252 results on '"Luigi Palmieri"'
Search Results
2. Health literacy related to health care, disease prevention, and health promotion in the Italian adult population
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Luigi Palmieri, Chiara Lorini, Chiara Cadeddu, Aldo Rosano, Chiara Donfrancesco, Guglielmo Bonaccorsi, Paola Castro, Cinzia Noce, Claudia Meduri, Matilde Bocci, Daniela Galeone, Graziano Onder, and Brigid Unim
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Health (social science) ,Epidemiology ,Health Policy ,Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) ,Health Informatics - Published
- 2023
3. The PHIRI project for measuring the impact of health crises on the European Healthcare System: the Italian case in COVID-19 pandemic
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Andrea Faragalli, Eugenio Mattei, Martin Thissen, Flavia Carle, Brigid Unim, Rosaria Gesuita, Ronan Lyons, Sarah Aldridge, Francisco Estupiñán-Romero, Andrea Shmidt, Enrique Bernal-Delgado, and Luigi Palmieri
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Health (social science) ,Epidemiology ,Health Policy ,Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) ,Health Informatics - Published
- 2023
4. Self-reported vs measured body mass index in the italian adults within cuore project 2018-19
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Chiara Donfrancesco, Laura Iannucci, Emanuela Bologna, Elisabetta Profumo, Cinzia Lonoce, Brigitta Buttari, Anna Lonardo, Serena Vannucchi, and Luigi Palmieri
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Health (social science) ,Epidemiology ,Health Policy ,Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) ,Health Informatics - Published
- 2023
5. Supplementary Figure S3 from Statins Reduce Intratumor Cholesterol Affecting Adrenocortical Cancer Growth
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Rosa Sirianni, Ivan Casaburi, Vincenzo Pezzi, Antonio M. Lerario, Luigi Palmieri, Simona N. Barile, Francesco M. Lasorsa, Catia Pilon, Raffaele Pezzani, Francesco Fallo, Rocco Malivindi, Marta C. Nocito, Sara Sculco, Arianna De Luca, Vittoria Rago, Adele Chimento, Paola Avena, and Francesca Trotta
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Supplementary Fig. S3 shows that mevalonate and estradiol prevent simvastatin inhibitory effects.
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- 2023
6. Supplementary Figure S4 from Statins Reduce Intratumor Cholesterol Affecting Adrenocortical Cancer Growth
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Rosa Sirianni, Ivan Casaburi, Vincenzo Pezzi, Antonio M. Lerario, Luigi Palmieri, Simona N. Barile, Francesco M. Lasorsa, Catia Pilon, Raffaele Pezzani, Francesco Fallo, Rocco Malivindi, Marta C. Nocito, Sara Sculco, Arianna De Luca, Vittoria Rago, Adele Chimento, Paola Avena, and Francesca Trotta
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Supplementary Fig. S4 shows the apoptotic mechanism activated by statins in ACC cells
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- 2023
7. Supplementary Figure S1 from Statins Reduce Intratumor Cholesterol Affecting Adrenocortical Cancer Growth
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Rosa Sirianni, Ivan Casaburi, Vincenzo Pezzi, Antonio M. Lerario, Luigi Palmieri, Simona N. Barile, Francesco M. Lasorsa, Catia Pilon, Raffaele Pezzani, Francesco Fallo, Rocco Malivindi, Marta C. Nocito, Sara Sculco, Arianna De Luca, Vittoria Rago, Adele Chimento, Paola Avena, and Francesca Trotta
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Supplementary Fig. S1 shows that statins affect ACC cell viability
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- 2023
8. Supplementary methods from Statins Reduce Intratumor Cholesterol Affecting Adrenocortical Cancer Growth
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Rosa Sirianni, Ivan Casaburi, Vincenzo Pezzi, Antonio M. Lerario, Luigi Palmieri, Simona N. Barile, Francesco M. Lasorsa, Catia Pilon, Raffaele Pezzani, Francesco Fallo, Rocco Malivindi, Marta C. Nocito, Sara Sculco, Arianna De Luca, Vittoria Rago, Adele Chimento, Paola Avena, and Francesca Trotta
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Supplementary methods
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- 2023
9. Supplementary Figure S2 from Statins Reduce Intratumor Cholesterol Affecting Adrenocortical Cancer Growth
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Rosa Sirianni, Ivan Casaburi, Vincenzo Pezzi, Antonio M. Lerario, Luigi Palmieri, Simona N. Barile, Francesco M. Lasorsa, Catia Pilon, Raffaele Pezzani, Francesco Fallo, Rocco Malivindi, Marta C. Nocito, Sara Sculco, Arianna De Luca, Vittoria Rago, Adele Chimento, Paola Avena, and Francesca Trotta
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Supplementary Fig. S2 shows Immunohistochemical staining of H295R xenograft samples.
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- 2023
10. Mitochondrial transport and metabolism of the major methyl donor and versatile cofactor S‐adenosylmethionine, and related diseases: A review †
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Magnus Monné, Carlo M. T. Marobbio, Gennaro Agrimi, Luigi Palmieri, and Ferdinando Palmieri
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S-Adenosylmethionine ,Amino Acid Transport Systems ,Calcium-Binding Proteins ,Clinical Biochemistry ,Genetics ,Humans ,Biological Transport ,Cell Biology ,Molecular Biology ,Biochemistry ,Mitochondria - Abstract
S-adenosyl-L-methionine (SAM) is a coenzyme and the most commonly used methyl-group donor for the modification of metabolites, DNA, RNA and proteins. SAM biosynthesis and SAM regeneration from the methylation reaction product S-adenosyl-L-homocysteine (SAH) take place in the cytoplasm. Therefore, the intramitochondrial SAM-dependent methyltransferases require the import of SAM and export of SAH for recycling. Orthologous mitochondrial transporters belonging to the mitochondrial carrier family have been identified to catalyze this antiport transport step: Sam5p in yeast, SLC25A26 (SAMC) in humans, and SAMC1-2 in plants. In mitochondria SAM is used by a vast number of enzymes implicated in the following processes: the regulation of replication, transcription, translation, and enzymatic activities; the maturation and assembly of mitochondrial tRNAs, ribosomes and protein complexes; and the biosynthesis of cofactors, such as ubiquinone, lipoate, and molybdopterin. Mutations in SLC25A26 and mitochondrial SAM-dependent enzymes have been found to cause human diseases, which emphasizes the physiological importance of these proteins.
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- 2022
11. New Insights into the Evolution and Gene Structure of the Mitochondrial Carrier Family Unveiled by Analyzing the Frequent and Conserved Intron Positions
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Magnus Monné, Antonia Cianciulli, Maria A Panaro, Rosa Calvello, Anna De Grassi, Luigi Palmieri, Vincenzo Mitolo, and Ferdinando Palmieri
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Genetics ,Molecular Biology ,Ecology, Evolution, Behavior and Systematics - Abstract
Mitochondrial carriers (MCs) belong to a eukaryotic protein family of transporters that in higher organisms is called the solute carrier family 25 (SLC25). All MCs have characteristic triplicated sequence repeats forming a 3-fold symmetrical structure of a six-transmembrane α-helix bundle with a centrally located substrate-binding site. Biochemical characterization has shown that MCs altogether transport a wide variety of substrates but can be divided into subfamilies, each transporting a few specific substrates. We have investigated the intron positions in the human MC genes and their orthologs of highly diversified organisms. The results demonstrate that several intron positions are present in numerous MC sequences at the same specific points, of which some are 3-fold symmetry related. Many of these frequent intron positions are also conserved in subfamilies or in groups of subfamilies transporting similar substrates. The analyses of the frequent and conserved intron positions in MCs suggest phylogenetic relationships not only between close but also distant homologs as well as a possible involvement of the intron positions in the evolution of the substrate specificity diversification of the MC family members.
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- 2023
12. Mitochondrial transport and metabolism of the vitamin B‐derived cofactors thiamine pyrophosphate, coenzyme A, <scp>FAD</scp> and <scp>NAD</scp> + , and related diseases: A review
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Ferdinando Palmieri, Magnus Monné, Giuseppe Fiermonte, and Luigi Palmieri
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Clinical Biochemistry ,Genetics ,Cell Biology ,Molecular Biology ,Biochemistry - Published
- 2022
13. Citrate Regulates the
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Roberta, Seccia, Silvia, De Santis, Maria A, Di Noia, Ferdinando, Palmieri, Daniela V, Miniero, Raffaele, Marmo, Eleonora, Paradies, Antonella, Santoro, Ciro L, Pierri, Luigi, Palmieri, Carlo M T, Marobbio, and Angelo, Vozza
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The yeast mitochondrial transport of GTP and GDP is mediated by Ggc1p, a member of the mitochondrial carrier family. The physiological role of Ggc1p in
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- 2022
14. Generation of a Yeast Cell Model Potentially Useful to Identify the Mammalian Mitochondrial N-Acetylglutamate Transporter
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Ruggiero Gorgoglione, Roberta Seccia, Amer Ahmed, Angelo Vozza, Loredana Capobianco, Alessia Lodi, Federica Marra, Eleonora Paradies, Luigi Palmieri, Vincenzo Coppola, Vincenza Dolce, and Giuseppe Fiermonte
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N-acetylglutamate ,urea cycle ,mitochondrial carriers ,yeast cell model ,Molecular Biology ,Biochemistry - Abstract
The human mitochondrial carrier family (MCF) consists of 53 members. Approximately one-fifth of them are still orphans of a function. Most mitochondrial transporters have been functionally characterized by reconstituting the bacterially expressed protein into liposomes and transport assays with radiolabeled compounds. The efficacy of this experimental approach is constrained to the commercial availability of the radiolabeled substrate to be used in the transport assays. A striking example is that of N-acetylglutamate (NAG), an essential regulator of the carbamoyl synthetase I activity and the entire urea cycle. Mammals cannot modulate mitochondrial NAG synthesis but can regulate the levels of NAG in the matrix by exporting it to the cytosol, where it is degraded. The mitochondrial NAG transporter is still unknown. Here, we report the generation of a yeast cell model suitable for identifying the putative mammalian mitochondrial NAG transporter. In yeast, the arginine biosynthesis starts in the mitochondria from NAG which is converted to ornithine that, once transported into cytosol, is metabolized to arginine. The deletion of ARG8 makes yeast cells unable to grow in the absence of arginine since they cannot synthetize ornithine but can still produce NAG. To make yeast cells dependent on a mitochondrial NAG exporter, we moved most of the yeast mitochondrial biosynthetic pathway to the cytosol by expressing four E. coli enzymes, argB-E, able to convert cytosolic NAG to ornithine. Although argB-E rescued the arginine auxotrophy of arg8∆ strain very poorly, the expression of the bacterial NAG synthase (argA), which would mimic the function of a putative NAG transporter increasing the cytosolic levels of NAG, fully rescued the growth defect of arg8∆ strain in the absence of arginine, demonstrating the potential suitability of the model generated.
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- 2023
15. Microbiologically confirmed infections and antibiotic-resistance in a national surveillance study of hospitalised patients who died with COVID-19, Italy 2020–2021
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Floridia, Marco, Giuliano, Marina, Monaco, Monica, Palmieri, Luigi, Lo Noce, Cinzia, Palamara, Anna Teresa, Pantosti, Annalisa, Brusaferro, Silvio, Onder, Graziano, The Italian National Institute of Health Covid-Mortality Group: Luigi Palmieri, Elvira, Agazio, Pierfrancesco, Barbariol, Antonino, Bella, Eva, Benelli, Luigi, Bertinato, Matilde, Bocci, Stefano, Boros, Marco, Bressi, Giovanni, Calcagnini, Marco, Canevelli, Federica, Censi, Alessandra, Ciervo, Elisa, Colaizzo, Roberto Da Cas, Martina Del Manso, Corrado Di Benedetto, Chiara, Donfrancesco, Massimo, Fabiani, Francesco, Facchiano, Marco, Floridia, Fabio, Galati, Marina, Giuliano, Tiziana, Grisetti, Cecilia, Guastadisegni, Ilaria, Lega, Cinzia Lo Noce, Pietro, Maiozzi, Valerio, Manno, Margherita, Martini, Marco, Massari, Alberto Mateo Urdiales, Eugenio, Mattei, Claudia, Meduri, Paola, Meli, Francesca Menniti Ippolito, Giada, Minelli, Graziano, Onder, Daniele, Petrone, Patrizio, Pezzotti, Flavia, Pricci, Ornella, Punzo, Federica, Quarata, Raparelli, Valeria, Flavia, Riccardo, Simone, Rocchetto, Chiara, Sacco, Paolo, Salerno, Giulia, Sarti, Debora, Serra, Stefania Spila Alegiani, Matteo, Spuri, Marco, Tallon, Manuela Tamburo De Bella, Dorina, Tiple, Marco Toccaceli Blasi, Federica, Trentin, Brigid, Unim, Luana, Vaianella, Nicola, Vanacore, Maria Fenicia Vescio, Emanuele Rocco Villani, Liliana Elena Weimer, and Silvio, Brusaferro
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Microbiology (medical) ,Co-infections ,Coinfection ,Public Health, Environmental and Occupational Health ,Ambientale ,COVID-19 ,Bacteremia ,Drug Resistance, Microbial ,Antimicrobial resistance ,Lower respiratory tract infections ,Anti-Bacterial Agents ,Hospitalization ,Fungal infections ,Infectious Diseases ,Italy ,Bacterial infections ,Population Surveillance ,Humans ,Pharmacology (medical) ,Bloodstream infections ,Secondary infections ,LS6_7 ,Fungemia ,Respiratory Tract Infections - Abstract
Background Patients hospitalised for COVID-19 may present with or acquire bacterial or fungal infections that can affect the course of the disease. The aim of this study was to describe the microbiological characteristics of laboratory-confirmed infections in hospitalised patients with severe COVID-19. Methods We reviewed the hospital charts of a sample of patients deceased with COVID-19 from the Italian National COVID-19 Surveillance, who had laboratory-confirmed bacterial or fungal bloodstream infections (BSI) or lower respiratory tract infections (LRTI), evaluating the pathogens responsible for the infections and their antimicrobial susceptibility. Results Among 157 patients with infections hospitalised from February 2020 to April 2021, 28 (17.8%) had co-infections (≤ 48 h from admission) and 138 (87.9%) had secondary infections (> 48 h). Most infections were bacterial; LRTI were more frequent than BSI. The most common co-infection was pneumococcal LRTI. In secondary infections, Enterococci were the most frequently recovered pathogens in BSI (21.7% of patients), followed by Enterobacterales, mainly K. pneumoniae, while LRTI were mostly associated with Gram-negative bacteria, firstly Enterobacterales (27.4% of patients, K. pneumoniae 15.3%), followed by A. baumannii (19.1%). Fungal infections, both BSI and LRTI, were mostly due to C. albicans. Antibiotic resistance rates were extremely high in Gram-negative bacteria, with almost all A. baumannii isolates resistant to carbapenems (95.5%), and K. pneumoniae and P. aeruginosa showing carbapenem resistance rates of 59.5% and 34.6%, respectively. Conclusions In hospitalised patients with severe COVID-19, secondary infections are considerably more common than co-infections, and are mostly due to Gram-negative bacterial pathogens showing a very high rate of antibiotic resistance.
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- 2022
16. Benchmarking the utility of maps of dynamics for human-aware motion planning
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Chittaranjan Srinivas, Swaminathan, Tomasz Piotr, Kucner, Martin, Magnusson, Luigi, Palmieri, Sergi, Molina, Anna, Mannucci, Federico, Pecora, and Achim J, Lilienthal
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Robots operating with humans in highly dynamic environments need not only
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- 2022
17. LIPIC: An Automated Workflow to Account for Isotopologue-Related Interferences in Electrospray Ionization High-Resolution Mass Spectra of Phospholipids
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Pietro Santamaria, Luigi Palmieri, Beniamino Leoni, Tommaso R. I. Cataldi, Maria Antonietta Di Noia, Ilario Losito, Andrea Castellaneta, Cosima Damiana Calvano, and Davide Coniglio
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Isotope ,Resolution (mass spectrometry) ,Chemistry ,Electrospray ionization ,Hydrophilic interaction chromatography ,Gaussian ,010401 analytical chemistry ,Analytical chemistry ,010402 general chemistry ,Interference (wave propagation) ,01 natural sciences ,0104 chemical sciences ,symbols.namesake ,Structural Biology ,Mass spectrum ,symbols ,Isotopologue ,Spectroscopy - Abstract
In the past decade, hydrophilic interaction liquid chromatography (HILIC) has emerged as an efficient alternative to reversed-phase chromatography (RPC) for the analysis of phospholipid (PL) mixtures based on mass spectrometric detection. Since the separation of PL by HILIC is chiefly based on their headgroup, the mass spectrum of each class can be obtained by spectral averaging under the corresponding HILIC band. Using experimental m/z values resulting from high mass resolution/accuracy instruments, the sum compositions of PL in a specific class can be thus inferred but partial overlapping may occur between signals related to the M + 0 isotopologue of one species and the M + 2/M + 4 isotopologues of species having one/two more C═C bonds in their chemical structures. Here, an automated workflow, named LIPIC (lipid isotopic pattern interference correction), is proposed to account for such interferences. Starting from the experimentally verified assumption that peaks in isotope patterns are Gaussian, LIPIC predicts, as a function of m/z ratio, signal intensities due to M + 2 and M + 4 isotopologues of species with one or two more C = C bonds than the target one and calculates the corrected intensity for the M + 0 isotopologue of the latter. Thanks to an iterative procedure, the suggested algorithm compensates also for slight shifts occurring between experimental and theoretical m/z ratios related to isotopologue peaks. Examples of applications to simulated and experimental mass spectra of two PL classes, i.e., phosphatidylcholines (PC) and cardiolipins (CL), emphasize the increased extent of correction at the increase of molecular masses of involved species.
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- 2021
18. Trend in potassium intake and Na/K ratio in the Italian adult population between the 2008 and 2018 CUORE project surveys
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Cinzia Lo Noce, Daniela Minutoli, Brigitta Buttari, Ornella Russo, Serena Vannucchi, Elisabetta Profumo, Simona Giampaoli, Paolo Bellisario, Pasquale Strazzullo, Daniela Galeone, Andrea Di Lenarda, Francesca Vespasiano, Roberto Iacone, Luigi Palmieri, Anna Di Lonardo, Graziano Onder, Ferruccio Galletti, Chiara Donfrancesco, Donfrancesco, C., Lo Noce, C., Russo, O., Buttari, B., Profumo, E., Minutoli, D., Di Lonardo, A., Iacone, R., Vespasiano, F., Vannucchi, S., Onder, G., Galletti, F., Galeone, D., Bellisario, P., Di Lenarda, A., Giampaoli, S., Palmieri, L., and Strazzullo, P.
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Adult ,Male ,medicine.medical_specialty ,Potassium intake ,Time Factors ,Epidemiology ,Endocrinology, Diabetes and Metabolism ,Urinary system ,Potassium ,Sodium ,Adult population ,Nutritional Status ,Medicine (miscellaneous) ,chemistry.chemical_element ,030209 endocrinology & metabolism ,Urinalysis ,030204 cardiovascular system & hematology ,Recommended Dietary Allowances ,Diet Surveys ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,K na ratio ,medicine ,Humans ,Nutrition ,Aged ,Public health ,Creatinine ,Nutrition and Dietetics ,business.industry ,Potassium, Dietary ,Sodium, Dietary ,Middle Aged ,Diet ,Renal Elimination ,Cross-Sectional Studies ,Italy ,chemistry ,Female ,Cardiology and Cardiovascular Medicine ,business ,Demography - Abstract
Background and aims Low potassium intake, in addition to high sodium, has been associated with higher risk of hypertension and CVD. The Study assessed habitual potassium intake and sodium/potassium ratio of the Italian adult population from 2008 to 2012 to 2018–2019 based on 24-h urine collection, in the framework of the CUORE Project/MINISAL-GIRCSI/MENO SALE PIU’ SALUTE national surveys. Methods and results Data were from cross-sectional surveys of randomly selected age-and-sex stratified samples of resident persons aged 35–74 years in 10 (out of 20) Italian regions. Urinary electrolyte and creatinine measurements were performed in a central laboratory. Analyses considered 942 men and 916 women, examined in 2008–2012, and 967 men and 1010 women, examined in 2018–2019. In 2008–2012, the age-standardized mean of potassium intake (urinary potassium accounts for 70% of potassium intake) was 3147 mg (95% CI 3086–3208) in men and 2784 mg (2727–2841) in women, whereas in 2018–2019, it was 3043 mg (2968–3118) and 2561 mg (2508–2614) respectively. In 2008–2012, age-adjusted prevalence of persons with an adequate potassium intake (i.e. ≥ 3510 mg/day) was 31% (95% CI 28–34%) for men and 18% (16–21%) for women; in 2018–2019, it was 26% (23–29%) and 12% (10–14%) respectively. The sodium/potassium ratio significantly decreased both in men and women. Conclusions The average daily potassium intake of the Italian general adult population remains lower than the WHO and EFSA recommended level. These results suggest the need of a revision to strengthen initiatives for the promotion of an adequate potassium intake at the population level.
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- 2021
19. Prevalence and Correlates of Statin Underuse for Secondary Prevention of Cardiovascular Disease in Older Adults 65–79 Years of Age: The Italian Health Examination Survey 2008–2012
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Diego Vanuzzo, Cinzia Lo Noce, Giovanni Viscogliosi, Luigi Palmieri, Flavia Carle, Chiara Donfrancesco, and Simona Giampaoli
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Male ,0301 basic medicine ,Aging ,Pediatrics ,medicine.medical_specialty ,Statin ,medicine.drug_class ,Adult population ,Disease ,03 medical and health sciences ,Health examination ,0302 clinical medicine ,Risk Factors ,Activities of Daily Living ,Prevalence ,Secondary Prevention ,medicine ,Humans ,Practice Patterns, Physicians' ,Aged ,Secondary prevention ,business.industry ,Statin treatment ,Cross-Sectional Studies ,030104 developmental biology ,Italy ,Cardiovascular Diseases ,Female ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery - Abstract
Limited data are available on the prevalence and correlates of statin use for secondary cardiovascular (CV) prevention in the older adult population. We used data of older adults (65-79 years) with established atherosclerotic CV disease from the cross-sectional Italian Health Examination Survey 2008-2012 to address this issue. Lifestyles, CV risk factors, chronic diseases, and therapies were assessed using standardized procedures. A comprehensive geriatric assessment was performed to evaluate cognitive function, disability in basic activities of daily living/instrumental activities of daily living, mobility, and polypharmacy. Multiple regression analyses were performed to identify independent correlates of statin use. A total of 392 participants (mean age 72.1 ± 4.4 years, 61.5% men) were considered for this analysis. Coronary heart disease was identified in 67.1% of participants, cerebrovascular disease in 23.5%, and peripheral artery disease (PAD) in 18.1%. One hundred ninety (48.5%) were statin users. By multiple regression analysis, functional disability (odds ratio [OR] = 0.81; 95% confidence interval [CI] = 0.71-0.92
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- 2020
20. Challenges and opportunities in establishing an Health Examination Survey
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Chiara Donfrancesco, Diego Vanuzzo, Luigi Palmieri, Cinzia Lo Noce, and Simona Giampaoli
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lcsh:R5-920 ,education.field_of_study ,Medical education ,Notice ,business.industry ,lcsh:Public aspects of medicine ,Population ,Sampling (statistics) ,lcsh:RA1-1270 ,Documentation ,Nursing ,Informed consent ,External quality assessment ,health examination survey ,epidemiologic measurements ,standardization ,population surveillance ,quality assurance ,Medicine ,Survey data collection ,lcsh:Medicine (General) ,business ,education ,Quality assurance - Abstract
In Italy, the last 30 years witnessed the implementation of cross-sectional surveys providing baseline data on numerous risk factors collected from random samples of the adult general population. In order to support those groups who would like to implement an health examination survey (HES), according to the experience of the CUORE Project surveys, the objective of this paper is to describe some information related to the organization of a survey (examination sites and sampling, selection of analytic laboratory, coordination and personnel involved, sample selection, recruitment and appointment scheduling, informative notice and informed consent, participation rate, non-participation bias, quality assurance, survey data, long term storage of the samples, internal quality control, external quality assessment, feedback to participants, error checking, correction and documentation of the data, transfer and storage of the data, statistical analyses and interpretation of results, dissemination of results), usually shortly described in scientific papers but relevant when an HES is planned.
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- 2022
21. Quality Assessment of Healthcare Databases
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Simona Giampaoli, Rosaria Gesuita, Luigi Palmieri, Lidia Di Minco, Flavia Carle, Giovanni Corrao, and Edlira Skrami
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lcsh:R5-920 ,Government ,Database ,Computer science ,business.industry ,Quality assessment ,lcsh:Public aspects of medicine ,0211 other engineering and technologies ,lcsh:RA1-1270 ,02 engineering and technology ,computer.software_genre ,Toolbox ,Field (computer science) ,03 medical and health sciences ,0302 clinical medicine ,Data quality ,021105 building & construction ,Health care ,030212 general & internal medicine ,lcsh:Medicine (General) ,business ,computer ,Dissemination - Abstract
The assessment of data quality and suitability plays an important role in improving the validity and generalisability of the results of studies based on secondary use of health databases. The availability of more and more updated and valid information on data quality and suitability provides data users and researchers an useful tool to optimize their activities. In this paper, we have summarized and synthesized the main aspects of Data Quality Assessment (DQA) applied in the field of secondary use of healthcare databases, with the aim of drawing attention to the critical aspects having to be considered and developed for improving the correct and effective use of secondary sources. Four developing features are identified: standardizing DQA methods, reporting DQA methods and results, synergy between data managers and data users, role of Institutions. Interdisciplinarity, multi-professionality and connection between government institutions, regulatory bodies, universities and the scientific community will provide the "toolbox" for i) developing standardized and shared DQA methods for health databases, ii) defining the best strategies for disseminating DQA information and results.
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- 2022
22. The Determinants of Vaccine Literacy in the Italian Population: Results from the Health Literacy Survey 2019
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Chiara Cadeddu, Luca Regazzi, Guglielmo Bonaccorsi, Aldo Rosano, Brigid Unim, Robert Griebler, Thomas Link, Paola De Castro, Roberto D’Elia, Valeria Mastrilli, and Luigi Palmieri
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Adult ,Practice ,Health Knowledge, Attitudes, Practice ,Vaccines ,attitudes ,health promotion ,Health, Toxicology and Mutagenesis ,Health Knowledge ,Vaccination ,Public Health, Environmental and Occupational Health ,vaccination hesitancy ,COVID-19 ,Health Literacy ,Cross-Sectional Studies ,Italy ,information-seeking behavior ,health literacy ,vaccination ,health knowledge ,practice ,surveys and questionnaires ,Surveys and Questionnaires ,Humans ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,Pandemics - Abstract
Vaccines are among the most important public health achievements of the last century; however, vaccine awareness and uptake still face significant challenges and the COVID-19 pandemic has only exacerbated this phenomenon. Vaccine Literacy (VL) is the ability to find, understand and judge immunisation-related information to make appropriate immunisation decisions. A cross-sectional study on a sample of 3500 participants, representative of the Italian adult population aged 18+ years, was conducted in Italy in 2021. A validated questionnaire, including sections on health literacy (HL), sociodemographic characteristics, risk factors, and lifestyles of respondents, was used. VL was measured by four items (item 19, 22, 26 and 29) of the HL section. While 67.6% of the respondents had a “good” (47.5%) or “sufficient” (20.1%) level of VL, 32.4% had “limited” VL levels. Although the overall VL level was quite high, many participants reported difficulties in dealing with vaccination information, particularly those with a lower educational level, those living in southern and insular regions of Italy, those with greater financial deprivation and those with a migration background. Improving VL in Italy should be a top priority in the political agenda, with special regard to socially and geographically disadvantaged communities.
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- 2022
23. Coronavirus-Related Health Literacy: A Cross-Sectional Study during the COVID-19 Pandemic in Italy
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Aldo Rosano, Chiara Lorini, Brigid Unim, Robert Griebler, Chiara Cadeddu, Luca Regazzi, Daniela Galeone, and Luigi Palmieri
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Adult ,Attitudes and practices ,COVID-19 ,Health literacy ,Italy ,Knowledge ,Risk factors ,Risk perception ,knowledge ,SARS-CoV-2 ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,attitudes and practices ,Health Literacy ,health literacy ,risk perception ,risk factors ,Cross-Sectional Studies ,Humans ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,Pandemics - Abstract
The COVID-19 pandemic has caused an overabundance of valid and invalid information to spread rapidly via traditional media as well as by internet and digital communication. Health literacy (HL) is the ability to access, understand, appraise, and apply health information, making it fundamental for finding, interpreting, and correctly using COVID-19 information. A cross-sectional study of a sample of 3500 participants representative of the Italian adult population aged 18+ years was conducted in Italy in 2021. A validated HL questionnaire was employed, including sections on coronavirus-related HL, general HL, sociodemographic characteristics, risk factors, and respondents’ lifestyle. Of our sample, 49.3% had “excellent” levels of coronavirus-related HL and 50.7% had “sufficient” (20.7%) or “limited” (30.0%) levels. Although the overall HL-COVID level was high, many participants reported difficulties dealing with COVID-19 information; in particular, participants older than 65 years, with a low education level, living in southern regions of Italy, and with high financial deprivation. Targeted public information campaigns and the promotion of HL are required for better navigation of health information environments. The COVID-19 pandemic has highlighted the need to improve HL and to prepare the general population for future emergency and non-emergency situations, confirming that HL can be considered a social vaccine.
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- 2022
24. Mitochondrial transport and metabolism of the vitamin B-derived cofactors thiamine pyrophosphate, coenzyme A, FAD and NAD
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Ferdinando, Palmieri, Magnus, Monné, Giuseppe, Fiermonte, and Luigi, Palmieri
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Flavin-Adenine Dinucleotide ,Coenzyme A ,Vitamins ,Thiamine Pyrophosphate ,NAD - Abstract
Multiple mitochondrial matrix enzymes playing key roles in metabolism require cofactors for their action. Due to the high impermeability of the mitochondrial inner membrane, these cofactors need to be synthesized within the mitochondria or be imported, themselves or one of their precursors, into the organelles. Transporters belonging to the protein family of mitochondrial carriers have been identified to transport the coenzymes: thiamine pyrophosphate, coenzyme A, FAD and NAD
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- 2022
25. Praseodymium trivalent ion is an effective inhibitor of mitochondrial basic amino acids and carnitine/acylcarnitine carriers
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Giovanna Incampo, Nicola Giangregorio, Nicola Gambacorta, Orazio Nicolotti, Concetta Pacifico, Luigi Palmieri, and Annamaria Tonazzi
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Inhibitor ,Liposomes ,Mitochondria ,Praseodymium ,Reconstitution ,Slc25 family transporters ,Transport ,Mitochondrial Proteins ,Carnitine Acyltransferases ,Amino Acids, Basic ,Carnitine ,Biophysics ,Humans ,Cell Biology ,cardiovascular diseases ,Biochemistry ,Mitochondrial Membrane Transport Proteins - Abstract
hondrial transporters for basic amino acids and phylogenetically related carriers belonging to the Slc25 family. The inhibitory effect of Pr3+ has been tested using mitochondrial transporters reconstituted into liposomes being effective in the micromolar range, acting as a competitive inhibitor of the human basic amino acids carrier (BAC, Slc25A29), the human carnitine/acylcarnitine carrier (CAC, Slc25A20). Furthermore, we provide computational evidence that the complete inhibition of the transport activity of the recombinant proteins is due to the Pr3+ coordination to key acidic residues of the matrix salt bridge network. Besides being used as a first choice stop inhibitor for functional studies in vitro of mitochondrial carriers reconstituted in proteoliposomes, Pr3+ might also represent a useful tool for structural studies of the mitochondrial carrier family.
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- 2022
26. Trends in cardiovascular diseases burden and vascular risk factors in Italy: The Global Burden of Disease study 1990–2017
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Paul S Briant, Luigi Palmieri, Paolo Cortesi, Carla Fornari, Giuseppe Remuzzi, Gregory A. Roth, Minh Nguyen, Simona Giampaoli, Giampiero Mazzaglia, Sara Conti, Norberto Perico, Giacomo Crotti, Francesco Profili, Lorenzo Monasta, Catherine O. Johnson, Simon Yadgir, Eugenio Traini, Lorenzo G. Mantovani, Fabio Voller, Boris Bikbov, Valeria Caso, Fabiana Madotto, Mohsen Naghavi, Cortesi, P, Fornari, C, Madotto, F, Conti, S, Naghavi, M, Bikbov, B, Briant, P, Caso, V, Crotti, G, Johnson, C, Nguyen, M, Palmieri, L, Perico, N, Profili, F, Remuzzi, G, Roth, G, Traini, E, Voller, F, Yadgir, S, Mazzaglia, G, Monasta, L, Giampaoli, S, and Mantovani, L
- Subjects
Burden of disease ,medicine.medical_specialty ,Epidemiology ,prevalence ,burden of disease ,030204 cardiovascular system & hematology ,Vascular risk ,Global Health ,Global Burden of Disease ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,risk factors ,Disability-adjusted life year ,030212 general & internal medicine ,Intensive care medicine ,Disease burden ,Estimation ,disability-adjusted life year ,business.industry ,Disability-Adjusted Life Years ,Cardiovascular disease ,mortality ,Cardiovascular Diseases ,Quality-Adjusted Life Years ,Cardiology and Cardiovascular Medicine ,business - Abstract
Aims An exhaustive and updated estimation of cardiovascular disease burden and vascular risk factors is still lacking in European countries. This study aims to fill this gap assessing the global Italian cardiovascular disease burden and its changes from 1990 to 2017 and comparing the Italian situation with European countries. Methods All accessible data sources from the 2017 Global Burden of Disease study were used to estimate the cardiovascular disease prevalence, mortality and disability-adjusted life years and cardiovascular disease attributable risk factors burden in Italy from 1990 to 2017. Furthermore, we compared the cardiovascular disease burden within the 28 European Union countries. Results Since 1990, we observed a significant decrease of cardiovascular disease burden, particularly in the age-standardised prevalence (–12.7%), mortality rate (–53.8%), and disability-adjusted life years rate (–55.5%). Similar improvements were observed in the majority of European countries. However, we found an increase in all-ages prevalence of cardiovascular diseases from 5.75 m to 7.49 m Italian residents. Cardiovascular diseases still remain the first cause of death (34.8% of total mortality). More than 80% of the cardiovascular disease burden could be attributed to known modifiable risk factors such as high systolic blood pressure, dietary risks, high low density lipoprotein cholesterol, and impaired kidney function. Conclusions Our study shows a decline in cardiovascular mortality and disability-adjusted life years, which reflects the success in reducing disability, premature death and early incidence of cardiovascular diseases. However, the burden of cardiovascular diseases is still high. An approach that includes the cooperation and coordination of all stakeholders of the Italian National Health System is required to further reduce this burden.
- Published
- 2020
27. Human motion trajectory prediction: a survey
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Andrey Rudenko, Luigi Palmieri, Dariu M. Gavrila, Kris M. Kitani, Kai O. Arras, and Michael Herman
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FOS: Computer and information sciences ,Computer Science - Machine Learning ,0209 industrial biotechnology ,Computer science ,Computer Vision and Pattern Recognition (cs.CV) ,Computer Science - Computer Vision and Pattern Recognition ,Spec# ,02 engineering and technology ,Machine Learning (cs.LG) ,Computer Science - Robotics ,020901 industrial engineering & automation ,Artificial Intelligence ,Motion prediction ,0202 electrical engineering, electronic engineering, information engineering ,Computer vision ,Electrical and Electronic Engineering ,computer.programming_language ,business.industry ,Applied Mathematics ,Mechanical Engineering ,Robotics ,Human motion ,Modeling and Simulation ,Trajectory ,020201 artificial intelligence & image processing ,Artificial intelligence ,business ,Robotics (cs.RO) ,computer ,Software - Abstract
With growing numbers of intelligent autonomous systems in human environments, the ability of such systems to perceive, understand and anticipate human behavior becomes increasingly important. Specifically, predicting future positions of dynamic agents and planning considering such predictions are key tasks for self-driving vehicles, service robots and advanced surveillance systems. This paper provides a survey of human motion trajectory prediction. We review, analyze and structure a large selection of work from different communities and propose a taxonomy that categorizes existing methods based on the motion modeling approach and level of contextual information used. We provide an overview of the existing datasets and performance metrics. We discuss limitations of the state of the art and outline directions for further research., Comment: Submitted to the International Journal of Robotics Research (IJRR), 37 pages
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- 2020
28. Association Between Antidepressant Medication Use and Prevalence and Control of Cardiovascular Risk Factors in Community-Dwelling Older Adults: The Italian Health Examination Survey 2008–2012
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Chiara Donfrancesco, Diego Vanuzzo, Giovanni Viscogliosi, Simona Giampaoli, Luigi Palmieri, Flavia Carle, and Cinzia Lo Noce
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Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Cardiovascular risk factors ,Population ,Risk Assessment ,Health examination ,Prevalence ,Internal Medicine ,medicine ,Humans ,Healthy Lifestyle ,Psychiatry ,Association (psychology) ,education ,Aged ,Medication use ,education.field_of_study ,Depression ,business.industry ,Age Factors ,Protective Factors ,Antidepressive Agents ,Drug Utilization ,Antidepressant medication ,Cross-Sectional Studies ,Italy ,Cardiovascular Diseases ,Heart Disease Risk Factors ,Antidepressant ,Female ,Independent Living ,business ,Risk Reduction Behavior - Abstract
Background: To assess the association of antidepressant (AD) medication use with prevalence and control of cardiovascular (CV) risk factors. Methods: Data of older adults from the population-based ...
- Published
- 2020
29. CIAO⁎: MPC-based Safe Motion Planning in Predictable Dynamic Environments
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Per Rutquist, Moritz Diehl, Kai O. Arras, Luigi Palmieri, Tobias Schoels, and Andrea Zanelli
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0209 industrial biotechnology ,Mathematical optimization ,Computer science ,020208 electrical & electronic engineering ,Regular polygon ,02 engineering and technology ,Function (mathematics) ,Workspace ,Motion (physics) ,Computer Science::Robotics ,Model predictive control ,020901 industrial engineering & automation ,Control and Systems Engineering ,0202 electrical engineering, electronic engineering, information engineering ,Robot ,Motion planning ,Collision avoidance - Abstract
Robots have been operating in dynamic environments and shared workspaces for decades. Most optimization based motion planning methods, however, do not consider the movement of other agents, e.g. humans or other robots, and therefore do not guarantee collision avoidance in such scenarios. This paper builds upon the Convex Inner ApprOximation (CIAO) method and proposes a motion planning algorithm that guarantees collision avoidance in predictable dynamic environments. Furthermore, it generalizes CIAO’s free region concept to arbitrary norms and proposes a cost function to approximate time optimal motion planning. The proposed method, CIAO*, finds kinodynamically feasible and collision free trajectories for constrained single body robots using model predictive control (MPC). It optimizes the motion of one agent and accounts for the predicted movement of surrounding agents and obstacles. The experimental evaluation shows that CIAO* reaches close to time optimal behavior.
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- 2020
30. The Impact of a Training Intervention on Detection of Patient-Ventilator Asynchronies in Nursing Students
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Francesco, Gravante, Franco, Crisci, Luigi, Palmieri, Luciano, Cecere, Cristian, Fusi, Enrico, Bulleri, Luigi, Pisani, and Stefano, Bambi
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Ventilators, Mechanical ,Critical Care ,Humans ,Students, Nursing ,Clinical Competence ,Respiration, Artificial - Abstract
Patient-ventilator asynchronies (PVA) are associated to negative outcomes for patients: increased respiratory work, mechanical ventilation time and ICU length of stay, and mortality. Some studies described the positive impact of a training intervention on the knowledge and attitudes of nurses in detecting PVA. The aim of this study was to evaluate the efficacy of a training intervention focused on detection of PVA.A before-after design on a single group of nursing students was used. The training intervention about detection of the correct respiratory waveform through graphic monitoring was conducted in a single edition course of 2 hours, for 25 participants. Measurements of correct detection of PVA through specific competency assessment tool were performed before (T0), immediately after (T1) and at 1 month (T2) from the training intervention between January and February 2020.19 Nurse students completed the training. A total of 50 questionnaires were distributed (T0; n=19; T1; n=19; T2; n=12). PVA were correctly detected in 67.5% (77) of cases. Statistically significant difference There were differences in trainees performance between T0 and T1 [77,2% (CI95%: 68,7% - 85,8%; p=0.001)] and between T0 and T2 [75% (CI95%: 65,3% - 84,7%; p=0.001]. No significant difference was recorded between T1 and T2 (p=0.83) Conclusions: Nursing students increased their performance on analysis of the graphic monitoring of the respiratory waveforms and detection of asynchronies after a basic training intervention. These skills were retained after 1 month. Nurse student trained about PVA increased their competence potentially employed in critical care settings.
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- 2021
31. Overview of national health reporting in the EU and quality criteria for public health reports – results of the Joint Action InfAct
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A Fehr, M Tijhuis, P Achterberg, Brigid Unim, Luigi Palmieri, Martin Thissen, Thomas Ziese, and Stefanie Seeling
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National health ,medicine.medical_specialty ,business.industry ,media_common.quotation_subject ,Public health ,Research ,Public Health, Environmental and Occupational Health ,Dissemination ,Public relations ,Recommendations ,Reporting format ,Joint action ,Public health report ,Health information ,medicine ,Health reporting ,Quality criteria ,Quality (business) ,Public aspects of medicine ,RA1-1270 ,Inequalities ,business ,Target group ,media_common - Abstract
Background Health reporting shall provide up-to-date health-related data to inform policy-makers, researchers and the public. To this end, health reporting formats should be tailored to the needs and competencies of the target groups and provide comparable and high-quality information. Within the Joint Action on Health Information ‘InfAct’, we aimed at gaining an overview of health reporting practices in the EU Member States and associated countries, and developed quality criteria for the preparation of public health reports. The results are intended to facilitate making health information adequately available while reducing inequalities in health reporting across the EU. Methods A web-based desk research was conducted among EU Member States and associated countries to generate an overview of different formats of national health reporting and their respective target groups. To identify possible quality criteria for public health reports, an exploratory literature review was performed and earlier projects were analysed. The final set of criteria was developed in exchange with experts from the InfAct consortium. Results The web-based desk research showed that public health reports are the most frequently used format across countries (94%), most often addressed to scientists and researchers (51%), politicians and decision-makers (41%). However, across all reporting formats, the general public is the most frequently addressed target group. With regards to quality criteria for public health reports, the literature review has yielded few results. Therefore, two earlier projects served as main sources: the ‘Evaluation of National and Regional Public Health Reports’ and the guideline ‘Good Practice in Health Reporting‘from Germany. In collaboration with experts, quality criteria were identified and grouped into eight categories, ranging from topic selection to presentation of results, and compiled in a checklist for easy reference. Conclusion Health reporting practices in the EU are heterogeneous across Member States. The assembled quality criteria are intended to facilitate the preparation, dissemination and access to better comparable high-quality public health reports as a basis for evidence-based decision-making. A comprehensive conceptual and integrative approach that incorporates the policy perspective would be useful to investigate which dissemination strategies are the most suitable for specific requirements of the targeted groups.
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- 2021
32. Clinical characteristics of SARS-CoV-2 fully-vaccinated patients dying with COVID-19 in Italy
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Luigi Palmieri, Marco Floridia, Marina Giuliano, Dorina Tiple, Cinzia Lo Noce, Paola Meli, and Graziano Onder
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Microbiology (medical) ,Infectious Diseases ,Italy ,SARS-CoV-2 ,Health Personnel ,Vaccination ,COVID-19 ,Humans ,General Medicine - Published
- 2021
33. Trends of blood pressure, raised blood pressure, hypertension and its control among Italian adults: CUORE Project cross-sectional health examination surveys 1998/2008/2018
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Chiara Donfrancesco, Anna Di Lonardo, Cinzia Lo Noce, Brigitta Buttari, Elisabetta Profumo, Francesca Vespasiano, Serena Vannucchi, Ferruccio Galletti, Graziano Onder, Michele Massimo Gulizia, Daniela Galeone, Paolo Bellisario, and Luigi Palmieri
- Subjects
Adult ,Male ,Cross-Sectional Studies ,Hypertension ,Prevalence ,Humans ,Female ,Blood Pressure ,General Medicine ,Health Surveys ,Antihypertensive Agents - Abstract
ObjectivesTo assess in the Italian general adult population the trends of blood pressure (BP) and prevalence of raised BP (RBP), hypertension and its control in order to evaluate population health and care, and the achievement of an RBP 25% relative reduction as recommended by the WHO at population level.DesignResults comparison of health examination surveys, cross-sectional observational studies based on health examination of randomly selected age and sex stratified samples including residents aged 35–74 years. Data of the 2018/2019 survey were compared with the previous ones collected in 1998/2002 and 2008/2012.SettingHealth examination surveys conducted in Italy within the CUORE Project following standardised methodologies.Participants2985 men and 2955 women examined in 1998/2002, 2218 men and 2204 women examined in 2008/2012 and 1031 men and 1066 women examined in 2018/2019.Primary and secondary outcome measuresAge-standardised mean of BP, prevalence of RBP (systolic BP and/or diastolic BP ≥140/90 mm Hg), hypertension (presenting or being treated for RBP) and its awareness and control, according to sex, age class and educational level.ResultsIn 2018/2019, a significant reduction was observed in systolic BP and diastolic BP in men (1998/2002: 136/86 mm Hg; 2008/2012: 132/84 mm Hg; and 2018/2019: 132/78 mm Hg) and women (132/82 mm Hg, 126/78 mm Hg and 122/73 mm Hg), and in the prevalence of RBP (50%, 40% and 30% in men and 39%, 25% and 16% in women) and of hypertension (54%, 49% and 44% in men and 45%, 35% and 32% in women). Trends were consistent by age and education attainment. In 2018/2019, hypertensive men and women with controlled BP were only 27% and 41%, but a significant favourable trend was observed.ConclusionsData from 2018/2019 underlined that RBP is still commonly observed in the Italian population aged 35–74 years, however, the WHO RBP target at that time may be considered met.
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- 2022
34. Trends of overweight, obesity and anthropometric measurements among the adult population in Italy: The CUORE Project health examination surveys 1998, 2008, and 2018
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Chiara Donfrancesco, Elisabetta Profumo, Cinzia Lo Noce, Daniela Minutoli, Anna Di Lonardo, Brigitta Buttari, Francesca Vespasiano, Serena Vannucchi, Ferruccio Galletti, Graziano Onder, Furio Colivicchi, Daniela Galeone, Paolo Bellisario, and Luigi Palmieri
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Adult ,Male ,Multidisciplinary ,Italy ,Prevalence ,Humans ,Female ,Obesity ,Overweight ,Noncommunicable Diseases ,Health Surveys ,Body Mass Index - Abstract
Background/Objectives Obesity is associated with an increased risk of noncommunicable diseases, such as diabetes, coronary heart disease, stroke, cancers, and conditions, including obstructive sleep apnea and osteoarthritis. Obesity is largely preventable, and halting its rise is one of the World Health Organization Global Action Plan for the Prevention of Noncommunicable Diseases targets. This study aimed to assess trends of anthropometric measurements in Italy using the data collected within the CUORE Project health examination surveys (HESs) 1998, 2008, and 2018. Subjects/Methods Within the HESs 1998–2002, 2008–2012, and 2018–2019, anthropometric measurements were collected in random samples of the resident population aged 35–74 years, stratified by age and sex, from 10 Italian Regions in Northern, Central, and Southern Italy (2984 men and 2944 women, 2224 men and 2188 women, 1035 men and 1065 women, respectively). Weight, height, and waist and hip circumferences were measured using standardized methodologies. A standardized questionnaire was used to collect data on education. Indicators were age standardized. Results For both men and women, mean body mass index in 2018 was comparable with those in 1998 and 2008 (in 1998, 2008, and 2018—men: 26.7, 27.5, and 27.0 kg/m2; women: 26.2, 26.6, and 26.3 kg/m2). In 1998, 2008, 2018 prevalence of overweight resulted 49%, 47%, 46% in men and 33%, 32%, 28% in women respectively; prevalence of obesity resulted 17%, 24% 20% in men and 19%, 23%, 23% in women respectively. All indicators of excess weight worsen with increasing age and are more severe in persons with a lower educational level. Conclusions Although the overall trend of excess weight over the past two decades appeared to be substantially stable in the Italian adult population, the continuous strengthening of undertaken initiatives should continue since there remains a high proportion of overweight or obesity and a gap between educational levels.
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- 2021
35. Impaired mitochondrial respiration in neuron progenitor cells from IPSCs of patients affected by AGC1 deficiency
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Francesco M. Lasorsa, Maria C. Magnifico, Simona N. Barile, Felix Distelmaier, Luigi Viggiano, Sabrina Petralla, Vito Porcelli, Antonella Pignataro, Eleonora Poeta, Isabella Pisano, Giuseppe Fiermonte, Luigi Palmieri, Stewart A. Anderson, Douglas C. Wallace, Julia Hentschel, and Barbara Monti
- Subjects
Biophysics ,Cell Biology ,Biochemistry - Published
- 2022
36. Mutations in SLC25A36 (PNC2) associated with the hyperinsulinism/hyperammonemia (HI/HA) syndrome
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Luigi Palmieri, Francesco M. Lasorsa, and Orly Elpeleg
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Biophysics ,Cell Biology ,Biochemistry - Published
- 2022
37. Citrate Regulates the Saccharomyces cerevisiae Mitochondrial GDP/GTP Carrier (Ggc1p) by Triggering Unidirectional Transport of GTP
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Roberta Seccia, Silvia De Santis, Maria A. Di Noia, Ferdinando Palmieri, Daniela V. Miniero, Raffaele Marmo, Eleonora Paradies, Antonella Santoro, Ciro L. Pierri, Luigi Palmieri, Carlo M. T. Marobbio, and Angelo Vozza
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Microbiology (medical) ,citrate ,GDP/GTP carrier ,GTP ,Fe-S centers ,membrane transport ,mitochondria ,mitochondrial carrier ,Plant Science ,Ecology, Evolution, Behavior and Systematics - Abstract
The yeast mitochondrial transport of GTP and GDP is mediated by Ggc1p, a member of the mitochondrial carrier family. The physiological role of Ggc1p in S. cerevisiae is probably to transport GTP into mitochondria in exchange for GDP generated in the matrix. ggc1Δ cells exhibit lower levels of GTP and increased levels of GDP in mitochondria, are unable to grow on nonfermentable substrates and lose mtDNA. Because in yeast, succinyl-CoA ligase produces ATP instead of GTP, and the mitochondrial nucleoside diphosphate kinase is localized in the intermembrane space, Ggc1p is the only supplier of mitochondrial GTP required for the maturation of proteins containing Fe-S clusters, such as aconitase [4Fe-4S] and ferredoxin [2Fe-2S]. In this work, it was demonstrated that citrate is a regulator of purified and reconstituted Ggc1p by trans-activating unidirectional transport of GTP across the proteoliposomal membrane. It was also shown that the binding site of Ggc1p for citrate is different from the binding site for the substrate GTP. It is proposed that the citrate-induced GTP uniport (CIGU) mediated by Ggc1p is involved in the homeostasis of the guanine nucleotide pool in the mitochondrial matrix.
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- 2022
38. Cross-national comparisons of health indicators require standardized definitions and common data sources
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Hanna Tolonen, Jaakko Reinikainen, Päivikki Koponen, Hanna Elonheimo, Luigi Palmieri, Mariken J. Tijhuis, and for the Joint Action on Health Information (InfAct)
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medicine.medical_specialty ,Standardization ,Environmental health ,Health care ,Comparability ,Medicine ,Social determinants of health ,Obesity ,Health policy ,business.industry ,Public health ,Research ,Diabetes ,Public Health, Environmental and Occupational Health ,Health services research ,International health ,medicine.disease ,Health indicator ,Asthma ,Geography ,Health promotion ,Health information ,Indicator ,Hypertension ,Public aspects of medicine ,RA1-1270 ,business ,Cross national - Abstract
Background Health indicators are used to monitor the health status and determinants of health of the population and population sub-groups, identify existing or emerging health problems which would require prevention and health promotion activities, help to target health care resources in the most adequate way as well as for evaluation of the success of public health actions both at the national and international level. The quality and validity of the health indicator depends both on available data and used indicator definition. In this study we will evaluate existing knowledge about comparability of different data sources for definition of health indicators, compare how selected health indicators presented in different international databases possibly differ, and finally, present the results from a case study from Finland on comparability of health indicators derived from different data sources at national level. Methods For comparisons, four health indicators were selected that were commonly available in international databases and available for the Finnish case study. These were prevalence of obesity, hypertension, diabetes, and asthma in the adult populations. Our evaluation has three parts: 1) a scoping review of the latest literature, 2) comparison of the prevalences presented in different international databases, and 3) a case study using data from Finland. Results Literature shows that comparability of estimated outcomes for health indicators using different data sources such as self-reported questionnaire data from surveys, measured data from surveys or data from administrative health registers, varies between indicators. Also, the case study from Finland showed that diseases which require regular health care visits such as diabetes, comparability is high while for health outcomes which can remain asymptomatic for a long time such as hypertension, comparability is lower. In different international health related databases, country specific results differ due to variations in the used data sources but also due to differences in indicator definitions. Conclusions Reliable comparison of the health indicators over time and between regions within a country or across the countries requires common indicator definitions, similar data sources and standardized data collection methods.
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- 2021
39. Comparison of metabolic syndrome prevalence using four different definitions - a population-based study in Finland
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Elsi Haverinen, Laura Paalanen, Luigi Palmieri, Alicia Padron-Monedero, Isabel Noguer-Zambrano, Rodrigo Sarmiento Suárez, Hanna Tolonen, for the Joint Action on Health Information (InfAct), and Unión Europea
- Subjects
Population health survey ,Research ,Health examination survey ,Diabetes ,Public Health, Environmental and Occupational Health ,nutritional and metabolic diseases ,Indicators ,Public aspects of medicine ,RA1-1270 ,Metabolic syndrome ,Standardization - Abstract
Background Metabolic syndrome (MetS) is a public health problem in Europe, affecting all age groups. Several MetS definitions are available. The aim of this study was to compare four different MetS definitions in the Finnish adult population, to assess their agreement and to evaluate the impact of the choice of the definition on the prevalence of MetS. Methods Data from FinHealth 2017, a cross-sectional national population health survey, focusing on adults aged 25 years or older were used in the analysis (n=5687). Measured data on anthropometrics, blood pressure and biomarkers together with questionnaire data were used to classify the participants into the MetS categories according to the four definitions. The definitions chosen for the comparison were those by the World Health Organization (WHO) (1998), National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) (2004), International Diabetes Federation (IDF) (2005), and Joint Interim Statement (JIS) (2009). Results The four MetS definitions resulted in substantially different MetS prevalence: 17.7% by WHO, 33.3% by NCEP-ATP III, 41.5% by IDF, and 43.0% by JIS. Regardless of the definition used, the prevalence of MetS increased with age. The prevalence of the different components varied between the definitions, depending on the different cut-off points adopted. Out of all participants, only 13.6% were identified to have MetS according to all four definitions. Agreement between participants recognised by different MetS definitions, estimated through kappa coefficients, was almost perfect for IDF vs. JIS (0.97), strong for JIS vs. NCEP-ATP III (0.80), moderate for IDF vs. NCEP-ATP III (0.76) and weak for WHO vs. NCEP-ATP III (0.42), WHO vs. IDF (0.41) and WHO vs. JIS (0.40). Conclusions Differences between observed prevalence of MetS in Finnish men and women using different MetS definitions were large. For cross-country comparisons, as well as for trend analyses within a country, it is essential to use the same MetS definition to avoid discrepancies in classification due to differences in used definitions.
- Published
- 2021
40. The mitochondrial citrate carrier in Yarrowia lipolytica: Its identification, characterization and functional significance for the production of citric acid
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Luigi Palmieri, S. P. Sineoky, Artem V. Shutov, Gennaro Agrimi, Iuliia M. Kosikhina, Tigran V. Yuzbashev, Elizaveta B. Vinogradova, Pasquale Scarcia, Evgeniya Y. Yuzbasheva, and Ferdinando Palmieri
- Subjects
0106 biological sciences ,Citric Acid Cycle ,Yarrowia ,Bioengineering ,Isocitric acid ,01 natural sciences ,Applied Microbiology and Biotechnology ,Tricarboxylate ,Fungal Proteins ,Mitochondrial Proteins ,03 medical and health sciences ,chemistry.chemical_compound ,010608 biotechnology ,Citrate synthase ,030304 developmental biology ,0303 health sciences ,biology ,Wild type ,Mitochondrial carrier ,biology.organism_classification ,Mitochondria ,Citric acid cycle ,chemistry ,Biochemistry ,biology.protein ,Aspergillus niger ,Carrier Proteins ,Citric acid ,Biotechnology - Abstract
Mitochondrial citrate carrier plays a central role in exporting acetyl-CoA in the form of citrate from mitochondria to cytosol thereby connecting carbohydrate catabolism and lipogenesis. In this study, Yarrowia lipolytica mitochondrial citrate carrier was functionally defined and characterized. Firstly, deletion of Y. lipolytica YlCTP1 and YlYHM2 genes coding putative tricarboxylate mitochondrial carriers were performed. ΔYlctp1 strain did not differ significantly from wild type strain in terms of growth rate, organic acids and lipid production. In contrast, ΔYlyhm2 strain did not grow in liquid citrate-containing minimal medium. Moreover, in glucose-containing lipogenic medium YlYHM2 null mutant strain did not produce citric acid; the production of isocitric acid and lipids were decreased. Reintroduction of YlYHM2 gene as well as heterologous expression of Aspergillus niger gene AnYHM2 into ΔYlyhm2 strain restored the growth in minimal citrate medium and even enhanced citric acid production by 45% in both variants compared with wild type strain during test tube cultivation. Mitochondrial extracts isolated from YlYHM2 null mutant and wild type strain were incorporated into liposomes; citrate/citrate and α-ketoglutarate/α-ketoglutarate homoexchange activities were reduced by 87% and 40% in ΔYlyhm2 strain, respectively, compared with the wild type, whereas citratein/α-ketoglutarateout and α-ketoglutaratein/citrateout heteroexchanges were decreased by 87% and 95%, respectively. YlYhm2p was expressed in Escherichia coli, purified and reconstituted into liposomes. Besides high efficiency to citrate and α-ketoglutarate transport, YlYhm2p also transported oxaloacetate, succinate, fumarate, and to a much lesser extent, aconitate, malate, isocitrate, oxoadipate, and glutamate. The activity of reconstituted YlYhm2p was inhibited strongly by SH-blocking reagents, pyridoxal-5′-phosphate, and partly by N-ethylmaleimide. Co-expression of YlYHM2 and adenosine monophosphate deaminase YlAMPD genes resulted in the production of 49.7 g/L of citric acid during test tube cultivation, whereas wild type strain accumulated 30.1 g/L of citric acid. Large-scale cultivation in bioreactor of the engineered strain resulted in 97.1 g/L of citric acid production with a process selectivity of 94.2% and an overall citric acid yield of 0.5 g/g. The maximal specific rate of citric acid synthesis was 0.93 g/L/h. Therefore, the physiological role of YlYhm2p in glucose-containing medium is to catalyze both import of citrate into mitochondria for catabolic reactions and export of citrate as a source of acetyl-CoA from mitochondria. Possible shuttles for citrate exporting are discussed. Moreover, for the first time evidence has been given for the improvement of TCA cycle intermediate production by manipulation of a gene coding a mitochondrial carrier.
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- 2019
41. Health inequalities: a Research Positioning Exercise at the National Institute of Health, Italy
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Raffaella Bucciardini, Tiziana Grassi, Chiara Donfrancesco, Letizia Sampaolo, Michela Sabbatucci, Loredana Falzano, Rita Maria Ferrelli, Annamaria Luzi, Stefano Buttò, Luigi Palmieri, Sandra Morelli, Rosanna Mancinelli, Simona Gaudi, Emanuela Bortolin, Walter Ricciardi, Roberto Pasetto, Paola De Castro, Anna Colucci, Anna Maria Giammarioli, Emanuele Fanales Belasio, and Benedetta Mattioli
- Subjects
Biomedical Research ,Evidence-based practice ,Inequality ,Social Determinants of Health ,media_common.quotation_subject ,evidence-based practice ,MEDLINE ,socioeconomic factors ,Vulnerable Populations ,Education ,Government Agencies ,Risk Factors ,Multidisciplinary approach ,Political science ,Humans ,Social determinants of health ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,Socioeconomic status ,media_common ,Medical education ,Arabidopsis Proteins ,Research ,Public Health, Environmental and Occupational Health ,Health Status Disparities ,Histone-Lysine N-Methyltransferase ,Italy ,Christian ministry ,Psychological resilience ,health disparity ,national health service - Abstract
Background The Italian National Institute of Health (Istituto Superiore di Sanità, ISS) considers health inequalities (HI) an important area of activity. As the scientific and technical body of the Ministry of Health and the National Health Service, ISS may play a key role to reduce HI. In order to enable ISS in addressing the new and crucial HI challenge, a Research Positioning Exercise was designed and implemented. Methods The Exercise included: (i) workshop to strengthen the institutional interest in the field of HI; (ii) review and analysis of ISS publications (years 2000–2017) to identify HI research topics; (iii) survey among ISS researchers regarding main research challenges to address HI in the coming years; and (iv) analysis of input on research challenges from HI international experts. Results The results of this Exercise suggest that the following points should be included in the future ISS agenda planning: (i) themes which ISS should continue working on (e.g. migrants/vulnerable groups); (ii) themes to be improved: (a) relationship between social determinants and mechanism of HI generation and (b) relationship between risk factors exposure and social determinants; and (iii) new themes to be addressed: (a) mechanisms underlying the resilience observed in Italy; (b) new socioeconomic indicators for HI monitoring; and (c) evidence-based policies aimed at reducing HI. Conclusion Findings of this Exercise show that ISS researchers identified relevant areas, addressing inequalities in addressing the health. Because of ISS structural peculiarity that includes multidisciplinary expertise, the ISS could provide a significant contribution to HI research challenges and knowledge gaps.
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- 2019
42. Evidence for Non-Essential Salt Bridges in the M-Gates of Mitochondrial Carrier Proteins
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Daniela Valeria Miniero, Magnus Monné, Maria Antonietta Di Noia, Luigi Palmieri, and Ferdinando Palmieri
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Protein Conformation, alpha-Helical ,Saccharomyces cerevisiae Proteins ,Amino Acid Motifs ,Organic Chemistry ,Saccharomyces cerevisiae ,General Medicine ,Mitochondrial Membrane Transport Proteins ,Catalysis ,Mitochondria ,Computer Science Applications ,Mitochondrial Proteins ,Inorganic Chemistry ,Mitochondrial Membranes ,Animals ,Cattle ,Physical and Theoretical Chemistry ,Molecular Biology ,GDP/GTP carrier ,membrane protein ,mitochondrial carrier ,NAD+ carrier ,oxoglutarate carrier ,transport mechanism ,site-directed mutagenesis ,solute carrier family 25 SLC25 ,substrate-transporter interactions ,Spectroscopy - Abstract
Mitochondrial carriers, which transport metabolites, nucleotides, and cofactors across the mitochondrial inner membrane, have six transmembrane α-helices enclosing a translocation pore with a central substrate binding site whose access is controlled by a cytoplasmic and a matrix gate (M-gate). The salt bridges formed by the three PX[DE]XX[RK] motifs located on the odd-numbered transmembrane α-helices greatly contribute to closing the M-gate. We have measured the transport rates of cysteine mutants of the charged residue positions in the PX[DE]XX[RK] motifs of the bovine oxoglutarate carrier, the yeast GTP/GDP carrier, and the yeast NAD+ transporter, which all lack one of these charged residues. Most single substitutions, including those of the non-charged and unpaired charged residues, completely inactivated transport. Double mutations of charged pairs showed that all three carriers contain salt bridges non-essential for activity. Two double substitutions of these non-essential charge pairs exhibited higher transport rates than their corresponding single mutants, whereas swapping the charged residues in these positions did not increase activity. The results demonstrate that some of the residues in the charged residue positions of the PX[DE]XX[KR] motifs are important for reasons other than forming salt bridges, probably for playing specific roles related to the substrate interaction-mediated conformational changes leading to the M-gate opening/closing.
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- 2022
43. Time trends in ischaemic heart disease incidence and mortality over three decades (1990-2019) in 20 Western European countries: systematic analysis of the Global Burden of Disease Study 2019
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Federico Vancheri, Lars Backlund, Luigi Palmieri, Chiara Donfrancesco, A. R. Tate, Michael Y. Henein, and Lars-Erik Strender
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Burden of disease ,medicine.medical_specialty ,Epidemiology ,business.industry ,Time trends ,Public health ,Incidence (epidemiology) ,Mortality rate ,Incidence ,Myocardial Ischemia ,Coronary Artery Disease ,Global Health ,Global Burden of Disease ,Income ,Medicine ,Humans ,Ischaemic heart disease ,Mortality ,Cardiology and Cardiovascular Medicine ,business ,Demography - Abstract
AimsTo investigate and compare changes in the rates of ischaemic heart disease (IHD) incidence and mortality between 1990 and 2019 in 20 high-income Western European countries with similar public health systems and low cardiovascular risk.Methods and resultsThe 2020 updated version of the Global Burden of Disease database was searched. Variability and differences in IHD incidence and mortality rates (per 100 000) between countries over time, were calculated. A piecewise linear (join point) regression model was used to identify the slopes of these trends and the points in time at which significant changes in the trends occur. Ischaemic heart disease incidence and mortality rates varied widely between countries but decreased for all between 1990 and 2019. The relative change was greater for mortality than for incidence. Ischaemic heart disease incidence rates declined by approximately 36% between 1990 and 2019, while mortality declined by approximately 60%. Breakpoint analysis showed that the largest decreases in incidence and mortality occurred between 1990 and 2009 (−32%, −52%, respectively), with a much slower decrease after that (−5.9%, −17.6%, respectively), and even a slight increase for some countries in recent years. The decline in both incidence and mortality was lower in the Mediterranean European countries compared to the Nordic and Central European regions.ConclusionsIn the Western European countries studied, the decline in age-standardized IHD incidence over three decades was slower than the decline in age-standardized IHD mortality. Decreasing trends of both IHD incidence and mortality has substantially slowed, and for some countries flattened, in more recent years.
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- 2021
44. A Yeast-Based Screening Unravels Potential Therapeutic Molecules for Mitochondrial Diseases Associated with Dominant
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Giulia, di Punzio, Maria Antonietta, Di Noia, Agnès, Delahodde, Carole, Sellem, Claudia, Donnini, Luigi, Palmieri, Tiziana, Lodi, and Cristina, Dallabona
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mitochondrial diseases ,Ophthalmoplegia ,Saccharomyces cerevisiae Proteins ,Adenine Nucleotide Translocator 1 ,yeast model ,Saccharomyces cerevisiae ,DNA, Mitochondrial ,Article ,High-Throughput Screening Assays ,Pharmaceutical Preparations ,Mutation ,Humans ,ANT1 mutations ,Mitochondrial ADP, ATP Translocases ,Genes, Dominant - Abstract
Mitochondrial diseases result from inherited or spontaneous mutations in mitochondrial or nuclear DNA, leading to an impairment of the oxidative phosphorylation responsible for the synthesis of ATP. To date, there are no effective pharmacological therapies for these pathologies. We performed a yeast-based screening to search for therapeutic drugs to be used for treating mitochondrial diseases associated with dominant mutations in the nuclear ANT1 gene, which encodes for the mitochondrial ADP/ATP carrier. Dominant ANT1 mutations are involved in several degenerative mitochondrial pathologies characterized by the presence of multiple deletions or depletion of mitochondrial DNA in tissues of affected patients. Thanks to the presence in yeast of the AAC2 gene, orthologue of human ANT1, a yeast mutant strain carrying the M114P substitution equivalent to adPEO-associated L98P mutation was created. Five molecules were identified for their ability to suppress the defective respiratory growth phenotype of the haploid aac2M114P. Furthermore, these molecules rescued the mtDNA mutability in the heteroallelic AAC2/aac2M114P strain, which mimics the human heterozygous condition of adPEO patients. The drugs were effective in reducing mtDNA instability also in the heteroallelic strain carrying the R96H mutation equivalent to the more severe de novo dominant missense mutation R80H, suggesting a general therapeutic effect on diseases associated with dominant ANT1 mutations.
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- 2021
45. Learning Occupancy Priors of Human Motion from Semantic Maps of Urban Environments
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Andrey Rudenko, Luigi Palmieri, Kai O. Arras, Achim J. Lilienthal, and Johannes Doellinger
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FOS: Computer and information sciences ,Control and Optimization ,Occupancy ,Generalization ,Computer science ,Biomedical Engineering ,02 engineering and technology ,010501 environmental sciences ,Machine learning ,computer.software_genre ,Semantics ,01 natural sciences ,Convolutional neural network ,Motion (physics) ,Computer Science - Robotics ,Artificial Intelligence ,11. Sustainability ,0202 electrical engineering, electronic engineering, information engineering ,0105 earth and related environmental sciences ,business.industry ,Mechanical Engineering ,Intelligent decision support system ,Robotics ,Computer Science Applications ,Human-Computer Interaction ,Control and Systems Engineering ,Trajectory ,020201 artificial intelligence & image processing ,Computer Vision and Pattern Recognition ,Artificial intelligence ,business ,computer ,Robotics (cs.RO) - Abstract
Understanding and anticipating human activity is an important capability for intelligent systems in mobile robotics, autonomous driving, and video surveillance. While learning from demonstrations with on-site collected trajectory data is a powerful approach to discover recurrent motion patterns, generalization to new environments, where sufficient motion data are not readily available, remains a challenge. In many cases, however, semantic information about the environment is a highly informative cue for the prediction of pedestrian motion or the estimation of collision risks. In this work, we infer occupancy priors of human motion using only semantic environment information as input. To this end we apply and discuss a traditional Inverse Optimal Control approach, and propose a novel one based on Convolutional Neural Networks (CNN) to predict future occupancy maps. Our CNN method produces flexible context-aware occupancy estimations for semantically uniform map regions and generalizes well already with small amounts of training data. Evaluated on synthetic and real-world data, it shows superior results compared to several baselines, marking a qualitative step-up in semantic environment assessment., Comment: 8 pages, final pre-print version of the IEEE RA-L letter
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- 2021
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46. Evolution of Pathology Patterns in Persons Who Died From COVID-19 in Italy: A National Study Based on Death Certificates
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Francesco Grippo, Enrico Grande, Alice Maraschini, Simone Navarra, Marilena Pappagallo, Stefano Marchetti, Roberta Crialesi, Luisa Frova, Chiara Orsi, Silvia Simeoni, Annamaria Carinci, Giuseppe Loreto, Chiara Donfrancesco, Cinzia Lo Noce, Luigi Palmieri, Xanthi Andrianou, Alberto Mateo Urdiales, Graziano Onder, Giada Minelli, and Italian National Institute of Health COVID-19 Mortality Group
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lcsh:R5-920 ,Pediatrics ,medicine.medical_specialty ,business.industry ,SARS-CoV-2 ,General Medicine ,Disease ,medicine.disease ,comorbidities ,Comorbidity ,mortality ,Hypertensive heart disease ,cause of death ,Respiratory failure ,Diabetes mellitus ,medicine ,surveillance ,Dementia ,Medicine ,lcsh:Medicine (General) ,business ,Disease burden ,Cause of death ,Original Research - Abstract
Background: In Italy, during the first epidemic wave of 2020, the peak of coronavirus disease 2019 (COVID-19) mortality was reached at the end of March. Afterward, a progressive reduction was observed until much lower figures were reached during the summer, resulting from the contained circulation of SARS-CoV-2. This study aimed to determine if and how the pathological patterns of the individuals deceased from COVID-19 changed during the phases of epidemic waves in terms of: (i) main cause of death, (ii) comorbidities, and (iii) complications related to death.Methods: Death certificates of persons who died and tested positive for SARS-CoV-2, provided by the National Surveillance system, were coded according to ICD rev10. Deaths due to COVID-19 were defined as those in which COVID-19 was the underlying cause of death.Results: The percentage of COVID-19 deaths varied over time. It decreased in the downward phase of the epidemic curve (76.6 vs. 88.7%). In February–April 2020, hypertensive heart disease was mentioned as a comorbidity in 18.5% of death certificates, followed by diabetes (15.9% of cases), ischemic heart disease (13.1%), and neoplasms (12.1%). In May–September, the most frequent comorbidity was neoplasms (17.3% of cases), followed by hypertensive heart disease (14.9%), diabetes (14.8%), and dementia/Alzheimer's disease (11.9%). The most mentioned complications in both periods were pneumonia and respiratory failure with a frequency far higher than any other condition (78.4% in February–April 2020 and 63.7% in May–September 2020).Discussion: The age of patients dying from COVID-19 and their disease burden increased in the May–September 2020 period. A more serious disease burden was observed in this period, with a significantly higher frequency of chronic pathologies. Our study suggests better control of the virus' lethality in the second phase of the epidemic, when the health system was less burdened. Moreover, COVID-19 care protocols had been created in hospitals, and knowledge about the diagnosis and treatment of COVID-19 had improved, potentially leading to more accurate diagnosis and better treatment. All these factors may have improved survival in patients with COVID-19 and led to a shift in mortality to older, more vulnerable, and complex patients.
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- 2020
47. Author response: Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight
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Zahra Mohammadi, Abdul Basit, Helena I. S. Nogueira, Soile E. Puhakka, Hongsheng Bi, Ari Voutilainen, Davood Khalili, Bin Zhou, Dermot O'Reilly, Natascia Rinaldo, Paulo A. Lotufo, Bahareh Kheiri, Thein Thein Htay, Simona Giampaoli, Goodarz Danaei, M. Fernanda Lima-Costa, Simona Bo, Peter Schnohr, Jerzy Chudek, Francesco Panza, Ling Yang, Katia Vergetti Bloch, Vincenzo Capuano, Holly E. Syddall, Dong Zhao, Indah Suci Widyahening, Maria Lorenza Muiesan, Leng Huat Foo, Mohsen Azimi-Nezhad, Merete Osler, Laura Torres-Collado, Manu Raj, Adroaldo Cesar Araujo Gaya, Susi Kriemler, Ali Akbar Shayesteh, Aneta Grajda, Anette Varbo, Kazem Mohammad, Leila Beltrami Moreira, Shu Ti Chiou, Iuliia A Rusakova, Jyh Eiin Wong, Torben Jørgensen, Lela Sturua, Lubica Ticha, Hamid Hakimi, Hazzaa M. Al-Hazzaa, Yanina Zócalo, Freda Pitakaka, Savvas C. Savva, Rajeev Gupta, Jennifer Servais, Marie Kunešová, Johanna M. Geleijnse, Elysée Claude Bika Lele, Yannis Manios, Jorge Escobedo-de la Peña, Yufang Bi, Chinh Nguyen Huu, Sibel Gogen, Viviane Cunha Cardoso, Kristine H. Allin, Ana Azevedo, Line Tang Møllehave, Vincent Jr DeGennaro, Novie O. Younger-Coleman, Gretchen A Stevens, Dickman Gareta, Holger Theobald, Anja Schienkiewitz, Bekbolat Zholdin, Janice Luisa Lukrafka, Adela Chirita-Emandi, Ulla Roggenbuck, Kenisha Russell Jonsson, Robespierre Ribeiro, Gabriele Eiben, Eero Kajantie, Sounnia Mediene Benchekor, Fariborz Mansour-Ghanaei, Mary Simon, Prakash C. Gupta, Mohammad Esmaeel Motlagh, Emanuela Gualdi-Russo, María Elena Díaz-Sánchez, Pilar Guallar-Castillón, Bee Koon Poh, Cristina Padez, Azaliia M Tuliakova, Sarah P. Garnett, William R. Tebar, Yingfeng Zheng, Suhad Bahijri, Christina Mavrogianni, Mihaela Vladulescu, Jan A. Staessen, Paula Duarte de Oliveira, Rui Ornelas, Michael Sjöström, Charles Agyemang, Slawomir Koziel, Shohreh Naderimagham, Jari Jokelainen, Stephen T. McGarvey, Patrick Pasquet, Farnam Mohebi, Nader Saki, Aida Pilav, Azim Nejatizadeh, Marianna Noale, Habiba Ben Romdhane, Luís B. Sardinha, Laura Lauria, Jun Hata, Kodanda R Kanala, Gert B. M. Mensink, Nils Lehmann, Elio Riboli, Carolina Tarqui-Mamani, Rodrigo M. Carrillo-Larco, Rosangela Fernandes Lucena Batista, Victoria E Soto-Rojas, Luis Serra-Majem, Martina Müller-Nurasyid, Felipe Vogt Cureau, Lekhraj Rampal, Zhamilya Battakova, Ludmila Sevcikova, Suhaila Abdul Ghaffar, Fikru Tullu, Aung Soe Htet, Angel R. Gonzalez, Annette J. Dobson, Kavumpurathu Raman Thankappan, Hélène Delisle, Francisco J. Félix-Redondo, Ramón Suárez-Medina, Annika Rosengren, Sania Nishtar, Tanja G. M. Vrijkotte, Wolfgang Ahrens, Osvaldo Santos, Maria Cecília Formoso Assunção, Kazi M. Jamil, Stefano Marventano, Wenbin Wei, Norsyamlina Che Abdul Rahim, Shukri F. Mohamed, Bente Sparboe-Nilsen, Soon-Woo Park, Ana Isabel Rito, David Goltzman, W. M. Monique Verschuren, Catterina Ferreccio, Marta Buoncristiano, Ramón Alberto Rascón-Pacheco, Pradeep Joshi, Edward D Janus, Laetitia Huiart, Ala'a Alkerwi, Lorenza Pilotto, Mohannad Al Nsour, Daan Kromhout, Marius B. Bjertness, Oanh T. H. Trinh, Nico Dragano, Angélica Ochoa-Avilés, Ingunn Holden Bergh, Yuki Fujita, Juraci Almeida Cesar, Hajer Aounallah-Skhiri, Maria Dorobantu, Jordi Sunyer, Wolfgang Kratzer, Susanne R. de Rooij, Drude Molbo, Rebecca Goldsmith, Jean Woo, Mohammad El-khateeb, Tiffany K. Gill, Nish Chaturvedi, Benjamin Acosta-Cazares, Erik Lykke Mortensen, Nikhil D. Patel, Francesco Pistelli, Yuan He, Ivana Radic, Yi Zeng, Ilse Khouw, Reynaldo Martorell, Ching-Yu Cheng, Stine Schramm, Hana Shimizu-Furusawa, Jacek Jóźwiak, Radwan Qasrawi, Isti Ilmiati Fujiati, Charles Sossa Jérome, Ben Schöttker, Mikhail Benet, Anastasia Markaki, Christopher T. Cowell, Bharathi Viswanathan, Renata Kuciene, Jose Eugenio Lozano, Pedro J Ortiz, Delphine De Smedt, Elaine M. Murtagh, Kamel Ajlouni, Carlos A. Aguilar-Salinas, Graziella D'Arrigo, Xiangjun Wang, Lars Lind, Macia Enguerran, Marjeta Mišigoj-Duraković, Bo Werner, Jean-Michel Gaspoz, Kyungwon Oh, Seyed Rasoul Zakavi, Daniel Fernández-Bergés, Felix Kaducu, Ramon O. Jimenez, Jonathan E. Shaw, Nipa Rojroongwasinkul, Aicha Soumare, Astrid Petersmann, Tomasz Grodzicki, Parvina Mukhtorova, Eha Nurk, Bhawesh Koirala, Óscar Lopes, Ana Jelakovic, Karolina Milkowska, Magda Gasull, Regina Heidinger-Felso, Marcela González-Gross, Belong Cho, Daphne Mirkopoulou, Salvador Villalpando, Tran Quoc Bao, José Boggia, Daniela Galeone, Josep Redon, Matthias Bopp, Abbas Rezaianzadeh, Dusko Bjelica, Amir Houshang Mehrparvar, Felipe F. Casanueva, Khairil Si-Ramlee, Soheir H Ahmed, Maria Nordendahl, Luciana Zaccagni, Mahboubeh Parsaeian, Rod Jackson, Jorge Motta, Keiu Nelis, Fernando Rigo, Andrzej Pajak, Christa Meisinger, Clara Homs, Namuna Shrestha, Mar Alvarez-Pedrerol, Xun Tang, Johann Willeit, Motahareh Kheradmand, Jean Dallongeville, Jean-Bernard Ruidavets, Anne Tjønneland, Diana A. Santos, Lynne M. Boddy, Jie Hao, David Alejandro González-Chica, Elin Kolle, Jingli Gao, Małgorzata Mossakowska, Isabel O. Oliveira, Giuseppe Grosso, Seongjun Ha, Olfa Saidi, Albina A Fakhretdinova, Oye Gureje, Raluca Pop, Iulia Jurca Simina, Nuno Lunet, Maria Forsner, Peter Bjerregaard, Rachael McLean, Antonio Cabrera de León, Guy De Backer, José A. Casajús, Guang Ning, Emmanuella Magriplis, Laura Censi, Graziella Bruno, Valentina Peterkova, Angelique Chan, Yvonne T. van der Schouw, Charalambos Hadjigeorgiou, Anjani Kumar Jha, Toomas Veidebaum, Thamara Hubler Figueiró, Jana Kratenova, Michelle Cilia, Ivo Rakovac, Bill Stavreski, Ya Xing Wang, Oscar Noboa, Romana Roccaldo, Sara Magnacca, Johan Sundström, Peter Stehle, Tania Lopez, Francis Delpeuch, Julianne Williams, Ellisiv B. Mathiesen, Leanne M. Riley, Claudia M. Hormiga, Joanne Katz, Ekaterina Stoyanova, Heloisa Bettiol, Gabriele Nagel, Alireza Khosravi, Lars Bo Andersen, João Breda, Jørgen Meisfjord, Ahmad Faudzi Yusoff, Marjeta Majer, Robert Beaglehole, Caleb Ochimana, Shynar Abdrakhmanova, George S. Stergiou, Blanca Sandra Ruiz-Betancourt, Leon A. Simons, Eng Joo Tan, Victoria Farrugia Sant'Angelo, Gry Skodje, Maryam Keramati, Liv Elin Torheim, Seppo Koskinen, Assembekov Batyrbek, Jaakko Tuomilehto, Marjo-Riitta Järvelin, Ming-Hui Zhao, Krista Fischer, Tobias F. Rinke de Wit, Agnès Le Port, Reza Homayounfar, James E. Bennett, Yuna He, Matsuda Fumihiko, Qi Sheng You, Angela Spinelli, Scott B. McLean, Shirin Djalalinia, Thet Thet Mu, Yves Martin-Prével, Rafael N. Pichardo, Gailute Bernotiene, Pietro Amedeo Modesti, Frederick C. W. Wu, Chandini Nekkantti, Daniela Rodrigues, Tandi E. Matsha, Mihai Gafencu, Xingwang Ye, Salar Rahimikazerooni, Trevor S. Ferguson, Christophe Tzourio, Marie Zins, Fernando Rodríguez-Artalejo, Xu Ma, Elin Pettersen Sørgjerd, Lourdes Ribas-Barba, Nalan Uysal, Salim Berkinbayev, Enisa Kujundzic, Sari Voutilainen, Iraj Mohebbi, Heiner Boeing, Jorge Mota, Jana Námešná, Maria Tsigga, Zivka Dika, Gulmira Aitmurzaeva, Xu Lin, Valéria Regecová, Herman Schargrodsky, Stevo Popovic, Amelia C. Crampin, Hannu Uusitalo, André Luiz Sena Guimarães, Ali Esmaeili, Catherine Kyobutungi, Virginija Dulskiene, Diego Augusto Santos Silva, David De Ridder, Lizzy M. Brewster, Hashem Jaddou, Eunice Ugel, José Camolas, Azli Baharudin, Idris Guessous, Sok King Ong, Tabara Yasuharu, Ali Ghanbari, Anne W. Taylor, Iraj Nabipour, Justyna Godos, Cyrus Cooper, Bruna Gonçalves Cordeiro da Silva, Gonzalo Valdivia, Gyulli M. Kazakbaeva, Takuro Furusawa, Pawel Kurjata, Diego Vanuzzo, Marvin Cervantes-Loaiza, Karen Morgan, Mostafa Qorbani, Rute Santos, Marika Ferrari, Diego Salmerón, Ida Maria Schmidt, Gao Pei, Abu Am Hanif, Balkish M. Naidu, Maria Wany Louzada Strufaldi, Moesijanti Soekatri, Marcia Scazufca, Katharina Maruszczak, Jacqueline Ramke, Elvis Oa Wambiya, Kairit Mikkel, Napoleón Pérez-Farinós, Natalia Nowak-Szczepanska, Miao Li Chee, Jose Sanchez-Abanto, Rajaa Al-Raddadi, Michel Joffres, Vayia Rarra, Ningli Wang, Charmaine A. Duante, Sheikh Mohammed Shariful Islam, Manoli Garcia-de-la-Hera, Weili Yan, Dong Wook Shin, Rômulo Araújo Fernandes, Ilona Nenko, Sanjib Kumar Sharma, Alfonso Siani, Indrapal I. Meshram, Imelda A. Agdeppa, Ei Ei K. Nang, Ian Rouse, Avula Laxmaiah, Ana M. B. Menezes, Yih Chung Tham, Ebrahim Eftekhar, María José Tormo, Felicia Cañete, Marie Eliasen, Lutgart Braeckman, Dirk Vanderschueren, Genc Burazeri, Kari Kuulasmaa, Jesús Vioque, Marisa K. Sophiea, Agneta Sjöberg, Katarzyna Dereń, Albertino Damasceno, Jochanan Stessman, Stig E. Bojesen, Aline Meirhaeghe, Else Karin Grøholt, Flávio Danni Fuchs, Robert Lundqvist, Frédéric Gottrand, Jeongseon Kim, Helmut Schröder, Joanna Baran, Karina Mary de Paiva, Yousef Khader, Eric Monterrubio-Flores, Aneta Weres, Hans Concin, Damaskini Valvi, Sari Hantunen, Machi Suka, Elena Sacchini, Norbert Amougou, Ursula Kiechl-Kohlendorfer, Edwige Landais, Viktoria Anna Kovacs, Rosemarie Martin, Kenneth James, Amaneh Shayanrad, Grethe S. Tell, Norazizah Ibrahim Wong, Vedrana Sember, Anelise Reis Gaya, Konrad Jamrozik, Thorkild I. A. Sørensen, Martin Neovius, Urho M. Kujala, Nathalie Michels, Marcel Goldberg, Alexandra Cucu, Liliana Dacica, Adelheid Weber, Hermann Pohlabeln, Sandjaja, Jukka T. Salonen, Patricia Varona-Pérez, Tiina Laatikainen, Jolanta Słowikowska-Hilczer, Ana Paula Carlos Cândido, Julie Taylor, Anabela Mota-Pinto, Cora L. Craig, Teresa Shamah-Levy, María Dolores Chirlaque, Mohd Azahadi Omar, Dominique Cottel, Charumathi Sabanayagam, Andrea Gazzinelli, Mieczysław Litwin, Sadaf G. Sepanlou, Adolfo Rubinstein, Abbas Dehghan, Rildo de Souza Wanderley Júnior, Wenhua Zhao, Aleksandra Piwońska, Yong Tao, Bontha V. Babu, Marc J. Gunter, Harunobu Nakamura, Wojciech Drygas, Eiji Oda, Jia Li Duan, Stefan Söderberg, Anthony Kafatos, Lynell V Maniego, Els Clays, Wei-Yen Lim, Marshall K. Tulloch-Reid, Mariachiara Di Cesare, Mattias Johansson, Simona Costanzo, Margot González-León, Matthias Nauck, Henry Völzke, George Luiz Lins Machado-Coelho, Annette Peters, Rajiv T Erasmus, Juan Francisco Miquel, Andrea Gualtieri, Abdul Hamid Zargar, Kaare Christensen, Peter Willeit, Tanja Stocks, Christine Cameron, Samuel C. Dumith, Janina Petkeviciene, Boyd Swinburn, Magdalena Muc, Sabine Schipf, Tajana Zeljkovic Vrkic, Martin Bobak, Damian K Francis, Veronica Mocanu, Karien Stronks, Antonisamy Belavendra, Artur Mazur, Nagalla Balakrishna, Jardena J. Puder, Mehrdad Azmin, Shelly R. McFarlane, Sara Santos Sanz, Yang Yang, Anneke Blokstra, Rafel Ramos, Ertugrul Celikcan, Jody C Miller, Jesús Ibarluzea, Svetlana A. Shalnova, Maria Elisa Zapata, Guansheng Ma, Fereidoun Azizi, Beatriz D'Agord Schaan, Pedro Marques-Vidal, William A. Neal, Ana B. Crujeiras, Zhenyu Zhang, Naser Ahmadi, Abdullatif Husseini, Alun Evans, Jiang He, Edyta Łuszczki, Maria G. Stathopoulou, Alibek Mereke, Mari-Liis Tammesoo, Axel C. Carlsson, Helen Gonçalves, Idowu O Senbanjo, Jim Mann, Rajendra Pradeepa, Juel Jarani, Eva Martos, Eugene Sobngwi, Themistoklis Tzotzas, Vassilis Zafiropulos, Reina Engle-Stone, Atul Trivedi, Hui Cai, Sarah Filippi, Georg Posch, Galina Obreja, Cecily Kelleher, Sareh Eghtesad, Chung T Nguyen, Kay-Tee Khaw, Joseph Cacciottolo, Ana Henriques, Yi-Ting Lin, Anil Poudyal, Liam Smeeth, Kenji Shibuya, Emma Ruiz Moreno, Annamari Lundqvist, Thor Aspelund, Caroline H.D. Fall, Philippe Amouyel, Kristyna Zejglicova, Argyro Karakosta, Piotr Bandosz, Juvenal Soares Dias-da-Costa, Maria Lazo-Porras, Maung Maung Than Htike, Dalia Luksiene, Jutta Stieber, Augusto Di Castelnuovo, Aryeh D. Stein, Lechaba Tshepo, Judith Benedics, Aletta E. Schutte, Jürgen König, Magdalena Korzycka, Grzegorz Sobek, Dimitrios Trichopoulos, Tai Hing Lam, Yn-Tz Sung, Masanori Iwasaki, Elias F. Gudmundsson, Antonio Mistretta, Daniel Lemogoum, Nimmathota Arlappa, Isabelle Herter-Aeberli, Khanh Le Nguyen Bao, Shoichiro Tsugane, Kaosar Afsana, Alireza Sadjadi, Myriam Galfo, Jean Claude Mbanya, Bernardo L. Horta, Marleen E. Hendriks, M. Arfan Ikram, Fadia AlBuhairan, Huashuai Chen, Marzieh Katibeh, Sidsel Graff-Iversen, Sahar Saeedi Moghaddam, Larissa Pruner Marques, Louise Eriksen, Aleksandra Gomula, Ricky Eddie, Maciej Banach, Jost B. Jonas, Andrea R. V. R. Horimoto, Slavica Sović, Charles Mondo, Felix Gutzwiller, Mariana Sbaraini, Aye Aye Sein, Henrike Galenkamp, Jaume Marrugat, Nazan Yardim, Cecilia Björkelund, Luigi Palmieri, Roya Kelishadi, Jie Mi, Nahla Hwalla, Jing Liu, Davide Noto, Panayiotis K. Yiallouros, Kelias P. Msyamboza, Judith Simons, Sofia Malyutina, Michele Monroy-Valle, Andres Metspalu, Lariane M Ono, Rafaela Rosário, Flora A. Ukoli, Efthymios Kapantais, Enzo Manzato, S. Goya Wannamethee, Alison J Price, Gregorio Varela-Moreiras, Ali Reza Safarpour, Erfan Ghasemi, Janine Clarke, René Charles Sylva, Wan Nazaimoon Wan Mohamud, Zhamyila Usupova, Chaoqiang Jiang, Julio Zuñiga Cisneros, Freja B Kampmann, Wei Cheng Lo, Reza Mohammadpourhodki, Kaspar Staub, Mojtaba Farjam, Vincenzo Solfrizzi, Garry L. Jennings, Fabio Galvano, Monika Zuziak, Karin De Ridder, Lucie Viet, Anna Bugge, Mehdi Yaseri, Safiah Md Yusof, Sandra C. Fuchs, Emmanuel Cohen, Snehalatha Chamukuttan, Maria Ruiz-Castell, Karen Sparrenberger, Pedro Plans-Rubio, Wei Zheng, Eldridge Ferrer, Martijn Huisman, Maria Hassapidou, Iris Pigeot, Jakub Stokwiszewski, Domenico Palli, Ewelina Czenczek-Lewandowska, Ramiro Guerrero, Farzad Hadaegh, Han Cg Kemper, Saeid Safiri, Ivan Pećin, Arnaud Chiolero, Niels Møller, Jorge Bezerra, Ulrike Gehring, Iná S. Santos, Dénes Molnár, Muhammad Fadhli Mohd Yusoff, Marie Moitry, Nizal Sarrafzadegan, Jacqueline F. Price, Ranko Stevanovic, Sai Yin Ho, Georg Lappas, Alberto Palloni, Malay K. Mridha, Elaine M. Dennison, Jeonghee Lee, Saeid Eslami, Rahman Shiri, Japhet Killewo, Juergen Breckenkamp, Mathilde Kersting, Y Nikitin, Iqbal Bata, Geetha R Menon, Maria Avdicova, Sanjay Rampal, Antônio Augusto Moura da Silva, Kirsten Mehlig, Chien-An Sun, Ramin Heshmat, Violeta Iotova, Stefaan Demarest, Mette Rasmussen, Dirk De Bacquer, San-Lin You, Suzanne N Morin, Martin Gulliford, Maties Torrent, Luc Dauchet, Fred Paccaud, Paibul Suriyawongpaisal, Sherali Rakhmatulloev, Hyeon Chang Kim, Markku Peltonen, Ruth Frikke-Schmidt, Vera Musil, Ahmad Ali Zainuddin, Angela Chetrit, Dan Zhu, Gowri Mahasampath, Ulrich Keil, Sérgio Viana Peixoto, Haiquan Xu, Helle-Mai Loit, Valérie Deschamps, Ilpo Huhtaniemi, Lijuan Liu, Marialaura Bonaccio, Altan Onat, Rody G. Sy, José María Huerta, Ko Ko Zaw, Akihiro Yoshihara, Peter Ueda, Belgin Ünal, Rachel Dankner, Andrzej Wiecek, Eman Aly, Ruzena Kubinova, Justina Vaitkeviciute, Hanna Tolonen, Priscilla Duboz, Orn Olafsson, Yin Guo, Chiara Donfrancesco, Salim Mohanna, Dusan Grafnetter, Daniel Weghuber, Ali Ahmadi, Rosemary B. Duda, E. Shyong Tai, Louise A. Baur, Nihal Thomas, Prabhdeep Kaur, Norlaila Mustafa, Shariq Rashid Masoodi, Liis Nelis, Badreya Al-Lahou, J. Jaime Miranda, Lèlita Santos, Aroor Bhagyalaxmi, Mohamed Bamoshmoosh, Børge G. Nordestgaard, Jeannette Lee, Ahmad Reza Dorosty, Alain Morejon, Ying-Wei Wang, Jakob Tarp, Rosalba Rojas-Martínez, Luxia Zhang, Bahram Mohajer, Maja Bæksgaard Jørgensen, Jurate Klumbiene, Zhengming Chen, Ambady Ramachandran, Andrea Rodriguez-Martinez, Alisha N. Wade, Suyeon Park, Janne Schurmann Tolstrup, Lucjan Szponar, Krishna Kumar Aryal, Tahir Aris, Mahfuzar Rahman, Dorja Vočanec, Juan P. González-Rivas, Rob M. van Dam, Daniel Bia, Oonagh Markey, Ryutaro Ohtsuka, Kumiko Ohara, Ričardas Radišauskas, Jurate Medzioniene, Tiina Vlasoff, Tania Tello, Suzanne C. Ho, Kodavanti Mallikharjuna Rao, May Soe Aung, Vesselka Duleva, Michael Hobbs, Lutgarde Thijs, Marjolein Visser, Parasmani Dasgupta, Inge Huybrechts, Raimund Erbel, Alice Bonilla-Vargas, Hermann Brenner, Mohammad Reza Fattahi, Jolanda Hyska, Roman Topor-Madry, Ranjit Mohan Anjana, Merike Liivak, Eruke E. Egbagbe, Mathilde Savy, Herculina S. Kruger, Neil Murphy, Vinay Nangia, Cesar G. Victora, Mostafa K. Mohamed, H. Bas Bueno-de-Mesquita, Gabriella Gruden, Marcos André Moura-dos-Santos, Mohammed Rasoul Tarawneh, Maria Teresa Menzano, Francesco Branca, Abdonas Tamosiunas, Elena Bogova, Niveen M E Abu-Rmeileh, Maroje Sorić, Aleksander Giwercman, Elżbieta Dziankowska-Zaborszczyk, Tatjana Hejgaard, Yves Kameli, Margarita Samoutian, Andreia N. Pizarro, Jin Soo Moon, Frank Claessens, Zulfiqar A Bhutta, Frank Tanser, Nor Azwany Yaacob, Vanina Bongard, Gregor Jurak, Johan G. Eriksson, Christina-Paulina Lambrinou, Hanspeter Stamm, Kim Overvad, Yanping Li, Carsten Oliver Schmidt, Thomas Meinertz Dantoft, Wichai Aekplakorn, Anwar Batieha, Eduardo Capuano, Teresa Haugsgjerd, Jeremy M. Jacobs, Paola Russo, Nguyen D Nguyen, Luis Revilla, Hossein Poustchi, Farid Najafi, Giovanni de Gaetano, Wan Mohamad Wan Bebakar, Paul Elliott, Denise Eldemire-Shearer, Angela Döring, Giovanni Viegi, Xiaoguang Yang, María-Elena González-Villalpando, Maria Puiu, Maria Benedetta Donati, Andrew Wong, Tomasz Zdrojewski, Carlos P. Boissonnet, Mohamad Hasnan Ahmad, Mahmudur Rahman, Günther Fink, Marcia Makdisse, Dragana P Jovic, Aline Wagner, Coimbatore Subramaniam Shanthirani, Pascal Bovet, Dong Wook Kim, Tom Wilsgaard, Anders Grøntved, Thirunavukkarasu Sathish, Antonia Trichopoulou, Noushin Mohammadifard, Igor Spiroski, Natasja M. van Schoor, Cláudia S. Minderico, Betina H. Thuesen, Queenie Chan, Ulf Ekelund, Laura A. Rodríguez-Villamizar, Line Lund Kårhus, Cihangir Erem, Amina Barkat, Maria Paula Santos, Fernanda Cunha Soares, Constanta Huidumac Petrescu, Allan G. Hill, Honor Bixby, Benoît Salanave, Joana Carvalho, Maigeng Zhou, Ofra Kalter-Leibovici, Roy A Wong-McClure, Kim F. Michaelsen, Doris Stöckl, Rosalynn Siantar, Jouko Saramies, José R. Banegas, Quang Ngoc La, Uruwan Yamborisut, Parinaz Mehdipour, Farhad Pourfarzi, Sudha Ramachandra Rao, Katsuyasu Kouda, Chien-Jen Chen, Rafael dos Santos Henrique, Martin Nankap, Allan Linneberg, Ronald D. Gregor, Rudolf Kaaks, Maria do Carmo Franco, Marta García-Solano, Beata Gurzkowska, Bahman Cheraghian, Stefaan De Henauw, Daniel Ferrante, Johanna A. Otero, Jamila Abubakar Garba, Antonio Pedro Graça, Sumit Bharadwaj, Shiqi Zhen, Xiu-Hua Guo, Prashant Mathur, Raphael Mendes Ritti-Dias, Kouamelan Doua, Esteban Carmuega, Majid Shirani, Przemyslaw Slusarczyk, Petra Rust, Visnja Djordjic, Farahnaz Joukar, Johanna Gunnlaugsdottir, Leila Houti, Nayu Ikeda, Imperia Brajkovich, Amirabbas Momenan, Erik J. Timmermans, Marcin Rutkowski, Biruta Velika, Joana Araújo, Jostein Steene-Johannessen, Christa L. Lilly, Per Tynelius, Michael Tornaritis, Anne Juolevi, Fatima Zahra Laamiri, Carl Lachat, Kai-Uwe Saum, Espen Bjertness, Ana P. Ortiz, Joel G. R. Roy, Himanshu K. Chaturvedi, Michelle Holdsworth, Niels Wedderkopp, Johan Van der Heyden, Mukharram M. Bikbov, Hsien-Ho Lin, Eva Corpeleijn, Harshpal Singh Sachdev, Mohammad Reza Mirjalili, Maria del Cristo Rodriguez-Perez, Michala Lustigová, Tuyen D Le, Teresa Norat, Hana Zamrazilová, Garry Brian, Tien Yin Wong, Rosa Haghshenas, Clive Osmond, Diego Giulliano Destro Christofaro, Mahmood Moosazadeh, Vilma Irazola, Olli T. Raitakari, Marco Aurélio Peres, Terho Lehtimäki, Shuohua Chen, Dimitrios Papandreou, Robert J. Adams, Sigmund A. Anderssen, Peter T. Katzmarzyk, Luisa M Macieira, Félicité Tchibindat, Lital Keinan Boker, Toshiharu Ninomiya, Morten Sodemann, Jytte Halkjær, Zbigniew Kułaga, Sophie Visvikis-Siest, Farshad Farzadfar, N Capkova, Zumin Shi, Maria Turley, Zbigniew Gaciong, Giovanni Veronesi, Martin McKee, Veikko Salomaa, Gilad Twig, Elisabetta L. Romeo, Peter Kristensen, Grazyna Jasienska, Victor Guillermo Sequera, Mario V. Capanzana, Con Burns, Emanuela Pettenuzzo, Ming-Dong Wang, Jonathan Giovannelli, Stela McLachlan, Ellis Owusu-Dabo, Stefania Toselli, Maria Teresa Anselmo Olinto, Senthil K Vasan, Sara Schramm, Xenophon Theodoridis, Moyses Szklo, Ramfis Nieto-Martínez, Viswanathan Mohan, Guillermo Frontera, Rahul Malhotra, Thomas Ferrao, Dongfeng Gu, Tomas Vega, Hynek Pikhart, Päivi Mäki, Heba Fouad, Vilnis Dzerve, Christina Howitt, Seyed Mohammad Hashemi-Shahri, Jenny M. Kindblom, Marjolijn C. E. Bragt, G. K. Mini, Qian Wang, Liufu Cui, Andrzej Galbarczyk, Sylvain Sebert, Vilmundur Gudnason, Loreto Santa Marina, Kairat Davletov, Afshin Ostovar, Niloofar Peykari, Nicholas J. Wareham, Wilma M. Hopman, Karl-Heinz Jöckel, Jussi Kauhanen, Breige A. McNulty, Alina Kerimkulova, Youcef Laid, Claes Ohlsson, Stefan Kiechl, Alicia Matijasevich, Boban Mugoša, Srinivasan Kannan, Jyrki K. Virtanen, Mohan Deepa, Mangesh S. Pednekar, Shahla AlDhukair, Cynthia M. Pérez, Vera Lanska, Tint Swe Latt, Dominique Hange, João Luiz Bastos, Eliza Markidou Ioannidou, Leticia Hernandez Cadena, Maya Tanrygulyyeva, Reza Malekzadeh, Dimitrios Poulimeneas, Pedro Ordunez, Thomas Waldhör, Ioannis Pagkalos, Carlo M. Barbagallo, Abla M. Sibai, Peter Vollenweider, Asher Fawwad, Emily Sonestedt, Elena Pahomova, Santosh K. Bhargava, Patrick Kolsteren, Aya Mostafa, Fangfang Chen, Flavio Nervi, Imre Janszky, Arvind Pandey, Renata Cifkova, Alexandre C. Pereira, Alejandro Diaz, Alireza Ansari-Moghaddam, Rachakulla Hari Kumar, Jaakko Mursu, Luis A. Moreno, Glen Gironella, Jelena Kos, Tilema Cama, Haakon E. Meyer, Jun Ma, Raphael E. Arku, Ziad Abdeen, Rusidah Selamat, Dianna J. Magliano, Jitendra Jonnagaddala, Konstantinos Gkiouras, Paul Korrovits, Paola Nardone, Paolo Vineis, Kotsedi D Monyeki, Khuong Quynh Long, Alberto Barceló, Camilla T. Damsgaard, Constance Schultsz, Frank J Rühli, Santiago F. Gomez, Tara Coppinger, Muhammad Islam, Pierre Traissac, Eleonora d'Orsi, Irfan Nuhoglu, Rui Providência, Bernard Maire, Leandra Abarca-Gómez, Sinead Brophy, Daniela Pierannunzio, Cristina Taddei, Wen-Harn Pan, Gregor Starc, Abdullah Alkandari, Saeed Dastgiri, Lien Braeckevelt, Gustavo Velasquez-Melendez, Sudhir Kowlessur, Bagher Larijani, Cynthia Robitaille, Mohamed M. Ali, Steiner Krokstad, Noor Ani Ahmad, Anar Dushpanova, Agustinus Soemantri, Susana Sans, Ionela Pascanu, Gwenaëlle Le Coroller, Inger Ariansen, Abhijit Sen, Sergej M. Ostojic, Silvana Donoso, Felix K. Assah, Juan A Rivera, Peter H. Whincup, Oana-Florentina Gheorghe-Fronea, Hanan F. Abdul Rahim, Yadlapalli S. Kusuma, Michael Knoflach, Moein Yoosefi, Cassiano Ricardo Rech, Paul Ferdinand M. Reganit, Tomi-Pekka Tuomainen, Francesco Gianfagna, Stefania Maggi, Mohammad Hossein Somi, Behrooz Hamzeh, Bethlehem D. Solomon, Herman Borghs, Zhanna Kalmatayeva, Heidi Klakk, Akram Pourshams, Naomi S. Levitt, Miquel Porta, Vesna Jureša, Alexander D. Deev, Son Thai Pham, Paula Margozzini, Silvia Bel-Serrat, Dora Romaguera, Monira Alarouj, Winsome R. Parnell, Marloes Cardol, David Faeh, Antonio Bernabe-Ortiz, Giota Touloumi, Maryam Kavousi, Sanja Musić Milanović, Jalila El Ati, Sauli Herrala, Liang Xu, Sirkka Keinänen-Kiukaanniemi, Ian Hambleton, Stefan Savin, Andre Pascal Kengne, R. Krishna Kumar, Kurt Widhalm, Marco M Ferrario, Parisa Amiri, Yi Song, Jianfeng Wu, Jeannette Klimont, Jean Ferrières, Farhad Zamani, Shina Avi, Luis Paulo Gomes Mascarenhas, Aluísio J D Barros, Reecha Sofat, Koen Van Herck, Hoang Van Minh, Enrique Gutiérrez-González, Martine Vrijheid, Susana Cararo Confortin, Antonis Zampelas, Bogdan Wojtyniak, Ausra Petrauskiene, Juha Auvinen, Maryam Sharafkhah, Emanuel Zitt, Majid Ezzati, Young-Ho Khang, Ellina Rakhimova, Magdalena Klimek, Luís Lopes, Erkin M. Mirrakhimov, Maria Lc Iurilli, Günay Can, Mark Woodward, Esther Lopez-Garcia, Mauro Virgílio Gomes de Barros, Ahmed A. Madar, Rainford J. Wilks, Shoaib Afzal, Melanie J. Cowan, Gareth Stratton, Eduardo Salazar Martinez, Sameer Narake, Norie Sawada, Li Juan Wu, Adrian Richter, Licia Iacoviello, Hanno Ulmer, Deepak Amarapurkar, Mohsen Ibrahim, Hamed Pouraram, Massimo Salvetti, Hung-Kwan So, Yonghua Hu, Lars Ängquist, Thi Tuyet-Hanh Tran, Charles Lunogelo, Sabina Zambon, Angelika Schaffrath Rosario, Lauren Lissner, Kamarul Imran Musa, Deepa Weerasekera, Bihungum Bista, Takafumi Ishida, Ekaterina Chikova-Iscener, Mirjam M. Heinen, Tazeen H. Jafar, Semánová Csilla, Raija Korpelainen, Edward W. Gregg, Laura Gutierrez, Victor M. Herrera, Aristides M. Machado-Rodrigues, Fatemeh Malekzadeh, Shouling Wu, Jennifer L. Baker, Clicerio González-Villalpando, Irene G. M. van Valkengoed, Anna Fijałkowska, Meghnath Dhimal, Murat Topbaş, George Moschonis, Robert Eggertsen, Quang Ngoc Nguyen, Janette Walton, Elnaz Faramarzi, Nasheeta Peer, Radka Taxová Braunerová, Harald Geiger, Morteza Shamshirgaran, Lela Shengelia, María Ángeles Dal Re Saavedra, Khem Bahadur Karki, Timothy J. Key, Maria G. Grammatikopoulou, Susana Vale, Bernhard O. Boehm, Songhomitra Panda-Jonas, Iveta Pudule, Elisabete Ramos, Lacramioara Aurelia Brinduse, Paul H. Lee, Terence W O'Neill, Javad Aghazadeh-Attari, Margus Punab, Bojan Jelaković, Eliza Cinteza, Ha Tp Do, and Alison J. Hayes
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education.field_of_study ,business.industry ,Population ,Distribution (economics) ,medicine.disease ,Obesity ,Geography ,medicine ,Underweight ,medicine.symptom ,education ,business ,Body mass index ,Demography - Published
- 2020
48. Cardiovascular risk in patients with severe mental illness in Italy
- Author
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Claudio Mencacci, Virginio Salvi, C. Donfrancesco, Luigi Palmieri, Andrea Aguglia, Francesco Barone-Adesi, Mario Amore, Gianluca Serafini, Davide Bianchi, and Filippo Dragogna
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Adult ,Male ,cardiovascular risk ,medicine.medical_specialty ,Bipolar Disorder ,Health Status ,Population ,Life Expectancy ,Risk Factors ,Diabetes mellitus ,Internal medicine ,Acute care ,severe mental illness ,Medicine ,Humans ,Bipolar disorder ,Cardiovascular risk ,Schizophrenia ,Severe mental illness ,education ,Aged ,Metabolic Syndrome ,education.field_of_study ,Framingham Risk Score ,business.industry ,Mental Disorders ,Middle Aged ,medicine.disease ,schizophrenia ,Psychiatry and Mental health ,Blood pressure ,Italy ,Cardiovascular Diseases ,Heart Disease Risk Factors ,Hypertension ,Female ,Metabolic syndrome ,business ,Research Article - Abstract
Background Patients with severe mental illness (SMI), such as schizophrenia or bipolar disorders, are more frequently affected by metabolic syndrome and cardiovascular (CV) diseases than the general population, with a significant reduction in life expectancy. Beyond metabolic syndrome, quantifying the risk of CV morbidity in the long-term may help clinicians to put in place preventive strategies. In this study, we assessed 10-year CV risk in patients with SMI and healthy individuals using an algorithm validated on the Italian general population. Methods Patients aged 35–69 years diagnosed with SMI were consecutively recruited from psychiatric acute care units. Single CV risk factors were assessed, and 10-year CV risk calculated by means of the CUORE Project 10-year CV risk algorithm, based on the combination of the following risk factors: age, systolic blood pressure, total and high-density lipoprotein cholesterol, diabetes, smoking habit, and hypertensive treatment. Patients’ data were compared with those from the general population. The 10-year CV risk was log-transformed, and multivariable linear regression was used to estimate mean ratios, adjusting for age, and education. Results Three hundred patients and 3,052 controls were included in the analysis. Among men, the 10-year CV risk score was very similar between patients with SMI and the general population (mean ratio [MR]: 1.02; 95%CI 0.77–1.37), whereas a 39% increase in 10-year CV risk was observed in women with SMI compared to the general population (MR: 1.39; 95%CI 1.16–1.66). Conclusions In our study, women with SMI were consistently more at risk than the general population counterpart, even at younger age.
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- 2020
49. Sex Hormone-Binding Globulin and Its Association to Cardiovascular Risk Factors in an Italian Adult Population Cohort
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Brigitta Buttari, Rachele Riganò, Luigi Palmieri, Cinzia Lo Noce, Stefan Blankenberg, Tanja Zeller, Serena Vannucchi, Anna Di Lonardo, Marco Gabbianelli, and Chiara Donfrancesco
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polycyclic compounds ,sex hormone-binding globulin ,cardiovascular risk biomarker ,epidemiology ,age ,sex ,Electrical and Electronic Engineering ,reproductive and urinary physiology ,hormones, hormone substitutes, and hormone antagonists ,Atomic and Molecular Physics, and Optics - Abstract
Abnormal sex hormone-binding globulin (SHBG) and sex hormone concentrations are the cause or the consequence of cardiometabolic diseases, however, the clinical correlates of SHBG is clearly less understood. In our study we investigate sex- and age-specific serum SHBG levels and their association with cardiovascular risk (CVR) factors and high-risk conditions in an adult cohort of Italian population. Data from 1176 men and 2236 women, aged 20–81 were analyzed and serum SHBG determined in stored samples using an immunoassay. SHBG concentrations, higher in women than in men in the younger age groups, exhibited a curvilinear increase with age in men and a U-shaped curve across the lifespan in women, with a decrease from the 2nd to the 6th decade of age and an increase after the 6th decade when SHBG concentrations were similar in both sexes. Low SHBG serum levels correlated with the traditional CVR factors diabetes, obesity, and hypertension, whereas high level of SHBG correlated with cholesterol HDL. These associations were more numerous in women than in men, in whom decreased with age. The sex- and age specific differences observed in our population-based cohort should be considered in establishing reference ranges and clinical cut-off points to improve CVR score charts and therapeutic approaches.
- Published
- 2022
50. Drosophila melanogaster Uncoupling Protein-4A (UCP4A) Catalyzes a Unidirectional Transport of Aspartate
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Paola Lunetti, Ruggiero Gorgoglione, Rosita Curcio, Federica Marra, Antonella Pignataro, Angelo Vozza, Christopher L. Riley, Loredana Capobianco, Luigi Palmieri, Vincenza Dolce, Giuseppe Fiermonte, Lunetti, Paola, Gorgoglione, Ruggiero, Curcio, Rosita, Marra, Federica, Pignataro, Antonella, Vozza, Angelo, Riley, Christopher L., Capobianco, Loredana, Palmieri, Luigi, Dolce, Vincenza, and Fiermonte, Giuseppe
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QH301-705.5 ,ß-alanine ,Organic Chemistry ,uncoupling proteins ,uncoupling proteins, DmUCP4A, mitochondrial transporters, aspartate transport, alanine, biogenic amines metabolism, Parkinson’s disease, CG6492, mitochondrial carrier family, N-acetylaspartate ,DmUCP4A ,mitochondrial transporters ,aspartate transport ,biogenic amines metabolism ,Parkinson’s disease ,CG6492 ,mitochondrial carrier family ,N-acetylaspartate ,General Medicine ,Catalysis ,Computer Science Applications ,Inorganic Chemistry ,Chemistry ,Biology (General) ,Physical and Theoretical Chemistry ,QD1-999 ,Molecular Biology ,Spectroscopy - Abstract
Uncoupling proteins (UCPs) form a distinct subfamily of the mitochondrial carrier family (MCF) SLC25. Four UCPs, DmUCP4A-C and DmUCP5, have been identified in Drosophila melanogaster on the basis of their sequence homology with mammalian UCP4 and UCP5. In a Parkinson’s disease model, DmUCP4A showed a protective role against mitochondrial dysfunction, by increasing mitochondrial membrane potential and ATP synthesis. To date, DmUCP4A is still an orphan of a biochemical function, although its possible involvement in mitochondrial uncoupling has been ruled out. Here, we show that DmUCP4A expressed in bacteria and reconstituted in phospholipid vesicles catalyzes a unidirectional transport of aspartate, which is saturable and inhibited by mercurials and other mitochondrial carrier inhibitors to various degrees. Swelling experiments carried out in yeast mitochondria have demonstrated that the unidirectional transport of aspartate catalyzed by DmUCP4 is not proton-coupled. The biochemical function of DmUCP4A has been further confirmed in a yeast cell model, in which growth has required an efflux of aspartate from mitochondria. Notably, DmUCP4A is the first UCP4 homolog from any species to be biochemically characterized. In Drosophila melanogaster, DmUCP4A could be involved in the transport of aspartate from mitochondria to the cytosol, in which it could be used for protein and nucleotide synthesis, as well as in the biosynthesis of ß-alanine and N-acetylaspartate, which play key roles in signal transmission in the central nervous system.
- Published
- 2022
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