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An unprecedented eco-friendly multi-component domino approach for the synthesis of novel spiroquinazolin-2-(thi)ones and quinolin-(thio)ureas is described. The protocol proceeds via domino double [4 + 2] annulations and features an eco-benign catalyst and solvent, simple starting materials, high atom-economy, H2O as the sole by-product and a simple work-up procedure.

The construction of online open course integrates modem information technology with education and teaching in depth. According to the needs of school students or social learners, relevant specialized courses are set up to promote teaching fairness, advantageous resource sharing and cultural protection. The construction of online open curriculum is a systematic project, which needs to consider the coordination of all levels from teachers to students. The construction of online open course solves the problem that learners are restricted by learning time, space and learning threshold. In a word, online open course is formed on the basis of criticizing the traditional teaching mode of university, and it is the supplement and perfection of the traditional teaching mode. This paper uses Excel to make tables to make data analysis results more clear and intuitive. In addition, the data is processed and analyzed in depth through pivottables.

Nontransferrin-bound iron (NTBI) is a heterogeneously speciated plasma iron, typically detectable when transferrin saturation (TfSat) exceeds 75%. Here, we examine factors affecting NTBI levels by a recently discovered direct chelator-based (CP851) fluorescent bead-linked flow-cytometric assay (bead-NTBI), compared with the established indirect nitrilotriacetate (NTA) assay in 122 iron-overloaded patients, including 64 on recent iron chelation therapy and 13 healthy volunteers. Both methods correlated (r = 0.57, P