11 results on '"Marckenley Isaac"'
Search Results
2. Author response for 'Effect of Vitamin <scp> D 3 </scp> Supplementation on Acute Fracture Healing: A Phase <scp>II</scp> Screening Randomized <scp>Double‐Blind</scp> Controlled Trial'
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null Gerard P. Slobogean, null Sofia Bzovsky, null Nathan N. O'Hara, null Lucas S. Marchand, null Zachary D. Hannan, null Haley K. Demyanovich, null Daniel W. Connelly, null Jonathan D. Adachi, null Lehana Thabane, null Sheila Sprague, null Mohit Bhandari, null Michael F. Holick, null Nicole Simunovic, null Kim Madden, null Taryn Scott, null Andrew Duong, null Diane Heels‐Ansdell, null Joshua Rudnicki, null Andrew N. Pollak, null Robert V. O'Toole, null Christopher LeBrun, null Jason W. Nascone, null Marcus F. Sciadini, null Yasmin Degani, null Raymond Pensy, null Theodore Manson, null W. Andrew Eglseder, null Christopher G. Langhammer, null Aaron J. Johnson, null Haley Demyanovich, null Andrea Howe, null Dimitrius Marinos, null Daniel Mascarenhas, null George Reahl, null Katherine Ordonio, null Marckenley Isaac, null Ugochukwu Udogwu, null Mitchell Baker, null Alexandra Mulliken, null Jared Atchison, null Michael G. Schloss, null Syed M. R. Zaidi, null Phillip C. McKegg, null Genaro A. DeLeon, null Qasim M. Ghulam, null Megan Camara, and null the Vita‐Shock Investigators
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- 2022
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3. Does an Implant Usage Report Card Impact Orthopaedic Trauma Implant Stewardship?
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Theodore T. Manson, Nathan N OʼHara, Mitchell Baker, Christopher T. LeBrun, Jason W. Nascone, Patrick Mixa, Robert V OʼToole, Marckenley Isaac, Marcus F. Sciadini, Gerard P. Slobogean, Kanu Okike, Andrew N. Pollak, and John Morellato
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Male ,Scrutiny ,Cost-Benefit Analysis ,Bone Nails ,Fracture Fixation, Internal ,Fractures, Bone ,03 medical and health sciences ,0302 clinical medicine ,Trauma Centers ,Cost Savings ,Task Performance and Analysis ,Humans ,Medicine ,Orthopedics and Sports Medicine ,Orthopaedic trauma ,Retrospective Studies ,030222 orthopedics ,business.industry ,030208 emergency & critical care medicine ,General Medicine ,Middle Aged ,medicine.disease ,United States ,Fracture Fixation, Intramedullary ,Female ,Surgery ,Stewardship ,Implant ,Medical emergency ,business ,Bone Plates ,Report card - Abstract
As hospitals seek to control variable expenses, orthopaedic surgeons have come under scrutiny because of relatively high implant costs. We aimed to determine whether feedback to surgeons regarding implant costs results in changes in implant selection.This study was undertaken at a statewide trauma referral center and included 6 fellowship-trained orthopaedic trauma surgeons. A previously implemented implant stewardship program at our institution using a "red-yellow-green" (RYG) implant selection tool classifies 7 commonly used trauma implant constructs based on cost and categorizes each implant as red (used for patient-specific requirements, most expensive), yellow (midrange), and green (preferred vendor, least expensive). The constructs included were femoral intramedullary nail, tibial intramedullary nail, long and short cephalomedullary nails, distal femoral plate, proximal tibial plate, and lower-limb external fixator. Baseline implant usage from the previous year was obtained and provided to each surgeon. Each surgeon received a monthly feedback report containing individual implant utilization and overall ranking.The overall RYG score increased from 68.7 to 79.1 of 100 (P0.001). Three of the 7 implants (tibial and femoral nails and lower-limb external fixation) had significant increases in their RYG scores; implant selections for the other 4 implants were not significantly altered. A decrease of 1.8% (95% confidence interval, 0.4-3.2, P = 0.01) was noted in overall implant costs over the study period.Our intervention resulted in changes in surgeons' implant selections and cost savings. However, surgeons were unwilling to change certain implants despite their being more expensive.
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- 2019
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4. Not All Garden-I and II Femoral Neck Fractures in the Elderly Should Be Fixed
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Mohit Bhandari, Faith Investigators, Marc F. Swiontkowski, Ugochukwu N. Udogwu, Gerard P. Slobogean, Sheila Sprague, Marckenley Isaac, and Kanu Okike
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Male ,Reoperation ,Scientific Articles ,medicine.medical_specialty ,Standard of care ,Radiography ,medicine.medical_treatment ,Femoral Neck Fractures ,Fracture Fixation, Internal ,03 medical and health sciences ,Age Distribution ,0302 clinical medicine ,Fracture fixation ,medicine ,Humans ,Internal fixation ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,Sex Distribution ,Aged ,Aged, 80 and over ,030222 orthopedics ,business.industry ,social sciences ,General Medicine ,Middle Aged ,Arthroplasty ,Prosthesis Failure ,Surgery ,Multicenter study ,Female ,business ,Tilt (camera) - Abstract
Internal fixation is currently the standard of care for Garden-I and II femoral neck fractures in elderly patients. However, there may be a degree of posterior tilt (measured on preoperative lateral radiograph) above which failure is likely, and primary arthroplasty would be preferred. The purpose of this analysis was to determine the association between posterior tilt and the risk of subsequent arthroplasty following internal fixation of Garden-I and II femoral neck fractures in elderly patients. METHODS: This study is a preplanned secondary analysis of data collected in the FAITH (Fixation using Alternative Implants for the Treatment of Hip fractures) trial, an international, multicenter, randomized controlled trial comparing the sliding hip screw with cannulated screws in the treatment of femoral neck fractures in patients ≥50 years old. For each patient who sustained a Garden-I or II femoral neck fracture and had an adequate preoperative lateral radiograph, the amount of posterior tilt was categorized as
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- 2019
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5. Revealing the Biases Within
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Marckenley Isaac, Olga E. Paniagua, and Bryan P. Mahoney
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General Engineering ,General Earth and Planetary Sciences ,General Environmental Science - Published
- 2021
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6. Incidence of Knee Pain Beyond 1 Year: Suprapatellar Versus Infrapatellar Approach for Intramedullary Nailing of the Tibia
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Christopher T. LeBrun, Mitchell Baker, Theodore T. Manson, Daniel Connelly, Nathan N OʼHara, Marckenley Isaac, Ugo Udogwu, Robert V OʼToole, Mauri Zomar, and Gerard P. Slobogean
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Adolescent ,Tibia Fracture ,Bone Nails ,law.invention ,Intramedullary rod ,Cohort Studies ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Postoperative Complications ,law ,Fracture fixation ,medicine ,Humans ,Orthopedics and Sports Medicine ,Tibia ,Aged ,Pain Measurement ,Retrospective Studies ,Aged, 80 and over ,030222 orthopedics ,business.industry ,Incidence ,Kneeling ,030208 emergency & critical care medicine ,Retrospective cohort study ,General Medicine ,Patella ,Middle Aged ,Arthralgia ,Surgery ,Fracture Fixation, Intramedullary ,Tibial Fractures ,Knee pain ,Female ,medicine.symptom ,business ,Cohort study ,Follow-Up Studies - Abstract
Objective To compare the magnitude of knee pain between the suprapatellar (SP) and infrapatellar (IP) approach for tibial nailing in patients who are more than 1 year after injury. Design Retrospective cohort study. Setting Academic Level I trauma center. Patients/participants All tibia fracture patients 18-80 years of age treated with an intramedullary tibial nail during a 5-year period were retrospectively reviewed for inclusion. The surgical approach was determined by surgeon preference, with 3 of the 9 surgeons routinely using the SP approach. The primary outcome was knee pain during kneeling, with secondary assessments comparing knee pain during resting, walking, and the past 24 hours. Intervention Intramedullary nailing of a tibia fracture with either the SP or IP approach. Main outcome measurements Knee pain assessed with the Numeric Rating Scale between 0 and 10. A difference of >1.0 was considered to be clinically meaningful. Results The study group consisted of 262 patients (SP, n = 91; IP, n = 171) with a mean age of 41.4 years (SD = 16.6). The median follow-up was 3.8 years (range: 1.5-7.0). No difference in knee pain during kneeling was detected between the surgical approaches (IP: 3.9, SP 3.8; P = 0.90; mean difference: -0.06, 95% confidence interval, -1 to 0.9). Similarly, no differences were detected in average knee pain scores at rest (IP: 2.0, SP: 2.0; P = 1.00), walking (IP: 2.7, SP 3.0; P = 0.51), or the last 24 hours (IP: 2.6, SP 2.9; P = 0.45). Conclusions In contrast to a study conducted by Sun et al, in which there was a statistical difference in knee pain between the SP and IP surgical approaches, we did not detect any statistical or clinical differences in knee pain between the SP and IP surgical approaches among patients with greater than 12 months of follow-up. Level of evidence Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
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- 2019
7. A patient-centered composite endpoint weighting technique for orthopaedic trauma research
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Nathan N O'Hara, Marckenley Isaac, Renan C. Castillo, Katherine Frey, Ugochukwu N. Udogwu, Andrea Howe, Mitchell Baker, Daniel Connelly, Gerard P. Slobogean, Robert V O'Toole, and Dimitrius Marinos
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Adult ,Male ,medicine.medical_specialty ,Epidemiology ,Patient-centered care ,Orthopaedic trauma ,Health Informatics ,Composite endpoint ,030204 cardiovascular system & hematology ,03 medical and health sciences ,Fractures, Bone ,0302 clinical medicine ,Fracture Fixation ,Outcome Assessment, Health Care ,Severe pain ,Medicine ,Humans ,030212 general & internal medicine ,Above knee amputation ,Below knee amputation ,lcsh:R5-920 ,Weighting technique ,business.industry ,Study design ,Middle Aged ,Best-worst scaling choice experiment ,Outcome (probability) ,Weighting ,Fracture ,Research Design ,Physical therapy ,Female ,Health Services Research ,business ,lcsh:Medicine (General) ,Surgical site infection ,Patient centered ,Research Article - Abstract
Background This study aimed to address the current limitations of the use of composite endpoints in orthopaedic trauma research by quantifying the relative importance of clinical outcomes common to orthopaedic trauma patients and use those values to develop a patient-centered composite endpoint weighting technique. Methods A Best-Worst Scaling choice experiment was administered to 396 adult surgically-treated fracture patients. Respondents were presented with ten choice sets, each consisting of three out of ten plausible clinical outcomes. Hierarchical Bayesian modeling was used to determine the utilities associated with the outcomes. Results Death was the outcome of greatest importance (mean utility = − 8.91), followed by above knee amputation (− 7.66), below knee amputation (− 6.97), severe pain (− 5.90), deep surgical site infection (SSI) (− 5.69), bone healing complications (− 5.20), and moderate pain (− 4.59). Mild pain (− 3.30) and superficial SSI (− 3.29), on the other hand, were the outcomes of least importance to respondents. Conclusion This study revealed that patients’ relative importance towards clinical outcomes followed a logical gradient, with distinct and quantifiable preferences for each possible component outcome. These findings were incorporated into a novel composite endpoint weighting technique.
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- 2019
8. MOESM2 of A patient-centered composite endpoint weighting technique for orthopaedic trauma research
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Ugochukwu Udogwu, Howe, Andrea, Frey, Katherine, Marckenley Isaac, Connelly, Daniel, Dimitrius Marinos, Baker, Mitchell, Castillo, Renan, Slobogean, Gerard, O’Toole, Robert, and O’Hara, Nathan
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Additional file 2. Data for hypothetical pilon fracture trial available in long and wide format.
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- 2019
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9. MOESM3 of A patient-centered composite endpoint weighting technique for orthopaedic trauma research
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Ugochukwu Udogwu, Howe, Andrea, Frey, Katherine, Marckenley Isaac, Connelly, Daniel, Dimitrius Marinos, Baker, Mitchell, Castillo, Renan, Slobogean, Gerard, O’Toole, Robert, and O’Hara, Nathan
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Additional file 3. Plausible unweighted and weighted methods of analyses for counts, time to event, and multivariate analysis.
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- 2019
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10. The socioeconomic impact of orthopaedic trauma: A systematic review and meta-analysis
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Gerard P. Slobogean, Nathan N O'Hara, Niek S. Klazinga, and Marckenley Isaac
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Male ,Critical Care and Emergency Medicine ,Economics ,Social Sciences ,Poison control ,Database and Informatics Methods ,Fractures, Bone ,Mathematical and Statistical Techniques ,0302 clinical medicine ,Outcome Assessment, Health Care ,Medicine and Health Sciences ,Medicine ,Public and Occupational Health ,Prospective Studies ,030212 general & internal medicine ,Database Searching ,Prospective cohort study ,Trauma Medicine ,030222 orthopedics ,Multidisciplinary ,Statistics ,Metaanalysis ,Research Assessment ,Middle Aged ,Socioeconomic Aspects of Health ,Systematic review ,Research Design ,Meta-analysis ,Physical Sciences ,Research Reporting Guidelines ,Income ,Absenteeism ,Population study ,Female ,Traumatic Injury ,Research Article ,Employment ,Adult ,Systematic Reviews ,Adolescent ,Science ,Research and Analysis Methods ,Young Adult ,03 medical and health sciences ,Injury prevention ,Humans ,Statistical Methods ,Socioeconomic status ,Aged ,business.industry ,Health Care ,Orthopedics ,Social Class ,Labor Economics ,business ,Mathematics ,Demography - Abstract
The overall objective of this study was to determine the patient-level socioeconomic impact resulting from orthopaedic trauma in the available literature. The MEDLINE, Embase, and Scopus databases were searched in December 2019. Studies were eligible for inclusion if more than 75% of the study population sustained an appendicular fracture due to an acute trauma, the mean age was 18 through 65 years, and the study included a socioeconomic outcome, defined as a measure of income, employment status, or educational status. Two independent reviewers performed data extraction and quality assessment. Pooled estimates of the socioeconomic outcome measures were calculated using random-effects models with inverse variance weighting. Two-hundred-five studies met the eligibility criteria. These studies utilized five different socioeconomic outcomes, including return to work (n = 119), absenteeism days from work (n = 104), productivity loss (n = 11), income loss (n = 11), and new unemployment (n = 10). Pooled estimates for return to work remained relatively consistent across the 6-, 12-, and 24-month timepoint estimates of 58.7%, 67.7%, and 60.9%, respectively. The pooled estimate for mean days absent from work was 102.3 days (95% CI: 94.8-109.8). Thirteen-percent had lost employment at one-year post-injury (95% CI: 4.8-30.7). Tremendous heterogeneity (I2>89%) was observed for all pooled socioeconomic outcomes. These results suggest that orthopaedic injury can have a substantial impact on the patient's socioeconomic well-being, which may negatively affect a person's psychological wellbeing and happiness. However, socioeconomic recovery following injury can be very nuanced, and using only a single socioeconomic outcome yields inherent bias. Informative and accurate socioeconomic outcome assessment requires a multifaceted approach and further standardization.
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- 2020
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11. Implementation of a Perioperative Cardiac Risk Stratification Protocol Is Associated with Improved Adherence with American Heart Association Guidelines in Geriatric Orthopedic Trauma Patients
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Jake Johnson, Robert V O'Toole, Marckenley Isaac, Ugo Udogwu, Marcus F. Sciadini, Deborah M. Stein, and Bryce E. Haac
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Protocol (science) ,medicine.medical_specialty ,Orthopedic trauma ,business.industry ,Emergency medicine ,medicine ,Surgery ,Perioperative ,Cardiac risk ,business ,Stratification (mathematics) - Published
- 2019
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