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Your search keyword '"MESH: Mouth"' showing total 2 results
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2 results on '"MESH: Mouth"'

1. Bulk-solvent correction in large macromolecular structures

Author

B. Rees, Marat Yusupov, Lasse Jenner, Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Louis Pasteur - Strasbourg I, and Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Diffraction, Macromolecular Substances, MESH: Drug Interactions, MESH: Solvents, MESH: Thermus thermophilus, 010402 general chemistry, MESH: Amlodipine, 01 natural sciences, MESH: Mouth, Crystal, X-Ray Diffraction, Structural Biology, MESH: Tissue Plasminogen Activator, MESH: Cerebrovascular Accident, MESH: Treatment Outcome, Variable (mathematics), MESH: Middle Aged, MESH: Humans, 010405 organic chemistry, Chemistry, Thermus thermophilus, MESH: Tongue, Resolution (electron density), Isotropy, MESH: X-Ray Diffraction, MESH: Angiotensin-Converting Enzyme Inhibitors, MESH: Infarction, Middle Cerebral Artery, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, MESH: Macromolecular Substances, General Medicine, MESH: Male, 0104 chemical sciences, Solvent, Crystallography, MESH: Angioneurotic Edema, Chemical physics, MESH: Dexamethasone, Solvents, MESH: Acute Disease, MESH: Benzazepines, MESH: Histamine Antagonists, Constant (mathematics), Ribosomes, MESH: Ribosomes, Macromolecule
Abstract

International audience; The estimation of the bulk-solvent contribution to the diffraction of a macromolecular crystal makes use of a solvent mask which delimits the bulk-solvent regions in the crystal. It is shown that the way this mask is usually defined in CNS contains a bias which can lead to absurd results in the case of very large structures, where the calculations can only be made on relatively coarse grids. A modified procedure is described and applied to 70S ribosome data at 5.5 A resolution. The B factor affecting the bulk solvent is also discussed. Even in this case of very high and widely variable atomic B factors, it seems sufficient to consider a constant and isotropic B factor for the bulk solvent. This is initially set to the average value of the atomic B factor, but can be refined.

Published
2005
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2. How minute sooglossid frogs hear without a middle ear

Author

Thierry Aubin, Peter Cloetens, Philippe Herzog, Renaud Boistel, Nicolas Pollet, Thierry Scotti, Justin Gerlach, Françoise Peyrin, Jean-François Aubry, Centre de Neurosciences Paris-Sud (CNPS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Institut International de Paléoprimatologie, Paléontologie Humaine : Evolution et Paléoenvironnement (IPHEP), Centre National de la Recherche Scientifique (CNRS)-Université de Poitiers, European Synchrotron Radiation Facility (ESRF), Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Sons, Laboratoire de Mécanique et d'Acoustique [Marseille] (LMA ), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Institut de biologie systémique et synthétique (ISSB), Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), Physique des ondes pour la médecine, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0106 biological sciences, medicine.medical_specialty, MESH: Biomechanical Phenomena, MESH: Anura, MESH: Vocalization, Animal, Sensory system, [SDV.BID]Life Sciences [q-bio]/Biodiversity, Biology, Audiology, 010603 evolutionary biology, 01 natural sciences, Models, Biological, MESH: Mouth, 03 medical and health sciences, Bone conduction, Hearing, medicine, otorhinolaryngologic diseases, Animals, MESH: Animals, MESH: Bone Conduction, MESH: Hearing, 030304 developmental biology, Sechellophryne gardineri, 0303 health sciences, Mouth, Multidisciplinary, MESH: Models, Biological, Anatomy, Biological Sciences, Biomechanical Phenomena, medicine.anatomical_structure, Ear, Inner, Acoustic propagation, Middle ear, MESH: Synchrotrons, sense organs, Anura, Vocalization, Animal, [SDU.STU.PG]Sciences of the Universe [physics]/Earth Sciences/Paleontology, Bone Conduction, MESH: Ear, Inner, Synchrotrons
Abstract

International audience; Acoustic communication is widespread in animals. According to the sensory drive hypothesis [Endler JA (1993) Philos Trans R Soc Lond B Biol Sci 340(1292):215-225], communication signals and perceptual systems have coevolved. A clear illustration of this is the evolution of the tetrapod middle ear, adapted to life on land. Here we report the discovery of a bone conduction-mediated stimulation of the ear by wave propagation in Sechellophryne gardineri, one of the world's smallest terrestrial tetrapods, which lacks a middle ear yet produces acoustic signals. Based on X-ray synchrotron holotomography, we measured the biomechanical properties of the otic tissues and modeled the acoustic propagation. Our models show how bone conduction enhanced by the resonating role of the mouth allows these seemingly deaf frogs to communicate effectively without a middle ear.

Published
2013
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