Filomena, Bodenes, Laetitia, Bogaert, Debby, Boivin, Anne-Hélène, Bolaños, Isabela, Bolze, Pierre-Adrien, Bompart, Françoi, Borges, Diogo, Borie, Raphaël, Botelho-Nevers, Elisabeth, Bouadma, Lila, Bouchaud, Olivier, Bouchez, Sabelline, Bouhmani, Dounia, Bouhour, Damien, Bouiller, Kévin, Bouillet, Laurence, Bouisse, Camile, Boureau, Anne-Sophie, Bourke, John, Bouscambert, Maude, Bousquet, Aurore, Bouziotis, Jason, Boxma, Bianca, Boyer-Besseyre, Marielle, Boylan, Maria, Bozza, Fernando Augusto, Braconnier, Axelle, Braga, Cynthia, Monteiro, Filipa Brá, Brazzi, Luca, Breen, Patrick, Breen, Dorothy, Brewster, David, Brickell, Kathy, Browne, Shaunagh, Brusse-Keizer, Marjolein, Bryda, Petra, Buchtele, Nina, Bugaeva, Polina, Buisson, Marielle, Burhan, Erlina, Burrell, Aidan, Bustos, Ingrid G., Butnaru, Deni, Cabie, André, Cabral, Susana, Caceres, Eder, Cadoz, Cyril, Garcês, Rui Caetano, Calligy, Kate, Calvache, Jose Andre, Camões, João, Campana, Valentine, Campbell, Paul, Campisi, Josie, Cantero, Mireia, Caraux-Paz, Pauline, Cardellino, Chiara Simona, Cardoso, Sofia, Cardoso, Filipe, Cardoso, Filipa, Cardoso, Nelson, Carelli, Simone, Carlier, Nicola, Carmoi, Thierry, Carney, Gayle, Carqueja, Inê, Carret, Marie-Christine, Carrier, François Martin, Carroll, Ida, Carson, Gail, Casanova, Maire-Laure, Cascão, Mariana, Casey, Siobhan, Casimiro, José, Cassandra, Bailey, Castanheira, Nidyanara, Castor-Alexandre, Guylaine, Castro, Ivo, Catarino, Ana, Catherine, François-Xavier, Cattaneo, Paolo, Cavalin, Roberta, Cavayas, Alexandro, Cervantes-Gonzalez, Minerva, Chair, Anissa, Chakveatze, Catherine, Chan, Adrienne, Chand, Meera, Chantalat Auger, Christelle, Chapplain, Jean-Marc, Charpentier, Charlotte, Chas, Julie, Chávez Iñiguez, Jonathan Samuel, Chen, Anjellica, Chen, Yih-Sharng, Chenard, Léo, Cheng, Matthew Pellan, Cheret, Antoine, Chiarabini, Thibault, Chica, Julian, Chidambaram, Suresh Kumar, Tho, Leong Chin, Chirouze, Catherine, Chiumello, Davide, Cho, Sung-Min, Cholley, Bernard, Chopin, Marie-Charlotte, Chow, Ting Soo, Chow, Yock Ping, Chua, Hiu Jian, Chua, Jonathan, Cidade, Jose Pedro, Ciullo, Anna, Clarke, Jennifer, Clohisey, Sara, Cobb, Perren J., Codan, Cassidy, Cody, Caitriona, Coelho, Alexandra, Coles, Megan, Coles, Jennifer, Colin, Gwenhaël, Collins, Michael, Colombo, Sebastiano Maria, Combs, Pamela, Connolly, Jennifer, Connor, Marie, Conrad, Anne, Conway, Elaine, Cooke, Graham S., Copland, Mary, Cordel, Hugue, Corley, Amanda, Cornelis, Sabine, Cornet, Alexander Daniel, Corpuz, Arianne Joy, Cortegiani, Andrea, Corvaisier, Grégory, Couffignal, Camille, Couffin-Cadiergues, Sandrine, Courtois, Roxane, Cousse, Stéphanie, Croonen, Sabine, Crowl, Gloria, Crump, Jonathan, Cruz, Claudina, Cruz Bermúdez, Juan Lui, Rojo, Jaime Cruz, Csete, Marc, Cullen, Ailbhe, Curley, Gerard, Curlier, Elodie, Curran, Colleen, Custodio, Paula, da Silva Filipe, Ana, Da Silveira, Charlene, Dabaliz, Al-Awwab, Dagens, Andrew, Dahly, Darren, Dalton, Heidi, Dalton, Jo, Daly, Seamu, Damas, Juliana, Daneman, Nick, Daniel, Corinne, Dankwa, Emmanuelle A., Dantas, Jorge, de Loughry, Gillian, De Montmollin, Etienne, Freitas de Oliveira França, Rafael, De Rosa, Rosanna, de Silva, Thushan, de Vries, Peter, Dean, David, Debard, Alexa, DeBenedictis, Bianca, Debray, Marie-Pierre, DeCastro, Nathalie, Dechert, William, Deconninck, Lauren, Decours, Romain, Defous, Eve, Delacroix, Isabelle, Delaveuve, Eric, Delavigne, Karen, Dell'Amore, Andrea, Delmas, Christelle, Delobel, Pierre, Delsing, Corine, Demonchy, Elisa, Denis, Emmanuelle, Deplanque, Dominique, Depuydt, Pieter, Desai, Mehul, Descamps, Diane, Desvallées, Mathilde, Dewayanti, Santi, Dhanger, Pathik, Diallo, Alpha, Diamantis, Sylvain, Da Silva, Fernanda Dia, Diaz, Juan Jose, Diaz, Rodrigo, Didier, Kévin, Diehl, Jean-Luc, Dieperink, Wim, Dimet, Jérôme, Dinot, Vincent, Diop, Fara, Diouf, Alphonsine, Dishon, Yael, Djossou, Félix, Docherty, Annemarie B., Doherty, Helen, Donnelly, Maria, Donnelly, Christl A., Donohue, Sean, Donohue, Yoann, Donohue, Chloe, Doran, Peter, Dorival, Céline, D'Ortenzio, Eric, Douglas, James Joshua, Dournon, Nathalie, Downer, Triona, Downey, Joanne, Downing, Mark, Drake, Tom, Driscoll, Aoife, Dryden, Murray, Fonseca, Claudio Duarte, Dubee, Vincent, Dubos, Françoi, Ducancelle, Alexandre, Duculan, Toni, Dudman, Susanne, Duggal, Abhijit, Dunand, Paul, Dunning, Jake, Duplaix, Mathilde, Durante-Mangoni, Emanuele, Durham, Lucian, Dussol, Bertrand, Duthoit, Juliette, Duval, Xavier, Dyrhol-Riise, Anne Margarita, Ean, Sim Choon, Echeverria-Villalobos, Marco, Edwards, Eleanor, Egan, Siobhan, El Sanharawi, Mohammed, Elapavaluru, Subbarao, Elharrar, Brigitte, Eloy, Philippine, Elshazly, Tarek, Enderle, Isabelle, Endo, Tomoyuki, Eng, Chan Chee, Engelmann, Ilka, Enouf, Vincent, Epaulard, Olivier, Escher, Martina, Esperatti, Mariano, Esperou, Hélène, Santo, Catarina Espírito, Esposito-Farese, Marina, Estevão, João, Etienne, Manuel, Ettalhaoui, Nadia, Everding, Anna Greti, Evers, Mirjam, Fabre, Marc, Fabre, Isabelle, Faheem, Amna, Fahy, Arabella, Fairfield, Cameron J., Faria, Pedro, Fateena, Hanan, Fatoni, Arie Zainul, Faure, Karine, Favory, Raphaël, Fayed, Mohamed, Feely, Niamh, Feeney, Laura, Fernandes, Jorge, Fernandes, Marília Andreia, Fernandes, Susana, Ferrand, François-Xavier, Devouge, Eglantine Ferrand, Ferrão, Joana, Ferraz, Mário, Ferreira, Sílvia, Ferreira, Bernardo, Ferreira, Benigno, Ferriere, Nicola, Ficko, Céline, Figueiredo-Mello, Claudia, Fiorda, Juan, Flament, Thoma, Flanagan, Emily, Flateau, Clara, Fletcher, Tom, Florence, Aline-Marie, Florio, Letizia Lucia, Flynn, Deirdre, Foley, Jean, Fomin, Victor, Fonseca, Tatiana, Forsyth, Simon, Foster, Denise, Foti, Giuseppe, Fourn, Erwan, Fowler, Robert A., Fraher, Marianne, Franch-Llasat, Diego, Fraser, John F., Fraser, Christophe, Freire, Marcela Vieira, Ribeiro, Ana Freita, Friedrich, Caren, Fritz, Ricardo, Fry, Stéphanie, Fuentes, Nora, Fukuda, Masahiro, G, Argin, Gaborieau, Valérie, Gaci, Rostane, Gagliardi, Massimo, Gagnard, Jean-Charle, Gagneux-Brunon, Amandine, Gaião, Sérgio, Skeie, Linda Gail, Gallagher, Phil, Gamble, Carrol, Gani, Yasmin, Garan, Arthur, Garcia, Rebekha, Barrio, Noelia García, Garcia-Gallo, Esteban, Garot, Deni, Garrait, Valérie, Gault, Nathalie, Gavin, Aisling, Gavrylov, Anatoliy, Gaymard, Alexandre, Gebauer, Johanne, Geraud, Eva, Morlaes, Louis Gerbaud, Germano, Nuno, Ghosn, Jade, Giani, Marco, Gibson, Je, Gigante, Tristan, Gilg, Morgane, Gilroy, Elaine, Giordano, Guillermo, Girvan, Michelle, Gissot, Valérie, Glikman, Daniel, Glybochko, Petr, Gnall, Eric, Goehringer, Françoi, Goffard, Jean-Christophe, Goh, Jin Yi, Golob, Jonathan, Gominet, Marie, Gonzalez, Alicia, Gordon, Patricia, Gorenne, Isabelle, Gormley, Conor, Goubert, Laure, Goujard, Cécile, Goulenok, Tiphaine, Grable, Margarite, Grandin, Edward Wilson, Granier, Pascal, Grasselli, Giacomo, Green, Christopher A., Greenhalf, William, Greffe, Segolène, Grieco, Domenico Luca, Griffee, Matthew, Griffiths, Fiona, Grigoras, Ioana, Groenendijk, Albert, Gruner, Heidi, Gu, Yusing, Guedj, Jérémie, Guego, Martin, Guellec, Dewi, Guerreiro, Daniela, Guery, Romain, Guillaumot, Anne, Guilleminault, Laurent, Guimarães de Castro, Maisa, Guimard, Thoma, Haalboom, Marieke, Haber, Daniel, Habraken, Hannah, Hachemi, Ali, Hadri, Nadir, Hakak, Sheeba, Hall, Adam, Hall, Matthew, Halpin, Sophie, Hamer, Ansley, Hamers, Raph L., Hamidfar, Rebecca, Hammond, Terese, Hammond, Naomi, Han, Lim Yuen, Hao, Kok Wei, Hardwick, Hayley, Harrison, Ewen M., Harrison, Janet, Hartman, Alan, Hashmi, Junaid, Hayes, Ailbhe, Hays, Leanne, Heerman, Jan, Heggelund, Lar, Hendry, Ro, Hennessy, Martina, Hentzien, Maxime, Hernandez, Diana, Hershey, Andrew, Hesstvedt, Liv, Higgins, Eibhlin, Higgins, Dawn, Higgins, Rupert, Hinchion, Rita, Hinton, Samuel, Hiraiwa, Hiroaki, Hitoto, Hikombo, Ho, Antonia, Ho, Yi Bin, Hoctin, Alexandre, Hoffmann, Isabelle, Hoh, Wei Han, Hoiting, Oscar, Holt, Rebecca, Holter, Jan Cato, Horby, Peter, Hoshino, Kota, Houas, Ikram, Hough, Catherine L., Houltham, Stuart, Ming-Yang Hsu, Jimmy, Hulot, Jean-Sébastien, Hurd, Abby, Ijaz, Samreen, Ikram, M. Arfan, Illes, Hajnal-Gabriela, Imbert, Patrick, Inácio, Hugo, Ing, Yun Sii, Ippolito, Mariachiara, Isgett, Sarah, Isidoro, Tiago, Ismail, Nadiah, Isnard, Margaux, Itai, Junji, Ivulich, Daniel, Jaafar, Danielle, Jaafoura, Salma, Jabot, Julien, Jackson, Clare, Jaquet, Pierre, Jassat, Waasila, Jaud-Fischer, Coline, Jaureguiberry, Stéphane, Jego, Florence, Jelani, Anilawati Mat, Jenum, Synne, Joe, Ong Yiaw, Jorge García, Ruth N., Joseph, Mark, Joseph, Cédric, Jourdain, Mercé, Jouvet, Philippe, Jung, Anna, Juzar, Dafsah, Kafif, Ouifiya, Kaguelidou, Florentia, Kaisbain, Neerusha, Kaleesvran, Thavamany, Kali, Sabina, Kalomoiri, Smaragdi, Ayadi Kamaluddin, Muhammad Aisar, Che Kamaruddin, Zul Amali, Kamarudin, Nadiah, Kandamby, Darshana Hewa, Kandel, Chri, Kang, Kong Yeow, Karpayah, Pratap, Kartsonaki, Christiana, Kasugai, Daisuke, Kataria, Anant, Katz, Kevin, Kaur, Aasmine, Kay, Christy, Kayyali, Lamee, Keating, Seán, Kelly, Claire, Kelly, Yvelynne, Kelly, Andrea, Kelly, Niamh, Kelly, Aoife, Kelly, Sadie, Kelsey, Maeve, Kennedy, Ryan, Kennon, Kalynn, Kernan, Maeve, Kerroumi, Youne, Keshav, Sharma, Khalid, Imrana, Khalil, Antoine, Khan, Coralie, Khan, Irfan, Kho, Michelle E., Khoo, Saye, Khoo, Ryan, Khoo, Denisa, Kiat, Khor How, Kida, Yuri, Kiiza, Peter, Granerud, Beathe Kiland, Kildal, Anders Benjamin, Kim, Jae Burm, Kimmoun, Antoine, Kitamura, Nobuya, Klenerman, Paul, Klont, Rob, Bekken, Gry Kloumann, Knight, Stephen R., Komatsu, Mamoru, Korten, Volkan, Kpangon, Arsène, Krawczyk, Karolina, Krishnan, Sudhir, Krishnan, Vinothini, Kruglova, Oksana, Kumar, Deepali, Kumar, Ganesh, Tirupakuzhi Vijayaraghavan, Bharath Kumar, Vecham, Pavan Kumar, Kuriakose, Dinesh, Kurtzman, Ethan, Kutsogiannis, Demetrio, Kutsyna, Galyna, Kyriakoulis, Konstantino, Lachatre, Marie, Lacoste, Marie, Laffey, John G., Lafhej, Nadhem, Lagrange, Marie, Laine, Fabrice, Lairez, Olivier, Lalueza, Antonio, Lambert, Marc, Langelot-Richard, Marie, Langlois, Vincent, Lantang, Eka Yudha, Lanza, Marina, Laouénan, Cédric, Laribi, Samira, Lariviere, Delphine, Lasry, Stéphane, Launay, Odile, Laureillard, Didier, Lavie-Badie, Yoan, Law, Andy, Lawrence, Teresa, Lawrence, Cassie, Le, Minh, Le Bihan, Clément, Le Bris, Cyril, Le Falher, George, Le Fevre, Lucie, Le Hingrat, Quentin, Le Maréchal, Marion, Le Mestre, Soizic, Le Moal, Gwenaël, Le Moing, Vincent, Le Nagard, Hervé, Le Turnier, Paul, Lee, Todd C., Lee, Su Hwan, Lee, Jame, Lee, Jennifer, Lee, Heng Gee, Lee, Biing Horng, Lee, Yi Lin, Leeming, Gary, Lefebvre, Laurent, Lefebvre, Bénédicte, Lefèvre, Benjamin, LeGac, Sylvie, Lelievre, Jean-Daniel, Lellouche, Françoi, Lemaignen, Adrien, Lemee, Véronique, Lemeur, Anthony, Lemmink, Gretchen, Lene, Ha Sha, Leone, Michela, Leone, Marc, Lepiller, Quentin, Lescure, François-Xavier, Lesens, Olivier, Lesouhaitier, Mathieu, Lester-Grant, Amy, Letrou, Sophie, Levy, Yve, Levy, Bruno, Levy-Marchal, Claire, L'Her, Erwan, Bassi, Gianluigi Li, Liang, Janet, Liegeon, Geoffrey, Lim, Wei Shen, Lim, Kah Chuan, Lima, Chantre, Lina, Bruno, Lina, Lim, Lind, Andrea, Lingas, Guillaume, Lion-Daolio, Sylvie, Liu, Keibun, Livrozet, Marine, Lizotte, Patricia, Lolong, Navy, Loon, Leong Chee, Lopes, Diogo, Lopez-Colon, Dalia, Loschner, Anthony L., Loubet, Paul, Loufti, Bouchra, Louis, Guillame, Lourenco, Silvia, Low, Lee, Lowik, Marije, Loy, Jia Shyi, Lucet, Jean Christophe, Bermejo, Carlos Lumbrera, Luna, Carlos M., Lungu, Olguta, Lunn, Mile, Luong, Liem, Luque, Nestor, Luton, Dominique, Lyons, Ruth, Maasikas, Olavi, Mabiala, Oryane, Machado, Sara, Machado, Moïse, Macheda, Gabriel, Madiha, Hashmi, Maestro de la Calle, Guillermo, Mahieu, Rafael, Mahy, Sophie, Maier, Lars S., Maillet, Mylène, Maitre, Thoma, Malfertheiner, Maximilian, Malik, Nadia, Mallon, Paddy, Malvy, Deni, Manda, Victoria, Mandelbrot, Laurent, Manetta, Frank, Mankikian, Julie, Manning, Edmund, Manuel, Aldric, Sant`Ana Malaque, Ceila Maria, Marino, Flávio, Markowicz, Samuel, Marques, Ana, Marsh, Brian, Marsh, Laura, Marshal, Megan, Marshall, John, Martelli, Celina Turchi, Martin, Emily, Martin-Blondel, Guillaume, Martinez, F. Eduardo, Martin-Loeches, Ignacio, Martinot, Martin, Martins, João, Martins, Ana, Rego, Caroline Martin, Martucci, Gennaro, Martynenko, Olga, Marwali, Eva Miranda, Marzukie, Marsilla, Maslove, David, Mason, Sabina, Mat Nor, Mohd Basri, Matan, Moshe, Mathieu, Daniel, Mattei, Mathieu, Maulin, Laurence, Maxwell, Michael, Mazzoni, Thierry, Sweeney, Lisa Mc, McArthur, Colin, McCanny, Peter, McCarthy, Anne, McCarthy, Aine, McCloskey, Colin, McConnochie, Rachael, McDermott, Sherry, McDonald, Sarah E., McElroy, Aine, McElwee, Samuel, McEneany, Victoria, McEvoy, Natalie, McGeer, Allison, McKay, Chri, McKeown, Johnny, McLean, Kenneth A., McNicholas, Bairbre, McPartlan, Elaine, Meaney, Edel, Mear-Passard, Cécile, Mechlin, Maggie, Mehkri, Omar, Mele, Ferruccio, Menon, Kusum, Mentré, France, Mentzer, Alexander J., Mercier, Noémie, Mercier, Emmanuelle, Merckx, Antoine, Mergeay-Fabre, Mayka, Mergler, Blake, Mesquita, António, Metwally, Osama, Meybeck, Agnè, Meyer, Dan, Meynert, Alison M., Meysonnier, Vanina, Meziane, Amina, Mezidi, Mehdi, Michelanglei, Céline, Michelet, Isabelle, Mihelis, Efstathia, Mihnovit, Vladislav, Miller, Jennene, Misnan, Nor Arisah, Mohamed, Tahira Jamal, Eliza Mohamed, Nik Nur, Moin, Asma, Molinos, Elena, Molloy, Brenda, Monahan, Sinead, Mone, Mary, Monteiro, Agostinho, Montes, Claudia, Montrucchio, Giorgia, Moore, Shona C., Moore, Sarah, Cely, Lina Morale, Moro, Lucia, Motherway, Catherine, Motos, Ana, Mouquet, Hugo, Perrot, Clara Mouton, Moyet, Julien, Mudara, Caroline, Muh, Ng Yong, Muhamad, Dzawani, Mullaert, Jimmy, Müller, Fredrik, Müller, Karl Erik, Munblit, Daniel, Murphy, Aisling, Murphy, Lorna, Murray, Patrick, Murris, Marlène, Murthy, Sriniva, Musaab, Himed, Muyandy, Gugapriyaa, Myrodia, Dimitra Melia, Nagpal, Dave, Nagrebetsky, Alex, Narasimhan, Mangala, Narayanan, Nageswaran, Neant, Nadège, Necsoi, Coca, Nekliudov, Nikita, Neto, Raul, Neumann, Emily, Ng, Pauline Yeung, Ng, Wing Yiu, Nghi, Anthony, Nguyen, Duc, Choileain, Orna Ni, Leathlobhair, Niamh Ni, Nichol, Alistair D., Nitayavardhana, Prompak, Nonas, Stephanie, Mohd Noordin, Nurul Amani, Noret, Marion, Izzati Norharizam, Nurul Faten, Norman, Lisa, Notari, Alessandra, Noursadeghi, Mahdad, Nseir, Saad, Nusantara, Dwi Utomo, Nyamankolly, Elsa, Brien, Fionnuala O., Callaghan, Annmarie O., O'Callaghan, Annmarie, Occhipinti, Giovanna, OConnor, Derbrenn, Ogura, Takayuki, O'Halloran, Sophie, O'Hearn, Katie, Ohshimo, Shinichiro, Oliveira, João, Olliaro, Piero L., O'Neil, Conar, Ong, David S.Y., Ong, Jee Yan, Oosthuyzen, Wilna, Opavsky, Anne, Openshaw, Peter, Orozco-Chamorro, Claudia Milena, Ortoleva, Jamel, Osatnik, Javier, O'Shea, Linda, O'Sullivan, Miriam, Othman, Siti Zubaidah, Ouamara, Nadia, Ouissa, Rachida, Oziol, Eric, Pagadoy, Maïder, Pages, Justine, Palmarini, Massimo, Panarello, Giovanna, Panda, Prasan Kumar, Pang, Lai Hui, Panigada, Mauro, Pansu, Nathalie, Papadopoulos, Aurélie, Parke, Rachael, Pasquier, Jérémie, Pastene, Bruno, Patauner, Fabian, Pathmanathan, Mohan Da, Patricio, Patricia, Patrier, Juliette, Patterson, Lisa, Paul, Mical, Paul, Christelle, Paulos, Jorge, Paxton, William A., Payen, Jean-Françoi, Peake, Sandra L., Peariasamy, Kalaiarasu, Jiménez, Miguel Pedrera, Peek, Giles J., Peelman, Florent, Peiffer-Smadja, Nathan, Peigne, Vincent, Pejkovska, Mare, Pelosi, Paolo, Peltan, Ithan D., Pereira, Rui, Perez, Daniel, Periel, Lui, Perpoint, Thoma, Pesenti, Antonio, Pestre, Vincent, Petrou, Lenka, Petrovic, Michele, Petrov-Sanchez, Ventzislava, Pettersen, Frank Olav, Peytavin, Gille, Pharand, Scott, Piagnerelli, Michael, Picard, Walter, Picone, Olivier, Pierobon, Carola, Piersma, Djura, Pimentel, Carlo, Piquard, Valentine, Pires, Catarina, Pironneau, Isabelle, Piroth, Lionel, Pitaloka, Ayodhia, Piubelli, Chiara, Pius, Riinu, Plantier, Laurent, Png, Hon Shen, Poissy, Julien, Pokeerbux, Ryadh, Poli, Sergio, Pollakis, Georgio, Ponscarme, Diane, Porto, Diego Basto, Post, Andra-Mari, Postma, Douwe F., Povoa, Pedro, Póvoas, Diana, Powis, Jeff, Prapa, Sofia, Preau, Sébastien, Prebensen, Christian, Preiser, Jean-Charle, Prinssen, Anton, Proença, Lucia, Pudota, Sravya, Puéchal, Oriane, Semedi, Bambang Pujo, Purcell, Gregory, Quesada, Luisa, González, Víctor Quiró, Quist-Paulsen, Else, Quraishi, Mohammed, Qutishat, Fadi, Rabaud, Christian, Rafael, Aldo, Rafiq, Marie, Rahardjani, Mutia, Rahimi, Amir Kamel, Rahman, Rozanah Abd, Haji Ab Rahman, Ahmad Kashfi, Rainieri, Fernando, Rajahram, Giri Shan, Ramakrishnan, Nagarajan, Ramalho, José, Ramli, Ahmad Afiq, Rammaert, Blandine, Ramos, Grazielle Viana, Ranjan, Ritika, Rapp, Christophe, Rasmin, Menaldi, Rätsep, Indrek, Ravi, Tharmini, Real, Andre, Rebaudet, Stanisla, Redl, Sarah, Reeve, Brenda, Reid, Liadain, Reikvam, Dag Henrik, Reis, Renato, Remy, Martine, Ren, Hongru, Resseguier, Anne-Sophie, Revest, Matthieu, Rewa, Oleksa, Reyes, Tiago, Reyes, Luis Felipe, Ribeiro, Maria Ine, Richardson, David, Richardson, Denise, Richier, Laurent, Atikah Ahmad Ridzuan, Siti Nurul, Rios, Ana L., Rishu, Asgar, Rispal, Patrick, Risso, Karine, Rizer, Nichola, Robba, Chiara, Roberto, André, Roberts, Stephanie, Robertson, David L., Robineau, Olivier, Roche-Campo, Ferran, Rodari, Paola, Rodeia, Simão, Roessler, Bernhard, Roger, Pierre-Marie, Rojek, Amanda, Romaru, Juliette, Roncon-Albuquerque, Roberto, Roriz, Mélanie, Rosa-Calatrava, Manuel, Rose, Michael, Rosenberger, Dorothea, Rossanese, Andrea, Rossetti, Matteo, Rossignol, Bénédicte, Rossignol, Patrick, Rousset, Stella, Roy, Carine, Roze, Benoît, Russell, Clark D., Ryan, Maria, Ryan, Maeve, Ryckaert, Steffi, Holten, Aleksander Rygh, Saba, Isabela, Sadat, Musharaf, Sahraei, Valla, Saint-Gilles, Maximilien, Sakiyalak, Pranya, Salazar, Leonardo, Sales, Gabriele, Sallaberry, Stéphane, Gandonniere, Charlotte Salmon, Salvator, Hélène, Sanchez, Emely, Sanchez, Olivier, Sanchez-Miralles, Angel, Sancho-Shimizu, Vanessa, Sandhu, Gyan, Sandhu, Zulfiqar, Sandrine, Pierre-Françoi, Sandulescu, Oana, Santos, Marlene, Sarfo-Mensah, Shirley, Sarmiento, Iam Claire E., Sarton, Benjamine, Satyapriya, Sree, Satyawati, Rumaisah, Saviciute, Egle, Saw, Yen Tsen, Schaffer, Justin, Schermer, Tjard, Scherpereel, Arnaud, Schneider, Marion, Schroll, Stephan, Schwameis, Michael, Scott, Janet T., Scott-Brown, Jame, Sedillot, Nichola, Seitz, Tamara, Selvarajoo, Mageswari, Semaille, Caroline, Semple, Malcolm G., Senian, Rasidah Bt, Senneville, Eric, Sepulveda, Claudia, Sequeira, Filipa, Sequeira, Tânia, Neto, Ary Serpa, Balazote, Pablo Serrano, Shadowitz, Ellen, Shahidan, Syamin Asyraf, Shamsah, Mohammad, Shankar, Anuraj, Sharjeel, Shaikh, Sharma, Pratima, Shaw, Catherine A., Shaw, Victoria, Sheenan, John Robert, Shi, Haixia, Shime, Nobuaki, Shimizu, Hiroaki, Shimizu, Keiki, Shum, Hoi Ping, Mohammed, Nassima Si, Siang, Ng Yong, Sibiude, Jeanne, Siddiqui, Atif, Sigfrid, Louise, Sillaots, Piret, Silva, Catarina, Silva, Rogério, Silva, Maria Joao, Lim Heng, Benedict Sim, Sin, Wai Ching, Singh, Punam, Singh, Budha Charan, Sitompul, Pompini Agustina, Sivam, Karisha, Skogen, Vegard, Smith, Sue, Smood, Benjamin, Smyth, Coilin, Smyth, Michelle, Snacken, Morgane, So, Dominic, Soh, Tze Vee, Solomon, Joshua, Solomon, Tom, Somers, Emily, Sommet, Agnè, Song, Rima, Song, Myung Jin, Song, Tae, Chia, Jack Song, Sotto, Albert, Soum, Edouard, Sousa, Marta, Sousa, Ana Chora, Uva, Maria Sousa, Souza-Dantas, Vicente, Sperry, Alexandra, Spinuzza, Elisabetta, Sriskandan, Shiranee, Stabler, Sarah, Staudinger, Thoma, Stecher, Stephanie-Susanne, Steinsvik, Trude, Stienstra, Ymkje, Stiksrud, Birgitte, Stolz, Eva, Stone, Amy, Streinu-Cercel, Adrian, Streinu-Cercel, Anca, Stuart, Ami, Stuart, David, Su, Richa, Subekti, Decy, Suen, Gabriel, Suen, Jacky Y., Sukumar, Prasanth, Sultana, Asfia, Summers, Charlotte, Supic, Dubravka, Suppiah, Deepashankari, Surovcová, Magdalena, Svistunov, Suwarti, Andrey, Syahrin, Sarah, Syrigos, Konstantino, Sztajnbok, Jaque, Szuldrzynski, Konstanty, Tabrizi, Shirin, Taccone, Fabio S., Tagherset, Lysa, Taib, Shahdattul Mawarni, Taleb, Sara, Talsma, Jelmer, Tampubolon, Maria Lawrensia, Tan, Kim Keat, Tan, Yan Chyi, Tanaka, Hiroyuki, Tanaka, Taku, Taniguchi, Hayato, Tardivon, Coralie, Tattevin, Pierre, Taufik, M Azhari, Tawfik, Hassan, Tedder, Richard S., Tee, Tze Yuan, Teixeira, João, Tellier, Marie-Capucine, Teoh, Sze Kye, Teotonio, Vanessa, Téoulé, Françoi, Terpstra, Pleun, Terrier, Olivier, Terzi, Nicola, Tessier-Grenier, Hubert, Tey, Adrian, Mohd Thabit, Alif Adlan, Tham, Zhang Duan, Thangavelu, Suvintheran, Theron, Elmi, Thibault, Vincent, Thiberville, Simon-Djamel, Thill, Benoît, Thirumanickam, Jananee, Thompson, Shaun, Thomson, David, Thomson, Emma C., Thorpe, Mathew, Thanga Thurai, Surain Raaj, Thwaites, Ryan S., Tierney, Paul, Tieroshyn, Vadim, Timashev, Peter S., Timsit, Jean-Françoi, Tissot, Noémie, Toal, Fiona, Yang Toh, Jordan Zhien, Toki, Maria, Tonby, Kristian, Tonnii, Sia Loong, Torre, Marta, Torres, Antoni, Torres-Zevallos, Hernando, Towers, Michael, Trapani, Tony, Tromeur, Cécile, Trontzas, Ioanni, Trouillon, Tiffany, Truong, Jeanne, Tual, Christelle, Tubiana, Sarah, Tuite, Helen, Turgeon, Alexis F., Turmel, Jean-Marie, Turtle, Lance C.W., Tveita, Ander, Twardowski, Pawel, Udy, Andrew, Ullrich, Roman, Uribe, Alberto, Usman, Asad, Uyeki, Timothy M., Vajdovics, Cristinava, Val-Flores, Luí, Valran, Amélie, Van de Velde, Stijn, van den Berge, Marcel, van der Palen, Job, van der Valk, Paul, Van Der Vekens, Nicky, Van der Voort, Peter, Van Der Werf, Sylvie, van Gulik, Laura, Van Hattem, Jarne, van Netten, Carolien, van Veen, Ilonka, Vanel, Noémie, Vanoverschelde, Henk, Varghese, Pooja, Varrone, Michael, Vasudayan, Shoban Raj, Vauchy, Charline, Veeran, Shaminee, Veislinger, Aurélie, Vencken, Sebastian, Ventura, Sara, Verbon, Annelie, Vidal, José Ernesto, Vieira, César, Villanueva, Joy Ann, Villoldo, Andrea, Visseaux, Benoit, Vitiello, Chiara, Vonkeman, Harald, Vuotto, Fanny, Wahab, Noor Hidayu, Wahab, Suhaila Abdul, Wahid, Nadirah Abdul, Walsh, Laura, Wang, Chih-Hsien, Webb, Steve, Wei, Jia, Wen, Tan Pei, Wesselius, Sanne, Wham, Murray, Whelan, Bryan, White, Nicole, Wicky, Paul Henri, Wiedemann, Aurélie, Wijaya, Surya Otto, Wille, Keith, Willems, Sue, Williams, Bailey, Williams, Virginie, Williams, Patricia J., Wils, Evert-Jan, Wittman, Jessica, Wong, Calvin, Wong, Xin Ci, Wong, Yew Sing, Wong, Teck Fung, Xian, Gan Ee, Xian, Lim Saio, Kuan, Pei Xuan, Xynogalas, Ioanni, Binti Mohd Yakop, Siti Rohani, Yamazaki, Masaki, Yarad, Elizabeth, Yazdanpanah, Yazdan, Liang Hing, Nicholas Yee, Yelnik, Cécile, Yeoh, Chian Hui, Yerkovich, Stephanie, Yokoyama, Toshiki, Yonis, Hodane, Yousif, Obada, Zaaqoq, Akram, Zabbe, Marion, Zahid, Masliza, Zahran, Maram, Binti Zaidan, Nor Zaila, Zambon, Maria, Zambrano, Miguel, Zanella, Alberto, Zaynah, Nurul, Zayyad, Hiba, Zoufaly, Alexander, and Zucman, David

Subjects
acute kidney injury, covid-19, Nephrology
Abstract

Introduction Acute kidney injury (AKI) has been identified as one of the most common and significant problems in hospitalized patients with COVID-19. However, studies examining the relationship between COVID-19 and AKI in low- and low-middle income countries (LLMIC) are lacking. Given that AKI is known to carry a higher mortality rate in these countries, it is important to understand differences in this population. Methods This prospective, observational study examines the AKI incidence and characteristics of 32,210 patients with COVID-19 from 49 countries across all income levels who were admitted to an intensive care unit during their hospital stay. Results Among patients with COVID-19 admitted to the intensive care unit (ICU), AKI incidence was highest in patients in LLMIC, followed by patients in upper-middle income countries (UMIC) and high-income countries (HIC) (53%, 38%, and 30%, respectively), whereas dialysis rates were lowest among patients with AKI from LLMIC and highest among those from HIC (27% vs. 45%). Patients with AKI in LLMIC had the largest proportion of community-acquired AKI (CA-AKI) and highest rate of in-hospital death (79% vs. 54% in HIC and 66% in UMIC). The association between AKI, being from LLMIC and in-hospital death persisted even after adjusting for disease severity. Conclusions AKI is a particularly devastating complication of COVID-19 among patients from poorer nations where the gaps in accessibility and quality of healthcare delivery have a major impact on patient outcomes.

Published
2023
Full Text
View/download PDF

28. Esketamine in treatment-resistant depression patients comorbid with substance-use disorder: A viewpoint on its safety and effectiveness in a subsample of patients from the REAL-ESK study

Author

Stefania Chiappini, Giacomo d'Andrea, Sergio De Filippis, Marco Di Nicola, Ileana Andriola, Roberta Bassetti, Stefano Barlati, Mauro Pettorruso, Stefano Sensi, Massimo Clerici, Bernardo Dell'Osso, Antonio Vita, and Giovanni Martinotti

Subjects
Pharmacology, Psychiatry and Mental health, Neurology, Esketamine, Affective disorder, SUD, Substance use disorder, TRD, Treatment-resistant depression, Pharmacology (medical), Neurology (clinical), Biological Psychiatry
Published
2023
Full Text
View/download PDF

31. The Personalized Acne Treatment Tool — Recommendations to facilitate a patient-centered approach to acne management from the Personalizing Acne: Consensus of Experts

Author

Alison M. Layton, Andrew Alexis, Hilary Baldwin, Vincenzo Bettoli, James Del Rosso, Thomas Dirschka, Brigitte Dréno, Linda Stein Gold, Julie Harper, Joo Yeon Ko, Khaled Al Nuaimi, Hazel H. Oon, Murlidhar Rajagopalan, Marco Rocha, Jo-Ann See, Jonathan Weiss, and Jerry Tan

Subjects
Dermatology
Published
2023
Full Text
View/download PDF

32. CT imaging of an unusual malignant inguinal mass: metastatic parafunicular dedifferentiated liposarcoma

Author

Guido Marzocchi, Mattia Gentilini, Marco Cavini, and Luigi Lovato

Subjects
Male, Spermatic Cord, Genital Neoplasms, Male, Humans, Neoplasms, Second Primary, General Medicine, Liposarcoma, Tomography, X-Ray Computed
Abstract

A man in his 50s was redirected by his general practitioner to our University Hospital for a radiological evaluation after the complaint of a left inguinal swelling. The preliminary ultrasound and CT scan showed a left parafunicolar mass located between the root of the penis and the spermatic cord. The lesion was biopsied shortly after and histologically diagnosed as a dedifferentiated liposarcoma. The patient underwent a cycle of neoadjuvant radiotherapy, which proved to be ineffective. He was then subjected to an organ sparing surgical removal of the mass, followed by a second organ sparing removal of some residual disease. The last CT scan showed absence of the inguinal disease; however, lung and hepatic metastasis were detected, which are scheduled to be treated with a course of chemotherapy and radiofrequency.

Published
2024

33. Pandemic Phase-Adjusted Analysis of COVID-19 Outcomes Reveals Reduced Intrinsic Vulnerability and Substantial Vaccine Protection From Severe Acute Respiratory Syndrome Coronavirus 2 in Patients With Breast Cancer

Author

Marco Tagliamento, Alessandra Gennari, Matteo Lambertini, Ramon Salazar, Nadia Harbeck, Lucia Del Mastro, Juan Aguilar-Company, Mark Bower, Rachel Sharkey, Alessia Dalla Pria, Andrea Plaja, Amanda Jackson, Jasmine Handford, Ailsa Sita-Lumsden, Clara Martinez-Vila, Marta Matas, Ana Miguel Rodriguez, Bruno Vincenzi, Giuseppe Tonini, Alexia Bertuzzi, Joan Brunet, Paolo Pedrazzoli, Francesca D'Avanzo, Federica Biello, Alasdair Sinclair, Alvin J.X. Lee, Sabrina Rossi, Gianpiero Rizzo, Oriol Mirallas, Isabel Pimentel, Maria Iglesias, Ana Sanchez de Torre, Annalisa Guida, Rossana Berardi, Alberto Zambelli, Carlo Tondini, Marco Filetti, Francesca Mazzoni, Uma Mukherjee, Nikolaos Diamantis, Alessandro Parisi, Avinash Aujayeb, Aleix Prat, Michela Libertini, Salvatore Grisanti, Maura Rossi, Federica Zoratto, Daniele Generali, Cristina Saura, Gary H. Lyman, Nicole M. Kuderer, David J. Pinato, and Alessio Cortellini

Subjects
Cancer Research, breast cancer, Oncology, cancers, COVID-19 outcomes
Abstract

PURPOSE Although representing the majority of newly diagnosed cancers, patients with breast cancer appear less vulnerable to COVID-19 mortality compared with other malignancies. In the absence of patients on active cancer therapy included in vaccination trials, a contemporary real-world evaluation of outcomes during the various pandemic phases, as well as of the impact of vaccination, is needed to better inform clinical practice. METHODS We compared COVID-19 morbidity and mortality among patients with breast cancer across prevaccination (February 27, 2020-November 30, 2020), Alpha-Delta (December 1, 2020-December 14, 2021), and Omicron (December 15, 2021-January 31, 2022) phases using OnCovid registry participants (ClinicalTrials.gov identifier: NCT04393974 ). Twenty-eight-day case fatality rate (CFR28) and COVID-19 severity were compared in unvaccinated versus double-dosed/boosted patients (vaccinated) with inverse probability of treatment weighting models adjusted for country of origin, age, number of comorbidities, tumor stage, and receipt of systemic anticancer therapy within 1 month of COVID-19 diagnosis. RESULTS By the data lock of February 4, 2022, the registry counted 613 eligible patients with breast cancer: 60.1% (n = 312) hormone receptor–positive, 25.2% (n = 131) human epidermal growth factor receptor 2–positive, and 14.6% (n = 76) triple-negative. The majority (61%; n = 374) had localized/locally advanced disease. Median age was 62 years (interquartile range, 51-74 years). A total of 193 patients (31.5%) presented ≥ 2 comorbidities and 69% (n = 330) were never smokers. In total, 392 (63.9%), 164 (26.8%), and 57 (9.3%) were diagnosed during the prevaccination, Alpha-Delta, and Omicron phases, respectively. Analysis of CFR28 demonstrates comparable estimates of mortality across the three pandemic phases (13.9%, 12.2%, 5.3%, respectively; P = .182). Nevertheless, a significant improvement in outcome measures of COVID-19 severity across the three pandemic time periods was observed. Importantly, when reported separately, unvaccinated patients from the Alpha-Delta and Omicron phases achieved comparable outcomes to those from the prevaccination phase. Of 566 patients eligible for the vaccination analysis, 72 (12.7%) were fully vaccinated and 494 (87.3%) were unvaccinated. We confirmed with inverse probability of treatment weighting multivariable analysis and following a clustered robust correction for participating center that vaccinated patients achieved improved CFR28 (odds ratio [OR], 0.19; 95% CI, 0.09 to 0.40), hospitalization (OR, 0.28; 95% CI, 0.11 to 0.69), COVID-19 complications (OR, 0.16; 95% CI, 0.06 to 0.45), and reduced requirement of COVID-19–specific therapy (OR, 0.24; 95% CI, 0.09 to 0.63) and oxygen therapy (OR, 0.24; 95% CI, 0.09 to 0.67) compared with unvaccinated controls. CONCLUSION Our findings highlight a consistent reduction of COVID-19 severity in patients with breast cancer during the Omicron outbreak in Europe. We also demonstrate that even in this population, a complete severe acute respiratory syndrome coronavirus 2 vaccination course is a strong determinant of improved morbidity and mortality from COVID-19.

Published
2023
Full Text
View/download PDF

35. Probing Italy: A Scanning Probe Microscopy Storyline

Author

Franco Dinelli, Marco Brucale, Francesco Valle, Cesare Ascoli, Bruno Samorì, Marco Sartore, Manuela Adami, Riccardo Galletti, Stefano Prato, Barbara Troian, and Cristiano Albonetti

Subjects
General Medicine
Abstract

Starting from the late 1980’s, scanning probe microscopy has progressively diffused in Italy until today. In this paper, we provide a brief account of the main historical events and a current picture of the distribution of the active groups. A survey was prepared by LimeSurvey, made of six sections asking for personal and institutional data, human resources, equipment available, fields of interest, research projects, educational/dissemination activities, and two relevant publications in the last six years. It turns out that the Italian community includes more than seventy groups and two companies. It is widely diffused, although mostly concentrated near large academic and research institutions, often in locations where prominent Italian researchers have operated. This community is active in many scientific fields and can produce research of high international quality. It shows a wide competence, as proven by the list of research works published in journals ranked within the top 20% class. The diffusion of SPM microscopes in industry is still sporadic, possibly due to extensive collaborations between the research institutions and industries themselves. The authors hope that this work might be useful to the community and beyond, and that it might stimulate the formation of a more structured network.

Published
2023
Full Text
View/download PDF

36. From Digital Restitution to Structural Analysis of a Historical Adobe Building: The Escuela José Mariano Méndez in El Salvador

Author

Silvia Santini, Marco Canciani, Vittoria Borghese, Valerio Sabbatini, Claudio Sebastiani, Santini, Silvia, Canciani, Marco, Borghese, Vittoria, Sabbatini, Valerio, and Sebastiani, Claudio

Subjects
laser scanner, FEM, Archeology, historical adobe building, HBIM, Materials Science (miscellaneous), Conservation
Abstract

Nowadays, the research in the fields of conservation and restoration is focusing on recording large amounts of data and information in order to obtain highly accurate surveys that include most details of constructions. Documenting and surveying are fundamental activities in achieving the successful preservation of cultural heritage, but also in implementing efficient strengthening interventions of structures. The applications of methods and techniques that link the disciplines of geometrical surveys and structural analyses are still fragmented, and further research is necessary to fully transfer site information into structural models. In this article, the authors propose a methodology with which to link different restoration fields, with the aim of highlighting the strengths and weaknesses of the interoperability between surveys (carried out through detailed restitution from point clouds), heritage building information modeling (HBIM), and structural analyses to connect three different disciplines. The goal is to find a synthesis model that brings together historical and geometric characteristics, but also physical–mechanical properties, for a structural evaluation through a finite element model (FEM). The case study of the Escuela José Mariano Méndez is analyzed, an extremely damaged historical adobe building in Santa Ana, the second largest city of El Salvador; it is considered fundamental to the national economy, particularly after the “coffee boom” in the late 1800s. The site, located near the historic center, is also known as “Antigua Escuela de Artes y Oficios” and embodies the architectural traditions of the region, being built in adobe and stone. Roma Tre University and the Secretaría de Cultura de la Presidencia (SECULTURA) are partners in this research project to document and restore the historical and cultural value of this site.

Published
2023
Full Text
View/download PDF

37. Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology

Author

Giorgia Serena Gullotta, Donatella De Feo, Ekaterina Friebel, Aurora Semerano, Giulia Maria Scotti, Andrea Bergamaschi, Erica Butti, Elena Brambilla, Angela Genchi, Alessia Capotondo, Mattia Gallizioli, Simona Coviello, Marco Piccoli, Tiziana Vigo, Patrizia Della Valle, Paola Ronchi, Giancarlo Comi, Armando D’Angelo, Norma Maugeri, Luisa Roveri, Antonio Uccelli, Burkhard Becher, Gianvito Martino, and Marco Bacigaluppi

Subjects
Immunology, Immunology and Allergy
Published
2023
Full Text
View/download PDF

39. Patrimonio cultural material y demanda turística, cantón Latacunga, provincia de Cotopaxi

Author

Marco Vinicio Viracocha Lema, Renato Hernán Herrera Chávez, and William Marco Samaniego Erazo

Abstract

Introducción. Latacunga, es un cantón lleno de historia, tradición y cultura que enamora a propios y extraños por su riqueza patrimonial material e inmaterial, con un gran potencial del turismo cultural-patrimonial. Objetivos. El presente trabajo de investigación tiene como objetivo analizar el patrimonio cultural material y su influencia con la demanda turística. Metodología. El diseño de la investigación empleado es no experimental, transversal; de tipo documental, de campo, descriptiva y de carácter correlacional. La validación del instrumento de investigación a través de alfa de Cronbach, cuestionarios bajo la escala de Likert, la unidad de análisis de investigada fue a 40 prestadores de servicios turísticos y 276 turistas. En el software SPSS, con chi cuadrado, se comprobó las hipótesis. Resultados. Se demuestra la influencia significativa entre el patrimonio cultural material y la demanda turística. A su vez se describen y caracterizan las dimensiones relacionadas a los bienes muebles; bienes inmuebles; bienes arqueológicos; producto turístico; motivación; turistas. Conclusiones. Existe una influencia significativa entre el patrimonio cultural material y la demanda turística. Área de la ciencia. Turismo cultural.

Published
2023
Full Text
View/download PDF

40. Efficiency of Bacillus subtilis UFMT-PANT001 as a plant growth-promoting inoculant in soybean in the field

Author

Marco Antonio Camillo De Carvalho, Marco Eustáquio De Sá, Alexandre Paulo Machado, and Aloisio Freitas Chagas Junior

Abstract

Bacteria of the genus Bacillus can be considered plant growth-promoting rhizobacteria because they have the ability to colonize the rhizosphere and promote plant growth. This study aimed to demonstrate the efficiency of Bacillus subtilis UFMT-Pant001 in liquid formulation as an inoculant in promoting soybean plant growth and field yield. Four field experiments were conducted in the municipalities of Gurupi (Tocantins state), Campo Verde and Alta Floresta (Mato Grosso State), which had some distinct soil and climate characteristics, in the 2016/2017 harvest. In all experiments, for the treatments with B. subtilis UFMT-Pant001, the selected product with plant growth-promoting potential was used in liquid formulation, at a minimum concentration of 1 x 109 CFU mL-1. The inoculation of B. subtilis UFMT-Pant001 increased the biomass and yield of the different soybean cultivars under field conditions in Gurupi, Campo Verde and Alta Floresta in the 2016/16/2017 harvest. Considering the different field experiments with the doses tested, there were positive results starting at dose of 200 mL per 50 kg of seed. Thus, a dose of 200 to 300 mL of the B. subtilis UFMT-Pant001 inoculant at a concentration of 1 x 109 CFU mL-1 is recommended. The B. subtilis strain UFMT-Pant001 should be recommended as an inoculant to promote plant growth in soybean at a dose of 200 to 300 mL and a minimum concentration of 1 x 109 CFU mL-1 per 50 kg of seed.

Published
2023
Full Text
View/download PDF

46. The global contribution of soil mosses to ecosystem services

Author

David J. Eldridge, Emilio Guirado, Peter B. Reich, Raúl Ochoa-Hueso, Miguel Berdugo, Tadeo Sáez-Sandino, José L. Blanco-Pastor, Leho Tedersoo, César Plaza, Jingyi Ding, Wei Sun, Steven Mamet, Haiying Cui, Ji-Zheng He, Hang-Wei Hu, Blessing Sokoya, Sebastian Abades, Fernando Alfaro, Adebola R. Bamigboye, Felipe Bastida, Asunción de los Ríos, Jorge Durán, Juan J. Gaitan, Carlos A. Guerra, Tine Grebenc, Javier G. Illán, Yu-Rong Liu, Thulani P. Makhalanyane, Max Mallen-Cooper, Marco A. Molina-Montenegro, José L. Moreno, Tina U. Nahberger, Gabriel F. Peñaloza-Bojacá, Sergio Picó, Ana Rey, Alexandra Rodríguez, Christina Siebe, Alberto L. Teixido, Cristian Torres-Díaz, Pankaj Trivedi, Juntao Wang, Ling Wang, Jianyong Wang, Tianxue Yang, Eli Zaady, Xiaobing Zhou, Xin-Quan Zhou, Guiyao Zhou, Shengen Liu, Manuel Delgado-Baquerizo, British Ecological Society, Hermon Slade Foundation, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Junta de Andalucía, Ministry of Education Innovation Team Development Plan, Research Program in Forest Biology, Ecology and Technology, Slovenian Research Agency, National Science Foundation (US), Ministério da Ciência, Tecnologia e Ensino Superior (Portugal), European Commission, Programa de Investimento e Despesas de Desenvolvimento da Administração Central (Portugal), Eldridge, David J., Guirado, Emilio, Reich, Peter B., Ochoa-Hueso, Raúl, Berdugo, Miguel, Sáez-Sandino, Tadeo, Blanco-Pastor, José Luis, Tedersoo, Leho, Plaza de Carlos, César, Ding, Jingyi, Sun, Wei, Mamet, Steven, Cui, Haiying, He, Ji-Zheng, Hu, Hang-Wei, Abades, Sebastián, Alfaro, Fernando D., Bastida, F., Ríos, Asunción de los, Durán, Jorge, Gaitán, Juan J., Guerra, Carlos A., Grebenc, Tine, Liu, Yurong, Makhalanyane, Thulani P., Mallen-Cooper, Max, Molina-Montenegro, Marco A., Moreno, José Luis, Nahberger, Tina U., Peñaloza-Bojacá, Gabriel F., Picó, Sergio, Rey, Ana, Rodríguez-Pereiras, Alexandra, Siebe, Christina, Teixido, Alberto L., Torres-Díaz, Cristian, Trivedi, Pankaj, Wang, Jun-Tao, Wang, Jianyong, Yang, Tianxue, Zaady, Eli, Zhou, Guiyao, Liu, Shengen, Delgado-Baquerizo, Manuel, Universidad de Alicante. Instituto Multidisciplinar para el Estudio del Medio 'Ramón Margalef', and Laboratorio de Ecología de Zonas Áridas y Cambio Global (DRYLAB)

Subjects
Global distribution, Soil mosses, Ecosystem services, General Earth and Planetary Sciences, Soil biodiversity and function
Abstract

9 páginas.- 5 figuras.- 51 referencias.- Supplementary information The online version contains supplementary material available at https://doi.org/10.1038/s41561-023-01170-x, Soil mosses are among the most widely distributed organisms on land. Experiments and observations suggest that they contribute to terrestrial soil biodiversity and function, yet their ecological contribution to soil has never been assessed globally under natural conditions. Here we conducted the most comprehensive global standardized field study to quantify how soil mosses influence 8 ecosystem services associated with 24 soil biodiversity and functional attributes across wide environmental gradients from all continents. We found that soil mosses are associated with greater carbon sequestration, pool sizes for key nutrients and organic matter decomposition rates but a lower proportion of soil-borne plant pathogens than unvegetated soils. Mosses are especially important for supporting multiple ecosystem services where vascular-plant cover is low. Globally, soil mosses potentially support 6.43 Gt more carbon in the soil layer than do bare soils. The amount of soil carbon associated with mosses is up to six times the annual global carbon emissions from any altered land use globally. The largest positive contribution of mosses to soils occurs under a high cover of mat and turf mosses, in less-productive ecosystems and on sandy and salty soils. Our results highlight the contribution of mosses to soil life and functions and the need to conserve these important organisms to support healthy soils., The study work associated with this paper was funded by a Large Research Grant from the British Ecological Society (no. LRB17\1019; MUSGONET). D.J.E. is supported by the Hermon Slade Foundation. M.D.-B. was supported by a Ramón y Cajal grant from the Spanish Ministry of Science and Innovation (RYC2018-025483-I), a project from the Spanish Ministry of Science and Innovation for the I + D + i (PID2020-115813RA-I00 funded by MCIN/AEI/10.13039/501100011033a) and a project PAIDI 2020 from the Junta de Andalucía (P20_00879). E.G. is supported by the European Research Council grant agreement 647038 (BIODESERT). M.B. is supported by a Ramón y Cajal grant from Spanish Ministry of Science (RYC2021-031797-I). A.d.l.R is supported by the AEI project PID2019-105469RB-C22. L.W. and Jianyong Wang are supported by the Program for Introducing Talents to Universities (B16011) and the Ministry of Education Innovation Team Development Plan (2013-373). The contributions of T.G. and T.U.N. were supported by the Research Program in Forest Biology, Ecology and Technology (P4-0107) and the research projects J4-3098 and J4-4547 of the Slovenian Research Agency. The contribution of P.B.R. was supported by the NSF Biological Integration Institutes grant DBI-2021898. J. Durán and A. Rodríguez acknowledge support from the FCT (2020.03670.CEECIND and SFRH/BDP/108913/2015, respectively), as well as from the MCTES, FSE, UE and the CFE (UIDB/04004/2021) research unit financed by FCT/MCTES through national funds (PIDDAC).

Published
2023
Full Text
View/download PDF

47. Safety and efficacy of zilucoplan in patients with generalised myasthenia gravis (RAISE): a randomised, double-blind, placebo-controlled, phase 3 study

Author

James F Howard, Saskia Bresch, Angela Genge, Channa Hewamadduma, John Hinton, Yessar Hussain, Raul Juntas-Morales, Henry J Kaminski, Angelina Maniaol, Renato Mantegazza, Masayuki Masuda, Kumaraswamy Sivakumar, Marek Śmiłowski, Kimiaki Utsugisawa, Tuan Vu, Michael D Weiss, Małgorzata Zajda, Babak Boroojerdi, Melissa Brock, Guillemette de la Borderie, Petra W Duda, Romana Lowcock, Mark Vanderkelen, M Isabel Leite, Dylan Sembinelli, Jeanne Teitelbaum, Michael Nicolle, Emilien Bernard, Juliette Svahn, Marco Spinazzi, Tanya Stojkovic, Sophie Demeret, Nicolas Weiss, Loïc Le Guennec, Sihame Messai, Christine Tranchant, Aleksandra Nadaj-Pakleza, Jean-Baptiste Chanson, Muhtadi Suliman, Leila Zaidi, Celine Tard, Peggy Lecointe, Jana Zschüntzsch, Jens Schmidt, Stefanie Glaubitz, Rachel Zeng, Matthias Scholl, Markus Kowarik, Ulf Ziemann, Markus Krumbholz, Pascal Martin, Christoph Ruschil, Jutta Dünschede, Roswitha Kemmner, Natalie Rumpel, Benjamin Berger, Andreas Totzeck, Tim Hagenacker, Benjamin Stolte, Raffaele Iorio, Amelia Evoli, Silvia Falso, Carlo Antozzi, Rita Frangiamore, Fiammetta Vanoli, Elena Rinaldi, Kazushi Deguchi, Naoya Minami, Yuriko Nagane, Yasushi Suzuki, Sayaka Ishida, Shigeaki Suzuki, Jin Nakahara, Astushi Nagaoka, Shunsuke Yoshimura, Shingo Konno, Youko Tsuya, Akiyuki Uzawa, Tomoya Kubota, Masanori Takahashi, Tatsusada Okuno, Hiroyuki Murai, Nils Erik Gilhus, Marion Boldingh, Tone Hakvåg Rønning, Urszula Chyrchel-Paszkiewicz, Klaudiusz Kumor, Tomasz Zielinski, Krzysztof Banaszkiewicz, Michał Błaż, Agata Kłósek, Mariola Świderek-Matysiak, Andrzej Szczudlik, Aneta Paśko, Lech Szczechowski, Marta Banach, Jan Ilkowski, Solange Kapetanovic Garcia, Patricia Ortiz Bagan, Ana Belén Cánovas Segura, Joana Turon Sans, Nuria Vidal Fernandez, Elena Cortes Vicente, Patricia Rodrigo Armenteros, Mohammad Ashraghi, Ana Cavey, Liam Haslam, Anna Emery, Kore Liow, Sharon Yegiaian, Alexandru Barboi, Rosa Maria Vazquez, Joshua Lennon, Robert M Pascuzzi, Cynthia Bodkin, Sandra Guingrich, Adam Comer, Mark Bromberg, Teresa Janecki, Sami Saba, Marco Tellez, Bakri Elsheikh, Miriam Freimer, Sarah Heintzman, Raghav Govindarajan, Jeffrey Guptill, Janice M Massey, Vern Juel, Natalia Gonzalez, Ali A Habib, Tahseen Mozaffar, Manisha Korb, Namita Goyal, Hannah Machemehl, Georgios Manousakis, Jeffrey Allen, Emily Harper, Constantine Farmakidis, Lilli Saavedra, Mazen Dimachkie, Mamatha Pasnoor, Salma Akhter, Said Beydoun, Courtney McIlduff, Joan Nye, Bhaskar Roy, Bailey Munro Sheldon, Richard Nowak, Benjamin Barnes, Michael Rivner, Niraja Suresh, Jessica Shaw, Brittany Harvey, Lucy Lam, Nikki Thomas, Manisha Chopra, Rebecca E Traub, Sarah Jones, Mary Wagoner, Sejla Smajic, Radwa Aly, Jonathan Katz, Henry Chen, Robert G Miller, Liberty Jenkins, Shaida Khan, Bhupendra Khatri, Lisa Sershon, Pantelis Pavlakis, Shara Holzberg, Yuebing Li, Irys B Caristo, Robert Marquardt, Debbie Hastings, Jacob Rube, Robert P Lisak, Aparna Choudhury, Katherine Ruzhansky, Amit Sachdev, Susan Shin, Joan Bratton, Mary Fetter, Naya McKinnon, Jonathan McKinnon, Laura Sissons-Ross, Amos Sahu, and B Jane Distad

Subjects
Neurology (clinical)
Published
2023
Full Text
View/download PDF

48. Improving the Performance of HPHT-Diamond Detectors for Pulsed X-Ray Dosimetry Using the Synchronous Detection Technique

Author

Stefano Salvatori, Sara Pettinato, Marco Girolami, Daniele Maria Trucchi, Maria Cristina Rossi, Salvatori, Stefano, Pettinato, Sara, Girolami, Marco, Maria Trucchi, Daniele, and Rossi, Maria Cristina

Subjects
HPHT-diamond, gated-integrator, LINAC, X-ray detectors, Radiation Therapy, Electrical and Electronic Engineering, Electronic, Optical and Magnetic Materials
Abstract

A single-crystal diamond sample grown by highpressure high temperature (HPHT) technique was used for the fabrication of a metal-semiconductor-metal photoconductor. The sample quality was evaluated by means of spectral photocurrent measurements highlighting the presence of a significant density of defect states within the diamond bandgap, responsible for trapmediated conduction mechanisms. The photoconductor was fully characterized under 6 MeV pulsed X-rays, sourced by a medical linear accelerator, in the 0.05 – 10 Gy and 1 – 6 Gy/min dose and dose-rate ranges, respectively. Photocurrent measurements performed with a conventional precision electrometer showed that the detector performance is strongly affected by charge-trapping phenomena, resulting in a sub-linear dependence with the doserate (power-law dependence with an exponent of 0.86). Measurements were repeated in the same experimental conditions by coupling the detector to a specifically developed gatedintegrator, allowing for a synchronous integration of photocurrent pulses (limited to 40 μs) centered on each impinging X-ray pulse. In this case, the detector photoresponse showed an excellent linearity with both the dose and the dose-rate (power-law dependence with 1.0009 ± 0.0004 and 1.009 ± 0.005 exponents, respectively). Significantly, the proposed synchronous integration technique is then able to mitigate the detrimental effect that defects have on detector performance. The proposed method paves therefore the way to the exploitation of HPHT-diamond as a lowcost alternative to single-crystal CVD-diamond for the fabrication of accurate and linear X-ray dosimeters.

Published
2023
Full Text
View/download PDF

49. Somatic Double Inactivation of NF1 Associated with NF1-Related Pectus Excavatum Deformity

Author

Cristina Chelleri, Marcello Scala, Patrizia De Marco, Vittorio Guerriero, Marzia Ognibene, Francesca Madia, Sara Guerrisi, Marco Di Duca, Michele Torre, Serena Tamburro, Paolo Scudieri, Gianluca Piccolo, Girolamo Mattioli, Francesca Buffelli, Paolo Uva, Diego Vozzi, Ezio Fulcheri, Pasquale Striano, Maria Cristina Diana, and Federico Zara

Subjects
Article Subject, Genetics, Genetics (clinical)
Abstract

Neurofibromatosis type 1 (NF1) is a neurocutaneous genetic disorder with a broad spectrum of associated signs and symptoms, including skeletal anomalies. The association of NF1 with anterior chest wall deformities has been recently reported, especially the pectus excavatum (PE). Over the years, several authors have suggested loss of heterozygosity (LOH) as the possible pathogenic mechanism underlying the development of the typical NF1 skeletal features. Here, we report a NF1 patient with severe chest deformity and harboring the germline heterozygous pathogenic NF1 variant NM_001042492.3: c.4271delC p.(Ala1424Glufs ∗ 4). Through next-generation sequencing (NGS), we investigated the affected cartilage from the PE deformity and identified the additional frameshift variant NM_001042492.3: c.2953delC p.(Gln985Lysfs ∗ 7), occurring as a somatic NF1 second hit mutation. Exome sequencing confirmed the absence of additional variants of potential pathogenic relevance. Western blot analysis showed the absence of wild-type NF1 protein in the cartilage of the patient, consistent with a somatic double inactivation (SDI) of NF1. Taken together, our findings support the role of SDI in NF1-related PE, widening the spectrum of the pathophysiological mechanisms involved in NF1-related skeletal features.

Published
2023
Full Text
View/download PDF

50. Complex Thinking and Its Relevance in Professional Training: An Approach to Engineering Students in a Mexican University

Author

Marco Cruz-Sandoval, José Carlos Vázquez-Parra, Martina Carlos-Arroyo, and Marco Vinicio Del Angel-González

Subjects
General Engineering, Education
Abstract

This article aims to present the results of an analysis of the level of perceived achievement of the complex thinking competency among a group of engineering students in their last semester at a university in Western Mexico. The intention is to identify whether this population has the necessary skills to meet challenges and solve problems related to the demands of their future professional environments. Specifically, we not only seek to know the level of perception of achievement of complex thinking but also to understand its behavior and the possible existence of differences between the male and female populations. Methodologically, exploratory and multivariate descriptive statistical analyses were carried out. The results showed that the participants felt a high level of perceived achievement of the complex thinking competency, which was more noticeable in the male population.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results