Search

Your search keyword '"Marchesini E"' showing total 30 results
Start Over Author "Marchesini E" Language undetermined
30 results on '"Marchesini E"'

1. ASTENA: A mission concept for a deep study of the transient gamma-ray sky and for nuclear astrophysics

Author

Virgilli, E., Frontera, F., Rosati, P., Guidorzi, C., Ferro, L., Moita, M., Orlandini, M., Fuschino, F., Campana, R., Labanti, C., Marchesini, E., Caroli, E., Auricchio, N., Stephen, J. B., Ferrari, C., Squerzanti, S., Del Sordo, S., Gargano, C., and Pucci, M.

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), FOS: Physical sciences, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Instrumentation and Methods for Astrophysics (astro-ph.IM)
Abstract

Gamma-ray astronomy is a branch whose potential has not yet been fully exploited. The observations of elemental and isotopic abundances in supernova (SN) explosions are key probes not only of the stellar structure and evolution but also for understanding the physics that makes Type-Ia SNe as standard candles for the study of the Universe expansion properties. In spite of its crucial role, nuclear astrophysics remains a poorly explored field mainly for the typical emission lines intensity which are vanishing small and requires very high sensitivities of the telescopes. Furthermore, in spite that the Galactic bulge-dominated intensity of positron annihilation line at 511 keV has been measured, its origin is still a mystery due to the poor angular resolution and insufficient sensitivity of the commonly employed instrumentation in the sub-MeV energy domain. To answer these scientific issues a jump in sensitivity and angular resolution with respect to the present instrumentation is required. Conceived within the EU project AHEAD, a new high energy mission, capable of tackling the previously mentioned topics, has been proposed. This concept of mission named ASTENA (Advanced Surveyor of Transient Events and Nuclear Astrophysics), includes two instruments: a Wide Field Monitor with Imaging and Spectroscopic (WFM-IS, 2 keV - 20 MeV) capabilities and a Narrow Field Telescope (NFT, 50 - 700 keV). Thanks to the combination of angular resolution, sensitivity and large FoV, ASTENA will be a breakthrough in the hard X and soft gamma--ray energy band, also enabling polarimetry in this energy band. In this talk the science goals of the mission are discussed, the payload configuration is described and expected performances in observing key targets are shown., Comment: 17 pages, 7 figures, sixteenth Marcel Grossmann Meeting - Conference Proceedings

Published
2023
Full Text
View/download PDF

2. Model-informed precision dosing of levetiracetam in pediatrics population

Author

Bonan R, Caleffi-Marchesini E, Kimura E, Pereira L, Frederico Severino Martins, Lima P, Andréa Diniz, and Macente J

Subjects
education.field_of_study, Pediatrics, medicine.medical_specialty, business.industry, Population, medicine, Dosing, Levetiracetam, education, business, medicine.drug
Abstract

Aims: Assessing the suitability and safety of doses of levetiracetam in pediatrics using physiologic-based pharmacokinetic (PBPK) modeling. Methods: A PBPK model of levetiracetam was developed and validated for healthy adults and scaled for children (0.5 to 12 years old). Prediction of levetiracetam exposure at steady- state, were carried out for different therapeutic regimens to achieve the target of Cmax values within the therapeutic range of 5 to 46 µg ml-1. Then, a multivariate linear regression analysis (MLR) was applied to correlate the simulated data with covariates: dose, therapeutic regimen, sex, age and body weight (BW), to describe the best model prediction for the initial dosing in pediatrics. Results: The results indicated the suitability of the PBPK model for adults and pediatrics. For children aged 0.5 to 6 y.o. the dose range capable of reaching the pharmacokinetic target is between 10 and 100 mg kg-1 day-1, for 7 to 9 y.o. doses between 20 and 90 mg kg-1 day-1, and for 10 to 12 y.o. doses between 20 to 80 mg kg-1 day-1. Further, the MLR related Cmax to dose, therapeutic regimen, and BW. Conclusions: For 3 daily administrations, it is suggested that maximum daily doses of 80 mg kg-1 could be used for ages between 0.5 and 6 y.o. and 100 mg kg-1 for ages above 7 years old, since they weigh below 50 kg. The PBPK model lumped to MLR could be very supportive for clinical decisions to safety and effectiveness of prescription of levetiracetam along the titration phase.

Published
2021
Full Text
View/download PDF

3. The $��$-ray sky seen at X-ray energies II: the Swift hunt of Fermi BL Lac objects among unidentified gamma-ray sources

Author

Marchesini, E. J., Paggi, A., Massaro, F., Masetti, N., D'Abrusco, R., and Andruchow, I.

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics
Abstract

Nearly 50% of all sources detected by the Fermi Large Area Telescope are classified as blazars or blazar candidates, one of the most elusive classes of active galaxies. Additional blazars can also be hidden within the sample of unidentified or unassociated $��$-ray sources (UGSs) that constitute about one-third of all gamma-ray sources detected to date. We recently confirmed that the large majority of Fermi blazars of the BL Lac subclass have an X-ray counterpart. Using the X-ray properties of a BL Lac training set and combining these with archival multifrequency information, we aim to search for UGSs that could have a BL Lac source within their $��$-ray positional uncertainty regions. We reduced and analyzed the Swift X-ray observations of a selected sample of 327 UGSs. We then compared the X-ray fluxes and hardness ratios of all sources detected in the pointed fields with those of known Fermi BL Lacs. We find at least one X-ray source, lying within the $��$-ray positional uncertainty at 95% confidence level, for 223 UGSs and a total of 464 X-ray sources in all fields analyzed. The X-ray properties of a large fraction of them, eventually combined with radio, infrared, and optical information, exhibit BL Lac multi-frequency behavior, thus allowing us to select high-confidence BL Lac candidates; some of them were recently observed during our optical spectroscopic campaign which confirmed their nature. We find that out of 50 X-ray sources that were confirmed as BL Lacs through optical spectroscopy, 12 do not show canonical mid-infrared or radio BL Lac properties. This indicates that the selection of X-ray BL Lac candidates is a strong method to find new counterparts within Fermi UGSs. Finally, we pinpoint a sample of 32 Swift/XRT candidate counterparts to Fermi UGSs that are most likely BL Lac objects., Published version

Published
2020
Full Text
View/download PDF

4. Use of non-steroidal anti-inflammatory drugs and analgesics in a cohort of hospitalized elderly patients: Results from the REPOSI study

Author

Pasina, L, Cortesi, L, Tettamanti, M, Nobili, A, Mannucci, Pm, Franchi, F, Salerno, F, Corrao, S, Marengoni, A, Licata, G, Violi, F, Corazza, Gr, Marcucci, M, Prisco, D, Silvestri, E, Cenci, C, Emmi, G, Biolo, G, Guarnieri, G, Zanetti, M, Fernandes, G, Vanoli, M, Grignani, G, Casella, G, Bernardi, M, Li Bassi, S, Santi, L, Zaccherini, G, Mannarino, E, Lupattelli, G, Bianconi, V, Paciullo, F, Nuti, R, Valenti, R, Ruvio, R, Cappelli, S, Palazzuoli, A, Salvatore, T, Sasso, Fc, Girelli, G, Olivieri, O, Matteazzi, T, Barbagallo, M, Plances, L, Alcamo, R, Calvo, G, Valenti, V, Zoli, M, Arnò, A, Laghi Pasini, F, Capecchi, Pl, Bicchi, M, Palasciano, P, Modeo, Me, Peragine, M, Pappagallo, F, Pugliese, S, Di Gennaro, C, Postiglione, A, Barbella, Mr, De Stefano, F, Cappellini, Md, Fabio, G, Seghezzi, S, Migone De Amicis, M, Mari, D, Dionigi Rossi, P, Damanti, S, Brignolo Ottolini, B, Miceli, M, Lenti, Mv, Padula, D, Murialdo, G, Marra, A, Cattaneo, F, Secchi, Mb, Ghelfi, D, Anastasio, A, Sofia, L, Carbone, M, Davì, G, Guagnano, Mt, Sestili, S, Mancuso, G, Calipari, D, Bartone, M, Meroni, Mr, Cavallo Perin, P, Lorenzati, B, Gruden, G, Bruno, G, Amione, C, Fornengo, P, Tassara, T, Melis, D, Rebella, L, Delitala, D, Pretti, V, Masala, Ms, Bolondi, L, Rasciti, L, Serio, I, Rossi Fanelli, F, Amoroso, A, Molfino, A, Petrillo, E, Zuccalà, G, Franceschi, F, De Marco, G, Cordischi, C, Sabbatini, M, Romanelli, G, Amolini, C, Chiesa, D, Picardi, A, Vespasiani Gentilucci, U, Gallo, P, Annoni, G, Corsi, M, Zazzetta, S, Bellelli, G, Arturi, F, Succurro, E, Rubino, M, Sesti, G, Loria, P, Becchi, Ma, Martucci, G, Fantuzzi, A, Maurantonio, M, Delitala, G, Carta, S, Atzori, S, Serra, Mg, Bleve, Ma, Gasbarrone, L, Sajeva, Mr, Brucato, A, Ghidoni, S, Di Corato, P, Agnelli, G, Marchesini, E, Fabris, F, Carlon, M, Turatto, F, Baritusso, A, Manfredini, Roberto, Molino, C, Pala, M, Fabbian, Fabio, Boari, B, De Giorgi, A, Paolisso, G, Rizzo, Mr, Laieta, Mt, Rini, G, Mansueto, P, Pepe, I, Borghi, C, Strocchi, E, De Sando, V, Sabbà, C, Vella, Fs, Suppressa, P, Valerio, R, Capobianco, C, Fenoglio, L, Bracco, C, Giraudo, Av, Testa, E, Serraino, C, Fargion, S, Bonara, P, Periti, G, Porzio, M, Peyvandi, F, Tedeschi, A, Rossio, R, Monzani, V, Savojardo, V, Folli, C, Magnini, M, Conca, A, Gobbo, G, Balduini, Cl, Bertolino, G, Provini, S, Quaglia, F, Dallegri, F, Ottonello, L, Liberale, L, Chin, Ws, Carassale, L, Caporotundo, S, Traisci, G, De Feudis, L, Di Carlo, S, Liberato, Nl, Buratti, A, Tiziana Tognin, T, Bianchi, Gb, Giaquinto, S, Purrello, F, Di Pino, A, Piro, S, Rozzini, R, Falanga, L, Montrucchio, G, Greco, E, Tizzani, P, Petitti, P, Perciccante, A, Coralli, A, Salmi, R, Gaudenzi, P, Gamberini, S, Semplicini, A, Gottardo, L, Vendemiale, G, Serviddio, G, Forlano, R, Masala, C, Mammarella, A, Raparelli, V, Basili, S, Ludovica Perri, P, Landolfi, R, Montalto, M, Mirijello, A, Vallone, C, Bellusci, M, Setti, D, Pedrazzoli, F, Guasti, L, Castiglioni, L, Maresca, A, Squizzato, A, Molaro, M, Bertolotti, M, Mussi, C, Libbra, Mv, Miceli, A, Pellegrini, E, Carulli, L, Perticone, F, Sciacqua, A, Quero, M, Bagnato, C, Corinaldesi, R, DE GIORGIO, Roberto, Serra, M, Grasso, V, Ruggeri, E, Salvi, A, Leonardi, R, Grassini, C, Mascherona, I, Minelli, G, Maltese, F, Gabrielli, A, Mattioli, M, Capeci, W, Martino, Gp, Messina, S, Ghio, R, Favorini, S, Dal Col, A, Minisola, S, Colangelo, L, Afeltra, A, Alemanno, P, Marigliano, B, Castellino, P, Blanco, J, Zanoli, L, Cattaneo, M, Fracasso, P, Amoruso, Mv, Saracco, V, Fogliati, M, Bussolino, C, Durante, V, Eusebi, G, Tirotta, D, Mete, F, Gino, M, Cittadini, A, Arcopinto, M, Salzano, A, Bobbio, E, Marra, Am, Sirico, D, Moreo, M, Scopelliti, F, Gasparini, F, Cocca, M, Ramirez Duque, N, Muela Molinero, A, Abad Requejo, P, Lopez Pelaez, V, Tamargo, L, Corbella Viros, X, Formiga, F, Diez Manglano, J, Bejarano Tello, E, Del Corral Behamonte, E, Sevil Puras, M, Manuel, R, Pinilla Llorente, B, Lopez Gonzalez Cobos, C, Villalba Garcia, Mv, Sanz Baena, S, Arroyo Gallego, M, Gonzalez Becerra, C, Fernandez Moyano, A, Mercedes Gomez, H, Poyato Borrego, M, Pacheco Cuadros, R, Perez Rojas, F, Garcia Olid, B, Carrascosa Garcia, S, Gonzalez Cruz, C, Peinado Martinez, M, Ruiz Cantero, A, Albarracín Arraigosa, A, Godoy Guerrero, M, Barón Ramos, Ma, Machin, Jm, Novo Veleiro, I, Alvela Suarez, L, Lopez, A, Rubal Bran, D, Iñiguez Vazquez, I, and Rios Prego, M.

Subjects
Male, medicine.medical_specialty, Phamacoepidemiology, Socio-culturale, Pain, Comorbidity, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Elderly, Internal medicine, Internal Medicine, medicine, Humans, Pain Management, 030212 general & internal medicine, Aged, Aged, 80 and over, Analgesics, business.industry, Anti-Inflammatory Agents, Non-Steroidal, Drug Utilization, Hospitalization, Non steroidal anti inflammatory, Italy, Cohort, Polypharmacy, Female, business, Elderly, Non-steroidal anti-inflammatory drugs, Phamacoepidemiology, Non-steroidal anti-inflammatory drugs
Published
2016

23. Le tignole della vite

Author

Anfora, G., Angeli, G., Baldessari, M., Ioriatti, C., Marchesini, E., Mattedi, L., Menke, F., Mescalchin, E., Schmidt, S., Tasin, M., and Varner, M.

Published
2007

30. Optical spectroscopic observations of gamma-ray blazar candidates. IX. Optical archival spectra and further observations from SOAR and OAGH

Author

Marco Landoni, Dan Milisavljevic, Alessandro Paggi, H. A. Peña-Herazo, Raffaele D'Abrusco, V. H. Chavushyan, F. La Franca, Federica Ricci, Gino Tosti, Francesco Massaro, Elena Jiménez-Bailón, E. J. Marchesini, N. Masetti, Howard A. Smith, Peña-Herazo, H. A., Massaro, F., Chavushyan, V., Marchesini, E. J., Paggi, A., Landoni, M., Masetti, N., Ricci, F., D’Abrusco, R., Milisavljevic, D., Jiménez-Bailón, E., La Franca, F., Smith, Howard A., and Tosti, G.

Subjects
Active galactic nucleus, active [Galaxies], Radiation mechanisms: non-thermal, media_common.quotation_subject, Population, FOS: Physical sciences, Galaxies: BL Lacertae objects, Astrophysics, Surveys, Galaxies: active, Quasars: general, 01 natural sciences, Cosmology, Observatory, 0103 physical sciences, Survey, Blazar, education, 010303 astronomy & astrophysics, media_common, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, education.field_of_study, non-thermal [Radiation mechanisms], Gamma ray, general [Quasars], Astronomy and Astrophysics, Quasar, Astrophysics - Astrophysics of Galaxies, Space and Planetary Science, Sky, Astrophysics of Galaxies (astro-ph.GA), Galaxies: BL Lacertae object, Astrophysics - High Energy Astrophysical Phenomena, BL Lacertae object [Galaxies]
Abstract

Nearly one-third of the sources in the $Fermi$-LAT catalogs lack a lower energy counterpart, hence being referred as unidentified/unassociated gamma-ray sources (UGSs). In order to firmly classify them, dedicated multifrequency follow-up campaigns are necessary. These will permit to unveil their nature and identify the fraction that could belong to the class of active galaxies known as blazars that is the largest population of extragalactic $\gamma$-ray sources. In $Fermi$-LAT catalogs there are also gamma-ray sources associated with multifrequency blazar-like objects known as Blazars Candidates of Uncertain type (i.e., BCUs) for which follow up spectroscopic campaigns are mandatory to confirm their blazar nature. Thus, in 2013 we started an optical spectroscopic campaign to identify blazar-like objects potential counterparts of UGSs and BCUs. Here we report the spectra of 31 additional targets observed as part of our follow up campaign. Thirteen of them are BCUs for which we acquired spectroscopic observations at Observatorio Astrof\'isico Guillermo Haro (OAGH) and at Southern Astrophysical Research Observatory (SOAR) telescopes, while the rest has been identified thanks to the archival observations available from the Sloan Digital Sky Survey (SDSS). We confirm the blazar nature of all BCUs: three of them are in blazar of quasar type (BZQs) while the remaining ones can be spectroscopically classified as BL Lac objects (BZBs). Then we also discovered 18 BL Lac objects lying within the positional uncertainty regions of UGSs that could be their potential counterparts., Comment: 30 pages and 65 figures

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results