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A new depsidone derivative botryorhodine I (1), along with eight known compounds (2-9) were obtained from solid rice cultures of the fungal strain, Lasiodiplodia theobromae M4.2-2 isolated from a mangrove sediment sample. The structures of the isolated compounds were elucidated on the basis of 1 D and 2 D NMR analysis as well as by HRESIMS. All compounds were evaluated for their cytotoxic potential against the mouse lymphoma cell line L5178Y as well as for their antibacterial activities against a panel of Gram-positive and Gram-negative bacterial strains. Compound 3 revealed potent cytotoxic activity with an IC50 of 7.3 µM whereas compound 7 showed selective anti-bacterial activity against different S. aureus and E. faecium bacterial strains with MIC value of 25 µg/ml.

Anti-infective and biofilm-inhibiting activities of aryl isoquinoline-derivatives of the general formulae 1 to 3 Figure US08173673-20120508-C00001 are described.

Es werden das verbrückte Angucyclinon Gephyromycin (1a) und Derivate dieser Verbindung nach der allgemeinen Formel 1 beschrieben sowie ein Verfahren zu ihrer Herstellung. Diese Substanzen erhöhen die intrazelluläre Calciumkonzentration in Neuronen. Weiterhin besitzen sie eine antibiotische Wirkung gegenüber Gram-positiven Bakterien.

Es werden Tajixanthonhydrat sowie Tajixanthonhydrat-Derivate der allgemeinen Formel I $F1 beschrieben sowie ein Verfahren zu ihrer Herstellung. Tajixanthonhydrat besitzt u. a. eine ausgeprägte Biofilm-inhibierende Wirkung gegen Staphylococcus epidermidis.