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1. Association of high-risk coronary atherosclerosis at CCTA with clinical and circulating biomarkers: Insight from CAPIRE study

Author

Edoardo Conte, Daniele Andreini, Marco Magnoni, Serge Masson, Saima Mushtaq, Sergio Berti, Mauro Canestrari, Giancarlo Casolo, Domenico Gabrielli, Roberto Latini, Paolo Marraccini, Tiziano Moccetti, Maria Grazia Modena, Gianluca Pontone, Marco Gorini, Aldo P. Maggioni, Attilio Maseri, A. Maseri, D. Andreini, S. Berti, M. Canestrari, G. Casolo, D. Gabrielli, R. Latini, M. Magnoni, P. Marraccini, S. Masson, T. Moccetti, M.G. Modena, G. Pontone, F. Gaspari, S. Ferrari, A. Cannata, N. Stucchi, M. Fois, R. Bernasconi, G. Balconi, T. Vago, T. Letizia, B. Bottazzi, R. Leone, I. Suliman, M. Sommaruga, P. Gremigni, R. Olivieri, L. Pennacchietti, M. Magnacca, M.G. Rossi, E. Pasotti, A. Clemente, S. Mushtaq, E. Mauro, R. Rossi, F. Pigazzani, L. Faggioni, M. Ciardetti, and M. Puppato

Subjects
Male, Computed Tomography Angiography, Coronary Artery Disease, 030204 cardiovascular system & hematology, Coronary Angiography, Logistic regression, 030218 nuclear medicine & medical imaging, 0302 clinical medicine, Risk Factors, Prevalence, Medicine, Prospective Studies, Age Factors, Coronary ct angiography, Middle Aged, Prognosis, Inflammatory biomarkers, Plaque, Atherosclerotic, Serum Amyloid P-Component, C-Reactive Protein, Italy, Cohort, Female, Cardiology and Cardiovascular Medicine, Coronary plaque, Clinical risk factor, medicine.medical_specialty, Cardiac computed tomography, Risk Assessment, 03 medical and health sciences, Sex Factors, Predictive Value of Tests, Diabetes mellitus, Internal medicine, Multidetector Computed Tomography, Humans, Radiology, Nuclear Medicine and imaging, Coronary atherosclerosis, Aged, Glycated Hemoglobin, Inflammation, business.industry, High-risk plaque features, medicine.disease, Cardiovascular prevention, Circulating biomarkers, Cross-Sectional Studies, business, Biomarkers
Abstract

Background High-risk coronary atherosclerosis features evaluated coronary CT angiography (CCTA) were suggested to have a prognostic role. The present study aimed to evaluate the association of circulating biomarkers with high-risk plaque features assessed by CCTA. Methods A consecutive cohort of subjects who underwent CCTA because of suspected CAD was screened for inclusion in the CAPIRE study. Based on risk factors (RF) burden patients were defined as having a low clinical risk (0–1 RF with the exclusion of patients with diabetes mellitus as single RF) or an high clinical risk (≥3 RFs). In all patients, measurement of inflammatory biomarkers and CCTA analysis focused on high-risk plaque features were performed. Univariate and multivariate logistic regression analysis were used to evaluate the relationship between clinical and biological variables with CCTA advanced plaque features. Results 528 patients were enrolled in CAPIRE study. Older age and male sex appeared to be predictors of qualitative high-risk plaque features and associated with the presence of elevated total, non-calcified and low-attenuation plaque volume. Among circulating biomarkers only hs-CRP was found to be associated with qualitative high-risk plaque features (OR 2.02, p = 0.004 and 2.02, p = 0.012 for LAP and RI > 1.1, respectively) with borderline association with LAP-Vol (OR 1.52, p = 0.076); HbA1c and PTX-3 resulted to be significantly associated with quantitative high-risk plaque features (OR 1.71, p = 0.003 and 1.04, p = 0.002 for LAP-Vol, respectively). Conclusions Our results support the association between inflammatory biomarkers (hs-CRP, PTX- 3), HbA1c and high-risk atherosclerotic features detected by CCTA. Male sex and older age are significant predictors of high-risk atherosclerosis.

Published
2021
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2. Title Page / Table of Contents / Preface

Author

Benvindo Justiça, E. Segalés, Gloria Saccani, Evy Bashardi, Andrew N. Nicolaides, Armando Tripodi, T. Fenyvesi, G. Origliani, J. Vermylen, R. Rossi, A. Nemmar, Alexander Koshkaryev, Silvia Navarro, S. Béguin, Francesco Violi, Tiziana Garofano, Antonella Tufano, Uri Seligsohn, Fabrizio Fabris, H.C. Hemker, G. Vilahur, Franco Semprini, R. Abbate, S. Fedi, Saul Yedgar, Sara Morais, C. Fatini, Licia Iacoviello, Irène Juhan-Vague, F. Gensini, Helga Grafenhofer, P. Giesen, S. Coccheri, B. Nemery, P. Carrasco, T. Grimaldi, Jacqueline Conard, G. Fantini, Ida Martinelli, Chiara Melloni, F.R. Rosendaal, Francesco Fallani, Gordon D.O. Lowe, E. Sticchi, Mónica Pereira, Joseph Loscalzo, J.I. Abad, V. Regnault, Juan Carlos Souto, T. Lecompte, Gregory Barshtein, Giovanni Romeo, V.V. Kakkar, Ingrid Pabinger, Ebrahim Shah, Giovanni Di Minno, A. De Fabritiis, F. Sofi, Pilar Medina, Alexandra Estevinho, Matteo Nicola Dario Di Minno, Justo Aznar, E. Conti, Grigoris T. Gerotziafas, George Geroulakos, E. de Smed, Maria Assunta Silvestri, Giuseppe G. Nenci, Fabio M. Pulcinelli, Luisa Lenti, Ismail Elalamy, B. Cosmi, Pierre Morange, Amparo Estellés, Angelo Branzi, Marie-Christine Alessi, Andrew H. Baker, Roberto Catasca, Raymond Verhaeghe, Samuele Nanni, V. Llorente, Francisco España, Andrea Ghiselli, F. Coppi, Domenico Prisco, Manuel Campos, M.F. Hoylaerts, P. Poredoš, Meyer Michel Samama, Stavros K. Kakkos, Giovanni Melandri, José Miguel P. Ferreira de Oliveira, Maura Griffin, David A. Lane, R. AlDieri, Augusto Di Castelnuovo, Serenella Rotondo, L. Badimon, J.J. Badimon, Giovanna Marchetti, Antonella Marcoccia, M.G. Modena, Henrik Sillesen, Joseph Emmerich, Daniela Turchetti, Luigina R. Mollica, Giovanni de Gaetano, Rossella Marcucci, Maria Benedetta Donati, José Manuel Cabeda, Pasquale Pignatelli, Giuseppe Germanò, Pierluigi Tricoci, J. Harenberg, Marie Hélène Horellou, Gianni Belcaro, Antonio Girolami, Bruno Girolami, R. Wagenvoord, Francesco Bernardi, M. Verstraete, P.M. Mannucci, Jean-Noël Fiessinger, I. Jörg, and Irene Pereira

Subjects
medicine.medical_specialty, business.industry, Physiology (medical), medicine, Table of contents, Hematology, Title page, business, Classics, Surgery
Published
2003
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3. Contents Vol. 32, 2002

Author

Giovanna Marchetti, Antonella Marcoccia, Domenico Prisco, Giovanni Melandri, J.J. Badimon, Mónica Pereira, Justo Aznar, Angelo Branzi, Roberto Catasca, Francesco Violi, Licia Iacoviello, P.M. Mannucci, Andrew N. Nicolaides, Jean-Noël Fiessinger, Francisco España, Gregory Barshtein, Fabrizio Fabris, Luisa Lenti, Maria Assunta Silvestri, Matteo Nicola Dario Di Minno, S. Coccheri, Samuele Nanni, F. Coppi, F.R. Rosendaal, T. Fenyvesi, Alexander Koshkaryev, M.F. Hoylaerts, Luigina R. Mollica, Andrea Ghiselli, Alexandra Estevinho, A. De Fabritiis, Silvia Navarro, P. Poredoš, Irène Juhan-Vague, H.C. Hemker, Pierluigi Tricoci, José Manuel Cabeda, R. Abbate, G. Vilahur, Antonella Tufano, P. Carrasco, S. Fedi, J. Harenberg, Tiziana Garofano, Fabio M. Pulcinelli, M.G. Modena, Saul Yedgar, Juan Carlos Souto, Henrik Sillesen, B. Cosmi, Meyer Michel Samama, Raymond Verhaeghe, Ingrid Pabinger, P. Giesen, Ebrahim Shah, Pasquale Pignatelli, Giuseppe Germanò, David A. Lane, Jacqueline Conard, Augusto Di Castelnuovo, T. Grimaldi, Pierre Morange, Marie-Christine Alessi, José Miguel P. Ferreira de Oliveira, Daniela Turchetti, Gloria Saccani, V. Regnault, Joseph Emmerich, Giovanni de Gaetano, Rossella Marcucci, Maria Benedetta Donati, Manuel Campos, J. Vermylen, Marie Hélène Horellou, Ida Martinelli, Serenella Rotondo, R. AlDieri, E. Sticchi, Giuseppe G. Nenci, F. Sofi, Sara Morais, Helga Grafenhofer, F. Gensini, C. Fatini, Chiara Melloni, Franco Semprini, R. Wagenvoord, Francesco Bernardi, M. Verstraete, I. Jörg, Grigoris T. Gerotziafas, Gianni Belcaro, Antonio Girolami, Bruno Girolami, Gordon D.O. Lowe, Joseph Loscalzo, Giovanni Romeo, V.V. Kakkar, Giovanni Di Minno, Irene Pereira, Benvindo Justiça, Ismail Elalamy, T. Lecompte, G. Fantini, Francesco Fallani, Pilar Medina, V. Llorente, L. Badimon, E. Conti, Armando Tripodi, G. Origliani, R. Rossi, Stavros K. Kakkos, Maura Griffin, George Geroulakos, E. de Smed, A. Nemmar, Amparo Estellés, Andrew H. Baker, Uri Seligsohn, B. Nemery, S. Béguin, J.I. Abad, E. Segalés, and Evy Bashardi

Subjects
medicine.medical_specialty, business.industry, Physiology (medical), General surgery, medicine, Hematology, business, Surgery
Published
2002
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4. Differential effects of β-blockers in patients with heart failure: a prospective, randomized, double-blind comparison of the long-term effects of metoprolol vs. carvedilol

Author

M. Metra, M.G. Modena, S. Nodari, E Boldi, R. Giubbini, and L. DelCas

Subjects
medicine.medical_specialty, business.industry, medicine.disease, Term (time), Double blind, Heart failure, Internal medicine, medicine, Cardiology, In patient, Cardiology and Cardiovascular Medicine, business, Carvedilol, General Nursing, Metoprolol, medicine.drug
Published
2001
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5. Vascular surgery patients: perioperative and long-term risk according to the ACC/AHA guidelines, the additive role of post-operative troponin elevation

Author

Luciano Babuin, Maria Grazia Modena, Andrea Barbieri, Luigi Politi, A Rumolo, Allan S. Jaffe, Mauro Zennaro, Francesca Bursi, Andrea Stella, Mauro Gargiulo, Teresa Grimaldi, F. Bursi, L. Babuin, A. Barbieri, L. Politi, M. Zennaro, T. Grimaldi, A. Rumolo, M. Gargiulo, A. Stella, M.G. Modena, and A.S. Jaffe

Subjects
Adult, Male, medicine.medical_specialty, Adrenergic beta-Antagonists, Cardiology, Myocardial Infarction, Disease-Free Survival, Postoperative Complications, Risk Factors, Internal medicine, Troponin I, medicine, Humans, Myocardial infarction, Prospective Studies, Risk factor, Societies, Medical, Postoperative Care, biology, business.industry, Hazard ratio, Vascular surgery, post-operative troponin elevation, Perioperative, medicine.disease, Prognosis, Troponin, Surgery, Circulatory system, Multivariate Analysis, Practice Guidelines as Topic, biology.protein, Female, Cardiology and Cardiovascular Medicine, business, Vascular Surgical Procedures
Abstract

Aims The objectives of this study are to evaluate the prognostic role of pre-operative stratification in patients undergoing elective major vascular surgery, the timing of adverse outcomes, and the predictive role of troponin (cTn). Methods and results Consecutive vascular surgery candidates (n ¼ 391) were prospectively stratified and treated according to the ACC/AHA guidelines. The patients were categorized into three groups: (1) with coronary revascularization in the past 5 years, (2) with intermediate clinical risk predictors, and (3) with minor or no clinical risk predictors. cTnI was measured post-operatively. By 18 months, 18.7% of subjects had experienced death or acute myocardial infarction (MI) (by the ACC/ESC criteria). The hazard ratio (HR) was 5.21 (95% CI ¼ 2.60–10.43; P , 0.0001) in group 1 and 2.58 (95% CI ¼ 1.27–4.38; P ¼ 0.004) in group 2 when compared with group 3. Most events occurred within 30 days. Elevations of cTnI were associated with adverse outcomes even after multivariable adjustment at long-term (adjusted overall HR ¼ 4.73, 95% CI ¼ 2.92–7.65; P , 0.0001) and at 30 days (adjusted HR ¼ 5.52, 95%CI ¼ 3.23–9.42; P , 0.0001). Conclusion After pre-operative stratification, patients undergoing elective major vascular surgery remain at high risk of MI and death. Events occur mainly early after surgery. cTnI elevations are frequent and independently associated with increased risk. These findings suggest the need for a major re-evaluation of our approach to these patients.

Published
2005

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