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Introduction: The recent development of robust indices to quantify biological aging, along with the dynamic epidemiological transitions of population aging generate the unmet need to examine the extent up to which potential interventions can delay, halt or temporarily modulate aging trajectories. Methods and analysis: The study is a two-armed, open label randomised controlled trial. We aim to recruit 166 subjects, aged 60–75 years from the residential communities and old age clubs in Bangalore city, India, who will undergo randomisation into intervention or control arms (1:1). Intervention will include yoga sessions tailored for the older adults, 1 hour per day for 5 days a week, spread for 12 months. Data would be collected at the baseline, 26th week and 52nd week. The primary outcome of the study is estimation in biological age with yoga practice. The secondary outcomes will include cardinal mechanistic indicators of aging- telomere length, interleukin-6 (IL-6), tumor necrosis factor receptor II (TNF-RII), high sensitivity c-reactive protein (hsCRP)], insulin signaling [insulin and IGF1], renal function [cystatin], senescence [growth differentiating factor 15 (GDF-15)] and cardiovascular function [N-terminal B-type natriuretic peptides (NT-proBNP)]. Analyses will be by intention-to-treat model. Ethics & Dissemination: The study is approved by the Institutional Ethics Committee of Swami Vivekananda Yoga Anusandhana Samsthana University, Bangalore (ID:RES/IEC-SVYASA/242/2022). Written informed consent will be obtained from each participant prior to inclusion. Trial registration number: CTRI/2022/07/044442

1.1.Background:Learning difficulties, Stress and behavioural problems are widely prevalent in high school children that contribute to dropouts and poor performance. Yoga as a mind body intervention has been shown to improve performance in pilot studies. In this large observational study we assess the impact of yoga intervention on learning, cognitive abilities, behaviour and health in high school children. 1.2.Methods:Seven hundred and sixty eight schools across fifty talukas in Karnataka with around seven thousand six hundred and one children were assessed on improvements in learning, cognition, behaviour and health following two months of yoga intervention. Physical education teachers from these schools were trained to impart yoga intervention over two months to students of both higher primary and high school. Assessments were done by class teachers and parents of students who were not involved in imparting intervention. 1.3.Results:There was a significant improvement in health, learning ability, cognitive ability, behaviour, and positive emotions and decrease in negative emotions (all p’s