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Your search keyword '"Makowski K"' showing total 13 results
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13 results on '"Makowski K"'

1. Inhibitors of lipogenic enzymes as a potential therapy against cancer

Author

Montesdeoca N, López M, Ariza X, LAURA HERRERO RODRÍGUEZ, and Makowski K

Subjects
lipogenic enzyme inhibitors, lipid metabolism, cancer drugs
Abstract

Cancer cells rely on several metabolic pathways such as lipid metabolism to meet the increase in energy demand, cell division, and growth and successfully adapt to challenging environments. Fatty acid synthesis is therefore commonly enhanced in many cancer cell lines. Thus, relevant efforts are being made by the scientific community to inhibit the enzymes involved in lipid metabolism to disrupt cancer cell proliferation. We review the rapidly expanding body of inhibitors that target lipid metabolism, their side effects, and current status in clinical trials as potential therapeutic approaches against cancer. We focus on their molecular, biochemical and structural properties, selectivity and effectiveness and discuss their potential role as antitumor drugs.

Published
2020

4. The status, quality, and expansion of the NIH full-length cDNA project: The Mammalian Gene Collection (MGC)

Author

Gerhard, D. S., Wagner, L., Feingold, E. A., Shenmen, C. M., Grouse, L. H., Schuler, G., Klein, S. L., Old, S., Rasooly, R., Good, P., Guyer, M., Peck, A. M., Derge, J. G., Lipman, D., Collins, F. S., Jang, W., Sherry, S., Feolo, M., Misquitta, L., Lee, E., Rotmistrovsky, K., Greenhut, S. F., Schaefer, C. F., Buetow, K. H., Bonner, T. I., Haussler, D., Kent, J., Diekhans, M., Furey, T., Brent, M., Prange, C., Schreiber, K., Shapiro, N., Bhat, N. K., Hopkins, R. F., Hsie, F., Driscoll, T., Soares, M. B., Bonaldo, M. F., Casavant, T. L., Scheetz, T. E., Brownstein, M. J., Usdin, T. B., Toshiyuki, S., Carninci, P., Piao, Y., Dudekula, D. B., Ko, M. S. H., Kawakami, K., Suzuki, Y., Sugano, S., Gruber, C. E., Smith, M. R., Simmons, B., Moore, T., Waterman, R., Johnson, S. L., Ruan, Y., Lin Wei, C., Mathavan, S., Gunaratne, P. H., Wu, J., Garcia, A. M., Hulyk, S. W., Fuh, E., Yuan, Y., Sneed, A., Kowis, C., Hodgson, A., Muzny, D. M., John McPherson, Gibbs, R. A., Fahey, J., Helton, E., Ketteman, M., Madan, A., Rodrigues, S., Sanchez, A., Whiting, M., Young, A. C., Wetherby, K. D., Granite, S. J., Kwong, P. N., Brinkley, C. P., Pearson, R. L., Bouffard, G. G., Blakesly, R. W., Green, E. D., Dickson, M. C., Rodriguez, A. C., Grimwood, J., Schmutz, J., Myers, R. M., Butterfield, Y. S. N., Griffith, M., Griffith, O. L., Krzywinski, M. I., Liao, N., Morrin, R., Palmquist, D., Petrescu, A. S., Skalska, U., Smailus, D. E., Stott, J. M., Schnerch, A., Schein, J. E., Jones, S. J. M., Holt, R. A., Baross, A., Marra, M. A., Clifton, S., Makowski, K. A., Bosak, S., and Malek, J.

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