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7. Alveolar macrophages from AIDS patients spontaneously produce elevated levels of TNF-alpha in vitro

Author

Antinori, A., Enrica TAMBURRINI, Pagliari, G., Maiuro, G., Pallavicini, F., Luca, A., and Ortona, L.

Subjects
Adult, Male, Acquired Immunodeficiency Syndrome, Tumor Necrosis Factor-alpha, Pulmonary Fibrosis, Macrophage Activation, Middle Aged, Acute Disease, HIV Seropositivity, Macrophages, Alveolar, Humans, Female, Lung Diseases, Obstructive, Cells, Cultured
Abstract

In vitro production of TNF-alpha by alveolar macrophages was investigated in 15 AIDS patients with acute interstitial pneumonia and in 4 patients with asymptomatic HIV infection (anti-HIV+) and was compared to that observed in 6 patients with chronic pulmonary disease and in 5 normal controls (undergoing a fiberoptic bronchoscopy for suspected lung malignancy), all 11 HIV negative. Our results show that unstimulated alveolar macrophages of AIDS and anti-HIV+ patients released much more TNF-alpha than subjects with chronic obstructive pulmonary disease or healthy controls did: this overproduction may play a role in the pathogenesis of lung damage infection and particularly in AIDS patients.

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